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Co(II), Ni(II), Zn(II), and Cd(II) complexes were synthesized from a Schiff base ligand, benzyl-2-(1-(thiophen-2-yl)propylidene)hydrazine-1-carbodithioate (BTPHC), by conventional as well as microwave irradiation methods. The ligand and its metal complexes were characterized by spectroscopic techniques (FT-IR, UV-vis, mass spectrometry, and 1H NMR) and powder X-ray diffraction. Based on magnetic measurements and spectral data, octahedral environments for Co(II) and Ni(II) complexes and tetrahedral environments for Zn(II) and Cd(II) complexes are proposed. The metal(II) complexes were active toward bacterial and fungal strains. Antidiabetic studies showed that the Cd(II) complex possesses greater potential as an antidiabetic agent than the other metal complexes and the ligand. Antioxidant studies indicate that the Zn(II) and Cd(II) complexes possess high radical scavenging activities. The synthesized ligand and metal(II) complexes were screened for their anticancer properties against two human cancer cell lines MCF-7 and HeLa using an MTT cell viability assay. The Ni(II) complex excelled in halting the proliferation of HeLa and MCF-7 cancer cell lines with IC50 values of 46.63 µM and 80.90 µM, respectively, whereas it displayed insignificant cytotoxicity against the human normal embryonic kidney cell line (HEK293) with IC50 = 300.41 µM. [ABSTRACT FROM AUTHOR]

A series of mononuclear organoantimony(III) and organoarsenic(III) complexes of bidentate Schiff base [2-(2- fluorophenyl)methylene]hydrazinecarbothioamide (LH) have been synthesized by the reaction of Ph3Sb and Ph3As with ligand in 1:1 and 1:2 molar ratios. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combination of electronic, IR, ¹H NMR, 13C NMR and X-ray diffraction studies. These studies have shown that the ligand coordinated to the antimony and arsenic in a monobasic bidentate manner through sulfur and nitrogen donor system. Thus, a tetra-coordinated and a penta-coordinated environment around the antimony and arsenic atom have been proposed for 1:1 and 1:2 complexes, respectively. All the complexes and parent ligand have been screened for their antimicrobial activity on several pathogenic fungi and bacteria and are found to possess appreciable fungicidal and bactericidal properties. Further, the ligand and its corresponding metal complexes have been tested for their DNA cleavage activity by the gel electrophoresis and the results revealed that the complexes are better cleaving agents than ligand. [ABSTRACT FROM AUTHOR]