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3. From shallow to very shallow image of the highly active Kefalonia - Zakynthos fault system.

Author

Loreto, M. F., Nomikou, P., Ferrante, V., Argnani, A., Ferrante, M. G., Accettella, D., Ametller, R., Bubbi, A., Cova, A., Dal Cin, M., Facchin, L., Ferrante, M., Fiorentino, A., Iurcev, M., Lampidou, D., Merino, I., Nikoli, E., Ligi, M., Muccini, F., and Palmiotto, C.

Subjects
GEOLOGIC faults, SEDIMENTS, ROCK deformation, GEOMORPHOLOGY
Published
2023

4. Southern Adriatic Sea as a Potential Area for CO2 Geological Storage

Author

Volpi V., Forlin F., Donda F., Civile D., Facchin L., Sauli S., Merson B., Sinza-Mendieta K., and Shams A.

Subjects
Chemical technology, TP1-1185, Energy industries. Energy policy. Fuel trade, HD9502-9502.5
Abstract

The Southern Adriatic Sea is one of the five prospective areas for CO2 storage being evaluated under the three year (FP7) European SiteChar project dedicated to the characterization of European CO2 storage sites. The potential reservoir for CO2 storage is represented by a carbonate formation, the wackstones and packstones of the Scaglia Formation (Upper Cretaceous-Paleogene). In this paper, we present the geological characterization and the 3D modeling that led to the identification of three sites, named Grazia, Rovesti and Grifone, where the Scaglia Formation, with an average thickness of 50 m, reveals good petrophysical characteristics and is overlain by an up to 1 200 thick caprock. The vicinity of the selected sites to the Enel - Federico II power plant (one of the major Italian CO2 emittor) where a pilot plant for CO2 capture has been already started in April 2010, represents a good opportunity to launch the first Carbon Capture and Storage (CCS) pilot project in Italy and to apply this technology at industrial level, strongly contributing at the same time at reducing the national CO2 emissions.

Published
2015
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8. Tavola 8 Calabria Ionica

Author

Ceramicola, S., Fanucci, F., Corselli, C., Colizza, E., Morelli, D., Cova, A., Savini, A., Praeg, D., Zecchin, M., Caburlotto, A., Candoni, O., Civile, D., Coste, M., Cotterle, D., Critelli, S., Cuppari, A., De Ponte, M., Dominici, R., Forlin, E., Gordini, E., Tessarolo, C., Marchese, F., Muto, F., Palamara, S., Ramella, R., Facchin, L., and Romeo, R.

Subjects
Marine geohazard, seafloor mapping, Magic Project, Ionian Sea, Magic Project, Ionian Sea, Marine geohazard, seafloor mapping
Published
2021

10. Nature and origin of fault-controlled fluid seepage across the Maltese Islands

Author

Spatola D., Micallef A., Italiano F., D’Amico S., Caracausi A., Pascale F., Facchin L., Petronio L., Coren F., Blanos R., Pavan A., Paganini P., Sapiano M., Schembri M., Petti, FM, Carmina, B, Cirrincione, R, Monaco, M, and Spatola D.*, Micallef A., Italiano F., D’Amico S., Caracausi A., Pascale F., Facchin L., Petronio L., Coren F., Blanos R., Pavan A., Paganini P., Sapiano M., Schembri M.

Subjects
Environmental management, Settore GEO/02 - Geologia Stratigrafica E Sedimentologica, Hydrology -- Malta, Geotechnical engineering -- Malta, Seepage, fault, Hydrogeology -- Malta
Abstract

The Maltese Islands are intersected by two major fault systems associated with two diverse rifting episodes affect the islands. The first and most widespread system is Early Miocene to mid-Pliocene in age, and consists of faults that are orientated ENE-WSW. The most distinct of these faults is the Great Fault (known also as the Victoria Lines Fault). The younger system of faults (Late Miocene-Early Pliocene) is still active and consists of faults striking NW to SE that often cross-cut the first generation of faults. The most extensive of these faults is the Maghlaq Fault, located along the southern coastline of the Maltese Islands., peer-reviewed

Published
2018

11. Geophysical and geochemical analysis of shallow gas and an associated pockmark field in Bantry Bay, Co. Cork, Ireland

Author

Jordan, S.F., O'Reilly, S.S., Praeg, D., Dove, D., Facchin, L., Romeo, R., Szpak, M., Monteys, X., Murphy, B.T., Scott, G., McCarron, S.S., Kelleher, B.P., Jordan, S.F., O'Reilly, S.S., Praeg, D., Dove, D., Facchin, L., Romeo, R., Szpak, M., Monteys, X., Murphy, B.T., Scott, G., McCarron, S.S., and Kelleher, B.P.

Abstract

An integrated geophysical, geological, and geochemical investigation of seabed fluid venting was carried out in upper Bantry Bay, a large marine inlet on the southwest coast of Ireland. The results provide evidence of the seafloor venting of gas rich fluids, resulting in the formation of a pockmark field identified here for the first time. The pockmarks occur in an area where sub-bottom profiles provide evidence of chimney-like features interpreted to record upward gas migration through Quaternary sediments to the seafloor. Three vibrocores up to 6 m long were acquired in water depths of 24–34 m, two from the pockmark field and one from outside. Methane of predominantly biogenic origin was quantified in all three cores by headspace analysis of sediment sub-samples. Well-defined sulfate methane transition zones (SMTZs) were observed in two of the cores, the shallowest (1.25 m below sea floor (mbsf)) inside the pockmark field and the other (3.75 mbsf) outside. It is likely that an SMTZ occurs at the location of the third core, also within the pockmark field, although deeper than the samples obtained during this study. Gas migration towards the seafloor is suggested to involve both diffuse pore fluid migration across wide areas and focused flow through the pockmarks, together driven by methanogenesis of pre-glacial lacustrine sediments preserved in a bedrock basin, and possible gas release from the Owenberg River Fault. Analysis of phospholipid fatty acids (PLFAs) and archaeal isoprenoid hydrocarbons was used to investigate the microbial ecology of these sediments. Anaerobic oxidation of methane (AOM) may play a role in controlling release of CH4 to the water column and atmosphere in this shallow gas setting, potentially mediated by syntrophic sulfate reducing bacteria (SRB) and anaerobic methanotrophic archaea (ANME).

Published
2019

19. Studio morfostrutturale dell’offshore del Salento dall’analisi di dati geofisici recentemente acquisiti

Author

Volpi, V., Zgur, F., Facchin, L., Donda, F., Civile, D., Morelli, Danilo, Cuppari, A., ISPRA, S. D'Angelo, A. Fiorentino, V., Volpi, F., Zgur, L., Facchin, F., Donda, D., Civile, Morelli, Danilo, and A., Cuppari

Subjects
Morfo-tettonica, Avanfossa Apula, Golfo di Taranto
Abstract

Il contesto geodinamico che caratterizza lo Ionio settentrionale è estremamente complesso caratterizzato dall'interazione di diversi elementi tettonici che da NO- a SE sono: il Prisma di accrezione dell'Arco Calabro s.s. e l'avampaese costituito dalla piattaforma Apula. L'analisi integrata di dati morfobatimetrici e profili sismici multicanale recentemente acquisiti dalla N/R OGS Explora in varie campagne condotte tra il 2003 e il 2010, ha fornito nuove informazioni riguardo i processi strutturali che hanno coinvolto il margine dal Mesozoico al Presente

Published
2013

20. In search of new imaging for historical earthquakes: a new geophysical survey offshore western Calabria (southern Tyrrhenian Sea, Italy)

Author

Loreto, M. F., Zgur, F., Facchin, L., Fracassi, U., Pettenati, F., Tomini, I., Burca, M., Diviacco, P., Sauli, C., Cossarini, G., De Vittor, C., and Sandron, D.

Subjects
1905 earthquake, active tectonics, mud volcanoes, Gulf of Sant'Eufemia
Abstract

During the summer of 2010 we carried out a survey to acquire a multidisciplinary dataset within the Gulf of Sant'Eufemia (south-eastern Tyrrhenian sea, Italy), with the aim of studying the active tectonics affecting the region, including that potentially responsible for key, elusive earthquakes such as the to-date unexplained September 8, 1905 (M-W 7-7.5) earthquake. The data here analyzed highlight the presence of several tectonic and morphologic features characterizing the investigated area. We have recognized the Angitola Channel, a deep and wide canyon showing a straight trend in its coastward segment, and a meandering trend in the seaward segment. Based on morpho-structural elements, we maintain that the Angitola Channel could be tectonically controlled. Moreover, several gravitational instabilities as slumps and slides affect the flanks of the morpho-structural high, detected offshore Capo Vaticano. Very high resolution seismic data have unveiled the presence of numerous fluid escape features and several mud volcanoes straddling the sector from the coastline to seawards.

Published
2012
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22. The stucco technique of the Magistri Comacini: the case study of St. Maria dei Ghirli in Campione d’Italia (Como, Italy)

Author

Rampazzi, Laura, RIZZO, B., Colombo, C., Conti, C., REALINI, M., BARTOLUCCI, U., Colombini, M., SPIRITI, A., FACCHIN, L., Dipartimento di Scienze Chimiche ed Ambientali, Universitá degli Studi dell’Insubria, Istituto per la Conservazione e la Valorizzazione dei Beni Culturali, Consiglio Nazionale delle Ricerche [Milano] (CNR), Dipartimento di Chimica e Chimica Industriale, University of Pisa - Università di Pisa, Dipartimento di Informatica e Comunicazione, Dipartimento di Arte, Storia e Società, and University of Verona (UNIVR)

Subjects
stuccoes, analyses, spectrometric, artistic technique, [SHS.ART]Humanities and Social Sciences/Art and art history, analisi diagnostica sulla scultura in stucco, scultura in stucco sec. XVII, Baroque, Campione d'Italia, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, laser ablation, Magistri Comacini, microscopic analyses
Abstract

International audience; This article is aimed to define the artistic technique performed by the outstanding artist Isidoro Bianchi for the Baroque stucco decorations in the church of Santa Maria dei Ghirli (Campione d'Italia, Italy). Samples of stucco were examined by means of optical microscopy, scanning electron microscopy with microprobe, X-ray powder diffraction, Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry and laser ablation mass spectrometry equipped with plasma source spectrometry. On the basis of the results obtained art historians made new hypotheses on the biography of the artist and on the historical location of his birthplace.

Published
2012

25. Southern Adriatic Sea as a Potential Area for CO2Geological Storage

Author

Volpi, V., Forlin, F., Donda, F., Civile, D., Facchin, L., Sauli, S., Merson, B., Sinza-Mendieta, K., Shams, A., Volpi, V., Forlin, F., Donda, F., Civile, D., Facchin, L., Sauli, S., Merson, B., Sinza-Mendieta, K., and Shams, A.

Abstract

The Southern Adriatic Sea is one of the five prospective areas for CO2storage being evaluated under the three year (FP7) European SiteChar project dedicated to the characterization of European CO2storage sites. The potential reservoir for CO2storage is represented by a carbonate formation, the wackstones and packstones of the Scaglia Formation (Upper Cretaceous-Paleogene). In this paper, we present the geological characterization and the 3D modeling that led to the identification of three sites, named Grazia, Rovesti and Grifone, where the Scaglia Formation, with an average thickness of 50 m, reveals good petrophysical characteristics and is overlain by an up to 1 200 thick caprock. The vicinity of the selected sites to the Enel- Federico II power plant (one of the major Italian CO2emittor) where a pilot plant for CO2capture has been already started in April 2010, represents a good opportunity to launch the first Carbon Capture and Storage (CCS) pilot project in Italy and to apply this technology at industrial level, strongly contributing at the same time at reducing the national CO2emissions.

Published
2015
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26. PREAMI: Perindopril and remodelling in elderly with acute myocardial infarction: Study rationale and design

Author

Battaglia, A., Ferraro, L., Lo Monaco, M., Palumbo, A., Mariani, M., Biadi, O., Boccalatte, A., Polimeno, S., Rosa, V., Liguori, L., Cuomo, S., Boccanelli, A., Morosetti, P., D Angelo, G., Bottiglieri, P., Brunelli, C., Spallarossa, P., Rolandi, A., Rossettini, Pf, Campa, P., Francesco BARILLA', Biase, L., Biscosi, C., Zampino, D., Capponi, E., Buccolieri, M., Gattobigio, R., Capucci, A., Passerini, F., Piepoli, M., Castello, A., Chiariello, M., Betocchi, S., Ciampi, Q., Losi, M., Corsini, G., Melorio, S., Dalle Mule, J., Mazzella, M., Cristinziani, Gr, Mario, L., Luca, I., Fusco, F., Del Salvatore, B., Sorino, M., Delise, P., Mozzato, Mg, Bilardo, G., Coro, L., Fantinel, M., Zasso, A., Fedele, F., Di Donato, D., Romano, S., Pascale, F., Giasi, M., Ciarcia, L., Lizzardo, A., Mastursi, M., Giordano, A., Benigno, M., Zanelli, E., Campana, M., Giovannini, E., Lacche, A., Pulignano, G., Giuffrida, G., Montana, G., Licciardello, G., L Abbate, A., Carpeggiani, C., Morales, A., Leghissa, R., Mandorla, S., Del Pinto, M., Borgioni, C., Mininni, N., Petrillo, Me, Moretti, G., Bonaglia, M., Zoni, A., Piscicelli, C., Orlandi, M., Panciroli, C., Oddone, A., Caizzi, V., Tartarini, G., Lattanzi, F., Reisenhofer, B., Pascotto, P., Zanocco, A., Dabizzi, Rp, Bini, L., Mondanelli, D., Frascarelli, F., Pitscheider, W., Erlicher, A., Rauhe, W., Bonsante, E., Polimeni, M., Catananti, F., Guerrisi, G., Magnani, B., Rapezzi, C., Ferlito, M., Amati, S., Di Leo, L., Manzo, M., Baldi, C., Cristofaro, M., Citro, R., Raviele, A., Turiano, G., Zuin, G., Rengo, F., Furgi, G., Papa, A., Rotiroti, D., Rosato, G., Siano, F., Pagliuca, MR, Rovelli, G., Heyman, J., Locati, I., Sanguinetti, M., Tomassini, F., Mantovani, R., Sanna, A., Marras, L., Crabu, E., Locci, G., Moio, N., Scilla, C., Tavazzi, L., Magrini, G., Bersano, C., Laudisa, Ml, Trimarco, B., Argenziano, L., Silvestri, S., Valagussa, F., Ciro, E., Cantu, E., Trocino, G., Rossillo, A., Valagussa, L., Finocchi, G., Benvenuto, Gm, Bonanno, C., Ometto, R., Risica, G., Gualandi, G., Facchin, L., Tenderini, P., Nicolosi, Gl, Burelli, C., Macor, F., Bellone, E., Laiso, D., Carvalho, P., Peila, C., Fagiano, A., Gardiol, S., Ganci, B., Presutto, P., Fontanelli, A., Morgera, T., Scarpino, L., Barbuzzi, S., Capogrosso, V., Terrosu, Pf, Contini, Gm, Sabino, G., Pes, R., Uneddu, F., Mecca, D., Tommaso, I., Rusconi, C., Brunazzi, Mc, Codeluppi, P., Pasqualini, M., Gorni, R., Negrelli, M., Paparoni, S., Core, A., Pecce, P., Petrella, L., Zennaro, Rg, Garuti, W., Alfano, G., Bacca, F., Petrucci, G., Paci, Am, Bigalli, G., Mangiameli, S., Gulizia, M., Cardillo, R., Ferrari, G., Tettamanti, F., Butti, E., Picchione, N., Sulla, A., Stroder, P., Perna, Gp, Ricci, S., Generali, Ca, Adornato, E., Ghisio, A., Tidu, M., Ferrari, R., Mele, D., Cicchitelli, G., Merli, E., Russa, O., Azcarate, Jma, Gonzales, Pz, Vilchez, F., Alonso, Lfi, Montero, Jmm, Zarzosa, Cd, Martin, Es, Ros, Jo, Martinez, Mh, Palau, Vm, Carranza, Mst, Mayor, Djlb, Cocina, Eg, Valderrama, Jc, Jimenez, Rp, Pardo, Jam, Cortada, Jb, Lorente, Lj, Guerrero, Jjg, Martinez, A., Coronado, Jlb, Casado, Rs, Cendon, Aa, Cokkinos, D., Maounis, T., Karatasakis, G., Kremastinos, D., Iliodromitis, S., Karatzas, D., Georgiadis, M., Paraskevaidis, I., Toutouzas, P., Antoniadis, P., Angeli, C., Vadas, P., Kaleboubas, M., Stamatelopoulos, S., Nanas, I., Kanakakis, A., Dalianis, A., Zacharoulis, A., Fotiadis, I., Pyrgakis, V., Liata, O., Mazen, B., Kardaras, F., Kardara, D., Krokos, V., Sioras, H., Fousas, S., Stefanidis, A., Papadopoulos, G., Papadopoulos, C., Papagiannis, I., Karidas, I., Zobolos, S., Preami, Investigators, A., Battaglia, L., Ferraro, M. L., Monaco, A., Palumbo, M., Mariani, O., Biadi, A., Boccalatte, S., Polimeno, V. D., Rosa, L., Liguori, S., Cuomo, A., Boccanelli, P., Morosetti, G., D'Angelo, P., Bottiglieri, C., Brunelli, P., Spallarossa, A., Rolandi, P. F., Rossettini, P., Campa, F., Barilla, L. D., Biase, C., Biscosi, D., Zampino, E., Capponi, M., Buccolieri, R., Gattobigio, A., Capucci, F., Passerini, M., Piepoli, A., Castello, M., Chiariello, Betocchi, Sandro, Q., Ciampi, Losi, MARIA ANGELA, G., Corsini, S., Melorio, J. D., Mule, M., Mazzella, G. R., Cristinziani, L., Mario, I. D., Luca, F., Fusco, B. D., Salvatore, M., Sorino, P., Delise, M. G., Mozzato, G., Bilardo, L., Coro', M., Fantinel, A., Zasso, F., Fedele, D. D., Donato, S., Romano, F. D., Pascale, M., Giasi, L., Ciarcia, A., Lizzardo, M., Mastursi, A., Giordano, M., Benigno, E., Zanelli, M., Campana, E., Giovannini, A., Lacche, G., Pulignano, G., Giuffrida, G., Montana, G., Licciardello, A., L'Abbate, C., Carpeggiani, A., Morale, R., Leghissa, S., Mandorla, M. D., Pinto, C., Borgioni, N., Mininni, M. E., Petrillo, G., Moretti, M., Bonaglia, A., Zoni, C., Piscicelli, M., Orlandi, C., Panciroli, A., Oddone, V., Caizzi, G., Tartarini, F., Lattanzi, B., Reisenhofer, P., Pascotto, A., Zanocco, R. P., Dabizzi, L., Bini, D., Mondanelli, F., Frascarelli, W., Pitscheider, A., Erlicher, W., Rauhe, E., Bonsante, M., Polimeni, F., Catananti, G., Guerrisi, B., Magnani, C., Rapezzi, M., Ferlito, S., Amati, L. D., Leo, M., Manzo, C., Baldi, M. D., Cristofaro, R., Citro, A., Raviele, G., Turiano, G., Zuin, F., Rengo, G., Furgi, A., Papa, D., Rotiroti, G., Rosato, F., Siano, M. R., Pagliuca, G., Rovelli, J., Heyman, I., Locati, M., Sanguinetti, F., Tomassini, R., Mantovani, A., Sanna, L., Marra, E., Crabu, G., Locci, N., Moio, C., Scilla, L., Tavazzi, G., Magrini, C., Bersano, M. L., Laudisa, Trimarco, Bruno, L., Argenziano, S., Silvestri, F., Valagussa, E., Ciro, E., Cantu, G., Trocino, A., Rossillo, L., Valagussa, G., Finocchi, G. M., Benvenuto, C., Bonanno, R., Ometto, G., Risica, G., Gualandi, L., Facchin, P., Tenderini, G. L., Nicolosi, C., Burelli, F., Macor, E., Bellone, D., Laiso, P., Carvalho, C., Peila, A., Fagiano, S., Gardiol, B., Ganci, P., Presutto, A., Fontanelli, T., Morgera, L., Scarpino, S., Barbuzzi, V., Capogrosso, P. F., Terrosu, G. M., Contini, G., Sabino, R., Pe, F., Uneddu, D., Mecca, I. D., Tommaso, C., Rusconi, M. C., Brunazzi, P., Codeluppi, M., Pasqualini, R., Gorni, M., Negrelli, S., Paparoni, A., Core, P., Pecce, L., Petrella, R. G., Zennaro, W., Garuti, G., Alfano, F., Bacca, G., Petrucci, A. M., Paci, G., Bigalli, S., Mangiameli, M., Gulizia, R., Cardillo, G., Ferrari, F., Tettamanti, E., Butti, N., Picchione, A., Sulla, P., Stroder, G. P., Perna, S., Ricci, C. A., Generali, E., Adornato, A., Ghisio, M., Tidu, R., Ferrari, D., Mele, G., Cicchitelli, E., Merli, O., Russa, J. M., A., P. Z., Gonzale, F., Vilchez, L. F. I., J. M. M., C. D., Zarzosa, E. S., Martin, J. O., De, M. H., Martinez, V. M., Palau, M. S. T., D. J. L., E. G., Cocina, J. C., Valderrama, R. P., Jimenez, J. A., M., J. B., Cortada, L. J., Lorente, J. J., G., A., Martinez, J. L., B., R. S., Casado, A. A., Cendon, D., Cokkino, T., Maouni, G., Karatasaki, D., Kremastino, S., Iliodromiti, D., Karatza, M., Georgiadi, I., Paraskevaidi, P., Toutouza, P., Antoniadi, C., Angeli, P., Vada, M., Kalebouba, S., Stamatelopoulo, I., Nana, A., Kanakaki, A., Daliani, A., Zacharouli, I., Fotiadi, V., Pyrgaki, O., Liata, B., Mazen, F., Kardara, D., Kardara, V., Kroko, H., Siora, S., Fousa, A., Stefanidi, G., Papadopoulo, C., Papadopoulo, I., Papagianni, I., Karida, and S., Zobolos

Subjects
Male, Ventricular Remodeling, Myocardial Infarction, Angiotensin-Converting Enzyme Inhibitors, Electrocardiography, ace inhibitors, elderly, heart rate variability, left ventricular remodeling, myocardial infarction, perindopril, Double-Blind Method, Echocardiography, Research Design, Perindopril, Electrocardiography, Ambulatory, Humans, Female, Aged
Abstract

Angiotensin-converting enzyme (ACE) inhibitors reduce mortality, the development of remodeling, left ventricular (LV) dysfunction, and ischemic events, both when administered alone as long-term treatment in patients with impaired LV function and/or heart failure (HF) and as short-term treatment, early after acute myocardial infarction (AMI) and/or HF. The few data available on the use of ACE inhibitors in the elderly after AMI are conflicting. Nothing is known about the effects of ACE inhibitors in elderly postinfarction patients with preserved LV function: these patients have a remarkable medium- to long-term mortality and HF incidence after infarction. The aim of this study is to evaluate, in patients with AMI agedor =65 years, the effects of Perindopril on the combined outcome of death, hospitalization for HF, and heart remodeling, considered to be aor =8% increase in LV end-diastolic volume (LVEDV). Secondary objectives include the same factors listed in the primary end points but considered separately. In addition, safety of the drug, ventricular remodeling, and adaptation are being evaluated. A total of 1100 patients with AMI (first episode or reinfarction), agedor =65 years, and preserved or only moderately depressed LV (LV ejection fractionor =40%), are to be enrolled and randomly assigned to treatment (8 mg for 12 months of Perindopril or placebo, in double-blind conditions). Clinical assessment is performed at fixed times, and periodic evaluations of (1) ventricular shape, dimensions, and function by quantitative 2-D echocardiography, and (2) heart rate variability and arrhythmias by ambulatory electrocardiographic monitoring are anticipated. The results and conclusions will be available by 2002 year.

Published
2000

27. Isolation and genetic characterization of mother-of-snow-white, a maternal effect allele affecting laterality and lateralized behaviors in zebrafish

Author

Domenichini, Alice, Dadda, M., Facchin, L., Bisazza, A., Argenton, F., Domenichini, Alice, Dadda, M., Facchin, L., Bisazza, A., and Argenton, F.

Abstract

In the present work we report evidence compatible with a maternal effect allele affecting left-right development and functional lateralization in vertebrates. Our study demonstrates that the increased frequency of reversed brain asymmetries in a zebrafish line isolated through a behavioral assay is due to selection of mother-of-snow-white (msw), a maternal effect allele involved in early stages of left-right development in zebrafish. msw homozygous females could be identified by screening of their progeny for the position of the parapineal organ because in about 50% of their offspring we found an altered, either bilateral or right-sided, expression of lefty1 and spaw. Deeper investigations at earlier stages of development revealed that msw is involved in the specification and differentiation of precursors of the Kupffer's vesicle, a structure homologous to the mammalian node. To test the hypothesis that msw, by controlling Kupffer's vesicle morphogenesis, controls lateralized behaviors related to diencephalic asymmetries, we analyzed left- and right-parapineal offspring in a "viewing test". As a result, left- and right-parapineal individuals showed opposite and complementary eye preference when scrutinizing a model predator, and a different degree of lateralization when scrutinizing a virtual companion. As maternal effect genes are expected to evolve more rapidly when compared to zygotic ones, our results highlight the driving force of maternal effect alleles in the evolution of vertebrates behaviors. © 2011 Domenichini et al.

Published
2011

34. Skeletal muscle myosin heavy chains in heart failureCorrelation between magnitude of the isozyme shift, exercise capacity, and gas exchange measurements

Author

Vescovo, G., Serafini, F., Dalla Libera, L., Leprotti, C., Facchin, L., Tenderini, P., and Ambrosio, G.B.

Abstract

Background Patients with congestive heart failure (CHF) have a reduced exercise capacity because of the early appearance of fatigue and dyspnea. Qualitative changes in the skeletal muscle composition and metabolism can be responsible for the origin of symptoms Methods We correlated the myosin heavy chain (MHC) composition of the gastrocnemius in 20 patients with different degrees of CHF to NYHA class, diuretic consumption, echocardiographic parameters, and expiratory gases measured during cardiopulmonary exercise testing. MHC composition was determined electrophoretically in skeletal muscle needle microbiopsies and the percent distribution was calculated by densitometry. Maximal cardiopulmonary exercise testing was performed on a treadmill with a modified Naughton protocol. A capnograph was used. Results There was no correlation between ejection fraction, left ventricular end systolic diameter, left ventricular end diastolic diameter, and MHC composition. We found a significant positive correlation between the percentage of MHC1 (slow aerobic isoform) and NYHA class (r^2 = 0.62, p < 0.0001), peak VO"2 (r^2=0.5, p < 0.0004), ventilatory threshold (VT) (r^2 =0.33, p = 0.008) and O"2 pulse (peak VO2/HR) (r^2 = 0.40, p = 0.003). There was a negative correlation between both MHC2a (fast oxidative) and MHC2b (fast glycolytic) with peak VO2 (r^2 = 0.38, p = 0.004 and r^2 = 0.37, p = 0.004, respectively), VT (r^2 = 0.2, p = 0.046 and r^2 = 0.34, p = 0.007, respectively), and O"2 pulse (peak VO"2/HR) (r^2= 0.39, p = 0.003 and r^2= 0.23, p = 0.03). NYHA class was also correlated positively with MHC2a and MHC2b (r^2= 0.46, p = 0.001 and r^2 = 0.41, p< 0.006, respectively) and negatively with the same clinical and functional parameters. Conclusions The correlation between the magnitude of the MHC shift from the slow aerobic to the fast glycolytic and fast oxidative with both functional and objective measurements of exercise capacity (peak VO"2, VT, O"2 pulse) seem to suggest that changes in skeletal muscle composition may play a determining role in exercise tolerance in patients with CHF. (Am Heart J 1998;135:130-7.)

Published
1998
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35. DETERMINANTS OF 6-MONTH MORTALITY IN SURVIVORS OF MYOCARDIAL-INFARCTION AFTER THROMBOLYSIS - RESULTS OF THE GISSI-2 DATA-BASE

Author

VOLPI A, DEVITA C, FRANZOSI MG, GERACI E, MAGGIONI AP, MAURI F, NEGRI E, SANTORO E, TAVAZZI L, TOGNONI G, FERUGLIO GA, LOTTO A, ROVELLI F, SOLINAS P, BRUNO M, CAPPELLO T, COPPINI A, FINCATI F, MANTOVANI G, PANGRAZZI J, POGNA M, TURAZZA FM, ANSELMI M, BARBONAGLIA L, BIGI R, CAVALLI A, FRIGERIO M, GIORDANO A, GUALTIEROTTI C, TORTA D, CAROLA R, GIORDANO F, BARLOTTI R, LOPARCO G, VIGLINO GL, RUGGERI G, GIAMUNDO L, DANESI A, PACIARONI E, GAMBINI C, URBANO G, PURCARO A, FRANCESCONI M, FIGLIOLIA S, CANNONE M, ANTOLINI R, DEVOTI G, CRISTALLINI P, PORCIELLO PI, TEONI P, BURALI A, ZUCCONELLI V, DEMATTEIS C, IERVOGLINI A, SCATASTA M, AMABILI S, CARATTI CA, ZOLA G, FERRAGUTO P, SALICI G, CENTARO A, ROTIROTI D, GENOVESE M, GINEVRINO P, DAMATO N, ALTAMURA CM, COLONNA L, CASTELLANETA G, BOVENZI F, MESSINA D, GALANTINO A, CAMPOREALE N, CUCCHINI F, CAMPOSTELLA L, MALACRIDA R, GENONI M, PELLEGRINI P, BRIDDA A, RIGGI L, ACONE L, MOSCATIELLO G, BRUNO A, INVERNIZZI G, TESPILI M, GUAGLIUMI G, CASARI A, ALBANO T, TOMASSINI B, DIBIASE G, SCARAMUZZINO G, RUGGERO S, BRACCHETTI D, DECASTRO U, FULVI M, BRAITO E, ERLICHER A, OBERLECHNER W, GAGLIARDI RS, BIGHIGNOLI L, BONIZZATO G, RIZZI GM, SCAZZINA L, PERRINI A, STRANEO G, STRANEO U, SCIRE A, VERRIENTI A, GUADALUPI M, STORELLI A, ZUCCA L, DABUSTI M, ALBONICO B, DEPETRA V, TABACCHI GC, SCERVINO R, MEREU D, MAXIA P, BIANCO A, CRABU E, MANGIAMELI S, CENTAMORE G, MALFITANO D, AMICO C, VANCHERI F, SANTOPUOLI G, BALDINI F, PANTALEONI A, CONTESSOTTO F, TERLIZZI R, MERIGHI A, TURCHI E, TEGLIO V, PIGNATTI F, PEZZANA A, GOZZOLINO G, GIGLIO M, PETTINATI G, IEVA M, CIRICUGNO S, CORREALE E, ROMANO S, DIFUCCIA A, CASTELLANO B, NATALE A, CERNETTI C, CELEGON L, CANDELPERGHER G, ARIENZO F, RUSSO F, DEVIVO L, MAY L, ACHILLI G, BLASI A, SORRENTINO F, DATO A, GALLONE P, PALUMBO C, DELLAMONICA R, PAGANO L, ALBERTI A, ORSELLI L, DEPONTI C, PARMIGIANI ML, FERRARI M, ACITO P, BUSI F, DELLAVITTORIA G, BELLET C, BORTOLINI F, ROSSI A, CORONA C, BONDI S, NICCOLINI D, GAMBERI G, ARCURI G, MAIOLINO P, CARROZZA A, DELIO U, CAPRETTI G, MARINONI C, GUASCONI C, SONNINO S, PAGLIEI M, FERRARI G, LOMBARDI R, AGNELLI D, DERINALDIS G, CALCAGNILE A, SIGNORELLI S, BENDINELLI S, LUSETTI L, MOLLAIOLI M, COSMI F, PLASTINA F, VENNERI N, FERACO E, CATELLI P, POLUZZI C, DISTANTE S, BIANCHI C, COPPETTI S, ZAMPAGLIONE G, GATTO C, ZURLO R, USLENGHI E, MARGARIA F, MILANESE U, LOMANTO B, ZIACCHI V, RIVA D, BERTOCCHI P, TIRELLA G, DAULERIO M, SAURO G, BINI A, MAZZONI V, POGGI P, MARESTA A, JACOPI F, PATRONCINI A, PUPITA F, GAGGI S, FRAUSINI G, ANTONIOLI GE, MALACARNE C, CODECA L, CAPPATO R, ANDREOLI L, VARACCA S, BUIO E, FAZZINI PF, PUCCI P, SARRO F, VERGASSOLA R, BARCHIELLI M, DEMATTEIS D, CARRONE M, BRUNOZZI LT, MENICONI L, LIBERATI R, RADOGNA M, TALLONE M, CONTE R, IERI A, ZIPOLI A, SANSONI M, CANZIANI R, GUIDALI P, CRISTALLO E, MARIELLO F, MUZIO L, BENVENUTO MR, BALDINI MR, VECCHIO C, CHIARELLA F, FALCIDIENO M, CECCHI A, GIULIANO G, SEU V, PERUGINI P, TOSELLI A, BASSO F, CORTI E, ROSSI P, DELFINO R, CAPONNETTO S, GNECCO G, GHIGLIOTTI G, PENNESI A, LOMBARDI G, RUGGIERI A, BERTOLO L, SLOMP L, LANZETTA T, MAZZARONE L, CRESTI A, BELLODI G, ZUARINI AM, VENERI L, PARCHI C, GIOVANELLI N, NEGRONI S, DETHOMATIS M, BARGHINI A, MARINO E, RICCI D, LEMME P, DIGIACOMO U, AQUARO G, RONZANI G, OTTELLO B, VONTI V, MORETTI S, PALERMO R, MARSILI P, SIDERI F, RAGAZZINI G, GRAMENZI S, BATTISTINI S, DIODATO T, VALERIO A, TUCCI C, DEPASQUALE B, GELFO PG, BERTULLA A, BOLLINI R, DEMARCHI E, BACCA F, DEGIORGI V, LOCATELLI V, SAVOIA MT, FERRACINI C, BARBARESI F, COTOGNI A, FRANCO G, PASSONI F, DURBANO M, MORETTI G, PEROTTI S, CAPRETTI M, DELBENE P, CASCONE M, BALDINI U, ORLANDI M, ODDONE A, CAIZZI V, MASINI G, LAZZARI M, BALLERINI B, BOZZI L, MOCETTI T, BERTOLINI A, PASOTTI E, SANGUINETTI M, MANTOVANI R, TOGNOLI T, MAGGI A, TUSA M, CAMERONI E, GUERRA GP, REGGIANI A, REDAELLI S, GIUSTI S, TANTALO L, RIZZI A, DIGIOVANNI N, GUZZO V, GABRIELE M, COLOMBO G, ALBERZONI A, SALVIOLI G, GALFETTI F, DOVICO E, BELLUZZI F, GOLA E, CASELLATO F, LECCHI G, CONSOLO F, SACCA CB, CONSOLO A, PICCOLO E, GASPARINI G, MASSA D, BELLI C, DOSSENA MG, CORSINI C, SANNA GP, AZZOLLINI M, TRUAZZA F, NADOR F, DEMARTINI M, BOZZI G, SEREGNI R, PASTINE I, MORPURGO M, CASAZZA F, REGALIA F, MAGGIOLINI S, RIGO R, PANCALDI S, POZZETTI D, PASCOTTO P, FRANCESCHI L, DAINESE F, MELINI L, CAPPELLI C, BERNARDI C, PALMIERI M, BORGIONI L, ZILIO G, SANDRI R, ALITTO F, MASARO G, VALAGUSSA F, SCHIAVINA R, RAVESI D, DANIELLO L, PIANTADOSI FR, BARRA P, ROMEO D, MININNI N, SEVERINO S, MOSTACCI M, CASTELLARI M, BANDA D, ROLANDI R, VILLA WD, CARBONE V, ALLEGRI M, FASCIOLO L, PITTALIS M, MUREDDU V, SORO F, DELEDDA MG, MARRAS E, MARCHI SM, DELUCA C, MANETTA M, VOLTA SD, SPERANDEO V, DONZELLI M, VITRANO MG, PITROLO F, LAMONICA S, BELLANCA G, MESSINA G, MIRTO U, RAINERI A, TRAINA M, DIBENEDETTO A, RIBAUDO E, DIFRANCESCO M, RONCHITELLI R, CARONE M, DIGREGORIO D, DIPAOLO G, PASQUALE M, COREA L, COCCHIERI M, ALUNNI G, PAPI L, CHIRIATTI G, LUPETTI M, GAZZOLA U, ARRUZZOLI S, VILLANI GQ, MELLINI M, MADRUZZA L, PIAZZA R, MICHELI G, FRANCHINI C, BECHI S, MARTINES C, MARCHESE D, GABBIA G, BIGALLI A, CIUTI M, CABANI E, DELCITERNA F, ALFIERI A, CHITI M, LONGHINI J, CODELUPPI P, NEGRELLI M, ZANUTTINI D, NICOLOSI GL, MARTIN G, PETRELLA A, BARDAZZI L, BIANCO GA, CELLAMARE G, GIANNELLI F, LICITRA G, LICITRA R, LETTICA GV, TUMIOTTO G, BELLANTI G, BOSI S, CASALI G, MONDUCCI I, BARONE A, PARENTI F, HEYMAN J, COZZI E, BALDACCI G, BACCOS D, BRIGHI F, DESANCTIS A, BOCK R, ROSSI F, AMATI P, SEMPRINI P, NARDELLI A, BOTTERO G, VARTOLO C, MILAZZOTTO F, DICROCE G, DIMARIO F, ANGRISANI G, AZZOLINI P, NEJA CP, MANZOLI U, ROSSI E, TRANI C, MASINI V, SEBASTIANI F, TOPAI M, BORGIA MC, LUCIANI C, FERRI F, DEPAOLA D, CAPURSO S, TUGNOLI F, VETTA C, ALTIERI T, BORZI M, VISCOMI A, STRIANO U, SALITURI S, ZONZIN P, FIORENCIS R, BADIN A, RAVERA B, BALDI C, SILVESTRI F, ALLEMANO P, REYNAUD S, SANSON A, MILANI L, DESIMONE MV, RUSSO A, VILLELLA A, GRAZINI M, AMIDEI S, ANSELMI L, PICCANICOLINO R, MASCELLI G, TAGLIAMONTE A, MESSINA V, TEDESCHI C, BOSSI M, BISIOLI M, TACCHI G, PAGNI G, VIVALDI F, IBBA GV, SANNIA L, PEDRAZZINI F, BAGNI E, FABII S, ALVINO A, ANTONIELLI E, DORONZO B, MARTINENGO E, BECCHI G, SALMOIRAGHI A, DIGIOVANNA F, CARAMANNO G, CAPORICCI D, BRUN M, GIANI P, FERRARIO G, PECI P, RONCONI G, SKOUSE D, GIUSTINIANI S, CUCCHI GF, TAVASCI E, SILVERII A, MARCELLINI G, SPECA G, STANISCIA D, CIMINO A, SERAFINI N, DEBONIS P, CERRUTI P, BAZZUCCHI M, DALPRA F, SPEROTTO C, MOLE GD, BARBANO G, POMARI F, GASCHINO G, PARIGI A, GANDOLFO N, RONDONI F, BRUSCA A, DILEO M, GOLZIO PG, ABRATE M, SCLAVO MG, ROCCI R, POGGIO G, GIANI S, CUZZUCREA D, BRASCHI GB, SCIACCA R, SAMMARTANO A, FURLANELLO F, BRAITO G, CUZZATO V, TOTIS O, FAURETTO F, LEO F, GALATI A, PALMA P, CAMERINI F, MORGERA T, BARBIERI L, SLAVICK GA, FRESCO C, CUDA A, SARNICOLA P, ARZILLO P, BINAGHI G, MACCHI G, CALVERI G, DIMARCO G, LEVANTESI G, PANERAI C, CATURELLI G, FACCHIN L, SARTORE G, ZARDINI P, MARINO P, CARBONIERI E, NAVA S, MAZZINI C, NAVA R, SERRA N, SASSARA M, NICROSINI F, GANDOLFI P, BERGOGNONI G, BALLESTRA AM, VIOLO C, VOLPI A, DEVITA C, FRANZOSI MG, GERACI E, MAGGIONI AP, MAURI F, NEGRI E, SANTORO E, TAVAZZI L, TOGNONI G, FERUGLIO GA, LOTTO A, ROVELLI F, SOLINAS P, BRUNO M, CAPPELLO T, COPPINI A, FINCATI F, MANTOVANI G, PANGRAZZI J, POGNA M, TURAZZA FM, ANSELMI M, BARBONAGLIA L, BIGI R, CAVALLI A, FRIGERIO M, GIORDANO A, GUALTIEROTTI C, TORTA D, CAROLA R, GIORDANO F, BARLOTTI R, LOPARCO G, VIGLINO GL, RUGGERI G, GIAMUNDO L, DANESI A, PACIARONI E, GAMBINI C, URBANO G, PURCARO A, FRANCESCONI M, FIGLIOLIA S, CANNONE M, ANTOLINI R, DEVOTI G, CRISTALLINI P, PORCIELLO PI, TEONI P, BURALI A, ZUCCONELLI V, DEMATTEIS C, IERVOGLINI A, SCATASTA M, AMABILI S, CARATTI CA, ZOLA G, FERRAGUTO P, SALICI G, CENTARO A, ROTIROTI D, GENOVESE M, GINEVRINO P, DAMATO N, ALTAMURA CM, COLONNA L, CASTELLANETA G, BOVENZI F, MESSINA D, GALANTINO A, CAMPOREALE N, CUCCHINI F, CAMPOSTELLA L, MALACRIDA R, GENONI M, PELLEGRINI P, BRIDDA A, RIGGI L, ACONE L, MOSCATIELLO G, BRUNO A, INVERNIZZI G, TESPILI M, GUAGLIUMI G, CASARI A, ALBANO T, TOMASSINI B, DIBIASE G, SCARAMUZZINO G, RUGGERO S, BRACCHETTI D, DECASTRO U, FULVI M, BRAITO E, ERLICHER A, OBERLECHNER W, GAGLIARDI RS, BIGHIGNOLI L, BONIZZATO G, RIZZI GM, SCAZZINA L, PERRINI A, STRANEO G, STRANEO U, SCIRE A, VERRIENTI A, GUADALUPI M, STORELLI A, ZUCCA L, DABUSTI M, ALBONICO B, DEPETRA V, TABACCHI GC, SCERVINO R, MEREU D, MAXIA P, BIANCO A, CRABU E, MANGIAMELI S, CENTAMORE G, MALFITANO D, AMICO C, VANCHERI F, SANTOPUOLI G, BALDINI F, PANTALEONI A, CONTESSOTTO F, TERLIZZI R, MERIGHI A, TURCHI E, TEGLIO V, PIGNATTI F, PEZZANA A, GOZZOLINO G, GIGLIO M, PETTINATI G, IEVA M, CIRICUGNO S, CORREALE E, ROMANO S, DIFUCCIA A, CASTELLANO B, NATALE A, CERNETTI C, CELEGON L, CANDELPERGHER G, ARIENZO F, RUSSO F, DEVIVO L, MAY L, ACHILLI G, BLASI A, SORRENTINO F, DATO A, GALLONE P, PALUMBO C, DELLAMONICA R, PAGANO L, ALBERTI A, ORSELLI L, DEPONTI C, PARMIGIANI ML, FERRARI M, ACITO P, BUSI F, DELLAVITTORIA G, BELLET C, BORTOLINI F, ROSSI A, CORONA C, BONDI S, NICCOLINI D, GAMBERI G, ARCURI G, MAIOLINO P, CARROZZA A, DELIO U, CAPRETTI G, MARINONI C, GUASCONI C, SONNINO S, PAGLIEI M, FERRARI G, LOMBARDI R, AGNELLI D, DERINALDIS G, CALCAGNILE A, SIGNORELLI S, BENDINELLI S, LUSETTI L, MOLLAIOLI M, COSMI F, PLASTINA F, VENNERI N, FERACO E, CATELLI P, POLUZZI C, DISTANTE S, BIANCHI C, COPPETTI S, ZAMPAGLIONE G, GATTO C, ZURLO R, USLENGHI E, MARGARIA F, MILANESE U, LOMANTO B, ZIACCHI V, RIVA D, BERTOCCHI P, TIRELLA G, DAULERIO M, SAURO G, BINI A, MAZZONI V, POGGI P, MARESTA A, JACOPI F, PATRONCINI A, PUPITA F, GAGGI S, FRAUSINI G, ANTONIOLI GE, MALACARNE C, CODECA L, CAPPATO R, ANDREOLI L, VARACCA S, BUIO E, FAZZINI PF, PUCCI P, SARRO F, VERGASSOLA R, BARCHIELLI M, DEMATTEIS D, CARRONE M, BRUNOZZI LT, MENICONI L, LIBERATI R, RADOGNA M, TALLONE M, CONTE R, IERI A, ZIPOLI A, SANSONI M, CANZIANI R, GUIDALI P, CRISTALLO E, MARIELLO F, MUZIO L, BENVENUTO MR, BALDINI MR, VECCHIO C, CHIARELLA F, FALCIDIENO M, CECCHI A, GIULIANO G, SEU V, PERUGINI P, TOSELLI A, BASSO F, CORTI E, ROSSI P, DELFINO R, CAPONNETTO S, GNECCO G, GHIGLIOTTI G, PENNESI A, LOMBARDI G, RUGGIERI A, BERTOLO L, SLOMP L, LANZETTA T, MAZZARONE L, CRESTI A, BELLODI G, ZUARINI AM, VENERI L, PARCHI C, GIOVANELLI N, NEGRONI S, DETHOMATIS M, BARGHINI A, MARINO E, RICCI D, LEMME P, DIGIACOMO U, AQUARO G, RONZANI G, OTTELLO B, VONTI V, MORETTI S, PALERMO R, MARSILI P, SIDERI F, RAGAZZINI G, GRAMENZI S, BATTISTINI S, DIODATO T, VALERIO A, TUCCI C, DEPASQUALE B, GELFO PG, BERTULLA A, BOLLINI R, DEMARCHI E, BACCA F, DEGIORGI V, LOCATELLI V, SAVOIA MT, FERRACINI C, BARBARESI F, COTOGNI A, FRANCO G, PASSONI F, DURBANO M, MORETTI G, PEROTTI S, CAPRETTI M, DELBENE P, CASCONE M, BALDINI U, ORLANDI M, ODDONE A, CAIZZI V, MASINI G, LAZZARI M, BALLERINI B, BOZZI L, MOCETTI T, BERTOLINI A, PASOTTI E, SANGUINETTI M, MANTOVANI R, TOGNOLI T, MAGGI A, TUSA M, CAMERONI E, GUERRA GP, REGGIANI A, REDAELLI S, GIUSTI S, TANTALO L, RIZZI A, DIGIOVANNI N, GUZZO V, GABRIELE M, COLOMBO G, ALBERZONI A, SALVIOLI G, GALFETTI F, DOVICO E, BELLUZZI F, GOLA E, CASELLATO F, LECCHI G, CONSOLO F, SACCA CB, CONSOLO A, PICCOLO E, GASPARINI G, MASSA D, BELLI C, DOSSENA MG, CORSINI C, SANNA GP, AZZOLLINI M, TRUAZZA F, NADOR F, DEMARTINI M, BOZZI G, SEREGNI R, PASTINE I, MORPURGO M, CASAZZA F, REGALIA F, MAGGIOLINI S, RIGO R, PANCALDI S, POZZETTI D, PASCOTTO P, FRANCESCHI L, DAINESE F, MELINI L, CAPPELLI C, BERNARDI C, PALMIERI M, BORGIONI L, ZILIO G, SANDRI R, ALITTO F, MASARO G, VALAGUSSA F, SCHIAVINA R, RAVESI D, DANIELLO L, PIANTADOSI FR, BARRA P, ROMEO D, MININNI N, SEVERINO S, MOSTACCI M, CASTELLARI M, BANDA D, ROLANDI R, VILLA WD, CARBONE V, ALLEGRI M, FASCIOLO L, PITTALIS M, MUREDDU V, SORO F, DELEDDA MG, MARRAS E, MARCHI SM, DELUCA C, MANETTA M, VOLTA SD, SPERANDEO V, DONZELLI M, VITRANO MG, PITROLO F, LAMONICA S, BELLANCA G, MESSINA G, MIRTO U, RAINERI A, TRAINA M, DIBENEDETTO A, RIBAUDO E, DIFRANCESCO M, RONCHITELLI R, CARONE M, DIGREGORIO D, DIPAOLO G, PASQUALE M, COREA L, COCCHIERI M, ALUNNI G, PAPI L, CHIRIATTI G, LUPETTI M, GAZZOLA U, ARRUZZOLI S, VILLANI GQ, MELLINI M, MADRUZZA L, PIAZZA R, MICHELI G, FRANCHINI C, BECHI S, MARTINES C, MARCHESE D, GABBIA G, BIGALLI A, CIUTI M, CABANI E, DELCITERNA F, ALFIERI A, CHITI M, LONGHINI J, CODELUPPI P, NEGRELLI M, ZANUTTINI D, NICOLOSI GL, MARTIN G, PETRELLA A, BARDAZZI L, BIANCO GA, CELLAMARE G, GIANNELLI F, LICITRA G, LICITRA R, LETTICA GV, TUMIOTTO G, BELLANTI G, BOSI S, CASALI G, MONDUCCI I, BARONE A, PARENTI F, HEYMAN J, COZZI E, BALDACCI G, BACCOS D, BRIGHI F, DESANCTIS A, BOCK R, ROSSI F, AMATI P, SEMPRINI P, NARDELLI A, BOTTERO G, VARTOLO C, MILAZZOTTO F, DICROCE G, DIMARIO F, ANGRISANI G, AZZOLINI P, NEJA CP, MANZOLI U, ROSSI E, TRANI C, MASINI V, SEBASTIANI F, TOPAI M, BORGIA MC, LUCIANI C, FERRI F, DEPAOLA D, CAPURSO S, TUGNOLI F, VETTA C, ALTIERI T, BORZI M, VISCOMI A, STRIANO U, SALITURI S, ZONZIN P, FIORENCIS R, BADIN A, RAVERA B, BALDI C, SILVESTRI F, ALLEMANO P, REYNAUD S, SANSON A, MILANI L, DESIMONE MV, RUSSO A, VILLELLA A, GRAZINI M, AMIDEI S, ANSELMI L, PICCANICOLINO R, MASCELLI G, TAGLIAMONTE A, MESSINA V, TEDESCHI C, BOSSI M, BISIOLI M, TACCHI G, PAGNI G, VIVALDI F, IBBA GV, SANNIA L, PEDRAZZINI F, BAGNI E, FABII S, ALVINO A, ANTONIELLI E, DORONZO B, MARTINENGO E, BECCHI G, SALMOIRAGHI A, DIGIOVANNA F, CARAMANNO G, CAPORICCI D, BRUN M, GIANI P, FERRARIO G, PECI P, RONCONI G, SKOUSE D, GIUSTINIANI S, CUCCHI GF, TAVASCI E, SILVERII A, MARCELLINI G, SPECA G, STANISCIA D, CIMINO A, SERAFINI N, DEBONIS P, CERRUTI P, BAZZUCCHI M, DALPRA F, SPEROTTO C, MOLE GD, BARBANO G, POMARI F, GASCHINO G, PARIGI A, GANDOLFO N, RONDONI F, BRUSCA A, DILEO M, GOLZIO PG, ABRATE M, SCLAVO MG, ROCCI R, POGGIO G, GIANI S, CUZZUCREA D, BRASCHI GB, SCIACCA R, SAMMARTANO A, FURLANELLO F, BRAITO G, CUZZATO V, TOTIS O, FAURETTO F, LEO F, GALATI A, PALMA P, CAMERINI F, MORGERA T, BARBIERI L, SLAVICK GA, FRESCO C, CUDA A, SARNICOLA P, ARZILLO P, BINAGHI G, MACCHI G, CALVERI G, DIMARCO G, LEVANTESI G, PANERAI C, CATURELLI G, FACCHIN L, SARTORE G, ZARDINI P, MARINO P, CARBONIERI E, NAVA S, MAZZINI C, NAVA R, SERRA N, SASSARA M, NICROSINI F, GANDOLFI P, BERGOGNONI G, BALLESTRA AM, and VIOLO C

Subjects
cardiovascular diseases
Abstract

Background. Current knowledge of risk assessment in survivors of myocardial infarction is largely based on data gathered before the advent of thrombolysis. It must be determined whether and to what extent available information and proposed criteria of prognostication are applicable in the thrombolytic era. Methods and Results. We reassessed risk prediction in the 10 219 survivors of myocardial infarction with follow-up data available (ie, 98% of the total) who had been enrolled in the GISSI-2 trial, relying on a set of prespecified variables. The 3.5% 6-month all-cause mortality rate of these patients compared with the higher value of 4.6% found in the corresponding GISSI-1 cohort, originally allocated to streptokinase therapy, indicates a 24% reduction in postdischarge 6-month mortality. On multivariate analysis (Cox model), the following variables were predictors of 6-month all-cause mortality: ineligibility for exercise test for both cardiac (relative risk [RR], 3.30; 95% confidence interval [CI], 2.36-4.62) and noncardiac reasons (RR, 3.28; 95% CI, 2.23-4.72), early left ventricular failure (RR, 2.41; 95% Cl, 1.87-3.09), echocardiographic evidence of recovery phase left ventricular dysfunction (RR, 2.30; 95% CI, 1.78-2.98), advanced (more than 70 years) age (RR, 1.81; 95% Cl, 1.43 -2.30), electrical instability (ie, frequent and/or complex ventricular arrhythmias) (RR, 1.70; 95% Cl, 1.32-2.19), late left ventricular failure (RR, 1.54; 95% Cl, 1.17-2.03), previous myocardial infarction (RR, 1.47; 95% CI, 1.14-1.89), and a history of treated hypertension (RR, 1.32; 95% Cl, 1.05-1.65). Early post-myocardial infarction angina, a positive exercise test, female sex, history of angina, history of insulin-dependent diabetes, and anterior site of myocardial infarction were not risk predictors. On further multivariate analysis, performed on 8315 patients with the echocardiographic indicator of left ventricular dysfunction available, only previous myocardial infarction was not retained as an independent risk predictor. Conclusions. A decline in 6-month mortality of myocardial infarction survivors, seen within 6 hours of symptom onset, has been observed in recent years. Ineligibility for exercise test, early left ventricular failure, and recovery-phase left ventricular dysfunction are the most powerful (RR, >2) predictors of 6-month mortality among patients recovering from myocardial infarction after thrombolysis. Qualitative variables reflecting residual myocardial ischemia do not appear to be risk predictors. The lack of an independent adverse influence of early post-myocardial infarction angina on 6-month survival represents a major difference between this study and those of the prethrombolytic era.

37. The InCosmiCon research center and its activities in the field of SETI, big history and interculturality

Author

Musso, P., Antonietti, N., Asla, M., Wilmer Atachahua, Azcona, G., Benvenuti, P., Francesco, B., Biavaschi, P., Capatinta, M., Ceroni, M., Sánchez, L. C., Crippa, R., Paulis, D., Dutil, Y., Facchetti, G., Facchin, L., Gómez, Á, Gustafson, L., Jordan, A., Laffitte, L., Lagos, D., López, D., Maccone, C., Maspero, G., Melis, A., Montebugnoli, S., Monticelli, R. C. F., Navarro, J., Oliva, J., Pagan, F., Mariotto, F. P., Pereyra, C., Rossi, L., Savio, G., Spiriti, A., Vaidyanathan, B., Valdivia-Silva, J., Vargas, T., González, L. V., Cervantes, V. D. V., Viaña, C., Vianelli, A., Vicentini, A., Vinces, P. V., Zapata, R., and Zumaeta, E.

Subjects
INCOSMICON, SETI, Big History, UCSS-Nopoki, interstellar message, intercultural communication, UCSS-Nopoki, intercultural communication, SETI, Big History, interstellar message, INCOSMICON

39. Seismic markers of the Messinian salinity crisis in the deep Ionian Basin

Author

Angelo Camerlenghi, Riccardo Geletti, Lorenzo Facchin, Marco Saule, Christian Hübscher, Giuseppe Brancatelli, Anna Del Ben, Edy Forlin, Aaron Micallef, Camerlenghi, A., Del Ben, A., Hubscher, C., Forlin, E., Geletti, R., Brancatelli, G., Micallef, A., Saule, M., and Facchin, L.

Subjects
010504 meteorology & atmospheric sciences, Evaporite, Messinian salinity crisis, Signal processing -- Digital techniques, Evaporites, Geomorphology -- Mediterranean Region, Structural basin, evaporites, Mediterranean, 010502 geochemistry & geophysics, 01 natural sciences, Mediterranean Basin, Sedimentary depositional environment, Paleontology, Sill, Messinian salinity crisi, Marl, 14. Life underwater, Sea level, Ionian Basin, 0105 earth and related environmental sciences, geography, geography.geographical_feature_category, evaporite, Geology, Sedimentation and deposition, Sedimentary basin, Salinity -- Mediterranean Region, salt giant, 13. Climate action, Seismic prospecting -- Mediterranean Region, Seismic reflection method
Abstract

We conduct the seismic signal analysis on vintage and recently collected multi-channel seismic reflection profiles from the Ionian Basin to characterize the deep basin Messinian evaporites. These evaporites were deposited in deep and marginal Mediterranean sedimentary basins as a consequence of the “salinity crisis” between 5.97 and 5.33 Ma, a basin‐wide oceanographic and ecological crisis whose origin remains poorly understood. The seismic markers of the Messinian evaporites in the deep Mediterranean basins can be divided in two end‐members, one of which is the typical “trilogy” of gypsum and clastics (Lower Unit – LU), halite (Mobile Unit – MU) and upper anhydrite and marl layers (Upper Unit – UU) traced in the Western Mediterranean Basins. The other end‐member is a single MU unit subdivided in seven sub‐units by clastic interlayers located in the Levant Basin. The causes of these different seismic expressions of the Messinian salinity crisis (MSC) appear to be related to a morphological separation between the two basins by the structural re- gional sill of the Sicily Channel. With the aid of velocity analyses and seismic imag- ing via prestack migration in time and depth domains, we define for the first time the seismic signature of the Messinian evaporites in the deep Ionian Basin, which differs from the known end‐members. In addition, we identify different evaporitic deposi- tional settings suggesting a laterally discontinuous deposition. With the information gathered we quantify the volume of evaporitic deposits in the deep Ionian Basin as 500,000 km3 ± 10%. This figure allows us to speculate that the total volume of salts in the Mediterranean basin is larger than commonly assumed. Different depositional units in the Ionian Basin suggest that during the MSC it was separated from the Western Mediterranean by physical thresholds, from the Po Plain/Northern Adriatic Basin, and the Levant Basin, likely reflecting different hydrological and climatic conditions. Finally, the evidence of erosional surfaces and V‐shaped valleys at the top of the MSC unit, together with sharp evaporites pinch out on evaporite‐free pre‐ Messinian structural highs, suggest an extreme Messinian Stage 3 base level draw down in the Ionian Basin. Such evidence should be carefully evaluated in the light of Messinian and post‐Messinian vertical crustal movements in the area. The results of this study demonstrates the importance of extracting from seismic data the Messinian paleotopography, the paleomorphology and the detailed stratal architecture in the in order to advance in the understanding of the deep basins Messinian depositional environments., peer-reviewed

Published
2019

40. Reconstructed seismic and tsunami scenarios of the 1905 Calabria earthquake (SE Tyrrhenian sea) as a tool for geohazard assessment

Author

Francesco Muto, Gianluca Pagnoni, Stefano Tinti, F. Zgur, Lorenzo Facchin, Franco Pettenati, Maria Filomena Loreto, Fabrizio Brutto, Denis Sandron, Alberto Armigliato, Loreto, M.F., Pagnoni, G., Pettenati, F., Armigliato, A., Tinti, S., Sandron, D., Brutto, F., Muto, F., Facchin, L., and Zgur, F.

Subjects
KF-scenario, KF-scenarios, 010504 meteorology & atmospheric sciences, risk analysis, Tsunami scenario, environmental effects, active tectonics, Active fault, 010502 geochemistry & geophysics, 01 natural sciences, Risk analysi, Earthquake scenario, Active tectonic, Urban planning, Urban seismic risk, Environmental effect, Risk management, 0105 earth and related environmental sciences, business.industry, 1905 Calabria earthquake, Geology, Geotechnical Engineering and Engineering Geology, Submarine pipeline, Deterministic analysis, Geohazard, business, Seismology
Abstract

Italy is one of the most seismically active regions in the central Mediterranean and one of the countries with the longest record of historical earthquakes in the world. Over the last decades the scientific community has recognised the value of historical data when used to constrain modelling tools in hazard analyses. This is the case of the destructive 1905 Calabria (South Italy) earthquake, followed by a tsunami and by many secondary effects on the environment observed both inland and offshore. Recently acquired geophysical data allowed to identify an active normal fault, named Sant'Eufemia Fault, located nearshore in the Sant'Eufemia Gulf (SE Tyrrhenian sea), considered the most probable seismogenic source of the 1905 earthquake and capable to trigger future events. In this paper we perform a scenario-based deterministic analysis for an earthquake resulting from the rupture of the Sant'Eufemia fault (SEF) and a preliminary potential risk analysis. After defining source parameters compatible with the 1905 earthquake (ca. 40 km fault length and ca. 2.3 m slip, Mw 6.9), KF-analysis and tsunami simulations are carried out and modelling results are compared against historical available data. The obtained results allow one to border areas in central Calabria that are most exposed to geohazard deriving from the analyzed fault. Some of these areas happen to be zones with intense economic/touristic and urban development, which calls for the need to integrate the ongoing development plans with adequate programs of risk mitigation and prevention.

Published
2017

41. The marine activities performed within the TOMO-ETNA experiment

Author

F. Zgur, Rita Blanos, Maria Eloisa Claude, Maria Teresa Pedrosa Gonzales, Lorenzo Sormani, Cosmo Carmisciano, Attilio Sulli, Antonino D'Alessandro, Teresa Teixidó, Fausto Grassa, Lorenzo Facchin, Diego Cotterle, Mauro Coltelli, S. Speciale, R. D'Anna, S. Rapisarda, Aristomenis P. Karageorgis, Luca Cocchi, Gioacchino Fertitta, Marco Firetto Carlino, G. Passafiume, Giuseppe D'Anna, Giampaolo Visnovic, Domenico Patanè, Clara Monaco, Francisco Carrión, F. Cultrera, Paolo Mansutti, Jesús M. Ibáñez, Filippo Muccini, Danilo Cavallaro, Coltelli, M., Cavallaro, D., Carlino, M., Cocchi, L., Muccini, F., D’Alessandro, A., Claude, M., Monaco, C., Ibáñez, J., Zgur, F., Patanè, D., Carmisciano, C., D’Anna, G., Gonzales, M., Teixidó, T., D’Anna, R., Fertitta, G., Passafiume, G., Speciale, S., Grassa, F., Karageorgis, A., Sormani, L., Facchin, L., Visnovic, G., Cotterle, D., Blanos, R., Mansutti, P., Sulli, A., Cultrera, F., Carrión, F., and Rapisarda, S.

Subjects
0301 basic medicine, Seismometer, lcsh:QC851-999, 010502 geochemistry & geophysics, Remotely operated vehicle, 01 natural sciences, Sonar, Gravity anomaly, Etna offshore, Ionian and Tyrrhenian Seas, Marine geophysical data acquisition, Scientific cruise report, Geophysics, 03 medical and health sciences, Seismic refraction, 0105 earth and related environmental sciences, lcsh:QC801-809, Ionian and Tyrrhenian Sea, Seafloor spreading, lcsh:Geophysics. Cosmic physics, 030104 developmental biology, Seismic tomography, lcsh:Meteorology. Climatology, Submarine pipeline, Geology, Seismology
Abstract

The TOMO-ETNA experiment was planned in order to obtain a detailed geological and structural model of the continental and oceanic crust beneath Mt. Etna volcano and northeastern Sicily up to the Aeolian Islands (southern Italy), by integrating data from active and passive refraction and reflection seismic methodologies, magnetic and gravity surveys. This paper focuses on the marine activities performed within the experiment, which have been carried out in the Ionian and Tyrrhenian Seas, during three multidisciplinary oceanographic cruises, involving three research vessels (“Sarmiento de Gamboa”, “Galatea” and “Aegaeo”) belonging to different countries and institutions. During the offshore surveys about 9700 air-gun shots were produced to achieve a high-resolution seismic tomography through the wide-angle seismic refraction method, covering a total of nearly 2650 km of shooting tracks. To register ground motion, 27 ocean bottom seismometers were deployed, extending the inland seismic permanent network of the Istituto Nazionale di Geofisica e Vulcanologia and a temporary network installed for the experiment. A total of 1410 km of multi-channel seismic reflection profiles were acquired to image the subsurface of the area and to achieve a 2D velocity model for each profile. Multibeam sonar and sub bottom profiler data were also collected. Moreover, a total of 2020 km of magnetic and 680 km of gravity track lines were acquired to compile magnetic and gravity anomaly maps offshore Mt. Etna volcano. Here, high-resolution images of the seafloor, as well as sediment and rock samples, were also collected using a remotely operated vehicle.

Published
2016

42. Slow Waves Promote Sleep-Dependent Plasticity and Functional Recovery after Stroke.

Author

Facchin L, Schöne C, Mensen A, Bandarabadi M, Pilotto F, Saxena S, Libourel PA, Bassetti CLA, and Adamantidis AR

Subjects
Animals, Axons pathology, Cerebral Cortex physiopathology, Cerebral Infarction physiopathology, Electroencephalography, Ischemic Stroke psychology, Male, Mice, Mice, Inbred C57BL, Muscle Strength, Nerve Net physiopathology, Optogenetics, Psychomotor Performance, Pyramidal Cells, Recovery of Function, Ischemic Stroke physiopathology, Neuronal Plasticity, Sleep, Slow-Wave, Stroke Rehabilitation
Abstract

Functional recovery after stroke is associated with a remapping of neural circuits. This reorganization is often associated with low-frequency, high-amplitude oscillations in the peri-infarct zone in both rodents and humans. These oscillations are reminiscent of sleep slow waves (SW) and suggestive of a role for sleep in brain plasticity that occur during stroke recovery; however, direct evidence is missing. Using a stroke model in male mice, we showed that stroke was followed by a transient increase in NREM sleep accompanied by reduced amplitude and slope of ipsilateral NREM sleep SW. We next used 5 ms optical activation of Channelrhodopsin 2-expressing pyramidal neurons, or 200 ms silencing of Archeorhodopsin T-expressing pyramidal neurons, to generate local cortical UP, or DOWN, states, respectively, both sharing similarities with spontaneous NREM SW in freely moving mice. Importantly, we found that single optogenetically evoked SW (SW opto ) in the peri-infarct zone, randomly distributed during sleep, significantly improved fine motor movements of the limb corresponding to the sensorimotor stroke lesion site compared with spontaneous recovery and control conditions, while motor strength remained unchanged. In contrast, SW opto during wakefulness had no effect. Furthermore, chronic SW opto during sleep were associated with local axonal sprouting as revealed by the increase of anatomic presynaptic and postsynaptic markers in the peri-infarct zone and corresponding contralesional areas to cortical circuit reorganization during stroke recovery. These results support a role for sleep SW in cortical circuit plasticity and sensorimotor recovery after stroke and provide a clinically relevant framework for rehabilitation strategies using neuromodulation during sleep. SIGNIFICANCE STATEMENT Brain stroke is one of the leading causes of death and major disabilities in the elderly worldwide. A better understanding of the pathophysiological mechanisms underlying spontaneous brain plasticity after stroke, together with an optimization of rehabilitative strategies, are essential to improve stroke treatments. Here, we investigate the role of optogenetically induced sleep slow waves in an animal model of ischemic stroke and identify sleep as a window for poststroke intervention that promotes neuroplasticity and facilitates sensorimotor recovery., (Copyright © 2020 Facchin et al.)

Published
2020
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44. Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches.

Author

Mensen A, Pigorini A, Facchin L, Schöne C, D'Ambrosio S, Jendoubi J, Jaramillo V, Chiffi K, Eberhard-Moscicka AK, Sarasso S, Adamantidis A, Müri RM, Huber R, Massimini M, and Bassetti C

Subjects
Humans, Observational Studies as Topic, Neuronal Plasticity physiology, Recovery of Function physiology, Sleep physiology, Stroke physiopathology
Abstract

Our own experiences with disturbances to sleep demonstrate its crucial role in the recovery of cognitive functions. This importance is likely enhanced in the recovery from stroke; both in terms of its physiology and cognitive abilities. Decades of experimental research have highlighted which aspects and mechanisms of sleep are likely to underlie these forms of recovery. Conversely, damage to certain areas of the brain, as well as the indirect effects of stroke, may disrupt sleep. However, only limited research has been conducted which seeks to directly explore this bidirectional link between both the macro and micro-architecture of sleep and stroke. Here we describe a series of semi-independent approaches that aim to establish this link through observational, perturbational, and interventional experiments. Our primary aim is to describe the methodology for future clinical and translational research needed to delineate competing accounts of the current data. At the observational level we suggest the use of high-density EEG recording, combined analysis of macro and micro-architecture of sleep, detailed analysis of the stroke lesion, and sensitive measures of functional recovery. The perturbational approach attempts to find the causal links between sleep and stroke. We promote the use of transcranial magnetic stimulation combined with EEG to examine the cortical dynamics of the peri-infarct stroke area. Translational research should take this a step further using optogenetic techniques targeting more specific cell populations. The interventional approach focuses on how the same clinical and translational perturbational techniques can be adapted to influence long-term recovery of function., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2019
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45. Sleep-Wake Disorders in Stroke-Increased Stroke Risk and Deteriorated Recovery? An Evaluation on the Necessity for Prevention and Treatment.

Author

Duss SB, Brill AK, Bargiotas P, Facchin L, Alexiev F, Manconi M, and Bassetti CL

Subjects
Brain Injuries complications, Cognition, Humans, Quality of Life, Risk Factors, Sleep Initiation and Maintenance Disorders complications, Sleep Wake Disorders therapy, Sleep Apnea Syndromes complications, Sleep Wake Disorders complications, Stroke complications, Stroke prevention & control
Abstract

Purpose of Review: Sleep-wake disorders (SWD) are common not only in the general population but also in stroke patients, in whom SWD may be pre-existent or appear "de novo" as a consequence of brain damage. Despite increasing evidence of a negative impact of SWD on cardiocerebrovascular risk, cognitive functions, and quality of life, SWD are insufficiently considered in the prevention and management of patients with stroke. This narrative review aims at summarizing the current data on the bidirectional link between SWD and stroke., Recent Findings: Several studies have demonstrated that sleep-disordered breathing (SDB) is an independent risk factor for stroke and has a detrimental effect on stroke recovery. Short and long sleep duration and possibly other SWD (e.g., insomnia, circadian rhythm disorders) may also increase the risk of stroke and influence its outcome. Data on SDB treatment increasingly indicate a benefit on stroke risk and evolution while treatment of other SWD is still limited. A systematic search for SWD in stroke patients is justified due to their high frequency and their negative impact on stroke outcomes. Clinicians should actively consider available treatment options.

Published
2018
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46. Evidence of the Zanclean megaflood in the eastern Mediterranean Basin.

Author

Micallef A, Camerlenghi A, Garcia-Castellanos D, Cunarro Otero D, Gutscher MA, Barreca G, Spatola D, Facchin L, Geletti R, Krastel S, Gross F, and Urlaub M

Abstract

The Messinian salinity crisis (MSC) - the most abrupt, global-scale environmental change since the end of the Cretaceous - is widely associated with partial desiccation of the Mediterranean Sea. A major open question is the way normal marine conditions were abruptly restored at the end of the MSC. Here we use geological and geophysical data to identify an extensive, buried and chaotic sedimentary body deposited in the western Ionian Basin after the massive Messinian salts and before the Plio-Quaternary open-marine sedimentary sequence. We show that this body is consistent with the passage of a megaflood from the western to the eastern Mediterranean Sea via a south-eastern Sicilian gateway. Our findings provide evidence for a large amplitude drawdown in the Ionian Basin during the MSC, support the scenario of a Mediterranean-wide catastrophic flood at the end of the MSC, and suggest that the identified sedimentary body is the largest known megaflood deposit on Earth.

Published
2018
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47. Sleep, Preconditioning and Stroke.

Author

Pincherle A, Pace M, Sarasso S, Facchin L, Dreier JP, and Bassetti CL

Subjects
Animals, Brain Ischemia complications, Disease Models, Animal, Stroke epidemiology, Brain Ischemia prevention & control, Ischemic Preconditioning, Sleep physiology, Stroke prevention & control
Published
2017
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48. ADALIMUMAB FOR ULCERATIVE COLITIS: RESULTS OF A BRAZILIAN MULTICENTER OBSERVATIONAL STUDY.

Author

Zacharias P, Damião AOMC, Moraes AC, Teixeira FV, Ludvig JC, Nones RB, Saad-Hossne R, Sassaki LY, Silva RPLD, Facchin L, Olandoski M, and Kotze PG

Subjects
Adolescent, Adult, Aged, Female, Humans, Longitudinal Studies, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Young Adult, Adalimumab therapeutic use, Anti-Inflammatory Agents therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Colitis, Ulcerative drug therapy
Abstract

Background: Adalimumab is a monoclonal antibody, tumor necrosis factor-alpha (TNFα) inhibitor that has efficacy for inducing and maintaining remission in moderate-to-severe ulcerative colitis. Real world studies with adalimumab in Latin American ulcerative colitis patients are scarce., Objective: To assess the clinical remission rates in induction and maintenance with adalimumab therapy in ulcerative colitis., Methods: Observational, multicenter and retrospective study on a case series of patients with moderate-to-severe ulcerative colitis under adalimumab therapy. The variables analyzed were: demographic data, previous infliximab status, concomitant drugs, the Montreal Classification, disease activity (Mayo score) at weeks 0, 8, 26 and 52, or until the last follow-up. Clinical remission was defined as a partial Mayo score ≤2 and Last observation carried forward (LOCF) and Non responder imputation (NRI) analysis were used., Results: Thirty-six patients were included in the study. With LOCF analysis, remission rates at weeks 8, 26 e 52 were of 41.7%, 47.2% and 47.2%, respectively. With NRI analysis, remission rates at weeks 8, 26 and 52 were of 41.7%, 41.7% and 27.8%, respectively., Conclusion: Adalimumab was effective in the treatment of moderate-to-severe ulcerative colitis. Clinical remission was observed in approximately 40% of the patients at weeks 8 and 26, and in almost a quarter of the patients after 1 year of follow up.

Published
2017
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49. Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-Ischemia.

Author

Pace M, Adamantidis A, Facchin L, and Bassetti C

Subjects
Animals, Electroencephalography, Electromyography, Gene Expression, Hypothalamic Hormones genetics, Male, Melanins genetics, Orexins genetics, Pituitary Hormones genetics, Prognosis, Rats, Sprague-Dawley, Stroke genetics, Hypothalamic Hormones physiology, Melanins physiology, Orexins physiology, Pituitary Hormones physiology, Sleep Deprivation, Sleep, REM, Stroke physiopathology
Abstract

Study Objectives: Sleep reduction after stroke is linked to poor recovery in patients. Conversely, a neuroprotective effect is observed in animals subjected to acute sleep deprivation (SD) before ischemia. This neuroprotection is associated with an increase of the sleep, melanin concentrating hormone (MCH) and orexin/hypocretin (OX) systems. This study aims to 1) assess the relationship between sleep and recovery; 2) test the association between MCH and OX systems with the pathological mechanisms of stroke., Methods: Sprague-Dawley rats were assigned to four experimental groups: (i) SD&#95;IS: SD performed before ischemia; (ii) IS: ischemia; (iii) SD&#95;Sham: SD performed before sham surgery; (iv) Sham: sham surgery. EEG and EMG were recorded. The time-course of the MCH and OX gene expression was measured at 4, 12, 24 hours and 3, 4, 7 days following ischemic surgery by qRT-PCR., Results: A reduction of infarct volume was observed in the SD&#95;IS group, which correlated with an increase of REM sleep observed during the acute phase of stroke. Conversely, the IS group showed a reduction of REM sleep. Furthermore, ischemia induces an increase of MCH and OX systems during the acute phase of stroke, although, both systems were still increased for a long period of time only in the SD&#95;IS group., Conclusions: Our data indicates that REM sleep may be involved in the neuroprotective effect of SD pre-ischemia, and that both MCH and OX systems were increased during the acute phase of stroke. Future studies should assess the role of REM sleep as a prognostic marker, and test MCH and OXA agonists as new treatment options in the acute phase of stroke., Competing Interests: The authors have declared that no competing interests exist.

Published
2017
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50. Disruption of Epithalamic Left-Right Asymmetry Increases Anxiety in Zebrafish.

Author

Facchin L, Duboué ER, and Halpern ME

Subjects
Adaptation, Biological, Animals, Animals, Genetically Modified, Anti-Anxiety Agents pharmacology, Anti-Anxiety Agents therapeutic use, Anxiety drug therapy, Anxiety genetics, Buspirone pharmacology, Buspirone therapeutic use, Cues, Disease Models, Animal, Exploratory Behavior drug effects, Exploratory Behavior physiology, Forkhead Transcription Factors genetics, Forkhead Transcription Factors metabolism, Hydrocortisone metabolism, Imitative Behavior drug effects, Imitative Behavior physiology, Larva, Locomotion, Photic Stimulation, Pineal Gland physiology, Pineal Gland surgery, Zebrafish, Zebrafish Proteins genetics, Zebrafish Proteins metabolism, Anxiety pathology, Epithalamus pathology, Functional Laterality physiology
Abstract

Differences between the left and right sides of the brain are found throughout the animal kingdom, but the consequences of altered neural asymmetry are not well understood. In the zebrafish epithalamus, the parapineal is located on the left side of the brain where it influences development of the adjacent dorsal habenular (dHb) nucleus, causing the left and right dHb to differ in their organization, gene expression, and connectivity. Left-right (L-R) reversal of parapineal position and dHb asymmetry occurs spontaneously in a small percentage of the population, whereas the dHb develop symmetrically following experimental ablation of the parapineal. The habenular region was previously implicated in modulating fear in both mice and zebrafish, but the relevance of its L-R asymmetry is unclear. We now demonstrate that disrupting directionality of the zebrafish epithalamus causes reduced exploratory behavior and increased cortisol levels, indicative of enhanced anxiety. Accordingly, exposure to buspirone, an anxiolytic agent, significantly suppresses atypical behavior. Axonal projections from the parapineal to the dHb are more variable when it is located on the right side of the brain, revealing that L-R reversals do not necessarily represent a neuroanatomical mirror image. The results highlight the importance of directional asymmetry of the epithalamus in the regulation of stress responses in zebrafish., (Copyright © 2015 the authors 0270-6474/15/3515847-13$15.00/0.)

Published
2015
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