Search

Introduction: Pain management after hysterectomy is a critical concern, and limited studies have investigated the effect of LigaSure on postoperative pain. This study aimed to compare pain levels after Total Abdominal Hysterectomy (TAH) using traditional methods versus the LigaSure device. Methods: This registered clinical trial included 29 patients undergoing TAH at an institutional tertiary hospital in Tehran, Iran, from 2021 to 2023. 16 patients underwent TAH with traditional methods, and 13 with LigaSure. Data on pain intensity (6 hours and 24 hours post-surgery), analgesic consumption, intraoperative blood loss, hospitalization length, hemoglobin drop, and cancer surgery duration were collected through patient interviews and medical records. SPSS 26 and the Mann-Whitney U test were used for analysis (Registry ID: IRCT20221109056457N1). Results: Pain intensity at 6 hours and 24 hours post-surgery was significantly lower in the LigaSure group compared to the traditional method group (p<0.05). Surgery duration was also significantly shorter with LigaSure (p<0.05). No significant differences were found between the two groups in terms of analgesic consumption, intraoperative blood loss, hospitalization length, or hemoglobin drop (p>0.05). Conclusion: TAH with LigaSure significantly reduces postoperative pain and cancer surgery duration compared to traditional methods. This method is recommended for women undergoing hysterectomy. However, cancer multicenter clinical trials with larger sample sizes are needed to further evaluate its benefits and potential complications. [ABSTRACT FROM AUTHOR]

Introduction: Corticosteroids are prescribed to pregnant mothers for fetal lung maturation, but there is still much debate about their effects and side effects, complications arising from preterm birth and the high mortality rate in this group, and the conflicting results of similar studies, the need to investigate the effects of betamethasone administration in reducing postpartum complications in mothers with preterm labor at 34 weeks to 36 weeks of pregnancy. Therefore, this study aimed to find a 48 hour Expectant Management for these mothers to reduce these complications Materials and Methods: This study is an interventional and clinical trial. The target population consists of mothers with preterm labor at 34 weeks to 36 weeks of pregnancy and newborns born at Mahdieh Hospital in Tehran, Iran. Individuals were randomly assigned to two groups, control and intervention. The intervention group received betamethasone along with ampicillin until the end of pregnancy, and the control group received only ampicillin until the end of pregnancy. After delivery, the prevalence of respiratory distress syndrome, tachypnea, need for oxygen or surfactant, jaundice, hypoglycemia, and neonatal mortality, as well as maternal outcomes including wound infection, amount of bleeding, antibiotic use, chorioamnionitis, and duration of hospitalization with betamethasone in two groups were recorded and compared. Results: The mean age among mothers in the control group was 29.39 years and among mothers in the intervention group was 25.97 years, with this difference being significantly higher in mothers in the control group. Out of 100 mothers in the control group, 45 had cesarean deliveries and 56 had vaginal deliveries, with no significant difference between the two groups. None of the mothers in either group experienced complications such as wound infection, chorioamnionitis, postpartum fever, or atony. In the control group, out of 100 newborns, there were 45 girls and 56 boys, while in the intervention group, there were 44 girls and 56 boys. The mean Apgar score at 1 minute and 5 minutes did not show a significant difference between the two groups, although both the 1 minute and 5 minute Apgar scores were higher in the intervention group. Invasive ventilation and NICU hospitalization were higher in the control group than the intervention group, and non-invasive ventilation and surfactant injection were higher in the intervention group than the control group, but this difference was not significant. Only one newborn in the intervention group died due to cancer, and among other indicators, no significant differences were observed between the two groups in terms of duration of hospitalization and jaundice. Conclusion: Based on the results of the present study, a full course of betamethasone in mothers with preterm labor at 34 weeks to 36 weeks of pregnancy had no significant impact on pregnancy outcomes for the mother and fetus. None of the measured indicators in the study for infants showed a significant difference between the two intervention and control groups. [ABSTRACT FROM AUTHOR]