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46 results on '"Fabo, Dániel"'

4. Manifold-adaptive dimension estimation revisited

Author

Benkő, Zsigmond, Stippinger, Marcell, Rehus, Roberta, Bencze, Attila, Fabó, Dániel, Hajnal, Boglárka, Erőss, Loránd, Telcs, András, and Somogyvári, Zoltán

Subjects
Statistics - Methodology, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Data dimensionality informs us about data complexity and sets limit on the structure of successful signal processing pipelines. In this work we revisit and improve the manifold-adaptive Farahmand-Szepesv\'ari-Audibert (FSA) dimension estimator, making it one of the best nearest neighbor-based dimension estimators available. We compute the probability density function of local FSA estimates, if the local manifold density is uniform. Based on the probability density function, we propose to use the median of local estimates as a basic global measure of intrinsic dimensionality, and we demonstrate the advantages of this asymptotically unbiased estimator over the previously proposed statistics: the mode and the mean. Additionally, from the probability density function, we derive the maximum likelihood formula for global intrinsic dimensionality, if i.i.d. holds. We tackle edge and finite-sample effects with an exponential correction formula, calibrated on hypercube datasets. We compare the performance of the corrected-median-FSA estimator with kNN estimators: maximum likelihood (ML, Levina-Bickel) and two implementations of DANCo (R and matlab). We show that corrected-median-FSA estimator beats the ML estimator and it is on equal footing with DANCo for standard synthetic benchmarks according to mean percentage error and error rate metrics. With the median-FSA algorithm, we reveal diverse changes in the neural dynamics while resting state and during epileptic seizures. We identify brain areas with lower-dimensional dynamics that are possible causal sources and candidates for being seizure onset zones.

Published
2020
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7. Complete Inference of Causal Relations between Dynamical Systems

Author

Benkő, Zsigmond, Zlatniczki, Ádám, Stippinger, Marcell, Fabó, Dániel, Sólyom, András, Erőss, Loránd, Telcs, András, and Somogyvári, Zoltán

Subjects
Quantitative Biology - Quantitative Methods, Quantitative Biology - Neurons and Cognition
Abstract

From ancient philosophers to modern economists, biologists, and other researchers, there has been a continuous effort to unveil causal relations. The most formidable challenge lies in deducing the nature of the causal relationship: whether it is unidirectional, bidirectional, or merely apparent - implied by an unobserved common cause. While modern technology equips us with tools to collect data from intricate systems such as the planet's ecosystem or the human brain, comprehending their functioning requires the identification and differentiation of causal relationships among the components, all without external interventions. In this context, we introduce a novel method capable of distinguishing and assigning probabilities to the presence of all potential causal relations between two or more time series within dynamical systems. The efficacy of this method is verified using synthetic datasets and applied to EEG (electroencephalographic) data recorded from epileptic patients. Given the universal applicability of our method, it holds promise for diverse scientific fields.

Published
2018

14. EEG in fitness to drive evaluations in people with epilepsy — Considerable variations across Europe

Author

Markhus, Rune, Henning, Oliver, Molteberg, Ellen, Hećimović, Hrvoje, Ujvari, Akos, Hirsch, Edouard, Rheims, Sylvain, Surges, Rainer, Malmgren, Kristina, Rüegg, Stephan, Gil-Nagel, Antonio, Roivainen, Reina, Picard, Fabienne, Steinhoff, Bernhard, Marusic, Petr, Mostacci, Barbara, Kimiskidis, Vasilios K., Mindruta, Ioana, Jagella, Caroline, Mameniškienė, Rūta, Schulze-Bonhage, Andreas, Rosenow, Felix, Kelemen, Anna, Fabo, Daniel, Walker, Matthew C., Seeck, Margitta, Krämer, Günter, Arsene, Oana Tarta, Krestel, Heinz, and Lossius, Morten

Published
2020
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15. The generation and propagation of the human alpha rhythm

Author

Halgren, Milan, Ulbert, István, Bastuji, Hélène, Fabó, Dániel, Erőss, Lorand, Rey, Marc, Devinsky, Orrin, Doyle, Werner K., Mak-McCully, Rachel, Halgren, Eric, Wittner, Lucia, Chauvel, Patrick, Heit, Gary, Eskandar, Emad, Mandell, Arnold, and Cash, Sydney S.

Published
2019

16. Modeling Neuronal Firing in Epilepsy: Fitting Hawkes Processes to Single-Unit Activity

Author

Perczel, György, Erőss, Loránd, Fabó, Dániel, Gerencsér, László, Vágó, Zsuzsanna, Bock, Hans Georg, Series Editor, de Hoog, Frank, Series Editor, Friedman, Avner, Series Editor, Gupta, Arvind, Series Editor, Nachbin, André, Series Editor, Ozawa, Tohru, Series Editor, Pulleyblank, William R., Series Editor, Rusten, Torgeir, Series Editor, Santosa, Fadil, Series Editor, Seo, Jin Keun, Series Editor, Tornberg, Anna-Karin, Series Editor, Faragó, István, editor, Izsák, Ferenc, editor, and Simon, Péter L., editor

Published
2019
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23. Current practices in long-term video-EEG monitoring services: A survey among partners of the E-PILEPSY pilot network of reference for refractory epilepsy and epilepsy surgery

Author

Kobulashvili, Teia, Höfler, Julia, Dobesberger, Judith, Ernst, Florian, Ryvlin, Philippe, Cross, J Helen, Braun, Kees, Dimova, Petia, Francione, Stefano, Hecimovic, Hrvoje, Helmstaedter, Christoph, Kimiskidis, Vasilios K., Lossius, Morten Ingvar, Malmgren, Kristina, Marusic, Petr, Steinhoff, Bernhard J., Boon, Paul, Craiu, Dana, Delanty, Norman, Fabo, Daniel, Gil-Nagel, Antonio, Guekht, Alla, Hirsch, Edouard, Kalviainen, Reetta, Mameniskiené, Ruta, Özkara, Çiğdem, Seeck, Margitta, Rubboli, Guido, Krsek, Pavel, Rheims, Sylvain, and Trinka, Eugen

Published
2016
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25. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry

Author

Peltola, Jukka, Colon, Albert J., Pimentel, José, Coenen, Volker A., Gil-Nagel, Antonio, Gonçalves Ferreira, António, Lehtimäki, Kai, Ryvlin, Philippe, Taylor, Rod S., Ackermans, Linda, Ardesch, Jacqueline, Bentes, Carla, Bosak, Magdalena, Burneo, Jorge G., Chamadoira, Clara, Elger, Christian E., Erőss, Loránd, Fabo, Dániel, Faulkner, Howard, Gawlowicz, Jacek, Gharabaghi, Alireza, Iacoangeli, Maurizio, Janszky, Jozsef, Järvenpää, Soila, Kaufmann, Elisabeth, Kho, Kuan H., Kumlien, Eva, Laufs, Helmut, Lettieri, Christian, Linhares, Paulo, Noachtar, Soheyl, Parrent, Andrew, Pataraia, Ekaterina, Patel, Nikunj K., Peralta, Ana, Rácz, Attila, Rainha Campos, Alexandre, Rego, Ricardo, Ricciuti, Riccardo A., Rona, Sabine, Rouhl, Rob P.W., Schulze-Bonhage, Andreas, Schuurman, Rick, Sprengers, Mathieu, Sufianov, Albert, Temel, Yasin, Theys, Tom, Van Paesschen, Wim, Van Roost, Dirk, Vaz, Rui, Vonck, Kristl, Wagner, Louis, Zwemmer, Jack, Abouihia, Abdallah, Brionne, Thomas C., Gielen, Frans, Boon, Paul A.J.M., Tampere University, Clinical Medicine, Department of Neurosciences and Rehabilitation, and Repositório da Universidade de Lisboa

Subjects
Medicine and Health Sciences, Neurology (clinical), 3124 Neurology and psychiatry
Abstract

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Background and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice. Methods: MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes. Results: Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years (p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years (p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported. Discussion: The MORE registry supports the effectiveness and safety of ANT DBS therapy in a real-world setting in the 2 years following implantation. Classification of evidence: This study provides Class IV evidence that ANT DBS reduces the frequency of seizures in patients with drug-resistant focal epilepsy., The MORE registry was sponsored and funded by Medtronic, plc.

Published
2023

46. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry.

Author

Peltola J, Colon AJ, Pimentel J, Coenen VA, Gil-Nagel A, Gonçalves Ferreira A, Lehtimäki K, Ryvlin P, Taylor RS, Ackermans L, Ardesch J, Bentes C, Bosak M, Burneo JG, Chamadoira C, Elger CE, Erőss L, Fabo D, Faulkner H, Gawlowicz J, Gharabaghi A, Iacoangeli M, Janszky J, Järvenpää S, Kaufmann E, Kho KH, Kumlien E, Laufs H, Lettieri C, Linhares P, Noachtar S, Parrent A, Pataraia E, Patel NK, Peralta AR, Rácz A, Campos AR, Rego R, Ricciuti RA, Rona S, Rouhl RPW, Schulze-Bonhage A, Schuurman R, Sprengers M, Sufianov A, Temel Y, Theys T, Van Paesschen W, Van Roost D, Vaz R, Vonck K, Wagner L, Zwemmer J, Abouihia A, Brionne TC, Gielen F, and Boon PAJM

Subjects
Humans, Female, Child, Adolescent, Male, Quality of Life, Retrospective Studies, Prospective Studies, Thalamus, Seizures etiology, Registries, Deep Brain Stimulation adverse effects, Epilepsy etiology, Drug Resistant Epilepsy therapy, Anterior Thalamic Nuclei
Abstract

Background and Objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice., Methods: MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes., Results: Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years ( p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years ( p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported., Discussion: The MORE registry supports the effectiveness and safety of ANT DBS therapy in a real-world setting in the 2 years following implantation., Classification of Evidence: This study provides Class IV evidence that ANT DBS reduces the frequency of seizures in patients with drug-resistant focal epilepsy., Trial Registration Information: MORE ClinicalTrials.gov Identifier: NCT01521754, first posted on January 31, 2012., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)

Published
2023
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