1. Patient Inspiratory Maneuver Performance; Peak Lungpower, Acceleration and Volume
- Author
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Mikko Vahteristo, Ville Vartiainen, Satu Lähelmä, L. P. Malmberg, Jussi Haikarainen, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Hospital Area
- Subjects
Pulmonary and Respiratory Medicine ,Pharmaceutical Science ,DISKUS(TM) ,FLOW-RATE DEPENDENCY ,lungpower ,Pulmonary Disease, Chronic Obstructive ,Patient performance ,Administration, Inhalation ,Medicine ,VOLUNTEERS ,COPD ,Humans ,Pharmacology (medical) ,In patient ,Metered Dose Inhalers ,DRUG-DELIVERY ,airflow resistance ,Lung ,Asthma ,SALBUTAMOL ,Original Research ,EASYHALER(R) ,Inhalation ,business.industry ,Nebulizers and Vaporizers ,dry powder inhalers ,Inspiratory muscle ,Peak Inspiratory Flow Rate ,IN-VITRO ,asthma ,medicine.disease ,EFFICACY ,Anesthesia ,3121 General medicine, internal medicine and other clinical medicine ,Salbutamol ,business ,RESISTANCE ,airflow ,medicine.drug - Abstract
Background: Use of drug delivery devices between nebulizers, dry powder inhalers (DPIs), or metered dose inhalers (MDIs), for treating patients with asthma and chronic obstructive pulmonary disease (COPD), is based on patients' capability of coordinating the inhalation maneuver and achieving sufficient airflow. There are limited data available with regard to how patients meet the requirements of successful inhalation performance, and how the concept of inspiratory lungpower could be applied. The aim of this work was to study the patient inspiratory airflow profile performance in large data sets. We analyzed how the Kamin-Haidl inhalation criteria were met by patients with DPIs such as Easyhaler for combination therapy (EH-combi), Easyhaler for monotherapy (EH-mono), Diskus, and Turbuhaler (TH), and applied peak lungpower instead of peak inspiratory flow rate as an indicator of patient performance. Materials and Methods: Data sets gathered in two previous studies for DPIs, that is, EH-combi, EH-mono, Diskus, and TH, were used to analyze how inspiratory lungpower representing inspiratory muscle power, flow acceleration, and volume after peak met the inhalation criteria. The measured patient airflow profiles through inhalers were assessed for patients with asthma or COPD. Results: Based on the Kamin-Haidl inhalation criteria, successful inhalation requirements were met with EH-combi in 96.1% and with EH-mono in 92.6% of patients. The success rates were 89.5% and 84.6% with Diskus and TH, respectively, (p
- Published
- 2020