49 results on '"FIORINI, VALENTINA"'
Search Results
2. Designing Ionic Ir(III) Cyclometalated Complexes as Photocatalysts for Light Assisted ATRP of MMA. A Combined Experimental and Mechanistic Study
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Vigarani, Giulia, primary, Marchini, Edoardo, additional, Previati, Eleonora, additional, Giorgini, Loris, additional, Zacchini, Stefano, additional, Argazzi, Roberto, additional, Massi, Massimiliano, additional, Fiorini, Valentina, additional, Caramori, Stefano, additional, and Stagni, Stefano, additional
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- 2024
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3. Colourless luminescent solar concentrators based on Iridium(III)-Phosphors
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Fiorini, Valentina, Monti, Nicola, Vigarani, Giulia, Santi, Greta, Fasulo, Francesca, Massi, Massimiliano, Giorgini, Loris, Muñoz-García, Ana B., Pavone, Michele, Pucci, Andrea, and Stagni, Stefano
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- 2021
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4. Trapping an unprecedented octacoordinated iron(II) complex with neutral bis-tetrazolylpyridyl ligands and solvent molecules.
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Rigamonti, Luca, Marchi, Lorenzo, Fiorini, Valentina, Stagni, Stefano, Zacchini, Stefano, Pinkowicz, Dawid, Dziedzic-Kocurek, Katarzyna, Forni, Alessandra, Muniz Miranda, Francesco, and Mazzoni, Rita
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IRON ,COORDINATE covalent bond ,SINGLE crystals ,LIGANDS (Chemistry) ,SOLVENTS ,SPIN labels - Abstract
Iron(II) can show a very rich coordination chemistry with concomitant modulation of its properties as promising functional materials. Metalation of the neutral tridentate nitrogen-donor mer-coordinating ligand 2,6-bis(2-(methyl)-2H-tetrazol-5-yl)pyridine (Me
2 btp) with Fe(ClO4 )2 ·6H2 O through accurate solvent polarity control enables the selective crystallization of [FeHS/LS (Me2 btp)2 ](ClO4 )2 ·MeCN·2.75H2 O (2HS/LS ·MeCN·2.75H2 O) as red rods, where half of the iron(II) centres resides in the low spin (LS, S = 0) state and the other half is in the high spin (HS, S = 2) state. The red rods spontaneously convert into yellow crystals once removed from the mother liquor and exposed to air due to solvent rearrangement within the crystal packing; these new crystals can be assigned to [FeHS (Me2 btp)2 ](ClO4 )2 ·solvent (2HS ·solvent) where all the iron(II) centres are now blocked in the HS state, as confirmed by magnetic measurements. The polarity of the crystallization solvent, together with the maintenance of the crystals within the mother liquor, are pivotal for the reactivity and interconversion of different species. Indeed, upon long standing in solution, 2HS/LS ·MeCN·2.75H2 O converts to another form of red crystals belonging to [FeLS (Me2 btp)2 ][FeHS (Me2 btp)(MeCN)2 (H2 O)](ClO4 )4 ·MeCN (2LS ·3HS ·MeCN), as confirmed by single crystal X-ray diffraction data. In this co-crystal, the iron(II) in 2 resides in the LS state at all temperatures while the iron(II) in 3 is blocked in the HS state. Well-formed yellow crystals could be also isolated among the red crystals of 2HS/LS ·MeCN·2.75H2 O, and they could be identified as the unprecedented octacoordinated species [Fe(Me2 btp)2 (MeCN)(H2 O)](ClO4 )2 ·H2 O (1·H2 O) by single-crystal X-ray diffraction. These yellow crystals are stable in the air, but slowly convert into 2LS ·3HS ·MeCN if kept in the mother liquor for about one week. 1·H2 O can be considered the trapped intermediate in the solid state during the conversion of [FeHS (Me2 btp)2 ]2+ into [FeHS (Me2 btp)(MeCN)2 (H2 O)]2+ in solution, where the two tridentate ligands in the starting species can unfold to accommodate coordinated MeCN and H2 O molecules, as confirmed by theoretical calculations, and eventually one of the two Me2 btp is completely replaced by the solvent. [ABSTRACT FROM AUTHOR]- Published
- 2024
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5. Social Impact Through Inclusion: The Case of De Voorkamer.
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Fiorini, Valentina and Fiorini, Valentina
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This study attempts to understand the relationship between De Voorkamer (a community organisation in Utrecht, the Netherlands) and its community and how social impact is created through this interaction. This is done through ethnographic research paired with interviews conducted with organisational members, volunteers and participants of De Voorkamer’s events. In addition, visuals are used throughout to better depict the processes at play. The paper’s main findings suggest that the impact created through the relationship between De Voorkamer and its community is managed through a sense of inclusion and belonging within the space. Power dynamics play a role in this relationship since it determines the outcome of the inclusion and integration processes. De Voorkamer’s cocreation initiative was also seen as an empowering tool that creates a stronger bond with the organisation and a stronger sense of belonging. Social capital is also highlighted as a crucial ingredient for social impact, with the paper delving into how social capital is created through the inclusion process. Lastly, mental health benefits were a recurring theme within the paper as a spillover effect of the inclusion process. The paper goes into ways De Voorkamer can improve its social impact creation. Specifically by increasing the accessibility of information about events and programs and providing more formal education opportunities. De Voorkamer could also benefit from more intentional impact planning and evaluation to ensure its programs and activities meet the community’s needs. Overall, this study highlights the importance of community-led spaces like De Voorkamer for fostering inclusion and belonging among immigrants and refugees and strengthening ties within communities. De Voorkamer acts as a bridge between marginalised, disadvantaged groups and their social needs, which prevents them from the risk of social exclusion and the adverse outcomes which are associated with it. The study provides ins
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- 2023
6. Prenatal Clinical Findings in RASA1-Related Capillary Malformation-Arteriovenous Malformation Syndrome
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Coccia, Emanuele, primary, Valeri, Lara, additional, Zuntini, Roberta, additional, Caraffi, Stefano Giuseppe, additional, Peluso, Francesca, additional, Pagliai, Luca, additional, Vezzani, Antonietta, additional, Pietrangiolillo, Zaira, additional, Leo, Francesco, additional, Melli, Nives, additional, Fiorini, Valentina, additional, Greco, Andrea, additional, Lepri, Francesca Romana, additional, Pisaneschi, Elisa, additional, Marozza, Annabella, additional, Carli, Diana, additional, Mussa, Alessandro, additional, Radio, Francesca Clementina, additional, Conti, Beatrice, additional, Iascone, Maria, additional, Gargano, Giancarlo, additional, Novelli, Antonio, additional, Tartaglia, Marco, additional, Zuffardi, Orsetta, additional, Bedeschi, Maria Francesca, additional, and Garavelli, Livia, additional
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- 2023
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7. Synthesis and Stereodynamic and Emission Properties of Dissymmetric Bis-Aryl Carbazole Boranes and Identification of a CPL-Active B–C Atropisomeric Compound
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Pecorari, Daniel, primary, Giuliani, Emanuele, additional, Mazzanti, Andrea, additional, Stagni, Stefano, additional, Fiorini, Valentina, additional, Vigarani, Giulia, additional, Zinna, Francesco, additional, Pescitelli, Gennaro, additional, and Mancinelli, Michele, additional
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- 2023
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8. Alkyl tetrazoles as diimine (“diim”) ligands for fac-[Re(diim)(CO)3(L)]-type complexes. Synthesis, characterization and preliminary studies of the interaction with bovine serum albumin
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Monti, Nicola, primary, Longo, Veronica, additional, Zacchini, Stefano, additional, Vigarani, Giulia, additional, Giorgini, Loris, additional, Bonora, Eugenia, additional, Massi, Massimiliano, additional, Fiorini, Valentina, additional, and Stagni, Stefano, additional
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- 2021
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9. Highly twisted carbazole-borane derivatives: B–N stereodynamic analysis and consequences on their emission properties
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Pecorari, Daniel, primary, Mazzanti, Andrea, additional, Gianvittorio, Stefano, additional, Foschi, Simone, additional, Stagni, Stefano, additional, Fiorini, Valentina, additional, and Mancinelli, Michele, additional
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- 2021
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10. Antibacterial activity of a new class of tris homoleptic Ru (II)‐complexes with alkyl‐tetrazoles as diimine‐type ligands
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Monti, Nicola, primary, Zacchini, Stefano, additional, Massi, Massimiliano, additional, Hochkoeppler, Alejandro, additional, Giorgini, Loris, additional, Fiorini, Valentina, additional, Stefan, Alessandra, additional, and Stagni, Stefano, additional
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- 2020
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11. Use of Cotton Textiles Coated by Ir(III) Tetrazole Complexes within Ceramic Silica Nanophases for Photo-Induced Self-Marker and Antibacterial Application
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Zanoni, Ilaria, primary, Blosi, Magda, additional, Fiorini, Valentina, additional, Crosera, Matteo, additional, Ortelli, Simona, additional, Stagni, Stefano, additional, Stefan, Alessandra, additional, Psilodimitrakopoulos, Sotiris, additional, Stratakis, Emmanuel, additional, Larese Filon, Francesca, additional, and Costa, Anna Luisa, additional
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- 2020
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12. Superacid Aquivion® PFSA as an efficient catalyst for the gas phase dehydration of ethanol to ethylene in mild conditions
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Andreoli, Sara, primary, Oldani, Claudio, additional, Fiorini, Valentina, additional, Stagni, Stefano, additional, Fornasari, Giuseppe, additional, and Albonetti, Stefania, additional
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- 2020
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13. New examples of Ru(ii)-tetrazolato complexes as thiocyanate-free sensitizers for dye-sensitized solar cells
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Fiorini, Valentina, primary, Marchini, Edoardo, additional, Averardi, Mattia, additional, Giorgini, Loris, additional, Muzzioli, Sara, additional, Dellai, Angela, additional, Argazzi, Roberto, additional, Sanson, Alessandra, additional, Sangiorgi, Nicola, additional, Caramori, Stefano, additional, and Stagni, Stefano, additional
- Published
- 2020
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14. EXCHANGE TRANSFUSION IN SEVERE NEONATAL JAUNDICE: A FIVE YEARSʼ MODENA EXPERIENCE: OC_20
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Fiorini, Valentina, Roversi, Maria F., Cattani, Silvia, Bortoli, Elisa, Ruberto, Claudio, Paltrinieri, Anna L., Casa, Elisa Della, Gallo, Claudio, Garetti, Elisabetta, and Ferrari, Fabrizio
- Published
- 2006
15. Complementary Approaches to Imaging Subcellular Lipid Architectures in Live Bacteria Using Phosphorescent Iridium Complexes and Raman Spectroscopy
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Ranieri, Anna Maria, primary, Caporale, Chiara, additional, Fiorini, Valentina, additional, Hubbard, Alysia, additional, Rigby, Paul, additional, Stagni, Stefano, additional, Watkin, Elizabeth, additional, Ogden, Mark I., additional, Hackett, Mark J., additional, and Massi, Massimiliano, additional
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- 2019
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16. Heteromultimetallic compounds based on polyfunctional carboxylate linkers
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Jantan, Khairil A., primary, McArdle, James M., additional, Mognon, Lorenzo, additional, Fiorini, Valentina, additional, Wilkinson, Luke A., additional, White, Andrew J. P., additional, Stagni, Stefano, additional, Long, Nicholas J., additional, and Wilton-Ely, James D. E. T., additional
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- 2019
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17. Severe acquired cytomegalovirus infection in a full-term, formula-fed infant: Case Report
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Pietrosemoli Paola, Guaraldi Nicola, Rivi Cristina, Vagnarelli Federica, Fiorini Valentina, Rossi Cecilia, Berardi Alberto, Lazzarotto Tiziana, and Ferrari Fabrizio
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Pediatrics ,RJ1-570 - Abstract
Abstract Background Cases of cytomegalovirus colitis are exceptionally reported in immuno-competent infant. The pathogenesis is uncertain but breast-feeding is considered as a main source of postnatal infection. Case Presentation Here we report a full-term, formula-fed infant who developed a severe cytomegalovirus anaemia and colitis when aged 2 months. Conclusion Even if the molecular identity between the cytomegalovirus-isolate of the infant and the maternal virus could not be demonstrated, we confirmed through laboratory investigation that cytomegalovirus infection was acquired postnatally. However, the source of cytomegalovirus infection remained unclear. Alternative modes of cytomegalovirus transmission are discussed.
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- 2011
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18. The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population-based study
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Berardi, Alberto, Baroni, Lorenza, Bacchi Reggiani, Maria Letizia, Ambretti, Simone, Biasucci, Giacomo, Bolognesi, Serenella, Capretti, Maria Grazia, Carretto, Edoardo, Ciccia, Matilde, Fiorini, Valentina, Fortini, Cinzia, Gargano, Giancarlo, Pedna, Maria Federica, Rizzo, Vittoria, Creti, Roberta, Ferrari, Fabrizio, Memo, L., Nicolini, G., Campanile, A., Tridapalli, E., Ciccia, M., Bastelli, A., Sandri, F., Ambretti, S., Capretti, M. G., Gentili, A., Ragni, L., Albarelli, A., Piscina, A., Borghi, A., Simoni, A., Fiorini, V., Grande, E. D., Polese, A., Biasini, A., China, M. C., Rizzo, V., Zucchini, A., Malaguti, L., Contiero, R., Fortini, C., Garani, G., Rossi, M. R., Nasi, S., Bacchini, P., Baldassarri, P., Pulvirenti, R. M., Vaienti, F., Venturoli, V., Bidetti, M. L., Colla, R., Toniato, M., Carlo, C. D., Lanari, M., Serra, L., Silvestrini, D., Facchinetti, F., Ferrari, F., Lugli, L., Venturelli, C., Sarti, M., Volta, A., Dodi, I., Gambini, L., Guidi, B., Bertelli, M., Biasucci, G., Chiarabini, R., Padrini, D., Piepoli, M., Riboni, S., Rubbi, P., Pedna, M. F., Sambri, V., Perrone, A., Preti, P., Marchetti, F., Piccinini, G. C., Amarri, S., Carretto, E., Gargano, G., Pedori, S., Riva, M., Rossi, C., Zuelli, C., Bolognesi, S., Papa, I., Vergine, G., Viola, L., Chiossi, C., Pagano, R., Zanacca, C., Palmieri, R., Berardi, Alberto, Baroni, Lorenza, Bacchi Reggiani, Maria Letizia, Ambretti, Simone, Biasucci, Giacomo, Bolognesi, Serenella, Capretti, Maria Grazia, Carretto, Edoardo, Ciccia, Matilde, Fiorini, Valentina, Fortini, Cinzia, Gargano, Giancarlo, Pedna, Maria Federica, Rizzo, Vittoria, Creti, Roberta, Ferrari, Fabrizio, and GBS Prevention Working Group Emilia-Romagna [,Lanari, Marcello,]
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Pediatrics ,Antibiotics ,group B streptococcu ,Logistic regression ,medicine.disease_cause ,Severity of Illness Index ,Group B ,0302 clinical medicine ,Risk Factors ,Medicine ,Birth Weight ,030212 general & internal medicine ,Escherichia coli Infections ,Streptococcus ,Gestational age ,meningitis ,Obstetrics and Gynecology ,Drug Resistance, Microbial ,intrapartum chemoprophylaxi ,Perinatology and Child Health ,meningiti ,Anti-Bacterial Agents ,Italy ,Regression Analysis ,Neonatal Sepsis ,Meningitis ,Early-onset sepsis ,group B streptococcus ,intrapartum chemoprophylaxis ,newborn infant ,Pediatrics, Perinatology and Child Health ,Infant, Premature ,Cohort study ,medicine.medical_specialty ,medicine.drug_class ,Statistics, Nonparametric ,Streptococcus agalactiae ,Sepsis ,03 medical and health sciences ,030225 pediatrics ,Streptococcal Infections ,Escherichia coli ,Humans ,Retrospective Studies ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Early-onset sepsi ,Ampicillin ,Gentamicins ,business - Abstract
Objective: To provide the first Italian data on pathogens causing early-onset sepsis (EOS) and their antimicrobial susceptibility, after the successfully prevention of Group B streptococcus (GBS) EOS. Methods: Retrospective area-based cohort study from Emilia-Romagna (Italy). Cases of EOS registered (from 2009 to 2012) in all gestational age neonates were reviewed. Results: Live births (LB) numbered 146 682. Ninety neonates had EOS and 12 died (incidence rates of 0.61 and 0.08/1000 LB, respectively). EOS and mortality were the highest among neonates with a birth weight n = 27, 0.18/1000 LB) and Escherichia coli (n = 19, 0.13/1000 LB). Most infants affected by E. coli EOS were born preterm (n = 13), had complications (n = 4) or died (n = 7). Among 90 isolates tested, only 3 were resistant to both first line empirical antibiotics. Multivariate logistic regression analysis showed that low gestational age, caesarean section and low platelet count at presentation were significantly associated with death or brain lesions (area under ROC curve = 0.939, H-L = 0.944, sensitivity 76.0%, specificity 90.7%). Conclusions: GBS slightly exceeds E. coli as a cause of EOS. However, E. coli is the prominent cause of death, complications and in most cases affects preterm neonates. Empirical antimicrobial therapy of EOS seems appropriate.
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- 2015
19. Design, Synthesis and Photophysical Characterization of Luminescent Metal Tetrazolate Complexes
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Fiorini, Valentina
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CHIM/03 Chimica generale e inorganica - Abstract
Over the past few decades, the scenario of luminescent transition metal complexes has experienced a great blossom. In this context, the spotlight of the research program that I have carried out in my PhD studies has been dealing with the design, the preparation and the study of the photophysical properties of a new series of luminescent metal complexes containing anionic ligands such as 5-aryl tetrazolates [R-CN4]-. The choice of this specific class of nitrogen rich derivatives stemmed from the observation of how these ligands can effectively rule the luminescent output of the corresponding Ru (II) polypyridyls, Ir(III) bis-cyclometalates and tris carbonyl Re(I)-diimine complexes. In particular, the synthetic versatility of tetrazolate derivatives combined with the peculiar sensitivity to electrophilic additions – both permanent and reversible - that is displayed by the coordinated tetrazolate ring constitute the background for the further exploitment of their coordination chemistry and their applicative panorama. On these basis, we have recently prepared the first examples of anionic Ir(III) tetrazolate complexes and new Re(I)-based species containing ditopic tetrazolate ligands, with particular attention dedicated to their use as components for white light emitting Ir(III)-based ion pairs (“soft salts”), for covalently linked Ir(III)-Re(I) dyads, and for the investigation of Re(I) tetrazolate complexes as luminescent chemosensors. Moreover, studies which have dealt with Ru(II) tetrazolate complexes, pointed the way for the preparation of tetrazole –based Dye Sensitized Solar Cells.
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- 2017
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20. Oxidative Coupling of Imino, Amide Platinum(II) Complexes Yields Highly Conjugated Blue Dimers
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Esposito, Roberto, Calvanese, Luisa, Cucciolito, Maria Elena, D’Auria, Gabriella, Falcigno, Lucia, Fiorini, Valentina, Pezzella, Prisco, Roviello, Giuseppina, Stagni, Stefano, Talarico, Giovanni, and Ruffo, Francesco
- Abstract
Platinum(II) olefin compounds [PtMe(N,N′-imino, amide)(η2-olefin)] have been found to dimerize spontaneously in solution, yielding dinuclear complexes through an oxidative coupling. The extended conjugation within the molecules produces an intense blue color, and the properties of the compounds have been investigated through NMR spectroscopy, optical measurements, and theoretical calculations. The solid-state structure of a representative compound has been solved.
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- 2024
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21. Encapsulation of cationic iridium(iii) tetrazole complexes into a silica matrix: synthesis, characterization and optical properties
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Zanoni, Ilaria, primary, Fiorini, Valentina, additional, Rosado, Marcos, additional, Ballesteros, Belén, additional, Androulidaki, Maria, additional, Blosi, Magda, additional, Ortelli, Simona, additional, Stagni, Stefano, additional, Dondi, Michele, additional, and Costa, Anna Luisa, additional
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- 2018
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22. Luminescent protein staining with Re(i) tetrazolato complexes
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Fiorini, Valentina, primary, Bergamini, Linda, additional, Monti, Nicola, additional, Zacchini, Stefano, additional, Plush, Sally E., additional, Massi, Massimiliano, additional, Hochkoeppler, Alejandro, additional, Stefan, Alessandra, additional, and Stagni, Stefano, additional
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- 2018
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23. Oxidative Coupling of Imino, Amide Platinum(II) Complexes Yields Highly Conjugated Blue Dimers
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Esposito, Roberto, primary, Calvanese, Luisa, additional, Cucciolito, Maria Elena, additional, D’Auria, Gabriella, additional, Falcigno, Lucia, additional, Fiorini, Valentina, additional, Pezzella, Prisco, additional, Roviello, Giuseppina, additional, Stagni, Stefano, additional, Talarico, Giovanni, additional, and Ruffo, Francesco, additional
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- 2017
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24. The stepwise generation of multimetallic complexes based on a vinylbipyridine linkage and their photophysical properties
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Toscani, Anita, primary, Jantan, Khairil A., additional, Hena, Jubeda B., additional, Robson, Jonathan A., additional, Parmenter, Emily J., additional, Fiorini, Valentina, additional, White, Andrew J. P., additional, Stagni, Stefano, additional, and Wilton-Ely, James D. E. T., additional
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- 2017
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25. Group B Streptococcus early-onset disease and observation of well-appearing newborns.
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Berardi, Alberto, Spada, Caterina, Reggiani, Maria Letizia Bacchi, Creti, Roberta, Baroni, Lorenza, Capretti, Maria Grazia, Ciccia, Matilde, Fiorini, Valentina, Gambini, Lucia, Gargano, Giancarlo, Papa, Irene, Piccinini, Giancarlo, Rizzo, Vittoria, Sandri, Fabrizio, Lucaccioni, Laura, and null, null
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STREPTOCOCCUS ,STREPTOCOCCUS agalactiae ,DEVELOPMENTAL biology ,ANTIBIOTIC prophylaxis ,BODY fluids ,INFANTS - Abstract
Background: International guidelines lack a substantial consensus regarding management of asymptomatic full-term and late preterm neonates at risk for early-onset disease (EOS). Large cohorts of newborns are suitable to increase the understanding of the safety and efficacy of a given strategy. Methods: This is a prospective, area-based, cohort study involving regional birth facilities of Emilia-Romagna (Italy). We compared cases of EOS (at or above 35 weeks' gestation) registered in 2003–2009 (baseline period: 266,646 LBs) and in 2010–2016, after introduction of a new strategy (serial physical examinations, SPEs) for managing asymptomatic neonates at risk for EOS (intervention period: 265,508 LBs). Results: There were 108 cases of EOS (baseline period, n = 60; intervention period, n = 48). Twenty-two (20.4%) remained asymptomatic through the first 72 hours of life, whereas 86 (79.6%) developed symptoms, in most cases (52/86, 60.5%) at birth or within 6 hours. The median age at presentation was significantly earlier in the intrapartum antibiotic prophylaxis (IAP)-exposed than in the IAP-unexposed neonates (0 hours, IQR 0.0000–0.0000 vs 6 hours, IQR 0.0000–15.0000, p<0.001). High number of neonates (n = 531) asymptomatic at birth, exposed to intrapartum fever, should be treated empirically for each newborn who subsequently develops sepsis. IAP exposed neonates increased (12% vs 33%, p = 0.01), age at presentation decreased (median 6 vs 1 hours, p = 0.01), whereas meningitis, mechanical ventilation and mortality did not change in baseline vs intervention period. After implementing the SPEs, no cases had adverse outcomes due to the strategy, and no cases developed severe disease after 6 hours of life. Conclusions: Infants with EOS exposed to IAP developed symptoms at birth in almost all cases, and those who appeared well at birth had a very low chance of having EOS. The risk of EOS in neonates (asymptomatic at birth) exposed to intrapartum fever was low. Although definite conclusions on causation are lacking, our data support SPEs of asymptomatic newborns at risk for EOS. SPEs seems a safe and effective alternative to laboratory screening and empirical antibiotic therapy. [ABSTRACT FROM AUTHOR]
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- 2019
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26. Further Developments in the Chemistry of Ir(III)-Tetrazolate Complexes
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FIORINI, VALENTINA, STAGNI, STEFANO, Società Chimica Italiana, Sigma-Aldrich, Valentina Fiorini, and Stefano Stagni
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TETRAZOLATES ,IRIDIUM CYCLOMETALATED COMPLEXES ,LUMINESCENCE - Published
- 2014
27. An area-based study on intrapartum antibiotic prophylaxis for preventing group B streptococcus early-onset disease: advances and limitations
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Berardi, Alberto, primary, Rossi, Cecilia, additional, Bacchi Reggiani, Maria Letizia, additional, Bastelli, Annalisa, additional, Capretti, Maria Grazia, additional, Chiossi, Claudio, additional, Fiorini, Valentina, additional, Gambini, Lucia, additional, Gavioli, Sara, additional, Lanari, Marcello, additional, Memo, Luigi, additional, Papa, Irene, additional, Pini, Luana, additional, Rizzo, Maria Vittoria, additional, Zucchini, Andrea, additional, Facchinetti, Fabio, additional, and Ferrari, Fabrizio, additional
- Published
- 2016
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28. Fully Ir(iii) tetrazolate soft salts: the road to white-emitting ion pairs
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Fiorini, Valentina, primary, D'Ignazio, Andrea, additional, Magee, Karen D. M., additional, Ogden, Mark I., additional, Massi, Massimiliano, additional, and Stagni, Stefano, additional
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- 2016
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29. Negatively charged Ir(iii) cyclometalated complexes containing a chelating bis-tetrazolato ligand: synthesis, photophysics and the study of reactivity with electrophiles
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Fiorini, Valentina, primary, Zacchini, Stefano, additional, Raiteri, Paolo, additional, Mazzoni, Rita, additional, Zanotti, Valerio, additional, Massi, Massimiliano, additional, and Stagni, Stefano, additional
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- 2016
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30. Targeting divalent metal cations with Re(i) tetrazolato complexes
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Fiorini, Valentina, primary, Ranieri, Anna Maria, additional, Muzzioli, Sara, additional, Magee, Karen D. M., additional, Zacchini, Stefano, additional, Akabar, Nurshadrina, additional, Stefan, Alessandra, additional, Ogden, Mark I., additional, Massi, Massimiliano, additional, and Stagni, Stefano, additional
- Published
- 2015
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31. Methylated Re(i) tetrazolato complexes: photophysical properties and Light Emitting Devices
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Werrett, Melissa V., primary, Huff, Gregory S., additional, Muzzioli, Sara, additional, Fiorini, Valentina, additional, Zacchini, Stefano, additional, Skelton, Brian W., additional, Maggiore, Antonio, additional, Malicka, Joanna M., additional, Cocchi, Massimo, additional, Gordon, Keith C., additional, Stagni, Stefano, additional, and Massi, Massimiliano, additional
- Published
- 2015
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32. Introducing a New Family of Biotinylated Ir(III)-Pyridyltriazole Lumophores: Synthesis, Photophysics, and Preliminary Study of Avidin-Binding Properties
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Baschieri, Andrea, primary, Muzzioli, Sara, additional, Fiorini, Valentina, additional, Matteucci, Elia, additional, Massi, Massimiliano, additional, Sambri, Letizia, additional, and Stagni, Stefano, additional
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- 2014
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33. Methylation of Ir(iii)-tetrazolato complexes: an effective route to modulate the emission outputs and to switch to antimicrobial properties.
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Fiorini, Valentina, Zanoni, Ilaria, Zacchini, Stefano, Costa, Anna Luisa, Hochkoeppler, Alejandro, Zanotti, Valerio, Ranieri, Anna Maria, Massi, Massimiliano, Stefan, Alessandra, and Stagni, Stefano
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ANTI-infective agents , *METHYLATION , *X-ray diffraction , *MICROORGANISMS , *CATIONIC polymers - Abstract
Two neutral cyclometalated Ir(iii)-tetrazolato complexes that differ by variations of the substituents on either the phenylpyridine or the tetrazolate ligand have been converted into the corresponding methylated and cationic analogues. NMR (1H and 13C) characterization of the Ir(iii) complexes provided the results in agreement with the chemo- and regioselective character of methylation at the N-3 position of the Ir(iii)-coordinated tetrazolato ring. This evidence was further corroborated by the analysis of the molecular structures of the cationic complexes obtained by X-ray diffraction. In view of the photophysical properties, the addition of a methyl moiety to neutral Ir(iii) tetrazolates, which behave as sky-blue or orange phosphors, caused a systematic red shift of their phosphorescence output. The transformation of neutral Ir(iii) tetrazolates into cationic Ir(iii)-tetrazole complexes was screened for any eventual antimicrobial activity in vitro against Gram negative (E. coli) and Gram positive (D. radiodurans) microorganisms. While both kinds of complexes were not active against E. coli, the conversion of the neutral Ir(iii) tetrazolates into the corresponding methylated and cationic Ir(iii)tetrazole derivatives determined the turn-on of a good to excellent antimicrobial activity toward Gram positive Deinococcus radiodurans, a non-pathogenic bacterium that is listed as one of the toughest microorganisms in light of its outstanding resistance to radiation and oxidative stress. [ABSTRACT FROM AUTHOR]
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- 2017
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34. An area-based study on intrapartum antibiotic prophylaxis for preventing group B streptococcus early-onset disease: advances and limitations.
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Berardi, Alberto, Rossi, Cecilia, Bacchi Reggiani, Maria Letizia, Bastelli, Annalisa, Capretti, Maria Grazia, Chiossi, Claudio, Fiorini, Valentina, Gambini, Lucia, Gavioli, Sara, Lanari, Marcello, Memo, Luigi, Papa, Irene, Pini, Luana, Rizzo, Maria Vittoria, Zucchini, Andrea, Facchinetti, Fabio, and Ferrari, Fabrizio
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STREPTOCOCCUS ,PREVENTIVE medicine ,FEMALES ,STREPTOCOCCACEAE ,STREPTOCOCCAL disease prevention ,ANTIBIOTICS ,PREMATURE infants ,MATERNAL health services ,MEDICAL protocols ,RECTUM ,STREPTOCOCCAL diseases ,VAGINA ,RETROSPECTIVE studies ,VERTICAL transmission (Communicable diseases) ,AMPICILLIN ,ANTIBIOTIC prophylaxis ,INFECTIOUS disease transmission - Abstract
Introduction: The prevalence of maternal group-B-streptococcus (GBS) colonization and risk factors (RFs) for neonatal early-onset disease (EOD) in Europe are poorly defined. Large-scale information concerning adherence to recommendations for preventing GBS-EOD are lacking.Materials and Methods: This was a 3-month retrospective area-based study including all regional deliveries ≥35 weeks' gestation (in 2012). The sensitivity, specificity, positive and negative predictive values, odds ratio and receiver operating characteristic (ROC) curve for intrapartum antibiotic prophylaxis (IAP) among full-term and preterm deliveries and prolonged membrane rupture (PROM) were calculated.Results: Among 7133 women, 259 (3.6%) were preterm (35-36 weeks' gestation). Full-term women were 6874, and 876 (12.7%) had at least 1 RF. Most women (6495) had prenatal screening and 21.4% (1390) were GBS positive. IAP was given to 2369 (33.2%) women (preterm, n = 166; full term, n = 2203). Compared to full-term, preterm women were less likely to receive IAP when indicated (73.2% versus 90.3%, p < 0.01). Full-term women represented the largest area under the curve (AUC, 0.87). PROM showed the highest sensitivity (98.6%), but the lowest specificity (6.9%) and AUC (0.53).Conclusions: Large-scale prenatal screening and IAP are feasible. Women delivering preterm are less likely to receive IAP when indicated. Most unnecessary antibiotics are given in cases of PROM. [ABSTRACT FROM AUTHOR]- Published
- 2017
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35. The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population-based study.
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Berardi, Alberto, Baroni, Lorenza, Bacchi Reggiani, Maria Letizia, Ambretti, Simone, Biasucci, Giacomo, Bolognesi, Serenella, Capretti, Maria Grazia, Carretto, Edoardo, Ciccia, Matilde, Fiorini, Valentina, Fortini, Cinzia, Gargano, Giancarlo, Pedna, Maria Federica, Rizzo, Vittoria, Creti, Roberta, Ferrari, Fabrizio, and GBS Prevention Working Group Emilia-Romagna
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STREPTOCOCCUS agalactiae ,NEONATAL diseases ,SEPSIS ,COHORT analysis ,MICROBIAL sensitivity tests - Abstract
Objective: To provide the first Italian data on pathogens causing early-onset sepsis (EOS) and their antimicrobial susceptibility, after the successfully prevention of Group B streptococcus (GBS) EOS.Methods: Retrospective area-based cohort study from Emilia-Romagna (Italy). Cases of EOS registered (from 2009 to 2012) in all gestational age neonates were reviewed.Results: Live births (LB) numbered 146 682. Ninety neonates had EOS and 12 died (incidence rates of 0.61 and 0.08/1000 LB, respectively). EOS and mortality were the highest among neonates with a birth weight <1000 g (20.37/1000 LB and 8.49/1000 LB, respectively). The most common pathogens were GBS (n = 27, 0.18/1000 LB) and Escherichia coli (n = 19, 0.13/1000 LB). Most infants affected by E. coli EOS were born preterm (n = 13), had complications (n = 4) or died (n = 7). Among 90 isolates tested, only 3 were resistant to both first line empirical antibiotics. Multivariate logistic regression analysis showed that low gestational age, caesarean section and low platelet count at presentation were significantly associated with death or brain lesions (area under ROC curve = 0.939, H-L = 0.944, sensitivity 76.0%, specificity 90.7%).Conclusions: GBS slightly exceeds E. coli as a cause of EOS. However, E. coli is the prominent cause of death, complications and in most cases affects preterm neonates. Empirical antimicrobial therapy of EOS seems appropriate. [ABSTRACT FROM AUTHOR]- Published
- 2016
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36. Severe acquired cytomegalovirus infection in a full-term, formula-fed infant: Case Report
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Berardi, Alberto, primary, Rossi, Cecilia, additional, Fiorini, Valentina, additional, Rivi, Cristina, additional, Vagnarelli, Federica, additional, Guaraldi, Nicola, additional, Pietrosemoli, Paola, additional, Lazzarotto, Tiziana, additional, and Ferrari, Fabrizio, additional
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- 2011
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37. Introducing a New Family of Biotinylated Ir(III)-PyridyltriazoleLumophores: Synthesis, Photophysics, and Preliminary Study of Avidin-BindingProperties.
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Baschieri, Andrea, Muzzioli, Sara, Fiorini, Valentina, Matteucci, Elia, Massi, Massimiliano, Sambri, Letizia, and Stagni, Stefano
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- 2014
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38. Encapsulation of cationic iridium(iii) tetrazole complexes into a silica matrix : synthesis, characterization and optical properties
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Simona Ortelli, Marcos Rosado, Ilaria Zanoni, Anna Luisa Costa, Maria Androulidaki, Michele Dondi, Belén Ballesteros, Stefano Stagni, Valentina Fiorini, Magda Blosi, European Commission, Ministerio de Economía, Industria y Competitividad (España), Ministero dell'Istruzione, dell'Università e della Ricerca, Centre for Research and Technology (Greece), Ministerio de Economía y Competitividad (España), Zanoni, Ilaria [0000-0001-8692-3460], Fiorini, Valentina [0000-0003-0467-6705], Ballesteros, Belén [0000-0002-1958-8911], Blosi, Magda [0000-0001-8841-247X], Ortelli, Simona [0000-0002-0868-3315], Stagni, Stefano [0000-0002-7260-4845], Dondi, Michele [0000-0001-6606-1146], Costa, Anna Luisa [0000-0003-1407-6498], Zanoni, Ilaria, Fiorini, Valentina, Rosado, Marco, Ballesteros, Belén, Androulidaki, Maria, Blosi, Magda, Ortelli, Simona, Stagni, Stefano, Dondi, Michele, Costa, Anna Luisa, ARAG - AREA FINANZA E PARTECIPATE, DIP. DI CHIMICA 'G.CIAMICIAN', DIP. DI CHIMICA INDUSTRIALE E DEI MATERIALI, DIPARTIMENTO DI CHIMICA INDUSTRIALE 'TOSO MONTANARI', Da definire, and AREA MIN. 03 - Scienze chimiche
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Materials Chemistry2506 Metals and Alloys ,tetrazole complex ,Colloidal silica ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,Catalysis ,Chemistry (all) ,7. Clean energy ,01 natural sciences ,Catalysi ,chemistry.chemical_compound ,Polymer chemistry ,Pyridine ,Materials Chemistry ,Tetrazole ,Iridium ,Aqueous solution ,Quinoline ,Cationic polymerization ,General Chemistry ,iridium ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,silica ,encapsulation ,0210 nano-technology ,Phosphorescence - Abstract
Herein we report the easy incorporation of brightly phosphorescent cationic iridium(III) tetrazole complexes into a silica based matrix via an easily scalable colloidal process. For this purpose, two cationic Ir(III) emitters bearing 5-aryl tetrazole ligands (R-CN4) were selected: blue [F2IrPTZ-Me]+ (C^N = F2ppy; N^N = PTZ-Me – 2-(2-methyl-2H-tetrazol-5-yl)pyridine) and red [IrQTZ-Me]+ (C^N = ppy; N^N = QTZ-Me – 2-(2-methyl-2H-tetrazol-5-yl)quinoline). The cationic complexes were readily adsorbed to negatively charged silica nanoparticles and trapped in the sol–gel matrix. The sol-to-solid phase transfer was performed by using an innovative spray-freeze-drying technique, leading to the formation of phosphorescent solid micro-granules. The structural and optical characterisation of the Ir(III) complexes together with SiO2 nanoparticles, nanosols (Ir@SiO2) and powders (Ir@SiO2 powders), revealed how the presence of the Ir(III)-based complexes did not alter the morphology of the colloidal silica or granulated phases. Moreover, the silica matrix did not interfere with the optical properties of the embedded complexes. The distribution of [F2IrPTZ-Me]+ and [IrQTZ-Me]+ in the spray-freeze-dried powders was qualitatively evaluated by fluorescence microscopy, revealing how the luminescent particles were homogeneously dispersed all over the silica matrix. Interestingly, in aqueous solution the release of complex [F2IrPTZ-Me]+ from the corresponding Ir@SiO2 powder is almost negligible, therefore suggesting that a strong interaction occurs between the host–silica matrix and the Ir(III) guest complex., This project has benefited from the EU-H2020 research program under grant agreement no. 654360 and has benefited from the access provided by the Fundacio Institut Català de Nanociència y Nanotecnologia – ICN2 – Barcelona (Spain) and the Foundation for Research and Technology Hellas – FORTH – Heraklion (Greece) within the framework of the NFFA-Europe Transnational Access Activity. The ICN2 is funded by the CERCA programme (Generalitat de Catalunya) and is supported by the Severo Ochoa programme of the Spanish Ministry of Economy, Industry and Competitiveness (MINECO, grant no. SEV-2013-0295). The authors wish to thank the Italian Ministry of Education, University and Research (MIUR) for their financial support (PRIN project: Towards a Sustainable Chemistry: Design of Innovative Metal–Ligand Systems for Catalysis and Energy Applications).
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- 2018
39. Highly twisted carbazole-borane derivatives: B–N stereodynamic analysis and consequences on their emission properties
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Michele Mancinelli, Simone Foschi, Stefano Stagni, Daniel Pecorari, Andrea Mazzanti, Stefano Gianvittorio, Valentina Fiorini, Pecorari, Daniel, Mazzanti, Andrea, Gianvittorio, Stefano, Foschi, Simone, Stagni, Stefano, Fiorini, Valentina, and Mancinelli, Michele
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chemistry.chemical_compound ,Crystallography ,chemistry ,carbazole-borane, stereodynamic, emission, B-N ,Carbazole ,Excited state ,Aryl ,Organic Chemistry ,Enantiomer ,Borane ,Boron atom ,Ground state ,Isomerization - Abstract
The stereodynamic properties of amino bis-mesityl-boranes bearing carbazole and benzocarbazole as donor heterocycles have been investigated by dynamic NMR analysis and simulated by DFT calculations. The π-contribution to the B–N bond has been estimated to be 24 kcal mol−1 when carbazole is the donor heterocycle, while a value of 21.7 kcal mol−1 has been found for the benzocarbazole series. Two rotational barriers were determined for the B–N bond, the lower one (11.1–16.9 kcal mol−1) leading to conformational enantiomers, and the higher one (21.0–24.0 kcal mol−1) likely being responsible for the E-Z isomerization in compounds bearing different aryl rings bound to the boron atom. It has been shown that both kinds of dynamic rearrangements involve a correlated motion of all the three rings. The difference in the ground state geometries and the different π-contributions led to pronounced variations in the fluorescence spectra, due to different geometric rearrangements in the TICT excited state. Stokes shifts larger than 10 000 cm−1 were observed in the carbazole series, with quantum yields up to 50%. It has been found that the π-contribution to the B–N bond in the excited state is still significant, with B–N isomerism likely not taking place on the ns scale.
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- 2021
40. Oxidative Coupling of Imino, Amide Platinum(II) Complexes Yields Highly Conjugated Blue Dimers
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Giovanni Talarico, Maria Elena Cucciolito, Francesco Ruffo, Roberto Esposito, Luisa Calvanese, Gabriella D'Auria, Prisco Pezzella, Valentina Fiorini, Stefano Stagni, Lucia Falcigno, Giuseppina Roviello, Esposito, Roberto, Calvanese, Luisa, Cucciolito, Maria Elena, D'Auria, Gabriella, Falcigno, Lucia, Fiorini, Valentina, Pezzella, Prisco, Roviello, Giuseppina, Stagni, Stefano, Talarico, Giovanni, Ruffo, Francesco, and Cucciolito, MARIA ELENA
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Olefin fiber ,010405 organic chemistry ,Organic Chemistry ,Optical measurements ,chemistry.chemical_element ,Nuclear magnetic resonance spectroscopy ,Conjugated system ,010402 general chemistry ,Photochemistry ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,Inorganic Chemistry, Platinum Complexes ,chemistry.chemical_compound ,chemistry ,Amide ,Molecule ,Oxidative coupling of methane ,Physical and Theoretical Chemistry ,Platinum - Abstract
Platinum(II) olefin compounds [PtMe(N,N′-imino, amide)(η2-olefin)] have been found to dimerize spontaneously in solution, yielding dinuclear complexes through an oxidative coupling. The extended conjugation within the molecules produces an intense blue color, and the properties of the compounds have been investigated through NMR spectroscopy, optical measurements, and theoretical calculations. The solid-state structure of a representative compound has been solved.
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- 2017
41. The stepwise generation of multimetallic complexes based on a vinylbipyridine linkage and their photophysical properties
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Andrew J. P. White, Jonathan A. Robson, Anita Toscani, Khairil A. Jantan, Jubeda B. Hena, Emily J. Parmenter, James D. E. T. Wilton-Ely, Valentina Fiorini, Stefano Stagni, Toscani, Anita, Jantan, Khairil A., Hena, Jubeda B., Robson, Jonathan A., Parmenter, Emily J., Fiorini, Valentina, White, Andrew J. P., Stagni, Stefano, and Wilton-Ely, James D. E. T.
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POLYAZOLYL CHELATE CHEMISTRY ,chemistry.chemical_element ,RUTHENIUM COMPLEXES, RHENIUM COMPLEXES, VINYL COMPLEXES, ELECTRONIC COMMUNICATION ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Inorganic Chemistry ,Metal ,chemistry.chemical_compound ,SIGMA-ORGANYL COMPLEXES ,0399 Other Chemical Sciences ,0302 Inorganic Chemistry ,Chemistry, Inorganic & Nuclear ,RICH BRIDGING UNITS ,Bifunctional ,Bimetallic strip ,MIXED-DONOR LIGANDS ,Science & Technology ,Quenching (fluorescence) ,010405 organic chemistry ,Chemistry ,Ligand ,DIYNE COORDINATION CHEMISTRY ,Rhenium ,GROUP-8 ALKYNYL COMPLEXES ,TRANSITION-METAL-COMPLEXES ,0104 chemical sciences ,Ruthenium ,Crystallography ,visual_art ,Physical Sciences ,visual_art.visual_art_medium ,BIMETALLIC RUTHENIUM COMPLEXES ,Inorganic & Nuclear Chemistry ,2 ALKENYL FRAGMENTS ,X-RAY-STRUCTURE ,Carbon monoxide - Abstract
The versatile rhenium complex [ReCl(CO)3(bpyC[triple bond, length as m-dash]CH)] (HC[triple bond, length as m-dash]Cbpy = 5-ethynyl-2,2'-bipyridine) is used to generate a series of bimetallic complexes through the hydrometallation of [MHCl(CO)(BTD)(PPh3)2] (M = Ru, Os; BTD = 2,1,3-benzothiadiazole). The ruthenium complex [Ru{CH[double bond, length as m-dash]CH-bpyReCl(CO)3}Cl(BTD)(CO)(PPh3)2] was characterised structurally. Ligand exchange reactions with bifunctional linkers bearing oxygen and sulfur donors provide access to tetra- and pentametallic complexes such as [{M{CH[double bond, length as m-dash]CH-bpyReCl(CO)3}(CO)(PPh3)2}2(S2CNC4H8NCS2)] and Fe[C5H4CO2M{CH[double bond, length as m-dash]CH-bpyReCl(CO)3}(CO)(PPh3)2]2. The effect of the group 8 metal on the photophysical properties of the rhenium centre was investigated using the complexes [Ru{CH[double bond, length as m-dash]CH-bpyReCl(CO)3}Cl(BTD)(CO)(PPh3)2] and [M{CH[double bond, length as m-dash]CH-bpyReCl(CO)3}{S2P(OEt)2}(CO)(PPh3)2] (M = Ru, Os). This revealed the quenching of the rhenium-based emission in favour of weak radiative processes based on the Ru and Os centres. The potential for exploiting this effect is illustrated by the reaction of [Ru{CH[double bond, length as m-dash]CH-bpyReCl(CO)3}Cl(CO)(BTD)(PPh3)2] with carbon monoxide, which results in a 5-fold fluorescence enhancement in the dicarbonyl product, [Ru{CH[double bond, length as m-dash]CH-bpyReCl(CO)3}Cl(CO)2(PPh3)2], as the quenching effect is disrupted.
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- 2017
42. Negatively charged Ir(<scp>iii</scp>) cyclometalated complexes containing a chelating bis-tetrazolato ligand: synthesis, photophysics and the study of reactivity with electrophiles
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Rita Mazzoni, Valentina Fiorini, Stefano Zacchini, Stefano Stagni, Paolo Raiteri, Valerio Zanotti, Massimiliano Massi, Fiorini, Valentina, Zacchini, Stefano, Raiteri, Paolo, Mazzoni, Rita, Zanotti, Valerio, Massi, Massimiliano, and Stagni, Stefano
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Luminescence ,Pyrazine ,010405 organic chemistry ,Ligand ,Stereochemistry ,Iridium complexe ,Protonation ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,soft salts, reacttivity, electrophiles ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,Deprotonation ,chemistry ,Electrophile ,Pyridine ,Tetrazolate ,Reactivity (chemistry) ,Tetrazole - Abstract
The bis-tetrazolate dianion [1,2 BTB](2-), which is the deprotonated form of 1,2 bis-(1H-tetrazol-5-yl)benzene [1,2-H2BTB], is for the first time exploited as an ancillary N^N ligand for negatively charged [Ir(C^N)2(N^N)](-)-type complexes, where C^N is represented by cyclometalated 2-phenylpyridine (ppy) or 2-(2,4-difluorophenyl)pyridine (F2ppy). The new Ir(iii) complexes [Ir(ppy)2(1,2 BTB)]- and [Ir(F2ppy)2(1,2 BTB)]- have been fully characterised and the analysis of the X-ray structure of [Ir(ppy)2(1,2 BTB)]- confirmed the coordination of the [1,2 BTB](2-) dianion in a bis chelated fashion through the N-atoms adjacent to each of the tetrazolic carbons. Both of the new anionic Ir(iii) complexes displayed phosphorescence in the visible region, with intense sky-blue (λmax = 460-490 nm) or aqua (λmax = 490-520 nm) emissions originating from [Ir(F2ppy)2(1,2 BTB)]- and [Ir(ppy)2(1,2 BTB)]-, respectively. In comparison with our very recent examples of anionic Ir(iii)tetrazolate cyclometalates, the new Ir(iii) tris chelate complexes [Ir(F2ppy)2(1,2 BTB)]- and [Ir(ppy)2(1,2 BTB)]-, display an improved robustness, allowing the study of their reactivity toward the addition of electrophiles such as H(+) and CH3(+). In all cases, the electrophilic attacks occurred at the coordinated tetrazolate rings, involving the reversible - by a protonation deprotonation mechanism - or permanent - upon addition of a methyl moiety - switching of their global net charge from negative to positive and, in particular, the concomitant variation of their photoluminescence output. The combination of the anionic complexes [Ir(F2ppy)2(1,2 BTB)]- or [Ir(ppy)2(1,2 BTB)]- with a deep red emitting (λmax = 686 nm) cationic Ir(iii) tetrazole complex such as [IrTPYZ-Me]+, where TPYZ-Me is 2-(2-methyl-2H-tetrazol-5-yl)pyrazine, gave rise to two fully Ir(iii)-based soft salts capable of displaying additive and O2-sensitive emission colours, with an almost pure white light obtained by the appropriate choice of the ionic components.
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- 2016
43. Luminescent protein staining with Re(i) tetrazolato complexes
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Nicola Monti, Stefano Stagni, Linda Bergamini, Massimiliano Massi, Valentina Fiorini, Alessandra Stefan, Alejandro Hochkoeppler, Sally E. Plush, Stefano Zacchini, Fiorini, Valentina, Bergamini, Linda, Monti, Nicola, Zacchini, Stefano, Plush, Sally E., Massi, Massimiliano, Hochkoeppler, Alejandro, Stefan, Alessandra, Stagni, Stefano, and Plush, Sally E
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endocrine system ,Luminescence ,Re(I) Complexes SDS-PAGE, proteins, luminescent staining ,Ovalbumin ,luminescent sensors ,Lactoglobulins ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,Inorganic Chemistry ,chemistry.chemical_compound ,Coordination Complexes ,Tetrazole ,Bovine serum albumin ,Polyacrylamide gel electrophoresis ,Aqueous solution ,biology ,L-Lactate Dehydrogenase ,010405 organic chemistry ,Chemistry ,Silver Staining Method ,Escherichia coli Proteins ,Cationic polymerization ,tetrazolato complexes ,Serum Albumin, Bovine ,beta-Galactosidase ,0104 chemical sciences ,Sulfonate ,Rhenium ,biology.protein ,Muramidase ,Phosphorescence ,Phenanthrolines - Abstract
Within the general framework of our past and current studies dealing with the investigation of the photophysical properties and the biological behavior of the family of tetrazolato and tetrazole Re(i) complexes, we have endeavored to investigate their potential in the luminescent staining of proteins purified by acrylamide gel electrophoresis. With the aim to provide the first examples of luminescent Re(i) complexes to be exploited for this specific purpose, we have designed and prepared four new Re(i)-based species with the general formula fac-[Re(CO)₃(N^N)(Tph)]²⁻/⁰, where Tph is the 5-(phenyl)tetrazolato anion and N^N is in turn represented by bathophenanthroline disulfonate (BPS), bathocuproine disulfonate (BCS) or by the SO₃-free bathocuproine (BC). In this latter case, the neutral complex fac-[Re(CO)₃(BC)(Tph)] served as a model species for the characterization of the former disulfonate complexes. Its cationic analogue fac-[Re(CO)₃(BC)(Tph-Me)]+was also prepared by a straightforward methylation reaction. All complexes displayed bright phosphorescence in organic media and, relative to their water solubility, the dianionic species fac-[Re(CO)₃(BPS)(Tph)]²⁻and fac-[Re(CO)₃(BCS)(Tph)]²⁻were also highly emissive in aqueous solution. The sulfonate groups played a key role in promoting and significantly enhancing the luminescent staining performances of both the Re(i) complexes fac-[Re(CO)₃(BPS)(Tph)]²⁻and fac-[Re(CO)₃(BCS)(Tph)]²⁻for proteins. Highlighting a response superior to that of Coomassie Blue and comparable to the one obtained by the well-known silver staining method, these dianionic Re(i)-complexes could efficiently detect up to 50 ng of pure Bovine Serum Albumin (BSA), as well as all proteins found in a Standard Protein Marker mix and from a total protein extract. A lower but still good response for luminescent protein staining was surprisingly obtained by employing the-SO₃-free neutral and cationic complexes fac-[Re(CO)₃(BC)(Tph)] and fac-[Re(CO)₃(BC)(Tph-Me)]+, respectively. These preliminary results open up new possibilities for the further widening of the use of Re(i)-based complexes as luminescent protein staining agents. Refereed/Peer-reviewed
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- 2018
44. Methylation of Ir(III)-tetrazolato complexes: An effective route to modulate the emission outputs and to switch to antimicrobial properties
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Alejandro Hochkoeppler, Massimiliano Massi, Stefano Zacchini, Anna Luisa Costa, Stefano Stagni, Valentina Fiorini, Anna Maria Ranieri, Alessandra Stefan, Ilaria Zanoni, Valerio Zanotti, Fiorini, Valentina, Zanoni, Ilaria, Zacchini, Stefano, Costa, ANNA LUISA, Hochkoeppler, Alejandro, Zanotti, Valerio, Ranieri, Anna Maria, Massi, Massimiliano, Stefan, Alessandra, and Stagni, Stefano
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Inorganic Chemistry, Iridium Complexes, Reactivity, Antibacterial properties, Luminescence, Deinococcus radiodurans, Escherichia coli ,Stereochemistry ,Molecular Conformation ,Tetrazoles ,010402 general chemistry ,Crystallography, X-Ray ,Iridium ,Ligands ,01 natural sciences ,Methylation ,Inorganic Chemistry ,chemistry.chemical_compound ,Anti-Infective Agents ,Coordination Complexes ,Disk Diffusion Antimicrobial Tests ,Escherichia coli ,Moiety ,Tetrazole ,biology ,010405 organic chemistry ,Chemistry ,Cationic polymerization ,Regioselectivity ,Deinococcus radiodurans ,Antimicrobial ,biology.organism_classification ,0104 chemical sciences ,Deinococcus ,Phosphorescence - Abstract
Two neutral cyclometalated Ir(III)-tetrazolato complexes that differ by variations of the substituents on either the phenylpyridine or the tetrazolate ligand have been converted into the corresponding methylated and cationic analogues. NMR (1H and 13C) characterization of the Ir(III) complexes provided the results in agreement with the chemo- and regioselective character of methylation at the N-3 position of the Ir(III)-coordinated tetrazolato ring. This evidence was further corroborated by the analysis of the molecular structures of the cationic complexes obtained by X-ray diffraction. In view of the photophysical properties, the addition of a methyl moiety to neutral Ir(III) tetrazolates, which behave as sky-blue or orange phosphors, caused a systematic red shift of their phosphorescence output. The transformation of neutral Ir(III) tetrazolates into cationic Ir(III)-tetrazole complexes was screened for any eventual antimicrobial activity in vitro against Gram negative (E. coli) and Gram positive (D. radiodurans) microorganisms. While both kinds of complexes were not active against E. coli, the conversion of the neutral Ir(III) tetrazolates into the corresponding methylated and cationic Ir(III)tetrazole derivatives determined the turn-on of a good to excellent antimicrobial activity toward Gram positive Deinococcus radiodurans, a non-pathogenic bacterium that is listed as one of the toughest microorganisms in light of its outstanding resistance to radiation and oxidative stress.
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- 2017
45. An area-based study on intrapartum antibiotic prophylaxis for preventing group B streptococcus early-onset disease: advances and limitations
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Luana Pini, Lucia Gambini, Alberto Berardi, Fabio Facchinetti, Irene Papa, Claudio Chiossi, Maria Grazia Capretti, Valentina Fiorini, Luigi Memo, Fabrizio Ferrari, Maria Letizia Bacchi Reggiani, Maria Vittoria Rizzo, Andrea Zucchini, Marcello Lanari, Cecilia Rossi, Annalisa Bastelli, Sara Gavioli, Berardi, Alberto, Rossi, Cecilia, Bacchi Reggiani, Maria Letizia, Bastelli, Annalisa, Capretti, Maria Grazia, Chiossi, Claudio, Fiorini, Valentina, Gambini, Lucia, Gavioli, Sara, Lanari, Marcello, Memo, Luigi, Papa, Irene, Pini, Luana, Rizzo, Maria Vittoria, Zucchini, Andrea, Facchinetti, Fabio, and Ferrari, Fabrizio
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medicine.medical_specialty ,Group B streptococcus ,Prom ,Group B ,sepsis ,03 medical and health sciences ,0302 clinical medicine ,prevention ,newborn ,Pregnancy ,Risk Factors ,intrapartum antibiotic prophylaxis ,risk factors ,030225 pediatrics ,Positive predicative value ,Streptococcal Infections ,Medicine ,Humans ,030212 general & internal medicine ,Antibiotic prophylaxis ,Full Term ,Retrospective Studies ,Group B streptococcu ,Receiver operating characteristic ,business.industry ,Obstetrics ,Rectum ,Obstetrics and Gynecology ,Odds ratio ,Antibiotic Prophylaxis ,Infectious Disease Transmission, Vertical ,Anti-Bacterial Agents ,Perinatal Care ,intrapartum antibiotic prophylaxi ,risk factor ,Pediatrics, Perinatology and Child Health ,Vagina ,Gestation ,Premature Birth ,Ampicillin ,Female ,Guideline Adherence ,business - Abstract
INTRODUCTION: The prevalence of maternal group-B-streptococcus (GBS) colonization and risk factors (RFs) for neonatal early-onset disease (EOD) in Europe are poorly defined. Large-scale information concerning adherence to recommendations for preventing GBS-EOD are lacking. MATERIALS AND METHODS: This was a 3-month retrospective area-based study including all regional deliveries ≥35 weeks' gestation (in 2012). The sensitivity, specificity, positive and negative predictive values, odds ratio and receiver operating characteristic (ROC) curve for intrapartum antibiotic prophylaxis (IAP) among full-term and preterm deliveries and prolonged membrane rupture (PROM) were calculated. RESULTS: Among 7133 women, 259 (3.6%) were preterm (35-36 weeks' gestation). Full-term women were 6874, and 876 (12.7%) had at least 1 RF. Most women (6495) had prenatal screening and 21.4% (1390) were GBS positive. IAP was given to 2369 (33.2%) women (preterm, n = 166; full term, n = 2203). Compared to full-term, preterm women were less likely to receive IAP when indicated (73.2% versus 90.3%, p
- Published
- 2016
46. Fully Ir(iii) tetrazolate soft salts: the road to white-emitting ion pairs
- Author
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Stefano Stagni, Karen D. M. MaGee, Mark I. Ogden, Valentina Fiorini, Andrea D'Ignazio, Massimiliano Massi, Fiorini, Valentina, D’Ignazio, Andrea, Magee, Karen D. M., Ogden, Mark I., Massi, Miliano, and Stagni, Stefano
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Luminescence ,White light: soft salts ,010405 organic chemistry ,Chemistry ,Inorganic chemistry ,Cationic polymerization ,Ion pairs ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,Ionic Iridium complexe ,Tetrazolate ligand ,Polymer chemistry ,Tetrazole ,Derivative (chemistry) - Abstract
The first examples of anionic Ir(iii) bis-tetrazolate complexes and their combination with a cationic Ir(iii)tetrazole derivative forming “fully tetrazolate” Ir(iii) based soft salts as O2-sensitive white emitters are described herein.
- Published
- 2016
47. Designing Ionic Ir(III) Cyclometalated Complexes as Photocatalysts for Light Assisted ATRP of MMA. A Combined Experimental and Mechanistic Study.
- Author
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Vigarani G, Marchini E, Previati E, Giorgini L, Zacchini S, Argazzi R, Massi M, Fiorini V, Caramori S, and Stagni S
- Abstract
A new family of ionic Ir(III) cyclometalated complexes with general formula [Ir(CN)
2 (NN)][Br], was designed and prepared to be assessed as photocalysts for the visible light assisted ATRP polymerization of MMA. To this purpose, our design strategy involved both: i) the decoration of the cyclometalating (CN) and the ancillary (NN) ligands with various electron withdrawing and/or electron donor substituents and, ii) the use of Br- as the counter anion for these cationic Ir(III) species. After an extensive screening in which the [Ir(CN)2 (NN)][Br]-type compounds were compared to the model neutral complex fac-[Ir(ppy)3 ], the "fully" amino-substituted ion pairs abbreviated as [10][Br] and [11][Br], exhibited the best photocatalytic performances under irradiation with CFL lamps. It is worth noting that the outcomes of transient absorption spectroscopy (TAS) experiments combined with theoretical DFT calculations, enlightened the role played by the Ir(III) complexes in the mechanism of the photoATRP process, and suggested the rationalization of the different performances that were highlighted by our Ir(III) catalyst in the visible light assisted photopolymerization of MMA., (© 2024 Wiley-VCH GmbH.)- Published
- 2024
- Full Text
- View/download PDF
48. Trapping an unprecedented octacoordinated iron(II) complex with neutral bis-tetrazolylpyridyl ligands and solvent molecules.
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Rigamonti L, Marchi L, Fiorini V, Stagni S, Zacchini S, Pinkowicz D, Dziedzic-Kocurek K, Forni A, Muniz Miranda F, and Mazzoni R
- Abstract
Iron(II) can show a very rich coordination chemistry with concomitant modulation of its properties as promising functional materials. Metalation of the neutral tridentate nitrogen-donor mer -coordinating ligand 2,6-bis(2-(methyl)-2 H -tetrazol-5-yl)pyridine (Me
2 btp) with Fe(ClO4 )2 ·6H2 O through accurate solvent polarity control enables the selective crystallization of [FeHS/LS (Me2 btp)2 ](ClO4 )2 ·MeCN·2.75H2 O (2HS/LS ·MeCN·2.75H2 O) as red rods, where half of the iron(II) centres resides in the low spin (LS, S = 0) state and the other half is in the high spin (HS, S = 2) state. The red rods spontaneously convert into yellow crystals once removed from the mother liquor and exposed to air due to solvent rearrangement within the crystal packing; these new crystals can be assigned to [FeHS (Me2 btp)2 ](ClO4 )2 ·solvent (2HS ·solvent) where all the iron(II) centres are now blocked in the HS state, as confirmed by magnetic measurements. The polarity of the crystallization solvent, together with the maintenance of the crystals within the mother liquor, are pivotal for the reactivity and interconversion of different species. Indeed, upon long standing in solution, 2HS/LS ·MeCN·2.75H2 O converts to another form of red crystals belonging to [FeLS (Me2 btp)2 ][FeHS (Me2 btp)(MeCN)2 (H2 O)](ClO4 )4 ·MeCN (2LS ·3HS ·MeCN), as confirmed by single crystal X-ray diffraction data. In this co-crystal, the iron(II) in 2 resides in the LS state at all temperatures while the iron(II) in 3 is blocked in the HS state. Well-formed yellow crystals could be also isolated among the red crystals of 2HS/LS ·MeCN·2.75H2 O, and they could be identified as the unprecedented octacoordinated species [Fe(Me2 btp)2 (MeCN)(H2 O)](ClO4 )2 ·H2 O (1·H2 O) by single-crystal X-ray diffraction. These yellow crystals are stable in the air, but slowly convert into 2LS ·3HS ·MeCN if kept in the mother liquor for about one week. 1·H2 O can be considered the trapped intermediate in the solid state during the conversion of [FeHS (Me2 btp)2 ]2+ into [FeHS (Me2 btp)(MeCN)2 (H2 O)]2+ in solution, where the two tridentate ligands in the starting species can unfold to accommodate coordinated MeCN and H2 O molecules, as confirmed by theoretical calculations, and eventually one of the two Me2 btp is completely replaced by the solvent.- Published
- 2024
- Full Text
- View/download PDF
49. Complementary Approaches to Imaging Subcellular Lipid Architectures in Live Bacteria Using Phosphorescent Iridium Complexes and Raman Spectroscopy.
- Author
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Ranieri AM, Caporale C, Fiorini V, Hubbard A, Rigby P, Stagni S, Watkin E, Ogden MI, Hackett MJ, and Massi M
- Subjects
- Coordination Complexes metabolism, Luminescent Agents chemistry, Spectrum Analysis, Raman, Bacillus cereus metabolism, Coordination Complexes chemistry, Iridium chemistry, Lipids chemistry, Microscopy, Confocal methods
- Abstract
A family of three neutral iridium(III) tetrazolato complexes are investigated as bacterial imaging agents. The complexes offer a facile tuning of the emission colour from green (520 nm) to red (600 nm) in aqueous media, while keeping the excitation wavelength unchanged. The three complexes do not inhibit the bacterial growth of Bacillus Cereus, used as a model in this study, and exhibit extremely fast cellular uptake. After a minute incubation time, the nontoxic complexes show subcellular localisation in spherical structures identified as lipid vacuoles. Confocal Raman imaging has been exploited for the first time on live bacteria, to provide direct and label-free mapping of the lipid-enriched organelles within B. cereus, complementing the use of luminescent probes. Examination of the Raman spectra not only confirmed the presence of lipophilic inclusions in B. cereus but offered additional information about their chemical composition, suggesting that the lipid vacuoles may contain polyhydroxybutyrate (PHB)., (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2019
- Full Text
- View/download PDF
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