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26 results on '"Faienza, Fiorella"'

2. AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation

Author

Faienza, Fiorella, Polverino, Federica, Rajendraprasad, Girish, Milletti, Giacomo, Hu, Zehan, Colella, Barbara, Gargano, Deborah, Strappazzon, Flavie, Rizza, Salvatore, Vistesen, Mette Vixø, Luo, Yonglun, Antonioli, Manuela, Cianfanelli, Valentina, Ferraina, Caterina, Fimia, Gian Maria, Filomeni, Giuseppe, De Zio, Daniela, Dengjel, Joern, Barisic, Marin, Guarguaglini, Giulia, Di Bartolomeo, Sabrina, and Cecconi, Francesco

Published
2023
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3. GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation

Author

Rizza, Salvatore, Di Leo, Luca, Pecorari, Chiara, Giglio, Paola, Faienza, Fiorella, Montagna, Costanza, Maiani, Emiliano, Puglia, Michele, Bosisio, Francesca M., Petersen, Trine Skov, Lin, Lin, Rissler, Vendela, Viloria, Juan Salamanca, Luo, Yonglun, Papaleo, Elena, De Zio, Daniela, Blagoev, Blagoy, and Filomeni, Giuseppe

Published
2023
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5. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue

Author

Rosina, Marco, Ceci, Veronica, Turchi, Riccardo, Li, Chuan, Borcherding, Nicholas, Sciarretta, Francesca, Sánchez-Díaz, María, Tortolici, Flavia, Karlinsey, Keaton, Chiurchiù, Valerio, Fuoco, Claudia, Giwa, Rocky, Field, Rachael L., Audano, Matteo, Arena, Simona, Palma, Alessandro, Riccio, Federica, Shamsi, Farnaz, Renzone, Giovanni, Verri, Martina, Crescenzi, Anna, Rizza, Salvatore, Faienza, Fiorella, Filomeni, Giuseppe, Kooijman, Sander, Rufini, Stefano, de Vries, Antoine A.F., Scaloni, Andrea, Mitro, Nico, Tseng, Yu-Hua, Hidalgo, Andrés, Zhou, Beiyan, Brestoff, Jonathan R., Aquilano, Katia, and Lettieri-Barbato, Daniele

Published
2022
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7. Loss of Ambra1 promotes melanoma growth and invasion

Author

Di Leo, Luca, Bodemeyer, Valérie, Bosisio, Francesca M., Claps, Giuseppina, Carretta, Marco, Rizza, Salvatore, Faienza, Fiorella, Frias, Alex, Khan, Shawez, Bordi, Matteo, Pacheco, Maria P., Di Martino, Julie, Bravo-Cordero, Jose J., Daniel, Colin J., Sears, Rosalie C., Donia, Marco, Madsen, Daniel H., Guldberg, Per, Filomeni, Giuseppe, Sauter, Thomas, Robert, Caroline, De Zio, Daniela, and Cecconi, Francesco

Published
2021
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8. Contributors

Author

Aranda, Enrique, primary, Azizi, Fereidoun, additional, Bahadoran, Zahra, additional, Baritaki, Stavroula, additional, Barresi, Elisabetta, additional, Bonavida, Benjamin, additional, Bucolo, Claudio, additional, Calderone, Vincenzo, additional, Chegaev, Konstantin, additional, Chlopicki, Stefan, additional, Ciccone, Valerio, additional, Citi, Valentina, additional, Clementi, Emilio, additional, Da Settimo, Federico, additional, da Silva, Rafaella C., additional, Donadelli, Massimo, additional, Donnini, Sandra, additional, Drago, Filippo, additional, Dulak, Józef, additional, Durán, Nelson, additional, Durante, Miriam, additional, Ekmekcioglu, Suhendan, additional, Faienza, Fiorella, additional, Fávaro, Wagner J., additional, Ferraz, Letícia, additional, Filomeni, Giuseppe, additional, Forte, Elena, additional, Frosini, Maria, additional, Fusi, Fabio, additional, Gazzano, Elena, additional, Ghasemi, Asghar, additional, Gheibi, Sevda, additional, Gholami, Hanieh, additional, Giglio, Paola, additional, Giuffrè, Alessandro, additional, Grimm, Elizabeth A., additional, Jeddi, Sajad, additional, Kashfi, Khosrow, additional, Kim, Sun-Hee, additional, Kim, Won Jong, additional, Kopecka, Joanna, additional, Lazzeri, Luca, additional, Leggio, Gian Marco, additional, Malagrinò, Francesca, additional, Martelli, Alma, additional, Mascolo, Ludovica, additional, Mastronicola, Daniela, additional, Mirmiran, Parvin, additional, Monteiro, Hugo P., additional, Morbidelli, Lucia, additional, Myant, Kevin, additional, Nandi, Dipankar, additional, Ogata, Dai, additional, Pagnotta, Eleonora, additional, Papapetropoulos, Andreas, additional, Park, Dongsik, additional, Pathak, Sanmoy, additional, Pelegrino, Milena T., additional, Peñarando, Jon, additional, Perrotta, Cristiana, additional, Luzia Pinto, Moisés, additional, Vieira Pinto, Rosana, additional, Piragine, Eugenia, additional, Pittalà, Valeria, additional, Platania, Chiara Bianca Maria, additional, Reis, Adriana K.C.A., additional, Riganti, Chiara, additional, Rizza, Salvatore, additional, Rodrigue, Tiago, additional, Rodriguez-Ariza, Antonio, additional, Rolando, Barbara, additional, Roszik, Jason, additional, Rubinstein, Menachem, additional, Salaroglio, Iris C., additional, Salomone, Salvatore, additional, Saponara, Simona, additional, Saravanakumar, Gurusamy, additional, Scicinski, Jan, additional, Seabra, Amedea B., additional, Stern, Arnold, additional, Supuran, Claudiu T., additional, Taliani, Sabrina, additional, Testai, Lara, additional, Ugolini, Luisa, additional, Vannini, Federica, additional, Varchi, Greta, additional, Venturelli, Massimo, additional, Verma, Taru, additional, Vicente, João B., additional, Yadav, Shikha, additional, Ziche, Marina, additional, and Zuhra, Karim, additional

Published
2019
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10. TRAP1S-nitrosylation as a model of population-shift mechanism to study the effects of nitric oxide on redox-sensitive oncoproteins

Author

Papaleo, Elena, primary, Tiberti, Matteo, additional, Arnaudi, Matteo, additional, Pecorari, Chiara, additional, Faienza, Fiorella, additional, Cantwell, Lisa, additional, Degn, Kristine, additional, Pacello, Francesca, additional, Battistoni, Andrea, additional, Lambrughi, Matteo, additional, and Filomeni, Giuseppe, additional

Published
2022
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13. Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780)

Author

Chiappetta, Giovanni, Gamberi, Tania, Faienza, Fiorella, Limaj, Xhesika, Rizza, Salvatore, Messori, Luigi, Filomeni, Giuseppe, Modesti, Alessandra, Vinh, Joelle, Chiappetta, Giovanni, Gamberi, Tania, Faienza, Fiorella, Limaj, Xhesika, Rizza, Salvatore, Messori, Luigi, Filomeni, Giuseppe, Modesti, Alessandra, and Vinh, Joelle

Abstract

The effects of Auranofin (AF) on protein expression and protein oxidation in A2780 cancer cells were investigated through a strategy based on simultaneous expression proteomics and redox proteomics determinations. Bioinformatics analysis of the proteomics data supports the view that the most critical cellular changes elicited by AF treatment consist of thioredoxin reductase inhibition, alteration of the cell redox state, impairment of the mitochondrial functions, metabolic changes associated with conversion to a glycolytic phenotype, induction of ER stress. The occurrence of the above cellular changes was extensively validated by performing direct biochemical assays. Our data are consistent with the concept that AF produces its effects through a multitarget mechanism that mainly affects the redox metabolism and the mitochondrial functions and results into severe ER stress. Results are discussed in the context of the current mechanistic knowledge existing on AF., The effects of Auranofin (AF) on protein expression and protein oxidation in A2780 cancer cells were investigated through a strategy based on simultaneous expression proteomics and redox proteomics determinations. Bioinformatics analysis of the proteomics data supports the view that the most critical cellular changes elicited by AF treatment consist of thioredoxin reductase inhibition, alteration of the cell redox state, impairment of the mitochondrial functions, metabolic changes associated with conversion to a glycolytic phenotype, induction of ER stress. The occurrence of the above cellular changes was extensively validated by performing direct biochemical assays. Our data are consistent with the concept that AF produces its effects through a multitarget mechanism that mainly affects the redox metabolism and the mitochondrial functions and results into severe ER stress. Results are discussed in the context of the current mechanistic knowledge existing on AF.

Published
2022

16. S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli

Author

Faienza, Fiorella, Lambrughi, Matteo, Rizza, Salvatore, Pecorari, Chiara, Giglio, Paola, Viloria, Juan Salamanca, Allega, Maria Francesca, Chiappetta, Giovanni, Vinh, Joelle, Pacello, Francesca, Battistoni, Andrea, Rasola, Andrea, Papaleo, Elena, Filomeni, Giuseppe, Faienza, Fiorella, Lambrughi, Matteo, Rizza, Salvatore, Pecorari, Chiara, Giglio, Paola, Viloria, Juan Salamanca, Allega, Maria Francesca, Chiappetta, Giovanni, Vinh, Joelle, Pacello, Francesca, Battistoni, Andrea, Rasola, Andrea, Papaleo, Elena, and Filomeni, Giuseppe

Published
2020

18. S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli

Author

Faienza, Fiorella, primary, Lambrughi, Matteo, additional, Rizza, Salvatore, additional, Pecorari, Chiara, additional, Giglio, Paola, additional, Salamanca Viloria, Juan, additional, Allega, Maria Francesca, additional, Chiappetta, Giovanni, additional, Vinh, Joëlle, additional, Pacello, Francesca, additional, Battistoni, Andrea, additional, Rasola, Andrea, additional, Papaleo, Elena, additional, and Filomeni, Giuseppe, additional

Published
2020
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20. S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli

Author

Faienza, Fiorella, primary, Lambrughi, Matteo, additional, Rizza, Salvatore, additional, Pecorari, Chiara, additional, Giglio, Paola, additional, Viloria, Juan Salamanca, additional, Allega, Maria Francesca, additional, Chiappetta, Giovanni, additional, Vinh, Joëlle, additional, Pacello, Francesca, additional, Battistoni, Andrea, additional, Rasola, Andrea, additional, Papaleo, Elena, additional, and Filomeni, Giuseppe, additional

Published
2019
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23. Characterization of three novel pathogenic SLC40A1 mutations and genotype/phenotype correlations in 7 Italian families with type 4 hereditary hemochromatosis

Author

Majore, Silvia, primary, Bonaccorsi di Patti, Maria Carmela, additional, Valiante, Michele, additional, Polticelli, Fabio, additional, Cortese, Andrea, additional, Di Bartolomeo, Sabrina, additional, De Bernardo, Carmelilia, additional, De Muro, Marianna, additional, Faienza, Fiorella, additional, Radio, Francesca Clementina, additional, Grammatico, Paola, additional, and Musci, Giovanni, additional

Published
2018
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24. AMBRA1 phosphorylation during mitosis

Author

Faienza, Fiorella, Antonioli, Manuela, Cianfanelli, Valentina, Strappazzon, Flavie, Dengjel, Joern, Fimia, Gian Maria, Cecconi, Francesco, and DI BARTOLOMEO, Sabrina

Published
2016

26. Characterization of three novel pathogenic SLC40A1 mutations and genotype/phenotype correlations in 7 Italian families with type 4 hereditary hemochromatosis

Author

Sabrina Di Bartolomeo, Marianna De Muro, Francesca Clementina Radio, Michele Valiante, Andrea Cortese, Fabio Polticelli, Carmelilia De Bernardo, Paola Grammatico, Giovanni Musci, Silvia Majore, Fiorella Faienza, Maria Carmela Bonaccorsi di Patti, Majore, Silvia, Bonaccorsi di Patti, Maria Carmela, Valiante, Michele, Polticelli, Fabio, Cortese, Andrea, Di Bartolomeo, Sabrina, De Bernardo, Carmelilia, De Muro, Marianna, Faienza, Fiorella, Radio, Francesca Clementina, Grammatico, Paola, and Musci, Giovanni

Subjects
Adult, Male, 0301 basic medicine, Adolescent, Hemochromatosi, Iron, Ferroportin, Molecular Conformation, Mutation, Missense, Biology, medicine.disease_cause, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Hepcidins, Hepcidin, medicine, Homeostasis, Humans, Missense mutation, hemochromatosis, iron, molecular medicine, molecular biology, Child, Cation Transport Proteins, Molecular Biology, Genetic Association Studies, Hemochromatosis, Loss function, Aged, Genes, Dominant, Family Health, Genetics, Mutation, Middle Aged, medicine.disease, Phenotype, HEK293 Cells, 030104 developmental biology, Italy, 030220 oncology & carcinogenesis, Hereditary hemochromatosis, Ferritins, biology.protein, Molecular Medicine, Female
Abstract

Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations. This disease can be classified as type 4A, better known as “ferroportin disease”, which is due to “loss of function” mutations that lead to decreased iron export from cells, or as type 4B hemochromatosis, which is caused by “gain of function” mutations, conferring partial or complete resistance to hepcidin-mediated Fpn degradation. In this work, we discuss clinical and molecular findings on a group of patients in whom a SLC40A1 single copy missense variant was identified. Three novel variants, p.D181N, p.G204R and p.R296Q were functionally characterized. Fpn D181N and R296Q mutants can be classified as full or partial loss of function, respectively. Replacement of G204 with arginine appears to cause a more complex defect with impact both on iron export function and hepcidin sensitivity. This finding confirms the difficulty of predicting the effect of a mutation on the molecular properties of Fpn in order to provide an exhaustive explanation to the wide variability of the phenotype in type 4 hereditary hemochromatosis.

Published
2018

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