Search

Your search keyword '"Faghih R"' showing total 149 results
Start Over Author "Faghih R"
149 results on '"Faghih R"'

1. External Periodic Driving of Large Systems of Globally Coupled Phase Oscillators

Author

Antonsen Jr., T. M., Faghih, R. T., Girvan, M., Ott, E., and Platig, J.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

Large systems of coupled oscillators subjected to a periodic external drive occur in many situations in physics and biology. Here the simple, paradigmatic case of equal-strength, all-to-all sine-coupling of phase oscillators subject to a sinusoidal external drive is considered. The stationary states and their stability are determined. Using the stability information and numerical experiments, parameter space phase diagrams showing when different types of system behavior apply are constructed, and the bifurcations marking transitions between different types of behavior are delineated. The analysis is supported by results of direct numerical simulation of an ensemble of oscillators.

Published
2007
Full Text
View/download PDF

2. Effect of different dietary levels of plant protein on growth indexes of White Leg shrimp

Author

R. Ghorbani; A. Matinfar; N. Samani; Gh. Faghih; R. Ghorbani

Subjects
plant, treatment, protein, Agriculture, Aquaculture. Fisheries. Angling, SH1-691
Abstract

The influence of different dietary levels of plant protein (30, 50 and 70%) on growth indices of White Leg Shrimp (Litopenaeus vannamei) fed with an original 38 percent protein was assessed and compared with that of the commercial shrimp diet. The average weight gain at the end of the culture period in treatment 1 (30% plant protein and 70% animal protein), was 5.89 plus or minus 0.06 grams, for treatment 2 (50% plant protein and 50% animal protein), was 6.22 plus or minus 0.25 grams, for treatment 3 (70% plant protein and 30% animal protein), was 6.19 plus or minus 0.24 grams and for the control treatment (20% plant protein and 80% animal protein), was 6.42 plus or minus 0.40 grams. Our study of the influence of experimental and control diets on growth indices including growth rate (GR), food conversion ratio (FCR), protein efficiency ratio (PER), specific growth rate (SGR), and average daily gain (ADG), demonstrated that the indices were better in the control compared to the treatmen.....

Published
2009

8. 2. Histaminergic mechanisms in the CNS

Author

Fox, G. B., Esbenshade, T. A., Pan, J. B., Browman, K. E., Zhang, M., Ballard, M. E., Radek, R. J., Miner, H., Bitner, R. S., Krueger, K. M., Yao, B. B., Faghih, R., Rueter, L. E., Komater, V. A., Drescher, K. U., Buckley, M. J., Sullivan, J. P., Cowart, M. D., Decker, M. W., and Hancock, A. A.

Published
2005
Full Text
View/download PDF

24. The medicinal chemistry of novel H 3 antagonists

Author

Cowart, M., primary, Faghih, R., additional, Gfesser, G., additional, Curtis, M., additional, Pratt, J. K., additional, Bennani, Y., additional, Fox, G. B., additional, Esbenshade, T. A., additional, and Hancock, A. A., additional

Published
2004
Full Text
View/download PDF

34. Synthesis and SAR of 5-Amino- and 5-(Aminomethyl)benzofuran Histamine H<INF>3</INF> Receptor Antagonists with Improved Potency

Author

Sun, M., Zhao, C., Gfesser, G. A., Thiffault, C., Miller, T. R., Marsh, K., Wetter, J., Curtis, M., Faghih, R., Esbenshade, T. A., Hancock, A. A., and Cowart, M.

Abstract

A new series of H3 receptor antagonists was discovered with nanomolar and subnanomolar affinities at human and rat H3 receptors. Starting from an earlier, more structurally limited series of benzofurans, the present series of compounds demonstrated increased structural variety and flexibility with greater in vitro potency. One compound in particular, {2-[2-(2-(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl}(5-nitropyridin-2-yl)amine (7h), gave the best binding potency (human Ki of 0.05 nM, rat Ki of 0.11 nM), which represented a 9-fold (in human) and an 11-fold (in rat) improvement over ABT-239 (compound 5), a compound previously reported to have excellent in vitro potency and in vivo efficacy. The synthesis, SAR of the H3 binding affinities, in vitro assay for phospholipidosis, and pharmacokinetic properties of the new compounds are described.

Published
2005

35. 4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H<INF>3</INF> Receptor Antagonists Potently Enhance Cognition and Attention

Author

Cowart, M., Faghih, R., Curtis, M. P., Gfesser, G. A., Bennani, Y. L., Black, L. A., Pan, L., Marsh, K. C., Sullivan, J. P., Esbenshade, T. A., Fox, G. B., and Hancock, A. A.

Abstract

H3 receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and rat H3 receptors, with Ki values of 0.1−5.8 nM. Analogues were discovered with potent (0.01−1 mg/kg) cognition and attention enhancing properties in animal models. One compound in particular, 4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile (ABT-239), combined potent and selective H3 receptor antagonism and excellent pharmacokinetic and metabolic properties across species, with full efficacy in two behavioral models:  a five-trial inhibitory avoidance acquisition model in rat pups at 0.1 mg/kg and a social recognition memory model in adult rats at 0.01 mg/kg. Furthermore, this compound did not stimulate locomotor activity and showed high selectivity for the induction of behavioral efficacy versus central nervous system based side effects. The potency and selectivity of this compound and of analogues from this class support the potential of H3 receptor antagonists for the treatment of cognitive dysfunction.

Published
2005

38. Synthesis and Structure−Activity Relationships of 2-Pyridones:  A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents

Author

Li, Q., Chu, D. T. W., Claiborne, A., Cooper, C. S., Lee, C. M., Raye, K., Berst, K. B., Donner, P., Wang, W., Hasvold, L., Fung, A., Ma, Z., Tufano, M., Flamm, R., Shen, L. L., Baranowski, J., Nilius, A., Alder, J., Meulbroek, J., Marsh, K., Crowell, D., Hui, Y., Seif, L., Melcher, L. M., Henry, R., Spanton, S., Faghih, R., Klein, L. L., Tanaka, S. K., and Plattner, J. J.

Abstract

Two novel series of 2-pyridones were synthesized by transposition of the nitrogen of 4-quinolones to the bridgehead position. This subtle interchange of the nitrogen atom with a carbon atom yielded two novel heterocyclic nuclei, pyrido[1,2-a]pyrimidine and quinolizine, which had not previously been evaluated as antibacterial agents and were found to be potent inhibitors of DNA gyrase. Quinolizines with a methyl group at the 9-position such as (S)-45a (ABT-719) demonstrate exceptional broad spectrum antibacterial activity. Most notably, they are active against resistant bacteria such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant strains of enterococci, and ciprofloxacin-resistant organisms. In addition, 2-pyridones also possess favorable physiochemical and pharmacokinetic properties. These 2-pyridones were synthesized from the commercially available starting materials by 10−17 linear transformations. The structure of an adduct yielded by this sequence, (S)-45a (ABT-719), was determined by X-ray crystallographic analysis.

Published
1996

39. Synthesis of 9-Deoxo-4‘‘-deoxy-6,9-epoxyerythromycin Derivatives:  Novel and Acid-Stable Motilides

Author

Faghih, R., Lartey, P. A., Nellans, H. N., Seif, L., Burnell-Curty, C., Klein, L. L., Thomas, P., Petersen, A., Borre, A., Pagano, T., Kim, K. H., Heindel, M., Bennani, Y. L., and Plattner, J. J.

Abstract

In our quest toward the discovery of highly potent and acid-stable motilides, novel 4‘‘-deoxy derivatives of 9-deoxo-6,9-epoxyerythromycin were designed, synthesized, and evaluated for their gastrointestinal prokinetic activities. These compounds, in their 9R configuration, were more potent than their 6,9-enol ether homologues in inducing well-coordinated smooth muscle contractions in an in vitro rabbit duodenal assay:  e.g., (9R),(8S)-9-deoxo-4‘‘-deoxy-3‘-N-desmethyl-3‘-N-ethyl-6,9-epoxyerythromycin A (10) and (9R),(8S)-9-deoxo-4‘‘-deoxy-3‘-N-desmethyl-3‘-N-ethanol-6,9-epoxyerythromycin A (15) had a pED50 of 8.54 and 8.11 compared to a pED50 of 7.22 for compound 2 (ABT-229). Reduction of the 6,9-enol ether, which was aimed at improving the acid stability, afforded the most stable motilides to date with t1/2 of 5.5 h for 10 and 15. Compounds 10 and 15 bind specifically to rabbit antral smooth muscle motilin receptors with pIC50 values of 8.52 and 8.70.

Published
1998

Catalog

Books, media, physical & digital resources
See catalog results