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Objetivo: Presentar nuestra experiencia en el manejo de infecciones micóticas de catéteres venosos centrales (CVC) de larga duración en pacientes pediátricos con enfermedades hemato-oncológicas. Material y método: Estudio retrospectivo entre Enero de 1998 y Diciembre de 1999 en el Servicio de Pediatría del Hospital Clínico Regional Valdivia. Se registraron 19 pacientes con CVC. Resultados: Ocho casos presentaron infección del catéter, 5 por Cándida. De estos últimos, todos consultaron por síndrome febril. El tiempo de permanencia del CVC fue en promedio de 208 días (rango 92 y 451 días). La tasa de infección de torrente sanguíneo por hongos asociado a 1 000 días de uso de CVC Hickman es de 1,9‰. Todos se manejaron con antifúngicos y retiro del catéter. Conclusiones: Las cándidas constituyen la causa principal de infección de catéter en el presente estudio. El adecuado manejo de esta infección es el retiro precoz del catéter asociado a una terapia antifúngica oportuna Objective: To present our experience in the management of fungal infections of central venous lines in paedriatric haematological-oncological patients. Methods: A retrospective study carried out between January 1998 and December 1999 at the Division of Pediatrics, Valdivia Hospital. Results: Of 19 children with a central venous line, 8 presented with a central line infection, of which 5 were caused by Candida. They presented with fever. The average length of catheter implantation was 208 days (range 92-451). The rate per 1 000 days for fungal infection using the Hickman line was 1.9‰. All were treated with line removal and antifungal therapy. Conclusions: Candida is the main cause of fungal line infections and the appropriate treatment is early line removal and antifungal therapy

Background: Little information is available in Chile about hepatitis C virus (HCV) in hematological and oncohematological patients. Aim: To evaluate the prevalence of hepatitis C virus markers in a group of hematological and oncohematological pediatric patients seen at Valdivia Regional Hospital. Patients and methods: Antibodies against virus C, determined by ELISA and viral RNA, determined using RT-polymerase chain reaction, were measured in 54 blood samples from children with hematological diseases (34 with Acute Lymphoblastic Leukaemia, 4 with Hodgkin Diseases, 4 with Haemolytic Anemia, 5 with Sarcomas, 2 with Non-Hodgkin Lymphoma, 2 with Thrombocytopenic Purpura, 1 with an Ependimoma, one with a Wilms Tumor and 1 with a Von Willebrand Disease). Results: All samples were negative for antibodies against hepatitis C virus. Viral RNA was found in four children, all with a diagnosis of acute lymphoblastic leukemia and who received chemotherapy and multiple transfusions. Conclusions: The prevalence of Viral RNA for hepatitis C virus in oncohematological patients in our study is high and associated with the use of chemotherapy and multiple transfusions (Rev Méd Chile 2001; 129: 18-22)