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The reactions of diphenylamine and benzoyl isothiocyanates with phenacyl bromide or methyl 2-bromoacetate in the presence of triethylamine yield 2,4,5-trisubstituted thiazole derivatives. The molecular structures of [2-(diphenylamino)-4-phenylthiazol-5-yl]( o-tolyl) methanone and methyl 4-(4-chlorophenyl)-2-(diphenylamino)thiazole-5-carboxylate have been fully determined by means of single crystal X-ray diffraction methods.

Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones catalyzed by imidazole or isoquinoline as organocatalyst via the condensation of aromatic aldehydes, dimedone, and β-naphthol was carried out under solvent-free conditions. This method provides several advantages such as short reaction time, environment friendliness, good yields, and simple work-up procedure. .

N-Phenacyl heterocyclic salts such as isoquinolinium, quinolinium, and pyridinium bromide react quickly with benzoyl isothiocyanate in the present of triethylamine to produce 1,4-diionic organosulfur derivatives. Cyclization and dehydrogenation of 1,4-diionic organosulfurs gave thiazoloisoquinolinium, quinolinium, or pyridinium benzimidates. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental files: Figures.].