1,725 results on '"Falck, John R."'
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2. Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats
3. Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis.
4. Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension
5. Cardioprotective Action of a Novel Synthetic 19,20-EDP Analog Is Sirt Dependent
6. Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1
7. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization
8. Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A2A receptor and plasma oxylipins
9. Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice
10. Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases
11. Activation of GPR75 Signaling Pathway Contributes to the Effect of a 20-HETE Mimetic, 5,14-HEDGE, to Prevent Hypotensive and Tachycardic Responses to Lipopolysaccharide in a Rat Model of Septic Shock
12. Macrophage 12(S)-HETE Enhances Angiotensin II–Induced Contraction by a BLT2 (Leukotriene B4 Type-2 Receptor) and TP (Thromboxane Receptor)-Mediated Mechanism in Murine Arteries
13. Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation
14. Epoxyeicosanoids promote organ and tissue regeneration
15. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
16. Phosphoinositide 3-Kinase Activates Rac by Entering in a Complex with Eps8, Abi1, and Sos-1
17. Alterations in the Regulation of Androgen-Sensitive Cyp 4a Monooxygenases Cause Hypertension
18. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats
19. Phospholipase A 2 -mediated Activation of Mitogen-Activated Protein Kinase by Angiotensin II
20. Supplementary Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production
21. Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production
22. Supplementary Figure 3 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
23. Supplementary Figure Legend from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
24. Data from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
25. Supplementary Figure 1 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
26. Supplementary Figure 2 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
27. Effect of Chronically Suppressed Plasma Angiotensin II on Regulation of the CYP4A/20-HETE Pathway in the Dahl Salt-Sensitive Rat
28. 20-HETE/GPR75 pairing modulates the expression and transcriptional activity of the androgen receptor in androgen-sensitive prostate cancer cells
29. Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen–Glucose Deprivation in Cortical Neurons
30. 20-HETE contributes to ischemia-induced angiogenesis
31. Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats’ Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids
32. Dirhodium-catalyzed C-H arene amination using hydroxylamines
33. Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats
34. 20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis
35. Directed, Remote Dirhodium C(sp3)-H Functionalization, Desaturative Annulation, and Desaturation
36. Effect of Angiotensin II and ACTH on Adrenal Blood Flow in the Male Rat Adrenal Gland In Vivo
37. Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins
38. Abstract 16580: A Novel Synthetic Omega-3 Epoxyeicosanoid Analogue Mediates Cardioprotection by Modulating Mitochondrial Function
39. Abstract 16481: A Novel Synthetic Omega-3 Epoxyeicosanoid Analogue Modulates Ca2+ Handling and Exerts Anti-Arrhythmic Effects
40. Orally Active Epoxyeicosatrienoic Acid Analogs
41. Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock
42. Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids
43. Role of Substrates and Products of PI 3-Kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav
44. Abstract LB564: (±) 14,15-epoxyeicosatrienoic acid induces hallmark ER and MYC gene expression and associated ER and c-Myc nuclear translocation in ER+/HER2- breast cancer cells
45. Structure‐Function Relationship of the 20‐HETE‐GPR75 pairing: Development and characterization of agonist, partial agonists, and receptor blockers
46. Development of Enzyme Immunoassays for 5,6-, 8,9-,11,12-, And 14,15- Eets and the Corresponding Dhets
47. Blockade of 20-HETE Receptor Lowers Blood Pressure and Alters Vascular Function in Mice with Smooth Muscle-Specific Overexpression of CYP4A12-20-HETE Synthase
48. 11,12 -Epoxyeicosatrienoic acid (11,12 EET) reduces excitability and excitatory transmission in the hippocampus
49. Rhodium catalyzed synthesis of isoindolinones via C–H activation of N-benzoylsulfonamides
50. Protection by 20-5,14-HEDGE Against Surgically Induced Ischemia Reperfusion Lung Injury in Rats
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