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3. Data segmentation based on the local intrinsic dimension

Author

Allegra, M, Facco, E, Denti, F, Laio, A, Mira, A, Allegra M., Facco E., Denti F., Laio A., Mira A., Allegra, M, Facco, E, Denti, F, Laio, A, Mira, A, Allegra M., Facco E., Denti F., Laio A., and Mira A.

Abstract

One of the founding paradigms of machine learning is that a small number of variables is often sufficient to describe high-dimensional data. The minimum number of variables required is called the intrinsic dimension (ID) of the data. Contrary to common intuition, there are cases where the ID varies within the same data set. This fact has been highlighted in technical discussions, but seldom exploited to analyze large data sets and obtain insight into their structure. Here we develop a robust approach to discriminate regions with different local IDs and segment the points accordingly. Our approach is computationally efficient and can be proficiently used even on large data sets. We find that many real-world data sets contain regions with widely heterogeneous dimensions. These regions host points differing in core properties: folded versus unfolded configurations in a protein molecular dynamics trajectory, active versus non-active regions in brain imaging data, and firms with different financial risk in company balance sheets. A simple topological feature, the local ID, is thus sufficient to achieve an unsupervised segmentation of high-dimensional data, complementary to the one given by clustering algorithms.

Published
2020

11. Hypnosis as sole anesthesia for oral surgery: The egg of Columbus

Author

Facco, E., Bacci, C., and Zanette, G.

Subjects
sedation, Local, dentistry, Analgesia, hypnosis, oral surgery, Anesthetics, Local, Humans, Pain Measurement, Tooth Extraction, Anesthesia, Dental, Hypnosis, Dental, Anesthesia, Anesthetics
Published
2021

14. Data segmentation based on the local intrinsic dimension

Author

Allegra, M., Facco, E., Denti, Francesco, Laio, A., Mira, A., Denti F. (ORCID:0000-0003-2978-4702), Allegra, M., Facco, E., Denti, Francesco, Laio, A., Mira, A., and Denti F. (ORCID:0000-0003-2978-4702)

Abstract

One of the founding paradigms of machine learning is that a small number of variables is often sufficient to describe high-dimensional data. The minimum number of variables required is called the intrinsic dimension (ID) of the data. Contrary to common intuition, there are cases where the ID varies within the same data set. This fact has been highlighted in technical discussions, but seldom exploited to analyze large data sets and obtain insight into their structure. Here we develop a robust approach to discriminate regions with different local IDs and segment the points accordingly. Our approach is computationally efficient and can be proficiently used even on large data sets. We find that many real-world data sets contain regions with widely heterogeneous dimensions. These regions host points differing in core properties: folded versus unfolded configurations in a protein molecular dynamics trajectory, active versus non-active regions in brain imaging data, and firms with different financial risk in company balance sheets. A simple topological feature, the local ID, is thus sufficient to achieve an unsupervised segmentation of high-dimensional data, complementary to the one given by clustering algorithms.

Published
2020

20. [.sup.99m]Tc-HMPAO SPECT in the diagnosis of brain death

Author

Facco, E., Zucchetta, P., Munari, M., Baratto, F., Behr, A.U., Gregianin, M., Gerunda, A., Bui, F., Saladini, M., and Giron, G.

Subjects
Brain death -- Diagnosis, SPECT imaging -- Usage, Health care industry
Abstract

Byline: E. Facco (1), P. Zucchetta (2), M. Munari (1), F. Baratto (1), A. U. Behr (1), M. Gregianin (2), A. Gerunda (1), F. Bui (2), M. Saladini (3), G. Giron (1) Keywords: Key words Brain death; SPECT; Cerebrovascular circulation; Brain injuries; EEG Abstract: Objective: To evaluate the effectiveness of single proton emission tomography (SPECT) with 99m.sup.Tc-HMPAO in the diagnosis of brain death (BD). Design: Prospective study in comatose and brain-dead patients. Setting: Neurologic ICU. Patients and methods: Fifty comatose patients (age range: 10 days--75 years) were submitted to SPECT study. In 21 of them (42 %) reversible factors (e. g., influence of drugs affecting the central nervous system) were present. Thirty-eight patients were clinically brain-dead, while the remaining 12 were tested both in pre-terminal conditions and after the clinical onset of BD. Interventions: Brain SPECT following i. v. injection of 99m.sup.Tc-HMPAO (300--1100 MBq), using a 4-headed gamma-camera (20 min, 360 deg, 88 images). Measurements and results: All patients tested in pre-terminal conditions showed preserved brain perfusion. Two of them had flat EEGs despite the absence of any reversible cause of coma three patients survived, but remained in persistent vegetative states. SPECT confirmed the diagnosis of BD in 45 out of 47 patients (95.7 %), clearly showing the arrest of brain perfusion (picture of 'empty skull') in two clinically brain-dead children (aged 10 days and 12 months, respectively) weak perfusion of the basal ganglia, thalamus and/or brain stem was still present, precluding the diagnosis of BD both of them died a few days later. Conclusions: Our results confirm the reliability of SPECT in the diagnosis of BD. A problem arises about its effectiveness in brain-dead children, but this seems to be a matter of definition of BD and cerebral viability, rather than a limit of SPECT. Author Affiliation: (1) Lab. Neurophysiology -- Neuro ICU, Dept. of Anesthesiology and Intensive Care, University of Padua, via C. Battisti 267, I-35121 Padova, Italy Tel.: +39.49.8 21 30 90, or +39.336.42 06 04 Fax: +39.49.8 75 42 56 email: efacco@uxl.unipd.it, IT (2) Nuclear Medicine Service I, University of Padua, via C. Battisti 267, I-35121 Padova, Italy, IT (3) Dept. of Neurology, University of Padua, via C. Battisti 267, I-35121 Padova, Italy, IT Article note: Received: 6 October 1997 Accepted: 21 July 1998

Published
1998

21. Neurology

Author

Dominguez-Roldan, J. M., Murillo-Cabezas, F., Munoz-Sanchez, A., Maestre, A., Porras, F., Santamaria-Mifsut, J. L., Facco, E., Munari, M., Baratto, F., Behr, A. U., Bruno, R., Giron, G. P., Sonnet, M. L., Perrot, D., Floret, D., Guillaume, C., Bui-Xuan, B., Vedrinne, J. M., Motin, J., Dall’Acqua, G., Cesaro, S., Giacomini, M., Allaouchiche, B., Moulaire, V., Bouffard, Y., Latronico, N., Fenzi, F., Guarneri, B., Tomelleri, G., Tonin, P., Rizzuto, N., Candiani, A., Lacguaniti, L. G., Irone, M., Zamperetti, N., Gulino, A., Pellegrin, C., Dan, M., Sandroni, C., Bareili, A., Piazza, O., Della Corte, F., Kovacs, A., Cucurachi, M., Sab J. M., Sirodot M., Straboni J. P., Dorez D., Dubols J. M., Gaussorgues Ph., Robert D., Delafosse, B., Kopp, N., Faure, J. L., Neidecker, J., Parma, A., Marzorati, S., Rampini, P. M., Egidi, M., Calappi, E., Massci, R., Montolivo, M., Gemma, M., Regi, B., Fiacchino, F., Montero, J. Garnacho, Leyba, C. Ortiz, Osuna, J. Madrazo, Jimenez, J. Jimenez, Noval, R. Leal, Hernandez, P. Chaparro, Gervaix, A., Beghetti, M., Berner, M., Schneider, A., Rilliet, B., Berré, J., De Backer, D., Moraine, J. J., Vincent, J. L., Kahn, R. J., Latour, J., Reig, A., Ribera, D., Alemañ, M. C., Basco, J. L., López, M., Pastor, M., Carrasco, F., Zaplana, J., Ruiz, M. R., Sánchez, M., Boillot, A., Capellier, G., Balvay, P., Cordier, A., Tissot, M., Barale, F., Bricchi, M., and Franceschetti, S.

Published
1992
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27. RENEB accident simulation exercise

Author

Brzozowska, B., Ainsbury, E., Baert, A.E., Beaton-Green, L., Barrios, L., Barquinero, J.F., Bassinet, C., Beinke, C., Benedek, A., Beukes, P., Bortolin, E., Buraczewska, I., Burbidge, C.I., de Amicis, A., de Angelis, C., Della Monaca, S., Depuydt, J., de Sanctis, S., Dobos, K., Domene, M.M., Domínguez, I., Facco, E., Fattibene, P., Frenzel, M., Monteiro Gil, O., Gonon, G., Gregoire, E., Gruel, G., Hadjidekova, V., Hatzi, V.I., Hristova, R., Jaworska, A., Kis, E., Kowalska, M., Kulka, U., Lista, F., Lumniczky, K., Martínez-López, W., Meschini, R., Mörtl, S., Moquet, J., Noditi, M., Oestreicher, U., Orta Vázquez, M.L., Palma, V., Pantelias, G., Montoro Pastor, A., Patrono, C., Piqueret-Stephan, L., Quattrini, M.C., Regalbuto, E., Ricoul, M., Roch-Lefevre, S., Roy, L., Sabatier, L., Sarchiapone, L., Sebastià, N., Sommer, S., Sun, M., Suto, Y., Terzoudi, G., Trompier, F., Vral, A., Wilkins, R., Zafiropoulos, D., Wieser, A., Woda, C., Wojcik, A., Istituto Superiore di Sanita` (ISS), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Bundesamt für Strahlenschutz (BfS), National center for public health [Hungary], Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Hospital Universitario y Politécnico La Fe, Public Health England [London], Universiteit Gent = Ghent University [Belgium] (UGENT), Helmholtz-Zentrum München (HZM), Stockholm University, University of Warsaw (UW), Universitat Autònoma de Barcelona (UAB), Bundeswehr Institute of Radiobiology, Universität Ulm - Ulm University [Ulm, Allemagne], Seventh Framework Programme, Istituto Superiore di Sanità (ISS), Bundesamt für Strahlenschutz - Federal Office for Radiation Protection (BfS), Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe, Universiteit Gent = Ghent University (UGENT), and Helmholtz Zentrum München = German Research Center for Environmental Health

Subjects
RENEB network, Safety Management, [SDV]Life Sciences [q-bio], Radiobiology, Biology and Life Sciences, Disaster Planning, Reneb Network, Accident Simulation, Radiobiological Event, Europe, radiobiological event, Radiation Monitoring, Medicine and Health Sciences, accident simulation, Triage, Radioactive Hazard Release
Abstract

International audience; Purpose: The RENEB accident exercise was carried out in order to train the RENEB participants in coordinating and managing potentially large data sets that would be generated in case of a major radiological event. Materials and methods: Each participant was offered the possibility to activate the network by sending an alerting email about a simulated radiation emergency. The same participant had to collect, compile and report capacity, triage categorization and exposure scenario results obtained from all other participants. The exercise was performed over 27 weeks and involved the network consisting of 28 institutes: 21 RENEB members, four candidates and three non-RENEB partners. Results: The duration of a single exercise never exceeded 10 days, while the response from the assisting laboratories never came later than within half a day. During each week of the exercise, around 4500 samples were reported by all service laboratories (SL) to be examined and 54 scenarios were coherently estimated by all laboratories (the standard deviation from the mean of all SL answers for a given scenario category and a set of data was not larger than 3 patient codes). Conclusions: Each participant received training in both the role of a reference laboratory (activating the network) and of a service laboratory (responding to an activation request). The procedures in the case of radiological event were successfully established and tested. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Published
2017

30. Antioxidant capacity and composition of pitanga seeds Capacidade antioxidante e composição de sementes de pitanga

Author

Bagetti, M., Facco, E. M. P., Rodrigues, D. B., Márcia Vizzotto, and Emanuelli, T.

Subjects
lcsh:Agriculture, FRAP, lcsh:S, antioxidant capacity, Eugenia uniflora L, lcsh:Agriculture (General), capacidade antioxidante, lcsh:S1-972, DPPH
Abstract

Food industry generates a significant amount of seed wastes from the juice production, frozen pulps and jams. Considering that the characterization of wastes is the first step to determine their potential use, the aim of the present study was to determine the composition and the antioxidant capacity of seeds from pitanga fruits with different flesh colors (purple, red and orange). Chemical composition results revealed that pitanga seeds are a good source of insoluble dietary fiber, with low protein and fat levels, and no relevant differences were found among pitanga seeds from different flesh colors. Pitanga seed extracts had powerful antioxidant capacity that was partially correlated to their high phenolic content and showed some variation according to the pitanga flesh colors. Accordingly, it's suggested that this low value waste of pitanga processing, could be used as a source of natural antioxidants and dietary fiber, for animal and/or human nutrition.A indústria de alimentos gera quantidades significativas de resíduos de sementes a partir da produção de sucos, polpas congeladas e geleias de frutas. Considerando que a caracterização dos resíduos é o primeiro passo para determinar o seu uso potencial, o objetivo do presente estudo foi determinar a composição e a capacidade antioxidante de sementes de pitanga com diferentes colorações de polpa (roxa, vermelha e laranja). Os resultados da composição química revelaram que as sementes de pitanga são boas fontes de fibra alimentar insolúvel, com níveis baixos de proteína e gordura, e sem diferenças relevantes entre as sementes de pitangas de diferentes colorações. Os extratos das sementes apresentaram uma excelente capacidade antioxidante, que foi parcialmente correlacionada com o alto teor de fenólicos e apresentou alguma variação de acordo com a coloração da polpa das pitangas. Assim, sugere-se que esse resíduo de baixo valor, resultante do processamento da pitanga, poderia ser utilizado como fonte de antioxidantes naturais e de fibra alimentar, para a nutrição humana e/ou animal.

Published
2009

36. A Synopsis of articles of interest from the last twelve months to inspire further reading.

Author

Facco, E. and Zanette, G.

Subjects
FEAR of dentists, PSYCHOSOMATIC disorders, EMOTIONS, MENTAL health, DENTAL care
Abstract

Dental anxiety (DA) can be considered as a universal phenomenon with a high prevalence worldwide; DA and pain are also the main causes for emergencies in the dental setting, so their prevention is an essential part of patient safety and overall quality of care. DA and its consequences are closely related to the fight-or-flight reaction and it seems reasonable to argue that the odyssey of DA began way back in the distant past, and has since probably evolved in parallel with the development of fight-or-flight reactions, implicit memory and knowledge, and ultimately consciousness. Basic emotions are related to survival functions in an inseparable psychosomatic unity that enable an immediate response to critical situations rather than generating knowledge, which is why many anxious patients are unaware of the cause of their anxiety. [ABSTRACT FROM AUTHOR]

Published
2018
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37. The SIAARTI document in preparation: 'Recommendations on admission and discharge from intensive care units and on limits of treatments in intensive care' [Verso il documento SIAARTI «Raccomandazioni per l'ammissione e la dimissione dalla Terapia Intensiva e per la limitazione dei trattamenti in Terapia Intensiva» Contenuti principali]

Author

Orsi L., Albani A., Barneschi M. G., Pallavicini F. B., Braschi A., Cecioni R., Cornara G., Defanti C. A., Giannini A., Facco E., Fucci S., Giunta F., Giurati G., Iapichino G., Marchesi M., Mazzon D., Mori M., Neri D., Riccio M., Santosuosso A., Scesi M., Turetta F., Zamperetti N., TUFANO, ROSALBA, Orsi, L., Albani, A., Barneschi, M. G., Pallavicini, F. B., Braschi, A., Cecioni, R., Cornara, G., Defanti, C. A., Giannini, A., Facco, E., Fucci, S., Giunta, F., Giurati, G., Iapichino, G., Marchesi, M., Mazzon, D., Mori, M., Neri, D., Riccio, M., Santosuosso, A., Scesi, M., Tufano, Rosalba, Turetta, F., and Zamperetti, N.

Published
2002

38. Caracterização físico-química de variedades de amora-preta da região sul do Brasil

Author

HIRSCH, G. E., FACCO, E. M. P., RODRIGUES, D. B., VIZZOTTO, M., EMANUELLI, T., Gabriela Elisa Hirsch, Universidade Federal de Santa Maria, Elizete Maria Pesamosca Facco, Universidade de Caxias do Sul, Daniele Bobrowski Rodrigues, Universidade Federal de Santa Maria, MARCIA VIZZOTTO, CPACT, and Tatiana Emanuelli, Universidade Federal de Santa Maria.

Subjects
Amora-preta
Published
2012

39. Anestesia odontoiatrica ed emergenze

Author

Arvalli, M. A., Barbieri, A., Betti, D., Bosco, M., Casiglia, E., Dauri, M., Di Bella, O., Dones, F., Facco, E., Favaro, R., Fontana, G., Giacomello, M., Latronico, N., Lucangelo, U., Luzzani, A., Manani, G., Mazzuchin, M., Mulas, M., Santangelo, E., Volta, C. A., Venuti, Francesco Saverio, Zanette, G., and Zanette, L.

Published
2011

40. Recommendations for airway control and difficult airway management in thoracic aneshtesia and lung separation procedures

Author

Merli, G, Guarino, A., Della Rocca, G, Frova, G, Petrini, F, Sorbello, M, Coccia, C, Accorsi, A, Adrario, E, Agro, F, Amicucci, G, Antonelli, M, Azzeri, F, Baroncini, S, Bettelli, G, Biolcati, F, Cafaggi, C, Cattano, D, Chinelli, E, Collavo, T, Corbanese, U, Corso, R, di Filippo, A, di Giacinto, I, Donato, P, Facco, E, Favaro, R, Ferraro, F, Finco, G, Galante, D, Gattinoni, L, Giunta, F, Giurati, G, Giusti, F, Guarino, A, Ian-Nuzzi, E, Ivani, G, Ledda, G, Marchi, A, Mattioli, V, Menarini, M, Miceli, L, Mondello, E, Morossi, M, Oligeri, M, Pala, F, Pesetti, B, Pigna, A, Pittoni, G, Ripamonti, D, Rosa, G, Rosi, R, Salvo, I, Santangelo, E, Sarti, A, Scoponi, M, Serafini, G, Tana, F, Tufano, R, Vesconi, S, Villani, A, and Zauli, M.

Published
2009

42. Recommendations for airway control and difficult airway management in thoracic anesthesia and lung separation procedures

Author

Accorsi, A, Adrario, E, Agrò, F, Amicucci, G, Antonelli, M, Azzeri, F, Baroncini, S, Bettelli, G, Biolcati, F, Cafaggi, C, Cattano, D, Chinelli, E, Collavo, T, Corbanese, U, Corso, Ruggero Massimo, Della Rocca, G, Di Filippo, Alessandro, Di Giacinto, I, Donato, P, Facco, E, Favaro, R, Ferraro, F, Finco, G, Frova, G, Galante, D, Gattinoni, L, Giunta, F, Giurati, G, Giusti, F, Guarino, A, Iannuzzi, E, Ivani, G, Ledda, G, Marchi, A, Mattioli, V, Menarini, M, Merli, G, Miceli, L, Mondello, E, Morossi, M, Oligeri, M, Pala, F, Pesetti, B, Petrini, F, Pigna, A, Pittoni, G, Ripamonti, D, Rosa, G, Rosi, R, Salvo, I, Santangelo, E, Sarti, A, Scoponi, M, Serafini, G, Sorbello, Massimiliano, Tana, F, Tufano, R, Vesconi, S, Villani, A, and Zauli, M.

Subjects
Anesthesia, General, Humans, Lung, Respiration, Artificial, Thoracic Surgical Procedures
Published
2009

43. IL DOLORE OROFACCIALE CRONICO

Author

Facco, E., Gastone Zanette, LORENZO FAVERO, Guarda Nardini, L., stefano sivolella, Christian Bacci, and Manani, G.

Published
2009

44. Recommendations for airway control and difficult airway management

Author

Petrini, F., Accorsi, A., Adrario, E., Agro, F., Amicucci, G., Antonelli, M., Azzeri, F., Baroncini, S., Bettelli, G., Cafaggi, C., Cattano, D., Chinelli, E., Corbanese, U., Corso, R., Della Puppa, A., Di Filippo, A., Facco, E., Favaro, Roberto, Favero, R., Frova, G., Giunta, F., Giurati, G., Giusti, F., Guarino, A., Iannuzzi, E., Ivani, G., Mazzon, D., Menarini, M., Merli, G., Mondello, E., Muttini, S., Nardi, G., Pigna, A., Pittoni, G., Ripamonti, D., Rosa, Giovanni, Rosi, R., Salvo, I., Sarti, A., Serafini, G., Servadio, G., Sgandurra, A., Sorbello, M., Tana, F., Tufano, R., Vesconi, S., Villani, A., Zauli, M., vie Aeree Difficili Gruppo Di Studio Siaarti, Sarnepi Task Force, Irc E., F., Petrini, A., Accorsi, E., Adrario, F., Agrò, G., Amicucci, M., Antonelli, F., Azzeri, S., Baroncini, G., Bettelli, C., Cafaggi, D., Cattano, E., Chinelli, U., Corbanese, R., Corso, A., Della Puppa, A., Di Filippo, E., Facco, R., Favaro, R., Favero, G., Frova, F., Giunta, G., Giurati, F., Giusti, A., Guarino, E., Iannuzzi, G., Ivani, D., Mazzon, M., Menarini, G., Merli, E., Mondello, S., Muttini, G., Nardi, A., Pigna, G., Pittoni, D., Ripamonti, G., Rosa, R., Rosi, I., Salvo, A., Sarti, G., Serafini, G., Servadio, A., Sgandurra, M., Sorbello, F., Tana, Tufano, Rosalba, S., Vesconi, A., Villani, M., Zauli, Gruppo di, Studio, and I. R., C.

Subjects
pediatric patient, vie aeree, Laryngoscopy, Intubation, Intratracheal, Humans, Anesthesia, Inhalation, Intraoperative Complications, Algorithms
Published
2005

46. Recommendations for airway control and difficult airway management. Minerva Anestesiol. 2005 Nov;71(11):617-57

Author

Petrini, F, Accorsi, A, Adrario, E, Agro, F, Amicucci, G, Antonelli, M, Azzeri, F, Baroncini, S, Bettelli, G, Cafaggi, C, Cattano, D, Chinelli, E, Corbanese, U, Corso, R, DELLA PUPPA, A, DI FILIPPO, A, Facco, E, Favaro, Roberto, Favero, R, Frova, G, Giunta, F, Giurati, G, Giusti, F, Guarino, A, Iannuzzi, E, Ivani, G, Mazzon, D, Menarini, M, Merli, G, Mondello, E, Muttini, S, Nardi, G, Pigna, A, Pittoni, G, Ripamonti, D, Rosa, Giovanni, Rosi, R, Salvo, I, Sarti, A, Serafini, G, Servadio, G, Sgandurra, A, Sorbello, M, Tana, F, Tufano, R, Vesconi, S, Villani, A, Zauli, M, GRUPPO DI STUDIO SIAARTI VIE AEREE, Difficili, Sarnepi, IRC E., and Task, Force

Published
2005

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