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1. Defected fuel rods identification in TRIGA Reactors: The experience at the ENEA Casaccia TRIGA RC-1 reactor

Author

Lepore L., Falconi L., Fabrizio V., Roberti A., Formenton D., Iorio M.G., and Sperandio L.

Subjects
fuel defects, fission gases leakage, gamma spectrometry characterization, Physics, QC1-999
Abstract

Experience in running TRIGA reactors all around the world has shown that fuel cladding failures can occur. Fission products, especially in gaseous physical form, can exit the defected fuel rods being dispersed within the water primary coolant. Suspects of a cladding failure event can be confirmed by detection of short-lived fission products, i.e., Krypton, Xenon, and even Iodine isotopes in primary water, or within the ionic-exchange resins tank installed for the purification of the primary coolant loop. The magnitude of the release of those ‘key-indicators’ from the defected fuel element(s) is the driving method by which the defected rod(s) can be identified. ‘Significant’ releases can be detected with a direct online sampling of the water from the top of the suspected fuel rod with reactor at power, leading this water to an online high-resolution gamma spectrometry analysis system. By considering delays due to the water velocity in tubes and decay time of radionuclides identified within the gamma spectrum, it is possible to calculate the concentration of those radionuclides just emerging from the inspected fuel rod. Releases lower than the minimum detection capabilities of the previous online experimental configuration push to modify the detection method with an indirect identification of the release. This is the case when the ‘normal’ radioactive background of the activated water, when reactor is on power, is the dominant component in the gamma spectrum of the sampled water, and fission gases (even produced) are not identified promptly, i.e. a relationship to a specific fuel rod by the sampling circuit before could not be identified. The paper describes the experience carried out at the Italian ENEA TRIGA RC-1 reactor, deepening the technical aspects and solutions applied to solve the issue. In particular, a ‘significant’ release has been found in the instrumented fuel rod within ring B, i.e. the inner fuel ring, exposed to the maximum neutron flux of the reactor. The leaking element was found within a week, in two days of operation, being the sampling system designed on detection of minutes-shortlived fission gases (no need to ‘cool’ down the primary loop by waiting decay of hours-lived radionuclides). After the removal of the instrumented fuel rod in ring B, further days in searching other ‘significant’ release with the sampling circuit before have reported nothing detected. But in samples of water taken after reactor shutdown, some iodine emerged after decaying of ‘normal’ radioactive background of the activated water. This was sufficient evidence of another defected fuel rod in the pool. Identification of the latter defected fuel element is still ongoing, being based on: 1) selective removal of rod(s) from the reactor core, 2) run power of the reactor, 3) take samples of water after shutdown and measure iodine after decaying of ‘normal’ radioactive-background of the activated water, 4) identify the rod responsible of the remaining leakage when no further iodine is detected.

Published
2023
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6. Test of low-dropout voltage regulators with neutrons and protons

Author

Abovyan, S., primary, Bianchi, B., additional, Cesaroni, M., additional, Corradi, M., additional, Danielyan, V., additional, Falconi, L., additional, Ferraro, R., additional, Fras, M., additional, Gkountoumis, P., additional, Kortner, O., additional, Kroha, H., additional, Longarini, I., additional, Lunadei, R., additional, Ratto, A., additional, Ricci, P., additional, Richter, R., additional, Rosati, S., additional, Santagata, A., additional, and Vari, R., additional

Published
2022
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8. Neutrons propagation in Lead: A feasibility study for experiments in the RSV TAPIRO fast research reactor

Author

Fabrizio, V., Burgio, N., Castelluccio, D. M., Falconi, L., Grasso, G., Lodi, F., Mengoni, A., Peluso, V., Pergreffi, R., Santagata, A., and Sarotto, M.

Subjects
General Medicine
Abstract

The increasing worldwide interest in Lead-cooled Fast Reactors (LFRs) substantiates the need to validate the analytical codes and methods used to support their design. For neutronic analyses, this is chiefly reflected in assessing the impact of nuclear data uncertainties on the integral and local parameters resulting from such analyses. The aim of refining nuclear data moves continuous efforts for more accurate measurements, be them differential or integral, for which adequate facilities are required. The availability at the ENEA's Casaccia research center of a fast source reactor – RSV TAPIRO – provides a unique opportunity to perform new integral experiments in support of fast reactors, including LFRs, owing to the well-characterized neutron spectrum of the thermal column. A series of experiments has been envisaged, dealing with the use of Lead in a reactor. The experiments concern the propagation of neutrons through blocks of materials representing relevant elements of a reactor core, and ranging from pure Lead to mixtures reproducing portions of the reflector and shield in LFRs. The paper is focused on the feasibility study of some of these experiments in which Lead and mixture blocks are inserted in the so-called thermal column of the RSV TAPIRO reactor and irradiated by the neutron flux emerging from the Copper reflector surrounding the reactor core.

Published
2023
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10. HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with different HCV-RNA levels

Author

Di Maio, V. C., Cento, V., Di Paolo, D., Aragri, M., De Leonardis, F., Tontodonati, M., Micheli, V., Bellocchi, M. C., Antonucci, F. P., Bertoli, A., Lenci, I., Milana, M., Gianserra, L., Melis, M., Di Biagio, A., Sarrecchia, C., Sarmati, L., Landonio, S., Francioso, S., Lambiase, L., Nicolini, L. A., Marenco, S., Nosotti, L., Giannelli, V., Siciliano, M., Romagnoli, D., Pellicelli, A., Vecchiet, J., Magni, C. F., Babudieri, S., Mura, M. S., Taliani, G., Mastroianni, C., Vespasiani-Gentilucci, U., Romano, M., Morisco, F., Gasbarrini, A., Vullo, V., Bruno, S., Baiguera, C., Pasquazzi, C., Tisone, G., Picciotto, A., Andreoni, M., Parruti, G., Rizzardini, G., Angelico, M., Perno, C. F., Ceccherini-Silberstein, F., Mariani, R., Paoloni, M., Iapadre, N., Grimaldi, A., Menzaghi, B., Quirino, T., Vecchiet, J., Bruzzone, B., De Maria, A., Di Biagio, A., Marenco, S., Nicolini, L. A., Picciotto, A., Viscoli, C., Casinelli, K., Monache, M. Delle, Lichtner, M., Mastroianni, C., Aghemo, A., Bruno, S., Cerrone, M., Colombo, M., Monforte, A. DʼArminio, Danieli, E., Donato, F., Gubertini, G., Landonio, S., Magni, C. F., Mancon, A., Micheli, V., Monico, S., Niero, F., Puoti, M., Rizzardini, G., Russo, M. L., Alfieri, R., Gnocchi, M., Orro, A., Milanesi, L., Baldelli, E., Bertolotti, M., Borghi, V., Mussini, C., Romagnoli, D., Brancaccio, G., Caporaso, N., Gaeta, G. B., Lembo, V., Morisco, F., Calvaruso, V., Craxì, A., Di Marco, V., Mazzola, A., Petta, S., DʼAmico, E., Cacciatore, P., Consorte, A., Palitti, V. Pace, Parruti, G., Pieri, A., Polilli, E., Tontodonati, M., Andreoni, M., Angelico, M., Antenucci, F., Antonucci, F. P., Aragri, M., Armenia, D., Baiocchi, L., Bellocchi, M., Bertoli, A., Biliotti, E., Biolato, M., Carioti, L., Ceccherini-Silberstein, F., Cento, V., Cerasari, G., Cerva, C., Ciotti, M., DʼAmbrosio, C., DʼEttorre, G., De Leonardis, F., De Sanctis, A., Di Maio, V. C., Di Paolo, D., Francioso, S., Furlan, C., Gallo, P., Gasbarrini, A., Giannelli, V., Gianserra, L., Grieco, A., Grieco, S., Lambiase, L., Lattanzi, B., Lenci, I., Malagnino, V., Manuelli, M., Merli, M., Miglioresi, L., Milana, M., Nosotti, L., Palazzo, D., Pasquazzi, C., Pellicelli, A., Perno, C. F., Romano, M., Santopaolo, F., Santoro, M. M., Sarmati, L., Sarrecchia, C., Sforza, D., Siciliano, M., Sorbo, M. C., Spaziante, M., Svicher, V., Taliani, G., Teti, E., Tisone, G., Vespasiani-Gentilucci, U., Vullo, V., Mangia, A., Babudieri, S., Maida, I., Melis, M., Mura, M. S., Falconi, L., Di Giammartino, D., and Tarquini, P.

Published
2016
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11. Characterization of TRIGA RC-1 neutron irradiation facilities for radiation damage testing

Author

Chiesa, D, Carta, M, Fabrizio, V, Falconi, L, Grossi, A, Nastasi, M, Palomba, M, Pozzi, S, Previtali, E, Rancoita, P, Ranghetti, B, Tacconi, M, Chiesa, Davide, Carta, Mario, Fabrizio, Valentina, Falconi, Luca, Grossi, Angelo, Nastasi, Massimiliano, Palomba, Mario, Pozzi, Stefano, Previtali, Ezio, Rancoita, Pier Giorgio, Ranghetti, Barbara, Tacconi, Mauro, Chiesa, D, Carta, M, Fabrizio, V, Falconi, L, Grossi, A, Nastasi, M, Palomba, M, Pozzi, S, Previtali, E, Rancoita, P, Ranghetti, B, Tacconi, M, Chiesa, Davide, Carta, Mario, Fabrizio, Valentina, Falconi, Luca, Grossi, Angelo, Nastasi, Massimiliano, Palomba, Mario, Pozzi, Stefano, Previtali, Ezio, Rancoita, Pier Giorgio, Ranghetti, Barbara, and Tacconi, Mauro

Abstract

This paper presents the results of neutron flux measurements at two irradiation facilities of the TRIGA Mark II reactor at ENEA Casaccia Research Center, Italy. The goal of these measurements is to provide a complete characterization of neutron irradiation facilities for accurate and precise dose evaluation in radiation damage tests and, more generally, for all applications that need a good knowledge of neutron flux in terms of intensity, energy spectrum and spatial distribution. The neutron activation technique is used to measure the activation rates of several reactions, chosen so to cover the whole energy range of neutron flux spectrum. A multi-group neutron flux measurement is obtained through an unfolding algorithm based on a Bayesian statistical model. The obtained results prove that this experimental method allows to measure the total neutron flux within 2% statistical uncertainty, and to get at the same time a good description of its energy spectrum and spatial distribution.

Published
2020

12. Research priorities for natural ecosystems in a changing global climate

Author

Williams, SE, Hobday, AJ, Falconi, L, Hero, J-M, Holbrook, NJ, Capon, S, Bond, NR, Ling, SD, Hughes, L, Williams, SE, Hobday, AJ, Falconi, L, Hero, J-M, Holbrook, NJ, Capon, S, Bond, NR, Ling, SD, and Hughes, L

Abstract

Climate change poses significant emerging risks to biodiversity, ecosystem function and associated socioecological systems. Adaptation responses must be initiated in parallel with mitigation efforts, but resources are limited. As climate risks are not distributed equally across taxa, ecosystems and processes, strategic prioritization of research that addresses stakeholder-relevant knowledge gaps will accelerate effective uptake into adaptation policy and management action. After a decade of climate change adaptation research within the Australian National Climate Change Adaptation Research Facility, we synthesize the National Adaptation Research Plans for marine, terrestrial and freshwater ecosystems. We identify the key, globally relevant priorities for ongoing research relevant to informing adaptation policy and environmental management aimed at maximizing the resilience of natural ecosystems to climate change. Informed by both global literature and an extensive stakeholder consultation across all ecosystems, sectors and regions in Australia, involving thousands of participants, we suggest 18 priority research topics based on their significance, urgency, technical and economic feasibility, existing knowledge gaps and potential for cobenefits across multiple sectors. These research priorities provide a unified guide for policymakers, funding organizations and researchers to strategically direct resources, maximize stakeholder uptake of resulting knowledge and minimize the impacts of climate change on natural ecosystems. Given the pace of climate change, it is imperative that we inform and accelerate adaptation progress in all regions around the world.

Published
2020

13. A database of the coseismic effects following the 30 October 2016 Norcia earthquake in Central Italy

Author

Villani, Fabio, Civico, Riccardo, Pucci, Stefano, Pizzimenti, Luca, Nappi, Rosa, De Martini, Paolo Marco, Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A.M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C.A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F.R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falconi, L., Falcucci, E., Farabollini, P., Faure Walker, J.P., Ferrarini, F., Ferrario, M.F., Ferry, M., Feuillet, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L.C., Guerrieri, L., Hailemikael, S., Hollingsworth, J., Iezzi, F., Invernizzi, C., Jablonská, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Lo Sardo, L., Malet, J.P., Mariucci, M.T., Materazzi, M., Maubant, L., Mazzarini, F., McCaffrey, K.J.W., Michetti, A.M., Mildon, Z.K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Pérouse, E., Pezzo, G., Piccardi, L., Pierantoni, P.P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pousse, L., Pozzi, A., Proposito, M., Puglisi, C., Puliti, I., Ricci, T., Ripamonti, L., Rizza, M., Roberts, G.P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Soquet, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L.N.J., Wilkinson, M., Zambrano, M., Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Roma (INGV), Istituto Nazionale di Geofisica e Vulcanologia, Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Palermo (INGV), Istituto sull’Inquinamento Atmosferico (CNR-IIA), Consiglio Nazionale delle Ricerche (CNR), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Laboratoire Image, Ville, Environnement (LIVE), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Littoral, Environnement, Télédétection, Géomatique (LETG - Caen), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-Université de Nantes (UN)-École pratique des hautes études (EPHE)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze Fisiche, Informatiche e Matematiche [Modena], Università degli Studi di Modena e Reggio Emilia (UNIMORE), Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut de physique du globe de Strasbourg (IPGS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Geofisica e Vulcanologia – Sezione di Pisa (INGV), Laboratoire de géologie de l'ENS (LGE), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Institut des Sciences de la Terre (ISTerre), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-PRES Université de Grenoble-Institut de recherche pour le développement [IRD] : UR219-Institut national des sciences de l'Univers (INSU - CNRS)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université Joseph Fourier - Grenoble 1 (UJF), Italian National agency for new technologies, Energy and sustainable economic development [Frascati] (ENEA), Departimento di Scienze della Terra [Camerino], Università di Camerino (UNICAM), Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Dynamique globale et déformation active (IPGS) (IPGS-DGDA), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Laboratoire de géologie de l'ENS (LGENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Università degli Studi di Camerino = University of Camerino (UNICAM), Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Università degli Studi di Camerino (UNICAM), Puglisi, C., Proposito, M., Hailemikael, S., Falconi, L., Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-École pratique des hautes études (EPHE)-Université de Nantes (UN)-Université d'Angers (UA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 2 (UR2), Normandie Université (NU)-Normandie Université (NU), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Villani, F., Civico, R., Pucci, S., Pizzimenti, L., Nappi, R., De Martini, P. M., Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A. M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C. A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F. R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falcucci, E., Farabollini, P., Faure Walker, J. P., Ferrarini, F., Ferrario, M. F., Ferry, M., Feuillet, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L. C., Guerrieri, L., Hollingsworth, J., Iezzi, F., Invernizzi, C., Jablonska, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Sardo, L., Malet, J. P., Mariucci, M. T., Materazzi, M., Maubant, L., Mazzarini, F., Mccaffrey, K. J. W., Michetti, A. M., Mildon, Z. K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Perouse, E., Pezzo, G., Piccardi, L., Pierantoni, P. P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pousse, L., Pozzi, A., Puliti, I., Ricci, T., Ripamonti, L., Rizza, M., Roberts, G. P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Soquet, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van Der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L. N. J., Wilkinson, M., and Zambrano, M.

Subjects
Statistics and Probability, data collection, 010504 meteorology & atmospheric sciences, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], Library and Information Sciences, 010502 geochemistry & geophysics, computer.software_genre, 01 natural sciences, Education, 30 October 2016 Norcia earthquake, Earthquakes, ground deformation process, 0105 earth and related environmental sciences, [SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics, surface faulting hazard, Central Apennines, Database, Landslide, data acquisition system, Extensional definition, Computer Science Applications, 13. Climate action, Homogeneous, Georeference, ground deformation process, data acquisition system, Central Apennines, 30 October 2016 Norcia earthquake, Statistics, Probability and Uncertainty, computer, Relevant information, Geology, Information Systems
Abstract

We provide a database of the coseismic geological surface effects following the Mw 6.5 Norcia earthquake that hit central Italy on 30 October 2016. This was one of the strongest seismic events to occur in Europe in the past thirty years, causing complex surface ruptures over an area of >400 km2. The database originated from the collaboration of several European teams (Open EMERGEO Working Group; about 130 researchers) coordinated by the Istituto Nazionale di Geofisica e Vulcanologia. The observations were collected by performing detailed field surveys in the epicentral region in order to describe the geometry and kinematics of surface faulting, and subsequently of landslides and other secondary coseismic effects. The resulting database consists of homogeneous georeferenced records identifying 7323 observation points, each of which contains 18 numeric and string fields of relevant information. This database will impact future earthquake studies focused on modelling of the seismic processes in active extensional settings, updating probabilistic estimates of slip distribution, and assessing the hazard of surface faulting.

Published
2018
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14. Surface ruptures following the 30 October 2016 M w 6.5 Norcia earthquake, central Italy

Author

Civico, R., Pucci, S., Villani, F., Pizzimenti, L., De Martini, P. M., Nappi, R., Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A. M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C. A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F. R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falconi, L., Falcucci, E., Farabollini, P., Faure Walker, J. P., Ferrarini, F., Ferrario, M. F., Ferry, M., Feuillet, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L. C., Guerrieri, L., Hailemikael, S., Iezzi, F., Invernizzi, C., Jablonská, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Lo Sardo, L., Malet, J. P., Mariucci, M. T., Materazzi, M., Mazzarini, F., Mccaffrey, K. J. W., Michetti, A. M., Mildon, Z. K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Pérouse, E., Pezzo, G., Piccardi, L., Pierantoni, P. P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pozzi, A., Proposito, M., Puglisi, C., Puliti, I., Ricci, T., Ripamonti, Licia, Rizza, M., Roberts, G. P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L. N. J., Wilkinson, M., Zambrano, M., Istituto Nazionale di Geofisica e Vulcanologia [Bologna] ( INGV ), Géosciences Montpellier, Institut national des sciences de l'Univers ( INSU - CNRS ) -Université de Montpellier ( UM ) -Université des Antilles ( UA ) -Centre National de la Recherche Scientifique ( CNRS ), Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Bologna (INGV), Istituto Nazionale di Geofisica e Vulcanologia, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Hailemikael, S., Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut de physique du globe de Strasbourg (IPGS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut Terre Environnement Strasbourg (ITES), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A. M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C. A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F. R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falconi, L., Falcucci, E., Farabollini, P., Faure Walker, J. P., Ferrarini, F., Ferrario, M. F., Ferry, M., Feuillet1, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L. C., Guerrieri, L., Iezzi, F., Invernizzi, C., Jablonská, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Lo Sard8, L., Malet, J. P., Mariucci, M. T., Materazzi5, M., Mazzarini, F., Mccaffrey, K. J. W., Michett, A. M., Mildon, Z. K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Pérouse, E., Pezzo, G., Piccardi, L., Pierantoni, P. P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pozzi, A., Proposito, M., Puglisi, C., Puliti, I., Ricci, T., Ripamonti, L., Rizza, M., Roberts, G. P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L. N. J., Wilkinson, M., Zambrano, M., Institut de Physique du Globe de Paris (IPGP), and Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Surface (mathematics), Surface rupture, 010504 meteorology & atmospheric sciences, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], Field data, Geography, Planning and Development, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Kinematics, Fault (geology), 010502 geochemistry & geophysics, 01 natural sciences, Surface faulting, geological prompt surveys, lcsh:G3180-9980, Earth and Planetary Sciences (miscellaneous), coseismic ruptures, normal faulting, 2016–2017 seismic sequence, central Italy, Coseismic rupture, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, lcsh:Maps, [SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics, Geological prompt survey, 2016-2017 seismic sequence, Geological prompt surveys, Normal faulting, Coseismic ruptures, Central Italy, geography, geography.geographical_feature_category, Oblique case, [ SDU.STU ] Sciences of the Universe [physics]/Earth Sciences, es, 13. Climate action, Geology, Seismology
Abstract

We present a 1:25,000 scale map of the coseismic surface ruptures following the 30 October 2016 M-w 6.5 Norcia normal-faulting earthquake, central Italy. Detailed rupture mapping is based on almost 11,000 oblique photographs taken from helicopter flights, that has been verified and integrated with field data (>7000 measurements). Thanks to the common efforts of the Open EMERGEO Working Group (130 people, 25 research institutions and universities from Europe), we were able to document a complex surface faulting pattern with a dominant strike of N135 degrees-160 degrees (SW-dipping) and a subordinate strike of N320 degrees-345 degrees (NE-dipping) along about 28km of the active Mt. Vettore-Mt. Bove fault system. Geometric and kinematic characteristics of the rupture were observed and recorded along closely spaced, parallel or subparallel, overlapping or step-like synthetic and antithetic fault splays of the activated fault systems, comprising a total surface rupture length of approximately 46km when all ruptures were considered.

Published
2018
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20. Correction: A database of the coseismic effects following the 30 October 2016 Norcia earthquake in central Italy (Scientific Data, (2018) 5, 10.1038/sdata.2018.49)

Author

Villani, F., Civico, R., Pucci, S., Pizzimenti, L., Nappi, R., De Martini, P. M., Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A. M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C. A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F. R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falconi, L., Falcucci, E., Farabollini, P., Faure Walker, J. P., Ferrarini, F., Ferrario, M. F., Ferry, M., Feuillet, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L. C., Guerrieri, L., Hailemikael, S., Hollingsworth, J., Iezzi, F., Invernizzi, C., Jablonska, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Lo Sardo, L., Malet, J. P., Mariucci, M. T., Materazzi, M., Maubant, L., Mazzarini, F., Mccaffrey, K. J. W., Michetti, A. M., Mildon, Z. K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Perouse, E., Pezzo, G., Piccardi, L., Pierantoni, P. P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pousse, L., Pozzi, A., Proposito, M., Puglisi, C., Puliti, I., Ricci, T., Ripamonti, L., Rizza, M., Roberts, G. P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Socquet, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L. N. J., Wilkinson, M., and Zambrano, M.

Published
2019

21. HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with different HCV-RNA levels

Author

Di Maio, V C, Cento, V, Di Paolo, D, Aragri, M, De Leonardis, F, Tontodonati, M, Micheli, V, Bellocchi, M C, Antonucci, F P, Bertoli, A, Lenci, I, Milana, M, Gianserra, L, Melis, M, Di Biagio, A, Sarrecchia, C, Sarmati, L, Landonio, S, Francioso, S, Lambiase, L, Nicolini, L A, Marenco, S, Nosotti, L, Giannelli, V, Siciliano, M, Romagnoli, D, Pellicelli, A, Vecchiet, J, Magni, C F, Babudieri, S, Mura, M S, Taliani, G, Mastroianni, C, Vespasiani-Gentilucci, U, Romano, M, Morisco, F, Gasbarrini, A, Vullo, V, Bruno, S, Baiguera, C, Pasquazzi, C, Tisone, G, Picciotto, A, Andreoni, M, Parruti, G, Rizzardini, G, Angelico, M, Perno, C F, Ceccherini-Silberstein, F, Collaborators (129) Mariani R, HCV Italian Resistance Network Study Group., Paoloni, M, Iapadre, N, Grimaldi, A, Menzaghi, B, Quirino, T, Bruzzone, B, De Maria, A, Nicolini, La, Viscoli, C, Casinelli, K, Monache, Md, Lichtner, M, Aghemo, A, Cerrone, M, Colombo, M, Monforte, Ad, Danieli, E, Donato, F, Gubertini, G, Magni, Cf, Mancon, A, Monico, S, Niero, F, Puoti, M, Russo, Ml, Alfieri, R, Gnocchi, M, Orro, A, Milanesi, L, Baldelli, E, Bertolotti, M, Borghi, V, Mussini, C, Brancaccio, G, Caporaso, N, Gaeta, Gb, Lembo, V, Calvaruso, V, Craxì, A, Di Marco, V, Mazzola, A, Petta, S, D'Amico, E, Cacciatore, P, Consorte, A, Palitti, Vp, Pieri, A, Polilli, E, Antenucci, F, Antonucci, Fp, Armenia, D, Baiocchi, L, Bellocchi, M, Biliotti, E, Biolato, M, Carioti, L, Cerasari, G, Cerva, C, Ciotti, M, D'Ambrosio, C, D'Ettorre, G, De Sanctis, A, Di Maio VC, Furlan, C, Gallo, P, Grieco, A, Grieco, S, Lattanzi, B, Malagnino, V, Manuelli, M, Merli, M, Miglioresi, L, Palazzo, D, Perno, Cf, Santopaolo, F, Santoro, Mm, Sforza, D, Sorbo, Mc, Spaziante, M, Svicher, V, Teti, E, Mangia, A, Maida, I, Mura, Ms, Falconi, L, Di Giammartino, D, Tarquini, P., Di Maio, V C, Cento, V, Di Paolo, D, Aragri, M, De Leonardis, F, Tontodonati, M, Micheli, V, Bellocchi, M C, Antonucci, F P, Bertoli, A, Lenci, I, Milana, M, Gianserra, L, Melis, M, Di Biagio, A, Sarrecchia, C, Sarmati, L, Landonio, S, Francioso, S, Lambiase, L, Nicolini, L A, Marenco, S, Nosotti, L, Giannelli, V, Siciliano, M, Romagnoli, D, Pellicelli, A, Vecchiet, J, Magni, C F, Babudieri, S, Mura, M S, Taliani, G, Mastroianni, C, Vespasiani-Gentilucci, U, Romano, M, Morisco, F, Gasbarrini, A, Vullo, V, Bruno, S, Baiguera, C, Pasquazzi, C, Tisone, G, Picciotto, A, Andreoni, M, Parruti, G, Rizzardini, G, Angelico, M, Perno, C F, Ceccherini-Silberstein, F, HCV Italian Resistance Network Study Group., Collaborators (129) Mariani R, Paoloni, M, Iapadre, N, Grimaldi, A, Menzaghi, B, Quirino, T, Bruzzone, B, De Maria, A, Nicolini, La, Viscoli, C, Casinelli, K, Monache, Md, Lichtner, M, Aghemo, A, Cerrone, M, Colombo, M, Monforte, Ad, Danieli, E, Donato, F, Gubertini, G, Magni, Cf, Mancon, A, Monico, S, Niero, F, Puoti, M, Russo, Ml, Alfieri, R, Gnocchi, M, Orro, A, Milanesi, L, Baldelli, E, Bertolotti, M, Borghi, V, Mussini, C, Brancaccio, G, Caporaso, N, Gaeta, Gb, Lembo, V, Calvaruso, V, Craxì, A, Di Marco, V, Mazzola, A, Petta, S, D'Amico, E, Cacciatore, P, Consorte, A, Palitti, Vp, Pieri, A, Polilli, E, Antenucci, F, Antonucci, Fp, Armenia, D, Baiocchi, L, Bellocchi, M, Biliotti, E, Biolato, M, Carioti, L, Cerasari, G, Cerva, C, Ciotti, M, D'Ambrosio, C, D'Ettorre, G, De Sanctis, A, Di Maio, Vc, Furlan, C, Gallo, P, Grieco, A, Grieco, S, Lattanzi, B, Malagnino, V, Manuelli, M, Merli, M, Miglioresi, L, Palazzo, D, Perno, Cf, Santopaolo, F, Santoro, Mm, Sforza, D, Sorbo, Mc, Spaziante, M, Svicher, V, Teti, E, Mangia, A, Maida, I, Mura, M, Falconi, L, Di Giammartino, D, Tarquini, P., Di Maio, V. C, Bellocchi, M. C, Antonucci, F. P, Nicolini, L. A, Magni, C. F, Mura, M. S, Vespasiani Gentilucci, U, Morisco, Filomena, Perno, C. F, Ceccherini Silberstein, F., Caporaso, Nicola, Di Maio, V., Cento, V., Di Paolo, D., Aragri, M., De Leonardis, F., Tontodonati, M., Micheli, V., Bellocchi, M., Antonucci, F., Bertoli, A., Lenci, I., Milana, M., Gianserra, L., Melis, M., Di Biagio, A., Sarrecchia, C., Sarmati, L., Landonio, S., Francioso, S., Lambiase, L., Nicolini, L., Marenco, S., Nosotti, L., Giannelli, V., Siciliano, M., Romagnoli, D., Pellicelli, A., Vecchiet, J., Magni, C., Babudieri, S., Mura, M., Taliani, G., Mastroianni, C., Vespasiani-Gentilucci, U., Romano, M., Morisco, F., Gasbarrini, A., Vullo, V., Bruno, S., Baiguera, C., Pasquazzi, C., Tisone, G., Picciotto, A., Andreoni, M., Parruti, G., Rizzardini, G., Angelico, M., Perno, C., Ceccherini-Silberstein, F., Mariani, R., Paoloni, M., Iapadre, N., Grimaldi, A., Menzaghi, B., Quirino, T., Bruzzone, B., De Maria, A., Viscoli, C., Casinelli, K., Delle Monache, M., Lichtner, M., Aghemo, A., Cerrone, M., Colombo, M., D'Arminio Monforte, A., Danieli, E., Donato, F., Gubertini, G., Mancon, A., Monico, S., Niero, F., Puoti, M., Russo, M., Alfieri, R., Gnocchi, M., Orro, A., Milanesi, L., Baldelli, E., Bertolotti, M., Borghi, V., Mussini, C., Brancaccio, G., Caporaso, N., Gaeta, G., Lembo, V., Calvaruso, V., Craxã­, A., DI MARCO, V., Mazzola, A., Petta, S., D'Amico, E., Cacciatore, P., Consorte, A., Pace Palitti, V., Pieri, A., Polilli, E., Antenucci, F., Armenia, D., Baiocchi, L., Biliotti, E., Biolato, M., Carioti, L., Cerasari, G., Cerva, C., Ciotti, M., D'Ambrosio, C., D'Ettorre, G., De Sanctis, A., Furlan, C., Gallo, P., Grieco, A., Grieco, S., Lattanzi, B., Malagnino, V., Manuelli, M., Merli, M., Miglioresi, L., Palazzo, D., Santopaolo, F., Santoro, M., Sforza, D., Sorbo, M., Spaziante, M., Svicher, V., Teti, E., Mangia, A., Maida, I., Falconi, L., and Di Giammartino, D.

Subjects
0301 basic medicine, ns3, Genotyping Techniques, viruses, Drug Resistance, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Gastroenterology, Telaprevir, chemistry.chemical_compound, genotype, genotyping techniques, hepacivirus, hepatitis C, humans, RNA viral, retrospective studies, sequence analysis, DNA, viral nonstructural proteins, drug resistance, viral, mutation, pharmacology, infectious diseases, 0302 clinical medicine, Retrospective Studie, Genotype, Pharmacology (medical), Viral, Hepatitis C, Humans, RNA, Viral, Retrospective Studies, Sequence Analysis, DNA, Drug Resistance, Viral, Mutation, Proteolytic enzymes, virus diseases, Settore MED/07 - Microbiologia e Microbiologia Clinica, hcv-rna levels, Infectious Diseases, HCV-RNA, 030211 gastroenterology & hepatology, Sequence Analysis, medicine.drug, Human, Microbiology (medical), medicine.medical_specialty, Hepatitis C virus, Concordance, Settore MED/12 - GASTROENTEROLOGIA, Pharmacology, Biology, 03 medical and health sciences, Boceprevir, Internal medicine, medicine, hcv, Genotyping, Hepaciviru, Viral Nonstructural Protein, Settore MED/09 - MEDICINA INTERNA, Virology, digestive system diseases, 030104 developmental biology, chemistry, Sequence Analysi, RNA, Genotyping Technique
Abstract

OBJECTIVES: This study aims to evaluate the reliability and clinical utility of NS3 sequencing in hepatitis C virus (HCV) 1-infected patients who were candidates to start a PI-containing regimen. METHODS: NS3 protease sequencing was performed by in-house-developed HCV-1 subtype-specific protocols. Phylogenetic analysis was used to test sequencing reliability and concordance with previous genotype/subtype assignment by commercial genotyping assays. RESULTS: Five hundred and sixty-seven HCV plasma samples with quantifiable HCV-RNA from 326 HCV-infected patients were collected between 2011 and 2014. Overall, the success rate of NS3 sequencing was 88.9%. The success rate between the two subtype protocols (HCV-1a/HCV-1b) was similarly high for samples with HCV-RNA >3 log IU/mL (>92% success rate), while it was slightly lower for HCV-1a samples with HCV-RNA ≤3 log IU/mL compared with HCV-1b samples. Phylogenetic analysis confirmed the genotype/subtype given by commercial genotyping assays in 92.9% (303/326) of cases analysed. In the remaining 23 cases (7.1%), 1 was HCV-1g (previously defined as subtype 1a), 1 was HCV-4d (previously defined as genotype 1b) and 1 was HCV-1b (previously defined as genotype 2a/2c). In the other cases, NS3 sequencing precisely resolved the either previous undetermined/discordant subtype 1 or double genotype/subtype assignment by commercial genotyping assays. Resistance-associated variants (RAVs) to PI were detected in 31.0% of samples. This prevalence changed according to PI experience (17.1% in PI-naive patients versus 79.2% in boceprevir/telaprevir/simeprevir-failing patients). Among 96 patients with available virological outcome following boceprevir/telaprevir treatment, a trend of association between baseline NS3 RAVs and virological failure was observed (particularly for HCV-1a-infected patients: 3/21 failing patients versus 0/22 achieving sustained virological response; P = 0.11). CONCLUSIONS: HCV-NS3 sequencing provides reliable results and at the same time gives two clinically relevant pieces of information: a correct subtype/genotype assignment and the detection of variants that may interfere with the efficacy of PI.

Published
2016
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22. Multiclass HCV resistance to direct-acting antiviral failure in real-life patients advocates for tailored second-line therapies

Author

Di Maio, Velia C., Cento, Valeria, Lenci, Ilaria, Aragri, Marianna, Rossi, Piera, Barbaliscia, Silvia, Melis, Michela, Verucchi, Gabriella, Magni, Carlo F., Teti, Elisabetta, Bertoli, Ada, Antonucci, Francescopaolo, Bellocchi, Maria C., Micheli, Valeria, Masetti, Chiara, Landonio, Simona, Francioso, Simona, Santopaolo, Francesco, Pellicelli, Adriano M., Calvaruso, Vincenza, Gianserra, Laura, Siciliano, Massimo, Romagnoli, Dante, Cozzolongo, Raffaele, Grieco, Antonio, Vecchiet, Jacopo, Morisco, Filomena, Merli, Manuela, Brancaccio, Giuseppina, Di Biagio, Antonio, Loggi, Elisabetta, Mastroianni, Claudio Maria, Pace Palitti, Valeria, Tarquini, Pierluigi, Puoti, Massimo, Taliani, Gloria, Sarmati, Loredana, Picciotto, Antonino, Vullo, Vincenzo, Caporaso, Nicola, Paoloni, Maurizio, Pasquazzi, Caterina, Rizzardini, Giuliano, Parruti, Giustino, Craxì, Antonio, Babudieri, Sergio, Andreoni, Massimo, Angelico, Mario, Perno, Carlo F., Ceccherini Silberstein, Francesca, Mariani, R., Iapadre, N., Grimaldi, A., Cozzolongo, R., Andreone, P., Verucchi, G., Menzaghi, B., Quirino, T., Pisani, V., Torti, MARIA CHIARA, Vecchiet, J., Bruzzone, B., De Maria, A., Marenco, S., Nicolini, L. A., Viscoli, C., Casinelli, K., Delle Monache, M., Lichtner, Miriam, Aghemo, A., Boccaccio, V., Bruno, S., Cerrone, M., Colombo, M., D'Arminio Monforte, A., Danieli, E., Donato, F., Gubertini, G., Lleo, A., Magni, C. F., Mancon, A., Monico, S., Niero, F., Russo, M. L., Gnocchi, M., Orro, A., Milanesi, L., Baldelli, E., Bertolotti, M., Borghi, V., Mussini, C., Brancaccio, G., Gaeta, G. B., Lembo, V., Sangiovanni, V., Di Marco, V., Mazzola, A., Petta, S., D'Amico, E., Cacciatore, P., Consorte, A., Pieri, A., Polilli, E., Sozio, F., Antenucci, F., Aragri, M., Baiocchi, L., Barbaliscia, S., Biliotti, Elisa, Biolato, M., Carioti, L., Ceccherini Silberstein, F., Cerasari, G., Cerva, C., Ciotti, M., D'Ambrosio, C., D'Ettorre, G., De Leonardis, F., De Sanctis, A., Di Maio, V. C., Di Paolo, D., Furlan, Caterina, Gallo, P., Gasbarrini, A., Giannelli, V., Grieco, S., Lambiase, L., Lattanzi, B., Lenci, I., Lula, R., Malagnino, V., Manuelli, M., Miglioresi, L., Milana, M., Moretti, A., Nosotti, L., Palazzo, Donatella, Pellicelli, A., Romano, M., Sarrecchia, C., Sforza, D., Sorbo, M. C., Spaziante, M., Svicher, V., Tisone, G., Vespasiani Gentilucci, U., D'Adamo, G., Mangia, A., Maida, I., Mura, M. S., Falconi, L., Di Giammartino, D., Di Maio, V., Cento, V., Lenci, I., Aragri, M., Rossi, P., Barbaliscia, S., Melis, M., Verucchi, G., Magni, C., Teti, E., Bertoli, A., Antonucci, F., Bellocchi, M., Micheli, V., Masetti, C., Landonio, S., Francioso, S., Santopaolo, F., Pellicelli, A., Calvaruso, V., Gianserra, L., Siciliano, M., Romagnoli, D., Cozzolongo, R., Grieco, A., Vecchiet, J., Morisco, F., Merli, M., Brancaccio, G., Di Biagio, A., Loggi, E., Mastroianni, C., Pace Palitti, V., Tarquini, P., Puoti, M., Taliani, G., Sarmati, L., Picciotto, A., Vullo, V., Caporaso, N., Paoloni, M., Pasquazzi, C., Rizzardini, G., Parruti, G., Craxã¬, A., Babudieri, S., Andreoni, M., Angelico, M., Perno, C., Ceccherini-Silberstein, F., Mariani, R., Iapadre, N., Grimaldi, A., Andreone, P., Menzaghi, B., Quirino, T., Pisani, V., Torti, C., Bruzzone, B., De Maria, A., Marenco, S., Nicolini, L., Viscoli, C., Casinelli, K., Delle Monache, M., Lichtner, M., Aghemo, A., Boccaccio, V., Bruno, S., Cerrone, M., Colombo, M., D'Arminio Monforte, A., Danieli, E., Donato, F., Gubertini, G., Lleo, A., Mancon, A., Monico, S., Niero, F., Russo, M., Gnocchi, M., Orro, A., Milanesi, L., Baldelli, E., Bertolotti, M., Borghi, V., Mussini, C., Gaeta, G., Lembo, V., Sangiovanni, V., DI MARCO, V., Mazzola, A., Petta, S., D'Amico, E., Cacciatore, P., Consorte, A., Pieri, A., Polilli, E., Sozio, F., Antenucci, F., Baiocchi, L., Biliotti, E., Biolato, M., Carioti, L., Cerasari, G., Cerva, C., Ciotti, M., D'Ambrosio, C., D'Ettorre, G., De Leonardis, F., De Sanctis, A., Di Paolo, D., Furlan, C., Gallo, P., Gasbarrini, A., Giannelli, V., Grieco, S., Lambiase, L., Lattanzi, B., Lula, R., Malagnino, V., Manuelli, M., Miglioresi, L., Milana, M., Moretti, A., Nosotti, L., Palazzo, D., Romano, M., Sarrecchia, C., Sforza, D., Sorbo, M., Spaziante, M., Svicher, V., Tisone, G., Vespasiani-Gentilucci, U., D'Adamo, G., Mangia, A., Maida, I., Mura, M., Falconi, L., Di Giammartino, D., Di Maio, V, Cento, V, Lenci, I, Aragri, M, Rossi, P, Barbaliscia, S, Melis, M, Verucchi, G, Magni, C, Teti, E, Bertoli, A, Antonucci, F, Bellocchi, M, Micheli, V, Masetti, C, Landonio, S, Francioso, S, Santopaolo, F, Pellicelli, A, Calvaruso, V, Gianserra, L, Siciliano, M, Romagnoli, D, Cozzolongo, R, Grieco, A, Morisco, F, Merli, M, Brancaccio, G, Di Biagio, A, Loggi, E, Mastroianni, C, Pace Palitti, V, Tarquini, P, Puoti, M, Taliani, G, Sarmati, L, Picciotto, A, Vullo, V, Caporaso, N, Paoloni, M, Pasquazzi, C, Rizzardini, G, Parruti, G, Craxì, A, Babudieri, S, Andreoni, M, Angelico, M, Perno, C, Ceccherini-Silberstein, F, Velia C. Di Maio, Valeria Cento, Ilaria Lenci, Marianna Aragri, Piera Rossi, Silvia Barbaliscia, Michela Meli, Gabriella Verucchi, Carlo F. Magni, Elisabetta Teti, Ada Bertoli, Francesco Paolo Antonucci, Maria C. Bellocchi, Valeria Micheli, Chiara Masetti, Simona Landonio, Simona Francioso, Francesco Santopaolo, Adriano M. Pellicelli, Vincenza Calvaruso, Laura Gianserra, Massimo Siciliano, Dante Romagnoli, Raffaele Cozzolongo, Antonio Grieco, Jacopo Vecchiet, Filomena Morisco, Manuela Merli, Giuseppina Brancaccio, Antonio Di Biagio, Elisabetta Loggi, Claudio M. Mastroianni, Valeria Pace Palitti, Pierluigi Tarquini, Massimo Puoti, Gloria Taliani, Loredana Sarmati, Antonino Picciotto, Vincenzo Vullo, Nicola Caporaso, Maurizio Paoloni, Caterina Pasquazzi, Giuliano Rizzardini, Giustino Parruti, Antonio Craxì, Sergio Babudieri, Massimo Andreoni, Mario Angelico, Carlo F. Perno, Francesca Ceccherini-Silberstein, for the HCV Italian Resistance Network Study Group: [.., P. Andreone, E. Loggi, G. Verucchi, ], Di Maio, Velia C., Cento, Valeria, Lenci, Ilaria, Aragri, Marianna, Rossi, Piera, Barbaliscia, Silvia, Melis, Michela, Verucchi, Gabriella, Magni, Carlo F., Teti, Elisabetta, Bertoli, Ada, Antonucci, Francescopaolo, Bellocchi, Maria C., Micheli, Valeria, Masetti, Chiara, Landonio, Simona, Francioso, Simona, Santopaolo, Francesco, Pellicelli, Adriano M., Calvaruso, Vincenza, Gianserra, Laura, Siciliano, Massimo, Romagnoli, Dante, Cozzolongo, Raffaele, Grieco, Antonio, Vecchiet, Jacopo, Morisco, Filomena, Merli, Manuela, Brancaccio, Giuseppina, Di Biagio, Antonio, Loggi, Elisabetta, Mastroianni, Claudio M., Pace Palitti, Valeria, Tarquini, Pierluigi, Puoti, Massimo, Taliani, Gloria, Sarmati, Loredana, Picciotto, Antonino, Vullo, Vincenzo, Caporaso, Nicola, Paoloni, Maurizio, Pasquazzi, Caterina, Rizzardini, Giuliano, Parruti, Giustino, Craxã¬, Antonio, Babudieri, Sergio, Andreoni, Massimo, Angelico, Mario, Perno, Carlo F., Ceccherini-Silberstein, Francesca, Nicolini, L. A., Magni, C. F., Russo, M. L., Gaeta, G. B., Di Marco, V., Di Maio, V. C., Sorbo, M. C., Mura, M. S., Di Maio, Velia C, Magni, Carlo F, Bellocchi, Maria C, Pellicelli, Adriano M, Mastroianni, Claudio M, Craxì, Antonio, Perno, Carlo F, and Ceccherini Silberstein, Francesca

Subjects
Male, 0301 basic medicine, hepatitis C virus, Sustained Virologic Response, Sofosbuvir, Hepacivirus, Drug Resistance, resistance-associated substitutions, Viral Nonstructural Proteins, VARIANTS, NS5A, medicine.disease_cause, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Recurrence, INFECTION, antiviral therapy, Medicine, hepatitis C viru, Viral, Treatment Failure, Chronic, direct-acting antivirals, resistance test, hepatology, biology, GENOTYPE 1, virus diseases, Middle Aged, Settore MED/07 - Microbiologia e Microbiologia Clinica, Hepatitis C, Italy, Combination, Interferon, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, Author Keywords:antiviral therapy, RIBAVIRIN, Sequence Analysis, Human, medicine.drug, medicine.medical_specialty, Daclatasvir, Genotype, Hepatitis C virus, Antiviral Agents, LONG-TERM PERSISTENCE, DACLATASVIR, 03 medical and health sciences, Drug Therapy, Aged, Drug Resistance, Viral, Hepatitis C, Chronic, Humans, Interferons, Mutation, Ribavirin, Sequence Analysis, DNA, Hepatology, TREATMENT-NAIVE, Internal medicine, Antiviral Agent, resistance-associated substitution, direct-acting antiviral, Hepaciviru, resistance test KeyWords Plus:HEPATITIS-C VIRUS, business.industry, Viral Nonstructural Protein, DNA, biology.organism_classification, Clinical trial, 030104 developmental biology, SOFOSBUVIR, chemistry, Sequence Analysi, Immunology, business
Abstract

Background & Aims: Despite the excellent efficacy of direct-acting antivirals (DAA) reported in clinical trials, virological failures can occur, often associated with the development of resistance-associated substitutions (RASs). This study aimed to characterize the presence of clinically relevant RASs to all classes in real-life DAA failures. Methods: Of the 200 virological failures that were analyzed in 197 DAA-treated patients, 89 with pegylated-interferon+ribavirin (PegIFN+RBV) and 111 without (HCV-1a/1b/1g/2/3/4=58/83/1/6/24/25; 56.8% treatment experienced; 65.5% cirrhotic) were observed. Sanger sequencing of NS3/NS5A/NS5B was performed by home-made protocols, at failure (N= 200) and whenever possible at baseline (N= 70). Results: The majority of the virological failures were relapsers (57.0%), 22.5% breakthroughs, 20.5% non-responders. RAS prevalence varied according to IFN/RBV use, DAA class, failure type and HCV genotype/subtype. It was 73.0% in IFN group vs 49.5% in IFN free, with the highest prevalence of NS5A-RASs (96.1%), compared to NS3-RASs (75.9% with IFN, 70.5% without) and NS5B-RASs (66.6% with IFN, 20.4% without, in sofosbuvir failures). In the IFN-free group, RASs were higher in breakthrough/non-responders than in relapsers (90.5% vs 40.0%, P= 2 DAA classes showed multiclass resistance, including 11/11 NS3+NS5A failures. Furthermore, 20.0% of patients had baseline-RASs, which were always confirmed at failure. Conclusions: In our failure setting, RAS prevalence was remarkably high in all genes, with a partial exception for NS5B, whose limited resistance is still higher than previously reported. This multiclass resistance advocates for HCV resistance testing at failure, in all three genes for the best second-line therapeutic tailoring.

Published
2017
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23. HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with different HCV-RNA levels

Author

Di Maio, V, Cento, V, Di Paolo, D, Aragri, M, De Leonardis, F, Tontodonati, M, Micheli, V, Bellocchi, M, Antonucci, F, Bertoli, A, Lenci, I, Milana, M, Gianserra, L, Melis, M, Di Biagio, A, Sarrecchia, C, Sarmati, L, Landonio, S, Francioso, S, Lambiase, L, Nicolini, L, Marenco, S, Nosotti, L, Giannelli, V, Siciliano, M, Romagnoli, D, Pellicelli, A, Vecchiet, J, Magni, C, Babudieri, S, Mura, M, Taliani, G, Mastroianni, C, Vespasiani-Gentilucci, U, Romano, M, Morisco, F, Gasbarrini, A, Vullo, V, Bruno, S, Baiguera, C, Pasquazzi, C, Tisone, G, Picciotto, A, Andreoni, M, Parruti, G, Rizzardini, G, Angelico, M, Perno, C, Ceccherini-Silberstein, F, Mariani, R, Paoloni, M, Iapadre, N, Grimaldi, A, Menzaghi, B, Quirino, T, Bruzzone, B, De Maria, A, Viscoli, C, Casinelli, K, Delle Monache, M, Lichtner, M, Aghemo, A, Cerrone, M, Colombo, M, D'Arminio Monforte, A, Danieli, E, Donato, F, Gubertini, G, Mancon, A, Monico, S, Niero, F, Puoti, M, Russo, M, Alfieri, R, Gnocchi, M, Orro, A, Milanesi, L, Baldelli, E, Bertolotti, M, Borghi, V, Mussini, C, Brancaccio, G, Caporaso, N, Gaeta, G, Lembo, V, Calvaruso, V, Craxi, A, Di Marco, V, Mazzola, A, Petta, S, D'Amico, E, Cacciatore, P, Consorte, A, Pace Palitti, V, Pieri, A, Polilli, E, Antenucci, F, Armenia, D, Baiocchi, L, Biliotti, E, Biolato, M, Carioti, L, Cerasari, G, Cerva, C, Ciotti, M, D'Ambrosio, C, D'Ettorre, G, De Sanctis, A, Furlan, C, Gallo, P, Grieco, A, Grieco, S, Lattanzi, B, Malagnino, V, Manuelli, M, Merli, M, Miglioresi, L, Palazzo, D, Santopaolo, F, Santoro, M, Sforza, D, Sorbo, M, Spaziante, M, Svicher, V, Teti, E, Mangia, A, Maida, I, Falconi, L, Di Giammartino, D, Tarquini, P, Di Maio V. C., Cento V., Di Paolo D., Aragri M., De Leonardis F., Tontodonati M., Micheli V., Bellocchi M. C., Antonucci F. P., Bertoli A., Lenci I., Milana M., Gianserra L., Melis M., Di Biagio A., Sarrecchia C., Sarmati L., Landonio S., Francioso S., Lambiase L., Nicolini L. A., Marenco S., Nosotti L., Giannelli V., Siciliano M., Romagnoli D., Pellicelli A., Vecchiet J., Magni C. F., Babudieri S., Mura M. S., Taliani G., Mastroianni C., Vespasiani-Gentilucci U., Romano M., Morisco F., Gasbarrini A., Vullo V., Bruno S., Baiguera C., Pasquazzi C., Tisone G., Picciotto A., Andreoni M., Parruti G., Rizzardini G., Angelico M., Perno C. F., Ceccherini-Silberstein F., Mariani R., Paoloni M., Iapadre N., Grimaldi A., Menzaghi B., Quirino T., Bruzzone B., De Maria A., Viscoli C., Casinelli K., Delle Monache M., Lichtner M., Aghemo A., Cerrone M., Colombo M., D'Arminio Monforte A., Danieli E., Donato F., Gubertini G., Mancon A., Monico S., Niero F., Puoti M., Russo M. L., Alfieri R., Gnocchi M., Orro A., Milanesi L., Baldelli E., Bertolotti M., Borghi V., Mussini C., Brancaccio G., Caporaso N., Gaeta G. B., Lembo V., Calvaruso V., Craxi A., Di Marco V., Mazzola A., Petta S., D'Amico E., Cacciatore P., Consorte A., Pace Palitti V., Pieri A., Polilli E., Antenucci F., Armenia D., Baiocchi L., Biliotti E., Biolato M., Carioti L., Cerasari G., Cerva C., Ciotti M., D'Ambrosio C., D'Ettorre G., De Sanctis A., Furlan C., Gallo P., Grieco A., Grieco S., Lattanzi B., Malagnino V., Manuelli M., Merli M., Miglioresi L., Palazzo D., Santopaolo F., Santoro M. M., Sforza D., Sorbo M. C., Spaziante M., Svicher V., Teti E., Mangia A., Maida I., Falconi L., Di Giammartino D., Tarquini P., Di Maio, V, Cento, V, Di Paolo, D, Aragri, M, De Leonardis, F, Tontodonati, M, Micheli, V, Bellocchi, M, Antonucci, F, Bertoli, A, Lenci, I, Milana, M, Gianserra, L, Melis, M, Di Biagio, A, Sarrecchia, C, Sarmati, L, Landonio, S, Francioso, S, Lambiase, L, Nicolini, L, Marenco, S, Nosotti, L, Giannelli, V, Siciliano, M, Romagnoli, D, Pellicelli, A, Vecchiet, J, Magni, C, Babudieri, S, Mura, M, Taliani, G, Mastroianni, C, Vespasiani-Gentilucci, U, Romano, M, Morisco, F, Gasbarrini, A, Vullo, V, Bruno, S, Baiguera, C, Pasquazzi, C, Tisone, G, Picciotto, A, Andreoni, M, Parruti, G, Rizzardini, G, Angelico, M, Perno, C, Ceccherini-Silberstein, F, Mariani, R, Paoloni, M, Iapadre, N, Grimaldi, A, Menzaghi, B, Quirino, T, Bruzzone, B, De Maria, A, Viscoli, C, Casinelli, K, Delle Monache, M, Lichtner, M, Aghemo, A, Cerrone, M, Colombo, M, D'Arminio Monforte, A, Danieli, E, Donato, F, Gubertini, G, Mancon, A, Monico, S, Niero, F, Puoti, M, Russo, M, Alfieri, R, Gnocchi, M, Orro, A, Milanesi, L, Baldelli, E, Bertolotti, M, Borghi, V, Mussini, C, Brancaccio, G, Caporaso, N, Gaeta, G, Lembo, V, Calvaruso, V, Craxi, A, Di Marco, V, Mazzola, A, Petta, S, D'Amico, E, Cacciatore, P, Consorte, A, Pace Palitti, V, Pieri, A, Polilli, E, Antenucci, F, Armenia, D, Baiocchi, L, Biliotti, E, Biolato, M, Carioti, L, Cerasari, G, Cerva, C, Ciotti, M, D'Ambrosio, C, D'Ettorre, G, De Sanctis, A, Furlan, C, Gallo, P, Grieco, A, Grieco, S, Lattanzi, B, Malagnino, V, Manuelli, M, Merli, M, Miglioresi, L, Palazzo, D, Santopaolo, F, Santoro, M, Sforza, D, Sorbo, M, Spaziante, M, Svicher, V, Teti, E, Mangia, A, Maida, I, Falconi, L, Di Giammartino, D, Tarquini, P, Di Maio V. C., Cento V., Di Paolo D., Aragri M., De Leonardis F., Tontodonati M., Micheli V., Bellocchi M. C., Antonucci F. P., Bertoli A., Lenci I., Milana M., Gianserra L., Melis M., Di Biagio A., Sarrecchia C., Sarmati L., Landonio S., Francioso S., Lambiase L., Nicolini L. A., Marenco S., Nosotti L., Giannelli V., Siciliano M., Romagnoli D., Pellicelli A., Vecchiet J., Magni C. F., Babudieri S., Mura M. S., Taliani G., Mastroianni C., Vespasiani-Gentilucci U., Romano M., Morisco F., Gasbarrini A., Vullo V., Bruno S., Baiguera C., Pasquazzi C., Tisone G., Picciotto A., Andreoni M., Parruti G., Rizzardini G., Angelico M., Perno C. F., Ceccherini-Silberstein F., Mariani R., Paoloni M., Iapadre N., Grimaldi A., Menzaghi B., Quirino T., Bruzzone B., De Maria A., Viscoli C., Casinelli K., Delle Monache M., Lichtner M., Aghemo A., Cerrone M., Colombo M., D'Arminio Monforte A., Danieli E., Donato F., Gubertini G., Mancon A., Monico S., Niero F., Puoti M., Russo M. L., Alfieri R., Gnocchi M., Orro A., Milanesi L., Baldelli E., Bertolotti M., Borghi V., Mussini C., Brancaccio G., Caporaso N., Gaeta G. B., Lembo V., Calvaruso V., Craxi A., Di Marco V., Mazzola A., Petta S., D'Amico E., Cacciatore P., Consorte A., Pace Palitti V., Pieri A., Polilli E., Antenucci F., Armenia D., Baiocchi L., Biliotti E., Biolato M., Carioti L., Cerasari G., Cerva C., Ciotti M., D'Ambrosio C., D'Ettorre G., De Sanctis A., Furlan C., Gallo P., Grieco A., Grieco S., Lattanzi B., Malagnino V., Manuelli M., Merli M., Miglioresi L., Palazzo D., Santopaolo F., Santoro M. M., Sforza D., Sorbo M. C., Spaziante M., Svicher V., Teti E., Mangia A., Maida I., Falconi L., Di Giammartino D., and Tarquini P.

Abstract

Objectives: This study aims to evaluate the reliability and clinical utility of NS3 sequencing in hepatitis C virus (HCV) 1-infected patients who were candidates to start a PI-containing regimen. Methods: NS3 protease sequencing was performed by in-house-developed HCV-1 subtype-specific protocols. Phylogenetic analysis was used to test sequencing reliability and concordance with previous genotype/subtype assignment by commercial genotyping assays. Results: Five hundred and sixty-seven HCV plasma samples with quantifiable HCV-RNA from 326 HCV-infected patients were collected between 2011 and 2014. Overall, the success rate of NS3 sequencing was 88.9%. The success rate between the two subtype protocols (HCV-1a/HCV-1b) was similarly high for samples with HCV-RNA > 3 log IU/mL (>92% success rate), while it was slightly lower for HCV-1a samples with HCV-RNA ≤ 3 log IU/mL compared with HCV-1b samples. Phylogenetic analysis confirmed the genotype/subtype given by commercial genotyping assays in 92.9% (303/326) of cases analysed. In the remaining 23 cases (7.1%), 1 was HCV-1g (previously defined as subtype 1a), 1 was HCV-4d (previously defined as genotype 1b) and 1 was HCV-1b (previously defined as genotype 2a/2c). In the other cases, NS3 sequencing precisely resolved the either previous undetermined/discordant subtype 1 or double genotype/subtype assignment by commercial genotyping assays. Resistance-associated variants (RAVs) to PI were detected in 31.0% of samples. This prevalence changed according to PI experience (17.1% in PI-naive patients versus 79.2% in boceprevir/telaprevir/simeprevir-failing patients). Among 96 patients with available virological outcome following boceprevir/telaprevir treatment, a trend of association between baseline NS3 RAVs and virological failure was observed (particularly for HCV-1a-infected patients: 3/21 failing patients versus 0/22 achieving sustained virological response; P = 0.11). Conclusions: HCV-NS3 sequencing provides reliable

Published
2016

25. Biodiversity redistribution under climate change: Impacts on ecosystems and human well-being

Author

Pecl, G.T., Araújo, Miguel B., Bell, J.D., Blanchard, Julia L., Bonebrake, T.C., Chen, I.C., Clark, T.D., Colwell, R.K., Danielsen, Finn, Evengård, Birgitta, Falconi, L., Ferrier, S., Frusher, S., García, R.A., Griffis, R.B., Hobday, A.J., Janion-Scheepers, C., Jarzyna, M.A., Jennings, S., Lenoir, J., Linnetved, H.I., Martin, V.Y., McCormack, P.C., McDonald, J., Mitchell, N.J., Mustonen, Tero, Pandolfi, J.M., Pettorelli, N., Popova, E., Robinson, S.A., Scheffers, B.R., Shaw, Justine, Sorte, C.J.B., Strugnell, J.M., Sunday, J.M., Tuanmu, M.N., Vergés, A., Villanueva, C., Wernberg, Thomas, Wapstra, E., Williams, S.E., Pecl, G.T., Araújo, Miguel B., Bell, J.D., Blanchard, Julia L., Bonebrake, T.C., Chen, I.C., Clark, T.D., Colwell, R.K., Danielsen, Finn, Evengård, Birgitta, Falconi, L., Ferrier, S., Frusher, S., García, R.A., Griffis, R.B., Hobday, A.J., Janion-Scheepers, C., Jarzyna, M.A., Jennings, S., Lenoir, J., Linnetved, H.I., Martin, V.Y., McCormack, P.C., McDonald, J., Mitchell, N.J., Mustonen, Tero, Pandolfi, J.M., Pettorelli, N., Popova, E., Robinson, S.A., Scheffers, B.R., Shaw, Justine, Sorte, C.J.B., Strugnell, J.M., Sunday, J.M., Tuanmu, M.N., Vergés, A., Villanueva, C., Wernberg, Thomas, Wapstra, E., and Williams, S.E.

Abstract

Distributions of Earth's species are changing at accelerating rates, increasingly driven by humanmediated climate change. Such changes are already altering the composition of ecological communities, but beyond conservation of natural systems, how and why does this matter? We review evidence that climate-driven species redistribution at regional to global scales affects ecosystem functioning, human well-being, and the dynamics of climate change itself. Production of natural resources required for food security, patterns of disease transmission, and processes of carbon sequestration are all altered by changes in species distribution. Consideration of these effects of biodiversity redistribution is critical yet lacking in most mitigation and adaptation strategies, including the United Nation's Sustainable Development Goals.

Published
2017

27. Periferia, parco, architettura': la penisola del Cavallino, Venezia, 1994

Author

Marras, Giovanni, Semerani, L., Gallo, A., Battaino, C., Falconi, L., Barbarewicz, P., Luciano Semerani, Gigetta Tamaro, Marras, Giovanni, Semerani, L., Gallo, A., Battaino, C., Falconi, L., and Barbarewicz, P.

Subjects
PARCO, LAGUNA, ARCHITETTURA, PAESAGGIO, VENEZIA, CITTA'
Published
2000

31. Exploring the ENEA Casaccia and ENEA Frascati irradiation capabilities: Status and perspectives

Author

Croia Michele, Burgio Nunzio, Ampollini Alessandro, Astorino Maria Denise, Bazzano Giulia, Bianchi Barbara, Cesaroni Mateo, Falconi Luca, Fiore Salvatore, Lepore Luigi, Nascetti Augusto, Nenzi Paolo, Pietropaolo Antonino, Ronsivalle Concetta, Santagata Alfonso, Ratto Antonino, Ricci Pierpaolo, and Scaramuzzo Luigi

Subjects
nuclear research reactor, particle accelerator physics, neutron generator, irradiation facility, aerospace, science material, beam dynamics, monte carlo simulations, Physics, QC1-999
Abstract

A collaboration between different facilities in Casaccia and Frascati ENEA research centers has recently opened the possibility of performing irradiation experiments using different kinds of particles such as protons, neutrons, and electrons. The facilities involved in the project are the TAPIRO fast nuclear research reactor, the TOP-IMPLART proton accelerator (71 MeV), the REX electron accelerator (5 MeV) and the FNG neutron facility (2.5/14 MeV). This suite of plans represents a distributed irradiation facility using different particles and spectra, offering various irradiation capabilities for experiments in many fields, such as: nuclear physics, accelerator physics, aerospace, science material, medicine, detectors, radiation diagnostics, etc. Complete numerical models of all the facilities have been implemented to perform start-to-end simulations before experimental irradiation using beam dynamics and nuclear transport simulation codes. In addition, our distributed irradiation facility makes it possible to recreate an essential part of the Van Allen Belt radiation allowing us to check the FLUKA quantitative calibration regarding this specific simulation, facilitating the disentanglements of the uncertainties. Finally, a comparison of the estimated silicon 1 MeV neutron equivalent fluence (SI1MEVNE) of the radiation damage imparted by the different facilities is presented.

Published
2023
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32. Seeing radioactivity: Gamma-ray imaging technique applied to TRIGA RC-1 Research Reactor in ENEA Casaccia

Author

Gagliardi Filippo, Ciotoli Alessandro, Gorello Edoardo, Meschini Luigi, Pagliuca Marco, Mauro Egidio, Cherubini Nadia, Lepore Luigi, Gandolfo Giada, Marzo Giuseppe A., Falconi Luca, Formenton Davide, and Roberti Andrea

Subjects
gamma imaging, triga research reactor, radiological survey, neutron sources, quantitative gamma spectrometry, nuclear decommissioning, waste management, Physics, QC1-999
Abstract

Current radiological characterization protocols applied in nuclear installations provide a valuable set of information used to assess level and distribution of radioactivity, which is a crucial information in the plant management. Nevertheless, typical routines may present limitations that novel technologies can alleviate. In this work, a new-generation 3D pixelated CdZnTe gamma imaging and spectrometer detector has been used at TRIGA RC-1 Research Reactor in ENEA Casaccia Research Centre to assess its performances in several possible tasks and effectively understand this technology readiness. In particular, three possible tasks have been considered: survey of potentially contaminated area (with determination of known and unknown hot spots), source identification and localization (including neutron sources via their gamma emissions), and quantification of isotope-specific activities in generic components thanks to the point-kernel-based algorithm the system is equipped with. The experience has demonstrated the capability to achieve reliable results in these tasks, with consequences that could impact not only the current characterization protocols but also the way some Nuclear Safeguards and Non-Proliferation operations are performed.

Published
2023
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39. Characterization of TRIGA RC-1 neutron irradiation facilities for radiation damage testing

Author

Davide Chiesa, Mauro Tacconi, Mario Carta, Pier-Giorgio Rancoita, Ezio Previtali, Angelo Grossi, V. Fabrizio, Luca Falconi, Massimiliano Nastasi, Stefano Pozzi, Barbara Ranghetti, Mario Palomba, Chiesa, D, Carta, M, Fabrizio, V, Falconi, L, Grossi, A, Nastasi, M, Palomba, M, Pozzi, S, Previtali, E, Rancoita, P, Ranghetti, B, Tacconi, M, Chiesa, D., Carta, M., Fabrizio, V., Falconi, L., Grossi, A., Nastasi, M., Palomba, M., Pozzi, S., Previtali, E., Rancoita, P. G., Ranghetti, B., and Tacconi, M.

Subjects
Materials science, Physics - Instrumentation and Detectors, 020209 energy, Nuclear engineering, Astrophysics::High Energy Astrophysical Phenomena, Spectrum unfolding, General Physics and Astronomy, Flux, FOS: Physical sciences, 02 engineering and technology, Neutron dose, Applied Physics (physics.app-ph), Neutron flux measurement, 01 natural sciences, TRIGA, Radiation damage, Gamma spectroscopy, Neutron flux, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Irradiation, Nuclear Experiment (nucl-ex), TRIGA Mark II reactor, Nuclear Experiment, Bayesian analysi, 010308 nuclear & particles physics, Physics - Applied Physics, Instrumentation and Detectors (physics.ins-det), Neutron activation, Intensity (heat transfer)
Abstract

This paper presents the results of neutron flux measurements at two irradiation facilities of the TRIGA Mark II reactor at ENEA Casaccia Research Center, Italy. The goal of these measurements is to provide a complete characterization of neutron irradiation facilities for accurate and precise dose evaluation in radiation damage tests and, more generally, for all applications that need a good knowledge of neutron flux in terms of intensity, energy spectrum and spatial distribution. The neutron activation technique is used to measure the activation rates of several reactions, chosen so to cover the whole energy range of neutron flux spectrum. A multi-group neutron flux measurement is obtained through an unfolding algorithm based on a Bayesian statistical model. The obtained results prove that this experimental method allows to measure the total neutron flux within 2% statistical uncertainty, and to get at the same time a good description of its energy spectrum and spatial distribution.

Published
2019
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40. SET UP OF A DETERMINISTIC CALCULATION MODEL FOR THE ANALYSIS OF FUSION-FISSION HYBRID SYSTEMS

Author

F. Panza, M. Carta, A. Cemmi, N. Cherubini, V. Fabrizio, L. Falconi, F. Filippi, G. Grasso, F. P. Orsitto, V. Peluso, Panza, F., Carta, M., Cemmi, A., Cherubini, N., Fabrizio, V., Falconi, L., Filippi, F., Grasso, G., Orsitto, F. P., and Peluso, V.

Subjects
Monte-Carlo codes, Nuclear and High Energy Physics, deterministic codes, Nuclear Energy and Engineering, FFHS, Condensed Matter Physics
Abstract

A simplified Fusion-Fission Hybrid System (FFHS) deterministic calculation model has been developed in order to study the coupling be- tween a fusion machine and a subcritical fission system. Monte-Carlo (MC) codes are very flexible and they have to be considered as refer- ence calculation tools for complex systems like FFHS. On the other hand, deterministic codes can provide, in shorter calculation time respect to MC codes, parametric and sensitivity analysis, also by exploiting General Perturbation Theory (GPT) methodologies, which can usefully support the global FFHS theoretical analysis. This work describes the comparison between the results obtained for a simplified FFHS model by using a MC code (MCNP6.1, MC N-Particle) and a deterministic code (ERANOS). In particular, in this preliminary study, integral pa- rameters like keff, thermal power, neutron fluxes and some key reaction rate profiles, will be compared. If the comparison between the two mentioned codes will give encouraging results further, more refined, studies will be performed in order to consider deterministic codes as a powerful workhorse for the FFHS analysis, including time dependent analysis devoted to transient and reactivity monitoring issues.

Published
2021
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41. Subcriticality monitoring in fusion-fission hybrid reactors

Author

E. Santoro, Enea Cr Bologna, V. Fabrizio, A. Gandini, N. Burgio, Enea Cre Casaccia, M.B. Sciarretta, Luca Falconi, R. Gatto, V. Peluso, M. Carta, Burgio, N., Carta, M., Fabrizio, V., Falconi, L., Gandini, A., Gatto, R., Peluso, V., Santoro, E., and Sciarretta, M. B.

Subjects
fusion-fission hybrid reactor, subcritical fission core, subcritical multiplication factor, reactivity monitoring, Nuclear and High Energy Physics, Fusion-fission hybrid reactor, Materials science, Reactivity monitoring, Nuclear Energy and Engineering, Subcritical fission core, Nuclear engineering, Fusion fission, Condensed Matter Physics, Subcritical multiplication factor
Abstract

Based on the heuristically generalized perturbation theory (HGPT) adapted to subcritical systems [1], a procedure for online operational monitoring of the subcriticality level of a hybrid fusion-fission system in which an “external” neutron source is generated in a magnetically confined tokamak-type plasma is described. This procedure [2], commonly referred to as power control-based subcriticality monitoring (PCSM), consists of compensating of slow and small movements of a specialized control rod in the nuclear fission zone, previously calibrated using a standard procedure, with equally slow and small alterations of the fusion neutron source. PCSM is verified by solving the multi-group transport equation for the direct flux, as well as for the importance function, associated with normalized fission power [3], and a technique is proposed for modifying the fusion neutron source strength based on plasma compression/expansion. Plasma and confining magnetic field adjustments, needed to implement the PCSM, are estimated with due account of the 0-D-plasma power balance.

Published
2021

42. An approach to the experimental validation of the fission multiplying blanket of hybrid fusion fission systems

Author

F. Orsitto, V. Fabrizio, Luca Falconi, M. Palomba, Mario Carta, F. Panza, N. Burgio, M. Salvatores, Salvatores, M., Orsitto, F., Carta, M., Burgio, N., Fabrizio, V., Falconi, L., Palomba, M., and Panza, F.

Subjects
Fusion fission hybrid systems, Nuclear transmutation, Fission, 020209 energy, Nuclear engineering, FFHS, Subcritical systems, Fusion fission, 02 engineering and technology, Experimental validation, Blanket, 01 natural sciences, 010305 fluids & plasmas, TRIGA reactors, Nuclear Energy and Engineering, Hybrid system, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Fission reactor
Abstract

Fusion Fission Hybrid Systems (FFHS) could have a potential role in the management of fission reactor wastes, with (in principle) some advantage over the comparable Accelerator Driven systems, devoted to the same objective. The validation of the concept poses major challenges in the area of fusion “source” development. However, the physics of the multiplying and transmutation blanket has also to be carefully understood and validated. Simple experiments can be envisaged for that purpose. Some of these experiments have already been performed in a different research framework (i.e. validation of the ADS concepts) and could constitute a very first database. Moreover, a new series of similar experiments could be planned.

Published
2021

43. Preliminary study of a closed loop vertical ground source heat pump system for an experimental pilot plant (Rome, Italy)

Author

Luca Falconi, Giambattista Guidi, Filippo Donato, Anna Carmela Violante, Marco Proposito, Violante, A. C., Proposito, M., Donato, F., Guidi, G., and Falconi, L. M.

Subjects
Primary energy, 020209 energy, Borehole, 02 engineering and technology, Civil engineering, law.invention, Vertical closed loop, law, 0202 electrical engineering, electronic engineering, information engineering, ASHRAE 90.1, Pilot plant design, Distributed temperature sensing (DTS) optical fibres, 0601 history and archaeology, 060102 archaeology, Renewable Energy, Sustainability and the Environment, business.industry, 06 humanities and the arts, Sizing, Pilot plant, Direct use, Environmental science, Electricity, business, Thermal energy, Ground source heat pump (GSHP), Heat pump
Abstract

A system for capturing thermal energy is planned for installation at the ENEA-Casaccia centre (Italy). Costs, primary energy requirements, pollutant emissions and seasonal electricity consumption were estimated. The configuration based on four boreholes of different depths and the sizing of the vertical loop (double-U) were performed according to the ASHRAE method. This pilot plant, the first under construction within an Italian research centre, is part of a long-term research project funded by the Italian Ministry of Economic Development. The results of this research could be applied throughout the Italian Tyrrhenian Apennine margin, which is geologically characterised by highly conductive lithotypes.

Published
2021

44. Radiation Tolerant 3D Laser Scanner for Structural Inspections in Nuclear Reactor Vessels and Fuel Storage Pools

Author

Massimiliano Guarneri, Fabio Pollastrone, Luca Falconi, Mario Carta, M. Francucci, Massimiliano Ciaffi, Marcello Nuvoli, Luigi De Dominicis, Mario Ferri De Collibus, De Dominicis, L., Carta, M., Ciaffi, M., Falconi, L., Ferri De Collibus, M., Francucci, M., Guarneri, M., Nuvoli, M., and Pollastrone, F.

Subjects
Article Subject, Laser scanning, 020209 energy, Nuclear engineering, Detector, Field of view, 02 engineering and technology, Nuclear reactor, 01 natural sciences, Spent nuclear fuel, 010305 fluids & plasmas, law.invention, TK1-9971, Nuclear Energy and Engineering, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Water cooling, Environmental science, Research reactor, Electrical engineering. Electronics. Nuclear engineering, Underwater
Abstract

Accurate and timely assessment of displacements and/or structural damages in nuclear reactor vessels’ components is a key action in routine inspections for planning maintenance and repairs but also in emergency situations for mitigating consequences of nuclear incidents. Nevertheless, all these components are maintained underwater and reside in high-radiation fields thus imposing harsh operative conditions to inspection devices which must cope with effects such as Cerenkov radiation background, Total Ionizing Radiation (TID), and occlusions in the detectors’ field of view. To date, ultrasonic techniques and video cameras are in use for inspection of components’ integrity and with measurements of volumetric and surface crack opening displacements, respectively. The present work reports the realization of a radiation tolerant laser scanner and the results of tests in a nuclear research reactor vessel for acquisition of 3D models of critical components. The device, qualified for underwater operation and for withstanding up to 1 MGy of TID, is based on a 515 nm laser diode and a fast-scanning electro-optic unit. To evaluate performances in a significant but controlled environment, the device has been deployed in the vessel of a research reactor operated by ENEA in the Casaccia Research Centre in Rome (Italy). A 3D model of the fuel rods assembly through a cooling water column of 7 m has been acquired. The system includes proprietary postprocessing software that automatically recognizes components of interest and provides dimensional analysis. Possible application fields of the system stretch to dimensional analysis also in spent nuclear fuel storage pools.

Published
2021

46. A user-friendly, digital console for the control room parameters supervision in old-generation nuclear plants

Author

Mario Palomba, Fabrizio Memmi, Massimo Sepielli, Luca Falconi, Mauro Cappelli, Sepielli, M., Palomba, M., Cappelli, M., and Falconi, L.

Subjects
Nuclear and High Energy Physics, Engineering, Decision support system, 020209 energy, Interface (computing), ComputerApplications_COMPUTERSINOTHERSYSTEMS, 02 engineering and technology, 01 natural sciences, 010305 fluids & plasmas, law.invention, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Process control, General Materials Science, Instrumentation (computer programming), Safety, Risk, Reliability and Quality, Waste Management and Disposal, Simulation, business.industry, Mechanical Engineering, Nuclear reactor, Nuclear power, Control room, Nuclear Energy and Engineering, Front panel, business
Abstract

In this work a user-friendly, digital monitoring system for supervision of process variables coming from a fission nuclear reactor of TRIGA type (1-MW TRIGA reactor RC-1) is presented. The system, developed on the basis of COTS tools, can easily interface the control room instrumentation and display the typical monitoring parameters (e.g. nuclear power, temperatures, flow rates, radiological variables) in an intuitive, user-adjustable way for plant operators. A front panel of a virtual instrument allows for a direct measure while the acquisition system, for signals coming from the reactor, can process the data and generate a detailed representation of the results, whose statistics can be interpreted to optimize the reactor management parameters. This system has been also designed so as to include a simulation tool able to predict specific performances and investigate critical phenomena, and to optimize overall plant performances. In particular, it allows to have a feedback control and to perform several predictive statistical surveys of all main process parameters. The proposed system could help operators in training and continuous learning activities, and serve as a basis for an advanced decision support system and for a remote training tool for students and trainees not authorized to work in a radiation environment. © 2016 Elsevier B.V. All rights reserved.

Published
2016
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48. The RUSLE erosion index as a proxy indicator for debris flow susceptibility

Author

Luca Falconi, C. Puglisi, Alessandro Zini, Sergio Grauso, Vladimiro Verrubbi, Gabriele Leoni, Puglisi, C., Leoni, G., Falconi, L., Verrubbi, V., Grauso, S., and Zini, A.

Subjects
Hydrology, Data collection, Susceptibility modeling, Logistic regression, Landslide, RUSLE, Debris flows, Soil erosion, Debris flow, Geotechnical Engineering and Engineering Geology, Debris, Universal Soil Loss Equation, Geography, Natural hazard, Erosion, Predictive modelling
Abstract

Debris flows represent dangerous occurrences in many parts of the world. Several disasters are documented due to this type of fast-moving landslides; therefore, natural-hazard assessment of debris flows is crucial for safety of life and property. To this aim, much current work is being directed toward developing geotechnical-hydraulic models for the evaluation of debris flow susceptibility. A common base for such current models is parameterization of background predisposing and triggering factors such as inherent characteristics of geo-materials, topography, landscape and vegetation cover, rainfall regime, human activities, etc. which influence the occurrence of these processes on slopes. The same factors are also taken into account in soil erosion prediction models. Consequently, it seems worth investigating the effectiveness of the soil erosion index as debris flows susceptibility indicator. To this aim, a logistic regression analysis was carried out between the erosion index assessed by means of the Revised Universal Soil Loss Equation (RUSLE) model and the inventory of debris flows that have occurred in an area in Sicily (Southern Italy). Model assumptions were verified and validated by means of a series of statistical tools. Different possible scenarios were also evaluated by considering hypothetical changes in soil erosion rate under different rain erosivity conditions. Notwithstanding the rough approximations in model data collection, the outcomes appear encouraging. © 2014, Springer-Verlag Berlin Heidelberg.

Published
2014
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49. The power control based subcriticality monitoring (PCSM) method fro ADS reactors

Author

M. Carta, V. Fabrizio, L. Falconi, A. Gandini, M. G. Iorio, V. Peluso, E Santoro, N. Burgio, M.Carta, V.Fabrizio, L.Falconi, A.Gandini, M.G.Iorio, V.Peluso, E,Santoro, N.Burgio, Eutopean Nuclear Society, Carta, M., Fabrizio, V., Falconi, L., Gandini, A., Iorio, M. G., Peluso, V., Santoro, E, and Burgio, N.

Published
2016

50. A MCNPX TRIGA RC1Eeperimental channels model for the design of a new neutronic diffraction facility

Author

L. Falconi, N. Burgio, M. Palomba, E. Santoro, M. Carta, M. Prata, A. Salvini, P. Ghigna, S. Altieri, S. Bortolussi, L. Reversi, L.Falconi, N.Burgio, M.Palomba, E.Santoro, M.Carta, M.Prata, A.Salvini, P.Ghigna, S.Altieri, S.Bortolussi, L.Reversi, European Nuclear Society, Falconi, L., Burgio, N., Palomba, M., Santoro, E., Carta, M., Prata, M., Salvini, A., Ghigna, P., Altieri, S., Bortolussi, S., and Reversi, L.

Published
2016

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