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Nitrogen-based heterocycles such as pyrazole, imidazole, 1,2,4-triazole, benzimidazole, and benzotriazole substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e, & 14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines. Among the compounds, 6e, 14b, and 8c were identified as the most potent against MCF7, A549, and HCT116, with IC50 values of 12.46 ± 2.72 μM, 0.23 ± 0.12 μM, and 7.58 ± 1.01 μM, respectively. Further studies demonstrated that these compounds can change cellular and nuclear morphology and inhibit colony formation in the tested cancer cells. They also remarkably block/inhibit the cell cycle progression of cancer cells at various phases. DNA damage analysis and apoptosis studies revealed that these compounds have the potential to induce DNA double-strand breaks and apoptosis. In silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the potent compounds were assessed, revealing that all the compounds exhibited favorable pharmacokinetic and toxicological properties. The potent compounds identified from this study can be considered as a lead for further drug design and development. [ABSTRACT FROM AUTHOR]

Emerging multi-drug resistance (MDR) bacteria are alarming the medicinal chemistry community to establish a new class of antimicrobials with high selectivity, less toxicity, and a new mode of action. Therefore, a new series of chalcone-morpholine hybrids (6a–p) were synthesized using copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition to link the above two pharmacophores with the 1,2,3-triazole ring. Antibacterial potentials of all the synthesized compounds were studied against two Gram-positive (Bacillus subtilis and Staphylococcus aureus), and three Gram-negative (Escherichia coli, Pseudomonas putida, and Klebsiella pneumonia) bacterial strains. Among the tested series of compounds, 6a, 6c, and 6m against all the bacterial strains, 6e against both the Gram-positive bacteria, and 6h against all the Gram-negative bacteria were found to exhibit broad-spectrum activity compared with the standard Ampicillin. Furthermore, in silico ADME profiles were also predicted to set effective lead candidates for effective antibacterial agents. [ABSTRACT FROM AUTHOR]

Highly crystalline and smooth 1% Ho3+ doped ZnO microspheres with diameters ranging from 0.5 to 15 μm were synthesized using laser ablation technique. Near band edge whispering gallery mode (WGM) resonances from Ho:ZnO microspheres with a single oscillation route in the UV range are observed with 355 nm excitation. Apart from the significantly enhanced visible WGM resonances associated with intrinsic oxygen vacancy defects by Ho3+ doping, the visible range WGM resonances associated with the Ho3+ 5F5 → 5I8 emission at 629–690 nm are also observed with a 488 nm excitation. The WGMs of Ho3+ f-f emission possess lower threshold and high Q-factor values. [ABSTRACT FROM AUTHOR]