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Myocardial ischemia–reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium due to ischemia–reperfusion includes cardiac contractile dysfunction, arrhythmias as well as irreversible myocytes damage. A total of 24 Swiss albino adult male mice were randomized into 4 equal groups. Group (1) sham group; Group (2) control group; Group (3) control vehicle (DMSO) group; Group (4) Ferulic acid treated group. Results of this study showed that levels of myocardial IL-6, were increased (p

Background: Myocardial ischemia–reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Angiotensin II may contribute to reperfusion injury by increasing oxidative stress and inflammatory factors . Ang II exerts most of its effects via AT1Rs. Apoptosis of cardiomyocytes may further be influenced by Ang II. Objective: This study was undertaken to investigate the potential role of Telmisartan in amelioration of myocardial I/R injury induced by ligation of coronary artery in mouse model. Materials & method: Adult male Swiss-albino mice were randomized into 4 equal groups. Group (1) sham group: Mice underwent the same anesthetic and surgical procedure as the active control group except ligation of LAD coronary artery.Group( 2) active control group: Mice were subjected to regional ischemia for 30 min by ligation of LAD coronary artery and reperfusion for 2 hours .Group( 3) control vehicle group (1): Mice in this group injected with DMSO (vehicle for Telmisartan ) via IP route & underwent Myocardial ischemia for 30 minutes by ligation of (LAD) coronary artery & reperfusion for 2 hr . Group (4)Telmisartan treated group : Mice pretreated with Telmisartan 0.5mg/kg i.p 30 minutesbefore ligation of LAD coronary artery. Results: Compared with the sham group, Levels of TNF-α & IL-1β, IL-6,caspase 3 and plasma level of cardiac troponin I increased in control group (p

Ischemia/reperfusion injury describes the experimentally and clinically prevalent finding that tissue ischemia with inadequate oxygen followed by successful reperfusion initiates a wide and complex array of inflammatory responses that may aggravate local injury as well as induce impairment of remote organ function by mechanisms that involves oxidative stress, inflammation, and apoptosis. In this study, we investigated the cardio protective effects of Valsartan in regional ischemia/ reperfusion injury. adult male Albino rats were randomized into 4 equal groups. Group (1) sham group: rats underwent the same anesthetic and surgical procedure as the control group except ligation of LAD coronary artery , Group( 2) control group: rats subjected to regional ischemia for 25 min by ligation of LAD coronary artery and reperfusion for 2 hours ,Group( 3) control vehicle group: rats received (normal saline) vehicle of valsartan via I.P injection and subjected to regional ischemia for 25 min and reperfusion for 2 hours , Group( 4) valsartan treated group : rats pretreated with valsartan 10mg/kg I.P 30 minutes before ligation of LAD coronary artery then subjected to the surgical procedure with ligation of LAD for 30 minutes followed by 120 minutes reperfusion. At the end of reperfusion, Heart was divided into two parts, the apex for histopathology and the remaining part used for determination of tissue TNF-α,and IL-6 It has been found that Valsartan treated group showed significant reduction (P˂0.05) in TNFα with respect to the control groups.Histopathology study revealed that the treatment with Valsartan significantly (P˂0.05) improved cardiac injury as compared with control groups, we concluded that Valsartan reduces inflammatory reaction associated with ischemia/reperfusion injury induced by LAD ligation in addition to its reduction for cardiac injury induced by ischemia reperfusion.

Background: Myocardial ischemia–reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium due to ischemia–reperfusion includes cardiac contractile dysfunction, arrhythmias as well as irreversible myocytes damage. Objective: This study was undertaken to investigate the potential role of simvastatin in amelioration of myocardial I/R injury induced by ligation of coronary artery in a rat model. Materials & methods: adult male Swiss Albino rats were randomized into 4 equal groups. Group (I) sham group: rats underwent the same anesthetic and surgical procedure as the control group except ligation of LAD coronary artery , Group(II) control group: rats subjected to regional ischemia for 25 min by ligation of LAD coronary artery and reperfusion for 2 hours ,Group(III ) control vehicle group: rats received vehicle of simvastatin (normal saline) via I.P injection and subjected to regional ischemia for 25 min by ligation of LAD coronary artery and reperfusion for 2 hours , Group(IV) simvastatin treated group :rats pretreated with simvastatin 1mg/kg i.p 1 hr before ligation of LAD coronary artery. At the end of experiment (2 hr of reperfusion), the heart was harvested and the part of the heart just below the site of ligation was divided into two parts ,the upper part was homogenized for the measurement of interleukin-1β (IL-1β) and the lower part of tissues fixed in 10% formalin and embedded in paraffin the sections were stained with hematoxylin and eosin (H&E) then used for histopathological study . Results: Compared with the sham group, levels of myocardial IL-1β, were increased (p