151 results on '"Fagan JJ"'
Search Results
2. Profile of paediatric tuberculosis mastoiditis - a case series
- Author
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Din, TF, Fagan, JJ, and Peer, S
- Subjects
otology ,paediatric ,mastoiditis ,TB ,tuberculosis ,tuberculosis, paediatric, mastoiditis, otology, hearing loss, TB ,hearing loss - Abstract
Background: Tuberculosis (TB) otitis media is an uncommon site of extrapulmonary TB and can primarily present as a complicated TB mastoiditis (TBM). This complication is rare in children, even in TB endemic areas but necessitates early identification as delays can lead to severe morbidities. We describe the clinical characteristics as a case series to raise awareness of the condition, and highlight fundamentals related to diagnosis and management.Methods: A retrospective chart review of clinical and radiological information of five children with TBM seen at the Red Cross War Memorial Children’s Hospital in Cape Town, South Africa, over the last 5 years. Variables collected included symptomatology, duration of disease, investigations and management.Results: All were under 5 years of age and presented with typical features of acute bacterial mastoiditis. Mean duration of symptoms was 12 days (range 3–30 days). Two children had known TB contacts. Two children had pulmonary involvement, one with miliary TB. CT of the temporal bone demonstrated extensive bony destruction of the petromastoid and demineralised ossicles in all cases. Three children had intracranial extension. Four children demonstrated hearing loss between 30 dB and 83 dB. Necrotising granulomatous inflammation was present in the mastoid specimens in all cases. Confirmatory diagnosis was made via GeneXpert polymerase chain reaction (PCR) (2), Ziehl-Nielson (ZN) stain (1) or a positive TB culture (2). Postoperatively, one patient had normal hearing, two patients had mild conductive hearing loss (CHL), one had mild-moderate CHL and one had profound hearing loss.Conclusion: Delays in identification and management result in marked bony destruction and hearing loss. Radiological and surgical findings typical of TBM, therefore, require tissue sampling from the ear for urgent microscopic, PCR and histologic testing, allowing the avoidance of a mastoidectom. In a TB endemic setting, children with typical findings and necrotising granulomatous inflammation on histology should be considered for prompt commencement of anti-TB therapy while awaiting a definitive diagnosis.
- Published
- 2022
3. IVORY Guidelines (Instructional Videos in Otorhinolaryngology by YO-IFOS): A Consensus on Surgical Videos in Ear, Nose, and Throat
- Author
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Simon, F, Peer, S, Michel, J, Bruce, IA, Cherkes, M, Denoyelle, F, Fagan, JJ, Harish, M, Hong, P, James, A, Jia, H, Krishnan, PV, Maunsell, R, Modi, VK, Nguyen, Y, Parikh, SR, Patel, N, Pullens, Bas, Russo, G, Rutter, MJ, Sargi, Z, Shaye, D, Sowerby, LJ, Yung, M, Zdanski, CJ, Teissier, N, Fakhry, N, Simon, F, Peer, S, Michel, J, Bruce, IA, Cherkes, M, Denoyelle, F, Fagan, JJ, Harish, M, Hong, P, James, A, Jia, H, Krishnan, PV, Maunsell, R, Modi, VK, Nguyen, Y, Parikh, SR, Patel, N, Pullens, Bas, Russo, G, Rutter, MJ, Sargi, Z, Shaye, D, Sowerby, LJ, Yung, M, Zdanski, CJ, Teissier, N, and Fakhry, N
- Abstract
Objectives/Hypothesis: Otolaryngology instructional videos available online are often of poor quality. The objective of this article was to establish international consensus recommendations for the production of educational surgical videos in otolaryngology. Study Design: DELPHI survey. Methods: Twenty-seven international respondents participated in this study from 12 countries. Consensus was reached after three rounds of questionnaires following the Delphi methodology. The proposals having reached the 80% agreement threshold in the third round were retained. Results: The main recommendations are as follows: 1) Ethics: patients must be anonymized and unrecognizable (apart from plastic surgery if necessary). A signed authorization must be obtained if the person is recognizable. 2) Technical aspects: videos should be edited and in high-definition (HD) quality if possible. Narration or subtitles and didactic illustrations are recommended. 3) Case presentation: name of pathology and procedure must be specified; the case should be presented with relevant workup. 4) Surgery: surgical procedures should be divided into several distinct stages and include tips and pitfalls. Pathology should be shown if relevant. Key points should be detailed at the end of the procedure. 5) Organ-specific: type of approach and bilateral audiometry should be specified in otology. Coronal plane computed tomography scans should be shown in endonasal surgery. It is recommended to show pre- and postoperative videos in voice surgery and preoperative drawings and photos of scars in plastic surgery, as well as the ventilation method in airway surgery. Conclusions: International recommendations have been determined to assist in the creation and standardization of educational surgical videos in otolaryngology and head and neck surgery. Level of Evidence: 5 Laryngoscope, 131:E732–E737, 2021.
- Published
- 2021
4. Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus
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Mehanna, H, Hardman, JC, Shenson, JA, Abou-Foul, AK, Topf, MC, AlFalasi, M, Chan, JYK, Chaturvedi, P, Chow, VLY, Dietz, A, Fagan, JJ, Godballe, C, Golusinski, W, Homma, A, Hosal, S, Iyer, NG, Kerawala, C, Koh, YW, Konney, A, Kowalski, LP, Kraus, D, Kuriakose, MA, Kyrodimos, E, Lai, SY, Leemans, CR, Lennon, P, Licitra, L, Lou, P-J, Lyons, B, Mirghani, H, Nichols, AC, Paleri, V, Panizza, BJ, Arias, PP, Patel, MR, Piazza, C, Rischin, D, Sanabria, A, Takes, RP, Thomson, DJ, Uppaluri, R, Wang, Y, Yom, SS, Zhu, Y-M, Porceddu, SV, De Almeida, JR, Simon, C, Holsinger, FC, Mehanna, H, Hardman, JC, Shenson, JA, Abou-Foul, AK, Topf, MC, AlFalasi, M, Chan, JYK, Chaturvedi, P, Chow, VLY, Dietz, A, Fagan, JJ, Godballe, C, Golusinski, W, Homma, A, Hosal, S, Iyer, NG, Kerawala, C, Koh, YW, Konney, A, Kowalski, LP, Kraus, D, Kuriakose, MA, Kyrodimos, E, Lai, SY, Leemans, CR, Lennon, P, Licitra, L, Lou, P-J, Lyons, B, Mirghani, H, Nichols, AC, Paleri, V, Panizza, BJ, Arias, PP, Patel, MR, Piazza, C, Rischin, D, Sanabria, A, Takes, RP, Thomson, DJ, Uppaluri, R, Wang, Y, Yom, SS, Zhu, Y-M, Porceddu, SV, De Almeida, JR, Simon, C, and Holsinger, FC
- Abstract
The speed and scale of the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, requiring new methods of service delivery during the health crisis. In the setting of severe resource constraint and high risk of infection to patients and clinicians, there is an urgent need to identify consensus statements on head and neck surgical oncology practice. We completed a modified Delphi consensus process of three rounds with 40 international experts in head and neck cancer surgical, radiation, and medical oncology, representing 35 international professional societies and national clinical trial groups. Endorsed by 39 societies and professional bodies, these consensus practice recommendations aim to decrease inconsistency of practice, reduce uncertainty in care, and provide reassurance for clinicians worldwide for head and neck surgical oncology in the context of the COVID-19 pandemic and in the setting of acute severe resource constraint and high risk of infection to patients and staff.
- Published
- 2020
5. A Child at the Circus
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Fagan, JJ
- Published
- 2011
6. Does sentinel lymph node biopsy have a role in nodepositive head and neck squamous carcinoma?
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Edkins, O, Hofmeyr, C, and Fagan, JJ
- Abstract
Objectives/hypothesis. The objective of the study was to determine whether sentinel lymph node biopsy (SLNB) can be used to reduce clinicaloverstaging of cervical nodes in head and neck squamous cell carcinoma (SCC) in a developing world setting.Study design. Sentinel and echelon lymph nodes were identified by means of a combination of lymphoscintigraphy, gamma probe and bluedye staining. They were analysed histologically and their pathological status was compared with the rest of the neck dissection specimen todetermine diagnostic accuracy in patients with T1-4 N0-3 SCC of the oral cavity or oropharynx undergoing primary surgical resection andneck dissection.Results. Thirty-three patients were included in the study, 13 in the node-negative (N0) and 20 in the node-positive (N+) group. In theclinically N0 group the sensitivity of SLNB was 100% and the negative predictive value (NPV) 100%. In the clinically N+ group the sensitivitywas 71% and the NPV 60% for staging the nodal status of the neck.Conclusion. The accuracy of SLNB in the clinically N+ neck is too low for SLNB to be a means of avoiding comprehensive neck dissection.Level of evidence: 2B.
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- 2013
7. Is total glossectomy for advanced caricinoma of the tongue justified?
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van Lierop, AC, Basson, O, and Fagan, JJ
- Abstract
Total glossectomy (with or without total laryngectomy) followed by postoperative radiotherapy remains the principal treatment method for advanced base of tongue carcinoma. The procedure remains controversial owing to poor cure rates and the inevitable functional deficits associated with it. However, even though total glossectomy is a major surgical procedure that impacts on speech, deglutition and quality of life, it may offer patients the best chance of cure in many centres, especially in the developing world. Methods. We did a retrospective chart review of all patients at Groote Schuur Hospital, Cape Town, who had undergone total glossectomy, with or without total laryngectomy, for stage IV squamous cell carcinoma (SCC) of the tongue between 1998 and 2004. Results. Eight patients had a total glossectomy performed during the study period. At 2, 3 and 5 years 63%, 38% and 25% of patients respectively were alive without disease. No patient required permanent nasogastric or gastrostomy feeding, and all returned to a full oral diet. Three of 5 patients who had laryngeal preservation and could be assessed for speech had intelligible speech. All but 1 patient (88%) reported pain relief following surgical excision. Perineural invasion was present in 75%, and 38% had positive resection margins. Five patients had recurrence, 2 cervical, 1 local, and 2 local and cervical. Conclusion. Advanced SCC of the tongue is a devastating disease causing severe pain and disorders of speech and swallowing. Total glossectomy (with or without total laryngectomy) and postoperative radiotherapy is a reasonable treatment option, particularly in the developing world setting. It has cure rates superior to primary radiotherapy, and provides motivated patients with excellent pain relief and a reasonable quality of life. South African Journal of Surgery Vol. 46 (1) 2008: pp. 22-25
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- 2009
8. Squamous cell caricinoma in black patients with discoid lupus erythematosus
- Author
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Mulwafu, WK, Fagan, JJ, and Jessop, S
- Abstract
Squamous cell carcinoma has rarely been reported in black African people, with only 11 cases reported in the world literature to date. We report on 2 further cases, the first to be reported in southern Africa, of squamous cell carcinoma in lesions of discoid lupus erythematosus South African Journal of Surgery Vol. 44 (4) 2006: pp. 144-146
- Published
- 2009
9. Surgical management of sialorrhoea: A review and outcome report from Red Cross Hospital, Cape Town
- Author
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Copley, GJ, Prescott, CA, and Fagan, JJ
- Abstract
Aim. To review the surgical management of sialorrhoea (submandibular duct transposition with or without bilateral excision of the sublingual salivary glands: the ‘drooling procedure\', DP) at Red Cross War Memorial Children\'s Hospital, Cape Town. Patients and methods. A retrospective review of the medical records of patients who had undergone a DP between 1996 and 2003, to ascertain the results of the procedure and complications. Subsequently a questionnaire was sent to all patients with a recognisable postal address to ascertain long-term satisfaction with the procedure. Results. Forty-six patients had had a DP, and 32 of the medical records were available for analysis. In 23 cases a comment had been recorded on the result of the procedure; 18 (78%) had shown ‘marked\' improvement and 5 (22%) ‘a little\' improvement. The medical records indicated that 2 patients had had immediate postoperative problems: one patient was slow to commence oral feeding and another required a single high dose of intravenous steroids to resolve marked oedema of the floor of the mouth. In the longer term, one patient developed a ranula (a mucus inclusion cyst). Ten postal questionnaires, were returned; of these 8 reported an improvement in the symptoms. Discussion. Short-term improvement was recorded in 78% of patients, and although only 10 questionnaires were returned, 8 of these indicated satisfaction with the procedure. It is impossible to draw conclusions, however, as the large number of patients (36 of the original 46) lost to follow-up could have had a poor outcome. There is need for prospective studies on the long-term outcome of the DP.South African Journal of Child Health Vol. 2 (2) 2008: pp. 46-49
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- 2008
10. Giant Cystic Parathyroid Adenoma Masquerading as a Retropharyngeal Abscess
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Dhirendra Govender, Fagan JJ, primary
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- 2014
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11. Buccinator myomucosal flap: clinical results and review of anatomy, surgical technique and applications.
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Van Lierop AC and Fagan JJ
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- 2008
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12. Cost of tracheoesophageal prostheses in developing countries. Facing the problem from an internal perspective.
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Staffieri A, Mostafa BE, Varghese BT, Kitcher ED, Jalisi M, Fagan JJ, Staffieri C, and Marioni G
- Abstract
Conclusions . All the discussants of our questionnaire agreed that the price of tracheoesophageal (TE) prostheses was too expensive for developing countries. The problem could be addressed in terms of international laws regarding companies' patent rights. TE prosthesis manufacturers from rich countries could move their manufacturing in part to developing countries. High production standards could allow TE prostheses to be exported to developed countries. Another approach to the problem may be based on a partnership between non-profit-making Western laryngological societies with specific medical and technical prosthetic know-how and local manufacturers. The aim of this cooperation could be the low-cost production of advanced TE prostheses in the developing countries. Objectives . In communities in the developing world, most laryngeal and hypopharyngeal carcinomas are diagnosed at advanced stages and require total laryngectomy. Prosthetic TE voice restoration is the method of choice for voice rehabilitation after total laryngectomy in developed countries. Unacceptably high costs are a significant limitation to Third World use of TE voice prostheses. The aims of this paper are to discuss the consequences of the high costs of TE prostheses in developing countries with head and neck surgeons working in Third World hospitals and to propose how European and American laryngological societies can promote TE speech in the developing countries. Material and methods . A questionnaire was given to a group of expert head and neck surgeons working in developing countries and their answers and suggestions discussed. [ABSTRACT FROM AUTHOR]
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- 2006
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13. Neurilemomas of the parapharyngeal space.
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Hamza A, Fagan JJ, Weissman JL, and Myers EN
- Published
- 1997
14. Squamous carcinoma arising in a branchial cleft cyst: have you ever treated one? Will you?
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Devaney KO, Rinaldo A, Ferlito A, Silver CE, Fagan JJ, Bradley PJ, and Suárez C
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- 2008
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15. The Global Otolaryngology-Head and Neck Surgery Workforce.
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Petrucci B, Okerosi S, Patterson RH, Hobday SB, Salano V, Waterworth CJ, Brody RM, Sprow H, Alkire BC, Fagan JJ, Tamir SO, Der C, Bhutta MF, Maina IW, Pang JC, Daudu D, Mukuzi AG, Srinivasan T, Pietrobon CA, Hao SP, Nakku D, Seguya A, Din TF, Mbougo OD, Mokoh LW, Jashek-Ahmed F, Law TJ, Holt EA, Bangesh AH, Zemene Y, Ibekwe TS, Diallo OR, Alvarado J, Mulwafu WK, Fenton JE, Agius AM, Doležal P, Mudekereza ÉA, Mojica KM, Rueda RS, and Xu MJ
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- Humans, Cross-Sectional Studies, Workforce, Surveys and Questionnaires, Head, Global Health, Otolaryngology education
- Abstract
Importance: A core component of delivering care of head and neck diseases is an adequate workforce. The World Health Organization report, Multi-Country Assessment of National Capacity to Provide Hearing Care, captured primary workforce estimates from 68 member states in 2012, noting that response rates were a limitation and that updated more comprehensive data are needed., Objective: To establish comprehensive workforce metrics for global otolaryngology-head and neck surgery (OHNS) with updated data from more countries/territories., Design, Setting, and Participants: A cross-sectional electronic survey characterizing the OHNS workforce was disseminated from February 10 to June 22, 2022, to professional society leaders, medical licensing boards, public health officials, and practicing OHNS clinicians., Main Outcome: The OHNS workforce per capita, stratified by income and region., Results: Responses were collected from 121 of 195 countries/territories (62%). Survey responses specifically reported on OHNS workforce from 114 countries/territories representing 84% of the world's population. The global OHNS clinician density was 2.19 (range, 0-61.7) OHNS clinicians per 100 000 population. The OHNS clinician density varied by World Bank income group with higher-income countries associated with a higher density of clinicians. Regionally, Europe had the highest clinician density (5.70 clinicians per 100 000 population) whereas Africa (0.18 clinicians per 100 000 population) and Southeast Asia (1.12 clinicians per 100 000 population) had the lowest. The OHNS clinicians deliver most of the surgical management of ear diseases and hearing care, rhinologic and sinus diseases, laryngeal disorders, and upper aerodigestive mucosal cancer globally., Conclusion and Relevance: This cross-sectional survey study provides a comprehensive assessment of the global OHNS workforce. These results can guide focused investment in training and policy development to address disparities in the availability of OHNS clinicians.
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- 2023
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16. Are open access article processing charges affordable for otolaryngologists in low-income and middle-income countries?
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Seguya A, Salano V, Okerosi S, Kim EK, Shrime MG, Viljoen G, and Fagan JJ
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- Humans, Otolaryngologists, Cross-Sectional Studies, Costs and Cost Analysis, Access to Information, Developing Countries
- Abstract
Purpose of Review: Open access articles are more frequently read and cited, and hence promote access to knowledge and new advances in healthcare. Unaffordability of open access article processing charges (APCs) may create a barrier to sharing research. We set out to assess the affordability of APCs and impact on publishing for otolaryngology trainees and otolaryngologists in low-income and middle-income countries (LMICs)., Recent Findings: A cross-sectional online survey was conducted among otolaryngology trainees and otolaryngologists in LMICs globally. Seventy-nine participants from 21 LMICs participated in the study, with the majority from lower middle-income status (66%). Fifty-four percent were otolaryngology lecturers while 30% were trainees. Eighty-seven percent of participants received a gross monthly salary of less than USD 1500. Fifty-two percent of trainees did not receive a salary. Ninety-one percent and 96% of all study participants believed APCs limit publication in open access journals and influence choice of journal for publication, respectively. Eighty percent and 95% believed APCs hinder career progression and impede sharing of research that influences patient care, respectively., Summary: APCs are unaffordable for LMIC otolaryngology researchers, hinder career progression and inhibit the dissemination of LMIC-specific research that can improve patient care. Novel models should be developed to support open access publishing in LMICs., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2023
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17. Human Papillomavirus-Associated Head and Neck Malignancies in Sub-Saharan Africa: A Systematic Review.
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Okerosi S, Mokoh LW, Rubagumya F, Niyibizi BA, Nkya A, Van Loon K, Buckle G, Bent S, Ha P, Fagan JJ, Ng D, Aswani J, and Xu MJ
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- United States, Humans, Human Papillomavirus Viruses, Papillomaviridae genetics, Risk Factors, Papillomavirus Infections diagnosis, Papillomavirus Infections epidemiology, Papillomavirus Infections prevention & control, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms complications
- Abstract
Purpose: The proportion of head and neck cancers (HNCs) with human papillomavirus (HPV) positivity in sub-Saharan Africa (SSA) is poorly characterized. Characterizing this has implications in staging, prognosis, resource allocation, and vaccination policies. This study aims to determine the proportion of HPV-associated HNC in SSA., Materials and Methods: This systematic review included searches from PubMed, EMBASE, Web of Science, African Index Medicus, Google Scholar, and African Journals Online. All English publications reporting the proportion of HNC specimens from SSA patients who tested positive for HPV and/or p16 were included. Study quality was assessed using the National Institutes of Health Quality Assessment Tool for Case Series Studies., Results: In this systematic review of 31 studies and 3,850 patients, the overall p16 positivity was 13.6% (41 of 1,037 patients tested) with the highest proportion among oropharyngeal cancers (20.3%, 78 of 384 patients) and the overall HPV polymerase chain reaction positivity was 15.3% (542 of 3,548 samples tested) with the highest proportion among nasopharyngeal cancers (16.5%, 23 of 139 patients). Among the 369 HPV strains detected, the most common genotypes were HPV 16 (226 patients, 59.2%) and HPV 18 (78, 20.4%)., Conclusion: HPV was found to be associated with a significant proportion of HNC in SSA. The genotypes reported suggest that the nine-valent vaccine and gender-neutral vaccination policies should be considered. Given that these studies may not accurately capture prevalence nor causation of HPV in HNC subsites, additional research is needed to provide a more thorough epidemiologic understanding of HPV-associated HNC in SSA, including risk factors and clinical outcomes.
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- 2023
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18. Management of oral feeding following total laryngectomy around the world: YO-IFOS international study.
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Benali J, Viljoen G, Ayad T, Gravier-Dumonceau R, Ceccon FP, Tangjaturonrasme N, Saibene AM, Chiesa-Estomba C, Melkane AE, Allen J, Lim CM, Mayo-Yañez M, Tucciarone M, Sargi Z, Mouawad F, Ramirez AT, Magaró M, Michel J, Radulesco T, Giovanni A, Fagan JJ, Hao SP, Lechien JR, Giorgi R, and Fakhry N
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- Humans, Laryngectomy, Pharyngectomy, Postoperative Complications, Larynx, Pharyngeal Diseases
- Abstract
Background: To analyze worldwide practices regarding the initiation of oral feeding after total laryngectomy (TL)., Methods: Online survey., Results: Among the 332 responses received, 278 from 59 countries were analyzed. Our results showed that 45.6% of respondents started water and 45.1% started liquid diet between postoperative days 7 and 10. Semi-solid feeds were initiated between days 10 and 14 for 44.9% of respondents and a free diet was allowed after day 15 for 60.8% of respondents. This timing was significantly delayed in cases of laryngo-pharyngectomy and after prior radiotherapy (p < 0.001). A greater proportion of respondents in Africa and Oceania allowed early oral feeding before day 6 as compared with the rest of the world (p < 0.001)., Conclusion: Despite increasing number of publications, there is still a lack of evidence to support early oral feeding. The majority of respondents preferred to delay its initiation until at least 7 days after surgery., (© 2022 Wiley Periodicals LLC.)
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- 2022
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19. Editorial: Otolaryngology training pathways in sub-Saharan Africa.
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Okerosi SN, Diom E, Mulwafu W, and Fagan JJ
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- Africa South of the Sahara, Humans, Nose, Pharynx, Otolaryngology
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- 2022
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20. Call for the South African Health Products Regulatory Authority to revisit regulations relating to single- use medical devices.
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Lazarus J, Maswime S, Fieggen G, Cairncross LL, Irlam J, Reed A, Peters S, and Fagan JJ
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- Humans, South Africa, Medical Device Legislation
- Published
- 2022
21. Profile of paediatric tuberculosis mastoiditis - a case series.
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Din TF, Fagan JJ, and Peer S
- Subjects
- Child, Humans, Inflammation complications, Mastoid diagnostic imaging, Mastoid surgery, Retrospective Studies, South Africa epidemiology, Hearing Loss etiology, Mastoiditis diagnosis, Mastoiditis etiology, Mastoiditis therapy, Tuberculosis complications, Tuberculosis drug therapy
- Abstract
Background: Tuberculosis (TB) otitis media is an uncommon site of extrapulmonary TB and can primarily present as a complicated TB mastoiditis (TBM). This complication is rare in children, even in TB endemic areas but necessitates early identification as delays can lead to severe morbidities. We describe the clinical characteristics as a case series to raise awareness of the condition, and highlight fundamentals related to diagnosis and management., Methods: A retrospective chart review of clinical and radiological information of five children with TBM seen at the Red Cross War Memorial Children's Hospital in Cape Town, South Africa, over the last 5 years. Variables collected included symptomatology, duration of disease, investigations and management., Results: All were under 5 years of age and presented with typical features of acute bacterial mastoiditis. Mean duration of symptoms was 12 days (range 3-30 days). Two children had known TB contacts. Two children had pulmonary involvement, one with miliary TB. CT of the temporal bone demonstrated extensive bony destruction of the petromastoid and demineralised ossicles in all cases. Three children had intracranial extension. Four children demonstrated hearing loss between 30 dB and 83 dB. Necrotising granulomatous inflammation was present in the mastoid specimens in all cases. Confirmatory diagnosis was made via GeneXpert polymerase chain reaction (PCR) (2), Ziehl-Nielson (ZN) stain (1) or a positive TB culture (2). Postoperatively, one patient had normal hearing, two patients had mild conductive hearing loss (CHL), one had mild-moderate CHL and one had profound hearing loss., Conclusion: Delays in identification and management result in marked bony destruction and hearing loss. Radiological and surgical findings typical of TBM, therefore, require tissue sampling from the ear for urgent microscopic, PCR and histologic testing, allowing the avoidance of a mastoidectom. In a TB endemic setting, children with typical findings and necrotising granulomatous inflammation on histology should be considered for prompt commencement of anti-TB therapy while awaiting a definitive diagnosis., (Copyright© Authors.)
- Published
- 2022
22. Machine Learning Algorithms as a Computer-Assisted Decision Tool for Oral Cancer Prognosis and Management Decisions: A Systematic Review.
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Chiesa-Estomba CM, Graña M, Medela A, Sistiaga-Suarez JA, Lechien JR, Calvo-Henriquez C, Mayo-Yanez M, Vaira LA, Grammatica A, Cammaroto G, Ayad T, and Fagan JJ
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- Algorithms, Artificial Intelligence, Humans, Machine Learning, Prognosis, Squamous Cell Carcinoma of Head and Neck therapy, Carcinoma, Squamous Cell therapy, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms therapy, Mouth Neoplasms diagnosis, Mouth Neoplasms therapy
- Abstract
Introduction: Despite multiple prognostic indicators described for oral cavity squamous cell carcinoma (OCSCC), its management still continues to be a matter of debate. Machine learning is a subset of artificial intelligence that enables computers to learn from historical data, gather insights, and make predictions about new data using the model learned. Therefore, it can be a potential tool in the field of head and neck cancer., Methods: We conducted a systematic review., Results: A total of 81 manuscripts were revised, and 46 studies met the inclusion criteria. Of these, 38 were excluded for the following reasons: use of a classical statistical method (N = 16), nonspecific for OCSCC (N = 15), and not being related to OCSCC survival (N = 7). In total, 8 studies were included in the final analysis., Conclusions: ML has the potential to significantly advance research in the field of OCSCC. Advantages are related to the use and training of ML models because of their capability to continue training continuously when more data become available. Future ML research will allow us to improve and democratize the application of algorithms to improve the prediction of cancer prognosis and its management worldwide., (© 2022 S. Karger AG, Basel.)
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- 2022
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23. AfHNS fellowship: Model to improve access to head and neck cancer care in Africa and developing countries.
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Fagan JJ, Otiti J, Onakoya PA, Diom E, Konney A, Gebeyehu M, Aswani J, Baidoo K, and Koch WM
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- Africa South of the Sahara, Developing Countries, Fellowships and Scholarships, Humans, Head and Neck Neoplasms therapy, Surgeons
- Abstract
Background: Head and neck cancers occur predominantly in developing countries where access to care is poor. Sub-Saharan Africa has <20 head and neck surgeons for >1 billion people and has only two fellowship training programs., Methods and Results: The AfHNS Head and Neck Fellowship is being introduced to accelerate training of African surgeons to improve access to resource appropriate cancer care. By avoiding fixed time-in-training and single training sites, training can be offered at multiple centers in Africa, even with lower patient volumes. It also creates opportunities for accredited international surgical outreach programs to contribute to training., Conclusions: Having prescribed reading and appropriate Entrustable Professional Activities that are assessed through Workplace Based Assessment, and having a summative virtual oral examination ensures that fellows are fit-for-purpose to practice in an African resource-constrained setting. Other developing countries are encouraged to adopt a similar approach to expanding head and neck cancer services., (© 2021 Wiley Periodicals LLC.)
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- 2021
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24. Letter to the Editor Response Regarding "Research Equity in Otolaryngology-Head and Neck Surgery".
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Patterson RH, Xu MJ, Okerosi S, Bhutta MF, Der C, Alkire B, Njogu R, Vendra V, Tamir SO, and Fagan JJ
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- 2021
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25. Semon Lecture: 'Laryngectomy Practice Based on Personal Research', Royal Society of Medicine, 5 November 2020, London, UK.
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Fagan JJ
- Subjects
- Biomedical Research, Cutaneous Fistula prevention & control, Enteral Nutrition methods, Health Resources, Humans, Larynx, Artificial, Neoplasm Recurrence, Local epidemiology, Organ Sparing Treatments, Otolaryngology, Pharyngeal Diseases prevention & control, Postoperative Care methods, Proton Pump Inhibitors therapeutic use, Quality of Life, Radiotherapy, Social Class, South Africa, Speech, Esophageal, Surgical Stomas, Thyroidectomy, Laryngeal Neoplasms surgery, Laryngectomy methods, Postoperative Complications prevention & control, Tracheostomy methods
- Abstract
I wish to thank the Semon Committee for inviting me to deliver the 2020 Semon lecture. This is a very special honour, as is evidenced by the list of distinguished lecturers dating back to the inaugural lecture delivered at University College London in 1913. I am not the first South African to deliver the Semon lecture, having been preceded by my previous chairman Sean Sellars in 1993, and by Jack Gluckman in 2001, who was South African raised and educated and who subsequently became the chairman of otolaryngology in Cincinnati, USA.
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- 2021
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26. Research Equity in Otolaryngology-Head and Neck Surgery.
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Patterson RH, Xu MJ, Okerosi S, Bhutta MF, Der C, Alkire B, Njogu R, Vendra V, Tamir SO, and Fagan JJ
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Equitable research collaborations benefit the quality and relevance of global otolaryngology-head and neck surgery research. However, analyses of existing global health literature have shown disproportionate representation by foreign authors. To avert this inequity and improve global otolaryngology-head and neck surgery research, we propose a framework that emphasizes local representation and capacity building in research., (© The Authors 2021.)
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- 2021
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27. Editorial: Otolaryngology education and training in the COVID-19 and post-COVID-19 digital era: a developing world perspective.
- Author
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Fagan JJ
- Subjects
- Humans, COVID-19 epidemiology, Developing Countries, Education, Distance organization & administration, Otolaryngology education
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- 2021
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28. Tracheostomy During the COVID-19 Pandemic: Comparison of International Perioperative Care Protocols and Practices in 26 Countries.
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Bier-Laning C, Cramer JD, Roy S, Palmieri PA, Amin A, Añon JM, Bonilla-Asalde CA, Bradley PJ, Chaturvedi P, Cognetti DM, Dias F, Di Stadio A, Fagan JJ, Feller-Kopman DJ, Hao SP, Kim KH, Koivunen P, Loh WS, Mansour J, Naunheim MR, Schultz MJ, Shang Y, Sirjani DB, St John MA, Tay JK, Vergez S, Weinreich HM, Wong EWY, Zenk J, Rassekh CH, and Brenner MJ
- Subjects
- COVID-19 epidemiology, COVID-19 transmission, Clinical Protocols, Humans, Practice Patterns, Physicians', COVID-19 prevention & control, Infection Control, Internationality, Perioperative Care, Tracheostomy
- Abstract
Objective: The coronavirus disease 2019 (COVID-19) pandemic has led to a global surge in critically ill patients requiring invasive mechanical ventilation, some of whom may benefit from tracheostomy. Decisions on if, when, and how to perform tracheostomy in patients with COVID-19 have major implications for patients, clinicians, and hospitals. We investigated the tracheostomy protocols and practices that institutions around the world have put into place in response to the COVID-19 pandemic., Data Sources: Protocols for tracheostomy in patients with severe acute respiratory syndrome coronavirus 2 infection from individual institutions (n = 59) were obtained from the United States and 25 other countries, including data from several low- and middle-income countries, 23 published or society-endorsed protocols, and 36 institutional protocols., Review Methods: The comparative document analysis involved cross-sectional review of institutional protocols and practices. Data sources were analyzed for timing of tracheostomy, contraindications, preoperative testing, personal protective equipment (PPE), surgical technique, and postoperative management., Conclusions: Timing of tracheostomy varied from 3 to >21 days, with over 90% of protocols recommending 14 days of intubation prior to tracheostomy. Most protocols advocate delaying tracheostomy until COVID-19 testing was negative. All protocols involved use of N95 or higher PPE. Both open and percutaneous techniques were reported. Timing of tracheostomy changes ranged from 5 to >30 days postoperatively, sometimes contingent on negative COVID-19 test results., Implications for Practice: Wide variation exists in tracheostomy protocols, reflecting geographical variation, different resource constraints, and limited data to drive evidence-based care standards. Findings presented herein may provide reference points and a framework for evolving care standards.
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- 2021
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29. The hidden curve behind COVID-19 outbreak: the impact of delay in treatment initiation in cancer patients and how to mitigate the additional risk of dying-the head and neck cancer model.
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Matos LL, Forster CHQ, Marta GN, Castro Junior G, Ridge JA, Hirata D, Miranda-Filho A, Hosny A, Sanabria A, Gregoire V, Patel SG, Fagan JJ, D'Cruz AK, Licitra L, Mehanna H, Hao SP, Psyrri A, Porceddu S, Galloway TJ, Golusinski W, Lee NY, Shiguemori EH, Matieli JE, Shiguemori APAC, Diamantino LR, Schiaveto LF, Leão L, Castro AF, Carvalho AL, and Kowalski LP
- Subjects
- Carcinoma, Squamous Cell etiology, Carcinoma, Squamous Cell mortality, Global Health, Head and Neck Neoplasms etiology, Head and Neck Neoplasms mortality, Humans, Models, Theoretical, Risk Factors, COVID-19, Carcinoma, Squamous Cell epidemiology, Delivery of Health Care, Head and Neck Neoplasms epidemiology, SARS-CoV-2, Time-to-Treatment
- Abstract
Purpose: The rapid spread of the SARS-CoV-2 pandemic around the world caused most healthcare services to turn substantial attention to treatment of these patients and also to alter the structure of healthcare systems to address an infectious disease. As a result, many cancer patients had their treatment deferred during the pandemic, increasing the time-to-treatment initiation, the number of untreated patients (which will alter the dynamics of healthcare delivery in the post-pandemic era) and increasing their risk of death. Hence, we analyzed the impact on global cancer mortality considering the decline in oncology care during the COVID-19 outbreak using head and neck cancer, a known time-dependent disease, as a model., Methods: An online practical tool capable of predicting the risk of cancer patients dying due to the COVID-19 outbreak and also useful for mitigation strategies after the peak of the pandemic has been developed, based on a mathematical model. The scenarios were estimated by information of 15 oncological services worldwide, given a perspective from the five continents and also some simulations were conducted at world demographic data., Results: The model demonstrates that the more that cancer care was maintained during the outbreak and also the more it is increased during the mitigation period, the shorter will be the recovery, lessening the additional risk of dying due to time-to-treatment initiation., Conclusions: This impact of COVID-19 pandemic on cancer patients is inevitable, but it is possible to minimize it with an effort measured by the proposed model.
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- 2021
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30. Inflammatory leiomyosarcoma of the head and neck: Case report.
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Viljoen N, Viljoen G, Fagan JJ, and Govender D
- Abstract
Introduction and Importance: Primary sarcomas in the head and neck region are rare. Inflammatory leiomyosarcoma was first described in 1995. The case reported herein is the first reported inflammatory leiomyosarcoma occurring in the head and neck., Presentation of Case: A 37-year-old male presented with a long history of an asymptomatic slowly enlarging neck mass. Examination revealed a firm mass in the lower third of the right sternocleidomastoid muscle. Computerized tomography and magnetic resonance imaging showed a lobulated, well-circumscribed tumour with malignant features. A wide local excision was performed and histopathological examination confirmed an inflammatory leiomyosarcoma., Discussion: Inflammatory leiomyosarcoma is a recently described peculiar soft tissue tumour with histological features overlapping conventional leiomyosarcoma, and dense lymphocytic inflammation and immunohistochemical reactivity for both smooth and skeletal muscle markers. These are indolent tumours and wide local excision is curative., Conclusion: This case highlights the importance of considering primary sarcomas in the differential diagnosis of asymptomatic head and neck masses., (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2021
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31. Africa: A window on challenges and opportunities for head and neck cancer.
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Fagan JJ
- Abstract
Background: Head and neck cancer occurs predominantly in the Developing World, with significant challenges relating to a high burden of disease, late presentation, and poor access to curative and palliative care., Aims: This article describes challenges relating to head and neck cancer care in Sub-Saharan Africa., Material & Methods: Educational and training innovations that have been undertaken to improve access to cancer care are presented under the following headings: Open Access Educational Resources African Head and Neck Society (AfHNS); African head and neck surgery fellowship training; AfHNS Virtual Tumor Board; The AfHNS Clinical Practice Guidelines for Head & Neck Cancers in Developing Countries and Limited Resource Settings. Concerns are also raised about universally applicable cancer staging systems., Results: The challenges facing African patients apply to equally to many other parts of the developing world., Discussion: The challenges facing African patients apply to equally to many other parts of the developing world., Conclusions: For outcomes of head and neck cancers to be improved globally, a far greater investment needs to be made in education and training to improve access to care in developing countries. To make a meaningful global impact on morbidity and mortality related to HNC, clinicians, academic institutions and professional societies in developed countries need to be sensitive to these developing world challenges and should directly engage in improving access to care through promoting open access educational resources, offering specialist and fellowship training, collaborating with appropriate research, and establishing and strengthening centers of excellence in developing countries., Level of Evidence: 2c "Outcomes research"., (© 2021 The Author. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.)
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- 2021
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32. IVORY Guidelines (Instructional Videos in Otorhinolaryngology by YO-IFOS): A Consensus on Surgical Videos in Ear, Nose, and Throat.
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Simon F, Peer S, Michel J, Bruce IA, Cherkes M, Denoyelle F, Fagan JJ, Harish M, Hong P, James A, Jia H, Krishnan PV, Maunsell R, Modi VK, Nguyen Y, Parikh SR, Patel N, Pullens B, Russo G, Rutter MJ, Sargi Z, Shaye D, Sowerby LJ, Yung M, Zdanski CJ, Teissier N, and Fakhry N
- Subjects
- Consensus, Delphi Technique, Humans, Otolaryngology education, Surveys and Questionnaires, Otolaryngology standards, Otorhinolaryngologic Surgical Procedures education, Videotape Recording standards
- Abstract
Objectives/hypothesis: Otolaryngology instructional videos available online are often of poor quality. The objective of this article was to establish international consensus recommendations for the production of educational surgical videos in otolaryngology., Study Design: DELPHI survey., Methods: Twenty-seven international respondents participated in this study from 12 countries. Consensus was reached after three rounds of questionnaires following the Delphi methodology. The proposals having reached the 80% agreement threshold in the third round were retained., Results: The main recommendations are as follows: 1) Ethics: patients must be anonymized and unrecognizable (apart from plastic surgery if necessary). A signed authorization must be obtained if the person is recognizable. 2) Technical aspects: videos should be edited and in high-definition (HD) quality if possible. Narration or subtitles and didactic illustrations are recommended. 3) Case presentation: name of pathology and procedure must be specified; the case should be presented with relevant workup. 4) Surgery: surgical procedures should be divided into several distinct stages and include tips and pitfalls. Pathology should be shown if relevant. Key points should be detailed at the end of the procedure. 5) Organ-specific: type of approach and bilateral audiometry should be specified in otology. Coronal plane computed tomography scans should be shown in endonasal surgery. It is recommended to show pre- and postoperative videos in voice surgery and preoperative drawings and photos of scars in plastic surgery, as well as the ventilation method in airway surgery., Conclusions: International recommendations have been determined to assist in the creation and standardization of educational surgical videos in otolaryngology and head and neck surgery., Level of Evidence: 5 Laryngoscope, 131:E732-E737, 2021., (© 2020 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA).)
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- 2021
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33. Making the Best of Limited Resources: Improving Outcomes in Head and Neck Cancer.
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Fagan JJ, Noronha V, and Graboyes EM
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- Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms mortality, Health Priorities, Health Services Needs and Demand, Humans, Needs Assessment, Treatment Outcome, COVID-19, Head and Neck Neoplasms therapy, Health Services Accessibility, Medical Oncology
- Abstract
The overwhelming majority of head and neck cancers and related deaths occur in low- and middle-income countries, which have challenges related to burden of disease versus access to care. Yet the additional health care burden of the COVID-19 pandemic has also impacted access to care for patients with head and neck cancer in the United States. This article focuses on challenges and innovation in prioritizing head and neck cancer care in Sub-Saharan Africa, the Indian experience of value-added head and neck cancer care in busy and densely populated regions, and strategies to optimize the management of head and neck cancer in the United States during the COVID-19 pandemic.
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- 2021
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34. General Medical Council report exposes unethical recruitment of doctors in the UK from low-resource countries.
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Fagan JJ and Bhutta MF
- Subjects
- Education, Medical, Humans, United Kingdom, Foreign Medical Graduates supply & distribution, Personnel Selection ethics, Physicians supply & distribution
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- 2020
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35. Does thyroid-sparing total laryngectomy decrease the risk of hypothyroidism?
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Viljoen G, McGuire JK, Alhadad A, Dalvie S, and Fagan JJ
- Subjects
- Aged, Cross-Sectional Studies, Female, Humans, Hypothyroidism epidemiology, Incidence, Laryngeal Neoplasms pathology, Laryngectomy methods, Male, Middle Aged, Organ Sparing Treatments methods, Organ Sparing Treatments statistics & numerical data, Postoperative Complications epidemiology, Radiotherapy, Adjuvant methods, Retrospective Studies, Risk Reduction Behavior, South Africa epidemiology, Thyroidectomy adverse effects, Thyroidectomy trends, Hypothyroidism prevention & control, Laryngeal Neoplasms surgery, Laryngectomy adverse effects, Thyroid Gland surgery, Thyroidectomy methods
- Abstract
Background: Thyroid lobectomy is recommended with total laryngectomy for laryngeal cancer in the National Comprehensive Cancer Network ('NCCN') guidelines. However, it is associated with a 32-89 per cent risk of hypothyroidism, with or without adjuvant radiotherapy., Objective: The study aimed to determine whether preserving the whole thyroid, compared to a single lobe, does indeed significantly lower the incidence of hypothyroidism in the setting of total laryngectomy., Method: A retrospective study was conducted at Groote Schuur Hospital in Cape Town, South Africa., Results: Eighty-four patients met the inclusion criteria. The overall incidence of hypothyroidism was 45.2 per cent. The incidence of hypothyroidism was significantly reduced in patients who underwent thyroid-sparing total laryngectomy compared to hemithyroidectomy (p = 0.037). Adjuvant radiotherapy was associated with a higher incidence of hypothyroidism (p = 0.001)., Conclusion: Thyroid-preserving laryngectomy should be advocated in carefully selected patients with advanced laryngeal carcinoma, as it reduces the incidence of hypothyroidism.
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- 2020
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36. The role of the University of Cape Town, South Africa in the training and retention of surgeons in Sub-Saharan Africa.
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Naidu P, Fagan JJ, Lategan C, Devenish LP, and Chu KM
- Subjects
- Africa South of the Sahara, Cross-Sectional Studies, Female, Health Workforce, Humans, Male, Retrospective Studies, Surveys and Questionnaires, Fellowships and Scholarships, Foreign Medical Graduates statistics & numerical data, Internship and Residency, Surgeons supply & distribution, Universities
- Abstract
Background: Sub-Saharan Africa (SSA) has a shortage of surgeon specialists. Many SSA countries lack specialty training programs but South Africa, an upper middle-income country, has several post-graduate surgical training programs. The primary objective of this study was to describe the retention rates of non-South African SSA surgical trainees from the University of Cape Town (UCT) on the African sub-continent. The secondary objective was to describe advantages and disadvantages of foreign surgical trainees on the UCT surgical training programs., Methods: This was a two-part cross-sectional survey administered via email between June 1, 2018 and March 1, 2019 to UCT 1) surgical residents and fellows who graduated between 2007 and 2017 and whose country of origin was in SSA but outside South Africa, and 2) UCT surgical division heads., Results: Thirty out of 78 (38%) trainees responded; 83% (n = 25) were male. There was a 96% retention rate of surgical trainees in SSA, 80% (n = 24) returned to their country of origin after training, 83% (n = 25) worked in the public sector, and 90% (n = 27) in teaching hospitals. Seven out of ten surgical division heads responded. Reported advantages of SSA trainees included more junior staff (n = 5, 71%) and the establishment of SSA networks (n = 4, 57%). Disadvantages included increased training responsibilities for educators (n = 2, 29%) and fewer cases for South African trainees (n = 2, 29%)., Discussion: Retention on the African sub-continent of surgeons who trained at UCT was high. SSA doctors can utilize South African post-graduate surgical training programs until their own countries increase their training capacity. The majority of trainees returned to their countries of origin, utilizing their skills in the public and academic sectors, and contributing to the teaching of more trainees. These training partnerships also contribute to knowledge-sharing and facilitate a regional network of African surgeons. Active recruitment of more female trainees is needed to ensure gender equity., Competing Interests: Declaration of competing interest Authors declared they have no conflicts of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (Copyright © 2020 Elsevier Inc. All rights reserved.)
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- 2020
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37. The assessment of quality of life in children with tracheostomies and their families in a low to middle income country (LMIC).
- Author
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Din TF, McGuire J, Booth J, Lytwynchuk A, Fagan JJ, and Peer S
- Subjects
- Caregivers, Child, Developing Countries, Health Status, Humans, South Africa, Quality of Life, Tracheostomy
- Abstract
Introduction: The Breatheasy© Tracheostomy Program based at the Red Cross War Memorial Children's Hospital, Cape Town, manages children mostly from poor socio-economic backgrounds. In our resource-limited setting, it is unclear how these families cope with the demands of a tracheostomised child. We aim to assess the quality of life (QOL) of tracheostomised children and their families as the first study of its kind in a low-resource setting., Methods: A descriptive, observational study was done to assess the QOL of tracheostomised children managed by the Breatheasy© Program over 10 months. Children with tracheostomies for longer than 6 months, complex syndromic children, and home ventilated children were included. The validated Paediatric Tracheotomy Health Status Instrument (PTHSI) was utilised, where a higher score implied a better outcome., Results: A total of 68 families were recruited. In 57 (85.1%) of the carers, the highest level of education achieved was primary or high school. Twenty-seven (42%) families reported having an annual household income of less than $675 US Dollars (
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- 2020
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38. African Head and Neck Society Clinical Practice guidelines for thyroid nodules and cancer in developing countries and limited resource settings.
- Author
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Zafereo M, Yu J, Onakoya PA, Aswani J, Baidoo K, Bogale M, Cairncross L, Cordes S, Daniel A, Diom E, Maurice ME, Mohammed GM, Biadgelign MG, Koné FI, Itiere A, Koch W, Konney A, Kundiona I, Macharia C, Mashamba V, Moore MG, Mugabo RM, Noah P, Omutsani M, Orloff LA, Otiti J, Randolph GW, Sebelik M, Todsen T, Twier K, and Fagan JJ
- Subjects
- Developing Countries, Humans, Neck, United States, Thyroid Neoplasms diagnosis, Thyroid Neoplasms therapy, Thyroid Nodule diagnosis, Thyroid Nodule therapy
- Abstract
Background: International thyroid nodule and cancer management guidelines generally fail to take into account potential limitations in diagnostic and treatment resources., Methods: Thyroid cancer specialists from the African Head and Neck Society and American Head & Neck Society Endocrine Section developed guidelines for diagnosis and management of thyroid nodules and cancer in low resource settings. Recommendations were based on literature review and expert opinion, with level of evidence defined., Results: Using the ADAPTE process, diagnostic and treatment algorithms were adapted from the National Comprehensive Cancer Network (NCCN). Low resource settings were simulated by systematically removing elements such as availability of laboratory testing, hormone replacement, imaging, and cytopathology from NCCN guidelines., Conclusions: Successful management of thyroid nodules and cancer in low resource settings requires adaptation of treatment methodologies. These guidelines define specific scenarios where either more or less aggressive intervention for thyroid pathology may be advisable based on limited available resources., (© 2020 The Authors. Head & Neck published by Wiley Periodicals, Inc.)
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- 2020
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39. Fine-needle aspiration cytology of head and neck masses: Is ultrasound guidance routinely warranted?
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Viljoen G, Viljoen N, Bolding E, and Fagan JJ
- Subjects
- Humans, Resource Allocation, Retrospective Studies, South Africa, Biopsy, Fine-Needle, Head and Neck Neoplasms pathology, Image-Guided Biopsy, Lymph Nodes pathology, Palpation, Ultrasonography, Interventional
- Published
- 2020
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40. Is AJCC/UICC Staging Still Appropriate for Head and Neck Cancers in Developing Countries?
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Fagan JJ, Wetter J, Otiti J, Aswani J, Konney A, Diom E, Baidoo K, Onakoya P, Mugabo R, Noah P, Mashamba V, Kundiona I, Macharia C, Mainasara MG, Gebeyehu M, Bogale M, Twier K, Faniriko M, Melesse GB, and Shrime MG
- Abstract
By 2030, 70% of cancers will occur in developing countries. Head and neck cancers are primarily a developing world disease. While anatomical location and the extent of cancers are central to defining prognosis and staging, the American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) have incorporated nonanatomic factors that correlate with prognosis into staging (eg, p16 status of oropharyngeal cancers). However, 16 of 17 head and neck surgeons from 13 African countries cannot routinely test for p16 status and hence can no longer apply AJCC/UICC staging to oropharyngeal cancer. While the AJCC/UICC should continue to refine staging that best reflects treatment outcomes and prognosis by incorporating new nonanatomical factors, they should also retain and refine anatomically based staging to serve the needs of clinicians and their patients in resource-constrained settings. Not to do so would diminish their global relevance and in so doing also disadvantage most of the world's cancer patients., (© The Authors 2020.)
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- 2020
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41. Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus.
- Author
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Mehanna H, Hardman JC, Shenson JA, Abou-Foul AK, Topf MC, AlFalasi M, Chan JYK, Chaturvedi P, Chow VLY, Dietz A, Fagan JJ, Godballe C, Golusiński W, Homma A, Hosal S, Iyer NG, Kerawala C, Koh YW, Konney A, Kowalski LP, Kraus D, Kuriakose MA, Kyrodimos E, Lai SY, Leemans CR, Lennon P, Licitra L, Lou PJ, Lyons B, Mirghani H, Nichols AC, Paleri V, Panizza BJ, Parente Arias P, Patel MR, Piazza C, Rischin D, Sanabria A, Takes RP, Thomson DJ, Uppaluri R, Wang Y, Yom SS, Zhu YM, Porceddu SV, de Almeida JR, Simon C, and Holsinger FC
- Subjects
- Betacoronavirus, COVID-19, Consensus, Coronavirus Infections prevention & control, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms pathology, Humans, International Cooperation, Occupational Health, Pandemics prevention & control, Patient Safety, Pneumonia, Viral prevention & control, SARS-CoV-2, Surgical Oncology organization & administration, Coronavirus Infections epidemiology, Head and Neck Neoplasms surgery, Health Care Rationing, Pneumonia, Viral epidemiology, Practice Guidelines as Topic, Surgical Oncology standards
- Abstract
The speed and scale of the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, requiring new methods of service delivery during the health crisis. In the setting of severe resource constraint and high risk of infection to patients and clinicians, there is an urgent need to identify consensus statements on head and neck surgical oncology practice. We completed a modified Delphi consensus process of three rounds with 40 international experts in head and neck cancer surgical, radiation, and medical oncology, representing 35 international professional societies and national clinical trial groups. Endorsed by 39 societies and professional bodies, these consensus practice recommendations aim to decrease inconsistency of practice, reduce uncertainty in care, and provide reassurance for clinicians worldwide for head and neck surgical oncology in the context of the COVID-19 pandemic and in the setting of acute severe resource constraint and high risk of infection to patients and staff., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
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- 2020
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42. COVID-19: UCT-Africa Virtual ENT transcends academic silos through videoconferencing academic meetings and ward rounds.
- Author
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Goncalves N, Din TF, and Fagan JJ
- Subjects
- Access to Information, Betacoronavirus, COVID-19, Humans, Internet, Otolaryngology organization & administration, SARS-CoV-2, South Africa, Congresses as Topic, Coronavirus Infections, Otolaryngology education, Pandemics, Pneumonia, Viral, Teaching Rounds, Videoconferencing
- Published
- 2020
43. Reintroduction of elective paediatric otolaryngology procedures in South Africa during the COVID-19 pandemic.
- Author
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McGuire JK, Fagan JJ, and Peer S
- Subjects
- Adult, COVID-19, Child, Child, Preschool, Coronavirus Infections prevention & control, Developing Countries, Elective Surgical Procedures standards, Female, Humans, Male, Organizational Innovation, Otorhinolaryngologic Surgical Procedures statistics & numerical data, Outcome Assessment, Health Care, Pandemics prevention & control, Patient Selection, Pneumonia, Viral prevention & control, Public Health, South Africa, Coronavirus Infections epidemiology, Elective Surgical Procedures statistics & numerical data, Infection Control methods, Otorhinolaryngologic Surgical Procedures standards, Pandemics statistics & numerical data, Pneumonia, Viral epidemiology, Practice Guidelines as Topic
- Abstract
Cancelling elective clinical consultations and surgical procedures was instrumental in assisting hospitals prepare for the COVID-19 crisis. Essential bed space was made available, and it allowed mobilisation of health workers and enforced social distancing. A shift in patient-centred ethics to public health ethics was required to provide a utilitarian approach to the crisis. However, at some point, clinicians need to start becoming patient centred again, and this needs to happen within the utilitarian framework. Children only account for 1 - 5% of confirmed COVID-19 cases, and they present with a much milder disease spectrum than adults. Consequently, paediatric units may be at the forefront of implementing reintroduction of patient-centred elective clinical and surgical procedures. The following recommendations provide a framework to do this in a way that minimises risk to patients and clinicians. They are the first paediatric guidelines in the literature to propose a strategy to reintroduce elective surgical procedures.
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- 2020
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44. Does Thyroid Gland Preserving Total Laryngectomy Affect Oncological Control in Laryngeal Carcinoma?
- Author
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McGuire JK, Viljoen G, Rocke J, Fitzpatrick S, Dalvie S, and Fagan JJ
- Subjects
- Aged, Disease-Free Survival, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local epidemiology, Retrospective Studies, Thyroidectomy, Treatment Outcome, Laryngeal Neoplasms surgery, Laryngectomy methods, Organ Sparing Treatments, Thyroid Gland
- Abstract
Introduction: Thyroid lobectomy is recommended with total laryngectomy in the National Comprehensive Cancer Network guidelines. However, it is associated with a 32% to 89% risk of hypothyroidism, which is a problem for patients without access to thyroid hormone monitoring and replacement. A number of studies have reported a low incidence of thyroid gland involvement and recommended preserving the thyroid gland in favorable cases. Yet there are no studies that report whether thyroid preserving laryngectomy for laryngeal cancer adversely affects oncologic outcomes compared to patients who have undergone thyroid lobectomy., Objectives: To determine whether patients who underwent thyroid gland preserving laryngectomy had higher local recurrence rates or poorer disease-free survival., Method: A retrospective folder review of patients who underwent a total laryngectomy over a 12-year period was conducted. Local recurrence and disease-free survival were determined for patients who had both their thyroid lobes preserved and compared with those who had a thyroid lobectomy., Results: Sixty-nine patients had thyroid preserving laryngectomy and 73 patients had a thyroid lobectomy. The duration of follow-up was 18 to 132 months (median, 30; IQR, 30). There was no significant difference in local recurrence rates (P = .76) or survival curves between the two groups., Conclusion: Thyroid preserving laryngectomy in selected patients with advanced laryngeal carcinoma does not increase local recurrence rates, nor does it negatively affect disease-free survival. Thyroid preservation is appropriate when intraoperative inspection of the larynx shows no extralaryngeal extension or when paratracheal nodal metastases are not a concern., Level of Evidence: Level 4 Laryngoscope, 130:1465-1469, 2020., (© 2019 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2020
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45. Editorial: Developing world perspectives in otolaryngology: infectious complications in otolaryngology.
- Author
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Fagan JJ
- Subjects
- Humans, Infections diagnosis, Infections economics, Infections etiology, Otolaryngology economics, Otorhinolaryngologic Diseases complications, Otorhinolaryngologic Diseases diagnosis, Otorhinolaryngologic Diseases economics, Developing Countries economics, Infections therapy, Otorhinolaryngologic Diseases therapy
- Published
- 2020
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46. How should health resource allocation be applied during the COVID-19 pandemic in South Africa?
- Author
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Taylor A, Taylor B, Parkes J, and Fagan JJ
- Subjects
- COVID-19, Coronavirus Infections economics, Coronavirus Infections epidemiology, Developing Countries, Female, Humans, Male, Pandemics economics, Pneumonia, Viral economics, Pneumonia, Viral epidemiology, South Africa, Coronavirus Infections prevention & control, Health Resources economics, Pandemics prevention & control, Pneumonia, Viral prevention & control, Poverty economics, Resource Allocation organization & administration
- Published
- 2020
47. COVID-19 exposes health worker shortages in the USA and UK, but nationalism and self-interest must not exploit medical workforces from low- and middle-income countries.
- Author
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Fagan JJ, Cairncross L, Biccard B, Fieggen G, and Maswime S
- Subjects
- Betacoronavirus isolation & purification, COVID-19, Developing Countries, Health Services Accessibility trends, Health Services Needs and Demand trends, Humans, SARS-CoV-2, United Kingdom, United States, Coronavirus Infections epidemiology, Foreign Medical Graduates ethics, Foreign Medical Graduates supply & distribution, Foreign Medical Graduates trends, Health Personnel classification, Health Personnel ethics, Health Workforce ethics, Health Workforce trends, Pandemics, Pneumonia, Viral epidemiology
- Published
- 2020
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48. Global Burden of Head and Neck Cancer: Economic Consequences, Health, and the Role of Surgery.
- Author
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Patterson RH, Fischman VG, Wasserman I, Siu J, Shrime MG, Fagan JJ, Koch W, and Alkire BC
- Subjects
- Female, Humans, Incidence, Male, Cost of Illness, Global Health, Head and Neck Neoplasms economics, Head and Neck Neoplasms mortality, Head and Neck Neoplasms surgery
- Abstract
Objective: We aimed to describe the mortality burden and macroeconomic effects of head and neck cancer as well as delineate the role of surgical workforce in improving head and neck cancer outcomes., Study Design: Statistical and economic analysis., Setting: Research group., Subjects and Methods: We conducted a statistical analysis on data from the World Development Indicators and the 2016 Global Burden of Disease study to describe the relationship between surgical workforce and global head and neck cancer mortality-to-incidence ratios. A value of lost output model was used to project the global macroeconomic effects of head and neck cancer., Results: Significant differences in mortality-to-incidence ratios existed between Global Burden of Disease study superregions. An increase of surgical, anesthetic, and obstetric provider density by 10% significantly correlated with a reduction of 0.76% in mortality-to-incidence ratio ( P < .0001; adjusted R
2 = 0.84). There will be a projected global cumulative loss of $535 billion US dollars (USD) in economic output due to head and neck cancer between 2018 and 2030. Southeast Asia, East Asia, and Oceania will suffer the greatest gross domestic product (GDP) losses at $180 billion USD, and South Asia will lose $133 billion USD., Conclusion: The mortality burden of head and neck cancer is increasing and disproportionately affects those in low- and middle-income countries and regions with limited surgical workforces. This imbalance results in large and growing economic losses in countries that already face significant resource constraints. Urgent investment in the surgical workforce is necessary to ensure access to timely surgical services and reverse these negative trends.- Published
- 2020
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49. Systematic review of international guidelines for perioperative antibiotic prophylaxis in Head & Neck Surgery. A YO-IFOS Head & Neck Study Group Position Paper.
- Author
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Chiesa-Estomba CM, Lechien JR, Fakhry N, Melkane A, Calvo-Henriquez C, de Siati D, Gonzalez-Garcia JA, Fagan JJ, and Ayad T
- Subjects
- Humans, Practice Guidelines as Topic, Surgical Wound Infection epidemiology, Antibiotic Prophylaxis, Head and Neck Neoplasms surgery, Surgical Wound Infection prevention & control
- Abstract
Background: Surgical site infection (SSI) is defined as an infection that occurs after a surgical incision or organ manipulation during surgery. The frequency reported for clean head and neck surgical procedures without antimicrobial prophylaxis is <1%. In contrast, infection rates in patients undergoing complicated cancer surgery are high, ranging from 24% to 87% of patients without antimicrobial prophylaxis., Methods: Guidelines and recommendations about the use of antibiotics in head and neck surgery from 2004 to 2019 were reviewed., Results: Four guidelines from Oceania, 5 from South America, 5 from North America, 2 from the United Kingdom, 11 from Europe, 1 from Africa, 1 from the Middle East, and 3 from Asia were included. A total of 118 papers were included for analysis and recommendation., Conclusion: Antibiotic prophylaxis can decrease the incidence of SSI. However, the risks associated with antibiotic exposure and the risk of antibiotic resistance need to be taken into consideration., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF
50. Open Access Publishing of Textbooks and Guidelines for Otolaryngologists in Developing Countries.
- Author
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Fagan JJ
- Abstract
Accessing educational and scientific material is key to improving otolaryngology care in developing countries. Yet current financial models of publishers restrict access to academic information. This article describes the author's experience with self-publishing 2 open access textbooks, Open Access Atlas of Otolaryngology, Head and Neck Operative Surgery and Open Access Guide to Audiology and Hearing Aids for Otolaryngologists , as well as the African Head and Neck Society (AfHNS) Clinical Practice Guidelines for Head and Neck Cancer in Developing Countries and Limited Resource Settings . The author outlines the simplicity, advantages, and popularity of this form of publication and why societies and individuals should embrace open access publishing to benefit especially those studying and practicing in developing countries. He discusses some of the challenges related to open access publishing and calls for medical societies to become involved in evaluating the quality of open access texts and videos for their members.
- Published
- 2019
- Full Text
- View/download PDF
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