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1. Proton irradiation on Hydrogenated Amorphous Silicon flexible devices

Author

Menichelli, M., Aziz, S., Bashiri, A., Bizzarri, M., Buti, C., Calcagnile, L., Calvo, D., Caprai, M., Caputo, D., Caricato, A. P., Catalano, R., Cazzanelli, M., Cirio, R., Cirrone, G. A. P., Cittadini, F., Croci, T., Cuttone, G., de Cesare, G., De Remigis, P., Dunand, S., Fabi, M., Frontini, L., Grimani, C., Guarrera, M., Hasnaoui, H., Ionica, M., Kanxheri, K., Large, M., Lenta, F., Liberali, V., Lovecchio, N., Martino, M., Maruccio, G., Maruccio, L., Mazza, G., Monteduro, A. G., Morozzi, A., Nascetti, A., Pallotta, S., Papi, A., Passeri, D., Pedio, M., Petasecca, M., Petringa, G., Peverini, F., Placidi, P., Polo, M., Quaranta, A., Quarta, G., Rizzato, S., Sabbatini, F., Servoli, L., Stabile, A., Talamonti, C., Thomet, J. E., Mora, M. S. Vasquez, Villani, M., Wheadon, R. J., Wyrsch, N., Zema, N., and Tosti, L.

Subjects
Physics - Instrumentation and Detectors, Physics - Applied Physics
Abstract

Radiation damage tests in hydrogenated amorphous silicon (a-Si:H) flexible flux and dose-measuring devices have been performed with a 3 MeV proton beam, to evaluate combined displacement and total ionizing dose damage. The tested devices had two different configurations and thicknesses. The first device was a 2 um thick n-i-p diode having a 5 mm x 5 mm area. The second device was a 5 um thick charge selective contact detector having the same area. Both the devices were deposited on a flexible polyimide substrate and were irradiated up to the fluence of 1016 neq/cm2. The response to different proton fluxes has been measured before irradiation and after irradiation at 1016 neq/cm2 for charge-selective contacts and n-i-p devices. The effect of annealing for partial performance recovery at 100{\deg}C for 12 hours was also studied and a final characterization on annealed devices was performed. This test is the first combined displacement and total ionizing dose test on flexible a-Si:H devices., Comment: This paper was presented at the IEEE-RTSD2024 in Tampa (USA) with presentation number: R08-04

Published
2024

2. Interplanetarymedium monitoring with LISA: Lessons from LISA Pathfinder

Author

Cesarini A., Grimani C., Benella S., Fabi M., Sabbatini F., Villani M., and Telloni D.

Subjects
gravitational wave interferometers, magnetometers, interplanetary magnetic field, galactic cosmic rays, Meteorology. Climatology, QC851-999
Abstract

The Laser Interferometer Space Antenna (LISA) of the European Space Agency (ESA) will be the first low-frequency gravitational-wave observatory orbiting the Sun at 1 AU. The LISA Pathfinder (LPF) mission, aiming at testing the instruments to be located on board the LISA spacecraft (S/C), hosted, among the others, fluxgate magnetometers and a particle detector as parts of a diagnostics subsystem. These instruments allowed us to estimate the magnetic and Coulomb spurious forces acting on the test masses that constitute the mirrors of the interferometer. With these instruments, we also had the possibility to study the galactic cosmic-ray short term-term variations as a function of the particle energy and the associated interplanetary disturbances. Platform magnetometers and particle detectors will also be placed on board each LISA S/C. This work reports on an empirical method that allowed us to disentangle the interplanetary and onboard-generated components of the magnetic field by using the LPF magnetometer measurements. Moreover, we estimate the number and fluence of solar energetic particle events expected to be observed with the ESA Next Generation Radiation Monitor during the mission lifetime. An additional cosmic-ray detector, similar to that designed for LPF, in combination with magnetometers, would permit to observe the evolution of recurrent and non-recurrent galactic cosmic-ray variations and associated increases of the Interplanetary Magnetic Field at the transit of high-speed solar wind streams and interplanetary counterparts of coronal mass ejections. The diagnostics subsystem of LISA makes this mission also a natural multi-point observatory for space weather science investigations.

Published
2022
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3. Characterization of hydrogenated amorphous silicon sensors on polyimide flexible substrate

Author

Menichelli, M., Antognini, L., Aziz, S., Bashiri, A., Bizzarri, M., Calcagnile, L., Caprai, M., Caputo, D., Caricato, A. P., Catalano, R., Chilà, D., Cirrone, G. A. P., Croci, T., Cuttone, G., De Cesare, G., Dunand, S., Fabi, M., Frontini, L., Grimani, C., Ionica, M., Kanxheri, K., Large, M., Liberali, V., Lovecchio, N., Martino, M., Maruccio, G., Mazza, G., Monteduro, A. G., Morozzi, A., Moscatelli, F., Nascetti, A., Pallotta, S., Papi, A., Passeri, D., Pedio, M., Petasecca, M., Petringa, G., Peverini, F., Piccolo, L., Placidi, P., Quarta, G., Rizzato, S., Rossi, G., Sabbatini, F., Servoli, L., Stabile, A., Talamonti, C., Thomet, J. E., Tosti, L., Villani, M., Wheadon, R. J., Wyrsch, N., and Zema, N.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Hydrogenated amorphous silicon (a-Si:H) is a material having an intrinsically high radiation hardness that can be deposited on flexible substrates like Polyimide. For these properties a-Si:H can be used for the production of flexible sensors. a-Si:H sensors can be successfully utilized in dosimetry, beam monitoring for particle physics (x-ray, electron, gamma-ray and proton detection) and radiotherapy, radiation flux measurement for space applications (study of solar energetic particles and stellar events) and neutron flux measurements. In this paper we have studied the dosimetric x-ray response of n-i-p diodes deposited on Polyimide. We measured the linearity of the photocurrent response to x-rays versus dose-rate from which we have extracted the dosimetric x-ray sensitivity at various bias voltages. In particular low bias voltage operation has been studied to assess the high energy efficiency of these kind of sensor. A measurement of stability of x-ray response versus time has been shown. The effect of detectors annealing has been studied. Operation under bending at various bending radii is also shown.

Published
2023

4. In-flight validation of Metis Visible-light Polarimeter Coronagraph on board Solar Orbiter

Author

Liberatore, A., Fineschi, S., Casti, M., Capobianco, G., Abbo, L., Andretta, V., Da Deppo, V., Fabi, M., Frassati, F., Jerse, G., Landini, F., Moses, D., Naletto, G., Nicolini, G., Pancrazzi, M., Romoli, M., Russano, G., Sasso, C., Spadaro, D., Stangalini, M., Susino, R., Telloni, D., Teriaca, L., and Uslenghi, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Context. The Metis coronagraph is one of the remote-sensing instruments of the ESA/NASA Solar Orbiter mission. Metis is aimed at the study of the solar atmosphere and solar wind by simultaneously acquiring images of the solar corona at two different wavelengths; visible-light (VL) within a band ranging from 580 nm to 640 nm, and in the HI Ly-alpha 121.6 +/- 10 nm ultraviolet (UV) light. The visible-light channel includes a polarimeter with electro-optically modulating Liquid Crystal Variable Retarders (LCVRs) to measure the linearly polarized brightness of the K-corona to derive the electron density. Aims. In this paper, we present the first in-flight validation results of the Metis polarimetric channel together with a comparison to the on-ground calibrations. It is the validation of the first use in deep space (with hard radiation environment) of an electro-optical device: a liquid crystal-based polarimeter. Methods. We used the orientation of the K-corona's linear polarization vector during the spacecraft roll maneuvers for the in-flight calibration. Results. The first in-flight validation of the Metis coronagraph on-board Solar Orbiter shows a good agreement with the on-ground measurements. It confirms the expected visible-light channel polarimetric performance. A final comparison between the first pB obtained by Metis with the polarized brightness (pB) obtained by the space-based coronagraph LASCO and the ground-based coronagraph KCor shows the consistency of the Metis calibrated results., Comment: 8 pages, 13 figures, 3 tables, paper

Published
2023
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5. Development of thin hydrogenated amorphous silicon detectors on a flexible substrate

Author

Menichelli, M., Bizzarri, M., Calcagnile, L., Caprai, M., Caricato, A. P., Catalano, R., Cirrone, G. A. P., Croci, T., Cuttone, G., Dunand, S., Fabi, M., Frontini, L., Gianfelici, B., Grimani, C., Ionica, M., Kanxheri, K., Large, M., Liberali, V., Martino, M., Maruccio, G., Mazza, G., Monteduro, A. G., Morozzi, A., Moscatelli, F., Pallotta, S., Papi, A., Passeri, D., Pedio, M., Petasecca, M., Petringa, G., Peverini, F., Piccolo, L., Placidi, P., Quarta, G., Rizzato, S., Rossi, G., Sabbatini, F., Stabile, A., Servoli, L., Talamonti, C., Villani, M., Wheadon, R. J., and Wyrsch, N.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The HASPIDE (Hydrogenated Amorphous Silicon PIxels DEtectors) project aims at the development of thin hydrogenated amorphous silicon (a-Si:H) detectors on flexible substrates (mostly Polyimide) for beam monitoring, neutron detection and space applications. Since a-Si:H is a material with superior radiation hardness, the benefit for the above-mentioned applications can be appreciated mostly in radiation harsh environments. Furthermore, the possibility to deposit this material on flexible substrates like Polyimide (PI), polyethylene naphthalate (PEN) or polyethylene terephthalate (PET) facilitates the usage of these detectors in medical dosimetry, beam flux and beam profile measurements. Particularly interesting is its use when positioned directly on the flange of the vacuum-to-air separation interface in a beam line, as well as other applications where a thin self-standing radiation flux detector is envisaged. In this paper, the HASPIDE project will be described and some preliminary results on PI and glass substrates will be reported.

Published
2022

6. Interplanetary medium monitoring with LISA: lessons from LISA Pathfinder

Author

Cesarini, A., Grimani, C., Benella, S., Fabi, M., Sabbatini, F., Villani, M., and Telloni, D.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Space Physics
Abstract

The Laser Interferometer Space Antenna (LISA) of the European Space Agency (ESA) will be the first low-frequency gravitational-wave observatory orbiting the Sun at 1 AU. The LISA Pathfinder (LPF) mission, aiming at testing of the instruments to be located on board the LISA spacecraft (S/C), hosted, among the others, fluxgate magnetometers and a particle detector as parts of a diagnostics subsystem. These instruments allowed us for the estimate of the magnetic and Coulomb spurious forces acting on the test masses that constitute the mirrors of the interferometer. With these instruments we also had the possibility to study the galactic cosmic-ray short term-term variations as a function of the particle energy and the associated interplanetary disturbances. Platform magnetometers and particle detectors will be also placed on board each LISA S/C. This work reports about an empirical method that allowed us to disentangle the interplanetary and onboard-generated components of the magnetic field by using the LPF magnetometer measurements. Moreover, we estimate the number and fluence of solar energetic particle events expected to be observed with the ESA Next Generation Radiation Monitor during the mission lifetime. An additional cosmic-ray detector, similar to that designed for LPF, in combination with magnetometers, would permit to observe the evolution of recurrent and non-recurrent galactic cosmic-ray variations and associated increases of the interplanetary magnetic field at the transit of high-speed solar wind streams and interplanetary counterparts of coronal mass ejections. The diagnostics subsystem of LISA makes this mission also a natural multi-point observatory for space weather science investigations., Comment: Accepted for publication Journal of Space Weather and Space Climate (JSWSC)

Published
2022

8. The Strange Career of a Black Utopia

Author

Fabi, M. Giulia

Subjects
African American fiction. Afrofuturism. Charles Henry Holmes. Science fiction. Utopia, Language and Literature, Language. Linguistic theory. Comparative grammar, P101-410
Abstract

This essay presents archival information about Charles H. Holmes and argues that his understudied novel, Ethiopia, The Land of Promise (1917), represents an important chapter in the history of Afrofuturism and American speculative fiction. The literary critical relevance of Ethiopia emerges forcefully from Holmes’s intertextual dialogue with other utopian and science fiction authors, such as Martin R. Delany, Sutton E. Griggs, Pauline E. Hopkins, Frances E.W. Harper, Edward Bellamy, and W.E.B. Du Bois. Holmes’s critique of Jim Crow segregation enables the articulation of a “distinctly revolutionary” project for African American futurity.

Published
2024
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11. First light observations of the solar wind in the outer corona with the Metis coronagraph

Author

Romoli, M., Antonucci, E., Andretta, V., Capuano, G. E., Da Deppo, V., De Leo, Y., Downs, C., Fineschi, S., Heinzel, P., Landini, F., Liberatore, A., Naletto, G., Nicolini, G., Pancrazzi, M., Sasso, C., Spadaro, D., Susino, R., Telloni, D., Teriaca, L., Uslenghi, M., Wang, Y. M., Bemporad, A., Capobianco, G., Casti, M., Fabi, M., Frassati, F., Frassetto, F., Giordano, S., Grimani, C., Jerse, G., Magli, E., Massone, G., Messerotti, M., Moses, D., Pelizzo, M. G., Romano, P., Schühle, U., Slemer, A., Stangalini, M., Straus, T., Volpicelli, C. A., Zangrilli, L., Zuppella, P., Abbo, L., Auchére, F., Cuadrado, R. Aznar, Berlicki, A., Bruno, R., Ciaravella, A., D'Amicis, R., Lamy, P., Lanzafame, A., Malvezzi, A. M., Nicolosi, P., Nisticò, G., Peter, H., Plainaki, C., Poletto, L., Reale, F., Solanki, S. K., Strachan, L., Tondello, G., Tsinganos, K., Velli, M., Ventura, R., Vial, J. C., Woch, J., and Zimbardo, G.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The investigation of the wind in the solar corona initiated with the observations of the resonantly scattered UV emission of the coronal plasma obtained with UVCS-SOHO, designed to measure the wind outflow speed by applying the Doppler dimming diagnostics. Metis on Solar Orbiter complements the UVCS spectroscopic observations, performed during solar activity cycle 23, by simultaneously imaging the polarized visible light and the HI Ly-alpha corona in order to obtain high-spatial and temporal resolution maps of the outward velocity of the continuously expanding solar atmosphere. The Metis observations, on May 15, 2020, provide the first HI Ly-alpha images of the extended corona and the first instantaneous map of the speed of the coronal plasma outflows during the minimum of solar activity and allow us to identify the layer where the slow wind flow is observed. The polarized visible light (580-640 nm), and the UV HI Ly-alpha (121.6 nm) coronal emissions, obtained with the two Metis channels, are combined in order to measure the dimming of the UV emission relative to a static corona. This effect is caused by the outward motion of the coronal plasma along the direction of incidence of the chromospheric photons on the coronal neutral hydrogen. The plasma outflow velocity is then derived as a function of the measured Doppler dimming. The static corona UV emission is simulated on the basis of the plasma electron density inferred from the polarized visible light. This study leads to the identification, in the velocity maps of the solar corona, of the high-density layer about +/-10 deg wide, centered on the extension of a quiet equatorial streamer present at the East limb where the slowest wind flows at about (160 +/- 18) km/s from 4 Rs to 6 Rs. Beyond the boundaries of the high-density layer, the wind velocity rapidly increases, marking the transition between slow and fast wind in the corona.

Published
2021
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12. Cosmic-ray flux predictions and observations for and with Metis on board Solar Orbiter

Author

Grimani, C., Andretta, V., Chioetto, P., Da Deppo, V., Fabi, M., Gissot, S., Naletto, G., Persici, A., Plainaki, C., Romoli, M., Sabbatini, F., Spadaro, D., Stangalini, M., Telloni, D., Uslenghi, M., Antonucci, E., Bemporad, A., Capobianco, G., Capuano, G., Casti, M., De Leo, Y., Fineschi, S., Frassati, F., Frassetto, F., Heinzel, P., Jerse, G., Landini, F., Liberatore, A., Magli, E., Messerotti, M., Moses, D., Nicolini, G., Pancrazzi, M., Pelizzo, M. G., Romano, P., Sasso, C., Schühle, U., Slemer, A., Straus, T., Susino, R., Teriaca, L., Volpicelli, C. A., von Forstner, J. L. Freiherr, and Zuppella, P.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Metis coronagraph is one of the remote sensing instruments hosted on board the ESA/NASA Solar Orbiter mission. Metis is devoted to carry out the first simultaneous imaging of the solar corona in both visible light (VL) and ultraviolet (UV). High-energy particles penetrate spacecraft materials and may limit the performance of on-board instruments. A study of galactic cosmic-ray (GCR) tracks observed in the first VL images gathered by Metis during the commissioning phase for a total of 60 seconds of exposure time is presented here. A similar analysis is planned for the UV channel. A prediction of the GCR flux up to hundreds of GeV is made here for the first part of the Solar Orbiter mission to study the Metis coronagraph performance. GCR model predictions are compared to observations gathered on board Solar Orbiter by the EPD/HET experiment in the range 10 MeV-100 MeV in the summer 2020 and with previous measurements. Estimated cosmic-ray fluxes above 70 MeV n$^{-1}$ have been also parameterized and used for Monte Carlo simulations aiming at reproducing the cosmic-ray track observations in the Metis coronagraph VL images. The same parameterizations can also be used to study the performance of other detectors. By comparing observations of cosmic-ray tracks in the Metis VL images with FLUKA Monte Carlo simulations of cosmic-ray interactions in the VL detector, it is found that cosmic rays fire a fraction of the order of 10$^{-4}$ of the whole image pixel sample. Therefore, cosmic rays do not affect sensibly the quality of Metis VL images. It is also found that the overall efficiency for cosmic-ray identification in the Metis VL images is approximately equal to the contribution of Z$>$2 particles. As a result, the Metis coronagraph may play the role of a proton monitor for long-term GCR variations during the overall mission duration., Comment: 11 pages, 7 figures, accepted for publication on Astronomy & Astrophysics

Published
2021
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14. FPGA Accelerated QRD-Based Matrix Inversion Core for Signal Processing

Author

Shibin Fabi, M., Kidav, Jayaraj U., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Singh, Sri Niwas, editor, Mahanta, Saurov, editor, and Singh, Yumnam Jayanta, editor

Published
2023
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15. Forbush decreases and $<$ 2-day GCR flux non-recurrent variations studied with LISA Pathfinder

Author

Grimani, C., Armano, M., Audley, H., Baird, J., Benella, S., Binetruy, P., Born, M., Bortoluzzi, D., Castelli, E., Cavalleri, A., Cesarini, A., Cruise, A. M., Danzmann, K., Silva, M. de Deus, Diepholz, I., Dixon, G., Dolesi, R., Fabi, M., Ferraioli, L., Ferroni, V., Finetti, N., Fitzsimons, E. D., Freschi, M., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grzymisch, J., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspé, H., Jennrich, O., Jetzer, P., Karnesis, N., Kaune, B., Korsakova, N., Killow, C. J., Kudela, K., Laurenza, M., Lobo, J. A., Lloro, I., Liu, L., López-Zaragoza, J. P., Maarschalkerweerd, R., Mance, D., Meshksar, N., Martín, V., Martin-Polo, L., Martino, J., Martin-Porqueras, F., Mateos, I., McNamara, P. W., Mendes, J., Mendes, L., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Ramos-Castro, J., Reiche, J., Robertson, D. I., Rivas, F., Russano, G., Slutsky, J., Sopuerta, C. F., Sumner, T., Telloni, D., Texier, D., Thorpe, J. I., Vetrugno, D., Villani, M., Vitale, S., Wanner, G., Ward, H., Wass, P., Weber, W. J., Wissel, L., Wittchen, A., and Zweifel, P.

Subjects
Physics - Space Physics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Non-recurrent short term variations of the galactic cosmic-ray (GCR) flux above 70 MeV n$^{-1}$ were observed between 2016 February 18 and 2017 July 3 aboard the European Space Agency LISA Pathfinder (LPF) mission orbiting around the Lagrange point L1 at 1.5$\times$10$^6$ km from Earth. The energy dependence of three Forbush decreases (FDs) is studied and reported here. A comparison of these observations with others carried out in space down to the energy of a few tens of MeV n$^{-1}$ shows that the same GCR flux parameterization applies to events of different intensity during the main phase. FD observations in L1 with LPF and geomagnetic storm occurrence is also presented. Finally, the characteristics of GCR flux non-recurrent variations (peaks and depressions) of duration $<$ 2 days and their association with interplanetary structures are investigated. It is found that, most likely, plasma compression regions between subsequent corotating high-speed streams cause peaks, while heliospheric current sheet crossing cause the majority of the depressions.

Published
2019
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17. Characteristics and energy dependence of recurrent galactic cosmic-ray flux depressions and of a Forbush decrease with LISA Pathfinder

Author

Armano, M., Audley, H., Baird, J., Bassan, M., Benella, S., Binetruy, P., Born, M., Bortoluzzi, D., Cavalleri, A., Cesarini, A., Cruise, A. M., Danzmann, K., Silva, M. de Deus, Diepholz, I., Dixon, G., Dolesi, R., Fabi, M., Ferraioli, L., Ferroni, V., Finetti, N., Fitzsimons, E. D., Freschi, M., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grimani, C., Grzymisch, J., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspé, H., Jennrich, O., Jetzer, P., Karnesis, N., Kaune, B., Korsakova, N., Killow, C. J., Laurenza, M., Lobo, J. A., Lloro, I., Liu, L., López-Zaragoza, J. P., Maarschalkerweerd, R., Mance, D., Martín, V., Martin-Polo, L., Martino, J., Martin-Porqueras, F., Mateos, I., McNamara, P. W., Mendes, J., Mendes, L., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Ramos-Castro, J., Reiche, J., Robertson, D. I., Rivas, F., Russano, G., Sabbatini, F., Slutsky, J., Sopuerta, C. F., Sumner, T., Telloni, D., Texier, D., Thorpe, J. I., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Wass, P., Weber, W. J., Wissel, L., Wittchen, A., Zambotti, A., Zanoni, C., and Zweifel, P.

Subjects
Physics - Space Physics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract

Galactic cosmic-ray (GCR) energy spectra observed in the inner heliosphere are modulated by the solar activity, the solar polarity and structures of solar and interplanetary origin. A high counting rate particle detector (PD) aboard LISA Pathfinder (LPF), meant for subsystems diagnostics, was devoted to the measurement of galactic cosmic-ray and solar energetic particle integral fluxes above 70 MeV n$^{-1}$ up to 6500 counts s$^{-1}$. PD data were gathered with a sampling time of 15 s. Characteristics and energy-dependence of GCR flux recurrent depressions and of a Forbush decrease dated August 2, 2016 are reported here. The capability of interplanetary missions, carrying PDs for instrument performance purposes, in monitoring the passage of interplanetary coronal mass ejections (ICMEs) is also discussed.

Published
2018
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19. HASPIDE: a project for the development of hydrogenated amorphous silicon radiation sensors on a flexible substrate

Author

Tosti, L., primary, Antognini, L., additional, Aziz, S., additional, Bashiri, A., additional, Calcagnile, L., additional, Caputo, D., additional, Caricato, A.P., additional, Catalano, R., additional, De Cesare, G., additional, Chilà, D., additional, Cirrone, G.A.P., additional, Croci, T., additional, Cuttone, G., additional, Dunand, S., additional, Fabi, M., additional, Frontini, L., additional, Grimani, C., additional, Ionica, M., additional, Kanxheri, K., additional, Large, M., additional, Liberali, V., additional, Lovecchio, N., additional, Martino, M., additional, Maruccio, G., additional, Mazza, G., additional, Menichelli, M., additional, Monteduro, A.G., additional, Morozzi, A., additional, Moscatelli, F., additional, Nascetti, A., additional, Pallotta, S., additional, Passeri, D., additional, Pedio, M., additional, Petasecca, M., additional, Petringa, G., additional, Peverini, F., additional, Piccolo, L., additional, Placidi, P., additional, Quarta, G., additional, Rizzato, S., additional, Sabbatini, F., additional, Servoli, L., additional, Stabile, A., additional, Talamonti, C., additional, Thomet, J.E., additional, Villani, M., additional, Wheadon, R.J., additional, Wyrsch, N., additional, and Zema, N., additional

Published
2024
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21. CUTTING-EDGE A-SI:H DOSIMETER TO OPERATE IN VERY DEMANDING RADIOTHERAPY APPLICATIONS

Author

Talamonti, C., primary, Petasecca, M., additional, Pallotta, S., additional, Large, M., additional, Grimani, C., additional, Calcagnile, L., additional, Caricato, A.P., additional, Cirrone, G.A.P., additional, Croci, T., additional, Cuttone, G., additional, Dunand, S., additional, Fabi, M., additional, Frontini, L., additional, Ionica, M., additional, Kanxheri, K., additional, Liberali, V., additional, Martino, M., additional, Maruccio, G., additional, Mazza, G., additional, Menichelli, M., additional, Monteduro, A.G., additional, Morozzi, A., additional, Moscatelli, F., additional, Passeri, D., additional, Pedio, M., additional, Pedringa, G., additional, Peverini, F., additional, Piccolo, L., additional, Placidi, P., additional, Quarta, G., additional, Rizzato, S., additional, Sabbatini, F., additional, Stabile, A., additional, Wheadon, R.J., additional, Wyrsch, N., additional, Villani, M., additional, and Servoli, L., additional

Published
2023
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23. Particle monitoring capability of the Solar Orbiter Metis coronagraph through the increasing phase of solar cycle 25

Author

Grimani, C., primary, Andretta, V., additional, Antonucci, E., additional, Chioetto, P., additional, Da Deppo, V., additional, Fabi, M., additional, Gissot, S., additional, Jerse, G., additional, Messerotti, M., additional, Naletto, G., additional, Pancrazzi, M., additional, Persici, A., additional, Plainaki, C., additional, Romoli, M., additional, Sabbatini, F., additional, Spadaro, D., additional, Stangalini, M., additional, Telloni, D., additional, Teriaca, L., additional, Uslenghi, M., additional, Villani, M., additional, Abbo, L., additional, Burtovoi, A., additional, Frassati, F., additional, Landini, F., additional, Nicolini, G., additional, Russano, G., additional, Sasso, C., additional, and Susino, R., additional

Published
2023
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24. In-flight radiometric calibration of the Metis Visible Light channel using stars and comparison with STEREO-A/COR2 data

Author

De Leo, Y., primary, Burtovoi, A., additional, Teriaca, L., additional, Romoli, M., additional, Chioetto, P., additional, Andretta, V., additional, Uslenghi, M., additional, Landini, F., additional, Susino, R., additional, Pancrazzi, M., additional, Frassati, F., additional, Giarrusso, M., additional, Giordano, S., additional, Zangrilli, L., additional, Spadaro, D., additional, Abbo, L., additional, Bemporad, A., additional, Capobianco, G., additional, Capuano, G. E., additional, Casini, C., additional, Casti, M., additional, Corso, A. J., additional, Da Deppo, V., additional, Fabi, M., additional, Fineschi, S., additional, Frassetto, F., additional, Grimani, C., additional, Guglielmino, S. L., additional, Heinzel, P., additional, Jerse, G., additional, Liberatore, A., additional, Magli, E., additional, Massone, G., additional, Messerotti, M., additional, Moses, J. D., additional, Naletto, G., additional, Nicolini, G., additional, Pelizzo, M. G., additional, Romano, P., additional, Russano, G., additional, Sasso, C., additional, Schühle, U., additional, Straus, T., additional, Slemer, A., additional, Stangalini, M., additional, Telloni, D., additional, Volpicelli, C. A., additional, and Zuppella, P., additional

Published
2023
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25. Theoretical, on-ground, and in-flight study of the Metis coronagraph vignetting

Author

Casini, C., primary, Chioetto, P., additional, De Leo, Y., additional, Da Deppo, V., additional, Zuppella, P., additional, Frassetto, F., additional, Romoli, M., additional, Landini, F., additional, Pancrazzi, M., additional, Andretta, V., additional, Bemporad, A., additional, Corso, A. J., additional, Fabi, M., additional, Fineschi, S., additional, Frassati, F., additional, Grimani, C., additional, Jerse, G., additional, Liberatore, A., additional, Magli, E., additional, Naletto, G., additional, Nicolini, G., additional, Pelizzo, M. G., additional, Romano, P., additional, Sasso, C., additional, Schuehle, U., additional, Spadaro, D., additional, Stangalini, M., additional, Straus, T., additional, Susino, R., additional, Teriaca, L., additional, Uslenghi, M., additional, Casti, M., additional, Heinzel, P., additional, and Volpicelli, A., additional

Published
2023
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26. Understanding the environmental factors related to the decrease in Pediatric Emergency Department referrals for acute asthma during the SARS-CoV-2 pandemic

Author

Dondi, A, Betti, L, Carbone, C, Dormi, A, Paglione, M, Rinaldi, M, Gualtieri, M, Scotto, F, Poluzzi, V, Fabi, M, Lanari, M, Dondi A., Betti L., Carbone C., Dormi A., Paglione M., Rinaldi M., Gualtieri M., Scotto F., Poluzzi V., Fabi M., Lanari M., Dondi, A, Betti, L, Carbone, C, Dormi, A, Paglione, M, Rinaldi, M, Gualtieri, M, Scotto, F, Poluzzi, V, Fabi, M, Lanari, M, Dondi A., Betti L., Carbone C., Dormi A., Paglione M., Rinaldi M., Gualtieri M., Scotto F., Poluzzi V., Fabi M., and Lanari M.

Abstract

Background: Lockdown measures during the SARS-CoV-2 pandemic determined radical changes to behavioral and social habits, that were reflected by a reduction in the transmission of respiratory pathogens and in anthropogenic atmospheric emissions. Objective: This ecological study aims to provide a descriptive evaluation on how restrictive measures during the SARS-CoV-2 pandemic impacted Pediatric Emergency Department (PED) referrals for asthma exacerbations, and their potentially associated environmental triggers in Bologna, a densely populated urban area in Northern Italy. Methods: Files of children evaluated for acute asthma during 2015 to 2020 at the PED of Sant'Orsola University Hospital of Bologna were retrospectively reviewed. Historical daily concentration records of particulate (PM2.5, PM10) and gaseous (NO2, C6H6) air pollutants, and pollen were concurrently evaluated, including specific PM chemical tracers for traffic-related air pollution (TRAP). Results: In 2020, asthma-related PED referrals decreased compared to referral rates of the previous 5 years (p < 0.01). This effect was particularly marked during the first lockdown period (March to May), when the drastic drop in PED referrals was associated with a reduction of high-priority cases up to 85% and by 54%, on average. A concomitant reduction in the concentrations of traffic-related air pollutants was observed in the range of 40%–60% (p < 0.01). Conclusions: The lower rate of asthma exacerbations in childhood was in this study paralleled with reduced TRAP levels during the pandemic. Synergic interactions of the multiple consequences of lockdowns likely contributed to the reduced exacerbations, including decreased exposure to ambient pollutants and fewer respiratory infections, identified as the most important factor in the literature.

Published
2022

27. POS0744 MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN ACROSS 16 LATIN AMERICAN COUNTRIES: A MULTICENTER STUDY FROM THE REKAMLATINA NETWORK

Author

Garcia-Silva, J., primary, Ulloa-Gutierrez, R., additional, Ivankovich Escoto, G., additional, Yamazaki-Nakashimada, M. A., additional, Faugier Fuentes, E., additional, Del Águila, O., additional, Villlarreal, A. V., additional, Camacho Moreno, G., additional, Estripeaut, D., additional, Gutiérrez, I. F., additional, Castillo-Bustamante, D., additional, Luciani, K., additional, Fabi, M., additional, Espada, G., additional, Pringue, A., additional, Álvarez-Olmos, M. I., additional, Silfa, C., additional, García-Domínguez, M., additional, Pérez-Camacho, P., additional, Duarte-Passos, S., additional, Borjas Aguilar, K. L., additional, Cervi, M. C., additional, Martínez-Ramírez, R. O., additional, Cantillano, E. M., additional, Llamas-Guillén, B. A., additional, Velázquez-Méndez, M., additional, Saltigeral-Simental, P., additional, Criales, J., additional, Tremoulet, A. H., additional, and Rekamlatina- Mis-C Study Group Investigators, T., additional

Published
2023
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28. In-flight validation of the Metis visible-light polarimeter coronagraph on board Solar Orbiter

Author

Liberatore, A., primary, Fineschi, S., additional, Casti, M., additional, Capobianco, G., additional, Abbo, L., additional, Andretta, V., additional, Da Deppo, V., additional, Fabi, M., additional, Frassati, F., additional, Jerse, G., additional, Landini, F., additional, Moses, D., additional, Naletto, G., additional, Nicolini, G., additional, Pancrazzi, M., additional, Romoli, M., additional, Russano, G., additional, Sasso, C., additional, Spadaro, D., additional, Stangalini, M., additional, Susino, R., additional, Telloni, D., additional, Teriaca, L., additional, and Uslenghi, M., additional

Published
2023
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29. MO-04.13 - CUTTING-EDGE A-SI:H DOSIMETER TO OPERATE IN VERY DEMANDING RADIOTHERAPY APPLICATIONS

Author

Talamonti, C., Petasecca, M., Pallotta, S., Large, M., Grimani, C., Calcagnile, L., Caricato, A.P., Cirrone, G.A.P., Croci, T., Cuttone, G., Dunand, S., Fabi, M., Frontini, L., Ionica, M., Kanxheri, K., Liberali, V., Martino, M., Maruccio, G., Mazza, G., Menichelli, M., Monteduro, A.G., Morozzi, A., Moscatelli, F., Passeri, D., Pedio, M., Pedringa, G., Peverini, F., Piccolo, L., Placidi, P., Quarta, G., Rizzato, S., Sabbatini, F., Stabile, A., Wheadon, R.J., Wyrsch, N., Villani, M., and Servoli, L.

Published
2023
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31. X-ray qualification of hydrogenated amorphous silicon sensors on flexible substrate

Author

Menichelli, M., Antognini, L., Bashiri, A., Bizzarri, M., Calcagnile, L., Caprai, M., Caricato, A. P., Catalano, R., Cirrone, G. A. P., Croci, T., Cuttone, G., Dunand, S., Fabi, M., Frontini, L., Grimani, C., Ionica, M., Kanxheri, K., Large, M., Liberali, V., Martino, M., Maruccio, G., Mazza, G., Monteduro, A. G., Morozzi, A., Moscatelli, F., Pallotta, S., Papi, A., Passeri, D., Pedio, M., Petasecca, M., Petringa, G., Peverini, F., Piccolo, L., Placidi, P., Quarta, G., Rizzato, S., Rossi, G., Sabbatini, F., Stabile, A., Servoli, L., Talamonti, C., Tosti, L., Villani, M., Wheadon, R. J., Wyrsch, N., and Zema, N.

Subjects
Neutrons, Flexible detectors, Sensitivity, Polyethylene, Particle measurements, Sensitivity, Polyethylene, PIN photodiodes, Detectors, Polyimides, Neutrons, Particle measurements, Hydrogenated Silicon detectors, Radiation Hardness, Flexible detectors, Polyimides, Detectors, PIN photodiodes, Hydrogenated Silicon detectors, Radiation Hardness
Published
2023

35. Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey

Author

Cattalini M, Della Paolera S, Zunica F, Bracaglia C, Giangreco M, Verdoni L, Meini A, Sottile R, Caorsi R, Zuccotti G, Fabi M, Montin D, Meneghel A, Consolaro A, Dellepiane RM, Maggio MC, La Torre F, Marchesi A, Simonini G, Villani A, Cimaz R, Ravelli A, Taddio A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities 'G. D’Alessandro', University of Palermo, Palermo Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU 'Policlinico - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan Italy, Veronica Bennato: U. O. Pediatria, Ospedale A, Manzoni Lecco, Francesca Biscaro: UOC Pediatria, Ospedale Ca’ Foncello, Treviso, Grazia Bossi: UOC Pediatria, Fondazione IRCCS Policlinico San Matteo, Pavia Italy, Andrea Campana: Bambino Gesù Children’s Hospital, Rome Italy, Maurizio Carone: UO Malattie Infettive, Ospedale Pediatrico ‘Giovanni XXIII’, Bari Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario 'G. Martino', Eleonora Dei Rossi: University of Trieste, Trieste Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological Sciences, Sapeinza University of Rome, Polo Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O. Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s Hospital, Piazza S. Onofrio n. 4, 00165 Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biago e C. Arrigo, Alessandria Italy, Giovanni Filocamo: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano, Ilenia Floretta: Pediatria, Ospedale Santa Chiara, Trento Italy, Maria Loreta Foschini: SC Pediatria, PO SAN MICHELE AOBrotzu, Cagliari Italy, Marcello Lanari: Department of Pediatrics, University of Bologna, IRCCS S. Orsola-Malpighi Hospital, Bologna Italy, Bianca Lattanzi: SOD Pediatria, Ospedali Riuniti, Ancona Italy, Alessandra Lazzerotti: Clinica Pediatrica, Università Milano Bicocca, Fondazione MBBM - onlus c/o Ospedale San Gerardo, Monza Italy, Francesco Licciardi: Department of Pediatrics and Public Health, University of Turin, Turin Italy, Alessandra Manerba: Child Cardiology, ASST Spedali Civili di Brescia and University of Brescia, Brescia Italy, Savina Mannarino: Division of Cardiology, Children’s Hospital V Buzzi, ASST FBF Sacco, Achille Marino: Department of Pediatrics, Desio Hospital, ASST Monza, Desio Italy, Agostina Marolda: Pediatrics and Neonatology Dipartment, ASST Ovest Milanese, 'G. Fornaroli' Hospital, Magenta Milan, Laura Martelli: Paediatric Department, Hospital Papa Giovanni XXIII, Bergamo Italy, Giorgia Martini, Department of Woman’s and Child’s Health, University of Padova, Padua Italy, Angela Mauro: Department of Paediatrics, Emergency Department, Santobono-Pausilipon Children’s Hospital, Naples, Italy. Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, AOU Meyer, University of Florence, Florence, Italy. Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di Bologna, Francesca Minoia: Fondazione IRCCS Cà Granda, Alma Olivieri: Dipartimento della donna, del bambino e di chirurgia generale e specialistica, Università della Campania, 'L Vanvitelli, Napoli, Guido Pennoni: Dipartimento Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria e Neonatologia, ASST Lodi, Lodi, Francesca Ricci, Clinica Pediatrica, ASST Spedali Civili di Brescia e Università degli Studi di Brescia, Donato Rigante: Department of Pediatrics, Univarsità Cattolica Sacro Cuore, Matilde Rossi: UOC di Pediatrai e Neonatologia, Ospedale di Macerata, Macerata, Claudia Santagati: Dipartimento di Pediatria, Ospedale di Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of Trieste, Domenico Sperlì: UOC di Pediatria, S. O. 'Annunziata' - A. O. di Cosenza, Sara Stucchi: Maternal and Child Health, Division of Paediatrics, ASST Grande Ospedale Metropolitano Niguarda, Milano Italy, Barbara Teruzzi: Maternal and Child Health, Elpidio Tierno: UOC di Pediatria, Dipartimento della Salute della Donna e del Bambin, AORN 'Sant’Anna e San Sebastiano'- Caserta, Tatiana Utytatnikova: Dipartimento Materno-Infantile, Pediatria, ASST Bergamo-EST, Seriate Bergamo, Piero Valentini, Department of Pediatrics, Gianluca Vergine, UOC Pediatria Rimini, Ospedale Infermi, ASL Romagna, Rimini Italy., Cattalini, Marco, Della Paolera, Sara, Zunica, Fiammetta, Bracaglia, Claudia, Giangreco, Manuela, Verdoni, Lucio, Meini, Antonella, Sottile, Rita, Caorsi, Roberta, Zuccotti, Gianvincenzo, Fabi, Marianna, Montin, Davide, Meneghel, Alessandra, Consolaro, Alessandro, Dellepiane, Rosa Maria, Maggio, Maria Cristina, La Torre, Francesco, Marchesi, Alessandra, Simonini, Gabriele, Villani, Alberto, Cimaz, Rolando, Ravelli, Angelo, Taddio, Andrea, Cattalini, M, Della Paolera, S, Zunica, F, Bracaglia, C, Giangreco, M, Verdoni, L, Meini, A, Sottile, R, Caorsi, R, Zuccotti, G, Fabi, M, Montin, D, Meneghel, A, Consolaro, A, Dellepiane, Rm, Maggio, Mc, La Torre, F, Marchesi, A, Simonini, G, Villani, A, Cimaz, R, Ravelli, A, Taddio, A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile, Care, Internal Medicine and Medical Specialities 'G., D’Alessandro', University of, Palermo, Palermo, Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU 'Policlinico, - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care, Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore, Policlinico, Milan, Italy, Veronica Bennato: U. O., Pediatria, Ospedale, A, Manzoni, Lecco, Francesca Biscaro: UOC, Pediatria, Ospedale Ca’, Foncello, Treviso, Grazia Bossi: UOC, Pediatria, Fondazione IRCCS Policlinico San, Matteo, Pavia, Italy, Andrea Campana: Bambino Gesù Children’s, Hospital, Rome, Italy, Maurizio Carone: UO Malattie, Infettive, Ospedale Pediatrico ‘Giovanni, Xxiii’, Bari, Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario 'G. Martino', Eleonora Dei Rossi: University of, Trieste, Trieste, Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological, Science, Sapeinza University of, Rome, Polo, Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O., Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s, Hospital, Piazza, S. Onofrio n. 4., 00165, Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency, Unit, The Children, Hospital, AO SS Antonio e Biago e C., Arrigo, Alessandria, Italy, Giovanni Filocamo: Fondazione IRCCS Cà, Granda, Ospedale Maggiore, Policlinico, Milano, Ilenia Floretta:, Pediatria, Ospedale Santa, Chiara, Trento, Italy, Maria Loreta Foschini: SC, Pediatria, PO SAN MICHELE, Aobrotzu, Cagliari, Italy, Marcello Lanari: Department of, Pediatric, University of, Bologna, IRCCS S., Orsola-Malpighi Hospital, Bologna, Italy, Bianca Lattanzi: SOD, Pediatria, Ospedali, Riuniti, Ancona, Italy, Alessandra Lazzerotti: Clinica, Pediatrica, Università Milano, Bicocca, Fondazione MBBM, - onlus c/o Ospedale San Gerardo, Monza, Italy, Francesco Licciardi: Department of Pediatrics and Public, Health, University of, Turin, Turin, Italy, Alessandra Manerba: Child, Cardiology, ASST Spedali Civili di Brescia and University of, Brescia, Brescia, Italy, Savina Mannarino: Division of, Cardiology, Children’s Hospital, V Buzzi, ASST FBF, Sacco, Achille Marino: Department of, Pediatric, Desio, Hospital, Asst, Monza, Desio, Italy, Agostina Marolda: Pediatrics and Neonatology, Dipartment, ASST Ovest, Milanese, 'G., Fornaroli' Hospital, Magenta, Milan, Laura Martelli: Paediatric, Department, Hospital Papa Giovanni, Xxiii, Bergamo, Italy, Giorgia, Martini, Department of Woman’s and Child’s, Health, University of, Padova, Padua, Italy, Angela Mauro: Department of, Paediatric, Emergency, Department, Santobono-Pausilipon Children’s, Hospital, Naples, Italy., Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, Aou, Meyer, University of, Florence, Florence, Italy., Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica, Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di, Bologna, Francesca Minoia: Fondazione IRCCS Cà, Granda, Alma Olivieri: Dipartimento della, Donna, del bambino e di chirurgia generale, e specialistica, Università della, Campania, 'L, Vanvitelli, Napoli, Claudio, Guido Pennoni: Dipartimento, Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria, e Neonatologia, Asst, Lodi, Lodi, Francesca, Ricci, Clinica, Pediatrica, ASST Spedali Civili di Brescia, e Università degli Studi di Brescia, Donato Rigante: Department of, Pediatric, Univarsità Cattolica Sacro, Cuore, Matilde Rossi: UOC di Pediatrai, e Neonatologia, Ospedale di, Macerata, Macerata, Claudia Santagati: Dipartimento di, Pediatria, Ospedale di, Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of, Trieste, Domenico Sperlì: UOC di Pediatria, S. O. 'Annunziata' - A. O. di Cosenza, Sara Stucchi: Maternal and Child, Health, Division of, Paediatric, ASST Grande Ospedale Metropolitano, Niguarda, Milano, Italy, Barbara Teruzzi: Maternal and Child, Health, Elpidio Tierno: UOC di, Pediatria, Dipartimento della Salute della Donna, e del Bambin, AORN 'Sant’Anna, e San Sebastiano'- Caserta, Tatiana Utytatnikova: Dipartimento, Materno-Infantile, Pediatria, Asst, Bergamo-EST, Seriate, Bergamo, Piero, Valentini, Department of, Pediatric, Gianluca, Vergine, UOC Pediatria, Rimini, Ospedale, Infermi, Asl, Romagna, Rimini, Italy., Cattalini M., Della Paolera S., Zunica F., Bracaglia C., Giangreco M., Verdoni L., Meini A., Sottile R., Caorsi R., Zuccotti G., Fabi M., Montin D., Meneghel A., Consolaro A., Dellepiane R.M., Maggio M.C., La Torre F., Marchesi A., Simonini G., Villani A., Cimaz R., Ravelli A., Taddio A., Adamoli P., Alberelli M.C., Alizzi C., Barone P., Bennato V., Biscaro F., Bossi G., Campana A., Carone M., Civino A., Conti G., Rossi E.D., Del Giudice E., Dell'Anna A., De Luca M., Felici E., Filocamo G., Floretta I., Foschini M.L., Lanari M., Lattanzi B., Lazzerotti A., Licciardi F., Manerba A., Mannarino S., Marino A., Marolda A., Martelli L., Martini G., Mauro A., Mastrolia M.V., Mazza A., Miniaci A., Minoia F., Olivieri A., Pennoni G., Pignataro R., Ricci F., Rigante D., Rossi M., Santagati C., Soliani M., Sonego S., Sperli D., Stucchi S., Teruzzi B., Tierno E., Utytatnikova T., Valentini P., and Vergine G.

Subjects
Coronary artery abnormalities, Hypotension, Kawasaki disease, Multisystem inflammatory syndrome associated with coronavirus disease, Myocarditis, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, SARS-CoV-2, Age Distribution, Antirheumatic Agents, Aspirin, C-Reactive Protein, COVID-19, Child, Child, Preschool, Coronary Artery Disease, Cough, Diarrhea, Dyspnea, Female, Glucocorticoids, Heart Failure, Humans, Hyperferritinemia, Immunoglobulins, Intravenous, Immunologic Factors, Infant, Intensive Care Units, Pediatric, Interleukin 1 Receptor Antagonist Protein, Italy, Lymphopenia, Male, Mucocutaneous Lymph Node Syndrome, Platelet Aggregation Inhibitors, Shock, Systemic Inflammatory Response Syndrome, Tachypnea, Troponin T, Vomiting, lcsh:Diseases of the musculoskeletal system, coronary artery abnormalities, hypotension, kawasaki disease, multisystem inflammatory syndrome associated with coronavirus disease, myocarditis, pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, age distribution, antirheumatic agents, aspirin, C-reactive protein, child, preschool, coronary artery disease, cough, diarrhea, yspnea, female, glucocorticoids, heart failure, humans, hyperferritinemia, immunoglobulins, intravenous, immunologic factors, infant, intensive care units, pediatric, interleukin 1 receptor antagonist protein, italy, lymphopenia, male, mucocutaneous lymph node syndrome, platelet aggregation inhibitors, shock, systemic inflammatory response syndrome, tachypnea, troponin T, vomiting, Myocarditi, 030204 cardiovascular system & hematology, SARS-CoV-2, Kawasaki disease, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, Myocarditis, Hypotension, Multisystem inflammatory syndrome associated with coronavirus disease, Coronary artery abnormalities, Coronary artery disease, Settore MED/38 - Pediatria Generale E Specialistica, 0302 clinical medicine, Glucocorticoid, Immunologic Factor, Immunology and Allergy, Coronary artery abnormalitie, Fisher's exact test, Pediatric, biology, lcsh:RJ1-570, Antirheumatic Agent, Settore MED/38, Intensive Care Units, Cohort, symbols, Platelet aggregation inhibitor, Intravenous, Human, Research Article, medicine.medical_specialty, Immunoglobulins, 03 medical and health sciences, symbols.namesake, Rheumatology, Internal medicine, medicine, Preschool, 030203 arthritis & rheumatology, business.industry, Platelet Aggregation Inhibitor, lcsh:Pediatrics, medicine.disease, Systemic inflammatory response syndrome, Immunoglobulins, Intravenou, Pediatrics, Perinatology and Child Health, biology.protein, lcsh:RC925-935, business
Abstract

Background There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group – KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clinical, laboratory data, treatment information, and patients’ outcome were collected in an online anonymized database (RedCAP®). Relationship between clinical presentation and SARS-CoV-2 infection was also taken into account. Moreover, clinical characteristics of KDG during SARS-CoV-2 epidemic (KDG-CoV2) were compared to Kawasaki Disease patients (KDG-Historical) seen in three different Italian tertiary pediatric hospitals (Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste; AOU Meyer, Florence; IRCCS Istituto Giannina Gaslini, Genoa) from January 1st 2000 to December 31st 2019. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups. Results One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis. 37,8% of patients among KCG presented hypotension/non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated ferritin and troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and acetylsalicylic acid (ASA) (81,3% vs 66%; p = 0.04 and 71,9% vs 43,4%; p = 0.001 respectively) as KCG more often received glucocorticoids (56,6% vs 14,6%; p Conclusion Our study suggests that SARS-CoV-2 infection might determine two distinct inflammatory diseases in children: KD and PIMS-TS. Older age at onset and clinical peculiarities like the occurrence of myocarditis characterize this multi-inflammatory syndrome. Our patients had an optimal response to treatments and a good outcome, with few complications and no deaths.

Published
2020

37. Treatment of Multisystem Inflammatory Syndrome in Children

Author

McArdle A. J., Vito O., Patel H., Seaby E. G., Shah P., Wilson C., Broderick C., Nijman R., Tremoulet A. H., Munblit D., Ulloa-Gutierrez R., Carter M. J., De T., Hoggart C., Whittaker E., Herberg J. A., Kaforou M., Cunnington A. J., Levin M., Vazquez J. A., Carmona R., Perez L., Rubinos M., Veliz N., Yori S., Haerynck F., Hoste L., Leal I. A., Da Silva A. R. A., Silva A. E. A., Barchik A., Barreiro S. T. A., Cochrane N., Teixeira C. H., Arauj J. M., Ossa R. A. P. -D. L., Vieira C. S., Dimitrova A., Ganeva M., Stefanov S., Telcharova-Mihaylovska A., Biggs C. M., Scuccimarri R., Withington D., Raul B. B., Ampuero C., Aravena J., Casanova D., Cruces P., Diaz F., Garcia-Salum T., Godoy L., Medina R. A., Galaz G. V., Avila-Aguero M. L., Brenes-Chacon H., Ivankovich-Escoto G., Yock-Corrales A., Badib A., Badreldin K., Elkhashab Y., Heshmat H., Heinonen S., Angoulvant F., Belot A., Ouldali N., Beske F., Heep A., Masjosthusmann K., Reiter K., Heuvel I. V. D., Both U. V., Agrafiotou A., Antachopoulos C., Eleftheriou I., Farmaki E., Fotis L., Kafetzis D., Lampidi S., Liakopoulou T., Maritsi D., Michailidou E., Milioudi M., Mparmpounaki I., Papadimitriou E., Papaevangelou V., Roilides E., Tsiatsiou O., Tsolas G., Tsolia M., Vantsi P., Pineda L. Y. B., Aguilar K. L. B., Quintero E. M. C., Ip P., Kwan M. Y. W., Kwok J., Lau Y. L., To K., Wong J. S. C., David M., Farkas D., Kalcakosz S., Szekeres K., Zsigmond B., Aslam N., Andreozzi L., Bianco F., Bucciarelli V., Buonsenso D., Cimaz R., D'Argenio P., Dellepiane R. M., Fabi M., Mastrolia M. V., Mauro A., Mazza A., Romani L., Simonini G., Tipo V., Valentini P., Verdoni L., Reel B., Pace D., Torpiano P., Flores M. F., Dominguez M. G., Vargas A. L. G., Hernandez L. L., Figueroa R. P. M., Gaxiola G. P., Valadez J., Klevberg S., Knudsen P. K., Maseide P. H., Carrera J. M., Castano E. G., Timana C. A. D., Leon T. D., Estripeaut D., Levy J., Norero X., Record J., Rojas-Bonilla M., Iramain R., Hernandez R., Huaman G., Munaico M., Peralta C., Seminario D., Yarleque E. H. Z., Gadzinska J., Mandziuk J., Okarska-Napierala M., Alacheva Z. A., Alexeeva E., Ananin P. V., Antsupova M., Bakradze M. D., Bobkova P., Borzakova S., Chashchina I. L., Fisenko A. P., Gautier M. S., Glazyrina A., Kondrikova E., Korobyants E., Korsunskiy A. A., Kovygina K., Krasnaya E., Kurbanova S., Kurdup M. K., Mamutova A. V., Mazankova L., Mitushin I. L., Nargizyan A., Orlova Y. O., Osmanov I. M., Polyakova A. S., Romanova O., Samitova E., Sologub A., Spiridonova E., Tepaev R. F., Tkacheva A. A., Yusupova V., Zholobova E., Grasa C. D., Segura N. L., Martinon-Torres F., Melendo S., Echevarria A. M., Guzman J. M. M., Argueta J. R. P., Rivero-Calle I., Riviere J., Rodriguez-Gonzalez M., Rojo P., Manubens J. S., Soler-Palacin P., Soriano-Arandes A., Tagarro A., Villaverde S., Altman M., Brodin P., Horne A., Palmblad K., Brotschi B., Sauteur P. M., Schmid J. P., Prader S., Relly C., Schlapbach L. J., Seiler M., Truck J., Wutz D., Ketharanathan N., Vermont C., Ozkan E. A., Erdeniz E. H., Borisova G., Boychenko L., Diudenko N., Kasiyan O., Katerynych K., Melnyk K., Miagka N., Teslenko M., Trykosh M., Volokha A., Akomolafe T., Al-Abadi E., Alders N., Avram P., Bamford A., Bank M., Roy R. B., Beattie T., Boleti O., Broad J., Carrol E. D., Chandran A., Cooper H., Davies P., Emonts M., Evans C., Fidler K., Foster C., Gong C., Gongrun B., Gonzalez C., Grandjean L., Grant K., Hacohen Y., Hall J., Hassell J., Hesketh C., Hewlett J., Hnieno A., Holt-Davis H., Hossain A., Hudson L. D., Johnson M., Johnson S., Jyothish D., Kampmann B., Kavirayani A., Kelly D., Kucera F., Langer D., Lillie J., Longbottom K., Lyall H., MacKdermott N., Maltby S., McLelland T., McMahon A. -M., Miller D., Morrison Z., Mosha K., Muller J., Myttaraki E., Nadel S., Osaghae D., Osman F., Ostrzewska A., Panthula M., Papachatzi E., Papadopoulou C., Penner J., Polandi S., Prendergast A. J., Ramnarayan P., Rhys-Evans S., Riordan A., Rodrigues C. M. C., Romaine S., Seddon J., Shingadia D., Srivastava A., Struik S., Taylor A., Tran S., Tudor-Williams G., Van Der Velden F., Ventilacion L., Wellman P. A., Yanney M. P., Yeung S., Badheka A., Badran S., Bailey D. M., Burch A. K., Burns J. C., Cichon C., Cirks B., Dallman M. D., Delany D. R., Fairchok M., Friedman S., Geracht J., Langs-Barlow A., Mann K., Padhye A., Quade A., Ramirez K. A., Rockett J., Sayed I. A., Shahin A. A., Umaru S., Widener R., Angela M. H., Kandawasvika G., McArdle A.J., Vito O., Patel H., Seaby E.G., Shah P., Wilson C., Broderick C., Nijman R., Tremoulet A.H., Munblit D., Ulloa-Gutierrez R., Carter M.J., De T., Hoggart C., Whittaker E., Herberg J.A., Kaforou M., Cunnington A.J., Levin M., Vazquez J.A., Carmona R., Perez L., Rubinos M., Veliz N., Yori S., Haerynck F., Hoste L., Leal I.A., Da Silva A.R.A., Silva A.E.A., Barchik A., Barreiro S.T.A., Cochrane N., Teixeira C.H., Arauj J.M., Ossa R.A.P.-D.L., Vieira C.S., Dimitrova A., Ganeva M., Stefanov S., Telcharova-Mihaylovska A., Biggs C.M., Scuccimarri R., Withington D., Raul B.B., Ampuero C., Aravena J., Casanova D., Cruces P., Diaz F., Garcia-Salum T., Godoy L., Medina R.A., Galaz G.V., Avila-Aguero M.L., Brenes-Chacon H., Ivankovich-Escoto G., Yock-Corrales A., Badib A., Badreldin K., Elkhashab Y., Heshmat H., Heinonen S., Angoulvant F., Belot A., Ouldali N., Beske F., Heep A., Masjosthusmann K., Reiter K., Heuvel I.V.D., Both U.V., Agrafiotou A., Antachopoulos C., Eleftheriou I., Farmaki E., Fotis L., Kafetzis D., Lampidi S., Liakopoulou T., Maritsi D., Michailidou E., Milioudi M., Mparmpounaki I., Papadimitriou E., Papaevangelou V., Roilides E., Tsiatsiou O., Tsolas G., Tsolia M., Vantsi P., Pineda L.Y.B., Aguilar K.L.B., Quintero E.M.C., Ip P., Kwan M.Y.W., Kwok J., Lau Y.L., To K., Wong J.S.C., David M., Farkas D., Kalcakosz S., Szekeres K., Zsigmond B., Aslam N., Andreozzi L., Bianco F., Bucciarelli V., Buonsenso D., Cimaz R., D'Argenio P., Dellepiane R.M., Fabi M., Mastrolia M.V., Mauro A., Mazza A., Romani L., Simonini G., Tipo V., Valentini P., Verdoni L., Reel B., Pace D., Torpiano P., Flores M.F., Dominguez M.G., Vargas A.L.G., Hernandez L.L., Figueroa R.P.M., Gaxiola G.P., Valadez J., Klevberg S., Knudsen P.K., Maseide P.H., Carrera J.M., Castano E.G., Timana C.A.D., Leon T.D., Estripeaut D., Levy J., Norero X., Record J., Rojas-Bonilla M., Iramain R., Hernandez R., Huaman G., Munaico M., Peralta C., Seminario D., Yarleque E.H.Z., Gadzinska J., Mandziuk J., Okarska-Napierala M., Alacheva Z.A., Alexeeva E., Ananin P.V., Antsupova M., Bakradze M.D., Bobkova P., Borzakova S., Chashchina I.L., Fisenko A.P., Gautier M.S., Glazyrina A., Kondrikova E., Korobyants E., Korsunskiy A.A., Kovygina K., Krasnaya E., Kurbanova S., Kurdup M.K., Mamutova A.V., Mazankova L., Mitushin I.L., Nargizyan A., Orlova Y.O., Osmanov I.M., Polyakova A.S., Romanova O., Samitova E., Sologub A., Spiridonova E., Tepaev R.F., Tkacheva A.A., Yusupova V., Zholobova E., Grasa C.D., Segura N.L., Martinon-Torres F., Melendo S., Echevarria A.M., Guzman J.M.M., Argueta J.R.P., Rivero-Calle I., Riviere J., Rodriguez-Gonzalez M., Rojo P., Manubens J.S., Soler-Palacin P., Soriano-Arandes A., Tagarro A., Villaverde S., Altman M., Brodin P., Horne A., Palmblad K., Brotschi B., Sauteur P.M., Schmid J.P., Prader S., Relly C., Schlapbach L.J., Seiler M., Truck J., Wutz D., Ketharanathan N., Vermont C., Ozkan E.A., Erdeniz E.H., Borisova G., Boychenko L., Diudenko N., Kasiyan O., Katerynych K., Melnyk K., Miagka N., Teslenko M., Trykosh M., Volokha A., Akomolafe T., Al-Abadi E., Alders N., Avram P., Bamford A., Bank M., Roy R.B., Beattie T., Boleti O., Broad J., Carrol E.D., Chandran A., Cooper H., Davies P., Emonts M., Evans C., Fidler K., Foster C., Gong C., Gongrun B., Gonzalez C., Grandjean L., Grant K., Hacohen Y., Hall J., Hassell J., Hesketh C., Hewlett J., Hnieno A., Holt-Davis H., Hossain A., Hudson L.D., Johnson M., Johnson S., Jyothish D., Kampmann B., Kavirayani A., Kelly D., Kucera F., Langer D., Lillie J., Longbottom K., Lyall H., MacKdermott N., Maltby S., McLelland T., McMahon A.-M., Miller D., Morrison Z., Mosha K., Muller J., Myttaraki E., Nadel S., Osaghae D., Osman F., Ostrzewska A., Panthula M., Papachatzi E., Papadopoulou C., Penner J., Polandi S., Prendergast A.J., Ramnarayan P., Rhys-Evans S., Riordan A., Rodrigues C.M.C., Romaine S., Seddon J., Shingadia D., Srivastava A., Struik S., Taylor A., Tran S., Tudor-Williams G., Van Der Velden F., Ventilacion L., Wellman P.A., Yanney M.P., Yeung S., Badheka A., Badran S., Bailey D.M., Burch A.K., Burns J.C., Cichon C., Cirks B., Dallman M.D., Delany D.R., Fairchok M., Friedman S., Geracht J., Langs-Barlow A., Mann K., Padhye A., Quade A., Ramirez K.A., Rockett J., Sayed I.A., Shahin A.A., Umaru S., Widener R., Angela M.H., Kandawasvika G., Pediatric Surgery, Pediatrics, University of Zurich, National Institute of Health and Medical Research, Wellcome Trust, Medical Research Foundation, Shah, Priyen [0000-0001-9164-8862], Ulloa-Gutierrez, Rolando [0000-0002-9157-9227], Herberg, Jethro A [0000-0001-6941-6491], Cunnington, Aubrey J [0000-0002-1305-3529], Levin, Michael [0000-0003-2767-6919], and Apollo - University of Cambridge Repository

Subjects
Inotrope, Male, medicine.medical_treatment, 2700 General Medicine, 030204 cardiovascular system & hematology, Antibodies, Viral, Medical and Health Sciences, Cohort Studies, 0302 clinical medicine, Glucocorticoid, hemic and lymphatic diseases, Medicine and Health Sciences, 030212 general & internal medicine, Viral, Child, 11 Medical and Health Sciences, OUTCOMES, Respiration, Immunoglobulins, Intravenous, General Medicine, Systemic Inflammatory Response Syndrome, 3. Good health, Hospitalization, Treatment Outcome, Child, Preschool, Combination, Artificial, Regression Analysis, Drug Therapy, Combination, Female, Original Article, Intravenous, Life Sciences & Biomedicine, Cohort study, Human, medicine.medical_specialty, BATS Consortium, Adolescent, Immunoglobulins, 610 Medicine & health, Regression Analysi, Antibodies, Immunomodulation, 03 medical and health sciences, Medicine, General & Internal, Pharmacotherapy, Drug Therapy, Clinical Research, Internal medicine, General & Internal Medicine, medicine, MANAGEMENT, Confidence Intervals, Humans, Preschool, Propensity Score, Glucocorticoids, Mechanical ventilation, Science & Technology, business.industry, SARS-CoV-2, Inflammatory and immune system, COVID-19, Odds ratio, medicine.disease, Respiration, Artificial, Confidence interval, KAWASAKI-LIKE DISEASE, COVID-19 Drug Treatment, Systemic inflammatory response syndrome, 10036 Medical Clinic, Immunoglobulins, Intravenou, Propensity score matching, Cohort Studie, business, ACUTE RESPIRATORY SYNDROME, Confidence Interval, TOXIC-SHOCK-SYNDROME
Abstract

BackgroundEvidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2.MethodsWe performed an international observational cohort study of clinical and outcome data regarding suspected MIS-C that had been uploaded by physicians onto a Web-based database. We used inverse-probability weighting and generalized linear models to evaluate intravenous immune globulin (IVIG) as a reference, as compared with IVIG plus glucocorticoids and glucocorticoids alone. There were two primary outcomes: the first was a composite of inotropic support or mechanical ventilation by day 2 or later or death; the second was a reduction in disease severity on an ordinal scale by day 2. Secondary outcomes included treatment escalation and the time until a reduction in organ failure and inflammation.ResultsData were available regarding the course of treatment for 614 children from 32 countries from June 2020 through February 2021; 490 met the World Health Organization criteria for MIS-C. Of the 614 children with suspected MIS-C, 246 received primary treatment with IVIG alone, 208 with IVIG plus glucocorticoids, and 99 with glucocorticoids alone; 22 children received other treatment combinations, including biologic agents, and 39 received no immunomodulatory therapy. Receipt of inotropic or ventilatory support or death occurred in 56 patients who received IVIG plus glucocorticoids (adjusted odds ratio for the comparison with IVIG alone, 0.77; 95% confidence interval [CI], 0.33 to 1.82) and in 17 patients who received glucocorticoids alone (adjusted odds ratio, 0.54; 95% CI, 0.22 to 1.33). The adjusted odds ratios for a reduction in disease severity were similar in the two groups, as compared with IVIG alone (0.90 for IVIG plus glucocorticoids and 0.93 for glucocorticoids alone). The time until a reduction in disease severity was similar in the three groups.ConclusionsWe found no evidence that recovery from MIS-C differed after primary treatment with IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone, although significant differences may emerge as more data accrue. (Funded by the European Union's Horizon 2020 Program and others; BATS ISRCTN number, ISRCTN69546370.).

Published
2021

38. Temporal clustering of Kawasaki disease cases around the world

Author

Burney J. A., DeHaan L. L., Shimizu C., Bainto E. V., Newburger J. W., DeBiasi R. L., Dominguez S. R., Portman M. A., Melish M., Bratincsak A., Fabi M., Corinaldesi E., Yu J. J., Gee P., Kitano N., Tremoulet A. H., Cayan D. R., Burns J. C., Ansusinha E., Jone P. -N., Hite M., Heizer H. R., Anderson M. S., Pavan V., Andreozzi L., Gee W., Suzuki H., Burney J.A., DeHaan L.L., Shimizu C., Bainto E.V., Newburger J.W., DeBiasi R.L., Dominguez S.R., Portman M.A., Melish M., Bratincsak A., Fabi M., Corinaldesi E., Yu J.J., Gee P., Kitano N., Tremoulet A.H., Cayan D.R., Burns J.C., Ansusinha E., Jone P.-N., Hite M., Heizer H.R., Anderson M.S., Pavan V., Andreozzi L., Gee W., and Suzuki H.

Subjects
Temporal clustering, Time Factors, Range (biology), Epidemiology, Science, Cardiology, Mucocutaneous Lymph Node Syndrome, Global Health, Article, Kawasaki disease, vasculitis, children, cluster, seasonality, epidemiology, multifactorial diseases, etiology, Republic of Korea, medicine, Cluster Analysis, Humans, Child, Multidisciplinary, Incidence, Kawasaki Disease Climate Study Group, Seasonality, medicine.disease, Disease etiology, Hospitals, United States, Geography, Italy, Linear Models, Medicine, Kawasaki disease, Cartography, Monte Carlo Method, New Zealand
Abstract

In a single-site study (San Diego, CA, USA), we previously showed that Kawasaki Disease (KD) cases cluster temporally in bursts of approximately 7 days. These clusters occurred more often than would be expected at random even after accounting for long-term trends and seasonality. This finding raised the question of whether other locations around the world experience similar temporal clusters of KD that might offer clues to disease etiology. Here we combine data from San Diego and nine additional sites around the world with hospitals that care for large numbers of KD patients, as well as two multi-hospital catchment regions. We found that across these sites, KD cases clustered at short time scales and there were anomalously long quiet periods with no cases. Both of these phenomena occurred more often than would be expected given local trends and seasonality. Additionally, we found unusually frequent temporal overlaps of KD clusters and quiet periods between pairs of sites. These findings suggest that regional and planetary range environmental influences create periods of higher or lower exposure to KD triggers that may offer clues to the etiology of KD.

Published
2021

39. Cosmic-ray flux predictions and observations for and with Metis on board Solar Orbiter

Author

Grimani, C., primary, Andretta, V., additional, Chioetto, P., additional, Da Deppo, V., additional, Fabi, M., additional, Gissot, S., additional, Naletto, G., additional, Persici, A., additional, Plainaki, C., additional, Romoli, M., additional, Sabbatini, F., additional, Spadaro, D., additional, Stangalini, M., additional, Telloni, D., additional, Uslenghi, M., additional, Antonucci, E., additional, Bemporad, A., additional, Capobianco, G., additional, Capuano, G., additional, Casti, M., additional, De Leo, Y., additional, Fineschi, S., additional, Frassati, F., additional, Frassetto, F., additional, Heinzel, P., additional, Jerse, G., additional, Landini, F., additional, Liberatore, A., additional, Magli, E., additional, Messerotti, M., additional, Moses, D., additional, Nicolini, G., additional, Pancrazzi, M., additional, Pelizzo, M. G., additional, Romano, P., additional, Sasso, C., additional, Schühle, U., additional, Slemer, A., additional, Straus, T., additional, Susino, R., additional, Teriaca, L., additional, Volpicelli, C. A., additional, Freiherr von Forstner, J. L., additional, and Zuppella, P., additional

Published
2021
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40. First light observations of the solar wind in the outer corona with the Metis coronagraph

Author

Romoli, M., primary, Antonucci, E., additional, Andretta, V., additional, Capuano, G. E., additional, Da Deppo, V., additional, De Leo, Y., additional, Downs, C., additional, Fineschi, S., additional, Heinzel, P., additional, Landini, F., additional, Liberatore, A., additional, Naletto, G., additional, Nicolini, G., additional, Pancrazzi, M., additional, Sasso, C., additional, Spadaro, D., additional, Susino, R., additional, Telloni, D., additional, Teriaca, L., additional, Uslenghi, M., additional, Wang, Y.-M., additional, Bemporad, A., additional, Capobianco, G., additional, Casti, M., additional, Fabi, M., additional, Frassati, F., additional, Frassetto, F., additional, Giordano, S., additional, Grimani, C., additional, Jerse, G., additional, Magli, E., additional, Massone, G., additional, Messerotti, M., additional, Moses, D., additional, Pelizzo, M.-G., additional, Romano, P., additional, Schühle, U., additional, Slemer, A., additional, Stangalini, M., additional, Straus, T., additional, Volpicelli, C. A., additional, Zangrilli, L., additional, Zuppella, P., additional, Abbo, L., additional, Auchère, F., additional, Aznar Cuadrado, R., additional, Berlicki, A., additional, Bruno, R., additional, Ciaravella, A., additional, D’Amicis, R., additional, Lamy, P., additional, Lanzafame, A., additional, Malvezzi, A. M., additional, Nicolosi, P., additional, Nisticò, G., additional, Peter, H., additional, Plainaki, C., additional, Poletto, L., additional, Reale, F., additional, Solanki, S. K., additional, Strachan, L., additional, Tondello, G., additional, Tsinganos, K., additional, Velli, M., additional, Ventura, R., additional, Vial, J.-C., additional, Woch, J., additional, and Zimbardo, G., additional

Published
2021
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41. The first coronal mass ejection observed in both visible-light and UV H I Ly-αchannels of the Metis coronagraph on board Solar Orbiter

Author

Andretta, V., primary, Bemporad, A., additional, De Leo, Y., additional, Jerse, G., additional, Landini, F., additional, Mierla, M., additional, Naletto, G., additional, Romoli, M., additional, Sasso, C., additional, Slemer, A., additional, Spadaro, D., additional, Susino, R., additional, Talpeanu, D.-C., additional, Telloni, D., additional, Teriaca, L., additional, Uslenghi, M., additional, Antonucci, E., additional, Auchère, F., additional, Berghmans, D., additional, Berlicki, A., additional, Capobianco, G., additional, Capuano, G. E., additional, Casini, C., additional, Casti, M., additional, Chioetto, P., additional, Da Deppo, V., additional, Fabi, M., additional, Fineschi, S., additional, Frassati, F., additional, Frassetto, F., additional, Giordano, S., additional, Grimani, C., additional, Heinzel, P., additional, Liberatore, A., additional, Magli, E., additional, Massone, G., additional, Messerotti, M., additional, Moses, D., additional, Nicolini, G., additional, Pancrazzi, M., additional, Pelizzo, M.-G., additional, Romano, P., additional, Schühle, U., additional, Stangalini, M., additional, Straus, Th., additional, Volpicelli, C. A., additional, Zangrilli, L., additional, Zuppella, P., additional, Abbo, L., additional, Aznar Cuadrado, R., additional, Bruno, R., additional, Ciaravella, A., additional, D’Amicis, R., additional, Lamy, P., additional, Lanzafame, A., additional, Malvezzi, A. M., additional, Nicolosi, P., additional, Nisticò, G., additional, Peter, H., additional, Plainaki, C., additional, Poletto, L., additional, Reale, F., additional, Solanki, S. K., additional, Strachan, L., additional, Tondello, G., additional, Tsinganos, K., additional, Velli, M., additional, Ventura, R., additional, Vial, J.-C., additional, Woch, J., additional, and Zimbardo, G., additional

Published
2021
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42. In-flight optical performance assessment for the Metis solar coronagraph

Author

Deppo, V. D., Chioetto, P., Andretta, V., Casini, C., Frassetto, F., Slemer, A., Zuppella, P., Romoli, M., Fineschi, S., Heinzel, P., Naletto, G., Nicolini, G., Spadaro, D., Stangalini, M., Teriaca, L., Bemporad, A., Casti, M., de Leo, Y., Fabi, M., Grimani, C., Heerlein, K., Jerse, G., Landini, F., Liberatore, A., Magli, E., Melich, R., Pancrazzi, M., Pelizzo, M. G., Romano, P., Sasso, C., Straus, T., Susino, R., Uslenghi, M., and Volpicelli, C. A.

Subjects
Metis coronagraph, Optical performance, PSF, Solar Orbiter mission, Vignetting, Computer science, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Corona, law.invention, Telescope, Orbiter, Optics, law, Metis, Calibration, Astrophysics::Solar and Stellar Astrophysics, Focal length, business, Coronagraph
Abstract

Metis is a multi-wavelength coronagraph onboard the European Space Agency (ESA) Solar Orbiter mission. The instrument features an innovative instrument design conceived for simultaneously imaging the Sun's corona in the visible and ultraviolet range. The Metis visible channel employs broad-band, polarized imaging of the visible K-corona, while the UV one uses narrow-band imaging at the HI Ly 􀄮, i.e. 121.6 nm. During the commissioning different acquisitions and activities, performed with both the Metis channels, have been carried out with the aim to check the functioning and the performance of the instrument. In particular, specific observations of stars have been devised to assess the optical alignment of the telescope and to derive the instrument optical parameters such as focal length, PSF and possibly check the optical distortion and the vignetting function. In this paper, the preliminary results obtained for the PSF of both channels and the determination of the scale for the visible channel will be described and discussed. The in-flight obtained data will be compared to those obtained on-ground during the calibration campaign.

Published
2021
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44. First-light Observations of the Metis Solar Coronagraph

Author

Fineschi, S., Romoli, M., Andretta, V., Bemporad, A., Capobianco, G., Casti, M., da Deppo, V., de Leo, Y., Fabi, M., Frassetto, F., Grimani, C., Heerlein, K., Heinzel, P., Jerse, G., Landini, F., Liberatore, A., Magli, E., Naletto, G., Nicolini, G., Pancrazzi, M., Pelizzo, M. G., Romano, P., Sasso, C., Slemer, A., Spadaro, D., Stangalini, M., Straus, T., Susino, R., Teriaca, L., Uslenghi, M., Volpicelli, C. A., and Zuppella, P.

Subjects
Coronagraph, Electron density, Metis, Polarization, Solar corona, Solar Orbiter, Sun
Published
2021

45. The first coronal mass ejection observed in both visible-light and UV H I Ly-alpha channels of the Metis coronagraph on board Solar Orbiter

Author

Andretta, V Bemporad, A. De Leo, Y. Jerse, G. Landini, F. Mierla, M. Naletto, G. Romoli, M. Sasso, C. and Slemer, A. Spadaro, D. Susino, R. Talpeanu, D-C Telloni, D. Teriaca, L. Uslenghi, M. Antonucci, E. Auchere, F. and Berghmans, D. Berlicki, A. Capobianco, G. Capuano, G. E. and Casini, C. Casti, M. Chioetto, P. Da Deppo, V Fabi, M. Fineschi, S. Frassati, F. Frassetto, F. Giordano, S. and Grimani, C. Heinzel, P. Liberatore, A. Magli, E. and Massone, G. Messerotti, M. Moses, D. Nicolini, G. and Pancrazzi, M. Pelizzo, M-G Romano, P. Schuehle, U. and Stangalini, M. Straus, Th Volpicelli, C. A. Zangrilli, L. and Zuppella, P. Abbo, L. Cuadrado, R. Aznar Bruno, R. and Ciaravella, A. D'Amicis, R. Lamy, P. Lanzafame, A. and Malvezzi, A. M. Nicolosi, P. Nistico, G. Peter, H. and Plainaki, C. Poletto, L. Reale, F. Solanki, S. K. and Strachan, L. Tondello, G. Tsinganos, K. Velli, M. and Ventura, R. Vial, J-C Woch, J. Zimbardo, G.

Abstract

Context. The Metis coronagraph on board Solar Orbiter offers a new view of coronal mass ejections (CMEs), observing them for the first time with simultaneous images acquired with a broad-band filter in the visible-light interval and with a narrow-band filter around the H I Ly-alpha line at 121.567 nm, the so-called Metis UV channel. Aims. We show the first Metis observations of a CME, obtained on 16 and 17 January 2021. The event was also observed by the EUI/FSI imager on board Solar Orbiter, as well as by other space-based coronagraphs, such as STEREO-A/COR2 and SOHO/LASCO/C2, whose images are combined here with Metis data. Methods. Different images are analysed here to reconstruct the 3D orientation of the expanding CME flux rope using the graduated cylindrical shell model. This also allows us to identify the possible location of the source region. Measurements of the CME kinematics allow us to quantify the expected Doppler dimming in the Ly-alpha channel. Results. Observations show that most CME features seen in the visible-light images are also seen in the Ly-alpha images, although some features in the latter channel appear more structured than their visible-light counterparts. We estimated the expansion velocity of this event to be below 140 km s(-1). Hence, these observations can be understood by assuming that Doppler dimming effects do not strongly reduce the Ly-alpha emission from the CME. These velocities are comparable with or smaller than the radial velocities inferred from the same data in a similar coronal structure on the east side of the Sun. Conclusions. The first observations by Metis of a CME demonstrate the capability of the instrument to provide valuable and novel information on the structure and dynamics of these coronal events. Considering also its diagnostics capabilities regarding the conditions of the ambient corona, Metis promises to significantly advance our knowledge of such phenomena.

Published
2021

46. Treatment of Multisystem Inflammatory Syndrome in Children

Author

McArdle, A.J. Vito, O. Patel, H. Seaby, E.G. Shah, P. Wilson, C. Broderick, C. Nijman, R. Tremoulet, A.H. Munblit, D. Ulloa-Gutierrez, R. Carter, M.J. De, T. Hoggart, C. Whittaker, E. Herberg, J.A. Kaforou, M. Cunnington, A.J. Levin, M. Vazquez, J.A. Carmona, R. Perez, L. Rubinos, M. Veliz, N. Yori, S. Haerynck, F. Hoste, L. Leal, I.A. Da Silva, A.R.A. Silva, A.E.A. Barchik, A. Barreiro, S.T.A. Cochrane, N. Teixeira, C.H. Arauj, J.M. Ossa, R.A.P.-D.L. Vieira, C.S. Dimitrova, A. Ganeva, M. Stefanov, S. Telcharova-Mihaylovska, A. Biggs, C.M. Scuccimarri, R. Withington, D. Raul, B.B. Ampuero, C. Aravena, J. Casanova, D. Cruces, P. Diaz, F. Garcia-Salum, T. Godoy, L. Medina, R.A. Galaz, G.V. Avila-Aguero, M.L. Brenes-Chacon, H. Ivankovich-Escoto, G. Yock-Corrales, A. Badib, A. Badreldin, K. Elkhashab, Y. Heshmat, H. Heinonen, S. Angoulvant, F. Belot, A. Ouldali, N. Beske, F. Heep, A. Masjosthusmann, K. Reiter, K. Heuvel, I.V.D. Both, U.V. Agrafiotou, A. Antachopoulos, C. Eleftheriou, I. Farmaki, E. Fotis, L. Kafetzis, D. Lampidi, S. Liakopoulou, T. Maritsi, D. Michailidou, E. Milioudi, M. Mparmpounaki, I. Papadimitriou, E. Papaevangelou, V. Roilides, E. Tsiatsiou, O. Tsolas, G. Tsolia, M. Vantsi, P. Pineda, L.Y.B. Aguilar, K.L.B. Quintero, E.M.C. Ip, P. Kwan, M.Y.W. Kwok, J. Lau, Y.L. To, K. Wong, J.S.C. David, M. Farkas, D. Kalcakosz, S. Szekeres, K. Zsigmond, B. Aslam, N. Andreozzi, L. Bianco, F. Bucciarelli, V. Buonsenso, D. Cimaz, R. D'Argenio, P. Dellepiane, R.M. Fabi, M. Mastrolia, M.V. Mauro, A. Mazza, A. Romani, L. Simonini, G. Tipo, V. Valentini, P. Verdoni, L. Reel, B. Pace, D. Torpiano, P. Flores, M.F. Domínguez, M.G. Vargas, A.L.G. Hernandez, L.L. Figueroa, R.P.M. Gaxiola, G.P. Valadez, J. Klevberg, S. Knudsen, P.K. Maseide, P.H. Carrera, J.M. Castano, E.G. Timana, C.A.D. Leon, T.D. Estripeaut, D. Levy, J. Norero, X. Record, J. Rojas-Bonilla, M. Iramain, R. Hernandez, R. Huaman, G. Munaico, M. Peralta, C. Seminario, D. Yarleque, E.H.Z. Gadzinska, J. Mandziuk, J. Okarska-Napierała, M. Alacheva, Z.A. Alexeeva, E. Ananin, P.V. Antsupova, M. Bakradze, M.D. Bobkova, P. Borzakova, S. Chashchina, I.L. Fisenko, A.P. Gautier, M.S. Glazyrina, A. Kondrikova, E. Korobyants, E. Korsunskiy, A.A. Kovygina, K. Krasnaya, E. Kurbanova, S. Kurdup, M.K. Mamutova, A.V. Mazankova, L. Mitushin, I.L. Nargizyan, A. Orlova, Y.O. Osmanov, I.M. Polyakova, A.S. Romanova, O. Samitova, E. Sologub, A. Spiridonova, E. Tepaev, R.F. Tkacheva, A.A. Yusupova, V. Zholobova, E. Grasa, C.D. Segura, N.L. Martinon-Torres, F. Melendo, S. Echevarria, A.M. Guzman, J.M.M. Argueta, J.R.P. Rivero-Calle, I. Riviere, J. Rodriguez-Gonzalez, M. Rojo, P. Manubens, J.S. Soler-Palacin, P. Soriano-Arandes, A. Tagarro, A. Villaverde, S. Altman, M. Brodin, P. Horne, A. Palmblad, K. Brotschi, B. Sauteur, P.M. Schmid, J.P. Prader, S. Relly, C. Schlapbach, L.J. Seiler, M. Truck, J. Wutz, D. Ketharanathan, N. Vermont, C. Ozkan, E.A. Erdeniz, E.H. Borisova, G. Boychenko, L. Diudenko, N. Kasiyan, O. Katerynych, K. Melnyk, K. Miagka, N. Teslenko, M. Trykosh, M. Volokha, A. Akomolafe, T. Al-Abadi, E. Alders, N. Avram, P. Bamford, A. Bank, M. Roy, R.B. Beattie, T. Boleti, O. Broad, J. Carrol, E.D. Chandran, A. Cooper, H. Davies, P. Emonts, M. Evans, C. Fidler, K. Foster, C. Gong, C. Gongrun, B. Gonzalez, C. Grandjean, L. Grant, K. Hacohen, Y. Hall, J. Hassell, J. Hesketh, C. Hewlett, J. Hnieno, A. Holt-Davis, H. Hossain, A. Hudson, L.D. Johnson, M. Johnson, S. Jyothish, D. Kampmann, B. Kavirayani, A. Kelly, D. Kucera, F. Langer, D. Lillie, J. Longbottom, K. Lyall, H. MacKdermott, N. Maltby, S. McLelland, T. McMahon, A.-M. Miller, D. Morrison, Z. Mosha, K. Muller, J. Myttaraki, E. Nadel, S. Osaghae, D. Osman, F. Ostrzewska, A. Panthula, M. Papachatzi, E. Papadopoulou, C. Penner, J. Polandi, S. Prendergast, A.J. Ramnarayan, P. Rhys-Evans, S. Riordan, A. Rodrigues, C.M.C. Romaine, S. Seddon, J. Shingadia, D. Srivastava, A. Struik, S. Taylor, A. Taylor, A. Taylor, A. Tran, S. Tudor-Williams, G. Van Der Velden, F. Ventilacion, L. Wellman, P.A. Yanney, M.P. Yeung, S. Badheka, A. Badran, S. Bailey, D.M. Burch, A.K. Burns, J.C. Cichon, C. Cirks, B. Dallman, M.D. Delany, D.R. Fairchok, M. Friedman, S. Geracht, J. Langs-Barlow, A. Mann, K. Padhye, A. Quade, A. Ramirez, K.A. Rockett, J. Sayed, I.A. Shahin, A.A. Umaru, S. Widener, R. Angela, M.H. Kandawasvika, G. BATS Consortium

Subjects
hemic and lymphatic diseases
Abstract

BACKGROUND Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS We performed an international observational cohort study of clinical and outcome data regarding suspected MIS-C that had been uploaded by physicians onto a Web-based database. We used inverse-probability weighting and generalized linear models to evaluate intravenous immune globulin (IVIG) as a reference, as compared with IVIG plus glucocorticoids and glucocorticoids alone. There were two primary outcomes: the first was a composite of inotropic support or mechanical ventilation by day 2 or later or death; the second was a reduction in disease severity on an ordinal scale by day 2. Secondary outcomes included treatment escalation and the time until a reduction in organ failure and inflammation. RESULTS Data were available regarding the course of treatment for 614 children from 32 countries from June 2020 through February 2021; 490 met the World Health Organization criteria for MIS-C. Of the 614 children with suspected MIS-C, 246 received primary treatment with IVIG alone, 208 with IVIG plus glucocorticoids, and 99 with glucocorticoids alone; 22 children received other treatment combinations, including biologic agents, and 39 received no immunomodulatory therapy. Receipt of inotropic or ventilatory support or death occurred in 56 patients who received IVIG plus glucocorticoids (adjusted odds ratio for the comparison with IVIG alone, 0.77; 95% confidence interval [CI], 0.33 to 1.82) and in 17 patients who received glucocorticoids alone (adjusted odds ratio, 0.54; 95% CI, 0.22 to 1.33). The adjusted odds ratios for a reduction in disease severity were similar in the two groups, as compared with IVIG alone (0.90 for IVIG plus glucocorticoids and 0.93 for glucocorticoids alone). The time until a reduction in disease severity was similar in the three groups. CONCLUSIONS We found no evidence that recovery from MIS-C differed after primary treatment with IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone, although significant differences may emerge as more data accrue. Copyright © 2021 Massachusetts Medical Society.

Published
2021

47. African American Novels and the New Slavery in the New South

Author

Fabi, m. giulia

Subjects
Upton Sinclair, Ambientale, Realism, Mark Twain, Jim Crow, Charles W. Chesnutt, Sutton E. Griggs, Thomas Dixon, Upton Sinclair, Mark Twain, American fiction, African American fiction, slavery, Reconstruction, Jim Crow, Realism, Modernism, slavery, Thomas Dixon, Modernism, Sutton E. Griggs, American fiction, Reconstruction, Charles W. Chesnutt, African American fiction
Published
2021

48. Nella Larsen e Alice Walker: due classici americani ritrovati

Author

Fabi, m. giulia

Subjects
Nella Larsen, Alice Walker, passing, American literature, Ambientale, American literature, Alice Walker, African American fiction, Nella Larsen, segregation, passing, segregation, African American fiction
Published
2021

50. First light observations of the solar wind in the outer corona with the Metis coronagraph

Author

Romoli, M. Antonucci, E. Andretta, V Capuano, G. E. Da Deppo, V De Leo, Y. Downs, C. Fineschi, S. Heinzel, P. and Landini, F. Liberatore, A. Naletto, G. Nicolini, G. and Pancrazzi, M. Sasso, C. Spadaro, D. Susino, R. Telloni, D. Teriaca, L. Uslenghi, M. Wang, Y-M Bemporad, A. and Capobianco, G. Casti, M. Fabi, M. Frassati, F. and Frassetto, F. Giordano, S. Grimani, C. Jerse, G. Magli, E. Massone, G. Messerotti, M. Moses, D. Pelizzo, M-G and Romano, P. Schuehle, U. Slemer, A. Stangalini, M. and Straus, T. Volpicelli, C. A. Zangrilli, L. Zuppella, P. and Abbo, L. Auchere, F. Cuadrado, R. Aznar Berlicki, A. and Bruno, R. Ciaravella, A. D'Amicis, R. Lamy, P. and Lanzafame, A. Malvezzi, A. M. Nicolosi, P. Nistico, G. and Peter, H. Plainaki, C. Poletto, L. Reale, F. Solanki, S. K. Strachan, L. Tondello, G. Tsinganos, K. Velli, M. and Ventura, R. Vial, J-C Woch, J. Zimbardo, G.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Physics::Space Physics, Astrophysics::Solar and Stellar Astrophysics
Abstract

In this work, we present an investigation of the wind in the solar corona that has been initiated by observations of the resonantly scattered ultraviolet emission of the coronal plasma obtained with UVCS-SOHO, designed to measure the wind outflow speed by applying Doppler dimming diagnostics. Metis on Solar Orbiter complements the UVCS spectroscopic observations that were performed during solar activity cycle 23 by simultaneously imaging the polarized visible light and the H I Lyman-alpha corona in order to obtain high spatial and temporal resolution maps of the outward velocity of the continuously expanding solar atmosphere. The Metis observations, taken on May 15, 2020, provide the first H I Lyman-alpha images of the extended corona and the first instantaneous map of the speed of the coronal plasma outflows during the minimum of solar activity and allow us to identify the layer where the slow wind flow is observed. The polarized visible light (580-640 nm) and the ultraviolet H I Ly alpha (121.6 nm) coronal emissions, obtained with the two Metis channels, were combined in order to measure the dimming of the UV emission relative to a static corona. This effect is caused by the outward motion of the coronal plasma along the direction of incidence of the chromospheric photons on the coronal neutral hydrogen. The plasma outflow velocity was then derived as a function of the measured Doppler dimming. The static corona UV emission was simulated on the basis of the plasma electron density inferred from the polarized visible light. This study leads to the identification, in the velocity maps of the solar corona, of the high-density layer about +/- 10 degrees wide, centered on the extension of a quiet equatorial streamer present at the east limb - the coronal origin of the heliospheric current sheet - where the slowest wind flows at about 160 +/- 18 km s(-1) from 4 R-circle dot to 6 R-circle dot. Beyond the boundaries of the high-density layer, the wind velocity rapidly increases, marking the transition between slow and fast wind in the corona.

Published
2021

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