693 results on '"Fairlamb, Alan H."'
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2. Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1.
3. Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
4. Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties
5. Validation of Trypanosoma cruzi inactivation techniques for laboratory use.
6. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi
7. Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
8. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
9. A novel multiple-stage antimalarial agent that inhibits protein synthesis
10. Melarsoprol Resistance in African Trypanosomiasis
11. The Genome of the African Trypanosome Trypanosoma brucei
12. A Trypanothione-Dependent Glyoxalase I with a Prokaryotic Ancestry in Leishmania major
13. The critical role of mode of action studies in kinetoplastid drug discovery
14. Metabolic Pathway Analysis in Trypanosomes and Malaria Parasites
15. Down-Regulation of Leishmania donovani Trypanothione Reductase by Heterologous Expression of a Trans-Dominant Mutant Homologue: Effect on Parasite Intracellular Survival
16. Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
17. Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity
18. Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
19. Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis
20. Quinol derivatives as potential trypanocidal agents
21. Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
22. Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes
23. Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei
24. Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
25. Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases
26. Surmounting structural barriers to tackle endemic infectious diseases
27. Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity
28. 8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase
29. Drug resistance in eukaryotic microorganisms
30. TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei
31. Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei
32. Chloroquine Resistance Is Not Associated with Drug Metabolism in Plasmodium falciparum
33. ``Subversive'' Substrates for the Enzyme Trypanothione Disulfide Reductase: Alternative Approach to Chemotherapy of Chagas Disease
34. Trypanothione is the Primary Target for Arsenical Drugs against African Trypanosomes
35. Isolation and Characterization of Kinetoplast DNA from Bloodstream Form of Trypanosoma brucei
36. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
37. Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy
38. Target assessment for antiparasitic drug discovery
39. Characterisation of a putative glutamate 5‐kinase from Leishmania donovani
40. Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome
41. Time-dependent inhibitors of trypanothione reductase: Analogues of the spermidine alkaloid lunarine and related natural products
42. Genome sequence of the human malaria parasite Plasmodium falciparum
43. Infectious disease: Genomics decodes drug action: Drugs used to treat African sleeping sickness are outdated, and how they enter cells and exert biological effects is poorly understood. A genome-wide study using RNA interference provides valuable insight. See Letter p.232
44. Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
45. New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi
46. The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani
47. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis
48. Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice
49. Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis
50. A study of glycerophosphate oxidase in Trypanosoma brucei
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