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7 results on '"Fagioli, Stefano"'

1. Reduced Levels of ABCA1 Transporter Are Responsible for the Cholesterol Efflux Impairment in β-Amyloid-Induced Reactive Astrocytes: Potential Rescue from Biomimetic HDLs

Author

Sierri, Giulia, primary, Dal Magro, Roberta, additional, Vergani, Barbara, additional, Leone, Biagio Eugenio, additional, Formicola, Beatrice, additional, Taiarol, Lorenzo, additional, Fagioli, Stefano, additional, Kravicz, Marcelo, additional, Tremolizzo, Lucio, additional, Calabresi, Laura, additional, and Re, Francesca, additional

Published
2021
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3. Oxidative Stress Boosts the Uptake of Cerium Oxide Nanoparticles by Changing Brain Endothelium Microvilli Pattern

Author

Dal Magro, Roberta, primary, Vitali, Agostina, additional, Fagioli, Stefano, additional, Casu, Alberto, additional, Falqui, Andrea, additional, Formicola, Beatrice, additional, Taiarol, Lorenzo, additional, Cassina, Valeria, additional, Marrano, Claudia Adriana, additional, Mantegazza, Francesco, additional, Anselmi-Tamburini, Umberto, additional, Sommi, Patrizia, additional, and Re, Francesca, additional

Published
2021
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6. Incidence and clinical predictors of primary opportunistic deep cutaneous mycoses in solid organ transplant recipients: a multicenter cohort study

Author

Tessari, Gianpaolo, primary, Naldi, Luigi, additional, Piaserico, Stefano, additional, Boschiero, Luigino, additional, Nacchia, Francesco, additional, Forni, Alberto, additional, Rugiu, Carlo, additional, Faggian, Giuseppe, additional, Dall’Olio, Elena, additional, Fortina, Anna Belloni, additional, Alaibac, Mauro, additional, Sassi, Fabrizia, additional, Gotti, Eliana, additional, Fiocchi, Roberto, additional, Fagioli, Stefano, additional, and Girolomoni, Giampiero, additional

Published
2009
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7. Reduced Levels of ABCA1 Transporter Are Responsible for the Cholesterol Efflux Impairment in β-Amyloid-Induced Reactive Astrocytes: Potential Rescue from Biomimetic HDLs.

Author

Sierri, Giulia, Dal Magro, Roberta, Vergani, Barbara, Leone, Biagio Eugenio, Formicola, Beatrice, Taiarol, Lorenzo, Fagioli, Stefano, Kravicz, Marcelo, Tremolizzo, Lucio, Calabresi, Laura, and Re, Francesca

Subjects
ATP-binding cassette transporters, ASTROCYTES, CHOLESTEROL metabolism, BLOOD-brain barrier, LIPOPROTEINS, CHOLESTEROL, BLOOD cholesterol
Abstract

The cerebral synthesis of cholesterol is mainly handled by astrocytes, which are also responsible for apoproteins' synthesis and lipoproteins' assembly required for the cholesterol transport in the brain parenchyma. In Alzheimer disease (AD), these processes are impaired, likely because of the astrogliosis, a process characterized by morphological and functional changes in astrocytes. Several ATP-binding cassette transporters expressed by brain cells are involved in the formation of nascent discoidal lipoproteins, but the effect of beta-amyloid (Aβ) assemblies on this process is not fully understood. In this study, we investigated how of Aβ1-42-induced astrogliosis affects the metabolism of cholesterol in vitro. We detected an impairment in the cholesterol efflux of reactive astrocytes attributable to reduced levels of ABCA1 transporters that could explain the decreased lipoproteins' levels detected in AD patients. To approach this issue, we designed biomimetic HDLs and evaluated their performance as cholesterol acceptors. The results demonstrated the ability of apoA-I nanodiscs to cross the blood–brain barrier in vitro and to promote the cholesterol efflux from astrocytes, making them suitable as a potential supportive treatment for AD to compensate the depletion of cerebral HDLs. [ABSTRACT FROM AUTHOR]

Published
2022
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