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1. Inhibition of Mammary Carcinoma 755 by Malonic Acid Derivatives

Author

B. L. Freedlander, Arthur Furst, and French Fa

Subjects
Chemistry, Stereochemistry, Mammary Neoplasms, Experimental, Breast Neoplasms, Neoplasms, Experimental, Malonic acid, Ethyl ester, medicine.disease, Inhibitory postsynaptic potential, Malonates, General Biochemistry, Genetics and Molecular Biology, Mammary carcinoma, chemistry.chemical_compound, medicine, Animals, Humans, Adenocarcinoma
Abstract

SummaryDiethyl ethoxymethylenemal-onate inhibited the growth of transplanted adenocarcinoma 755 in C57 black mice. The formyl and β-pyridylene malonic ethyl esters as well as two malonamides gave moderate inhibitory values. These compounds were inactive when tested against other transplanted tumors. Some possible modes of action are discussed.

Published
1956
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2. Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells

Author

Renata Santos, Françoise Auchère, Nicole Boggetto, Caroline Brossas, Sophie D. Lefevre, Jean-Michel Camadro, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), French Government (CNRS), the French FA Patient Organization (AFAF) the Agence Nationale de la Recherche (ANR Maladies Rares, France), Funding to pay the Open Access publication charges for this article was provided by the French FA Patient Organization (AFAF)., Ecole Doctorale Complexité du Vivant (ED515), Sorbonne Université (SU), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm - Paris Descartes), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Thermique de Lyon (CETHIL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)

Subjects
DNA Repair, [SDV]Life Sciences [q-bio], Gene Expression, Apoptosis, medicine.disease_cause, Antioxidants, AP endonuclease, Gene Expression Regulation, Fungal, Iron-Binding Proteins, DNA Breaks, Double-Stranded, Anaerobiosis, DNA, Fungal, Genetics (clinical), 0303 health sciences, 030302 biochemistry & molecular biology, Articles, General Medicine, Base excision repair, DNA repair protein XRCC4, Oxidants, Glutathione, Oxidation-Reduction, Alkylating Agents, Saccharomyces cerevisiae Proteins, DNA repair, DNA damage, Saccharomyces cerevisiae, Biology, DNA, Mitochondrial, 03 medical and health sciences, Genetics, medicine, Humans, Molecular Biology, 030304 developmental biology, Endodeoxyribonucleases, Microbial Viability, Mutagenesis, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Cell Cycle Checkpoints, Hydrogen Peroxide, Methyl Methanesulfonate, Molecular biology, Oxidative Stress, DNA Repair Enzymes, Friedreich Ataxia, Frataxin, biology.protein, Reactive Oxygen Species, Oxidative stress
Abstract

International audience; Frataxin deficiency results in mitochondrial dysfunction and oxidative stress and it is the cause of the hereditary neurodegenerative disease Friedreich ataxia (FA). Here, we present evidence that one of the pleiotropic effects of oxidative stress in frataxin-deficient yeast cells (Δyfh1 mutant) is damage to nuclear DNA and that repair requires the Apn1 AP-endonuclease of the base excision repair pathway. Major phenotypes of Δyfh1 cells are respiratory deficit, disturbed iron homeostasis and sensitivity to oxidants. These phenotypes are weak or absent under anaerobiosis. We show here that exposure of anaerobically grown Δyfh1 cells to oxygen leads to down-regulation of antioxidant defenses, increase in reactive oxygen species, delay in G1- and S-phases of the cell cycle and damage to mitochondrial and nuclear DNA. Nuclear DNA lesions in Δyfh1 cells are primarily caused by oxidized bases and single-strand breaks that can be detected 15-30 min after oxygen exposition. The Apn1 enzyme is essential for the repair of the DNA lesions in Δyfh1 cells. Compared with Δyfh1, the double Δyfh1Δapn1 mutant shows growth impairment, increased mutagenesis and extreme sensitivity to H(2)O(2). On the contrary, overexpression of the APN1 gene in Δyfh1 cells decreases spontaneous and induced mutagenesis. Our results show that frataxin deficiency in yeast cells leads to increased DNA base oxidation and requirement of Apn1 for repair, suggesting that DNA damage and repair could be important features in FA disease progression.

Published
2012
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3. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Jean-Sébastien Casalegno, Céline Monnard, Hanaa Benmansour, Stéphane Bonacorsi, Chloé Plouzeau, Agathe Becker, Guillaume Geslain, Camille d’Humières, Paul Duquaire, Catherine Neuwirth, Lauranne Broutin, Emmanuel Lecorche, Claude-Alexandre Gustave, Carole Lemarié, Laurence Armand-Lefevre, Emmanuelle Vigier, Adel Maamar, Jean-Philippe Lavigne, Jean-Pierre Quenot, Christophe Burucoa, Olivier Dauwalder, Gabriel Auger, Julie Cremniter, Alexy Tran-Dinh, Marion Baldeyrou, Hervé Jacquier, Maxime Pichon, Rafael Mahieu, Claire Poyart, Julien Loubinoux, Solen Kernéis, Manon Lejeune, Jean-François Timsit, Nabil Gastli, Bruno Lina, François Vandenesch, Achille Kouatchet, Vincent Cattoir, Pierre Saint-Sardos, Emmanuelle Cambau, Anthony Michaud, Sophie Alviset, André Boibieux, Aurélie Cointe, Gauthier Péan de Ponfilly, Grégory Destras, Robin Stéphan, Matthieu Daragon, Philippe Montravers, Michael Levy, Vincent Rzepecki, Hélène Pailhoriès, Service de Bactériologie [CHU Cochin, AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de bactériologie (CHU Dijon), Plateau technique de Biologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Service de Bactériologie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital de la Milétrie, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Robert Debré, Laboratoire de Bactériologie et Hygiène Hospitalière [Rennes], CHU Pontchaillou [Rennes], Centre National de Référence de la Résistance aux Antibiotiques [CHU Rennes] (CNR), Hôpital Cochin [AP-HP], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Meso Scale Diagnostics, The French FA-PP study group includes the following investigators: Sophie Alviset (Paris Cochin), Laurence Armand-Lefèvre (Paris Bichat), Marion Baldeyrou (Rennes), Agathe Becker (Hospices Civils de Lyon), André Boibieux (Hospices Civils de Lyon), Stéphane Bonacorsi (Paris, Robert-Debré), Christophe Burucoa (Poitiers), Emmanuelle Cambau (Paris Lariboisière), Jean-Sébastien Casalegno (Hospices Civils de Lyon), Aurélie Cointe (Paris, Robert-Debré), Julie Cremniter (Poitiers), Grégory Destras (Hospices Civils de Lyon), Paul Duquaire (Hospices Civils de Lyon), Guillaume Geslain (Paris, Robert-Debré), Claude-Alexandre Gustave (Hospices Civils de Lyon), Hervé Jacquier (Paris Lariboisière), Achille Kouatchet (Angers), Emmanuel Lecorche (Paris Lariboisière), Manon Lejeune (Paris Bichat), Bruno Lina (Hospices Civils de Lyon), Rafaël Mahieu (Angers), Adel Maamar (Rennes), Anthony Michaud (Poitiers), Céline Monnard (Hospices Civils de Lyon), Philippe Montravers (Paris Bichat), Catherine Neuwirth (Dijon), Gauthier Péan de Ponfilly (Paris, Lariboisière), Maxime Pichon (Poitiers), Chloé Plouzeau (Poitiers), Claire Poyart (Paris Cochin), Jean-Pierre Quenot (Dijon), Vincent Rzepecki (Nîmes), Robin Stéphan (Nîmes), Jean-François Timsit (Paris Bichat), Alexy Tran-Dinh (Paris Bichat), François Vandenesch (Hospices Civils de Lyon) and Emmanuelle Vigier (Paris Bichat)., Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Clermont-Ferrand, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Pathogénie des Staphylocoques – Staphylococcal Pathogenesis (StaPath), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Atypical bacteria, Concordance, [SDV]Life Sciences [q-bio], FilmArray pneumonia panel, 030106 microbiology, Gastroenterology, Lower respiratory tract infection, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, Multiplex polymerase chain reaction, Diagnosis, medicine, Pneumonia, Bacterial, Humans, 030212 general & internal medicine, medicine.diagnostic_test, biology, Bacteria, business.industry, General Medicine, Syndromic panel, Multiplex PCR, medicine.disease, biology.organism_classification, 3. Good health, Pneumonia, Infectious Diseases, Bronchoalveolar lavage, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Molecular Diagnostic Techniques, Sputum, medicine.symptom, business, Multiplex Polymerase Chain Reaction
Abstract

International audience; OBJECTIVES: To evaluate performances of the rapid multiplex PCR assay BioFire FilmArray Pneumonia Panel (FA-PP) for detection of bacterial pathogens and antibiotic resistance genes in sputum, endotracheal aspirate (ETA) and bronchoalveolar lavage (BAL) specimens. METHODS: This prospective observational study was conducted in 11 French university hospitals (July to December 2018) and assessed performance of FA-PP by comparison with routine conventional methods. RESULTS: A total of 515 respiratory specimens were studied, including 58 sputa, 217 ETA and 240 BAL. The FA-PP detected at least one pathogen in 384 specimens, yielding an overall positivity rate of 74.6% (384/515). Of them, 353 (68.5%) specimens were positive for typical bacteria while eight atypical bacteria and 42 resistance genes were found. While identifying most bacterial pathogens isolated by culture (374/396, 94.4%), the FA-PP detected 294 additional species in 37.7% (194/515) of specimens. The FA-PP demonstrated positive percentage agreement and negative percentage agreement values of 94.4% (95% CI 91.7%-96.5%) and 96.0% (95% CI 95.5%-96.4%), respectively, when compared with culture. Of FA-PP false-negative results, 67.6% (46/68) corresponded to bacterial species not included in the panel. At the same semi-quantification level (in DNA copies/mL for FA-PP versus in CFU/mL for culture), the concordance rate was 43.4% (142/327) for culture-positive specimens with FA-PP reporting higher semi-quantification of ≥1 log(10) in 48.6% (159/327) of cases. Interestingly, 90.1% of detected bacteria with ≥10(6) DNA copies/mL grew significantly in culture. CONCLUSIONS: FA-PP is a simple and rapid molecular test that could complement routine conventional methods for improvement of diagnosis accuracy of pneumonia.

Published
2021
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4. Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells

Author

Sophie D. Lefevre, Pierre Rustin, Renata Santos, Jean-Michel Camadro, Dominika Sliwa, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ED 515 - Complexité du vivant, Université Pierre et Marie Curie - Paris 6 (UPMC), Physiopathologie, conséquences fonctionnelles et neuroprotection des atteintes du cerveau en développement, Université Paris Diderot - Paris 7 (UPD7)-IFR2-Institut National de la Santé et de la Recherche Médicale (INSERM), CNRS, French FA Patient Organization (AFAF), Agence Nationale de la Recherche (ANR). AFM (Association Française contre les Myopathies), AMMi (Association contre les Maladies Mitochondriales), Conseil general d'Ille et Vilaine, Neuroprotection du Cerveau en Développement / Promoting Research Oriented Towards Early Cns Therapies (PROTECT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm - Paris Descartes), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Ataxia, Saccharomyces cerevisiae Proteins, [SDV]Life Sciences [q-bio], Mutant, Biophysics, Saccharomyces cerevisiae, Mitochondrion, medicine.disease_cause, Biochemistry, GTP Phosphohydrolases, Mitochondrial Proteins, 03 medical and health sciences, 0302 clinical medicine, Iron-Binding Proteins, medicine, Humans, Fragmentation (cell biology), Molecular Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, biology, Frataxin, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Cell Biology, Yeast, Cell biology, Mitochondria, Friedreich ataxia, Oxidative stress, biology.protein, Mitochondrial dynamics, Mitochondrial fission, medicine.symptom, 030217 neurology & neurosurgery, Gene Deletion
Abstract

International audience; Friedreich ataxia (FA) is the most common recessive neurodegenerative disease. It is caused by deficiency in mitochondrial frataxin, which participates in iron-sulfur cluster assembly. Yeast cells lacking frataxin (Δyfh1 mutant) showed an increased proportion of fragmented mitochondria compared to wild-type. In addition, oxidative stress induced complete fragmentation of mitochondria in Δyfh1 cells. Genetically controlled inhibition of mitochondrial fission in these cells led to increased resistance to oxidative stress. Here we present evidence that in yeast frataxin-deficiency interferes with mitochondrial dynamics, which might therefore be relevant for the pathophysiology of FA.

Published
2012
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5. The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells

Author

Renata Santos, Frank Madeo, Nicole Boggetto, Sophie D. Lefevre, Dominika Sliwa, Emmanuel Lesuisse, Christoph Ruckenstuhl, Françoise Auchère, Caroline Brossas, Jean-Michel Camadro, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institute of Molecular Biosciences, Karl-Franzens University Graz, (IMB), Karl-Franzens-Universität Graz, and French Government (CNRS),French FA Patient Organization (AFAF), Agence Nationale de la Recherche

Subjects
Antioxidant, medicine.medical_treatment, medicine.disease_cause, Biochemistry, Metacaspase, chemistry.chemical_compound, Structural Biology, Iron-Binding Proteins, Yeasts, Yca1, chemistry.chemical_classification, 0303 health sciences, biology, Frataxin, 030302 biochemistry & molecular biology, Glutathione, 3. Good health, Mitochondria, Caspases, medicine.symptom, Oxidation-Reduction, Intracellular, Ataxia, Saccharomyces cerevisiae Proteins, Cell Respiration, Biophysics, Saccharomyces cerevisiae, Genomic Instability, Fungal Proteins, 03 medical and health sciences, Genetics, medicine, Humans, Molecular Biology, 030304 developmental biology, Reactive oxygen species, Dose-Response Relationship, Drug, Organisms, Genetically Modified, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Cell Biology, Hydrogen Peroxide, chemistry, Friedreich ataxia, Oxidative stress, biology.protein
Abstract

International audience; Friedreich ataxia is the most common recessive neurodegenerative disease and is caused by reduced expression of mitochondrial frataxin. Frataxin depletion causes impairment in iron-sulfur cluster and heme biosynthesis, disruption of iron homeostasis and hypersensitivity to oxidants. Currently no pharmacological treatment blocks disease progression, although antioxidant therapies proved to benefit patients. We show that sensitivity of yeast frataxin-deficient cells to hydrogen peroxide is partially mediated by the metacaspase. Metacaspase deletion in frataxin-deficient cells results in recovery of antioxidant capacity and heme synthesis. In addition, our results suggest that metacaspase is associated with mitochondrial respiration, intracellular redox control and genomic stability.

Published
2011
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6. Alpha-(N)-formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity.

Author

French FA, Blanz EJ Jr, Shaddix SC, and Brockman RW

Subjects
Animals, Antineoplastic Agents therapeutic use, Carcinoma drug therapy, Cell Line, Dose-Response Relationship, Drug, Formaldehyde chemical synthesis, Formaldehyde therapeutic use, Heterocyclic Compounds chemical synthesis, Heterocyclic Compounds therapeutic use, Humans, Laryngeal Neoplasms, Leukemia L1210 drug therapy, Lung Neoplasms drug therapy, Mice, Neoplasms, Experimental drug therapy, Ribonucleotides, Sarcoma 180 drug therapy, Structure-Activity Relationship, Thiosemicarbazones therapeutic use, Alcohol Oxidoreductases antagonists & inhibitors, Antineoplastic Agents chemical synthesis, Thiosemicarbazones chemical synthesis
Published
1974
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7. The influence of nutritional factors on pulmonary adenomas in mice.

Author

French FA

Subjects
Adenoma pathology, Animals, Body Weight, Choline pharmacology, Inositol pharmacology, Lung Neoplasms pathology, Mice, Mice, Inbred Strains, Niacinamide pharmacology, Nicotinic Acids deficiency, Nicotinic Acids pharmacology, Urethane adverse effects, Adenoma chemically induced, Lung Neoplasms chemically induced, Nutritional Physiological Phenomena
Published
1977
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12. Chemotherapy studies on experimental mouse tumors. IX.

Author

French FA and Blanz EJ Jr

Subjects
Adenocarcinoma drug therapy, Animals, Carcinoma 256, Walker drug therapy, Leukemia, Experimental drug therapy, Lung Neoplasms drug therapy, Melanoma drug therapy, Mice, Sarcoma 180 drug therapy, Antineoplastic Agents therapeutic use, Guanidines therapeutic use, Neoplasms, Experimental drug therapy
Published
1971

13. Chemotherapy studies on experimental mouse tumors. X.

Author

French FA and Blanz EJ Jr

Subjects
Adenocarcinoma drug therapy, Animals, Carcinoma 256, Walker drug therapy, Leukemia, Experimental drug therapy, Lung Neoplasms drug therapy, Mice, Sarcoma 180 drug therapy, Antineoplastic Agents therapeutic use, Neoplasms, Experimental drug therapy, Thiosemicarbazones therapeutic use
Published
1971

14. Antimalarial activity of guanylhydrazone salts of aromatic ketones. 2. Development of active polyhalo derivatives.

Author

DoAmaral JR, French FA, Blanz EJ Jr, and French DA

Subjects
Animals, Benzophenones therapeutic use, Bromine, Chlorine, Ethers chemical synthesis, Fluorine, Guanidines therapeutic use, Hydrazones chemical synthesis, Hydrazones therapeutic use, Iodine, Malaria drug therapy, Mice, Structure-Activity Relationship, Antimalarials chemical synthesis, Benzophenones chemical synthesis, Guanidines chemical synthesis, Hydrazines chemical synthesis
Published
1971
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22. The carcinostatic activity of 5-hydroxy-2-formylpyridine thiosemicarbazone.

Author

Blanz EJ Jr and French FA

Subjects
Adenocarcinoma drug therapy, Adenocarcinoma pathology, Animals, Bone Marrow pathology, Carcinoma, Ehrlich Tumor drug therapy, Carcinoma, Ehrlich Tumor pathology, Chemical Phenomena, Chemistry, Female, HeLa Cells enzymology, Injections, Intraperitoneal, Injections, Subcutaneous, Leukemia L1210 drug therapy, Leukemia L1210 pathology, Lymphoma drug therapy, Lymphoma pathology, Mice, Neoplasms, Experimental pathology, Sarcoma 180 drug therapy, Sarcoma 180 pathology, Thiosemicarbazones chemical synthesis, Neoplasms, Experimental drug therapy, Thiosemicarbazones administration & dosage
Published
1968

23. The carcinostatic activity of alpha-(N) heterocyclic carboxaldehyde thiosemicarbazones. I. Isoquinoline-1-carboxaldehyde thiosemicarbazone.

Author

French FA and Blanz EJ Jr

Subjects
Adenocarcinoma drug therapy, Animals, Female, In Vitro Techniques, Mice, Antineoplastic Agents administration & dosage, Carcinoma, Ehrlich Tumor drug therapy, Leukemia L1210 drug therapy, Leukemia, Experimental drug therapy, Lung Neoplasms drug therapy, Neoplasms, Experimental drug therapy, Thiosemicarbazones administration & dosage
Published
1965

26. Carcinostatic activity of thiosemicarbazones of formyl heteroaromatic compounds. VII. 2-Formylpyridine derivatives bearing additional ring substituents.

Author

Blanz EJ Jr, French FA, DoAmaral JR, and French DA

Subjects
Animals, Carcinoma drug therapy, Carcinoma, Ehrlich Tumor drug therapy, Chemical Phenomena, Chemistry, DNA biosynthesis, Leukemia L1210 drug therapy, Leukemia, Myeloid drug therapy, Lymphoma drug therapy, Melanoma drug therapy, Mice, Sarcoma, Experimental drug therapy, Thiosemicarbazones administration & dosage, Neoplasms, Experimental drug therapy, Thiosemicarbazones chemical synthesis, Thiosemicarbazones therapeutic use
Published
1970
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35. Carcinostatic activity of thiosemicarbazones of formyl heteroaromatic compounds. VI. 1-Formylisoquinoline derivatives bearing additional ring substituents, with notes on mechanism of action.

Author

French FA, Blanz EJ Jr, DoAmaral JR, and French DA

Subjects
Animals, Carcinoma drug therapy, Cell-Free System, Chemical Phenomena, Chemistry, DNA biosynthesis, Isoquinolines, Leukemia L1210 drug therapy, Leukemia, Myeloid drug therapy, Lymphoma drug therapy, Mice, Pyridines, Sarcoma, Experimental drug therapy, Neoplasms, Experimental drug therapy, Thiosemicarbazones chemical synthesis, Thiosemicarbazones therapeutic use
Published
1970
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38. The carcinostatic activity of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones. II. 3-Hydroxypyridine-2-carboxaldehyde thiosemicarbazone.

Author

French FA and Blanz EJ Jr

Subjects
Adenocarcinoma drug therapy, Animals, Carcinoma, Ehrlich Tumor drug therapy, Lung Neoplasms drug therapy, Lymphoma drug therapy, Mice, Aldehydes pharmacology, Antineoplastic Agents pharmacology, Heterocyclic Compounds pharmacology, Leukemia L1210 drug therapy, Neoplasms, Experimental drug therapy, Pyridines pharmacology, Thiosemicarbazones pharmacology
Published
1966

39. The carcinostatic activity of thiosemicarbazones of formyl heteroaromatic compounds. 3. Primary correlation.

Author

French FA and Blanz EJ Jr

Subjects
Adenocarcinoma drug therapy, Animals, Chemistry, Organic, Leukemia L1210 drug therapy, Mice, Neoplasms, Experimental drug therapy, Organic Chemistry Phenomena, Sarcoma 180 drug therapy, Antineoplastic Agents pharmacology, Pyridines pharmacology, Quinolines pharmacology, Thiosemicarbazones pharmacology
Published
1966
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40. Antimalarial activity of guanylhydrazone salts of aromatic ketones. I. Primary search for active substituent patterns.

Author

DoAmaral JR, Blanz EJ Jr, and French FA

Subjects
Animals, Antimalarials therapeutic use, Benzophenones therapeutic use, Chemical Phenomena, Chemistry, Guanidines therapeutic use, Hydrazines therapeutic use, Mice, Antimalarials chemical synthesis, Benzophenones chemical synthesis, Guanidines chemical synthesis, Hydrazines chemical synthesis, Leukemia L1210 drug therapy
Published
1969
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