Author: "Faggian, Alessia" - Searchworks@Jio Institute Digital Library Search Results

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43 results on '"Faggian, Alessia"'

1. Kauffman Model with Spatially Separated Ligation and Cleavage Reactions

Author: Schneider, Johannes Josef, Eggenberger Hotz, Peter, Jamieson, William David, Faggian, Alessia, Li, Jin, Matuttis, Hans-Georg, Caliari, Adriano, Weyland, Mathias Sebastian, Flumini, Dandolo, Diaz, Aitor Patiño, Holler, Silvia, Casiraghi, Federica, Cebolla Sanahuja, Lorena, Hanczyc, Martin Michael, Barrow, David Anthony, Dimitriou, Pantelitsa, Castell, Oliver, Füchslin, Rudolf Marcel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Villani, Marco, editor, Cagnoni, Stefano, editor, and Serra, Roberto, editor
Published: 2024
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2. Percolation Breakdown in Binary and Ternary Monodisperse and Polydisperse Systems of Spherical Particles

Author: Schneider, Johannes Josef, Faggian, Alessia, Weyland, Mathias Sebastian, Jamieson, William David, Li, Jin, Matuttis, Hans-Georg, Holler, Silvia, Casiraghi, Federica, Diaz, Aitor Patiño, Cebolla Sanahuja, Lorena, Hanczyc, Martin Michael, Flumini, Dandolo, Eggenberger Hotz, Peter, Barrow, David Anthony, Dimitriou, Pantelitsa, Castell, Oliver, Füchslin, Rudolf Marcel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Villani, Marco, editor, Cagnoni, Stefano, editor, and Serra, Roberto, editor
Published: 2024
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3. GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Author: Lagou, Vasiliki, Jiang, Longda, Ulrich, Anna, Zudina, Liudmila, González, Karla Sofia Gutiérrez, Balkhiyarova, Zhanna, Faggian, Alessia, Maina, Jared G., Chen, Shiqian, Todorov, Petar V., Sharapov, Sodbo, David, Alessia, Marullo, Letizia, Mägi, Reedik, Rujan, Roxana-Maria, Ahlqvist, Emma, Thorleifsson, Gudmar, Gao, Ηe, Εvangelou, Εvangelos, Benyamin, Beben, Scott, Robert A., Isaacs, Aaron, Zhao, Jing Hua, Willems, Sara M., Johnson, Toby, Gieger, Christian, Grallert, Harald, Meisinger, Christa, Müller-Nurasyid, Martina, Strawbridge, Rona J., Goel, Anuj, Rybin, Denis, Albrecht, Eva, Jackson, Anne U., Stringham, Heather M., Corrêa, Jr., Ivan R., Farber-Eger, Eric, Steinthorsdottir, Valgerdur, Uitterlinden, André G., Munroe, Patricia B., Brown, Morris J., Schmidberger, Julian, Holmen, Oddgeir, Thorand, Barbara, Hveem, Kristian, Wilsgaard, Tom, Mohlke, Karen L., Wang, Zhe, Shmeliov, Aleksey, den Hoed, Marcel, Loos, Ruth J. F., Kratzer, Wolfgang, Haenle, Mark, Koenig, Wolfgang, Boehm, Bernhard O., Tan, Tricia M., Tomas, Alejandra, Salem, Victoria, Barroso, Inês, Tuomilehto, Jaakko, Boehnke, Michael, Florez, Jose C., Hamsten, Anders, Watkins, Hugh, Njølstad, Inger, Wichmann, H.-Erich, Caulfield, Mark J., Khaw, Kay-Tee, van Duijn, Cornelia M., Hofman, Albert, Wareham, Nicholas J., Langenberg, Claudia, Whitfield, John B., Martin, Nicholas G., Montgomery, Grant, Scapoli, Chiara, Tzoulaki, Ioanna, Elliott, Paul, Thorsteinsdottir, Unnur, Stefansson, Kari, Brittain, Evan L., McCarthy, Mark I., Froguel, Philippe, Sexton, Patrick M., Wootten, Denise, Groop, Leif, Dupuis, Josée, Meigs, James B., Deganutti, Giuseppe, Demirkan, Ayse, Pers, Tune H., Reynolds, Christopher A., Aulchenko, Yurii S., Kaakinen, Marika A., Jones, Ben, and Prokopenko, Inga
Published: 2023
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4. Network Creation During Agglomeration Processes of Polydisperse and Monodisperse Systems of Droplets

Author: Schneider, Johannes Josef, Faggian, Alessia, Diaz, Aitor Patiño, Li, Jin, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David Anthony, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, Dimitriou, Pantelitsa, Jamieson, William David, Castell, Oliver, Eschle, Patrik, Füchslin, Rudolf Marcel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, De Stefano, Claudio, editor, Fontanella, Francesco, editor, and Vanneschi, Leonardo, editor
Published: 2023
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5. Computational Investigation of the Clustering of Droplets in Widening Pipe Geometries

Author: Matuttis, Hans-Georg, Schneider, Johannes Josef, Li, Jin, Barrow, David Anthony, Faggian, Alessia, Diaz, Aitor Patiño, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Weyland, Mathias Sebastian, Flumini, Dandolo, Hotz, Peter Eggenberger, Dimitriou, Pantelitsa, Jamieson, William David, Castell, Oliver, Füchslin, Rudolf Marcel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, De Stefano, Claudio, editor, Fontanella, Francesco, editor, and Vanneschi, Leonardo, editor
Published: 2023
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6. Artificial Chemistry Performed in an Agglomeration of Droplets with Restricted Molecule Transfer

Author: Schneider, Johannes Josef, Faggian, Alessia, Jamieson, William David, Weyland, Mathias Sebastian, Li, Jin, Castell, Oliver, Matuttis, Hans-Georg, Barrow, David Anthony, Diaz, Aitor Patiño, Sanahuja, Lorena Cebolla, Holler, Silvia, Casiraghi, Federica, Hanczyc, Martin Michael, Flumini, Dandolo, Eggenberger Hotz, Peter, Füchslin, Rudolf Marcel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, De Stefano, Claudio, editor, Fontanella, Francesco, editor, and Vanneschi, Leonardo, editor
Published: 2023
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7. Ethical Aspects of Computational Modelling in Science, Decision Support and Communication

Author: Füchslin, Rudolf Marcel, Ambühl, Jacques, Faggian, Alessia, Fellermann, Harold M., Flumini, Dandolo, Geller, Armando, Hanczyc, Martin M., Klinkert, Andreas, Krütli, Pius, Matuttis, Hans-Georg, Ott, Thomas, Scheidegger, Stephan, Schmid, Gary Bruno, Smieszek, Timo, Schneider, Johannes J., Steiner, Albert, Weyland, Mathias S., Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Schneider, Johannes Josef, editor, Weyland, Mathias Sebastian, editor, Flumini, Dandolo, editor, and Füchslin, Rudolf Marcel, editor
Published: 2022
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8. The Good, the Bad and the Ugly: Droplet Recognition by a 'Shootout'-Heuristics

Author: Matuttis, Hans-Georg, Holler, Silvia, Casiraghi, Federica, Schneider, Johannes Josef, Faggian, Alessia, Füchslin, Rudolf Marcel, Hanczyc, Martin Michael, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Schneider, Johannes Josef, editor, Weyland, Mathias Sebastian, editor, Flumini, Dandolo, editor, and Füchslin, Rudolf Marcel, editor
Published: 2022
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9. Obstacles on the Pathway Towards Chemical Programmability Using Agglomerations of Droplets

Author: Schneider, Johannes Josef, Faggian, Alessia, Matuttis, Hans-Georg, Barrow, David Anthony, Li, Jin, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Eschle, Patrik, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, Füchslin, Rudolf Marcel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Schneider, Johannes Josef, editor, Weyland, Mathias Sebastian, editor, Flumini, Dandolo, editor, and Füchslin, Rudolf Marcel, editor
Published: 2022
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10. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author: Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke- Jan, Grallert, Harald, Perry, John R. B., Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L., Dimas, Antigone S., Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R., Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G., Isaacs, Aaron, Willems, Sara M., Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U., Montasser, May E., O’Connell, Jeff R., Bielak, Lawrence F., Webster, Rebecca J., Saxena, Richa, Stafford, Jeanette M., Pourcain, Beate St, Timpson, Nicholas J., Salo, Perttu, Shin, So-Youn, Amin, Najaf, Smith, Albert V., Li, Guo, Verweij, Niek, Goel, Anuj, Ford, Ian, Johnson, Paul C. D., Johnson, Toby, Kapur, Karen, Thorleifsson, Gudmar, Strawbridge, Rona J., Rasmussen-Torvik, Laura J., Esko, Tõnu, Mihailov, Evelin, Fall, Tove, Fraser, Ross M., Mahajan, Anubha, Kanoni, Stavroula, Giedraitis, Vilmantas, Kleber, Marcus E., Silbernagel, Günther, Meyer, Julia, Müller-Nurasyid, Martina, Ganna, Andrea, Sarin, Antti-Pekka, Yengo, Loic, Shungin, Dmitry, Luan, Jian’an, Horikoshi, Momoko, An, Ping, Sanna, Serena, Boettcher, Yvonne, Rayner, N. William, Nolte, Ilja M., Zemunik, Tatijana, Iperen, Erik van, Kovacs, Peter, Hastie, Nicholas D., Wild, Sarah H., McLachlan, Stela, Campbell, Susan, Polasek, Ozren, Carlson, Olga, Egan, Josephine, Kiess, Wieland, Willemsen, Gonneke, Kuusisto, Johanna, Laakso, Markku, Dimitriou, Maria, Hicks, Andrew A., Rauramaa, Rainer, Bandinelli, Stefania, Thorand, Barbara, Liu, Yongmei, Miljkovic, Iva, Lind, Lars, Doney, Alex, Perola, Markus, Hingorani, Aroon, Kivimaki, Mika, Kumari, Meena, Bennett, Amanda J., Groves, Christopher J., Herder, Christian, Koistinen, Heikki A., Kinnunen, Leena, Faire, Ulf de, Bakker, Stephan J. L., Uusitupa, Matti, Palmer, Colin N. A., Jukema, J. Wouter, Sattar, Naveed, Pouta, Anneli, Snieder, Harold, Boerwinkle, Eric, Pankow, James S., Magnusson, Patrik K., Krus, Ulrika, Scapoli, Chiara, de Geus, Eco J. C. N., Blüher, Matthias, Wolffenbuttel, Bruce H. R., Province, Michael A., Abecasis, Goncalo R., Meigs, James B., Hovingh, G. Kees, Lindström, Jaana, Wilson, James F., Wright, Alan F., Dedoussis, George V., Bornstein, Stefan R., Schwarz, Peter E. H., Tönjes, Anke, Winkelmann, Bernhard R., Boehm, Bernhard O., März, Winfried, Metspalu, Andres, Price, Jackie F., Deloukas, Panos, Körner, Antje, Lakka, Timo A., Keinanen-Kiukaanniemi, Sirkka M., Saaristo, Timo E., Bergman, Richard N., Tuomilehto, Jaakko, Wareham, Nicholas J., Langenberg, Claudia, Männistö, Satu, Franks, Paul W., Hayward, Caroline, Vitart, Veronique, Kaprio, Jaakko, Visvikis-Siest, Sophie, Balkau, Beverley, Altshuler, David, Rudan, Igor, Stumvoll, Michael, Campbell, Harry, van Duijn, Cornelia M., Gieger, Christian, Illig, Thomas, Ferrucci, Luigi, Pedersen, Nancy L., Pramstaller, Peter P., Boehnke, Michael, Frayling, Timothy M., Shuldiner, Alan R., Peyser, Patricia A., Kardia, Sharon L. R., Palmer, Lyle J., Penninx, Brenda W., Meneton, Pierre, Harris, Tamara B., Navis, Gerjan, Harst, Pim van der, Smith, George Davey, Forouhi, Nita G., Loos, Ruth J. F., Salomaa, Veikko, Soranzo, Nicole, Boomsma, Dorret I., Groop, Leif, Tuomi, Tiinamaija, Hofman, Albert, Munroe, Patricia B., Gudnason, Vilmundur, Siscovick, David S., Watkins, Hugh, Lecoeur, Cecile, Vollenweider, Peter, Franco-Cereceda, Anders, Eriksson, Per, Jarvelin, Marjo-Riitta, Stefansson, Kari, Hamsten, Anders, Nicholson, George, Karpe, Fredrik, Dermitzakis, Emmanouil T., Lindgren, Cecilia M., McCarthy, Mark I., Froguel, Philippe, Kaakinen, Marika A., Lyssenko, Valeriya, Watanabe, Richard M., Ingelsson, Erik, Florez, Jose C., Dupuis, Josée, Barroso, Inês, Morris, Andrew P., and Prokopenko, Inga
Published: 2021
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11. Current and future biomarkers in gastric cancer

Author: Abbas, Muhammad, Faggian, Alessia, Sintali, Dahiru Nasiru, Khan, Ghulam Jilany, Naeem, Shagufta, Shi, Meiqi, and Dingding, Chen
Published: 2018
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12. A chemical compiler for the synthesis of branched oligomers on standardized chemical reaction structures

Author: Weyland, Mathias S., Flumini, Dandolo, Schneider, Johannes J., Faggian, Alessia, Patiño Diaz, Aitor, Füchslin, Rudolf Marcel, Weyland, Mathias S., Flumini, Dandolo, Schneider, Johannes J., Faggian, Alessia, Patiño Diaz, Aitor, and Füchslin, Rudolf Marcel
Abstract: This research paper presents a chemical compiler developed to find optimal configurations of a platform for synthesizing specific branched oligomers in an artificial chemistry, along with exemplary compiler output and benchmarks where the platform configuration suggested by the compiler is compared to other configurations in simulation. The compiler operates as a pipeline with two stages: labelling and optimization. The report explains the structure of the compiler target and its interpretation, followed by a code walk-through of the compiler stages with code snippets and examples. The compiler can be used as a code generator for reactions in a chemical simulator and to derive loading schemes for multilevel droplets. The results obtained in simulations suggest that the container system can efficiently optimize the yield of coupled reaction networks and that multi-level droplets can lead to significant improvements.
Published: 2023

13. Ethical aspects of computational modelling in science, decision support and communication

Author: Füchslin, Rudolf Marcel, Ambühl, Jacques, Faggian, Alessia, Fellermann, Harold M., Flumini, Dandolo, Geller, Armando, Hanczyc, Martin M., Klinkert, Andreas, Krütli, Pius, Matuttis, Hans-Georg, Ott, Thomas, Scheidegger, Stephan, Schmid, Gary Bruno, Smieszek, Timo, Schneider, Johannes J., Steiner, Albert, Weyland, Mathias S., Füchslin, Rudolf Marcel, Ambühl, Jacques, Faggian, Alessia, Fellermann, Harold M., Flumini, Dandolo, Geller, Armando, Hanczyc, Martin M., Klinkert, Andreas, Krütli, Pius, Matuttis, Hans-Georg, Ott, Thomas, Scheidegger, Stephan, Schmid, Gary Bruno, Smieszek, Timo, Schneider, Johannes J., Steiner, Albert, and Weyland, Mathias S.
Abstract: The development of data science, the increase of computational power, the availability of the internet infrastructure for data exchange and the urgency for an understanding of complex systems require a responsible and ethical use of computational models in science, communication and decision-making. Starting with a discussion of the width of different purposes of computational models, we first investigate the process of model construction as an interplay of theory and experimentation. We emphasise the different aspects of the tension between model variables and experimentally measurable observables. The resolution of this tension is a prerequisite for the responsible use of models and an instrumental part of using models in the scientific processes. We then discuss the impact of models and the responsibility that results from the fact that models support and may also guide experimentation. Further, we investigate the difference between computational modelling in an interdisciplinary science project and computational models as tools in transdisciplinary decision support. We regard the communication of model structures and modelling results as essential; however, this communication cannot happen in a technical manner, but model structures and modelling results must be translated into a “narrative.” We discuss the role of concepts from disciplines such as literary theory, communication science, and cultural studies and the potential gains that a broader approach can obtain. Considering concepts from the liberal arts, we conclude that there is, besides the responsibility of the model author, also a responsibility of the user/reader of the modelling results.
Published: 2023

14. Obstacles on the pathway towards chemical programmability using agglomerations of droplets

Author: Schneider, Johannes Josef, Faggian, Alessia, Matuttis, Hans-Georg, Barrow, David Anthony, Li, Jin, Holler, Silvia, Casiraghi, Federica, Cebolla Sanahuja, Lorena, Hanczyc, Martin Michael, Eschle, Patrik, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, Füchslin, Rudolf Marcel, Schneider, Johannes Josef, Faggian, Alessia, Matuttis, Hans-Georg, Barrow, David Anthony, Li, Jin, Holler, Silvia, Casiraghi, Federica, Cebolla Sanahuja, Lorena, Hanczyc, Martin Michael, Eschle, Patrik, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, and Füchslin, Rudolf Marcel
Abstract: We aim at planning and creating specific agglomerations of droplets to study synergic communication using these as programmable units. In this paper, we give an overview of preliminary obstacles for the various research issues, namely of how to create droplets, how to set up droplet agglomerations using DNA technology, how to prepare them for confocal microscopy, how to make a computer see droplets on photos, how to analyze networks of droplets, how to perform simulations mimicking experiments, and how to plan specific agglomerations of droplets.
Published: 2023

15. The good, the bad and the ugly : droplet recognition by a “shootout”-heuristics

Author: Matuttis, Hans-Georg, Holler, Silvia, Casiraghi, Federica, Schneider, Johannes Josef, Faggian, Alessia, Füchslin, Rudolf Marcel, Hanczyc, Martin Michael, Matuttis, Hans-Georg, Holler, Silvia, Casiraghi, Federica, Schneider, Johannes Josef, Faggian, Alessia, Füchslin, Rudolf Marcel, and Hanczyc, Martin Michael
Abstract: We explain how to optimize the image analysis of mixed clusters of red and green droplets in solvents with various degrees of sharpness, brightness, contrast and density. The circular Hough Transform is highly efficient for separated circles with reasonable background contrast, but not for large amounts of partially overlapping shapes, some of them blurred, as in the images of our dense droplet suspensions. We explain why standard approaches for image improvement fail and present a “shootout” approach, where already detected circles are masked, so that the removal of sharp outlines improves the relative optical quality of the remaining droplets. Nevertheless, for intrinsic reasons, there are limits to the accuracy of data which can be obtained on very dense clusters.
Published: 2023

16. A Chemical Compiler for the Synthesis of Branched Oligomers on Standardized Chemical Reaction Structures

Author: Weyland, Mathias S., primary, Flumini, Dandolo, additional, Schneider, Johannes J., additional, Faggian, Alessia, additional, Diaz, Aitor Patiño, additional, and Füchslin, Rudolf M., additional
Published: 2023
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17. z-stack videos

Author: Faggian, Alessia
Abstract: video of the z-stack frames of some red+green populations assemblies
Published: 2022
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18. Paths in a network of polydisperse spherical droplets

Author: Schneider, Johannes Josef, Faggian, Alessia, Holler, Silvia, Casiraghi, Federica, Li, Jin, Sanahuja, Lorena Cebolla, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David Anthony, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, Eschle, Patrik, Patiño Diaz, Aitor, Füchslin, Rudolf Marcel, Schneider, Johannes Josef, Faggian, Alessia, Holler, Silvia, Casiraghi, Federica, Li, Jin, Sanahuja, Lorena Cebolla, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David Anthony, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, Eschle, Patrik, Patiño Diaz, Aitor, and Füchslin, Rudolf Marcel
Abstract: We simulate the movement and agglomeration of oil droplets in water under constraints, like confinement, using a simplified stochastic-hydrodynamic model. In the analysis of the network created by the droplets in the agglomeration, we focus on the paths between pairs of droplets and compare the computational results for various system sizes.
Published: 2022

19. Paths in a Network of Polydisperse Spherical Droplets

Author: Schneider, Johannes Josef, primary, Faggian, Alessia, additional, Holler, Silvia, additional, Casiraghi, Federica, additional, Li, Jin, additional, Sanahuja, Lorena Cebolla, additional, Matuttis, Hans-Georg, additional, Hanczyc, Martin Michael, additional, Barrow, David Anthony, additional, Weyland, Mathias Sebastian, additional, Flumini, Dandolo, additional, Hotz, Peter Eggenberger, additional, Eschle, Patrik, additional, Diaz, Aitor Patiño, additional, and Füchslin, Rudolf Marcel, additional
Published: 2022
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20. Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author: Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke-Jan, Grallert, Harald, Perry, John R B, Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L, Dimas, Antigone S, Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R, Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G, Isaacs, Aaron, Willems, Sara M, Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U, Montasser, May E, O'Connell, Jeff R, Bielak, Lawrence F, Webster, Rebecca J, Saxena, Richa, Stafford, Jeanette M, et al, and University of Zurich
Subjects: 1300 General Biochemistry, Genetics and Molecular Biology, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 1600 General Chemistry, 3100 General Physics and Astronomy
Published: 2021

21. Influence of the geometry on the agglomeration of a polydisperse binary system of spherical particles

Author: Schneider, Johannes Josef, Faggian, Alessia, Holler, Silvia, Casiraghi, Federica, Li, Jin, Cebolla Sanahuja, Lorena, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David Anthony, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, Füchslin, Rudolf Marcel, Schneider, Johannes Josef, Faggian, Alessia, Holler, Silvia, Casiraghi, Federica, Li, Jin, Cebolla Sanahuja, Lorena, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David Anthony, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, and Füchslin, Rudolf Marcel
Published: 2021

22. Introduction to the generation and analysis of networks of droplets : lecture at the ACDC Summer School, online, 27 August 2021

Author: Faggian, Alessia, Schneider, Johannes Josef, Faggian, Alessia, and Schneider, Johannes Josef
Published: 2021

23. In vitro chronic glycation induces AGEs accumulation reducing insulin-stimulated glucose uptake and increasing GLP1R in adipocytes

Author: Chilelli, Nino-Cristiano, primary, Faggian, Alessia, additional, Favaretto, Francesca, additional, Milan, Gabriella, additional, Compagnin, Chiara, additional, Dassie, Francesca, additional, Bettini, Silvia, additional, Roverso, Marco, additional, Seraglia, Roberta, additional, Lapolla, Annunziata, additional, and Vettor, Roberto, additional
Published: 2021
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24. Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification

Author: Lagou, Vasiliki, primary, Jiang, Longda, additional, Ulrich, Anna, additional, Zudina, Liudmila, additional, González, Karla Sofia Gutiérrez, additional, Balkhiyarova, Zhanna, additional, Faggian, Alessia, additional, Chen, Shiqian, additional, Todorov, Petar, additional, Sharapov, Sodbo, additional, David, Alessia, additional, Marullo, Letizia, additional, Mägi, Reedik, additional, Rujan, Roxana-Maria, additional, Ahlqvist, Emma, additional, Thorleifsson, Gudmar, additional, Gao, He, additional, Evangelou, Evangelos, additional, Benyamin, Beben, additional, Scott, Robert, additional, Isaacs, Aaron, additional, Zhao, Jing Hua, additional, Willems, Sara M, additional, Johnson, Toby, additional, Gieger, Christian, additional, Grallert, Harald, additional, Meisinger, Christa, additional, Müller-Nurasyid, Martina, additional, Strawbridge, Rona J, additional, Goel, Anuj, additional, Rybin, Denis, additional, Albrecht, Eva, additional, Jackson, Anne U, additional, Stringham, Heather M, additional, Corrêa, Ivan R, additional, Eric, Farber-Eber, additional, Steinthorsdottir, Valgerdur, additional, Uitterlinden, André G, additional, Munroe, Patricia B, additional, Brown, Morris J, additional, Julian, Schmidberger, additional, Holmen, Oddgeir, additional, Thorand, Barbara, additional, Hveem, Kristian, additional, Wilsgaard, Tom, additional, Mohlke, Karen L, additional, Kratzer, Wolfgang, additional, Mark, Haenle, additional, Koenig, Wolfgang, additional, Boehm, Bernhard O, additional, Tan, Tricia M, additional, Tomas, Alejandra, additional, Salem, Victoria, additional, Barroso, Inês, additional, Tuomilehto, Jaakko, additional, Boehnke, Michael, additional, Florez, Jose C, additional, Hamsten, Anders, additional, Watkins, Hugh, additional, Njølstad, Inger, additional, Wichmann, H-Erich, additional, Caulfield, Mark J, additional, Khaw, Kay-Tee, additional, van Duijn, Cornelia, additional, Hofman, Albert, additional, Wareham, Nicholas J, additional, Langenberg, Claudia, additional, Whitfield, John B, additional, Martin, Nicholas G, additional, Montgomery, Grant, additional, Scapoli, Chiara, additional, Tzoulaki, Ioanna, additional, Elliott, Paul, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Brittain, Evan L, additional, McCarthy, Mark I, additional, Froguel, Philippe, additional, Sexton, Patrick M, additional, Wootten, Denise, additional, Groop, Leif, additional, Dupuis, Josée, additional, Meigs, James B, additional, Deganutti, Giuseppe, additional, Demirkan, Ayse, additional, Pers, Tune H, additional, Reynolds, Christopher A, additional, Aulchenko, Yurii S, additional, Kaakinen, Marika A, additional, Jones, Ben, additional, and Prokopenko, Inga, additional
Published: 2021
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25. In Vitro Effects of Low Doses of β-Caryophyllene, Ascorbic Acid and d-Glucosamine on Human Chondrocyte Viability and Inflammation

Author: Mattiuzzo, Elena, primary, Faggian, Alessia, additional, Venerando, Rina, additional, Benetti, Andrea, additional, Belluzzi, Elisa, additional, Abatangelo, Giovanni, additional, Ruggieri, Pietro, additional, and Brun, Paola, additional
Published: 2021
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26. Influence of the geometry on the agglomeration of a polydisperse binary system of spherical particles

Author: Schneider, Johannes Josef, primary, Faggian, Alessia, additional, Holler, Silvia, additional, Casiraghi, Federica, additional, Li, Jin, additional, Sanahuja, Lorena Cebolla, additional, Matuttis, Hans-Georg, additional, Hanczyc, Martin Michael, additional, Barrow, David Anthony, additional, Weyland, Mathias Sebastian, additional, Flumini, Dandolo, additional, Hotz, Peter Eggenberger, additional, and Füchslin, Rudolf Marcel, additional
Published: 2021
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27. The Viability and Anti-Inflammatory Effects of Hyaluronic Acid-Chitlac-Tracimolone Acetonide- β-Cyclodextrin Complex on Human Chondrocytes

Author: Tarricone, Elena, primary, Elia, Rossella, additional, Mattiuzzo, Elena, additional, Faggian, Alessia, additional, Pozzuoli, Assunta, additional, Ruggieri, Pietro, additional, and Brun, Paola, additional
Published: 2020
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28. The Viability and Anti-Inflammatory Effects of Hyaluronic Acid-Chitlac-Tracimolone Acetonide- β-Cyclodextrin Complex on Human Chondrocytes

Author: Tarricone, Elena, Elia, Rossella, Mattiuzzo, Elena, Faggian, Alessia, Pozzuoli, Assunta, Ruggieri, Pietro, and Brun, Paola
Abstract: Objective To compare the effects of the complex triamcinolone acetonide-hydroxypropyl-β-cyclodextrin (TA-CD) on in vitroinflamed primary human articular chondrocytes in the presence or absence of the mixture hyaluronic acid-Chitlac, a lactose-modified chitosan (HA-CTL).Design Changes in cell viability and pro-inflammatory cytokines gene expression were analyzed in human chondrocytes using an in vitromodel of macrophage-mediated inflammation. Human monocytes U937 were differentiated to macrophages by phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharides (LPS). The anti-inflammatory effects of the complex TA-CD and HA-CTL mixture were assessed on chondrocytes exposed for 24 hours to U937 conditioned medium (CM), by quantitative polymerase chain reaction analysis.Results The TA-CD viability was enhanced by the presence of the HA-CTL mixture in chondrocyte cultures. The exposure of cells to CM significantly increased interleukin-1β and interleukin-6 gene expression, and when the complex TA-CD was added to the inflamed cells, gene transcription of cytokines was restored to near baseline values, both in the presence or in the absence of HA-CTL mixture.Conclusion The addition of HA-CTL mixture significantly attenuated cytotoxicity induced by TA and preserved the anti-inflammatory effects, thus confirming the chondroprotective role of the HA-CTL mixture.
Published: 2021
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29. Glucotoxicity, Protein Glycation and Adipose Tissue Dysfunction

Author: Faggian, Alessia
Subjects: glucotoxicity, protein, glycation, adipose tisse, dysfunction, AGEs, RAGE, mass spectrometry, DPP4, diabetes glycation-inducing-environment, glucotossicità, glicazione, tessuto adiposo, obesità, obesity, GLP1R, diabetes glycation-inducing-environment, obesity, dysfunction, glicazione, MED/13 Endocrinologia, DPP4, AGEs, RAGE, obesità, Settore MED/13 - Endocrinologia, adipose tisse, glucotoxicity, tessuto adiposo, glycation, GLP1R, protein, glucotossicità, mass spectrometry
Abstract: Introduction: Glycation is a non-enzymatic reaction between a sugar and a free-amino group contained in molecules such as proteins, amino acids, DNA, RNA, and lipids. In the initial phase, the carbonyl group of the reducing carbohydrate condenses with the free-amino group on the biomolecule to form a reversible glycosylamine, which is then converted to a more stable Amadori product. Once formed, these products can with time undergo to dehydration, cyclization, oxidation, and rearrangements forming a polymorphic group of compounds collectively referred as Advanced Glycation End-products (AGEs). The accumulation of AGEs in vivo is considered the most important link between diabetes and oxidative disease. The rate of glycation could account for the long-term diabetic complications. Nevertheless, the role of AGEs is yet to be determined and it is, still nowadays, an important and challenging field of study. Little is known about their presence and their consequences on adipose tissue; in particular, the role of AGEs on adipogenesis and fat cell functionality remains fully unexplored. Methods: In this project, 3T3-L1 cell line and stromal vascular fraction cells isolated from human adipose tissue were used. The purpose was to set up an in vitro model for investigating the effects of a chronic exposure to a glycation-inducing environment on the adipogenetic process. Morphological analyses, E.L.I.S.A. assay for AGEs, expression analysis of lipid and glucose metabolism genes, glucose uptake, and immunofluorescence for RAGE, GLP1r, GLUT4 and AGEs, were performed on mature adipocytes. Moreover, the gene expression profile obtained in vitro, was compared to that of subcutaneous and visceral adipose tissues obtained from 64 obese subjects with type 2 diabetes or with normal glucose tolerance underwent to bariatric surgery. In collaboration with the Mass Spectrometry Service (CNR – IENI Padova), the use of mass spectrometry to characterize post-translation modifications induced by glycation was evaluated. Results and conclusions: Following an exposition to a glycation-inducing environment, an increase of intracellular AGEs both by immunofluorescence and E.L.I.S.A. was observed in our in vitro model. Preliminary analysis on cell cultures suggested that a glycation-inducing environment importantly impacts on gene expression profile. In glycating conditions, an increased expression of Glut4 and, on the contrary, an insulin-induced glucose uptake reduction was observed. These results allow us to hypothesize an influence of AGEs on GLUT4 translocation to the plasma-membrane and/or on its functionality. Finally, although mass spectrometry represents a high potential technique was shown that it has several disadvantages and technical challenges. In particular, several post-translational modifications can affect simultaneously the same protein, thus the total mass increase will reflect the sum of all modifications. Furthermore, spectra analysis of a whole cellular or tissue lysates resulted excessively complex to underline small differences. Multiple steps in which proteins of a specific molecular weight range would be isolated, concentrated and separately assayed are therefore required in order to simplify the analysis by mass spectrometry.
Published: 2016

30. Evaluation of the β-Caryophyllene effects alone or in combination with Ascorbic Acid and d-Glucosamine on inflamed Human Chondrocytes.

Author: Belluzzi, Elisa, Mattiuzzo, Elena, Faggian, Alessia, Venerando, Rina, Benetti, Andrea, Ruggieri, Pietro, and Brun, Paola
Subjects: CARTILAGE cells, VITAMIN C, EXTRACELLULAR matrix, ARTICULAR cartilage, INFLAMMATORY mediators, STAINS & staining (Microscopy), FIBRONECTINS, MONOCYTES
Abstract: Background: Osteoarthritis (OA) is a disabling disease affecting all joint tissues and particularly articular cartilage. Moreover, inflammatory process and mediators plays an important role in the initiation and progression of OA determining cartilage extracellular matrix degradation. Aim: The aim of this study is to evaluate the effects of β-caryophyllene (BCP), a plantderived sesquiterpene with anti-inflammatory and antioxidant properties, alone or in combination with ascorbic acid (AA) and d-glucosamine (GlcN) on human primary chondrocytes inflamed with macrophage-derived conditioned medium (CM). Materials and Methods: Cartilage biopsies were obtained from OA patients and controls. Histological staining and immunohistochemistry for inflammatory markers were performed to characterize the tissues. Chondrocytes cell viability, gene expression of pro-inflammatory mediators, metalloproteinases (MMPs), collagen type II and aggrecan levels were analyzed in primary human chondrocytes isolated from OA patients and exposed to the CM of activated U937 monocytes and subsequently treated with BCP alone or in combination with AA and GlcN. Results: Histology and immunohistochemistry analysis pointed out cartilage degeneration, fragmentation and fissuring in OA patients, associated with the presence of positivity to inflammatory molecules compared to controls. The macrophage-derived CM induced a decrease of chondrocyte viability and a significantly increase of inflammatory molecules and MMPs expression. When BCP was added to the inflamed cells, alone or in combination with AA and GlcN, there was an increase of cell viability, a decrease of gene expression of interleukin-1 beta, NF-κB1 and MMP-13 and an increase of ECM matrix molecules (aggrecan and type II collagen). Conclusions: Low-doses of BCP are effective in counteracting the inflammatory effects determined by macrophage-derived CM stimulation on chondrocytes. Moreover, the combined used of BCP, AA and GlcN seems to have synergistic effects in protecting chondrocytes. [ABSTRACT FROM AUTHOR]
Published: 2022

31. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author: Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke-Jan, Grallert, Harald, Perry, John RB, Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L, Dimas, Antigone S, Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R, Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G, Isaacs, Aaron, Willems, Sara M, Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U, Montasser, May E, O'Connell, Jeff R, Bielak, Lawrence F, Webster, Rebecca J, Saxena, Richa, Stafford, Jeanette M, Pourcain, Beate St, Timpson, Nicholas J, Salo, Perttu, Shin, So-Youn, Amin, Najaf, Smith, Albert V, Li, Guo, Verweij, Niek, Goel, Anuj, Ford, Ian, Johnson, Paul CD, Johnson, Toby, Kapur, Karen, Thorleifsson, Gudmar, Strawbridge, Rona J, Rasmussen-Torvik, Laura J, Esko, Tõnu, Mihailov, Evelin, Fall, Tove, Fraser, Ross M, Mahajan, Anubha, Kanoni, Stavroula, Giedraitis, Vilmantas, Kleber, Marcus E, Silbernagel, Günther, Meyer, Julia, Müller-Nurasyid, Martina, Ganna, Andrea, Sarin, Antti-Pekka, Yengo, Loic, Shungin, Dmitry, Luan, Jian'an, Horikoshi, Momoko, An, Ping, Sanna, Serena, Boettcher, Yvonne, Rayner, N William, Nolte, Ilja M, Zemunik, Tatijana, Iperen, Erik Van, Kovacs, Peter, Hastie, Nicholas D, Wild, Sarah H, McLachlan, Stela, Campbell, Susan, Polasek, Ozren, Carlson, Olga, Egan, Josephine, Kiess, Wieland, Willemsen, Gonneke, Kuusisto, Johanna, Laakso, Markku, Dimitriou, Maria, Hicks, Andrew A, Rauramaa, Rainer, Bandinelli, Stefania, Thorand, Barbara, Liu, Yongmei, Miljkovic, Iva, Lind, Lars, Doney, Alex, Perola, Markus, Hingorani, Aroon, Kivimaki, Mika, Kumari, Meena, Bennett, Amanda J, Groves, Christopher J, Herder, Christian, Koistinen, Heikki A, Kinnunen, Leena, Faire, Ulf De, Bakker, Stephan JL, Uusitupa, Matti, Palmer, Colin NA, Jukema, J Wouter, Sattar, Naveed, Pouta, Anneli, Snieder, Harold, Boerwinkle, Eric, Pankow, James S, Magnusson, Patrik K, Krus, Ulrika, Scapoli, Chiara, De Geus, Eco JCN, Blüher, Matthias, Wolffenbuttel, Bruce HR, Province, Michael A, Abecasis, Goncalo R, Meigs, James B, Hovingh, G Kees, Lindström, Jaana, Wilson, James F, Wright, Alan F, Dedoussis, George V, Bornstein, Stefan R, Schwarz, Peter EH, Tönjes, Anke, Winkelmann, Bernhard R, Boehm, Bernhard O, März, Winfried, Metspalu, Andres, Price, Jackie F, Deloukas, Panos, Körner, Antje, Lakka, Timo A, Keinanen-Kiukaanniemi, Sirkka M, Saaristo, Timo E, Bergman, Richard N, Tuomilehto, Jaakko, Wareham, Nicholas J, Langenberg, Claudia, Männistö, Satu, Franks, Paul W, Hayward, Caroline, Vitart, Veronique, Kaprio, Jaakko, Visvikis-Siest, Sophie, Balkau, Beverley, Altshuler, David, Rudan, Igor, Stumvoll, Michael, Campbell, Harry, Van Duijn, Cornelia M, Gieger, Christian, Illig, Thomas, Ferrucci, Luigi, Pedersen, Nancy L, Pramstaller, Peter P, Boehnke, Michael, Frayling, Timothy M, Shuldiner, Alan R, Peyser, Patricia A, Kardia, Sharon LR, Palmer, Lyle J, Penninx, Brenda W, Meneton, Pierre, Harris, Tamara B, Navis, Gerjan, Harst, Pim Van Der, Smith, George Davey, Forouhi, Nita G, Loos, Ruth JF, Salomaa, Veikko, Soranzo, Nicole, Boomsma, Dorret I, Groop, Leif, Tuomi, Tiinamaija, Hofman, Albert, Munroe, Patricia B, Gudnason, Vilmundur, Siscovick, David S, Watkins, Hugh, Lecoeur, Cecile, Vollenweider, Peter, Franco-Cereceda, Anders, Eriksson, Per, Jarvelin, Marjo-Riitta, Stefansson, Kari, Hamsten, Anders, Nicholson, George, Karpe, Fredrik, Dermitzakis, Emmanouil T, Lindgren, Cecilia M, McCarthy, Mark I, Froguel, Philippe, Kaakinen, Marika A, Lyssenko, Valeriya, Watanabe, Richard M, Ingelsson, Erik, Florez, Jose C, Dupuis, Josée, Barroso, Inês, Morris, Andrew P, Prokopenko, Inga, and Meta-Analyses Of Glucose And Insulin-Related Traits Consortium (MAGIC)
Subjects: Adult, Blood Glucose, Male, Sex Characteristics, Anorexia Nervosa, Waist-Hip Ratio, Kruppel-Like Transcription Factors, Gene Expression, Fasting, Middle Aged, White People, 3. Good health, Phenotype, Sex Factors, Genetic Loci, Glucose Intolerance, Insulin Receptor Substrate Proteins, Humans, Insulin, Female, Insulin Resistance, Genome-Wide Association Study
Abstract: Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.

32. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author: Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke- Jan, Grallert, Harald, Perry, John R. B., Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L., Dimas, Antigone S., Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R., Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G., Isaacs, Aaron, Willems, Sara M., Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U., Montasser, May E., O’Connell, Jeff R., Bielak, Lawrence F., Webster, Rebecca J., Saxena, Richa, Stafford, Jeanette M., Pourcain, Beate St, Timpson, Nicholas J., Salo, Perttu, Shin, So-Youn, Amin, Najaf, Smith, Albert V., Li, Guo, Verweij, Niek, Goel, Anuj, Ford, Ian, Johnson, Paul C. D., Johnson, Toby, Kapur, Karen, Thorleifsson, Gudmar, Strawbridge, Rona J., Rasmussen-Torvik, Laura J., Esko, Tõnu, Mihailov, Evelin, Fall, Tove, Fraser, Ross M., Mahajan, Anubha, Kanoni, Stavroula, Giedraitis, Vilmantas, Kleber, Marcus E., Silbernagel, Günther, Meyer, Julia, Müller-Nurasyid, Martina, Ganna, Andrea, Sarin, Antti-Pekka, Yengo, Loic, Shungin, Dmitry, Luan, Jian’an, Horikoshi, Momoko, An, Ping, Sanna, Serena, Boettcher, Yvonne, Rayner, N. William, Nolte, Ilja M., Zemunik, Tatijana, Iperen, Erik Van, Kovacs, Peter, Hastie, Nicholas D., Wild, Sarah H., McLachlan, Stela, Campbell, Susan, Polasek, Ozren, Carlson, Olga, Egan, Josephine, Kiess, Wieland, Willemsen, Gonneke, Kuusisto, Johanna, Laakso, Markku, Dimitriou, Maria, Hicks, Andrew A., Rauramaa, Rainer, Bandinelli, Stefania, Thorand, Barbara, Liu, Yongmei, Miljkovic, Iva, Lind, Lars, Doney, Alex, Perola, Markus, Hingorani, Aroon, Kivimaki, Mika, Kumari, Meena, Bennett, Amanda J., Groves, Christopher J., Herder, Christian, Koistinen, Heikki A., Kinnunen, Leena, Faire, Ulf De, Bakker, Stephan J. L., Uusitupa, Matti, Palmer, Colin N. A., Jukema, J. Wouter, Sattar, Naveed, Pouta, Anneli, Snieder, Harold, Boerwinkle, Eric, Pankow, James S., Magnusson, Patrik K., Krus, Ulrika, Scapoli, Chiara, De Geus, Eco J. C. N., Blüher, Matthias, Wolffenbuttel, Bruce H. R., Province, Michael A., Abecasis, Goncalo R., Meigs, James B., Hovingh, G. Kees, Lindström, Jaana, Wilson, James F., Wright, Alan F., Dedoussis, George V., Bornstein, Stefan R., Schwarz, Peter E. H., Tönjes, Anke, Winkelmann, Bernhard R., Boehm, Bernhard O., März, Winfried, Metspalu, Andres, Price, Jackie F., Deloukas, Panos, Körner, Antje, Lakka, Timo A., Keinanen-Kiukaanniemi, Sirkka M., Saaristo, Timo E., Bergman, Richard N., Tuomilehto, Jaakko, Wareham, Nicholas J., Langenberg, Claudia, Männistö, Satu, Franks, Paul W., Hayward, Caroline, Vitart, Veronique, Kaprio, Jaakko, Visvikis-Siest, Sophie, Balkau, Beverley, Altshuler, David, Rudan, Igor, Stumvoll, Michael, Campbell, Harry, Van Duijn, Cornelia M., Gieger, Christian, Illig, Thomas, Ferrucci, Luigi, Pedersen, Nancy L., Pramstaller, Peter P., Boehnke, Michael, Frayling, Timothy M., Shuldiner, Alan R., Peyser, Patricia A., Kardia, Sharon L. R., Palmer, Lyle J., Penninx, Brenda W., Meneton, Pierre, Harris, Tamara B., Navis, Gerjan, Harst, Pim Van Der, Smith, George Davey, Forouhi, Nita G., Loos, Ruth J. F., Salomaa, Veikko, Soranzo, Nicole, Boomsma, Dorret I., Groop, Leif, Tuomi, Tiinamaija, Hofman, Albert, Munroe, Patricia B., Gudnason, Vilmundur, Siscovick, David S., Watkins, Hugh, Lecoeur, Cecile, Vollenweider, Peter, Franco-Cereceda, Anders, Eriksson, Per, Jarvelin, Marjo-Riitta, Stefansson, Kari, Hamsten, Anders, Nicholson, George, Karpe, Fredrik, Dermitzakis, Emmanouil T., Lindgren, Cecilia M., McCarthy, Mark I., Froguel, Philippe, Kaakinen, Marika A., Lyssenko, Valeriya, Watanabe, Richard M., Ingelsson, Erik, Florez, Jose C., Dupuis, Josée, Barroso, Inês, Morris, Andrew P., and Prokopenko, Inga
Subjects: 692/699/2743/2815, 631/208/205/2138, 692/53/2421, 45/43, article, 631/208/480, 692/163/2743/137/773, 3. Good health
Abstract: Funder: EU H2020, Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.

33. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author: Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke- Jan, Grallert, Harald, Perry, John R. B., Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L., Dimas, Antigone S., Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R., Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G., Isaacs, Aaron, Willems, Sara M., Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U., Montasser, May E., O’Connell, Jeff R., Bielak, Lawrence F., Webster, Rebecca J., Saxena, Richa, Stafford, Jeanette M., Pourcain, Beate St, Timpson, Nicholas J., Salo, Perttu, Shin, So-Youn, Amin, Najaf, Smith, Albert V., Li, Guo, Verweij, Niek, Goel, Anuj, Ford, Ian, Johnson, Paul C. D., Johnson, Toby, Kapur, Karen, Thorleifsson, Gudmar, Strawbridge, Rona J., Rasmussen-Torvik, Laura J., Esko, Tõnu, Mihailov, Evelin, Fall, Tove, Fraser, Ross M., Mahajan, Anubha, Kanoni, Stavroula, Giedraitis, Vilmantas, Kleber, Marcus E., Silbernagel, Günther, Meyer, Julia, Müller-Nurasyid, Martina, Ganna, Andrea, Sarin, Antti-Pekka, Yengo, Loic, Shungin, Dmitry, Luan, Jian’an, Horikoshi, Momoko, An, Ping, Sanna, Serena, Boettcher, Yvonne, Rayner, N. William, Nolte, Ilja M., Zemunik, Tatijana, Iperen, Erik Van, Kovacs, Peter, Hastie, Nicholas D., Wild, Sarah H., McLachlan, Stela, Campbell, Susan, Polasek, Ozren, Carlson, Olga, Egan, Josephine, Kiess, Wieland, Willemsen, Gonneke, Kuusisto, Johanna, Laakso, Markku, Dimitriou, Maria, Hicks, Andrew A., Rauramaa, Rainer, Bandinelli, Stefania, Thorand, Barbara, Liu, Yongmei, Miljkovic, Iva, Lind, Lars, Doney, Alex, Perola, Markus, Hingorani, Aroon, Kivimaki, Mika, Kumari, Meena, Bennett, Amanda J., Groves, Christopher J., Herder, Christian, Koistinen, Heikki A., Kinnunen, Leena, Faire, Ulf De, Bakker, Stephan J. L., Uusitupa, Matti, Palmer, Colin N. A., Jukema, J. Wouter, Sattar, Naveed, Pouta, Anneli, Snieder, Harold, Boerwinkle, Eric, Pankow, James S., Magnusson, Patrik K., Krus, Ulrika, Scapoli, Chiara, De Geus, Eco J. C. N., Blüher, Matthias, Wolffenbuttel, Bruce H. R., Province, Michael A., Abecasis, Goncalo R., Meigs, James B., Hovingh, G. Kees, Lindström, Jaana, Wilson, James F., Wright, Alan F., Dedoussis, George V., Bornstein, Stefan R., Schwarz, Peter E. H., Tönjes, Anke, Winkelmann, Bernhard R., Boehm, Bernhard O., März, Winfried, Metspalu, Andres, Price, Jackie F., Deloukas, Panos, Körner, Antje, Lakka, Timo A., Keinanen-Kiukaanniemi, Sirkka M., Saaristo, Timo E., Bergman, Richard N., Tuomilehto, Jaakko, Wareham, Nicholas J., Langenberg, Claudia, Männistö, Satu, Franks, Paul W., Hayward, Caroline, Vitart, Veronique, Kaprio, Jaakko, Visvikis-Siest, Sophie, Balkau, Beverley, Altshuler, David, Rudan, Igor, Stumvoll, Michael, Campbell, Harry, Van Duijn, Cornelia M., Gieger, Christian, Illig, Thomas, Ferrucci, Luigi, Pedersen, Nancy L., Pramstaller, Peter P., Boehnke, Michael, Frayling, Timothy M., Shuldiner, Alan R., Peyser, Patricia A., Kardia, Sharon L. R., Palmer, Lyle J., Penninx, Brenda W., Meneton, Pierre, Harris, Tamara B., Navis, Gerjan, Harst, Pim Van Der, Smith, George Davey, Forouhi, Nita G., Loos, Ruth J. F., Salomaa, Veikko, Soranzo, Nicole, Boomsma, Dorret I., Groop, Leif, Tuomi, Tiinamaija, Hofman, Albert, Munroe, Patricia B., Gudnason, Vilmundur, Siscovick, David S., Watkins, Hugh, Lecoeur, Cecile, Vollenweider, Peter, Franco-Cereceda, Anders, Eriksson, Per, Jarvelin, Marjo-Riitta, Stefansson, Kari, Hamsten, Anders, Nicholson, George, Karpe, Fredrik, Dermitzakis, Emmanouil T., Lindgren, Cecilia M., McCarthy, Mark I., Froguel, Philippe, Kaakinen, Marika A., Lyssenko, Valeriya, Watanabe, Richard M., Ingelsson, Erik, Florez, Jose C., Dupuis, Josée, Barroso, Inês, Morris, Andrew P., and Prokopenko, Inga
Subjects: 692/699/2743/2815, 631/208/205/2138, 692/53/2421, 45/43, article, 631/208/480, 692/163/2743/137/773, 3. Good health
Abstract: Funder: EU H2020, Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.

34. Computational investigation of the clustering of droplets in widening pipe geometries

Author: De Stefano, C., Fontanella, F., Vanneschi, L., Matuttis, Hans-Georg, Schneider, Johannes Josef, Li, Jin, Barrow, David Anthony, Faggian, Alessia, Diaz, Aitor Patiño, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Weyland, Mathias Sebastian, Flumini, Dandolo, Hotz, Peter Eggenberger, Dimitriou, Pantelitsa, Jamieson, William David, Castell, Oliver, Füchslin, Rudolf Marcel, De Stefano, C., Fontanella, F., Vanneschi, L., Matuttis, Hans-Georg, Schneider, Johannes Josef, Li, Jin, Barrow, David Anthony, Faggian, Alessia, Diaz, Aitor Patiño, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Weyland, Mathias Sebastian, Flumini, Dandolo, Hotz, Peter Eggenberger, Dimitriou, Pantelitsa, Jamieson, William David, Castell, Oliver, and Füchslin, Rudolf Marcel
Abstract: Experimentally, periodically released droplets in systems of widening pipes show clustering. This is surprising, as purely hydrodynamic interactions are repulsive so that agglomeration should be prevented. In the main part of this paper, we investigate the clustering of droplets under the influence of phenomenological hydrostatic forces and some hypothetical attraction. In two appendices, we explain why a direct numerical simulation for this system is rather more difficult (and probably not possible with current methods) than the “simple” geometry would suggest.

35. Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer

Author: De Stefano, C., Fontanella, F., Vanneschi, L., Schneider, Johannes Josef, Faggian, Alessia, Jamieson, William David, Weyland, Mathias Sebastian, Li, Jin, Castell, Oliver, Matuttis, Hans-Georg, Barrow, David Anthony, Diaz, Aitor Patiño, Sanahuja, Lorena Cebolla, Holler, Silvia, Casiraghi, Federica, Hanczyc, Martin Michael, Flumini, Dandolo, Eggenberger Hotz, Peter, Füchslin, Rudolf Marcel, De Stefano, C., Fontanella, F., Vanneschi, L., Schneider, Johannes Josef, Faggian, Alessia, Jamieson, William David, Weyland, Mathias Sebastian, Li, Jin, Castell, Oliver, Matuttis, Hans-Georg, Barrow, David Anthony, Diaz, Aitor Patiño, Sanahuja, Lorena Cebolla, Holler, Silvia, Casiraghi, Federica, Hanczyc, Martin Michael, Flumini, Dandolo, Eggenberger Hotz, Peter, and Füchslin, Rudolf Marcel
Abstract: Within the scope of the European Horizon 2020 project ACDC – Artificial Cells with Distributed Cores to Decipher Protein Function, we aim at the development of a chemical compiler governing the three-dimensional arrangement of droplets, which are filled with various chemicals. Neighboring droplets form bilayers with pores which allow chemicals to move from one droplet to its neighbors. With an appropriate three-dimensional configuration of droplets, we can thus enable gradual biochemical reaction schemes for various purposes, e.g., for the production of macromolecules for pharmaceutical purposes. In this paper, we demonstrate with artificial chemistry simulations that the ACDC technology is excellently suitable to maximize the yield of desired reaction products or to minimize the relative output of unwanted side products.

36. Obstacles on the pathway towards chemical programmability using agglomerations of droplets

Author: Schneider, Johannes Josef, Faggian, Alessia, Matuttis, Hans-Georg, Barrow, David Anthony, Li, Jin, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Eschle, Patrik, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, Füchslin, Rudolf Marcel, Schneider, Johannes Josef, Faggian, Alessia, Matuttis, Hans-Georg, Barrow, David Anthony, Li, Jin, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Eschle, Patrik, Weyland, Mathias Sebastian, Flumini, Dandolo, Eggenberger Hotz, Peter, and Füchslin, Rudolf Marcel
Abstract: We aim at planning and creating specific agglomerations of droplets to study synergic communication using these as programmable units. In this paper, we give an overview of preliminary obstacles for the various research issues, namely of how to create droplets, how to set up droplet agglomerations using DNA technology, how to prepare them for confocal microscopy, how to make a computer see droplets on photos, how to analyze networks of droplets, how to perform simulations mimicking experiments, and how to plan specific agglomerations of droplets.

37. Influence of the geometry on the agglomeration of a polydisperse binary system of spherical particles

Author: Schneider, Johannes Josef, Faggian, Alessia, Holler, Silvia, Casiraghi, Federica, Li, Jin, Sanahuja, Lorena Cebolla, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David, Weyland, Mathias Sebastian, Flumini, Dandolo, Hotz, Peter Eggenberger, Fuchslin, Rudolf Marcel, Schneider, Johannes Josef, Faggian, Alessia, Holler, Silvia, Casiraghi, Federica, Li, Jin, Sanahuja, Lorena Cebolla, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David, Weyland, Mathias Sebastian, Flumini, Dandolo, Hotz, Peter Eggenberger, and Fuchslin, Rudolf Marcel
Abstract: Within the context of the European Horizon 2020 project ACDC, we intend to develop a probabilistic chemical compiler, to aid the construction of three-dimensional agglomerations of artificial hierarchical cellular constructs. These programmable discrete units offer a wide variety of technical innovations, like a portable biochemical laboratory that e.g. produces macromolecular medicine on demand. For this purpose, we have to investigate the agglomeration process of droplets and vesicles under proposed constraints, like confinement. This paper focuses on the influence of the geometry of the initialization and of the container on the agglomeration.

38. Paths in a network of polydisperse spherical droplets

Author: Schneider, Johannes Josef, Faggian, Alessia, Holler, Silvia, Casiraghi, Federica, Li, Jin, Sanahuja, Lorena Cebolla, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David Anthony, Weyland, Mathias Sebastian, Flumini, Dandolo, Hotz, Peter Eggenberger, Eschle, Patrik, Diaz, Aitor Patiño, Füchslin, Rudolf Marcel, Schneider, Johannes Josef, Faggian, Alessia, Holler, Silvia, Casiraghi, Federica, Li, Jin, Sanahuja, Lorena Cebolla, Matuttis, Hans-Georg, Hanczyc, Martin Michael, Barrow, David Anthony, Weyland, Mathias Sebastian, Flumini, Dandolo, Hotz, Peter Eggenberger, Eschle, Patrik, Diaz, Aitor Patiño, and Füchslin, Rudolf Marcel
Abstract: We simulate the movement and agglomeration of oil droplets in water under constraints, like confinement, using a simplified stochastic-hydrodynamic model. In the analysis of the network created by the droplets in the agglomeration, we focus on the paths between pairs of droplets and compare the computational results for various system sizes.

39. Percolation breakdown in binary and ternary monodisperse and polydisperse systems of spherical particles

Author: Villani, M., Cagnoni, S., Serra, R., Schneider, Johannes Josef, Faggian, Alessia, Weyland, Mathias Sebastian, Jamieson, William, Li, Jin, Matuttis, Hans-Georg, Holler, Silvia, Casiraghi, Federica, Diaz, Aitor Patino, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Flumini, Dandolo, Hotz, Peter Eggenberger, Barrow, David, Dimitriou, Pantelitsa, Castell, Oliver, Fuchslin, Rudolf Marcel, Villani, M., Cagnoni, S., Serra, R., Schneider, Johannes Josef, Faggian, Alessia, Weyland, Mathias Sebastian, Jamieson, William, Li, Jin, Matuttis, Hans-Georg, Holler, Silvia, Casiraghi, Federica, Diaz, Aitor Patino, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Flumini, Dandolo, Hotz, Peter Eggenberger, Barrow, David, Dimitriou, Pantelitsa, Castell, Oliver, and Fuchslin, Rudolf Marcel
Abstract: We perform computer simulations of an agglomeration process for monodisperse and polydisperse systems of spherical particles in a cylindrical container, using a simplified stochastic-hydrodynamic model. We consider a ternary system with three particle types A, B, and C, in which only connections of the type can be forged, while any other connections with particles of the same type or with C-particles are forbidden, and for comparison a binary system with two particle types A and C, in which only connections of the type can be formed. We study the breakdown of the percolation in the agglomeration at the bottom of the cylinder with an increasing fraction of C-particles.

40. Kauffman Model with spatially separated ligation and cleavage reactions

Author: Villani, M., Cagnoni, S., Serra, R., Schneider, Johannes Josef, Hotz, Peter Eggenberger, Jamieson, William David, Faggian, Alessia, Li, Jin, Matuttis, Hans-Georg, Caliari, Adriano, Weyland, Mathias Sebastian, Flumini, Dandolo, Diaz, Aitor Patino, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Barrow, David, Dimitriou, Pantelitsa, Castell, Oliver, Fuchslin, Rudolf Marcel, Villani, M., Cagnoni, S., Serra, R., Schneider, Johannes Josef, Hotz, Peter Eggenberger, Jamieson, William David, Faggian, Alessia, Li, Jin, Matuttis, Hans-Georg, Caliari, Adriano, Weyland, Mathias Sebastian, Flumini, Dandolo, Diaz, Aitor Patino, Holler, Silvia, Casiraghi, Federica, Sanahuja, Lorena Cebolla, Hanczyc, Martin Michael, Barrow, David, Dimitriou, Pantelitsa, Castell, Oliver, and Fuchslin, Rudolf Marcel
Abstract: One of the open questions regarding the origin of life is the problem how macromolecules could be created. One possible answer is the existence of autocatalytic sets in which some macromolecules mutually catalyze each other’s formation. This mechanism is theoretically described in the Kauffman model. We introduce and simulate an extension of the Kauffman model, in which ligation and cleavage reactions are spatially separated in different containers connected by diffusion, and provide computational results for instances with and without autocatalytic sets, focusing on the time evolution of the densities of the various molecules. Furthermore, we study the rich behavior of a randomly generated instance containing an autocatalytic metabolism, in which molecules are created by ligation processes and destroyed by cleavage processes and vice versa or generated and destroyed both by ligation processes.

41. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author: Tove Fall, Anubha Mahajan, Dmitry Shungin, B. Balkau, Gerjan Navis, A. Metspalu, Anneli Pouta, Andrew A. Hicks, Ilja M. Nolte, Ian Ford, Aroon D. Hingorani, Stefan R Bornstein, Anuj Goel, Rona J. Strawbridge, Niek Verweij, Sarah H. Wild, Patricia B. Munroe, T.B. Harris, Jaana Lindström, Johnson Pcd., Nita G. Forouhi, Pierre Meneton, Patricia A. Peyser, Sarin A-P., Andrea Ganna, Timothy M. Frayling, Patrik K. E. Magnusson, Joanne M. Meyer, Yongmei Liu, Jeanette M. Stafford, Christian Herder, L Zudina, Maria G. Stathopoulou, May E. Montasser, Nicholas D. Hastie, Inês Barroso, Schwarz Peh., James B. Meigs, Perttu Salo, George Davey Smith, Gonneke Willemsen, Christopher J. Groves, Erik P A Van Iperen, M. A. Province, Veikko Salomaa, Naveed Sattar, Serena Sanna, Maria Dimitriou, Joop Jukema, Ulrika Krus, Albert V. Smith, Markku Laakso, James F. Wilson, George Nicholson, Loic Yengo, Tatijana Zemunik, Per Eriksson, Harold Snieder, Peter P. Pramstaller, Claudia Langenberg, R. Rauramaa, Alan R. Shuldiner, Pau Navarro, Veronique Vitart, Ross M. Fraser, Aaron Isaacs, C. Lecoeur, Jesper R. Gådin, Jackie F. Price, Letizia Marullo, L.F. Bielak, Sirkka Keinänen-Kiukaanniemi, Amélie Bonnefond, Michael Stumvoll, Alessia Faggian, Anke Tönjes, Tomohiro Tanaka, Wieland Kiess, Harry Campbell, Josée Dupuis, David Altshuler, João Fadista, Winfried März, G K Hovingh, Thomas Illig, Toby Johnson, H Grallert, Kari Stefansson, Reedik Mägi, Palmer Cna., de Geus Ejcn., Martina Müller-Nurasyid, Karen Kapur, Philippe Froguel, Dorret I. Boomsma, Anders Franco-Cereceda, Marcus E. Kleber, Boehnke M, Olga D. Carlson, Ozren Polasek, Andrew P. Morris, Alex S. F. Doney, Najaf Amin, Sara M. Willems, Vilmundur Gudnason, Jose C. Florez, Jeffery R. O'Connell, Nancy L. Pedersen, T. Saaristo, Wolffenbuttel Bhr., M. I. J. Uusitupa, Longda Jiang, Iva Miljkovic, James S. Pankow, Caroline Hayward, Hugh Watkins, Vasiliki Lagou, Johanna Kuusisto, Jaakko Tuomilehto, Alan F. Wright, Josephine M. Egan, Perry Jrb., C M van Duijn, Valeriya Lyssenko, Leif Groop, Stefania Bandinelli, Nigel W. Rayner, Tõnu Esko, Stela McLachlan, Momoko Horikoshi, Eric Boerwinkle, Rick Jansen, Richard N. Bergman, Gudmar Thorleifsson, Lyle J. Palmer, Vilmantas Giedraitis, Peter Kovacs, Nicholas J. Wareham, Luigi Ferrucci, N J Timpson, D Rybin, Anne U. Jackson, Tiinamaija Tuomi, Gonçalo R. Abecasis, Harst Pvd., Meena Kumari, Albert Hofman, Chiara Scapoli, Evelin Mihailov, Josine L. Min, Anders Hamsten, Hottenga J-J., Loos Rjf., Lars Lind, Ulf de Faire, Jaakko Kaprio, Guo Li, Beate St Pourcain, C Gieger, Amanda J. Bennett, Anna Ulrich, Nabila Bouatia-Naji, Satu Männistö, Antigone S. Dimas, Jarvelin M-R., Günther Silbernagel, F Karpe, A. Körner, David S. Siscovick, M Blüher, Rebecca J. Webster, Erik Ingelsson, Susan Campbell, Mika Kivimäki, Laura J. Rasmussen-Torvik, Heikki A. Koistinen, Sophie Visvikis-Siest, Bernhard O. Boehm, Inga Prokopenko, Ping An, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Kardia Slr., Richa Saxena, Igor Rudan, Richard M. Watanabe, Jian'an Luan, Marika Kaakinen, Shin S-Y., George Dedoussis, Panagiotis Deloukas, Mark I. McCarthy, Barbara Thorand, B.W.J.H. Penninx, Peter Vollenweider, Paul W. Franks, Leena Kinnunen, Markus Perola, Yvonne Boettcher, Timo A. Lakka, Nicole Soranzo, Stavroula Kanoni, Bakker Sjl., Winkelmann Br, The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford [Oxford], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institute of Genomics [Tartu, Estonia], University of Tartu, Vrije Universiteit Amsterdam [Amsterdam] (VU), Vrije Universiteit Medical Centre (VUMC), Helmholtz-Zentrum München (HZM), University of Cambridge [UK] (CAM), Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Università degli Studi di Ferrara (UniFE), Boston University [Boston] (BU), VU University Medical Center [Amsterdam], University of Bristol [Bristol], Biomedical Sciences Research Centre Alexander Fleming [Vari, Greece] (BSRC), Imperial College London, Karolinska Institutet [Stockholm], Institute for Molecular Bioscience, University of Queensland [Brisbane], Statens Serum Institut [Copenhagen], Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University [Maastricht], MRC Institute of Genetics and Molecular Medicine [Edinburgh] (IGMM), University of Edinburgh-Medical Research Council, National Institute on Aging [Baltimore, MD, USA] (NIH), University of Michigan [Ann Arbor], University of Michigan System, University of Maryland School of Medicine, University of Maryland System, The University of Western Australia (UWA), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), Wake Forest University, National Institute for Health and Welfare [Helsinki], The Wellcome Trust Sanger Institute [Cambridge], University of Iceland [Reykjavik], University of Washington [Seattle], University of Groningen [Groningen], University of Glasgow, William Harvey Research Institute, Barts and the London Medical School, Université de Lausanne (UNIL), deCODE genetics [Reykjavik], Northwestern University Feinberg School of Medicine, Uppsala Universitet [Uppsala], University of Edinburgh, Medical Faculty [Mannheim], University of Graz, Ludwig-Maximilians-Universität München (LMU), Johannes Gutenberg - Universität Mainz (JGU), Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki-University of Helsinki, Umeå University, Skane University Hospital [Malmo], Lund University [Lund], RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche [Roma] (CNR), University Medical Center Groningen [Groningen] (UMCG), Universität Leipzig [Leipzig], Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Split, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), University of Eastern Finland, Harokopio University of Athens, European Academy Bozen/Bolzano (EURAC), University of Kuopio, German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] (DZD), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Ninewells Hospital and Medical School [Dundee], University College of London [London] (UCL), University of Essex, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], University of Helsinki, Leiden University Medical Center (LUMC), Institute of Cardiovascular and Medical Sciences [Glasgow], University of Oulu, The University of Texas Health Science Center at Houston (UTHealth), University of Minnesota Medical School, University of Minnesota System, Keck School of Medicine [Los Angeles], University of Southern California (USC), Amsterdam UMC, University Hospital Carl Gustav Carus [Dresden, Germany], Technische Universität Dresden = Dresden University of Technology (TU Dresden), Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Universität Heidelberg [Heidelberg], King Abdulaziz University, Pirkanmaa Hospital District, Tampere University Hospital, Cedars-Sinai Medical Center, Danube University Krems, Harvard School of Public Health, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Hannover Medical School [Hannover] (MHH), Universität zu Lübeck [Lübeck], University of Exeter, Regeneron Pharmaceuticals [Tarrytown], University of Adelaide, Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Harvard T.H. Chan School of Public Health, John Radcliffe Hospital [Oxford University Hospital], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Université de Genève (UNIGE), Big Data Institute, University of Surrey (UNIS), University of Bergen (UiB), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Stanford Cardiovascular Institute, University of Liverpool, University of Manchester [Manchester], Institute of Biochemistry and Genetics of Ufa Scientific Centre, Russian Academy of Sciences [Moscow] (RAS), Experimental Vascular Medicine, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, SIEST, Sofia, PreciDIAB Institute, the holistic approach of personal diabets care - - PreciDIAB2018 - ANR-18-IBHU-0001 - IBHU - VALID, Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging - DYNAHEALTH - - H20202015-04-01 - 2019-03-31 - 633595 - VALID, Beyond the Genetics of Addiction - ADDICTION - - EC:FP7:ERC2011-12-01 - 2017-05-31 - 284167 - VALID, Rise of scientific excellence and collaboration for implementing personalised medicine in Estonia - ePerMed - - H20202016-01-01 - 2018-12-31 - 692145 - VALID, University of Oxford, Helmholtz Zentrum München = German Research Center for Environmental Health, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Ferrara = University of Ferrara (UniFE), Université de Lausanne = University of Lausanne (UNIL), Karl-Franzens-Universität Graz, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Amsterdam UMC - Amsterdam University Medical Center, Nanyang Technological University [Singapour], Universität zu Lübeck = University of Lübeck [Lübeck], Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, Université de Genève = University of Geneva (UNIGE), ANR-18-IBHU-0001,PreciDIAB,PreciDIAB Institute, the holistic approach of personal diabets care(2018), European Project: 633595,H2020,H2020-PHC-2014-two-stage,DYNAHEALTH(2015), European Project: 284167,EC:FP7:ERC,ERC-2011-StG_20101124,ADDICTION(2011), European Project: 692145,H2020,H2020-TWINN-2015,ePerMed(2016), Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Functional Genomics, APH - Mental Health, Sociology and Social Gerontology, APH - Methodology, Hottenga, Jouke- Jan [0000-0002-5668-2368], Bouatia-Naji, Nabila [0000-0001-5424-2134], Jansen, Rick [0000-0002-3333-6737], Min, Josine L. [0000-0003-4456-9824], Faggian, Alessia [0000-0002-3799-9722], Bonnefond, Amélie [0000-0001-9976-3005], Isaacs, Aaron [0000-0001-5037-4834], Willems, Sara M. [0000-0002-6803-3007], Navarro, Pau [0000-0001-5576-8584], Jackson, Anne U. [0000-0002-9672-2547], Bielak, Lawrence F. [0000-0002-3443-8030], Saxena, Richa [0000-0003-2233-1065], Smith, Albert V. [0000-0003-1942-5845], Verweij, Niek [0000-0002-4303-7685], Goel, Anuj [0000-0003-2307-4021], Johnson, Paul C. D. [0000-0001-6663-7520], Strawbridge, Rona J. [0000-0001-8506-3585], Fall, Tove [0000-0003-2071-5866], Fraser, Ross M. [0000-0003-0488-2592], Kanoni, Stavroula [0000-0002-1691-9615], Giedraitis, Vilmantas [0000-0003-3423-2021], Kleber, Marcus E. [0000-0003-0663-7275], Müller-Nurasyid, Martina [0000-0003-3793-5910], Luan, Jian’an [0000-0003-3137-6337], Sanna, Serena [0000-0002-3768-1749], Nolte, Ilja M. [0000-0001-5047-4077], Zemunik, Tatijana [0000-0001-8120-2891], Kovacs, Peter [0000-0002-0290-5423], Wild, Sarah H. [0000-0001-7824-2569], McLachlan, Stela [0000-0003-0480-6143], Egan, Josephine [0000-0002-8945-0053], Hicks, Andrew A. [0000-0001-6320-0411], Thorand, Barbara [0000-0002-8416-6440], Hingorani, Aroon [0000-0001-8365-0081], Kivimaki, Mika [0000-0002-4699-5627], Koistinen, Heikki A. [0000-0001-7870-070X], Bakker, Stephan J. L. [0000-0003-3356-6791], Palmer, Colin N. A. [0000-0002-6415-6560], Jukema, J. Wouter [0000-0002-3246-8359], Sattar, Naveed [0000-0002-1604-2593], Snieder, Harold [0000-0003-1949-2298], Magnusson, Patrik K. [0000-0002-7315-7899], Blüher, Matthias [0000-0003-0208-2065], Wolffenbuttel, Bruce H. R. [0000-0001-9262-6921], Abecasis, Goncalo R. [0000-0003-1509-1825], Meigs, James B. [0000-0002-2439-2657], Wilson, James F. [0000-0001-5751-9178], Schwarz, Peter E. H. [0000-0001-6317-7880], Boehm, Bernhard O. [0000-0002-2706-7710], Metspalu, Andres [0000-0002-3718-796X], Deloukas, Panos [0000-0001-9251-070X], Körner, Antje [0000-0001-6001-0356], Wareham, Nicholas J. [0000-0003-1422-2993], Langenberg, Claudia [0000-0002-5017-7344], Männistö, Satu [0000-0002-8668-3046], Franks, Paul W. [0000-0002-0520-7604], Hayward, Caroline [0000-0002-9405-9550], Vitart, Veronique [0000-0002-4991-3797], Kaprio, Jaakko [0000-0002-3716-2455], Visvikis-Siest, Sophie [0000-0001-8104-8425], Altshuler, David [0000-0002-7250-4107], Rudan, Igor [0000-0001-6993-6884], van Duijn, Cornelia M. [0000-0002-2374-9204], Pramstaller, Peter P. [0000-0002-9831-8302], Boehnke, Michael [0000-0002-6442-7754], Frayling, Timothy M. [0000-0001-8362-2603], Peyser, Patricia A. [0000-0002-9717-8459], Harst, Pim van der [0000-0002-2713-686X], Smith, George Davey [0000-0002-1407-8314], Forouhi, Nita G. [0000-0002-5041-248X], Loos, Ruth J. F. [0000-0002-8532-5087], Salomaa, Veikko [0000-0001-7563-5324], Soranzo, Nicole [0000-0003-1095-3852], Boomsma, Dorret I. [0000-0002-7099-7972], Groop, Leif [0000-0002-0187-3263], Tuomi, Tiinamaija [0000-0002-8306-6202], Munroe, Patricia B. [0000-0002-4176-2947], Gudnason, Vilmundur [0000-0001-5696-0084], Lecoeur, Cecile [0000-0003-0075-6417], Jarvelin, Marjo-Riitta [0000-0002-2149-0630], Stefansson, Kari [0000-0003-1676-864X], Dermitzakis, Emmanouil T. [0000-0002-9302-6490], Lindgren, Cecilia M. [0000-0002-4903-9374], Froguel, Philippe [0000-0003-2972-0784], Kaakinen, Marika A. [0000-0002-9228-0462], Watanabe, Richard M. [0000-0003-1015-0531], Ingelsson, Erik [0000-0003-2256-6972], Dupuis, Josée [0000-0003-2871-3603], Barroso, Inês [0000-0001-5800-4520], Apollo - University of Cambridge Repository, Epidemiology, University Hospital Mannheim | Universitätsmedizin Mannheim, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Universität Leipzig, Universiteit Leiden, Universität Heidelberg [Heidelberg] = Heidelberg University, Karl-Franzens-Universität [Graz, Autriche], Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, General practice, APH - Digital Health, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Center for Liver, Digestive and Metabolic Diseases (CLDM), Value, Affordability and Sustainability (VALUE), Cardiovascular Centre (CVC), Hottenga, Jouke-Jan [0000-0002-5668-2368], Min, Josine L [0000-0003-4456-9824], Willems, Sara M [0000-0002-6803-3007], Jackson, Anne U [0000-0002-9672-2547], Bielak, Lawrence F [0000-0002-3443-8030], Smith, Albert V [0000-0003-1942-5845], Johnson, Paul CD [0000-0001-6663-7520], Strawbridge, Rona J [0000-0001-8506-3585], Fraser, Ross M [0000-0003-0488-2592], Kleber, Marcus E [0000-0003-0663-7275], Luan, Jian'an [0000-0003-3137-6337], Nolte, Ilja M [0000-0001-5047-4077], Wild, Sarah H [0000-0001-7824-2569], Hicks, Andrew A [0000-0001-6320-0411], Koistinen, Heikki A [0000-0001-7870-070X], Bakker, Stephan JL [0000-0003-3356-6791], Palmer, Colin NA [0000-0002-6415-6560], Jukema, J Wouter [0000-0002-3246-8359], Magnusson, Patrik K [0000-0002-7315-7899], Wolffenbuttel, Bruce HR [0000-0001-9262-6921], Abecasis, Goncalo R [0000-0003-1509-1825], Meigs, James B [0000-0002-2439-2657], Wilson, James F [0000-0001-5751-9178], Schwarz, Peter EH [0000-0001-6317-7880], Boehm, Bernhard O [0000-0002-2706-7710], Wareham, Nicholas J [0000-0003-1422-2993], Franks, Paul W [0000-0002-0520-7604], van Duijn, Cornelia M [0000-0002-2374-9204], Pramstaller, Peter P [0000-0002-9831-8302], Frayling, Timothy M [0000-0001-8362-2603], Peyser, Patricia A [0000-0002-9717-8459], Forouhi, Nita G [0000-0002-5041-248X], Loos, Ruth JF [0000-0002-8532-5087], Boomsma, Dorret I [0000-0002-7099-7972], Munroe, Patricia B [0000-0002-4176-2947], Dermitzakis, Emmanouil T [0000-0002-9302-6490], Lindgren, Cecilia M [0000-0002-4903-9374], Kaakinen, Marika A [0000-0002-9228-0462], Watanabe, Richard M [0000-0003-1015-0531], Tampere University, Tays Research Services, Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), Fysiologie, RS: FHML MaCSBio, and RS: Carim - B01 Blood proteins & engineering
Subjects: Male, Anorexia Nervosa, medicine.medical_treatment, 45/43, Insulin Resistance/genetics, SUSCEPTIBILITY, Quantitative trait, Impaired glucose tolerance, 0302 clinical medicine, Architecture, LS2_1, IMPUTATION, Insulin, ComputingMilieux_MISCELLANEOUS, Fasting, Publisher Correction, 3. Good health, [SDV] Life Sciences [q-bio], Kruppel-Like Transcription Factors/blood, Endokrinologi och diabetes, Science & Technology - Other Topics, Adult, Blood Glucose, European Continental Ancestry Group, Female, Gene Expression, Genetic Loci, Genome-Wide Association Study, Glucose Intolerance, Humans, Insulin Receptor Substrate Proteins, Insulin Resistance, Kruppel-Like Transcription Factors, Middle Aged, Phenotype, Sex Characteristics, Sex Factors, Waist-Hip Ratio, Sex characteristics, medicine.medical_specialty, Science, 631/208/205/2138, Endocrinology and Diabetes, General Biochemistry, Genetics and Molecular Biology, White People, Gender-differences, 03 medical and health sciences, SDG 3 - Good Health and Well-being, 692/53/2421, GLYCEMIC TRAITS, GENOME-WIDE ASSOCIATION, Glycemic, GENDER-DIFFERENCES, Science & Technology, IDENTIFICATION, 692/699/2743/2815, Blood Glucose/metabolism, Diagnostic markers, medicine.disease, Anorexia Nervosa/blood, 030104 developmental biology, Endocrinology, Glucose, Insulin/blood, Anorexia Nervosa/ethnology, Anorexia Nervosa/genetics, Anorexia Nervosa/physiopathology, Fasting/blood, Glucose Intolerance/blood, Glucose Intolerance/ethnology, Glucose Intolerance/genetics, Glucose Intolerance/physiopathology, Insulin Receptor Substrate Proteins/blood, Insulin Receptor Substrate Proteins/genetics, Kruppel-Like Transcription Factors/genetics, 0301 basic medicine, Identification, [SDV]Life Sciences [q-bio], General Physics and Astronomy, Genome-wide association studies, Waist–hip ratio, LS4_5, RISK, ARCHITECTURE, Multidisciplinary, article, Type 2 diabetes, Multidisciplinary Sciences, MENDELIAN RANDOMIZATION, Pre-diabetes, Medical Genetics, Risk, PATHOPHYSIOLOGY, 030209 endocrinology & metabolism, 3121 Internal medicine, 692/163/2743/137/773, NO, Insulin resistance, Internal medicine, Diabetes mellitus, medicine, Mendelian randomization, 631/208/480, Medicinsk genetik, business.industry, General Chemistry, Impaired fasting glucose, business
Abstract: Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes., Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.
Published: 2021

42. In vitro chronic glycation induces AGEs accumulation reducing insulin-stimulated glucose uptake and increasing GLP1R in adipocytes.

Author: Chilelli NC, Faggian A, Favaretto F, Milan G, Compagnin C, Dassie F, Bettini S, Roverso M, Seraglia R, Lapolla A, and Vettor R
Subjects: 3T3-L1 Cells, Adipocytes physiology, Adipogenesis drug effects, Animals, Biological Transport drug effects, Cell Differentiation drug effects, Cells, Cultured, Glucagon-Like Peptide-1 Receptor drug effects, Glucose metabolism, Glucose pharmacology, Glycosylation drug effects, Humans, Insulin metabolism, Mice, Serum Albumin, Bovine metabolism, Adipocytes drug effects, Glucagon-Like Peptide-1 Receptor metabolism, Glucose pharmacokinetics, Glycation End Products, Advanced metabolism, Insulin pharmacology
Abstract: Intracellular AGEs accumulation increases RAGE and GLP1R and reduces glucose uptake in adipocytes.
Published: 2021
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43. Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Author: Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, Isaacs A, Willems SM, Navarro P, Tanaka T, Jackson AU, Montasser ME, O'Connell JR, Bielak LF, Webster RJ, Saxena R, Stafford JM, Pourcain BS, Timpson NJ, Salo P, Shin SY, Amin N, Smith AV, Li G, Verweij N, Goel A, Ford I, Johnson PCD, Johnson T, Kapur K, Thorleifsson G, Strawbridge RJ, Rasmussen-Torvik LJ, Esko T, Mihailov E, Fall T, Fraser RM, Mahajan A, Kanoni S, Giedraitis V, Kleber ME, Silbernagel G, Meyer J, Müller-Nurasyid M, Ganna A, Sarin AP, Yengo L, Shungin D, Luan J, Horikoshi M, An P, Sanna S, Boettcher Y, Rayner NW, Nolte IM, Zemunik T, Iperen EV, Kovacs P, Hastie ND, Wild SH, McLachlan S, Campbell S, Polasek O, Carlson O, Egan J, Kiess W, Willemsen G, Kuusisto J, Laakso M, Dimitriou M, Hicks AA, Rauramaa R, Bandinelli S, Thorand B, Liu Y, Miljkovic I, Lind L, Doney A, Perola M, Hingorani A, Kivimaki M, Kumari M, Bennett AJ, Groves CJ, Herder C, Koistinen HA, Kinnunen L, Faire U, Bakker SJL, Uusitupa M, Palmer CNA, Jukema JW, Sattar N, Pouta A, Snieder H, Boerwinkle E, Pankow JS, Magnusson PK, Krus U, Scapoli C, de Geus EJCN, Blüher M, Wolffenbuttel BHR, Province MA, Abecasis GR, Meigs JB, Hovingh GK, Lindström J, Wilson JF, Wright AF, Dedoussis GV, Bornstein SR, Schwarz PEH, Tönjes A, Winkelmann BR, Boehm BO, März W, Metspalu A, Price JF, Deloukas P, Körner A, Lakka TA, Keinanen-Kiukaanniemi SM, Saaristo TE, Bergman RN, Tuomilehto J, Wareham NJ, Langenberg C, Männistö S, Franks PW, Hayward C, Vitart V, Kaprio J, Visvikis-Siest S, Balkau B, Altshuler D, Rudan I, Stumvoll M, Campbell H, van Duijn CM, Gieger C, Illig T, Ferrucci L, Pedersen NL, Pramstaller PP, Boehnke M, Frayling TM, Shuldiner AR, Peyser PA, Kardia SLR, Palmer LJ, Penninx BW, Meneton P, Harris TB, Navis G, Harst PV, Smith GD, Forouhi NG, Loos RJF, Salomaa V, Soranzo N, Boomsma DI, Groop L, Tuomi T, Hofman A, Munroe PB, Gudnason V, Siscovick DS, Watkins H, Lecoeur C, Vollenweider P, Franco-Cereceda A, Eriksson P, Jarvelin MR, Stefansson K, Hamsten A, Nicholson G, Karpe F, Dermitzakis ET, Lindgren CM, McCarthy MI, Froguel P, Kaakinen MA, Lyssenko V, Watanabe RM, Ingelsson E, Florez JC, Dupuis J, Barroso I, Morris AP, and Prokopenko I
Published: 2021
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