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471 results on '"Fadda, Paolo"'

2. Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits

Author

Alves, Michele Joana, Browe, Brigitte M, Carolina Rodrigues Dias, Ana, Torres, Juliet M, Zaza, Giuliana, Bangudi, Suzy, Blackburn, Jessica, Wang, Wesley, de Araujo Fernandes- Junior, Silvio, Fadda, Paolo, Toland, Amanda, Baer, Lisa A., Stanford, Kristin I., Czeisler, Catherine, Garcia, Alfredo J, III, and Javier Otero, José

Published
2024
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4. Author Correction: Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes

Author

Lehman, Norman L., Spassky, Nathalie, Sak, Müge, Webb, Amy, Zumbar, Cory T., Usubalieva, Aisulu, Alkhateeb, Khaled J., McElroy, Joseph P., Maclean, Kirsteen H., Fadda, Paolo, Liu, Tom, Gangalapudi, Vineela, Carver, Jamie, Abdullaev, Zied, Timmers, Cynthia, Parker, John R., Pierson, Christopher R., Mobley, Bret C., Gokden, Murat, Hattab, Eyas M., Parrett, Timothy, Cooke, Ralph X., Lehman, Trang D., Costinean, Stefan, Parwani, Anil, Williams, Brian J., Jensen, Randy L., Aldape, Kenneth, and Mistry, Akshitkumar M.

Published
2023
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6. Port Clusters as an Opportunity for Optimizing Small-Scale LNG Distribution Chains: An Application to the Mediterranean Case

Author

Serra, Patrizia, Mancini, Simona, Fancello, Gianfranco, Sollai, Federico, Fadda, Paolo, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Rocha, Ana Maria A. C., editor, and Garau, Chiara, editor

Published
2022
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8. Association of ESR1 germline variants with TP53 somatic variants in breast tumors in a genome-wide study

Author

Tjader, Nijole P., primary, Beer, Abigail J., additional, Ramroop, Johnny, additional, Tai, Mei-Chee, additional, Ping, Jie, additional, Gandhi, Tanish, additional, Dauch, Cara, additional, Neuhausen, Susan L., additional, Ziv, Elad, additional, Sotelo, Nereida, additional, Ghanekar, Shreya, additional, Meadows, Owen, additional, Paredes, Monica, additional, Gillespie, Jessica L., additional, Aeilts, Amber M., additional, Hampel, Heather, additional, Zheng, Wei, additional, Jia, Guochong, additional, Hu, Qiang, additional, Wei, Lei, additional, Liu, Song, additional, Ambrosone, Christine B., additional, Palmer, Julie R., additional, Carpten, John D., additional, Yao, Song, additional, Stevens, Patrick, additional, Ho, Weang-Kee, additional, Pan, Jia Wern, additional, Fadda, Paolo, additional, Huo, Dezheng, additional, Teo, Soo Hwang, additional, McElroy, Joseph Paul, additional, and Toland, Amanda E., additional

Published
2024
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9. Molecular profiling of kidney compartments from serial biopsies differentiate treatment responders from non-responders in lupus nephritis

Author

Parikh, Samir V., Malvar, Ana, Song, Huijuan, Shapiro, John, Mejia-Vilet, Juan Manuel, Ayoub, Isabelle, Almaani, Salem, Madhavan, Sethu, Alberton, Valeria, Besso, Celeste, Lococo, Bruno, Satoskar, Anjali, Zhang, Jianying, Yu, Lianbo, Fadda, Paolo, Eadon, Michael, Birmingham, Dan, Ganesan, Latha P., Jarjour, Wael, and Rovin, Brad H.

Published
2022
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11. Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes

Author

Lehman, Norman L., Spassky, Nathalie, Sak, Müge, Webb, Amy, Zumbar, Cory T., Usubalieva, Aisulu, Alkhateeb, Khaled J., McElroy, Joseph P., Maclean, Kirsteen H., Fadda, Paolo, Liu, Tom, Gangalapudi, Vineela, Carver, Jamie, Abdullaev, Zied, Timmers, Cynthia, Parker, John R., Pierson, Christopher R., Mobley, Bret C., Gokden, Murat, Hattab, Eyas M., Parrett, Timothy, Cooke, Ralph X., Lehman, Trang D., Costinean, Stefan, Parwani, Anil, Williams, Brian J., Jensen, Randy L., Aldape, Kenneth, and Mistry, Akshitkumar M.

Published
2022
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14. Decision-Making for Maritime Networks: Evaluating Corporate and Social Profitability of an Integrated Short Sea Shipping Network in the Upper Tyrrhenian Sea

Author

Fancello, Gianfranco, Serra, Patrizia, Carta, Michele, Aramu, Valentina, Fadda, Paolo, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Garau, Chiara, editor, Blečić, Ivan, editor, Taniar, David, editor, Apduhan, Bernady O., editor, Rocha, Ana Maria A. C., editor, Tarantino, Eufemia, editor, Torre, Carmelo Maria, editor, and Karaca, Yeliz, editor

Published
2020
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15. Processes for Noise Reduction in Urban Port Fronts

Author

Sollai, Federico, Baccoli, Roberto, Medda, Andrea, Fancello, Gianfranco, Serra, Patrizia, Fadda, Paolo, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Garau, Chiara, editor, Blečić, Ivan, editor, Taniar, David, editor, Apduhan, Bernady O., editor, Rocha, Ana Maria A. C., editor, Tarantino, Eufemia, editor, Torre, Carmelo Maria, editor, and Karaca, Yeliz, editor

Published
2020
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16. Treatment of Port Wastes According to the Paradigm of the Circular Economy

Author

Fadda, Paolo, Viola, Antonio, Carta, Michele, Secci, Debora, Fancello, Gianfranco, Serra, Patrizia, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Garau, Chiara, editor, Blečić, Ivan, editor, Taniar, David, editor, Apduhan, Bernady O., editor, Rocha, Ana Maria A. C., editor, Tarantino, Eufemia, editor, Torre, Carmelo Maria, editor, and Karaca, Yeliz, editor

Published
2020
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19. MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia

Author

Rassenti, Laura Z, Balatti, Veronica, Ghia, Emanuela M, Palamarchuk, Alexey, Tomasello, Luisa, Fadda, Paolo, Pekarsky, Yuri, Widhopf, George F, Kipps, Thomas J, and Croce, Carlo M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Lymphoma, Biotechnology, Cancer, Rare Diseases, Clinical Research, Hematology, 2.1 Biological and endogenous factors, Aetiology, Antibodies, Monoclonal, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Bridged Bicyclo Compounds, Heterocyclic, Cohort Studies, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, MicroRNAs, Proto-Oncogene Proteins c-bcl-2, Receptor Tyrosine Kinase-like Orphan Receptors, Sulfonamides, Tumor Cells, Cultured, CLL, ROR1, miR-15/16, Blc2, venetoclax
Abstract

Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax fails to eradicate minimal residual disease in most patients. Accordingly, we were interested in other genes that may be regulated by miR-15/16, which may target other drivers in CLL. We found that miR-15/16 targets ROR1, which encodes an onco-embryonic surface protein expressed on the CLL cells of over 90% of patients, but not on virtually all normal postpartum tissues. CLL with high-level expression of ROR1 also have high-level expression of Bcl2, but low-to-negligible miR-15/16 Moreover, CLL cases with high-level ROR1 have deletion(s) at the chromosomal location of the genes encoding miR-15/16 (13q14) more frequently than cases with low-to-negligible ROR1, implying that deletion of miR-15/16 may promote overexpression of ROR1, in addition to BCL2 ROR1 is a receptor for Wnt5a, which can promote leukemia-cell proliferation and survival, and can be targeted by cirmtuzumab, a humanized anti-ROR1 mAb. We find that this mAb can enhance the in vitro cytotoxic activity of venetoclcax for CLL cells with high-level expression of ROR1, indicating that combining these agents, which target ROR1 and Bcl2, may have additive, if not synergistic, activity in patients with this disease.

Published
2017

22. Analysis of Discomfort During a 4-Hour Shift in Quay Crane Operators Objectively Assessed Through In-Chair Movements

Author

Leban, Bruno, Arippa, Federico, Fancello, Gianfranco, Fadda, Paolo, Pau, Massimiliano, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bagnara, Sebastiano, editor, Tartaglia, Riccardo, editor, Albolino, Sara, editor, Alexander, Thomas, editor, and Fujita, Yushi, editor

Published
2019
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25. MicroRNA Expression Profile in Acute Ischemic Stroke

Author

Mainali, Shraddha, primary, Nepal, Gaurav, additional, Webb, Amy, additional, Fadda, Paolo, additional, Mirebrahimi, Darya, additional, Nana-Sinkam, Patrick, additional, Worrall, Brad, additional, Woo, Daniel, additional, Johnson, Nicholas, additional, and Hamed, Mohammad, additional

Published
2024
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26. Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice.

Author

DiSilvestro, David J, Melgar-Bermudez, Emiliano, Yasmeen, Rumana, Fadda, Paolo, Lee, L James, Kalyanasundaram, Anuradha, Gilor, Chen L, and Ziouzenkova, Ouliana

Subjects
Cells, Cultured, 3T3-L1 Cells, Adipocytes, Animals, Mice, Mice, Obese, Glucose Intolerance, Insulin Resistance, Obesity, Leptin, RNA, Messenger, Blotting, Western, Reverse Transcriptase Polymerase Chain Reaction, Cell Differentiation, Male, Resistin, Adipose Tissue, Brown, Real-Time Polymerase Chain Reaction, Adipose Tissue, Brown, Blotting, Western, Cells, Cultured, Obese, RNA, Messenger, General Science & Technology
Abstract

The neuroendocrine effects of leptin on metabolism hold promise to be translated into a complementary therapy to traditional insulin therapy for diabetes and obesity. However, injections of leptin can provoke inflammation. We tested the effects of leptin, produced in the physiological adipocyte location, on metabolism in mouse models of genetic and dietary obesity. We generated 3T3-L1 adipocytes constitutively secreting leptin and encapsulated them in a poly-L-lysine membrane, which protects the cells from immune rejection. Ob/ob mice (OB) were injected with capsules containing no cells (empty, OB[Emp]), adipocytes (OB[3T3]), or adipocytes overexpressing leptin (OB[Lep]) into both visceral fat depots. Leptin was found in the plasma of OB[Lep], but not OB[Emp] and OB[3T3] mice at the end of treatment (72 days). The OB[Lep] and OB[3T3] mice have transiently suppressed appetite and weight loss compared to OB[Emp]. Only OB[Lep] mice have greater brown fat mass, metabolic rate, and reduced resistin plasma levels compared to OB[Emp]. Glucose tolerance was markedly better in OB[Lep] vs. OB[Emp] and OB[3T3] mice as well as in wild type mice with high-fat diet-induced obesity and insulin resistance treated with encapsulated leptin-producing adipocytes. Our proof-of-principle study provides evidence of long-term improvement of glucose tolerance with encapsulated adipocytes producing leptin.

Published
2016

27. Association ofESR1germline variants withTP53somatic variants in breast tumors in a genome-wide study

Author

Tjader, Nijole P, primary, Beer, Abigail J, additional, Ramroop, Johnny, additional, Tai, Mei-Chee, additional, Ping, Jie, additional, Gandhi, Tanish, additional, Dauch, Cara, additional, Neuhausen, Susan L, additional, Ziv, Elad, additional, Sotelo, Nereida, additional, Ghanekar, Shreya, additional, Meadows, Owen, additional, Paredes, Monica, additional, Gillespie, Jessica, additional, Aeilts, Amber, additional, Hampel, Heather, additional, Zheng, Wei, additional, Jia, Guochong, additional, Hu, Qiang, additional, Wei, Lei, additional, Liu, Song, additional, Ambrosone, Christine B., additional, Palmer, Julie R., additional, Carpten, John D., additional, Yao, Song, additional, Stevens, Patrick, additional, Ho, Weang-Kee, additional, Pan, Jia Wern, additional, Fadda, Paolo, additional, Huo, Dezheng, additional, Teo, Soo-Hwang, additional, McElroy, Joesph Paul, additional, and Toland, Amanda Ewart, additional

Published
2023
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29. TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia

Author

Balatti, Veronica, Rizzotto, Lara, Miller, Cecelia, Palamarchuk, Alexey, Fadda, Paolo, Pandolfo, Rosantony, Rassenti, Laura Z, Hertlein, Erin, Ruppert, Amy S, Lozanski, Arletta, Lozanski, Gerard, Kipps, Thomas J, Byrd, John C, Croce, Carlo M, and Pekarsky, Yuri

Subjects
Rare Diseases, Cancer, Genetics, Biotechnology, Lymphoma, Hematology, 2.1 Biological and endogenous factors, Aetiology, Gene Deletion, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, MicroRNAs, Proto-Oncogene Proteins, Tumor Suppressor Protein p53, miR-3676, CLL, 17p deletions
Abstract

B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia and dysregulation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease based on transgenic mouse studies. To determine a role of microRNAs on the pathogenesis of the aggressive form of CLL we studied regulation of TCL1 expression in CLL by microRNAs. We identified miR-3676 as a regulator of TCL1 expression. We demonstrated that miR-3676 targets three consecutive 28-bp repeats within 3'UTR of TCL1 and showed that miR-3676 is a powerful inhibitor of TCL1. We further showed that miR-3676 expression is significantly down-regulated in four groups of CLL carrying the 11q deletions, 13q deletions, 17p deletions, or a normal karyotype compared with normal CD19(+) cord blood and peripheral blood B cells. In addition, the sequencing of 539 CLL samples revealed five germ-line mutations in six samples (1%) in miR-3676. Two of these mutations were loss-of-function mutations. Because miR-3676 is located at 17p13, only 500-kb centromeric of tumor protein p53 (Tp53), and is codeleted with Tp53, we propose that loss of miR-3676 causes high levels of TCL1 expression contributing to CLL progression.

Published
2015

32. Deregulated miRNA Expression in Triple-Negative Breast Cancer of Ancestral Genomic-Characterized Latina Patients

Author

Almohaywi, Maram, primary, Sugita, Bruna M., additional, Centa, Ariana, additional, Fonseca, Aline S., additional, Antunes, Valquiria C., additional, Fadda, Paolo, additional, Mannion, Ciaran M., additional, Abijo, Tomilowo, additional, Goldberg, Stuart L., additional, Campbell, Michael C., additional, Copeland, Robert L., additional, Kanaan, Yasmine, additional, and Cavalli, Luciane R., additional

Published
2023
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45. Expression of microRNAs and their target genes in melanomas originating from gynecologic sites

Author

DiVincenzo, Mallory J., primary, Angell, Colin D., additional, Suarez-Kelly, Lorena P., additional, Ren, Casey, additional, Barricklow, Zoe, additional, Moufawad, Maribelle, additional, Fadda, Paolo, additional, Yu, Lianbo, additional, Backes, Floor J., additional, Ring, Kari, additional, Mills, Anne, additional, Slingluff, Craig, additional, Chung, Catherine, additional, Gru, Alejandro A., additional, and Carson, William E., additional

Published
2023
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