273 results on '"Fair, Joseph"'
Search Results
2. Correction: Correction: A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa.
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Grard, Gilda, Fair, Joseph N, Lee, Deanna, Slikas, Elizabeth, Steffen, Imke, Muyembe, Jean-Jacques, Sittler, Taylor, Veeraraghavan, Narayanan, Ruby, J Graham, Wang, Chunlin, Makuwa, Maria, Mulembakani, Prime, Tesh, Robert B, Mazet, Jonna, Rimoin, Anne W, Taylor, Travis, Schneider, Bradley S, Simmons, Graham, Delwart, Eric, Wolfe, Nathan D, Chiu, Charles Y, and Leroy, Eric M
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Virology ,Microbiology ,Immunology ,Medical Microbiology - Abstract
[This corrects the article DOI: 10.1371/journal.ppat.1002924.].
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- 2017
3. Viral Forecasting, Pathogen Cataloging, and Disease Ecosystem Mapping: Measuring Returns on Investments
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Fair, Jeanne, Fair, Joseph, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W, Series Editor, Galan, Jorge E, Series Editor, Garcia-Sastre, Adolfo, Series Editor, Malissen, Bernard, Series Editor, Rappuoli, Rino, Series Editor, Inglesby, Thomas V., editor, and Adalja, Amesh A., editor
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- 2019
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4. A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples
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Naccache, Samia N, Federman, Scot, Veeraraghavan, Narayanan, Zaharia, Matei, Lee, Deanna, Samayoa, Erik, Bouquet, Jerome, Greninger, Alexander L, Luk, Ka-Cheung, Enge, Barryett, Wadford, Debra A, Messenger, Sharon L, Genrich, Gillian L, Pellegrino, Kristen, Grard, Gilda, Leroy, Eric, Schneider, Bradley S, Fair, Joseph N, Martínez, Miguel A, Isa, Pavel, Crump, John A, DeRisi, Joseph L, Sittler, Taylor, Hackett, John, Miller, Steve, and Chiu, Charles Y
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Microbiology ,Biological Sciences ,Bioinformatics and Computational Biology ,Bioengineering ,Prevention ,Vaccine Related ,Human Genome ,Biodefense ,Infectious Diseases ,Genetics ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Infection ,Good Health and Well Being ,Computational Biology ,Databases ,Nucleic Acid ,High-Throughput Nucleotide Sequencing ,Humans ,Metagenomics ,ROC Curve ,Reproducibility of Results ,Software ,Medical and Health Sciences ,Bioinformatics - Abstract
Unbiased next-generation sequencing (NGS) approaches enable comprehensive pathogen detection in the clinical microbiology laboratory and have numerous applications for public health surveillance, outbreak investigation, and the diagnosis of infectious diseases. However, practical deployment of the technology is hindered by the bioinformatics challenge of analyzing results accurately and in a clinically relevant timeframe. Here we describe SURPI ("sequence-based ultrarapid pathogen identification"), a computational pipeline for pathogen identification from complex metagenomic NGS data generated from clinical samples, and demonstrate use of the pipeline in the analysis of 237 clinical samples comprising more than 1.1 billion sequences. Deployable on both cloud-based and standalone servers, SURPI leverages two state-of-the-art aligners for accelerated analyses, SNAP and RAPSearch, which are as accurate as existing bioinformatics tools but orders of magnitude faster in performance. In fast mode, SURPI detects viruses and bacteria by scanning data sets of 7-500 million reads in 11 min to 5 h, while in comprehensive mode, all known microorganisms are identified, followed by de novo assembly and protein homology searches for divergent viruses in 50 min to 16 h. SURPI has also directly contributed to real-time microbial diagnosis in acutely ill patients, underscoring its potential key role in the development of unbiased NGS-based clinical assays in infectious diseases that demand rapid turnaround times.
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- 2014
5. Genomic Variability of Monkeypox Virus among Humans, Democratic Republic of the Congo - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC
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Kugelman, Jeffrey R, Johnston, Sara C, Mulembakani, Prime M, Kisalu, Neville, Lee, Michael S, Koroleva, Galina, McCarthy, Sarah E, Gestole, Marie C, Wolfe, Nathan D, Fair, Joseph N, Schneider, Bradley S, Wright, Linda L, Huggins, John, Whitehouse, Chris A, Wemakoy, Emile Okitolonda, Muyembe-Tamfum, Jean Jacques, Hensley, Lisa E, Palacios, Gustavo F, and Rimoin, Anne W
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Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Biodefense ,Human Genome ,Infectious Diseases ,Clinical Research ,Vaccine Related ,Prevention ,Rare Diseases ,Emerging Infectious Diseases ,Genetics ,2.4 Surveillance and distribution ,Aetiology ,2.2 Factors relating to the physical environment ,Infection ,Good Health and Well Being ,Adaptation ,Biological ,Amino Acid Sequence ,Animals ,Democratic Republic of the Congo ,Epidemiological Monitoring ,Gene Deletion ,Genome ,Viral ,Genomic Instability ,Humans ,Molecular Sequence Data ,Monkeypox ,Monkeypox virus ,Phylogeny ,Sequence Analysis ,DNA ,Severity of Illness Index ,emerging infectious disease ,gene loss ,genomic diversity ,genomic reduction ,viruses ,Public Health and Health Services ,Microbiology ,Clinical sciences ,Epidemiology ,Health services and systems - Abstract
Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking. We therefore assessed genome diversity of viruses in 60 samples obtained from humans with primary and secondary cases of infection from 2005 through 2007. We detected 4 distinct lineages and a deletion that resulted in gene loss in 10 (16.7%) samples and that seemed to correlate with human-to-human transmission (p = 0.0544). The data suggest a high frequency of spillover events from the pool of viruses in nonhuman animals, active selection through genomic destabilization and gene loss, and increased disease transmissibility and severity. The potential for accelerated adaptation to humans should be monitored through improved surveillance.
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- 2014
6. Akelaitis, Andrew John Edward ('A.J.') (1904–1955)
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Larson, Michael J., Fair, Joseph E., Kreutzer, Jeffrey S., editor, DeLuca, John, editor, and Caplan, Bruce, editor
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- 2018
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7. Characterization of the Bas-Congo Virus Glycoprotein and Its Function in Pseudotyped Viruses
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Steffen, Imke, Liss, Nathan M, Schneider, Bradley S, Fair, Joseph N, Chiu, Charles Y, and Simmons, Graham
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Biochemistry and Cell Biology ,Medical Microbiology ,Biomedical and Clinical Sciences ,Biological Sciences ,Biodefense ,Emerging Infectious Diseases ,Prevention ,Vaccine Related ,Infectious Diseases ,2.2 Factors relating to the physical environment ,Aetiology ,Infection ,Good Health and Well Being ,Amino Acid Sequence ,Animals ,Cell Line ,Congo ,Cricetinae ,Humans ,Membrane Fusion ,Membrane Glycoproteins ,Mice ,Molecular Sequence Data ,Rhabdoviridae ,Rhabdoviridae Infections ,Sequence Homology ,Amino Acid ,Viral Envelope Proteins ,Virus Internalization ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Virology ,Agricultural ,veterinary and food sciences ,Biological sciences ,Biomedical and clinical sciences - Abstract
Bas-Congo virus (BASV) is a novel rhabdovirus recently identified from a patient with acute hemorrhagic fever in the Bas-Congo province of the Democratic Republic of Congo (DRC). Here we show that the BASV glycoprotein (BASV-G) can be successfully used to pseudotype glycoprotein-deficient vesicular stomatitis virus (VSV), allowing studies of BASV-G-driven membrane fusion and viral entry into target cells without replication-competent virus. BASV-G displayed broad tissue and species tropism in vitro, and BASV-G-mediated membrane fusion was pH dependent. The conformational changes induced in BASV-G by acidification were fully reversible and did not lead to inactivation of the viral fusion protein. Our data combined with comparative sequence similarity analyses suggest that BASV-G shares structural and functional features with other rhabdovirus glycoproteins and falls into the group of class III viral fusion proteins. However, activation of BASV-G-driven fusion required a lower pH and higher temperatures than did VSV-G-mediated fusion. Moreover, in contrast to VSV-G, mature BASV-G in VSV pseudotypes consists of a mixture of high-mannose and complex glycans that enables it to bind to certain C-type lectins, thereby enhancing its attachment to target cells. Taken together, the results presented in this study will facilitate future investigations of BASV-G-mediated cell entry and its inhibition in the absence of an infectious cell culture assay for BASV and at lower biosafety levels. Moreover, serology testing based on BASV-G pseudotype neutralization can be used to uncover the prevalence and importance of BASV as a potential novel human pathogen in the DRC and throughout Central Africa.
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- 2013
8. Pathogen-host associations and predicted range shifts of human monkeypox in response to climate change in central Africa.
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Thomassen, Henri A, Fuller, Trevon, Asefi-Najafabady, Salvi, Shiplacoff, Julia AG, Mulembakani, Prime M, Blumberg, Seth, Johnston, Sara C, Kisalu, Neville K, Kinkela, Timothée L, Fair, Joseph N, Wolfe, Nathan D, Shongo, Robert L, LeBreton, Matthew, Meyer, Hermann, Wright, Linda L, Muyembe, Jean-Jacques, Buermann, Wolfgang, Okitolonda, Emile, Hensley, Lisa E, Lloyd-Smith, James O, Smith, Thomas B, and Rimoin, Anne W
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Animals ,Cercopithecus ,Humans ,Sciuridae ,Monkeypox virus ,Trees ,Monkeypox ,Ecosystem ,Disease Reservoirs ,Geography ,Models ,Theoretical ,Democratic Republic of the Congo ,Host-Pathogen Interactions ,Climate Change ,General Science & Technology - Abstract
Climate change is predicted to result in changes in the geographic ranges and local prevalence of infectious diseases, either through direct effects on the pathogen, or indirectly through range shifts in vector and reservoir species. To better understand the occurrence of monkeypox virus (MPXV), an emerging Orthopoxvirus in humans, under contemporary and future climate conditions, we used ecological niche modeling techniques in conjunction with climate and remote-sensing variables. We first created spatially explicit probability distributions of its candidate reservoir species in Africa's Congo Basin. Reservoir species distributions were subsequently used to model current and projected future distributions of human monkeypox (MPX). Results indicate that forest clearing and climate are significant driving factors of the transmission of MPX from wildlife to humans under current climate conditions. Models under contemporary climate conditions performed well, as indicated by high values for the area under the receiver operator curve (AUC), and tests on spatially randomly and non-randomly omitted test data. Future projections were made on IPCC 4(th) Assessment climate change scenarios for 2050 and 2080, ranging from more conservative to more aggressive, and representing the potential variation within which range shifts can be expected to occur. Future projections showed range shifts into regions where MPX has not been recorded previously. Increased suitability for MPX was predicted in eastern Democratic Republic of Congo. Models developed here are useful for identifying areas where environmental conditions may become more suitable for human MPX; targeting candidate reservoir species for future screening efforts; and prioritizing regions for future MPX surveillance efforts.
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- 2013
9. DNA of diverse adenoviruses detected in Cameroonian rodent and shrew species
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Diffo, Joseph, Ndze, Valantine Ngum, Ntumvi, Nkom Felix, Takuo, Jean-Michel, Mouiche, Moctar M. M., Tamoufe, Ubald, Nwobegahay, Julius, LeBreton, Matthew, Gillis, Amethyst, Schneider, Bradley S., Fair, Joseph M., Monagin, Corina, McIver, David J., Joly, Damien O., Wolfe, Nathan D., Rubin, Edward M., and Lange, Christian E.
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- 2019
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10. A novel rhabdovirus associated with acute hemorrhagic fever in central Africa.
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Grard, Gilda, Fair, Joseph N, Lee, Deanna, Slikas, Elizabeth, Steffen, Imke, Muyembe, Jean-Jacques, Sittler, Taylor, Veeraraghavan, Narayanan, Ruby, J Graham, Wang, Chunlin, Makuwa, Maria, Mulembakani, Prime, Tesh, Robert B, Mazet, Jonna, Rimoin, Anne W, Taylor, Travis, Schneider, Bradley S, Simmons, Graham, Delwart, Eric, Wolfe, Nathan D, Chiu, Charles Y, and Leroy, Eric M
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Animals ,Humans ,Mice ,Rhabdoviridae ,Hemorrhagic Fevers ,Viral ,Rhabdoviridae Infections ,Antibodies ,Viral ,Disease Outbreaks ,Phylogeny ,Genome ,Viral ,Molecular Sequence Data ,Adolescent ,Adult ,Democratic Republic of the Congo ,Female ,Male ,High-Throughput Nucleotide Sequencing ,Hemorrhagic Fevers ,Viral ,Antibodies ,Genome ,Virology ,Microbiology ,Immunology ,Medical Microbiology - Abstract
Deep sequencing was used to discover a novel rhabdovirus (Bas-Congo virus, or BASV) associated with a 2009 outbreak of 3 human cases of acute hemorrhagic fever in Mangala village, Democratic Republic of Congo (DRC), Africa. The cases, presenting over a 3-week period, were characterized by abrupt disease onset, high fever, mucosal hemorrhage, and, in two patients, death within 3 days. BASV was detected in an acute serum sample from the lone survivor at a concentration of 1.09 × 10(6) RNA copies/mL, and 98.2% of the genome was subsequently de novo assembled from ≈ 140 million sequence reads. Phylogenetic analysis revealed that BASV is highly divergent and shares less than 34% amino acid identity with any other rhabdovirus. High convalescent neutralizing antibody titers of >1:1000 were detected in the survivor and an asymptomatic nurse directly caring for him, both of whom were health care workers, suggesting the potential for human-to-human transmission of BASV. The natural animal reservoir host or arthropod vector and precise mode of transmission for the virus remain unclear. BASV is an emerging human pathogen associated with acute hemorrhagic fever in Africa.
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- 2012
11. Using Remote Sensing to Map the Risk of Human Monkeypox Virus in the Congo Basin
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Fuller, Trevon, Thomassen, Henri A, Mulembakani, Prime M, Johnston, Sara C, Lloyd-Smith, James O, Kisalu, Neville K, Lutete, Timothee K, Blumberg, Seth, Fair, Joseph N, Wolfe, Nathan D, Shongo, Robert L, Formenty, Pierre, Meyer, Hermann, Wright, Linda L, Muyembe, Jean-Jacques, Buermann, Wolfgang, Saatchi, Sassan S, Okitolonda, Emile, Hensley, Lisa, Smith, Thomas B, and Rimoin, Anne W
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Veterinary Sciences ,Agricultural ,Veterinary and Food Sciences ,Biological Sciences ,Ecology ,Biodefense ,Emerging Infectious Diseases ,Prevention ,Vaccine Related ,Animals ,Democratic Republic of the Congo ,Disease Reservoirs ,Disease Vectors ,Humans ,Monkeypox ,Monkeypox virus ,Population Surveillance ,Regression Analysis ,Remote Sensing Technology ,Risk Assessment ,Sciuridae ,Trees ,monkeypox ,orthopoxvirus ,smallpox vaccination ,epidemiology ,active surveillance ,human transmission ,Public Health and Health Services ,Veterinary sciences - Abstract
Although the incidence of human monkeypox has greatly increased in Central Africa over the last decade, resources for surveillance remain extremely limited. We conducted a geospatial analysis using existing data to better inform future surveillance efforts. Using active surveillance data collected between 2005 and 2007, we identified locations in Sankuru district, Democratic Republic of Congo (DRC) where there have been one or more cases of human monkeypox. To assess what taxa constitute the main reservoirs of monkeypox, we tested whether human cases were associated with (i) rope squirrels (Funisciurus sp.), which were implicated in monkeypox outbreaks elsewhere in the DRC in the 1980s, or (ii) terrestrial rodents in the genera Cricetomys and Graphiurus, which are believed to be monkeypox reservoirs in West Africa. Results suggest that the best predictors of human monkeypox cases are proximity to dense forests and associated habitat preferred by rope squirrels. The risk of contracting monkeypox is significantly greater near sites predicted to be habitable for squirrels (OR = 1.32; 95% CI 1.08-1.63). We recommend that semi-deciduous rainforests with oil-palm, the rope squirrel's main food source, be prioritized for monitoring.
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- 2011
12. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo
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Rimoin, Anne W, Mulembakani, Prime M, Johnston, Sara C, Lloyd Smith, James O, Kisalu, Neville K, Kinkela, Timothee L, Blumberg, Seth, Thomassen, Henri A, Pike, Brian L, Fair, Joseph N, Wolfe, Nathan D, Shongo, Robert L, Graham, Barney S, Formenty, Pierre, Okitolonda, Emile, Hensley, Lisa E, Meyer, Hermann, Wright, Linda L, and Muyembe, Jean-Jacques
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Emerging Infectious Diseases ,Biodefense ,Rare Diseases ,Vaccine Related ,Infectious Diseases ,Small Pox ,Prevention ,Immunization ,Infection ,Good Health and Well Being ,Adolescent ,Adult ,Age Distribution ,Child ,Child ,Preschool ,Climate ,Democratic Republic of the Congo ,Female ,Humans ,Infant ,Male ,Monkeypox ,Rural Health ,Smallpox ,Smallpox Vaccine ,Time Factors ,Young Adult ,active surveillance ,orthopoxvirus ,zoonosis ,eradication - Abstract
Studies on the burden of human monkeypox in the Democratic Republic of the Congo (DRC) were last conducted from 1981 to 1986. Since then, the population that is immunologically naïve to orthopoxviruses has increased significantly due to cessation of mass smallpox vaccination campaigns. To assess the current risk of infection, we analyzed human monkeypox incidence trends in a monkeypox-enzootic region. Active, population-based surveillance was conducted in nine health zones in central DRC. Epidemiologic data and biological samples were obtained from suspected cases. Cumulative incidence (per 10,000 population) and major determinants of infection were compared with data from active surveillance in similar regions from 1981 to 1986. Between November 2005 and November 2007, 760 laboratory-confirmed human monkeypox cases were identified in participating health zones. The average annual cumulative incidence across zones was 5.53 per 10,000 (2.18-14.42). Factors associated with increased risk of infection included: living in forested areas, male gender, age < 15, and no prior smallpox vaccination. Vaccinated persons had a 5.2-fold lower risk of monkeypox than unvaccinated persons (0.78 vs. 4.05 per 10,000). Comparison of active surveillance data in the same health zone from the 1980s (0.72 per 10,000) and 2006-07 (14.42 per 10,000) suggests a 20-fold increase in human monkeypox incidence. Thirty years after mass smallpox vaccination campaigns ceased, human monkeypox incidence has dramatically increased in rural DRC. Improved surveillance and epidemiological analysis is needed to better assess the public health burden and develop strategies for reducing the risk of wider spread of infection.
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- 2010
13. The Origin and Prevention of Pandemics
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Hughes, James M, Wilson, Mary E, Pike, Brian L, Saylors, Karen E, Fair, Joseph N, LeBreton, Matthew, Tamoufe, Ubald, Djoko, Cyrille F, Rimoin, Anne W, and Wolfe, Nathan D
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Stem Cell Research ,Prevention ,Behavioral and Social Science ,Infection ,Good Health and Well Being ,Animals ,Communicable Diseases ,Disease Outbreaks ,Disease Vectors ,Humans ,Zoonoses ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
Despite the fact that most emerging diseases stem from the transmission of pathogenic agents from animals to humans, the factors that mediate this process are still ill defined. What is known, however, is that the interface between humans and animals is of paramount importance in the process. This review will discuss the importance of the human-animal interface to the disease emergence process. We also provide an overview of factors that are believed to contribute to the origin and global spread of emerging infectious diseases and offer suggestions that may serve as future prevention strategies, such as social mobilization, public health education, behavioral change, and communication strategies. Because there exists no comprehensive global surveillance system to monitor zoonotic disease emergence, the intervention measures discussed herein may prove effective temporary alternatives.
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- 2010
14. The origin and prevention of pandemics.
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Pike, Brian L, Saylors, Karen E, Fair, Joseph N, Lebreton, Matthew, Tamoufe, Ubald, Djoko, Cyrille F, Rimoin, Anne W, and Wolfe, Nathan D
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Animals ,Humans ,Communicable Diseases ,Zoonoses ,Disease Outbreaks ,Disease Vectors ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
Despite the fact that most emerging diseases stem from the transmission of pathogenic agents from animals to humans, the factors that mediate this process are still ill defined. What is known, however, is that the interface between humans and animals is of paramount importance in the process. This review will discuss the importance of the human-animal interface to the disease emergence process. We also provide an overview of factors that are believed to contribute to the origin and global spread of emerging infectious diseases and offer suggestions that may serve as future prevention strategies, such as social mobilization, public health education, behavioral change, and communication strategies. Because there exists no comprehensive global surveillance system to monitor zoonotic disease emergence, the intervention measures discussed herein may prove effective temporary alternatives.
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- 2010
15. Day-of-Injury Computed Tomography and Longitudinal Rehabilitation Outcomes: A Comparison of the Marshall and Rotterdam Computed Tomography Scoring Methods
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Frodsham, Kayla M., Fair, Joseph E., Frost, R. Brock, Hopkins, Ramona O., Bigler, Erin D., Majercik, Sarah, Bledsoe, Joseph, Ryser, David, MacDonald, Joel, Barrett, Ryan, Horn, Susan D., Pisani, David, Stevens, Mark, and Larson, Michael J.
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- 2020
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16. Human Monkeypox in Sierra Leone after 44-Year Absence of Reported Cases
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Reynolds, Mary G., Wauquier, Nadia, Li, Yu, Satheshkumar, Panayampalli Subbian, Kanneh, Lansana D., Monroe, Benjamin, Maikere, Jacob, Saffa, Gbessay, Gonzalez, Jean-Paul, Fair, Joseph, Carroll, Darin S., Jambai, Amara, Dafae, Foday, Khan, Sheik Humarr, and Moses, Lina M.
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United States. Centers for Disease Control and Prevention -- Surveys ,Human monkeypox -- Surveys ,Lassa fever -- Surveys ,Zoonoses -- Surveys ,Health - Abstract
Monkeypox, a tropical zoonosis with an estimated death rate of 15% in children, is a resurgent presence in several countries in West and Central Africa (1,2). Before 2000, only 21 [...]
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- 2019
17. Akelaitis, Andrew John Edward (“A.J.”) (1904–1955)
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Larson, Michael J., primary and Fair, Joseph E., additional
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- 2017
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18. Perceptual Learning: 12-Month-Olds' Discrimination of Monkey Faces
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Fair, Joseph, Flom, Ross, and Jones, Jacob
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Six-month-olds reliably discriminate different monkey and human faces whereas 9-month-olds only discriminate different human faces. It is often falsely assumed that perceptual narrowing reflects a permanent change in perceptual abilities. In 3 experiments, ninety-six 12-month-olds' discrimination of unfamiliar monkey faces was examined. Following 20 s of familiarization, and two 5-s visual-paired comparison test trials, 12-month-olds failed to show discrimination. However, following 40 s of familiarization and two 10-s test trials, 12-month-olds showed reliable discrimination of novel monkey faces. A final experiment was performed demonstrating 12-month-olds' discrimination of the monkey face was due to the increased familiarization rather than increased time of visual comparison. Results are discussed in the context of perceptual narrowing, in particular the flexible nature of perceptual narrowing. (Contains 2 tables and 1 figure.)
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- 2012
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19. Akelaitis, Andrew John Edward ('A.J.') (1904–1955)
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Larson, Michael J., Fair, Joseph E., Kreutzer, Jeffrey S., editor, DeLuca, John, editor, and Caplan, Bruce, editor
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- 2011
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20. Supplement to: Molecular evidence of sexual transmission of Ebola virus.
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Mate, Suzanne E., Kugelman, Jeffrey R., Nyenswah, Tolbert G., Ladner, Jason T., Wiley, Michael R., Cordier-Lassalle, Thierry, Christie, Athalia, Schroth, Gary P., Gross, Stephen M., Davies-Wayne, Gloria J., Shinde, Shivam A., Murugan, Ratnesh, Sieh, Sonpon B., Badio, Moses, Fakoli, Lawrence, Taweh, Fahn, de Wit, Emmie, van Doremalen, Neeltje, Munster, Vincent J., Pettitt, James, Prieto, Karla, Humrighouse, Ben W., Ströher, Ute, DiClaro, Joseph W., Hensley, Lisa E., Schoepp, Randal J., Safronetz, David, Fair, Joseph, Kuhn, Jens H., Blackley, David J., Laney, Scott A., Williams, Desmond E., Lo, Terrence, Gasasira, Alex, Nichol, Stuart T., Formenty, Pierre, Kateh, Francis N., De Cock, Kevin M., Bolay, Fatorma, Sanchez-Lockhart, Mariano, and Palacios, Gustavo
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- 2015
21. Volumetric analysis of day of injury computed tomography is associated with rehabilitation outcomes after traumatic brain injury
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Majercik, Sarah, Bledsoe, Joseph, Ryser, David, Hopkins, Ramona O., Fair, Joseph E., Brock Frost, R., MacDonald, Joel, Barrett, Ryan, Horn, Susan, Pisani, David, Bigler, Erin D., Gardner, Scott, Stevens, Mark, and Larson, Michael J.
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- 2017
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22. Monitoring of Ebola virus Makona evolution through establishment of advanced genomic capability in Liberia
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Kugelman, Jeffrey R., Wiley, Michael R., Mate, Suzanne, Ladner, Jason T., Beitzel, Brett, Fakoli, Lawrence, Taweh, Fahn, Prieto, Karla, Diclaro, Joseph W., Minogue, Timothy, Schoepp, Randal J., Schaecher, Kurt E., Pettitt, James, Bateman, Stacey, Fair, Joseph, Kuhn, Jens H., Hensley, Lisa, Park, Daniel J., Sabeti, Pardis C., Sanchez-Lockhart, Mariano, Bolay, Fatorma K., and Palacios, Gustavo
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United States. Army. Medical Research Institute of Infectious Diseases ,Health ,World Health Organization - Abstract
The outbreak of Ebola virus disease (EVD) in Western Africa that started in November 2013 (1) is the largest recorded filovirus disease outbreak. As the outbreak continues, public health and [...]
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- 2015
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23. Emergence of Divergent Zaire Ebola Virus Strains in Democratic Republic of the Congo in 2007 and 2008
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Grard, Gilda, Biek, Roman, Tamfum, Jean-Jacques Muyembe, Fair, Joseph, Wolfe, Nathan, Formenty, Pierre, Paweska, Janusz, and Leroy, Eric
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- 2011
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24. Predictors of performance monitoring abilities following traumatic brain injury: The influence of negative affect and cognitive sequelae
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Larson, Michael J., Fair, Joseph E., Farrer, Thomas J., and Perlstein, William M.
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- 2011
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25. Undiagnosed acute viral febrile illnesses, Sierra Leone
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Schoepp, Randal J., Rossi, Cynthia A., Khan, Sheik H., Goba, Augustine, and Fair, Joseph N.
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Medical geography -- Research ,Medical case management -- Evaluation ,Virus diseases -- Care and treatment ,Health - Abstract
The West African country of Sierra Leone is located in a Lassa fever-hyperendemic region that also includes Guinea and Liberia. The causative agent of Lassa fever is Lassa virus (LASV), [...]
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- 2014
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26. List of contributors
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Abate, Ebba, Addiss, David, Agogo, Emmanuel, Agyarko, Robert, Al Slail, Fatima, Al-Nsour, Mohannad, Alemu, Wondimagegnehu, Alhusseini, Noara, Amir, Afreenish, Ammari, Duaa Al, André, Marcos R., Anyanwu, Lawrence N., Ardalan, Ali, Ario, Alex Riolexus, Asghar, Rana Jawad, Awoniyi, Oluwafunbi, Ayodele, James O., Babin, Francois-Xavier, Baer, Caroline, Bashir, Adnan, Barros Sierra Cordera, David, Belay, Ermias, Berrian, Amanda M., Bierer, Barbara E., Binkley, Laura E., Bisesi, Michael, Boussieres, Emmanuelle, Bower, William A., Brand, Bill, Brown, Garrett Wallace, Calderon, Ericka, Cardenas, Vicky, Choplin, Parker, Choupe, Luc Bertrand Tsachoua, Chunduru, Yashwant, Chungong, Stella, Cognat, Sebastien, Crawley, Francis P., Cuyvers, Jacqueline, de la Rocque, Stephane, DeTora, Lisa M., Dibaba, Legesse, Divi, Nomita, Dixon, Brian E., Djoudalbaye, Benjamin, Downey, Erin L., Ekmekci, Perihan Elif, England, Eliot, Erondu, Ngozi, Errecaborde, Kaylee, Fair, Joseph N., Fang, Jarjieh, Faulkner, Grace, Garrett, Denise O., Gebelin, Juliane, Gebreyes, Wondwossen A., Gentry, Brittany, Gillespie, Thomas R., Goldstone, Kara, Gomez Dantes, Hector, Gresham, Louise, Grooters, Susan Vaughn, Habte, Dereje, Haji Said, Ahmed, Haley, Carol J., Hernández Ávila, Mauricio, Ho, Marc, Hoet, Armando E., Holsted, Erin, Huda, Qudsia, Iamsirithaworn, Sopon, Ikram, Aamer, Jauregui, Barbara, Jitpeera, Charuttaporn, Kandel, Nirmal, Kebede, Senait, Kekeisen-Chen, Joann, Kimball, Ann Marie, Kingsley, Thomas, Kniel, Kalmia, Kromberg Underwood, Marika L., Larson, Heidi J., Lee, Jiyoung, LeJeune, Jeffrey T., Lin, Leesa, Liyanaarachchige, Neranga, Mabula, Peter S., Macfarlane, Sarah B., Magowe, Mabel K.M., Mala, Peter, Manrique-Saide, Pablo C., Mayet, Natalie, Mazet, Jonna A.K., McNabb, Scott J.N., Mekuria, Zelalem, Molkenthin, Allegra, Morales, Marissa, Moussif, Mohamed, Mukumbang, Ferdinand, Muñoz-Leal, Sebastián, Murray, Brittany L., Muyyarikkandy, Muhammed S., Negrón, María E., Nomura, Shuhei, Oh, Hanvit, Ohuabunwo, Chima J., Okereke, Ebere, Olatinwo, Saheedat, Omaar, Abbas, Owusu Agyare, Bernard, Oyebanji, Oyeronke, Passanante, Aly, Patel, Krishna, Paterson, Pauline, Perrone, Lucy A., Pertwee, Ed, Pesapane, Risa, Pollack, Marjorie P., Puttkammer, Nancy, Rakesh, Ankur, Rego, Ryan, Rhodes, Natalie, Romero, Waldo Vieyra, Saad, Randa K., Salih, Eman Mukhtar Nasr, Salim, Julian, Shaikh, Affan T., Soldan, Valerie A. Paz, Stelter, Romina, Streichert, Laura C., Sulesco, Tatiana, Sulieman, Rana, Suryantoro, Ludy, Suzuki, Satoru, Swisher, Samantha, Thakur, Siddhartha, Vazquez-Prokopec, Gonzalo M., Vieira, Rafael F.C., Vieira, Antonio R., Vumbugwa, Phiona, Waghray, Sejal, Wang, Shu-Hua, Wang, Xiaochun, Wassie, Tewodros A., Watson, Allison, Wells, Nyri Safiya, Wolman-Tardy, Koren, Wuhib, Tadesse, Yimer, Getnet, Zagar, Terence R., Zepeda Tello, Rodrigo, and Zhang, Lanyue
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- 2024
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27. Molecular analysis of the 2012 Bundibugyo virus disease outbreak
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Hulseberg, Christine E., Kumar, Raina, Di Paola, Nicholas, Larson, Peter, Nagle, Elyse R., Richardson, Joshua, Hanson, Jarod, Wauquier, Nadia, Fair, Joseph N., Makuwa, Maria, Mulembakani, Prime, Muyembe-Tamfum, Jean-Jacques, Schoepp, Randal J., Sanchez-Lockhart, Mariano, Palacios, Gustavo F., Kuhn, Jens H., and Kugelman, Jeffrey R.
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- 2021
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28. Molecular Evidence of Sexual Transmission of Ebola Virus
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Mate, Suzanne E., Kugelman, Jeffrey R., Nyenswah, Tolbert G., Ladner, Jason T., Wiley, Michael R., Cordier-Lassalle, Thierry, Christie, Athalia, Schroth, Gary P., Gross, Stephen M., Davies-Wayne, Gloria J., Shinde, Shivam A., Murugan, Ratnesh, Sieh, Sonpon B., Badio, Moses, Fakoli, Lawrence, Taweh, Fahn, de Wit, Emmie, van Doremalen, Neeltje, Munster, Vincent J., Pettitt, James, Prieto, Karla, Humrighouse, Ben W., Ströher, Ute, DiClaro, Joseph W., Hensley, Lisa E., Schoepp, Randal J., Safronetz, David, Fair, Joseph, Kuhn, Jens H., Blackley, David J., Laney, Scott A., Williams, Desmond E., Lo, Terrence, Gasasira, Alex, Nichol, Stuart T., Formenty, Pierre, Kateh, Francis N., De Cock, Kevin M., Bolay, Fatorma, Sanchez-Lockhart, Mariano, and Palacios, Gustavo
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- 2015
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29. The relationship between performance monitoring, satisfaction with life, and positive personality traits
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Larson, Michael J., Good, Daniel A., and Fair, Joseph E.
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- 2010
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30. Socializing One Health: an innovative strategy to investigate social and behavioral risks of emerging viral threats
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Saylors, Karen, Wolking, David J., Hagan, Emily, Martinez, Stephanie, Francisco, Leilani, Euren, Jason, Olson, Sarah H., Miller, Maureen, Fine, Amanda E., Thanh, Nga Nguyen Thi, Tran Minh, Phuc, Kalengkongan, Jusuf D., Kusumaningrum, Tina, Latinne, Alice, Pamungkas, Joko, Safari, Dodi, Saputro, Suryo, Bamba, Djeneba, Coulibaly, Kalpy Julien, Dosso, Mireille, Laudisoit, Anne, N'guettia Jean, Kouassi Manzan, Dutta, Shusmita, Islam, Ariful, Shano, Shahanaj, Mwanzalila, Mwokozi I., Trupin, Ian P., Gbakima, Aiah, Bangura, James, Yondah, Sylvester T., Karmacharya, Dibesh, Shrestha, Rima D., Kamta, Marcelle Annie Matsida, Mouiche, Mohamed Moctar Mouliom, Ndolo, Hilarion Moukala, Niama, Fabien Roch, Onikrotin, Dionne, Daszak, Peter, Johnson, Christine K., Mazet, Jonna A. K., Abaneh, Ola, Ababneh, Mustafa, Rafia, Jum, Sukor, Abd, Abdullah, Mohd Lufti, Abedin, Josefina, Abu-Basha, Ehab, Ali, Mohamed, Beal Akoundze, Junior, Akpaki, Joel, Al Hanandeh, Sief Addeen, Al Omari, Bilal, Al Shakil, Abdullah, Al-Zghoul, Mohammed, Albart, Stephenie Ann, Alshammari, Abdullah, Amarneh, Basil H., Ampofo, William, Andrew, Victoria, Ahn, Dao Le, Ankhanbaatar, Ulaankhuu, Anthony, Simon, Antonjaya, Ungke, Araya, Kidan, Arku, Jallah, Arshat, Norsharina, Asigbee, Theodore, Aung, Ohnmar, Awuni, Joseph, Ayukebong, James, Azian, Mohammed, Aziz, Nor Adilah, Ba, Aminata, Bassan, Ganzorig, Bagato, Ola, Bamba, Aboubacar, Bamba, Djenba, Barkhasbaatar, Ariunbaatar, Barrera, June, Basaraba, Cale, Bel-nono, Samuel, Belaganahalli, Manjunatha, Belay, Desalgen, Belkharia, Jaber, Binol, Ridzki M. F., Bird, Brian, Bista, Manisha, Biswas, Pitu, Blake, Matthew, Boatemaa, Linda, Bonason, Margret, Brandful, James, Brown, Joseph, Brownstein, John, Camara, Mamadi, Camara, Salif, Chai, Daniel, Chakraborty, Debapriyo, Chale, Hannah, Chaudhary, Ashok, Chea, Sokha, Chmura, Aleksei, Goossens, Benoit, Chow, Andrew, Churchill, Carolina, Commey, Abraham, Couacy-Hymann, Emmanuel, Coulibaly, Julien Kalpy, Cranfield, Michael, Damanik, Wirda, Damdinjav, Batchullum, Danial, Norhidayah, Dasak, Peter, David, Runie, Dawson, Patrick, Dembele, Arjouma, Deme, Awa, Desmond, James, Dewantari, Arghianditya Kresno, Dhanota, Jaseet, Dhole, Tapan, Diep, Nguyen Thi, Dionkounda, Artistide, Diop, Gaye Laye, Dodd, Kimberly, Dogby, Otilia, Dorjnyam, Tumendemberel, Dosso, Mireielle, Doumbouya, Kalil, Doumbouya, Mohamed Idriss, Doyle, Megan, Dramou, Simone, Drazenovich, Tracy, Duc Ahn, Dang, Duc Luu, Bach, Duendkae, Prateep, Duoc, Vu Trong, Duong, Tran Nhu, Duong, Veasna, Dursman, Huda, Dussart, Phillipe, Ee, Tan Jun, Ekiri, Abel, El Rifay, Amira S., El Shesheny, Rabel, El Taween, Ahmed N., Emmanuel, Zena Babu, Epstein, Jonathan H., Evans, Tierra Smiley, Fahmawi, Alaa, Fahn, Simeon, Feferholtz, Yasha, Ferdous, Jinnat, Fine, Amanda, Flora, Meerjady, Fransisco, Leilani, Fui Fui, Lem, Gabourie, Taylor, Gani, Millawati, Garbo, Michael, Gardner, Nicole, Gbamele, Marie, Ge, Xingyi, Gee, Lee Heng, Genovese, Brooke, Gibson, Alexandra, Gilardi, Kirsten, Gilbert, Martin, Gillis, Amethyst, Ginsos, Andrew, Godji Gnabro, Privat, Goldstein, Tracey, Gomaa, Moktar, Gomis, Jules, Gonzalez, Kevin, Grange, Zoe, Greig, Denise, Grodus, Michael, Gueu, Kpon Kakeuma Romeo, Gutierrez, Leticia, Haba, Dan Marcelin, Hamid, Suraya, Harris, Daniel K., Hashim, Abdul Kadir Abu, Hassan, Moushumi, Hassan, Quazar Nizamuddin, He, Qun, Hemachudha, Thiravat, Henry, Helen, Herbert, Ronald, Hijazeen, Zaidoun, Hilarion, Moukala Ndolo, Hill, Rebecca, Hoa, Nguyen Thi, Horwood, Paul, Hossain, Md. Enayet, Hossain, Saddam, Htun, Moh Moh, Hu, Ben, Hughes, Tom, Hul, Vibol, Van, Vo, Hussein, Fatima, Indola, Ghislain Dzeret, Iskandriati, Diah, Islam, Md. Tarikul, Islam, Shariful, Isnaim Ismail, Mohd, Ismail, Zuhair Bani, Iyanya, Jacques, Jaimin, Joel Judson, Jambai, Amara, Japning, Jeffrine Rovie Ryan, Japrin, Alexter, Jean Louis, Frantz, Joe, Titus, Johnson, Erica, Joly, Damien, Joshi, Jyotsna, Kalengkongan, Jusuf, Kalivogui, Douokoro, Kamara-Chieyoe, Nenneh, Kamau, Joseph, Kambale Syaluha, Eddy, Kandeil, Ahmed, Kane, Yogouba, Karesh, William, Kargo, Kandeh, Kasenda, Novie, Kayali, Ghazi, Kayed, Ahmed S., Kazwala, Rudovick, Ke, Changwen, Keates, Lucy, Kebede, Nigatu, Khamphaphongphane, Bouaphanh, Kheong, Chong Chee, Kilonzo, Christopher, Koffa, Ma-Sue, Kollie, Amos G., Kondiano, Marcel Sidik, Koropo, Michel, Kouamé Kouakou, Valere, Kouassi Koffi, Eugene, Kourouma, Mariam, Koutate, Abdoulaye Ousmane, Kowel, Citra Liv, Krou, Hermann Assemien, Kumakamba, Charles, Kutkat, Omnia, Lamah, François, Lan, Nguyen Thi, Lane, Jennifer, Lange, Christian, Larmouth, Emmanuel, Le Doux, Joseph Diffo, Leasure, Elizabeth, Leasure, Katherine, LeBreton, Mat, Lee, Jimmy, Lee, Helen, Lee, Mei Ho, Leno, Amara, Li, Hongying, Liang, Eliza, Liang, Neal, Lim, Dorothy, Lipkin, W. Ian, Liu, Jun, Lo, Modou Moustafa, Lojivis, Leonoris, Long, Nguyen Van, Lucas, Ashley, Lukusa, Jean Paul, Lungay, Victor, Lushima, Shongo, Lutwama, Julius, Ma, Wenjun, Machalaba, Catherine, Maganga, Grace, Magesa, Walter Simon, Mahmoud, Sara H., Makuwa, Maria, Makweta, Asha, Mamun, Abdullah Al, Manandhar, Prajwol, Maneeorn, Patarapol, Mann, Harjeet, Maomy, Bhele, Maptue, Victorine, Mathew, Alice, Mavoungou, Yanne Vanessa, Maw, Min Thein, Mazet, Jonna, Mbala, Placide, Mbuba, Emmanuel, Mbunwe, Eric, McIver, David, Mendelsohn, Emma, Miegakanda, Valchy Bel-Bebi, Minh, Phan Quang, Mkali, Happy, Moatasim, Yassmin, Mombouli, Jean Vivien, Monagin, Corina, Montecino-Latorre, Diego, Mossoun Mossoun, Arsene, Mostafa, Ahmed, Mouiche, Moctar, Mpassi, Romain Bagamboula, Msigwa, Alphonce, Mudakikwa, Antoine, Mugok, Laura Benedict, Mulembakani, Prime, Murray, Suzan, Musa, Fakhrul Hatta, Musabimana, Pacifique, Mutura, Samson, Mwamlima, Tunu, Mwanzanilla, Mwokozi, Myaing, Tin Tin, Myat, Theingi Win, Myo Chit, Aung, N’faly, Magassouba, N’Guettia, Manzan Jean, N’télo, Anatole, Nakimera, Sylivia, Nam, Vu Sinh, Napit, Rajindra, Nathan, Senthilvel K. S. S., Navarrete-Macias, Isamara, Ndebe, Kortu M., Ndiaye, Amadou, Ndiaye, Daouda, Negash, Yohannes, Nga, Nguyen Thi Thanh, Ngay, Ipos, Ngoc, Pham Thi Bich, Niama, Fabien, Nina, Rock Aimé, Niyonzima, Schadrack, Nkom, Felix, Nkoua, Cynthia, Noordin, Noorliza, Noviana, Rachmitasari, Nwobegahay, Julius, Nziza, Julius, O’Rourke, Daniel, O’Rourke, Tammie, Obodai, Evangeline, Okello Okwir, Ricky, Olival, Kevin, Olson, Sarah, Olva, Onkirotin Dionne, Ontiveros, Victoria, Opook, Fernandes, Panchadcharam, Chandrawathani, Pandit, Pranav, Parra, Henri-Joseph, Phuc, Tran Minh, Phuong, Nguyen Thanh, Poultolnor, Jackson Y., Pradhan, Saman, Preston, Eunah Cho, Pruvot, Mathieu, Purevtseren, Dulam, Puri, Dhiraj, Quang, Le Tin Vinh, Rachmitasari, Novie, Rahman, Kaisar, Rahman, Mizanur, Rahman, Mohammed Ziaur, Rahman, Mustafizur, Ramirez, Diana, Randhawa, Nistara, Raut, Samita, Rosario, Joseph, Ross, Albert, Ross, Noam, Rostal, Melinda, Roualdes, Pamela, Rubin, Eddy, Rumi, Aftab Uddin, Rundi, Christina, Sackie, Melkor, Sajali, Zikankuba, Samuels, Sandra G, Sango, Mathias, Saptu, Ammar Rafidah, Saraka, Daniel N’guessan, Sartee, Alvis A., Sayandouno, Sia Alida, Seck, Mame Cheikh, Sedor, Victoria, Sharma, Ajay Narayan, Sharminie, Velsri, Shehata, Mahmoud M., Sheikh, Gafur, Shi, Zhengli, Shiilegdamba, Enkhtuvshin, Shrestha, Bishwo, Shrestha, Rima, Sidibey, Mohammed, Silithammavong, Soubanh, Simon, Daniel, Sion, Emilly, Sipangkui, Symphorosa, Sitam, Frankie Thomas, Smith, Brett, Smith, Bridgette, Smith, Woutrina, Sodnom, Batsikhan, Ssebide, Benard, Suleiman, Maria, Sullivan, Ava, Sungif, Nur Amirah, Suu-Ire, Richard, Sy, Mouhamed, Takuo, Jean Michel, Talafha, Hani, Tamoufe, Ubald, Tetteh, Emmanuel, Than Toe, Aung, Thanda, Lanash, Thanh Long, Ngo, Thein, Wai Zin, Theppangna, Watthana, Thinh, Nguyen Duc, Thuy, Hoang Bich, Thuy, Nguyen Thu, Togami, Eri, Tolno, Moise Bendoua, Tolovou, Kevin, Topani, Rahmat, Tremeau-Bravard, Alexandre, Trupin, Ian, Tumushime, Jean Claude, Tun, Kyaw Yan Naing, Turay, Joseph, Uddin, Helal, Uhart, Marcela, Ureda, Nicole, Valitutto, Marc, Verasahib, Khebir, Vodzak, Megan, Wacharapluesadee, Supaporn, Wahad, Mohammad Yuery Wazlan Abdul, Watson, Brooke, Wells, Heather, White, Allison, Willoughby, Anna, Wiyatno, Ageng, Wolking, David, Yang, Xinglou, Yao, Lim Ming, Yombouno, Sayon, Young, Cristin, Zambrana-Torrelio, Carlos, Zeid, Zahidah Izzati, Zghoul, Ghadeer, Zhang, Libiao, Zhang, Yunzhi, Zhu, Guangjian, Zimmerman, Dawn, Zoumarou, Daba, Aguirre, Alonso, Aguirre, Luis, Akongo, Mark-Joel, Alandia Robles, Erika, Ambu, Laurentius, Ayala Aguilar, Glenda, Barcena, Luis, Barradas, Rosario, Basir, Misliah Mohamad, Bogich, Tiffany, Bounga, Gerard, Buchy, Philippe, Bunn, David, Byaruba, Denis, Cameron, Ken, Carroll, Dennis, Cavero, Nancy, Cespedes, Manuel, Che, Xiaoyu, Chiu, Charles, Chor, Kimashalen, Clements, Andrew, Dary Acevedo, Luz, de Almeida Campos, Angelica, De La Puente, Micaela, de Lamballerie, Xavier, de Paula, Catia, Delwart, Eric, Diffo Le Doux, Joseph, Doyle-Capitman, Catherine, Durigon, Edison, Fair, Joseph, Ferrer-Paris, José R., Formenty, Pierre, Galarza, Isabel, Garcia, Joel, Grard, Gilda, Greatorex, Zoe, Harris, Laurie, Hitchens, Peta, Ho, Mei, Hosseini, Parviez, In, Samath, Iñíguez, Volga, Jain, Komal, Jamaluddin, Abd. Aziz, Johnson, Christine, Jones, Kate, Joyner, Priscilla, Kaba, Serge, Kambale, Eddy, Kataregga, Abdulhameed, Kelly, Terra, Khammavong, Kongsy, Kilpatrick, A. Marm, Laimun, Samsir, Lee, Mei-Ho, LeRoy, Eric, Levinson, Jordan, Levy, Marc, Limachi, Rolando, Loh, Elizabeth, Lowenstine, Linda J., Luis Mollericona, José, Maganga, Ruth, Malakalinga, Joseph, Manhas, Melissa, Marra, Pete, Mbabazi, Rachael, Medellín, Rodrigo, Mendoza, Patricia, Miller, Sireeda, Miranda, Flavia, Mitchell, Megan, Mohamed, Ramlan, Mollard, Debbie, Morse, Stephen, Mouellet, Wivine, Moya, Isabel, Murillo, Yovanna, Murray, Kris, Muyembe Tamfum, Jean-Jacques, Nassar, Fernando, Nathan, Sen, Nsengimana, Olivier, Ogg Keatts, Lucy, Ojeda-Flore, Rafael, Okwir Okello, Ricky, Ondzie, Alain, Paweska, Janusz, Pereira, Alisa, Pereira, Victoria, Perez, Alberto, Perez, Jocelyn, Phon, Simorn, Reed, Patricia, Rejmanek, Dan, Rico, Oscar, Rivera, Rosario, Romero, Monica, Roy, Celina, Saepuloh, Uus, Schneider, Brad, Schwind, Jessica, Singhalath, Sinpakhome, Smith, Kristine, Suárez, Fabiola, Suzan, Gerardo, Thanh Nga, Nguyen Thi, Thomas, Kate, Ticona, Herminio, VanWormer, Elizabeth, Villar, Sandra, Weisman, Wendy, Westfall, Michael, Whittier, Chris, Wicker, Leanne, Wolfe, Nathan, Yang, Angela, Zariquiey, Carlos, Zhang, Shu-Yi, Zorine Nkouants, Baudelaire, Zainuddin, Zainal, Chrisman, Cara, Pabst, August, Shek, Amalhin, and Trostle, Murray
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0301 basic medicine ,Behavioral risk ,medicine.medical_specialty ,Behavioural sciences ,Disease ,Community integration ,Basic Behavioral and Social Science ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,2.3 Psychological ,Behavioral and Social Science ,Agency (sociology) ,medicine ,2.2 Factors relating to the physical environment ,GE1-350 ,Aetiology ,One health ,Social science research ,business.industry ,Prevention ,Research ,Public health ,PREDICT Consortium ,Public relations ,Focus group ,Environmental sciences ,Good Health and Well Being ,030104 developmental biology ,One Health ,Multi-disciplinary surveillance ,social and economic factors ,Public aspects of medicine ,RA1-1270 ,Infection ,Psychology ,International development ,business ,030217 neurology & neurosurgery - Abstract
In an effort to strengthen global capacity to prevent, detect, and control infectious diseases in animals and people, the United States Agency for International Development’s (USAID) Emerging Pandemic Threats (EPT) PREDICT project funded development of regional, national, and local One Health capacities for early disease detection, rapid response, disease control, and risk reduction. From the outset, the EPT approach was inclusive of social science research methods designed to understand the contexts and behaviors of communities living and working at human-animal-environment interfaces considered high-risk for virus emergence. Using qualitative and quantitative approaches, PREDICT behavioral research aimed to identify and assess a range of socio-cultural behaviors that could be influential in zoonotic disease emergence, amplification, and transmission. This broad approach to behavioral risk characterization enabled us to identify and characterize human activities that could be linked to the transmission dynamics of new and emerging viruses. This paper provides a discussion of implementation of a social science approach within a zoonotic surveillance framework. We conducted in-depth ethnographic interviews and focus groups to better understand the individual- and community-level knowledge, attitudes, and practices that potentially put participants at risk for zoonotic disease transmission from the animals they live and work with, across 6 interface domains. When we asked highly-exposed individuals (ie. bushmeat hunters, wildlife or guano farmers) about the risk they perceived in their occupational activities, most did not perceive it to be risky, whether because it was normalized by years (or generations) of doing such an activity, or due to lack of information about potential risks. Integrating the social sciences allows investigations of the specific human activities that are hypothesized to drive disease emergence, amplification, and transmission, in order to better substantiate behavioral disease drivers, along with the social dimensions of infection and transmission dynamics. Understanding these dynamics is critical to achieving health security--the protection from threats to health-- which requires investments in both collective and individual health security. Involving behavioral sciences into zoonotic disease surveillance allowed us to push toward fuller community integration and engagement and toward dialogue and implementation of recommendations for disease prevention and improved health security. Supplementary Information The online version contains supplementary material available at 10.1186/s42522-021-00036-9.
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- 2021
31. Arenaviruses
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Sauvage, Frank, primary, Fair, Joseph, additional, and Gonzalez, Jean-Paul, additional
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- 2014
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32. List of Contributors
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Al-Tawfiq, Jaffar A., primary, Arikan-Akdagli, Sevtap, additional, Avšič Županc, Tatjana, additional, Azap, Alpay, additional, Bausch, Daniel G., additional, Bulent Ertugrul, M., additional, Charrel, Remi N., additional, Chiu, Charles, additional, Cramer, Jakob P., additional, Di Bella, Stefano, additional, Dortet, Laurent, additional, Drapeau, Cecilia Melina, additional, Ebihara, Hideki, additional, Ergönül, Önder, additional, Ergunay, Koray, additional, Fair, Joseph, additional, Feldmann, Heinz, additional, Formenty, Pierre, additional, Grant, Donald S., additional, Grard, Gilda, additional, Heyckendorf, Jan, additional, Huang, Gene Khai Lin, additional, Johnson, Paul, additional, Kato, Yasuyuki, additional, Khan, Humarr, additional, Korva, Miša, additional, Lange, Christoph, additional, Leroy, Eric, additional, Lutwick, Larry, additional, Martensen, Julia, additional, Matsuno, Keita, additional, Mawatari, Momoko, additional, Memish, Ziad A., additional, Mizuno, Yasutaka, additional, Nakamura, Itaru, additional, Nordmann, Patrice, additional, Paweska, Janusz T., additional, Pehlivanoglu, Filiz, additional, Petrosillo, Nicola, additional, Petrovec, Miroslav, additional, Poirel, Laurent, additional, Preis, Jana, additional, Rezza, Giovanni, additional, Rollin, Pierre E., additional, Schieffelin, John, additional, Stanek, Gerold, additional, Strle, Franc, additional, Stupica, Daša, additional, and Uršič, Tina, additional
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- 2014
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33. Bas-Congo Virus
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Grard, Gilda, primary, Fair, Joseph, additional, Chiu, Charles, additional, and Leroy, Eric, additional
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- 2014
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34. Failure to Detect Simian Immunodeficiency Virus Infection in a Large Cameroonian Cohort with High Non-human Primate Exposure
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Djoko, Cyrille F., Wolfe, Nathan D., Aghokeng, Avelin F., LeBreton, Matthew, Liegeois, Florian, Tamoufe, Ubald, Schneider, Bradley S., Ortiz, Nancy, Mbacham, Wilfred F., Carr, Jean K., Rimoin, Anne W., Fair, Joseph N., Pike, Brian L., Mpoudi-Ngole, Eitel, Delaporte, Eric, Burke, Donald S., and Peeters, Martine
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- 2012
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35. High seroprevalence of enterovirus infections in apes and old world monkeys
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Harvala, Heli, McIntyre, Chloe L., Imai, Natsuko, Clasper, Lucy, Djoko, Cyrille F., LeBreton, Matthew, Vermeulen, Marion, Saville, Andrew, Mutapi, Francisca, Tamoufe, Ubald, Kiyang, John, Biblia, Tafon G., Midzi, Nicholas, Mduluza, Takafira, Pepin, Jacques, Njoum, Richard, Smura, Teemu, Fair, Joseph N., Wolfe, Nathan D., Roivainen, Merja, and Simmonds, Peter
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Apes -- Health aspects ,Primates -- Health aspects ,Health - Abstract
Enteroviruses (EVs) form a diverse genus in the virus family Picornaviridae. EVs that infect humans are divided genetically into 4 species (EV A-D), and each contains numerous antigenically distinct serotypes [...]
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- 2012
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36. New opportunities for field research on the pathogenesis and treatment of Lassa fever
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Khan, Sheik Humarr, Goba, Augustine, Chu, May, Roth, Cathy, Healing, Tim, Marx, Arthur, Fair, Joseph, Guttieri, Mary C., Ferro, Philip, Imes, Tiffany, Monagin, Corina, Garry, Robert F., and Bausch, Daniel G.
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- 2008
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37. Bas-Congo virus: another deadly virus?
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Chiu, Charles, Fair, Joseph, and Leroy, Eric M
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- 2013
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38. High heart rate at admission as a predictive factor of mortality in hospitalized patients with Lassa fever: An observational cohort study in Sierra Leone
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Wauquier, Nadia, primary, Couffignal, Camille, additional, Manchon, Pauline, additional, Smith, Elisabeth, additional, Lungay, Victor, additional, Coomber, Moinya, additional, Weisenfluh, Lauren, additional, Bangura, James, additional, Khan, Sheik Humarr, additional, Jambai, Amara, additional, Gbakima, Aiah, additional, Yun, Nadezda, additional, Paessler, Slobodan, additional, Schoepp, Randal, additional, Morse, Stephen S., additional, Gonzalez, Jean-Paul, additional, Fair, Joseph, additional, Mentré, France, additional, and Vieillard, Vincent, additional
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- 2020
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39. Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: Case Report
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Fonnie Mbalu, Schoepp Randal J, Bangura James J, Robinson James E, Schieffellin John S, Henderson Lee A, Muncy Ivana J, Boisen Matt L, Grove Jessica N, Branco Luis M, Hensley Lisa E, Seisay Alhassan, Fair Joseph N, and Garry Robert F
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Lassa fever is a neglected tropical disease with a significant impact on the health care system of endemic West African nations. To date, case reports of Lassa fever have focused on laboratory characterisation of serological, biochemical and molecular aspects of the disease imported by infected individuals from Western Africa to the United States, Canada, Europe, Japan and Israel. Our report presents the first comprehensive real time diagnosis and characterization of a severe, hemorrhagic Lassa fever case in a Sierra Leonean individual admitted to the Kenema Government Hospital Lassa Fever Ward. Fever, malaise, unresponsiveness to anti-malarial and antibiotic drugs, followed by worsening symptoms and onset of haemorrhaging prompted medical officials to suspect Lassa fever. A recombinant Lassa virus protein based diagnostic was employed in diagnosing Lassa fever upon admission. This patient experienced a severe case of Lassa hemorrhagic fever with dysregulation of overall homeostasis, significant liver and renal system involvement, the interplay of pro- and anti-inflammatory cytokines during the course of hospitalization and an eventual successful outcome. These studies provide new insights into the pathophysiology and management of this viral illness and outline the improved infrastructure, research and real-time diagnostic capabilities within LASV endemic areas.
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- 2011
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40. Uncoupling GP1 and GP2 expression in the Lassa virus glycoprotein complex: implications for GP1 ectodomain shedding
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Illick Kerry A, Fair Joseph N, Branco Luis M, Illick Megan M, Matschiner Alex, Schoepp Randal, Garry Robert F, and Guttieri Mary C
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Sera from convalescent Lassa fever patients often contains antibodies to Lassa virus (LASV) glycoprotein 1 (GP1), and glycoprotein 2 (GP2); Immunization of non-human primates with viral vectors expressing the arenaviral glycoprotein complex (GPC) confers full protective immunity against a lethal challenge with LASV. Thus, the development of native or quasi native recombinant LASV GP1 and GP2 as soluble, uncoupled proteins will improve current diagnostics, treatment, and prevention of Lassa fever. To this end, mammalian expression systems were engineered for production and purification of secreted forms of soluble LASV GP1 and GP2 proteins. Results Determinants for mammalian cell expression of secreted uncoupled Lassa virus (LASV) glycoprotein 1 (GP1) and glycoprotein 2 (GP2) were established. Soluble GP1 was generated using either the native glycoprotein precursor (GPC) signal peptide (SP) or human IgG signal sequences (s.s.). GP2 was secreted from cells only when (1) the transmembrane (TM) domain was deleted, the intracellular domain (IC) was fused to the ectodomain, and the gene was co-expressed with a complete GP1 gene in cis; (2) the TM and IC domains were deleted and GP1 was co-expressed in cis; (3) expression of GP1 was driven by the native GPC SP. These data implicate GP1 as a chaperone for processing and shuttling GP2 to the cell surface. The soluble forms of GP1 and GP2 generated through these studies were secreted as homogeneously glycosylated proteins that contained high mannose glycans. Furthermore, observation of GP1 ectodomain shedding from cells expressing wild type LASV GPC represents a novel aspect of arenaviral glycoprotein expression. Conclusion These results implicate GP1 as a chaperone for the correct processing and shuttling of GP2 to the cell surface, and suggest that native GPC SP plays a role in this process. In the absence of GP1 and GPC SP the GP2 protein may be processed by an alternate pathway that produces heterogeneously glycosylated protein, or the polypeptide may not fully mature in the secretory cascade in mammalian cells. The expression constructs developed in these studies resulted in the generation and purification of soluble, uncoupled GP1 and GP2 proteins from mammalian cells with quasi-native properties. The observation of GP1 ectodomain shedding from cells expressing wild type LASV GPC establishes new correlates of disease progression and highlights potential opportunities for development of diagnostics targeting the early stages of Lassa fever.
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- 2008
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41. Bacterial-based systems for expression and purification of recombinant Lassa virus proteins of immunological relevance
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Cashman Kathleen A, Ferro Philip J, Sampey Darryl B, Goba Augustine, Fair Joseph N, Matschiner Alex, Branco Luis M, Schoepp Randal J, Tesh Robert B, Bausch Daniel G, Garry Robert F, and Guttieri Mary C
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background There is a significant requirement for the development and acquisition of reagents that will facilitate effective diagnosis, treatment, and prevention of Lassa fever. In this regard, recombinant Lassa virus (LASV) proteins may serve as valuable tools in diverse antiviral applications. Bacterial-based systems were engineered for expression and purification of recombinant LASV nucleoprotein (NP), glycoprotein 1 (GP1), and glycoprotein 2 (GP2). Results Full-length NP and the ectodomains of GP1 and GP2 were generated as maltose-binding protein (MBP) fusions in the Rosetta strains of Escherichia coli (E. coli) using pMAL-c2x vectors. Average fusion protein yields per liter of culture for MBP-NP, MBP-GP1, and MBP-GP2 were 10 mg, 9 mg, and 9 mg, respectively. Each protein was captured from cell lysates using amylose resin, cleaved with Factor Xa, and purified using size-exclusion chromatography (SEC). Fermentation cultures resulted in average yields per liter of 1.6 mg, 1.5 mg, and 0.7 mg of purified NP, GP1 and GP2, respectively. LASV-specific antibodies in human convalescent sera specifically detected each of the purified recombinant LASV proteins, highlighting their utility in diagnostic applications. In addition, mouse hyperimmune ascitic fluids (MHAF) against a panel of Old and New World arenaviruses demonstrated selective cross reactivity with LASV proteins in Western blot and enzyme-linked immunosorbent assay (ELISA). Conclusion These results demonstrate the potential for developing broadly reactive immunological assays that employ all three arenaviral proteins individually and in combination.
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- 2008
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42. DNA indicative of human bocaviruses detected in non-human primates in the Democratic Republic of the Congo
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Kumakamba, Charles, primary, Ngay Lukusa, Ipos, additional, Mbala Kingebeni, Placide, additional, N’Kawa, Frida, additional, Atibu Losoma, Joseph, additional, Mulembakani, Prime M., additional, Makuwa, Maria, additional, Muyembe Tamfum, Jean-Jacques, additional, Belais, Raphaël, additional, Gillis, Amethyst, additional, Harris, Stephen, additional, Rimoin, Anne W., additional, Hoff, Nicole A., additional, Fair, Joseph N., additional, Monagin, Corina, additional, Ayukekbong, James, additional, Rubin, Edward M., additional, Wolfe, Nathan D., additional, and Lange, Christian E., additional
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- 2018
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43. High Herpesvirus Diversity in Wild Rodent and Shrew Species in Central Africa
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Ntumvi, Nkom Felix, primary, Mbala Kingebeni, Placide, additional, Tamoufe, Ubald, additional, Kumakamba, Charles, additional, Ndze, Valentine, additional, Ngay Lukusa, Ipos, additional, LeBreton, Matthew, additional, Atibu Losoma, Joseph, additional, Le Doux Diffo, Joseph, additional, N’Kawa, Frida, additional, Takuo, Jean-Michel, additional, Mulembakani, Prime, additional, Nwobegahay, Julius, additional, Makuwa, Maria, additional, Muyembe Tamfum, Jean J., additional, Gillis, Amethyst, additional, Harris, Stephen, additional, Rimoin, Anne W., additional, Hoff, Nicole A., additional, Fair, Joseph M., additional, Monagin, Corina, additional, Ayukekbong, James, additional, Rubin, Edward M., additional, Wolfe, Nathan D., additional, and Lange, Christian E., additional
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- 2018
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44. Serosurveillance of viral pathogens circulating in West Africa
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O’Hearn, Aileen E., primary, Voorhees, Matthew A., additional, Fetterer, David P., additional, Wauquier, Nadia, additional, Coomber, Moinya R., additional, Bangura, James, additional, Fair, Joseph N., additional, Gonzalez, Jean-Paul, additional, and Schoepp, Randal J., additional
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- 2016
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45. Correction: A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa
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Grard, Gilda, primary, Fair, Joseph N., additional, Lee, Deanna, additional, Slikas, Elizabeth, additional, Steffen, Imke, additional, Muyembe, Jean-Jacques, additional, Sittler, Taylor, additional, Veeraraghavan, Narayanan, additional, Ruby, J. Graham, additional, Wang, Chunlin, additional, Makuwa, Maria, additional, Mulembakani, Prime, additional, Tesh, Robert B., additional, Mazet, Jonna, additional, Rimoin, Anne W., additional, Taylor, Travis, additional, Schneider, Bradley S., additional, Simmons, Graham, additional, Delwart, Eric, additional, Wolfe, Nathan D., additional, Chiu, Charles Y., additional, and Leroy, Eric M., additional
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- 2016
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46. Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection
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Yun, Nadezhda E., primary, Ronca, Shannon, additional, Tamura, Atsushi, additional, Koma, Takaaki, additional, Seregin, Alexey V., additional, Dineley, Kelly T., additional, Miller, Milagros, additional, Cook, Rebecca, additional, Shimizu, Naoki, additional, Walker, Aida G., additional, Smith, Jeanon N., additional, Fair, Joseph N., additional, Wauquier, Nadia, additional, Bockarie, Bayon, additional, Khan, Sheik Humarr, additional, Makishima, Tomoko, additional, and Paessler, Slobodan, additional
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- 2016
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47. Evolution and Spread of Ebola Virus in Liberia, 2014–2015
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Ladner, Jason T., primary, Wiley, Michael R., additional, Mate, Suzanne, additional, Dudas, Gytis, additional, Prieto, Karla, additional, Lovett, Sean, additional, Nagle, Elyse R., additional, Beitzel, Brett, additional, Gilbert, Merle L., additional, Fakoli, Lawrence, additional, Diclaro, Joseph W., additional, Schoepp, Randal J., additional, Fair, Joseph, additional, Kuhn, Jens H., additional, Hensley, Lisa E., additional, Park, Daniel J., additional, Sabeti, Pardis C., additional, Rambaut, Andrew, additional, Sanchez-Lockhart, Mariano, additional, Bolay, Fatorma K., additional, Kugelman, Jeffrey R., additional, and Palacios, Gustavo, additional
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- 2015
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48. First Detection of an Enterovirus C99 in a Captive Chimpanzee with Acute Flaccid Paralysis, from the Tchimpounga Chimpanzee Rehabilitation Center, Republic of Congo
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Mombo, Illich Manfred, primary, Berthet, Nicolas, additional, Lukashev, Alexander N., additional, Bleicker, Tobias, additional, Brünink, Sebastian, additional, Léger, Lucas, additional, Atencia, Rebeca, additional, Cox, Debby, additional, Bouchier, Christiane, additional, Durand, Patrick, additional, Arnathau, Céline, additional, Brazier, Lionel, additional, Fair, Joseph N., additional, Schneider, Bradley S., additional, Drexler, Jan Felix, additional, Prugnolle, Franck, additional, Drosten, Christian, additional, Renaud, François, additional, Leroy, Eric M., additional, and Rougeron, Virginie, additional
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- 2015
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49. Evidence of Lymphocytic Choriomeningitis Virus (LCMV) in Domestic Mice in Gabon: Risk of Emergence of LCMV Encephalitis in Central Africa
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N′Dilimabaka, Nadine, primary, Berthet, Nicolas, additional, Rougeron, Virginie, additional, Mangombi, Joa Braïthe, additional, Durand, Patrick, additional, Maganga, Gael D., additional, Bouchier, Christiane, additional, Schneider, Bradley S., additional, Fair, Joseph, additional, Renaud, François, additional, and Leroy, Eric M., additional
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- 2015
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50. Understanding the Emergence of Ebola Virus Disease in Sierra Leone: Stalking the Virus in the Threatening Wake of Emergence
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Wauquier, Nadia, primary, Bangura, James, additional, Moses, Lina, additional, Humarr Khan, Sheik, additional, Coomber, Moinya, additional, Lungay, Victor, additional, Gbakie, Michael, additional, Sesay, Mohammed S.K., additional, Gassama, Ibrahim A.K., additional, Massally, James L.B., additional, Gbakima, Aiah, additional, Squire, James, additional, Lamin, Mohamed, additional, Kanneh, Lansana, additional, Yillah, Mohammed, additional, Kargbo, Kandeh, additional, Roberts, Willie, additional, Vandi, Mohammed, additional, Kargbo, David, additional, Vincent, Tom, additional, Jambai, Amara, additional, Guttieri, Mary, additional, Fair, Joseph, additional, Souris, Marc, additional, and Gonzalez, Jean Paul, additional
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- 2015
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