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Craniofacial phenotyping is critical for both syndrome delineation and diagnosis because craniofacial abnormalities occur in 30% of characterized genetic syndromes. Clinical reports, textbooks, and available software tools typically provide two-dimensional, static images and illustrations of the characteristic phenotypes of genetic syndromes. In this work, we provide an interactive web application that provides three-dimensional, dynamic visualizations for the characteristic craniofacial effects of 95 syndromes. Users can visualize syndrome facial appearance estimates quantified from data and easily compare craniofacial phenotypes of different syndromes. Our application also provides a map of morphological similarity between a target syndrome and other syndromes. Finally, users can upload 3D facial scans of individuals and compare them to our syndrome atlas estimates. In summary, we provide an interactive reference for the craniofacial phenotypes of syndromes that allows for precise, individual-specific comparisons of dysmorphology.

In view of the characteristics of low permeability, strong heterogeneity, small effective sand scale and poor connectivity of tight gas reservoir, well pattern infilling optimization is the main method to improve gas recovery. Taking Sulige gas field as an example, based on the study of sedimentary facies, effective sand-body distribution, combined with production performance and engineering parameters, the well control drainage was obtained. Meanwhile, the interwell connectivity and interference probability was qualitatively analyzed by interference well test, and the critical well spacing density was determined. In order to quantitatively reveal the gas grabbing degree at different well spacing density and determine whether the final cumulative gas production of gas wells with interference is economical and feasible, the evaluation index of "gas well production interference ratio (GWPIR)" was defined specifically, and the intersection plot of GWPIR relating to gas reserve abundance and well spacing density was draw. Different from the traditional method of well number interference probability, through the combination of GWPIR plot and economic evaluation, well pattern optimization from both two perspectives of pursuing higher economic benefits and recovery degree can be realized, providing technical support for improving gas recovery and long-term stable production of gas field. [ABSTRACT FROM AUTHOR]

The distributary channels in shallow‐water delta are well‐developed in tight sandstone. There are few studies on the channel type and diagenetic differences among them. To illustrate the relationship between channel types and high‐quality reservoirs, this study summarizes the lithofacies types and sequences in the second member of the Xujiahe Formation. We use core data, outcrops, and modern sediments observation, scanning energy spectrum, and rock thin sections. The lithofacies can be divided into 15 types, and there are four types of vertical lithofacies sequence. Lithofacies sequences are different in lithofacies, channel scale, reservoir porosity and permeability, and so forth. They are formed in various hydrodynamic environments. With the continuous bifurcation of the channels, the width and depth of the channels are decreasing, forming different lithofacies sequences. Four types of distributary channels are classified. The characteristics of these channels are described, and the sedimentary models are established. Distributary channel types are related to the diagenetic process. Channel type I and the bottom of type II develop moderate compaction–dissolution diagenetic facies, the middle and upper parts of type II and type III can develop strong compaction, moderate compaction–dissolution, or strong cementation diagenetic facies, and type IV can develop strong compaction diagenetic facies. High‐quality reservoirs are developed in limitedly distributed in distributary channels of type I and type II, and part of type III. This study provides a useful view for evaluating high‐quality reservoirs based on distributary channel types. [ABSTRACT FROM AUTHOR]