106 results on '"Fabian, Frank"'
Search Results
2. Professional relationships during crisis interventions: A scoping review.
- Author
-
Larissa Steimle, Sebastian von Peter, and Fabian Frank
- Subjects
Medicine ,Science - Abstract
IntroductionA crisis can be described as subjective experience that threatens and overwhelms a person's ability to handle a specific situation. In dealing with crises some people are looking for support from professionals. The "professional relationship" between people experiencing a crisis and professionals plays an important role in the successful management of a crisis which has been widely researched in many contexts. However, regarding outpatient services (e. g. crisis resolution home treatment teams), yet empirical evidence remains limited.ObjectiveWe aim to explore descriptions of supportive professional relationships during outpatient crisis interventions in empirical literature. Accordingly, a scoping review was conducted to identify types of evidence, map the key concepts, and point out research gaps.MethodsMEDLINE, PsycINFO, CINAHL and Social Science Citation Index were searched for studies reporting empirical data on the professional relationship between people experiencing a crisis (18+) and professionals (e. g. social workers, psychiatrists) during a crisis intervention, defined as a short-term, face-to-face, low threshold, time-limited, outpatient, and voluntary intervention to cope with crises. Studies were excluded if they were published before 2007, in languages other than English and German, and if they couldn't be accessed. Included studies were summarized, compared, and synthesized using qualitative content analyses.Results3.741 records were identified, of which 8 met the eligibility criteria. Only one study directly focused on the relationship; the others addressed varied aspects. Two studies explored the perspectives of service users, five focused on those of the professionals and one study examined both. The empirical literature was categorized into three main themes: strategies used to develop a supportive professional relationship, factors influencing the relationship and the nature of these relationships.DiscussionThe results reveal a gap in understanding the nature of supportive professional relationships from the service users' perspective, as well as how professionals construct these relationships.
- Published
- 2024
- Full Text
- View/download PDF
3. Enhanced Antifibrinolytic Efficacy of a Plasmin-Specific Kunitz-Inhibitor (60-Residue Y11T/L17R with C-Terminal IEK) of Human Tissue Factor Pathway Inhibitor Type-2 Domain1.
- Author
-
Vadivel, Kanagasabai, Zaiss, Anne, Kumar, Yogesh, Fabian, Frank, Ismail, Ayman, Arbing, Mark, Buchholz, Wallace, Velander, William, and Bajaj, S
- Subjects
antifibrinolytics ,aprotinin ,thromboelastography ,tranexamic acid ,ε-aminocaproic acid - Abstract
Current antifibrinolytic agents reduce blood loss by inhibiting plasmin active sites (e.g., aprotinin) or by preventing plasminogen/tissue plasminogen activator (tPA) binding to fibrin clots (e.g., ε-aminocaproic acid and tranexamic acid); however, they have adverse side effects. Here, we expressed 60-residue (NH2NAE…IEKCOOH) Kunitz domain1 (KD1) mutants of human tissue factor pathway inhibitor type-2 that inhibit plasmin as well as plasminogen activation. A single (KD1-L17R-KCOOH) and a double mutant (KD1-Y11T/L17R- KCOOH) were expressed in Escherichia coli as His-tagged constructs, each with enterokinase cleavage sites. KD1-Y11T/L17R-KCOOH was also expressed in Pichia pastoris. KD1-Y11T/L17R-KCOOH inhibited plasmin comparably to aprotinin and bound to the kringle domains of plasminogen/plasmin and tPA with Kd of ~50 nM and ~35 nM, respectively. Importantly, compared to aprotinin, KD1-L17R-KCOOH and KD1-Y11T/L17R-KCOOH did not inhibit kallikrein. Moreover, the antifibrinolytic potential of KD1-Y11T/L17R-KCOOH was better than that of KD1-L17R-KCOOH and similar to that of aprotinin in plasma clot-lysis assays. In thromboelastography experiments, KD1-Y11T/L17R-KCOOH was shown to inhibit fibrinolysis in a dose dependent manner and was comparable to aprotinin at a higher concentration. Further, KD1-Y11T/L17R-KCOOH did not induce cytotoxicity in primary human endothelial cells or fibroblasts. We conclude that KD1-Y11T/L17R-KCOOH is comparable to aprotinin, the most potent known inhibitor of plasmin and can be produced in large amounts using Pichia.
- Published
- 2020
4. Local, collaborative, stepped, and personalized care management for older people with chronic diseases – results from the randomized controlled LoChro-trial
- Author
-
Gloria Metzner, Lukas Maximilian Horstmeier, Jürgen Bengel, Eva Maria Bitzer, Elena Dreher, Fabian Frank, Anne Göhner, Bernhard Heimbach, Ines Himmelsbach, Klaus Kaier, Jasmin Kiekert, Katharina Kohler, Katharina Laubner, Lisa Lyssenko, Andy Maun, Christoph Maurer, Claudia Salm, Jochen Seufert, Sebastian Voigt-Radloff, and Erik Farin-Glattacker
- Subjects
Collaborative care ,Care management ,Intervention ,Older adults ,Chronic diseases ,Multimorbidity ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background In the aging population of Western societies, an increasing number of older adults have multiple chronic diseases. As multifaceted health problems imply the involvement of several healthcare professionals, multimorbid older people frequently face a fragmentation of health care. Addressing these challenges, we developed a local, collaborative, stepped, and personalized care management approach (LoChro-Care) and evaluated its effectiveness. Methods A two-group, parallel randomized controlled trial was conducted comparing LoChro-Care recipients (IG) to participants with usual care (CG). Patients aged 65 + with chronic conditions were recruited at inpatient and outpatient departments of the Medical Center, University of Freiburg. Participants were allocated using block randomization (nIG = 261, nCG = 263). LoChro-Care comprised individualized care provided by chronic care managers with 7 to 13 contacts over 12 months. Questionnaires were given at 3 time points (T0: baseline, T1: after 12 months, T2: after 18 months). The primary outcome was the physical, psychological, and social health status represented by a composite score of functional health and depressive symptoms. Secondary outcomes were the participants’ evaluation of their health care situation, health-related quality of life (HRQL), and life-satisfaction (LS). The data were analyzed using linear mixed modelling. Results We analyzed N = 491 participants (nIG = 244, nCG = 247), aged M = 76.78 years (SD = 6.35). For the composite endpoint, neither a significant difference between IG and CG (p = .88) nor a group-time interaction (p = .52; p = .88) could be observed. Participants in both groups showed a significant decline on the primary outcome between T0 and T2 (p
- Published
- 2023
- Full Text
- View/download PDF
5. Using the Metro-Map Metaphor for Drawing Hypergraphs.
- Author
-
Fabian Frank, Michael Kaufmann 0001, Stephen G. Kobourov, Tamara Mchedlidze, Sergey Pupyrev, Torsten Ueckerdt, and Alexander Wolff 0001
- Published
- 2021
- Full Text
- View/download PDF
6. Computing β-Stretch Paths in Drawings of Graphs.
- Author
-
Esther M. Arkin, Faryad Darabi Sahneh, Alon Efrat, Fabian Frank, Radoslav Fulek, Stephen G. Kobourov, and Joseph S. B. Mitchell
- Published
- 2020
- Full Text
- View/download PDF
7. Novel fibrin-fibronectin matrix accelerates mice skin wound healing
- Author
-
Jara, Carlos Poblete, Wang, Ou, Paulino do Prado, Thais, Ismail, Ayman, Fabian, Frank Marco, Li, Han, Velloso, Licio A., Carlson, Mark A., Burgess, William, Lei, Yuguo, Velander, William H., and Araújo, Eliana P.
- Published
- 2020
- Full Text
- View/download PDF
8. Reversible associations between human plasma fibronectin and fibrinogen γγ’ heterodimer observed by high pressure size exclusion chromatography and dynamic light scattering
- Author
-
Fabian, Frank M., Ismail, Ayman E.A., Wang, Ou, Lei, Yuguo, and Velander, William H.
- Published
- 2020
- Full Text
- View/download PDF
9. The CopA2-Type P1B-Type ATPase CcoI Serves as Central Hub for cbb3-Type Cytochrome Oxidase Biogenesis
- Author
-
Andreea Andrei, Maria Agostina Di Renzo, Yavuz Öztürk, Alexandra Meisner, Noel Daum, Fabian Frank, Juna Rauch, Fevzi Daldal, Susana L. A. Andrade, and Hans-Georg Koch
- Subjects
P1B-type ATPases ,CcoI ,cbb3-type cytochrome c oxidase biogenesis ,SenC ,Rhodobacter capsulatus ,solid-supported membrane electrophysiology ,Microbiology ,QR1-502 - Abstract
Copper (Cu)-transporting P1B-type ATPases are ubiquitous metal transporters and crucial for maintaining Cu homeostasis in all domains of life. In bacteria, the P1B-type ATPase CopA is required for Cu-detoxification and exports excess Cu(I) in an ATP-dependent reaction from the cytosol into the periplasm. CopA is a member of the CopA1-type ATPase family and has been biochemically and structurally characterized in detail. In contrast, less is known about members of the CopA2-type ATPase family, which are predicted to transport Cu(I) into the periplasm for cuproprotein maturation. One example is CcoI, which is required for the maturation of cbb3-type cytochrome oxidase (cbb3-Cox) in different species. Here, we reconstituted purified CcoI of Rhodobacter capsulatus into liposomes and determined Cu transport using solid-supported membrane electrophysiology. The data demonstrate ATP-dependent Cu(I) translocation by CcoI, while no transport is observed in the presence of a non-hydrolysable ATP analog. CcoI contains two cytosolically exposed N-terminal metal binding sites (N-MBSs), which are both important, but not essential for Cu delivery to cbb3-Cox. CcoI and cbb3-Cox activity assays in the presence of different Cu concentrations suggest that the glutaredoxin-like N-MBS1 is primarily involved in regulating the ATPase activity of CcoI, while the CopZ-like N-MBS2 is involved in Cu(I) acquisition. The interaction of CcoI with periplasmic Cu chaperones was analyzed by genetically fusing CcoI to the chaperone SenC. The CcoI-SenC fusion protein was fully functional in vivo and sufficient to provide Cu for cbb3-Cox maturation. In summary, our data demonstrate that CcoI provides the link between the cytosolic and periplasmic Cu chaperone networks during cbb3-Cox assembly.
- Published
- 2021
- Full Text
- View/download PDF
10. Metal‐Free B‐B Dehydrocoupling Reaction of a Simple Borane Adduct: Convenient Access to a Nucleophilic Diborane(4)
- Author
-
Kistner, Lucas, primary, Sigmund, Lukas Maximilian, additional, Grieser, Fabian Frank, additional, Krauß, Julian, additional, Leingang, Simone, additional, Kaifer, Elisabeth, additional, Greb, Lutz, additional, and Himmel, Hans-Jörg, additional
- Published
- 2023
- Full Text
- View/download PDF
11. Prevalence, symptomatology, risk factors and healthcare services utilization regarding paternal depression in Germany: study protocol of a controlled cross-sectional epidemiological study
- Author
-
Julia Albicker, Lars P. Hölzel, Jürgen Bengel, Katharina Domschke, Levente Kriston, Miriam A. Schiele, and Fabian Frank
- Subjects
Depression ,Depressive symptoms ,Postpartum ,Father ,Men ,Epidemiological study ,Psychiatry ,RC435-571 - Abstract
Abstract Background While postpartum depression is a well-researched disorder in mothers, there is growing evidence indicating that some fathers also develop depressive symptoms (paternal postpartum depression, PPD). A recent meta-analysis revealed a total prevalence of paternal depression during pregnancy and up to one year postpartum of 8.4%, with significant heterogeneity observed among prevalence rates. International studies suggest that PPD is characterized by additional symptoms compared to maternal postpartum depression. Furthermore, various risk factors of PPD have been identified. However, the prevalence, symptomatology, risk factors and healthcare situation of fathers affected by PPD in Germany are unknown. Methods/design This study comprises a controlled, cross-sectional epidemiological survey administered via postal questionnaires. The primary objective is to compare the prevalence of depressive symptoms in fathers with a 0–12-month-old infant to the prevalence of depressive symptoms in men without recent paternity. Two structurally differing regions (concerning birthrate, employment status, socioeconomic structure, and nationality of inhabitants) will be included. A random sample of 4600 fathers (2300 in each region) in the postpartum period and 4600 men without recent paternity matched by age, nationality and marital status will be assessed regarding depressive symptoms using the PHQ-9. Contact data will be extracted from residents’ registration offices. As secondary objectives, the study aims to provide insights into symptoms and risk factors of PPD in fathers and to assess the current healthcare situation of fathers with PPD in Germany. In an add-on study, genetic and epigenetic mechanisms of PPD will be explored. Discussion This study will conduct the first direct comparison between fathers in the postpartum period of one year after childbirth and a matched sample of men without a newborn child. Besides closing this research gap, the findings will provide prevalence estimates as well as insights into specific symptomatology, risk factors, and the current healthcare situation regarding fathers with PPD in Germany. The results will identify low-threshold approaches as a relevant issue for healthcare. Moreover, the findings should inform the development of PPD-specific screening instruments and healthcare offers addressing fathers with PPD. Trial registration German Clinical Trials Register (DRKS): DRKS00013339; Trial registration date: August 20, 2018; Universal Trial Number (UTN): U1111–1218-8185.
- Published
- 2019
- Full Text
- View/download PDF
12. Local, collaborative, stepped and personalised care management for older people with chronic diseases (LoChro): study protocol of a randomised comparative effectiveness trial
- Author
-
Fabian Frank, Frederike Bjerregaard, Jürgen Bengel, Eva Maria Bitzer, Bernhard Heimbach, Klaus Kaier, Jasmin Kiekert, Lena Krämer, Cornelia Kricheldorff, Katharina Laubner, Andy Maun, Gloria Metzner, Wilhelm Niebling, Claudia Salm, Sandra Schütter, Jochen Seufert, Erik Farin, and Sebastian Voigt-Radloff
- Subjects
Collaborative care ,Elderly ,Chronic disease ,Multimorbidity ,Depression ,Diabetes ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background Multimorbid older adults suffering from a long-term health condition like depression, diabetes mellitus type 2, dementia or frailty are at high risk of losing their autonomy. Disability and multimorbidity in the older population are associated with social inequality and lead to soaring costs. Our local, collaborative, stepped and personalised care management for older people with chronic diseases (LoChro-Care) aims at improving outcomes for older multimorbid patients with chronic conditions whose social and medical care must be improved. Methods The study will evaluate the effects of LoChro-Care on functional health, depressive symptoms and satisfaction with care, resource utilisation as well as health costs in older persons with long-term conditions. The trial will compare the effectiveness of LoChro-Care and usual care in a cross-sectoral setting from hospital to community care. We will recruit 606 older adults (65+) admitted to local hospital inpatient or outpatient departments who are at risk of loss of independence. Half of them will be randomised to receive the LoChro-Care intervention, comprising seven to 16 contacts with chronic care managers (CCM) within 12 months. The hypothesis that LoChro-Care will result in better patient-centred outcomes will be tested through mixed-method process and outcome evaluation and valid measures completed at baseline and at 12 and 18 months. Cost-effectiveness analyses from the healthcare perspective will include incremental cost-effectiveness ratios. Discussion The trial will provide evidence about the effectiveness of local, collaborative, stepped and personalised care management for multimorbid patients with more than one functional impairment or chronic condition. Positive results will be a first step towards the implementation of a systematic cross-sectoral chronic care management to facilitate the appropriate use of available medical and nursing services and to enhance self-management of older people. Trial registration German Clinical Trials Register (DRKS): DRKS00013904; Trial registration date: 02. February 2018.
- Published
- 2019
- Full Text
- View/download PDF
13. The isolation of a plasma-derived γγ’ fibrinogen: Fibronectin mixture that forms a novel polymeric matrix
- Author
-
Ismail, Ayman E.A., Fabian, Frank M., Wang, Ou, Lei, Yuguo, Carlson, Mark A., Burgess, Wilson H., and Velander, William H.
- Published
- 2018
- Full Text
- View/download PDF
14. Education and employment status of adults with autism spectrum disorders in Germany – a cross-sectional-survey
- Author
-
Fabian Frank, Martina Jablotschkin, Tobias Arthen, Andreas Riedel, Thomas Fangmeier, Lars P. Hölzel, and Ludger Tebartz van Elst
- Subjects
Autism ,Asperger syndrome ,High functioning ,Employment ,Education ,Adults ,Psychiatry ,RC435-571 - Abstract
Abstract Background Adults with autism spectrum disorders (ASD) experience challenges in participating in the labour market and struggle to achieve and maintain appropriate professional positions, possibly due to impairments of communication and social interaction. Studies have shown high rates of unemployment as well as evidence of inadequate employment. As knowledge on the participation in the German labour market is scarce, the aim of our study was to examine employment status, type of occupation and inadequate employment in a sample of clinically mostly late-diagnosed and most likely not intellectually disabled adults with ASD in Germany. Methods We conducted a cross-sectional-survey in clinically mostly late-diagnosed adults with ASD. Employment status, type of occupation, and the level of formal education and training were examined through a postal questionnaire. Inadequate employment regarding participants’ current and longest practised occupation was assessed by transforming participants’ information into skill levels of the “Classification of Occupations 2010” of the German Federal Employment Agency, and comparing these with participants’ level of formal education and training. Results The response rate was 43.2% (N = 185 of N = 428 potential participants). 94.6% were first-time diagnosed when being 18 years of age or older. 56.8% held a general university entrance-level qualification and 24.9% had obtained a Masters’ or diploma degree as their highest vocational qualification. 94.1% had been employed at some time. Of these, 68.4% reported being currently employed, 13.5% being currently unemployed and 17.0% being retired for health reasons. Regarding the longest-practised and the current occupation, the highest proportion of participants was found in the occupational area “health and social sector, teaching and education” (22.4% and 23.3%, respectively). With respect to inadequate employment, 22.1% were found to be overeducated in relation to their longest-practised occupation and 31.3% in relation to their current occupation. This is significantly higher than the percentage of overeducation in the general population. Conclusions Despite largely high formal qualifications, the clinically mostly late-diagnosed adults with ASD represented in our sample are disadvantaged regarding their participation in the German labour market, especially with respect to rates of unemployment, early retirement and overeducation. Employment support programs should be developed to improve employment outcomes.
- Published
- 2018
- Full Text
- View/download PDF
15. Signaling ammonium across membranes through an ammonium sensor histidine kinase
- Author
-
Tobias Pflüger, Camila F. Hernández, Philipp Lewe, Fabian Frank, Haydyn Mertens, Dmitri Svergun, Manfred W. Baumstark, Vladimir Y. Lunin, Mike S. M. Jetten, and Susana L. A. Andrade
- Subjects
Science - Abstract
For anammox bacteria, the sensing and uptake of ammonium is essential and specialized proteins, like Ks-Amt5, mediate such processes. Here, authors perform biophysical, biochemical, and structural analysis on Ks-Amt5 and establish a role for this protein as an ammonium-sensing signal transducer.
- Published
- 2018
- Full Text
- View/download PDF
16. Prüfstand für Wasserstoffantriebe mit simulationsgestütztem Sicherheitskonzept
- Author
-
Florian Sobek, Fabian Frank, Theo Gottwald, and Sebastian Dressel
- Subjects
General Medicine - Published
- 2022
- Full Text
- View/download PDF
17. Metal‐Free B−B Dehydrocoupling Reaction of a Simple Borane Adduct: Convenient Access to a Nucleophilic Diborane(4).
- Author
-
Kistner, Lucas, Sigmund, Lukas Maximilian, Grieser, Fabian Frank, Krauß, Julian, Leingang, Simone, Kaifer, Elisabeth, Greb, Lutz, and Himmel, Hans‐Jörg
- Subjects
BORANES ,DIBORANE ,HYDRIDES - Abstract
The selective formation of homonuclear bonds is of key importance in synthetic chemistry. Especially, dehydrocoupling reactions are attractive as ecologically and economically friendly alternatives to established reductive bond forming reactions, since they do not require the use of stoichiometric amounts of a reducing reagent and produce only valuable dihydrogen as by‐product. Here, we report on a metal‐free B−B dehydrocoupling reaction that starts directly from a simple, easily accessible BH3 adduct, providing convenient access to a new nucleophilic dihydridodiborane in excellent yield. The dihydridodiborane in turn activates dihydrogen, allowing to obtain quantitatively the dideuteridodiborane from the dihydridodiborane by D2 activation. On the basis of detailed quantum‐chemical calculations, the mechanism of this unprecedented reaction is elucidated. Some key points that are essential for metal‐free dehydrocoupling are disclosed, paving the way for their systematic evaluation and application. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
18. Metallfreie B−B Dehydrokupplung eines Einfachen Boran‐Addukts: Bequemer Zugang zu einem Nukleophilen Diboran(4).
- Author
-
Kistner, Lucas, Sigmund, Lukas Maximilian, Grieser, Fabian Frank, Krauß, Julian, Leingang, Simone, Kaifer, Elisabeth, Greb, Lutz, and Himmel, Hans‐Jörg
- Abstract
Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
19. Social Support Networks of Individuals with Depressive Disorders: A Cross-sectional Survey in Former Psychiatric Inpatients in Germany
- Author
-
Heiko Löwenstein and Fabian Frank
- Subjects
Health (social science) ,Public Health, Environmental and Occupational Health - Abstract
Depressive disorders are related to social withdrawal and a loss of social contacts. Moreover, a lack of social integration and social support are risk factors for relapse and rehospitalization. Despite the crucial role of social networks for mental health and social support, knowledge about the structure of social networks or how they promote social support in terms of coping with depressive disorders is scarce. The present study aims to analyze social support in people with depressive disorders using ego-centered social network analysis for formal description. Ninety-seven former psychiatric inpatients participated in the study. Network size and density, a small number of conflicts in the relationships of ego to alters, and the multiplexity of social support dimensions were associated with perceived social support—measured via Social Support Questionnaire (F-Soz-U-K-14). Considering relational ratios which correlated with perceived social support, five types of social support networks were differentiated by means of cluster analysis: (1) no social support, (2) professionally supported birth family, (3) the more the merrier, (4) concentrated support, (5) overchallenged nuclear family. More than each relational characteristic on its own, their co-occurring patterns as network types provide the very structures of social support. This underpins the crucial role of structural approaches and networking skills in social work practice. German Clinical Trials Register (DRKS): DRKS00011561. Trial registration date: 10. March 2017.
- Published
- 2022
- Full Text
- View/download PDF
20. Bench-scale fuel fire test for materials of rechargeable energy storage system housings
- Author
-
Carl-Christoph Höhne, Volker Gettwert, Fabian Frank, Sascha Kilian, Andreas Menrath, and Publica
- Subjects
Flame, fire & explosion testing ,DDC::500 Naturwissenschaften und Mathematik ,Electric mobility ,Thermoplastic sandwich structures ,Physical and Theoretical Chemistry ,REESS ,Condensed Matter Physics ,Bench-scale fuel fire test ,Flame resistance ,Fibre-reinforced thermosets ,Flame retardant - Abstract
The fire behaviour of electric vehicles (EVs) differs from that of vehicles with combustion engines. Especially the rechargeable energy storage system (REESS) requires special fire protection measures. The fire behaviour of materials for REESS housings plays an important role in the fire resistance of such systems. Full-scale fire resistance tests like gasoline pool fire tests on complete REESS according to the UNECE-R100-8E standard are mandatory for EVs. However, these tests are not applicable for materials used for REESS housings in the material and process development state, due to the high material demand and production costs of the REESS. Standard tests like the limiting oxygen index test, UL94-V test or cone calorimeter test are insufficient to analyse the fire behaviour of thermoplastic and thermoset materials in a gasoline pool fire. This paper describes a bench-scale fuel fire test including several test criteria to evaluate materials for REESS housings on a laboratory scale. This bench-scale fire test is demonstrated on two case studies: fibre-reinforced thermoset plates and thermoplastic sandwich structures.
- Published
- 2023
- Full Text
- View/download PDF
21. TrustedGateway: TEE-Assisted Routing and Firewall Enforcement Using ARM TrustZone
- Author
-
Fabian Frank Schwarz
- Published
- 2022
- Full Text
- View/download PDF
22. Mecanismos de seguridad en las estrategias de gestión documental en el proceso de envío y recepción de documentos oficiales
- Author
-
Oscar Alberto Gonzalez Gonzalez, Fabian Frank Hernandez, and Laura Beatriz Vidal Turrubiates
- Subjects
Government ,Information storage ,Political science ,Welfare economics ,State government ,Document management system ,computer.software_genre ,computer - Abstract
Hoy en dia la informacion que se maneja en las distintas dependencias de la Administracion Publica es susceptible de optimizacion que reduzca los riesgos de amenaza. El presente articulo describe los procesos de gestion documental usada en las dependencias del Gobierno del Estado de Tabasco y la necesidad de hacerlos mas eficientes. Se describe el modelo metodologico que se utiliza para la obtencion de los resultados, los cuales, en su seccion inmediata, se enlistan los mecanismos de seguridad recomendados ad hoc para la dependencia de gobierno estudiada, los cuales incluyen desde el almacenamiento de la informacion, hasta la transmision de la misma. Organizational communication trough documents between public administration offices, may be compromised in case of external or internal thread. This article presents advances of research on the processes of governmental document management applied at offices in Tabasco’s State Government. It also describes the methodology used, and the security strategies recommended ad hoc, including information storage and transmission. Nowadays, the information handled in the different agencies of the Public Administration is susceptible to optimization that reduces the risks of threat. This article describes the document management processes used in the agencies of the Government of the State of Tabasco and the need to make them more efficient. It describes the methodological model used to obtain the results, which, in its immediate section, lists the security mechanisms recommended ad hoc for the government agency studied, which include from the storage of information to its transmission. Organizational communication through documents between public administration offices, may be compromised in case of external or internal thread. This article presents advances of research on the processes of governmental document management applied at offices in Tabasco's State Government. It also describes the methodology used, and the security strategies recommended ad hoc, including information storage and transmission.
- Published
- 2021
- Full Text
- View/download PDF
23. Begleitung von Menschen mit ASS auf den ersten Arbeitsmarkt
- Author
-
Kerstin Arnold and Fabian Frank
- Published
- 2021
- Full Text
- View/download PDF
24. Flamm- und Brandschutz für die Elektromobilität
- Author
-
Carl-Christoph Höhne, Volker Gettwert, Andreas Menrath, Fabian Frank, Michael Abert, Johannes Liebertseder, and Publica
- Subjects
Flame, fire & explosion testing ,Brandschutz ,Batteriegehäuse ,Flammschutz ,Flame retardant - Abstract
Elektrofahrzeuge unterscheiden sich im Flamm- und Brandverhalten von Fahrzeugen mit Verbrennungsmotor. Insbesondere die Sicherheit der Traktionsbatterie stellt eine Herausforderung dar. Neben einer Beschädigung der Batteriezellen durch ein externes Schadereignis, beispielsweise ein Brand, verursacht durch einen Unfall mit einem kraftstoffbetriebenen Fahrzeug, kann die Batterie selbst durch internes Versagen zur Gefahrenquelle werden. Eine entsprechend wichtige Sicherheitsfunktion übernimmt daher das Batteriegehäuse. Um Gewicht und Kosten zu senken, werden Gehäuse aus faserverstärkten Kunststoffen entwickelt.
- Published
- 2022
25. Optimizing the detection, ablation, and ion extraction efficiency of a single-particle laser ablation mass spectrometer for application in environments with low aerosol particle concentrations
- Author
-
Fabian Frank, Frank Stratmann, Franziska Köllner, Heike Wex, Frank Helleis, Rebecca Kohl, Thomas Klimach, Johannes Schneider, Florian Rubach, Stephan Borrmann, André Welti, Stephan Mertes, Hans-Christian Clemen, and Andreas Hünig
- Subjects
Atmospheric Science ,Range (particle radiation) ,Laser ablation ,Materials science ,010504 meteorology & atmospheric sciences ,Particle number ,Spectrometer ,lcsh:TA715-787 ,lcsh:Earthwork. Foundations ,Analytical chemistry ,010501 environmental sciences ,01 natural sciences ,Charged particle ,lcsh:Environmental engineering ,Particle ,Particle size ,lcsh:TA170-171 ,Particle beam ,0105 earth and related environmental sciences - Abstract
The aim of this study is to show how a newly developed aerodynamic lens system (ALS), a delayed ion extraction (DIE), and better electric shielding improve the efficiency of the Aircraft-based Laser ABlation Aerosol MAss spectrometer (ALABAMA). These improvements are applicable to single-particle laser ablation mass spectrometers in general. To characterize the modifications, extensive size-resolved measurements with spherical polystyrene latex particles (PSL; 150–6000 nm) and cubic sodium chloride particles (NaCl; 400–1700 nm) were performed. Measurements at a fixed ALS position show an improved detectable particle size range of the new ALS compared to the previously used Liu-type ALS, especially for supermicron particles. At a lens pressure of 2.4 hPa, the new ALS achieves a PSL particle size range from 230 to 3240 nm with 50 % detection efficiency and between 350 and 2000 nm with 95 % detection efficiency. The particle beam divergence was determined by measuring the detection efficiency at variable ALS positions along the laser cross sections and found to be minimal for PSL at about 800 nm. Compared to measurements by single-particle mass spectrometry (SPMS) instruments using Liu-type ALSs, the minimum particle beam divergence is shifted towards larger particle sizes. However, there are no disadvantages compared to the Liu-type lenses for particle sizes down to 200 nm. Improvements achieved by using the DIE and an additional electric shielding could be evaluated by size-resolved measurements of the hit rate, which is the ratio of laser pulses yielding a detectable amount of ions to the total number of emitted laser pulses. In particular, the hit rate for multiply charged particles smaller than 500 nm is significantly improved by preventing an undesired deflection of these particles in the ion extraction field. Moreover, it was found that by using the DIE the ion yield of the ablation, ionization, and ion extraction process could be increased, resulting in up to 7 times higher signal intensities of the cation spectra. The enhanced ion yield results in a larger effective width of the ablation laser beam, which in turn leads to a hit rate of almost 100 % for PSL particles in the size range from 350 to 2000 nm. Regarding cubic NaCl particles the modifications of the ALABAMA result in an up to 2 times increased detection efficiency and an up to 5 times increased hit rate. The need for such instrument modifications arises in particular for measurements of particles that are present in low number concentrations such as ice-nucleating particles (INPs) in general, but also aerosol particles at high altitudes or in pristine environments. Especially for these low particle number concentrations, improved efficiencies help to overcome the statistical limitations of single-particle mass spectrometer measurements. As an example, laboratory INP measurements carried out in this study show that the application of the DIE alone increases the number of INP mass spectra per time unit by a factor of 2 to 3 for the sampled substances. Overall, the combination of instrument modifications presented here resulted in an increased measurement efficiency of the ALABAMA for different particle types and particles shape as well as for highly charged particles.
- Published
- 2020
26. Digitalization and simulation of hydrogen technologies
- Author
-
Sylvia Schattauer, Alexander Spieß, Alexander Martin, Robert Burlacu, Gregor Herz, Christian Leithäuser, Ulrike Beyer, Joachim Seidelmann, and Fabian Frank
- Published
- 2022
- Full Text
- View/download PDF
27. Digitalisierung und Simulation von Wasserstofftechnologien
- Author
-
Sylvia Schattauer, Alexander Spieß, Alexander Martin, Robert Burlacu, Gregor Herz, Christian Leithäuser, Ulrike Beyer, Joachim Seidelmann, and Fabian Frank
- Published
- 2022
- Full Text
- View/download PDF
28. The Size Distribution of Cellulose Nanocrystals in the Variation of Acid-to-Microcellulose Crystals Ratio and Reaction Time Through Catalyzed Acid Hydrolysis
- Author
-
YANG, YUCHENG, primary, Ma, Qin, primary, Hyblova, Kristyna, primary, Fabian, Frank, primary, and Mckenize, Janice, primary
- Published
- 2021
- Full Text
- View/download PDF
29. Using the Metro-Map Metaphor for Drawing Hypergraphs
- Author
-
Tamara Mchedlidze, Stephen G. Kobourov, Torsten Ueckerdt, Alexander Wolff, Sergey Pupyrev, Fabian Frank, and Michael Kaufmann
- Subjects
Vertex (graph theory) ,Planar embedding ,Metaphor ,media_common.quotation_subject ,Computer Science::Software Engineering ,Edge (geometry) ,Planar graph ,Set (abstract data type) ,Combinatorics ,symbols.namesake ,Simple (abstract algebra) ,Computer Science::Networking and Internet Architecture ,symbols ,Embedding ,Mathematics ,media_common - Abstract
For a planar graph G and a set \(\varPi \) of simple paths in G, we define a metro-map embedding to be a planar embedding of G and an ordering of the paths of \(\varPi \) along each edge of G. This definition of a metro-map embedding is motivated by visual representations of hypergraphs using the metro-map metaphor. In a metro-map embedding, two paths cross in a so-called vertex crossing if they pass through the vertex and alternate in the circular ordering around it.
- Published
- 2021
- Full Text
- View/download PDF
30. Differences in and Prognostic Value of Quality of Life Data in Rectal Cancer Patients with and without Distant Metastases
- Author
-
Fabian Frank, Markus Hecht, Florian Loy, Sandra Rutzner, Rainer Fietkau, and Luitpold Distel
- Subjects
lcsh:R ,health related quality of life ,lcsh:Medicine ,colorectal cancer ,ddc:610 ,patient reported outcomes ,prognostication ,metastatic disease ,Article ,humanities - Abstract
(1) Background: Individualization of treatment is a major challenge in oncology and requires a variety of predictive and prognostic parameters. In addition to tumor biology analyses, baseline health-related quality of life might be a valid tool to predict overall survival. This study was conducted to evaluate the prognostic relevance of baseline quality of life data in patients with rectal cancer. In this context, differences between patients with and without distant metastases were of particular interest. (2) Methods: Our cohort included 258 patients with rectal cancer treated in the radiotherapy department of the University Hospital Erlangen. Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (QLQ C30) and colorectal cancer questionnaire (CR38). Clinical and survival data were provided by the Gieß, ener Tumor Documentation System (GTDS) of the Comprehensive Cancer Center Erlangen-EMN (CCC, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany). Statistical analyses were performed using Kaplan&ndash, Meier analyses and univariate and multivariate Cox regression. (3) Results: A cohort of 258 patients with rectal adenocarcinoma was analyzed including 50 patients (19.4%) with metastatic disease. No differences were observed between patients with and without distant metastases in most areas of quality of life studied, with the exception of physical function, loss of appetite, chemotherapy side effects and weight loss. Gender, baseline physical function, sexual function, diarrhea, and weight loss over time had a prognostic value in the entire cohort. Appetite loss was an additional prognostic parameter in patients with distant metastases. (4) Conclusions: The quality of life of patients with metastatic disease differed only slightly from non-metastatic patients. Health-related quality of life data provide prognostic information for patients with rectal cancer.
- Published
- 2020
31. Supplementary material to 'Optimizing the detection, ablation and ion extraction efficiency of a single particle laser ablation mass spectrometer for application in environments with low aerosol particle concentrations'
- Author
-
Hans-Christian Clemen, Johannes Schneider, Thomas Klimach, Frank Helleis, Franziska Köllner, Andreas Hünig, Florian Rubach, Stephan Mertes, Heike Wex, Frank Stratmann, André Welti, Rebecca Kohl, Fabian Frank, and Stephan Borrmann
- Published
- 2020
- Full Text
- View/download PDF
32. Optimizing the detection, ablation and ion extraction efficiency of a single particle laser ablation mass spectrometer for application in environments with low aerosol particle concentrations
- Author
-
Hans-Christian Clemen, Johannes Schneider, Thomas Klimach, Frank Helleis, Franziska Köllner, Andreas Hünig, Florian Rubach, Stephan Mertes, Heike Wex, Frank Stratmann, André Welti, Rebecca Kohl, Fabian Frank, and Stephan Borrmann
- Abstract
The aim of this study is to show how a newly developed aerodynamic lens system (ALS), a delayed ion extraction (DIE) and better electric shielding improve the efficiency of the Aircraft-based Laser ABlation Aerosol MAss spectrometer (ALABAMA). These improvements are applicable to single particle laser ablation mass spectrometers in general. To characterize the modifications extensive size-resolved measurements with spherical polystyrene latex particles (PSL; 150–000 nm) and cubic sodium chloride particles (NaCl; 400–1700 nm) were performed. Measurements at a fixed ALS position show an improved detectable particle size range of the new ALS compared to the previously used Liu-type ALS, especially for super-micron particles. At a lens pressure of 2.4 hPa, the new ALS achieves a PSL particle size range from 230 nm to 3240 nm with 50 % detection efficiency and between 350 nm and 2000 nm with 95 % detection efficiency. The particle beam divergence was determined by measuring the detection efficiency at variable ALS positions along the laser cross sections and found to be minimal for PSL at about 800 nm. Compared to measurements of SPMS instruments using Liu-type ALSs, the minimum particle beam divergence is shifted towards larger particle sizes. However, there are no disadvantages compared to the Liu-type lenses for particle sizes down to 200 nm. Improvements achieved by using the DIE and an additional electric shielding could be evaluated by size-resolved measurements of the hit rate, which is the ratio of laser pulses yielding a detectable amount of ions to the total number of emitted laser pulses. In particular, the hit rate for multiply charged particles smaller 500 nm is significantly improved by preventing an undesired deflection of these particles in the ion extraction field. Moreover, it was found that by using the DIE the ion yield of the ablation, ionization and ion extraction process could be increased, resulting in up to seven times higher signal intensities of the cation spectra. The enhanced ion yield results in a larger effective width of the ablation laser beam, which in turn leads to a hit rate of almost 100 % for PSL particles in the size range from 350 nm to 2000 nm. Regarding cubic NaCl particles the modifications of the ALABMA result in a up to two times increased detection efficiency and a up to five times increased hit rate. The need for such instrument modifications arises in particular for measurements of particles that are present in low number concentrations such as ice nucleation particles (INP) in general, but also aerosol particles at high altitudes or in pristine environments. Especially for these low particle number concentrations improved efficiencies help to overcome statistical limitations of single particle mass spectrometer measurements. As an example laboratory INP measurements carried out in this study show that the application of the DIE alone increases the number of INP mass spectra per time unit by a factor of two to three for the sampled substances. Overall, the combination of instrument modifications presented here resulted in an increased measurement efficiency of the ALABAMA for different particle types, particles shapes and for highly charged particles.
- Published
- 2020
33. A decision-theoretic approach to sustain public protection under climate change based on ensembles of future hazard developments
- Author
-
Katharina Enigl, Christoph Matulla, Fabian Frank, Matthias Schlögl, Franz Schmid, and Ingo Schnetzer
- Abstract
In large parts of the world, an increasing number of damaging events caused by previously rare extreme weather phenomena is being observed. This poses a challenge to those responsible for civil protection of how to sustain current safety levels under accelerated climate change. The aim of this study is to contribute to meeting these challenges by providing methods to determine anticipatory strategies for decades of sustainable protection. This endeavor requires the identification of weather-related hazard processeson on the one, and the establishment of corresponding future hazard development corridors on the other hand. The former, so-called Climate Indices (CIs), are determined by blending damage events and spatiotemporal highly resolved meteorological data for three different regions in the Austrian Alpine region and six different process categories via multivariate statistical analyses. The derivation of hazard development corridors describing future changes in risk landscapes requires ensembles of regional climate projections, in which the occurrence of corresponding CIs is detected.Results are incorporated into the decision-making process and processed together with experts in civil protection. The determination of optimal, sustainable protection strategies is based on decision-theoretical techniques and the application of the expected utility theory (Bernoulli principle).The feasibility of integrating hazard development corridors into decision-making processes, as well as the satisfactory implementation of established procedures, is demonstrated by the most comprehensive civil protection project in Austria to date. The results are consistent and show significant differences between near (2036-2065) and far future (2071-2100) time periods, as well as between the threat levels corresponding to the "climate-friendly" path of humanity and those associated with the "business as usual" scenario. The results are in line with the European Floods Directive by ranking linear measures behind resettlement and retention measures.
- Published
- 2020
- Full Text
- View/download PDF
34. Implementierbarkeit des GermanIMPACT Collaborative Care Programms zur Unterstützung der hausärztlichen Versorgung älterer depressiver Menschen - eine qualitative Interviewstudie
- Author
-
Lars P. Hölzel, Julia Zech, Fabian Frank, Frederike Bjerregaard, Rolf-Dieter Stieglitz, and Michael Hüll
- Subjects
Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Health Policy ,medicine ,Primary health care ,Medicine (miscellaneous) ,030212 general & internal medicine ,business ,030217 neurology & neurosurgery ,Education - Abstract
Zusammenfassung Hintergrund Collaborative-Care-Modelle wie das Improving Mood Promoting Access to Collaborative Care Programm (IMPACT) sind eine Moglichkeit, um die hausarztliche Versorgung von alteren depressiven Patienten zu unterstutzen. In der GermanIMPACT Studie wird untersucht, ob dieses niederschwellige Modell mit kurzen verhaltenstherapeutischen Interventionen, die von Therapiebegleiterinnen durchgefuhrt und von einer Psychotherapeutin/Psychiaterin supervidiert werden, ebenso wirksam ist, wie in anderen Landern bereits nachgewiesen. Fur die Implementierbarkeit des Programmes ist neben der Wirksamkeit auch die Durchfuhrbarkeit der Intervention essentiell. Methode In leitfadengestutzten qualitativen Interviews wurden die Therapiebegleiterinnen und Supervisorinnen zu ihrer Einschatzung der Durchfuhrbarkeit und Wirksamkeit der GermanIMPACT Intervention befragt und die Interviews mittels eines qualitativ-inhaltsanalytischen Analysemodelles ausgewertet. Ergebnisse Die Befragten gaben wichtige Hinweise zur Optimierung der Interventionsumsetzung. Unter anderem wurden eine kritischere Auswahl der Patienten und mehr Schulung der Therapiebegleiterinnen genannt. Gleichzeitig wurde die Intervention als unterstutzend fur Patienten und als entlastend fur Hausarzte bezeichnet. Wahrend sich die Befragten eine Ausweitung der Intervention auch auf andere Storungsbilder wunschen wurden, wurden auch gleichzeitig Grenzen der Intervention aufgezeigt. Diskussion Die vorliegende Studie liefert praktische Hinweise fur die Implementierbarkeit des GermanIMPACT Modells, aus denen sich konkrete Handlungsanweisungen fur die Umsetzung in die Regelversorgung ableiten lassen.
- Published
- 2018
- Full Text
- View/download PDF
35. Angehörigenpsychoedukation bei Depression : Ein Manual
- Author
-
Lars P. Hölzel, Fabian Frank, Lars P. Hölzel, and Fabian Frank
- Subjects
- Families--Mental health, Depression, Mental
- Abstract
Wenn ein Mensch an einer Depression erkrankt, kann dies auch starke Auswirkungen auf sein soziales Umfeld haben. Je näher die Beziehungen, desto stärker sind häufig die Veränderungen. Diese Veränderungen können Beziehungen nachhaltig beeinträchtigen. Gleichzeitig wirkt sich die Qualität der zwischenmenschlichen Beziehungen auch auf den Krankheitsverlauf aus. Angehörige spielen daher bei der Versorgung von an Depression erkrankten Menschen eine wichtige Rolle. Das vorliegende Buch beschreibt eine Gruppenintervention, die über einen einfachen Einbezug von Angehörigen hinausgeht und Angehörigen die wesentlichen Informationen über depressive Erkrankungen sowie das Handwerkszeug für einen konstruktiven Umgang mit problematischen Situationen vermittelt. Alle für die Intervention notwendigen Materialien werden als Online-Zusatzmaterial bereitgestellt.
- Published
- 2022
36. Praxisfall der Übertragung eines Einzelunternehmens : Zivilrechtliche, gesellschaftsrechtliche, steuerrechtliche Behandlung in der Erbschaft-, Einkommen- und Gewerbesteuer
- Author
-
Fabian Frank and Fabian Frank
- Abstract
Bachelorarbeit aus dem Jahr 2018 im Fachbereich BWL - Rechnungswesen, Bilanzierung, Steuern, Note: 1,0, Fachhochschule Worms, Sprache: Deutsch, Abstract: Die folgende Ausarbeitung beschäftigt sich mit einem Praxisfall der Übertragung eines Einzelunternehmens, seiner Behandlung zivilrechtlich, gesellschaftsrechtlich, steuerrechtlich in der Erbschaft-, Einkommen- und Gewerbesteuer. Abschließend liegt ein besonderer Fokus auf der Ermittlung der Erbschaftsteuer (insbesondere auf der Ermittlung des begünstigten Vermögens) und der Darstellung dieser in DATEV. Der Tod wird von den meisten Menschen verdrängt, man will es nicht wahrhaben, dass das Erdendasein endlich ist. In Bezug auf Steuern ist es von höchster Wichtigkeit sich frühzeitig über die Vererbung von Besitztümern und deren Gestaltungsmöglichkeiten z.B. von Betrieben oder Betriebsteilen Gedanken zu machen. Wird dies nicht frühzeitig geplant, kann es sehr teuer in der Erbschaftsteuer für den Erwerber werden. Oft ahnt der zukünftige Erblasser nicht, was seine Besitztümer an Steuerbelastung beim Erwerber auslösen, dementsprechend werden keine Regelungen getroffen. Ein Erblasser welcher in seiner Übertragungsmasse beispielsweise ein Einzelunternehmen vererbt sollte sich über die Vielzahl von bewertungstechnischen Umständen die es zu beachten gilt und welche mehrmals bei den Erbschaftsteuerreformen geändert wurden, einen Überblick verschaffen. Die Regelung des begünstigten Vermögens z.B. wurde letztmalig bei der Erbschaftsteuerreform v. 30.09.2016, mit Wirkung ab dem 01.07.2016 geändert, zu welcher das BV dieses Einzelunternehmens zählen würde.
- Published
- 2022
37. The Size Distribution of Cellulose Nanocrystals in the Variation of Acid-to-Microcellulose Crystals Ratio and Reaction Time Through Catalyzed Acid Hydrolysis
- Author
-
Yang, Yucheng, additional, Fabian, Frank, additional, McKenzie, Janice, additional, Hyblova, Kristyna, additional, and Ma, Qin, additional
- Published
- 2020
- Full Text
- View/download PDF
38. Three-Dimensional (3D) Fibronectin Nano-Array Presented on Fibrin Matrix Accelerates Mice Skin Wound Healing
- Author
-
Jara, Carlos Poblete, primary, Wang, Ou, additional, do Prado, Thais Paulino, additional, Ismail, Ayman, additional, Fabian, Frank Marco, additional, Li, Han, additional, Velloso, Licio A., additional, Carlson, Mark A., additional, Burgess, William, additional, Lei, Yuguo, additional, Velander, William H., additional, and Araújo, Eliana P., additional
- Published
- 2020
- Full Text
- View/download PDF
39. Bereitschaft zur Inanspruchnahme internetbasierter Unterstützung nach stationärer Behandlung – eine Querschnittstudie
- Author
-
Lars P. Hölzel, Mathias Berger, Fabian Frank, Nicola Gräder, and Hannah Dahlmann
- Subjects
Gynecology ,03 medical and health sciences ,Psychiatry and Mental health ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,05 social sciences ,medicine ,0501 psychology and cognitive sciences ,050108 psychoanalysis ,business ,030217 neurology & neurosurgery - Abstract
Zusammenfassung Ziele Untersuchung der Bereitschaft zur Inanspruchnahme internetbasierter Maßnahmen nach stationärer Behandlung. Methodik Querschnittbefragung an ehemals stationären Patienten (N = 247). Ergebnisse 44,9 % sind bereit, ein Angebot über Videokonferenz zu nutzen, 34,7 % über Chat, 50,0 % über Mail und 38,0 % als Onlinetherapie. In älteren Altersgruppen ist die Bereitschaft geringer. Vorteile werden in der Flexibilität und Nachteile im unpersönlichen Charakter gesehen. Schlussfolgerungen Ein relevanter Anteil vor allem jüngerer Patienten ist bereit, internetbasierte Maßnahmen in Anspruch zu nehmen.
- Published
- 2017
- Full Text
- View/download PDF
40. Videokonferenzbasierte psychotherapeutische Anschlussbehandlung
- Author
-
Nicole Ower, Nicola Gräder, Jeanette Röhrig, Mathias Berger, Julia Zech, Fabian Frank, and Lars P. Hölzel
- Subjects
03 medical and health sciences ,Clinical Psychology ,0302 clinical medicine ,030217 neurology & neurosurgery ,030227 psychiatry - Abstract
Hintergrund Die storungsspezifische psychotherapeutische Weiterbehandlung nach stationarer Entlassung ist aufgrund langer Wartezeiten und Versorgungsdisparitaten insbesondere in landlichen Regionen erschwert. Da eine fast flachendeckende Internetabdeckung in Deutschland gegeben ist, konnten psychotherapeutische Konzepte nach stationarer Entlassung uber Videokonferenzen fortgefuhrt werden, um die Behandlungskontinuitat zu ermoglichen. Das Kompetenzzentrum Psychotherapie an den Medizinischen Fakultaten Baden-Wurttemberg verfugt uber die Infrastruktur, videokonferenzbasierte Masnahmen nach aktuellen Datenschutzbestimmungen umzusetzen.
- Published
- 2017
- Full Text
- View/download PDF
41. ML-CIRRUS: The Airborne Experiment on Natural Cirrus and Contrail Cirrus with the High-Altitude Long-Range Research Aircraft HALO
- Author
-
Nicole Spelten, Romy Schlage, Johannes Schneider, Diana Rose, Paul Stock, Daniel Fütterer, Linda Forster, Fabian Frank, Heini Wernli, Ralf Weigel, Marcus Klingebiel, Frank Werner, Armin Afchine, Bernd Heinold, Bernadett Weinzierl, Andreas Minikin, Thomas Klimach, Helmut Ziereis, Maxi Boettcher, Andreas Zahn, Manfred Wendisch, Trismono Candra Krisna, Philipp Reutter, Ahmed Abdelmonem, Adrian Walser, Katharina Heimerl, Mareike Kenntner, Markus Rapp, Stephan Borrmann, Martin Schnaiter, Ulrich Schumann, Bernhard Mayer, Stephan Mertes, Luca Bugliaro, Andreas Petzold, Anna Luebke, Andreas Schäfler, Jens-Uwe Grooß, Stefan H. E. Kaufmann, Martin Wirth, Tilman Hüneke, Tina Jurkat, Sergej Molleker, Rebecca Kohl, Volker Ebert, Martin Zöger, Klaus Pfeilsticker, Max Port, Emma Järvinen, Joachim Curtius, Andreas Giez, Bernhard Buchholz, Maximilian Dollner, V. Dreiling, André Ehrlich, Andreas Dörnbrack, Christian Rolf, Silke Groß, Daniel Sauer, Andreas Fix, Peter Spichtinger, Martina Krämer, Kaspar Graf, Christiane Voigt, and Anja Costa
- Subjects
Atmospheric Science ,010504 meteorology & atmospheric sciences ,Meteorology ,satellite ,contrail cirrus ,cirrus ,010501 environmental sciences ,01 natural sciences ,modelling ,ML-CIRRUS ,Range (aeronautics) ,ddc:550 ,Wolkenphysik ,0105 earth and related environmental sciences ,Lidar ,Fernerkundung der Atmosphäre ,Verkehrsmeteorologie ,Atmosphärische Spurenstoffe ,Trace gas ,Aerosol ,Middle latitudes ,HALO ,Environmental science ,Cirrus ,Satellite ,Halo ,aircraft measurements - Abstract
The Midlatitude Cirrus experiment (ML-CIRRUS) deployed the High Altitude and Long Range Research Aircraft (HALO) to obtain new insights into nucleation, life cycle, and climate impact of natural cirrus and aircraft-induced contrail cirrus. Direct observations of cirrus properties and their variability are still incomplete, currently limiting our understanding of the clouds’ impact on climate. Also, dynamical effects on clouds and feedbacks are not adequately represented in today’s weather prediction models. Here, we present the rationale, objectives, and selected scientific highlights of ML-CIRRUS using the G-550 aircraft of the German atmospheric science community. The first combined in situ–remote sensing cloud mission with HALO united state-of-the-art cloud probes, a lidar and novel ice residual, aerosol, trace gas, and radiation instrumentation. The aircraft observations were accompanied by remote sensing from satellite and ground and by numerical simulations. In spring 2014, HALO performed 16 flights above Europe with a focus on anthropogenic contrail cirrus and midlatitude cirrus induced by frontal systems including warm conveyor belts and other dynamical regimes (jet streams, mountain waves, and convection). Highlights from ML-CIRRUS include 1) new observations of microphysical and radiative cirrus properties and their variability in meteorological regimes typical for midlatitudes, 2) insights into occurrence of in situ–formed and lifted liquid-origin cirrus, 3) validation of cloud forecasts and satellite products, 4) assessment of contrail predictability, and 5) direct observations of contrail cirrus and their distinction from natural cirrus. Hence, ML-CIRRUS provides a comprehensive dataset on cirrus in the densely populated European midlatitudes with the scope to enhance our understanding of cirrus clouds and their role for climate and weather.
- Published
- 2017
- Full Text
- View/download PDF
42. Ökonomische Evaluation von schützenden Interventionen für den Langzeitverlauf bei Depressionen (SCHILD)
- Author
-
L Hölzel, H Schwendemann, Fabian Frank, and EM Bitzer
- Published
- 2019
- Full Text
- View/download PDF
43. Was Angehörige bei Depression brauchen. Eine Fokusgruppenuntersuchung zum Informationsbedarf
- Author
-
Fabian Frank and Eva-Maria Bitzer
- Published
- 2019
- Full Text
- View/download PDF
44. Balancing network load with priority queues
- Author
-
Fabian, Frank
- Subjects
Queues (Computers) -- Research - Published
- 2001
45. Integration of security methods based of ISO/IEC 27002 standard for record management in the process of sending and receiving official documents for e-government
- Author
-
Fabian Frank Hernandez, Laura Beatriz Vidal Turrubiates, and Oscar Alberto Gonzalez Gonzalez
- Subjects
Process management ,E-Government ,Process (engineering) ,Business ,ISO/IEC 27002 - Published
- 2018
- Full Text
- View/download PDF
46. Signaling ammonium across membranes through an ammonium sensor histidine kinase
- Author
-
Susana L. A. Andrade, Haydyn D. T. Mertens, Vladimir Y. Lunin, Dmitri I. Svergun, Fabian Frank, Tobias Pflüger, Camila F. Hernández, Manfred W. Baumstark, Philipp Lewe, and Mike S. M. Jetten
- Subjects
Models, Molecular ,0301 basic medicine ,Histidine Kinase ,Science ,Protein domain ,General Physics and Astronomy ,Crystallography, X-Ray ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Bacterial Proteins ,Protein Domains ,X-Ray Diffraction ,Ammonium Compounds ,Scattering, Small Angle ,Ammonium ,Amino Acid Sequence ,Kinase activity ,lcsh:Science ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Histidine ,Binding Sites ,Multidisciplinary ,Bacteria ,Sequence Homology, Amino Acid ,Chemistry ,Cell Membrane ,Histidine kinase ,Membrane Transport Proteins ,General Chemistry ,3. Good health ,030104 developmental biology ,Anammox ,Ecological Microbiology ,Biophysics ,Phosphorylation ,lcsh:Q ,ddc:500 ,Signal transduction ,Oxidation-Reduction ,030217 neurology & neurosurgery ,Protein Binding ,Signal Transduction - Abstract
Sensing and uptake of external ammonium is essential for anaerobic ammonium-oxidizing (anammox) bacteria, and is typically the domain of the ubiquitous Amt/Rh ammonium transporters. Here, we report on the structure and function of an ammonium sensor/transducer from the anammox bacterium “Candidatus Kuenenia stuttgartiensis” that combines a membrane-integral ammonium transporter domain with a fused histidine kinase. It contains a high-affinity ammonium binding site not present in assimilatory Amt proteins. The levels of phosphorylated histidine in the kinase are coupled to the presence of ammonium, as conformational changes during signal recognition by the Amt module are transduced internally to modulate the kinase activity. The structural analysis of this ammonium sensor by X-ray crystallography and small-angle X-ray-scattering reveals a flexible, bipartite system that recruits a large uptake transporter as a sensory module and modulates its functionality to achieve a mechanistic coupling to a kinase domain in order to trigger downstream signaling events., For anammox bacteria, the sensing and uptake of ammonium is essential and specialized proteins, like Ks-Amt5, mediate such processes. Here, authors perform biophysical, biochemical, and structural analysis on Ks-Amt5 and establish a role for this protein as an ammonium-sensing signal transducer.
- Published
- 2018
- Full Text
- View/download PDF
47. Psychoedukative Gruppen für Angehörige von depressiv Erkrankten: Analyse des Informationsbedarfs durch eine Fokusgruppenuntersuchung
- Author
-
Marga Kaiser, Zivile Ries, Eva Maria Bitzer, Fabian Frank, Lars P. Hölzel, and Maria Hasenmüller
- Subjects
Gynecology ,Psychiatry and Mental health ,Clinical Psychology ,medicine.medical_specialty ,business.industry ,medicine ,business ,Applied Psychology - Abstract
Hintergrund: Depressive Storungen fuhren auch bei Angehorigen zu erheblichen Belastungen. Psychoedukative Angehorigengruppen konnen auf Angehorigenebene zur Belastungsreduktion sowie auf Ebene der erkrankten Personen zu verbesserten Krankheitsverlaufen beitragen. Um die bedurfnis- und zielgruppenorientierte Entwicklung psychoedukativer Angehorigeninterventionen zu unterstutzen, wurde der Informationsbedarf von Angehorigen von Personen mit depressiven Storungen untersucht. Methoden: Im Rahmen einer qualitativen Studie wurden 3 leitfadenbasierte Fokusgruppen mit insgesamt N=17 erwachsenen Angehorigen von Personen mit depressiven Storungen durchgefuhrt. Die Fokusgruppendiskussionen wurden auf Audiorekorder aufgenommen, transkribiert und mittels eines qualitativ-inhaltsanalytischen Analyseverfahrens ausgewertet. Ergebnisse: Der identifizierte Informationsbedarf basiert zumeist auf Informationslucken, emotionalen Belastungen sowie alltagsbezogenen Einschrankungen. Es zeigte sich ein Informationsbedarf bzgl. krankheitsspezifischer (Symptome, Verlauf und Ursachen) sowie behandlungsspezifischer (Behandlungsverfahren und Versorgungssystem) und – als zentrale Aspekte – bzgl. interaktionsspezifischer Fragestellungen (Umgang mit der erkrankten Person, Schwierigkeiten der gemeinsamen Alltagsgestaltung und Beziehungsproblematiken) sowie uber Unterstutzungsmoglichkeiten fur Angehorige und Aspekte der Selbstfursorge. Schlussfolgerungen: Im Rahmen der Angehorigenpsychoedukation sollten in der Informationsvermittlung auch Aspekte der Angehorigenbelastung und der alltagsbezogenen Einschrankung berucksichtigt werden, auf welchen der Informationsbedarf basiert. Um interaktionsbezogene Problematiken angemessen zu berucksichtigen, sollte diesen mit kompetenzorientierten Ansatzen wie bspw. Problemlosetrainings begegnet werden.
- Published
- 2015
- Full Text
- View/download PDF
48. Transkulturelle Prävention von Alkoholerkrankungen
- Author
-
Zivile Ries, J. Albicker, F. L. Komarahadi, Levente Kriston, Martin Härter, Fabian Frank, and Isaac Bermejo
- Subjects
Gynecology ,medicine.medical_specialty ,Alcohol-related disorders ,Randomized controlled trial ,law ,business.industry ,Treatment outcome ,Public Health, Environmental and Occupational Health ,medicine ,MEDLINE ,business ,law.invention - Abstract
Hintergrund Alkohol wird bei Personen mit Migrationshintergrund, insbesondere ab dem 50. Lebensjahr, zu einem Problem. Praventionsmasnahmen erreichen diese Gruppe aber nur unzulanglich. Vor diesem Hintergrund wurde ein transkulturelles Praventionskonzept zur Primarpravention alkoholbezogener Storungen entwickelt und evaluiert.
- Published
- 2015
- Full Text
- View/download PDF
49. A comprehensive laboratory study on the immersion freezing behavior of illite NX particles: a comparison of 17 ice nucleation measurement techniques
- Author
-
Christina S. McCluskey, Fabian Frank, Nadine Hoffmann, Alexei Kiselev, Ezra J. T. Levin, Thomas C. J. Hill, Katharina Dreischmeier, Takuya Tajiri, B. Nillius, Anja Danielczok, Katsuya Yamashita, Gargi Kulkarni, Carsten Budke, Thomas F. Whale, Masataka Murakami, Dennis Niedermeier, Timothy P. Wright, Yvonne Boose, Thomas Koop, Joachim Curtius, Diana Rose, Stefanie Augustin-Bauditz, Atsushi Saito, Andreas Peckhaus, Martin Ebert, Stephan Weinbruch, Heinz Bingemer, Ottmar Möhler, Karoline Diehl, Margret A. Tolbert, Benjamin J. Murray, Konrad Kandler, Paul J. DeMott, André Welti, Gregory P. Schill, Daniel O'Sullivan, Heike Wex, Zamin A. Kanji, Naruki Hiranuma, Markus D. Petters, Thomas Leisner, and John D. Hader
- Subjects
Atmospheric Science ,010504 meteorology & atmospheric sciences ,Ice crystals ,Chemistry ,Analytical chemistry ,Nucleation ,Mineralogy ,010501 environmental sciences ,Atmospheric temperature range ,01 natural sciences ,lcsh:QC1-999 ,Suspension (chemistry) ,Aerosol ,lcsh:Chemistry ,lcsh:QD1-999 ,13. Climate action ,Ice nucleus ,Particle ,Particle size ,lcsh:Physics ,0105 earth and related environmental sciences - Abstract
Immersion freezing is the most relevant heterogeneous ice nucleation mechanism through which ice crystals are formed in mixed-phase clouds. In recent years, an increasing number of laboratory experiments utilizing a variety of instruments have examined immersion freezing activity of atmospherically relevant ice-nucleating particles. However, an intercomparison of these laboratory results is a difficult task because investigators have used different ice nucleation (IN) measurement methods to produce these results. A remaining challenge is to explore the sensitivity and accuracy of these techniques and to understand how the IN results are potentially influenced or biased by experimental parameters associated with these techniques. Within the framework of INUIT (Ice Nuclei Research Unit), we distributed an illite-rich sample (illite NX) as a representative surrogate for atmospheric mineral dust particles to investigators to perform immersion freezing experiments using different IN measurement methods and to obtain IN data as a function of particle concentration, temperature (T), cooling rate and nucleation time. A total of 17 measurement methods were involved in the data intercomparison. Experiments with seven instruments started with the test sample pre-suspended in water before cooling, while 10 other instruments employed water vapor condensation onto dry-dispersed particles followed by immersion freezing. The resulting comprehensive immersion freezing data set was evaluated using the ice nucleation active surface-site density, ns, to develop a representative ns(T) spectrum that spans a wide temperature range (−37 °C < T < −11 °C) and covers 9 orders of magnitude in ns. In general, the 17 immersion freezing measurement techniques deviate, within a range of about 8 °C in terms of temperature, by 3 orders of magnitude with respect to ns. In addition, we show evidence that the immersion freezing efficiency expressed in ns of illite NX particles is relatively independent of droplet size, particle mass in suspension, particle size and cooling rate during freezing. A strong temperature dependence and weak time and size dependence of the immersion freezing efficiency of illite-rich clay mineral particles enabled the ns parameterization solely as a function of temperature. We also characterized the ns(T) spectra and identified a section with a steep slope between −20 and −27 °C, where a large fraction of active sites of our test dust may trigger immersion freezing. This slope was followed by a region with a gentler slope at temperatures below −27 °C. While the agreement between different instruments was reasonable below ~ −27 °C, there seemed to be a different trend in the temperature-dependent ice nucleation activity from the suspension and dry-dispersed particle measurements for this mineral dust, in particular at higher temperatures. For instance, the ice nucleation activity expressed in ns was smaller for the average of the wet suspended samples and higher for the average of the dry-dispersed aerosol samples between about −27 and −18 °C. Only instruments making measurements with wet suspended samples were able to measure ice nucleation above −18 °C. A possible explanation for the deviation between −27 and −18 °C is discussed. Multiple exponential distribution fits in both linear and log space for both specific surface area-based ns(T) and geometric surface area-based ns(T) are provided. These new fits, constrained by using identical reference samples, will help to compare IN measurement methods that are not included in the present study and IN data from future IN instruments.
- Published
- 2015
50. Intercomparing different devices for the investigation of ice nucleating particles using Snomax® as test substance
- Author
-
Naruki Hiranuma, Michael Rösch, Thomas Koop, Carsten Budke, Dennis Niedermeier, C. Schmidt, Fabian Frank, Susan Hartmann, Ottmar Möhler, Joachim Curtius, Stefanie Augustin-Bauditz, Frank Stratmann, Alexei Kiselev, B. Nillius, Zamin A. Kanji, Isabelle Steinke, Axel Dreyer, Karoline Diehl, Yvonne Boose, Diana Rose, Heike Wex, and Evelyn Jantsch
- Subjects
Contact angle ,Atmospheric Science ,Range (particle radiation) ,Crystallography ,Chemistry ,Slow cooling ,Ice nucleus ,Analytical chemistry ,Particle ,Nanometre ,Orders of magnitude (numbers) ,Atmospheric temperature range - Abstract
Seven different instruments and measurement methods were used to examine the immersion freezing of bacterial ice nuclei from Snomax® (hereafter Snomax), a product containing ice-active protein complexes from non-viable Pseudomonas syringae bacteria. The experimental conditions were kept as similar as possible for the different measurements. Of the participating instruments, some examined droplets which had been made from suspensions directly, and the others examined droplets activated on previously generated Snomax particles, with particle diameters of mostly a few hundred nanometers and up to a few micrometers in some cases. Data were obtained in the temperature range from −2 to −38 °C, and it was found that all ice-active protein complexes were already activated above −12 °C. Droplets with different Snomax mass concentrations covering 10 orders of magnitude were examined. Some instruments had very short ice nucleation times down to below 1 s, while others had comparably slow cooling rates around 1 K min−1. Displaying data from the different instruments in terms of numbers of ice-active protein complexes per dry mass of Snomax, nm, showed that within their uncertainty, the data agree well with each other as well as to previously reported literature results. Two parameterizations were taken from literature for a direct comparison to our results, and these were a time-dependent approach based on a contact angle distribution (Niedermeier et al., 2014) and a modification of the parameterization presented in Hartmann et al. (2013) representing a time-independent approach. The agreement between these and the measured data were good; i.e., they agreed within a temperature range of 0.6 K or equivalently a range in nm of a factor of 2. From the results presented herein, we propose that Snomax, at least when carefully shared and prepared, is a suitable material to test and compare different instruments for their accuracy of measuring immersion freezing.
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.