Search

Your search keyword '"FERRARIO, FRANCO"' showing total 312 results
Start Over Author "FERRARIO, FRANCO"
312 results on '"FERRARIO, FRANCO"'

1. Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis

Author

Barbour, Sean J., Coppo, Rosanna, Er, Lee, Pillebout, Evangeline, Russo, Maria Luisa, Alpers, Charles E., Fogo, Agnes B., Ferrario, Franco, Jennette, J. Charles, Roberts, Ian S.D., Cook, H. Terence, Ding, Jie, Su, Baige, Zhong, Xuhui, Fervenza, Fernando C., Zand, Ladan, Peruzzi, Licia, Lucchetti, Laura, Katafuchi, Ritsuko, Shima, Yuko, Yoshikawa, Norishige, Ichikawa, Daisuke, Suzuki, Yusuke, Murer, Luisa, Wyatt, Robert J., Park, Catherine, Nelson, Raoul D., Narus, JoAnn H., Wenderfer, Scott, Geetha, Duvuru, Daugas, Eric, Monteiro, Renato C., Nakatani, Shinya, Mastrangelo, Antonio, Nuutinen, Matti, Koskela, Mikael, Weber, Lutz T., Hackl, Agnes, Pohl, Martin, Pecoraro, Carmine, Tsuboi, Nobuo, Yokoo, Takashi, Takafumi, Ito, Fujimoto, Shouichi, Conti, Giovanni, Santoro, Domenico, Materassi, Marco, Zhang, Hong, Shi, Sufang, Liu, Zhi-Hong, Tesar, Vladimir, Maixnerova, Dita, Avila-Casado, Carmen, Bajema, Ingeborg, Barreca, Antonella, Becker, Jan U., Comstock, Jessica M., Cornea, Virgilius, Eldin, Karen, Hernandez, Loren Herrera, Hou, Jean, Joh, Kensuke, Lin, Mercury, Messias, Nidia, Muda, Andrea Onetti, Pagni, Fabio, Diomedi-Camassei, Francesca, Tokola, Heikki, DʼArmiento, Maria, Seidl, Maximilian, Rosenberg, Avi, Sannier, Aurélie, Soares, Maria Fernanda, Wang, Suxia, Zeng, Caihong, and Haas, Mark

Published
2024
Full Text
View/download PDF

3. Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis

Author

Barbour, S, Coppo, R, Er, L, Pillebout, E, Russo, M, Alpers, C, Fogo, A, Ferrario, F, Jennette, J, Roberts, I, Cook, H, Ding, J, Su, B, Zhong, X, Fervenza, F, Zand, L, Peruzzi, L, Lucchetti, L, Katafuchi, R, Shima, Y, Yoshikawa, N, Ichikawa, D, Suzuki, Y, Murer, L, Wyatt, R, Nelson, R, Narus, J, Wenderfer, S, Geetha, D, Daugas, E, Monteiro, R, Nakatani, S, Mastrangelo, A, Nuutinen, M, Koskela, M, Weber, L, Hackl, A, Pohl, M, Pecoraro, C, Tsuboi, N, Yokoo, T, Takafumi, I, Fujimoto, S, Conti, G, Santoro, D, Materassi, M, Zhang, H, Shi, S, Liu, Z, Tesar, V, Maixnerova, D, Avila-Casado, C, Bajema, I, Barreca, A, Becker, J, Comstock, J, Cornea, V, Eldin, K, Hernandez, L, Hou, J, Joh, K, Lin, M, Messias, N, Muda, A, Pagni, F, Diomedi-Camassei, F, Tokola, H, D’Armiento, M, Seidl, M, Rosenberg, A, Sannier, A, Soares, M, Wang, S, Zeng, C, Haas, M, Barbour, Sean J., Coppo, Rosanna, Er, Lee, Pillebout, Evangeline, Russo, Maria Luisa, Alpers, Charles E., Fogo, Agnes B., Ferrario, Franco, Jennette, J. Charles, Roberts, Ian S. D., Cook, H. Terence, Ding, Jie, Su, Baige, Zhong, Xuhui, Fervenza, Fernando C., Zand, Ladan, Peruzzi, Licia, Lucchetti, Laura, Katafuchi, Ritsuko, Shima, Yuko, Yoshikawa, Norishige, Ichikawa, Daisuke, Suzuki, Yusuke, Murer, Luisa, Wyatt, Robert J., Nelson, Raoul D., Narus, JoAnn H., Wenderfer, Scott, Geetha, Duvuru, Daugas, Eric, Monteiro, Renato C., Nakatani, Shinya, Mastrangelo, Antonio, Nuutinen, Matti, Koskela, Mikael, Weber, Lutz T, Hackl, Agnes, Pohl, Martin, Pecoraro, Carmine, Tsuboi, Nobuo, Yokoo, Takashi, Takafumi, Ito, Fujimoto, Shouichi, Conti, Giovanni, Santoro, Domenico, Materassi, Marco, Zhang, Hong, Shi, Sufang, Liu, Zhi-Hong, Tesar, Vladimir, Maixnerova, Dita, Avila-Casado, Carmen, Bajema, Ingeborg, Barreca, Antonella, Becker, Jan U., Comstock, Jessica M., Cornea, Virgilius, Eldin, Karen, Hernandez, Loren Herrera, Hou, Jean, Joh, Kensuke, Lin, Mercury, Messias, Nidia, Muda, Andrea Onetti, Pagni, Fabio, Diomedi-Camassei, Francesca, Tokola, Heikki, D’Armiento, Maria, Seidl, Maximilian, Rosenberg, Avi, Sannier, Aurélie, Soares, Maria Fernanda, Wang, Suxia, Zeng, Caihong, Haas, Mark, Barbour, S, Coppo, R, Er, L, Pillebout, E, Russo, M, Alpers, C, Fogo, A, Ferrario, F, Jennette, J, Roberts, I, Cook, H, Ding, J, Su, B, Zhong, X, Fervenza, F, Zand, L, Peruzzi, L, Lucchetti, L, Katafuchi, R, Shima, Y, Yoshikawa, N, Ichikawa, D, Suzuki, Y, Murer, L, Wyatt, R, Nelson, R, Narus, J, Wenderfer, S, Geetha, D, Daugas, E, Monteiro, R, Nakatani, S, Mastrangelo, A, Nuutinen, M, Koskela, M, Weber, L, Hackl, A, Pohl, M, Pecoraro, C, Tsuboi, N, Yokoo, T, Takafumi, I, Fujimoto, S, Conti, G, Santoro, D, Materassi, M, Zhang, H, Shi, S, Liu, Z, Tesar, V, Maixnerova, D, Avila-Casado, C, Bajema, I, Barreca, A, Becker, J, Comstock, J, Cornea, V, Eldin, K, Hernandez, L, Hou, J, Joh, K, Lin, M, Messias, N, Muda, A, Pagni, F, Diomedi-Camassei, F, Tokola, H, D’Armiento, M, Seidl, M, Rosenberg, A, Sannier, A, Soares, M, Wang, S, Zeng, C, Haas, M, Barbour, Sean J., Coppo, Rosanna, Er, Lee, Pillebout, Evangeline, Russo, Maria Luisa, Alpers, Charles E., Fogo, Agnes B., Ferrario, Franco, Jennette, J. Charles, Roberts, Ian S. D., Cook, H. Terence, Ding, Jie, Su, Baige, Zhong, Xuhui, Fervenza, Fernando C., Zand, Ladan, Peruzzi, Licia, Lucchetti, Laura, Katafuchi, Ritsuko, Shima, Yuko, Yoshikawa, Norishige, Ichikawa, Daisuke, Suzuki, Yusuke, Murer, Luisa, Wyatt, Robert J., Nelson, Raoul D., Narus, JoAnn H., Wenderfer, Scott, Geetha, Duvuru, Daugas, Eric, Monteiro, Renato C., Nakatani, Shinya, Mastrangelo, Antonio, Nuutinen, Matti, Koskela, Mikael, Weber, Lutz T, Hackl, Agnes, Pohl, Martin, Pecoraro, Carmine, Tsuboi, Nobuo, Yokoo, Takashi, Takafumi, Ito, Fujimoto, Shouichi, Conti, Giovanni, Santoro, Domenico, Materassi, Marco, Zhang, Hong, Shi, Sufang, Liu, Zhi-Hong, Tesar, Vladimir, Maixnerova, Dita, Avila-Casado, Carmen, Bajema, Ingeborg, Barreca, Antonella, Becker, Jan U., Comstock, Jessica M., Cornea, Virgilius, Eldin, Karen, Hernandez, Loren Herrera, Hou, Jean, Joh, Kensuke, Lin, Mercury, Messias, Nidia, Muda, Andrea Onetti, Pagni, Fabio, Diomedi-Camassei, Francesca, Tokola, Heikki, D’Armiento, Maria, Seidl, Maximilian, Rosenberg, Avi, Sannier, Aurélie, Soares, Maria Fernanda, Wang, Suxia, Zeng, Caihong, and Haas, Mark

Abstract

BACKGROUND: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts. METHODS: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis ( N =361) from 23 centers in North America, Europe, and Asia were independently scored by three pathologists. MEST-C scores were assessed for correlation with eGFR/proteinuria at biopsy. Because most patients ( N =309, 86%) received immunosuppression, risk factors for outcomes were evaluated in this group using latent class mixed models to identify classes of eGFR trajectories over a median follow-up of 2.7 years (interquartile range, 1.2-5.1). Clinical and histologic parameters associated with each class were determined using logistic regression. RESULTS: M, E, T, and C scores were correlated with either eGFR or proteinuria at biopsy. Two classes were identified by latent class mixed model, one with initial improvement in eGFR followed by a late decline (class 1, N =91) and another with stable eGFR (class 2, N =218). Class 1 was associated with a higher risk of an established kidney outcome (time to ≥30% decline in eGFR or kidney failure; hazard ratio, 5.84; 95% confidence interval, 2.37 to 14.4). Among MEST-C scores, only E1 was associated with class 1 by multivariable analysis. Other factors associated with class 1 were age 18 years and younger, male sex, lower eGFR at biopsy, and extrarenal noncutaneous disease. Fibrous crescents without active changes were associated with class 2. CONCLUSIONS: Kidney outcome in patients with biopsied IgA vasculitis nephritis treated with immunosuppression was determined by clinical risk factors and endocapillary hypercellularity (E1) and fibrous crescents, which are features that are not part of the International Study of Diseases of Children classificatio

Published
2024

4. Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices

Author

Bajema, Ingeborg M., Wilhelmus, Suzanne, Alpers, Charles E., Bruijn, Jan A., Colvin, Robert B., Cook, H. Terence, D’Agati, Vivette D., Ferrario, Franco, Haas, Mark, Jennette, J. Charles, Joh, Kensuke, Nast, Cynthia C., Noël, Laure-Hélène, Rijnink, Emilie C., Roberts, Ian S.D., Seshan, Surya V., Sethi, Sanjeev, and Fogo, Agnes B.

Published
2018
Full Text
View/download PDF

6. Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group

Author

Alpers, Charles E., Asunis, Ana María, Barbour, Sean, Becker, Jan U., Ding, Jie, Espino, Gabriella, Ferrario, Franco, Fogo, Agnes, Hladunewich, Michelle, Joh, Kensuke, Katafuchi, Ritsuko, Lv, Jicheng, Matsuzaki, Keiichi, Nakanishi, Koichi, Pani, Antonello, Perera, Ran, Perkowska-Ptasinska, Agnieszka, Reich, Heather, Shima, Yuko, Soares, Maria Fernanda, Suzuki, Yusuke, Takahashi, Katsuo, Troyanov, Stéphan, Verhave, Jacobien C., Wang, Suxia, Weening, Jan, Wyatt, Robert, Yoshikawa, Nori, Zeng, Caihong, Trimarchi, Hernán, Barratt, Jonathan, Cattran, Daniel C., Cook, H. Terence, Coppo, Rosanna, Haas, Mark, Liu, Zhi-Hong, Roberts, Ian S.D., Yuzawa, Yukio, Zhang, Hong, and Feehally, John

Published
2017
Full Text
View/download PDF

7. Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy

Author

Alpers, Charles E., Amore, Alessandro, Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., Cattran, Daniel C., Coppo, Rosanna, D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven, Emma, Francesco, Feehally, John, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes, Geddes, Colin C., Groene, Hermann-Josef, Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hogg, Ronald J., Hsu, Stephen I., Jennette, J. Charles, Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Li, Lei-Shi, Li, Philip K.T., Liu, Zhi-Hong, Mackinnon, Bruce, Mezzano, Sergio, Schena, F. Paolo, Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Nori, Zhang, Hong, Bellur, Shubha S., Lepeytre, Fanny, Vorobyeva, Olga, Troyanov, Stéphan, Cook, H. Terence, and Roberts, Ian S.D.

Published
2017
Full Text
View/download PDF

8. Lupus Nephritis

Author

Pani, Antonello, Angioi, Andrea, Ferrario, Franco, Emmi, Lorenzo, Series editor, Prisco, Domenico, Series editor, and Roccatello, Dario, editor

Published
2016
Full Text
View/download PDF

10. Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments

Author

Coppo, Rosanna, Troyanov, Stéphan, Bellur, Shubha, Cattran, Daniel, Cook, H. Terence, Feehally, John, Roberts, Ian S.D., Morando, Laura, Camilla, Roberta, Tesar, Vladimir, Lunberg, Sigrid, Gesualdo, Loreto, Emma, Francesco, Rollino, Cristiana, Amore, Alessandro, Praga, Manuel, Feriozzi, Sandro, Segoloni, Giuseppe, Pani, Antonello, Cancarini, Giovanni, Durlik, Magalena, Moggia, Elisabetta, Mazzucco, Gianna, Giannakakis, Costantinos, Honsova, Eva, Sundelin, B. Brigitta, Di Palma, Anna Maria, Ferrario, Franco, Gutierrez, Eduardo, Asunis, Anna Maria, Barratt, Jonathan, Tardanico, Regina, Perkowska-Ptasinska, Agnieszka, and on behalf of the VALIGA study of the ERA-EDTA Immunonephrology Working Group

Published
2014
Full Text
View/download PDF

12. Risk factors for progression in children and young adults with IgA nephropathy: an analysis of 261 cases from the VALIGA European cohort

Author

Coppo, Rosanna, Lofaro, Danilo, Camilla, Roberta R, Bellur, Shubha, Cattran, Daniel, Cook, H. Terence, Roberts, Ian S. D., Peruzzi, Licia, Amore, Alessandro, Emma, Francesco, Fuiano, Laura, Berg, Ulla, Topaloglu, Rezan, Bilginer, Yelda., Gesualdo, Loreto, Polci, Rosaria, Mizerska-Wasiak, Malgorzata, Caliskan, Yasar, Lundberg, Sigrid, Cancarini, Giovanni, Geddes, Colin, Wetzels, Jack, Wiecek, Andrzej, Durlik, Magdalena, Cusinato, Stefano, Rollino, Cristiana, Maggio, Milena, Praga, Manuel, K.Smerud, Hilde, Tesar, Vladimir, Maixnerova, Dita, Barratt, Jonathan, Papalia, Teresa, Bonofiglio, Renzo, Mazzucco, Gianna, Giannakakis, Costantinos, Soderberg, Magnus, Orhan, Diclehan, Di Palma, Anna Maria, Maldyk, Jadwiga, Ozluk, Yasemin, Sudelin, Birgitta, Tardanico, Regina, Kipgen, David, Steenbergen, Eric, Karkoszka, Henryk, Perkowska-Ptasinska, Agnieszka, Ferrario, Franco, Gutierrez, Eduardo, and Honsova, Eva

Published
2017
Full Text
View/download PDF

13. Dissecting the histological features of lupus nephritis highlights new common patterns of injury in class III/IV

Author

Bolognesi, Maddalena Maria, primary, Capitoli, Giulia, additional, Galimberti, Stefania, additional, Cattoretti, Giorgio, additional, Bajema, Ingeborg, additional, Bruijn, Jan A, additional, Cook, H Terence, additional, Noel, Laure-Helene, additional, Pagni, Fabio, additional, Ferrario, Franco, additional, Wester Trejo, Maria, additional, and L'Imperio, Vincenzo, additional

Published
2022
Full Text
View/download PDF

14. Dissecting the histological features of lupus nephritis highlights new common patterns of injury in class III/IV

Author

Bolognesi, M, Capitoli, G, Galimberti, S, Cattoretti, G, Bajema, I, Bruijn, J, Cook, H, Noel, L, Pagni, F, Ferrario, F, Wester Trejo, M, L'Imperio, V, Bolognesi, Maddalena Maria, Capitoli, Giulia, Galimberti, Stefania, Cattoretti, Giorgio, Bajema, Ingeborg, Bruijn, Jan A, Cook, H Terence, Noel, Laure-Helene, Pagni, Fabio, Ferrario, Franco, Wester Trejo, Maria, L'Imperio, Vincenzo, Bolognesi, M, Capitoli, G, Galimberti, S, Cattoretti, G, Bajema, I, Bruijn, J, Cook, H, Noel, L, Pagni, F, Ferrario, F, Wester Trejo, M, L'Imperio, V, Bolognesi, Maddalena Maria, Capitoli, Giulia, Galimberti, Stefania, Cattoretti, Giorgio, Bajema, Ingeborg, Bruijn, Jan A, Cook, H Terence, Noel, Laure-Helene, Pagni, Fabio, Ferrario, Franco, Wester Trejo, Maria, and L'Imperio, Vincenzo

Abstract

Objective: The International Society of Nephrology/Renal Pathology Society classification is the gold standard for the characterisation of lupus nephritis (LN) on renal biopsy, with therapeutic repercussions. Its recent revision simplified the current class subdivisions, eliminating the S/G forms of class IV, although data on a possible pathogenetic/clinical value of this subdivision are still contradictory. Methods: 353 renal biopsies from Belimumab International Study in LN were assessed through central pathology review. Univariate logistic models and a decision tree were performed on 314 adequate biopsies to evaluate the impact of histological features on focal/diffuse classes. Removing class I/II (n=6) and € pure' class V (n=34), principal component analysis (PCA) and heatmap were used to explore similarities among III, IVS and IVG biopsies either incorporating or not the mixed classes (+V, n=274). Finally, a method aimed at partitioning the cases into k clusters based on their similarity (KMeans), was used to study features from the cohort of € pure' class III/IVS/IVG cases (n=214) to determine alternative subdivisions based on phenotypic data. Results: Segmental endocapillary hypercellularity (EH) was prevalent in class III, global EH, wire loops, hyaline thrombi and double contours were hallmarks of class IVG, with IVS cases showing intermediate characteristics. Heatmap and PCA confirmed the segregation of these features among classes, showing better segregation for focal/diffuse LN as compared with the mixed classes (+V). KMeans revealed the presence of two main clusters, membranoproliferative-like (n=83) or vasculitis-like (n=131). Conclusions: This study reveals new phenotypic forms of LN surpassing the traditional classes as determined by the current classification. Future validation and confirmation are required to confirm these findings.

Published
2022

16. The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults

Author

Coppo, Rosanna, Troyanov, Stéphan, Camilla, Roberta, Hogg, Ronald J., Cattran, Daniel C., Terence Cook, H., Feehally, John, Roberts, Ian S.D., Amore, Alessandro, Alpers, Charles E., Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven N., Emma, Francesco, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes B., Geddes, Colin C., Groene, Hermann J., Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hsu, Stephen I., Charles Jennette, J., Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Li, Lei S., Li, Philip K., Liu, Zhi H., Mezzano, Sergio, Paolo Schena, F., Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Norishige, and Zhang, Hong

Published
2010
Full Text
View/download PDF

18. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification

Author

A Working Group of the International IgA Nephropathy Network and the Renal Pathology Society, Cattran, Daniel C., Coppo, Rosanna, Cook, H. Terence, Feehally, John, Roberts, Ian S.D., Troyanov, Stéphan, Alpers, Charles E., Amore, Alessandro, Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven, Emma, Francesco, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes, Geddes, Colin C., Groene, Hermann-Josef, Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hogg, Ronald J., Hsu, Stephen I., Jennette, J. Charles, Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Leung, Chi Bon, Li, Lei-Shi, Li, Philip K.T., Liu, Zhi-Hong, Mackinnon, Bruce, Mezzano, Sergio, Schena, F. Paolo, Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Nori, and Zhang, Hong

Published
2009
Full Text
View/download PDF

19. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility

Author

A Working Group of the International IgA Nephropathy Network and the Renal Pathology Society, Roberts, Ian S.D., Cook, H. Terence, Troyanov, Stéphan, Alpers, Charles E., Amore, Alessandro, Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., Cattran, Daniel C., Coppo, Rosanna, D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven, Emma, Francesco, Feehally, John, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes, Geddes, Colin C., Groene, Hermann-Josef, Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hogg, Ronald J., Hsu, Stephen I., Jennette, J. Charles, Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Li, Lei-Shi, Li, Philip K.T., Liu, Zhi-Hong, Mackinnon, Bruce, Mezzano, Sergio, Schena, F. Paolo, Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Nori, and Zhang, Hong

Published
2009
Full Text
View/download PDF

20. Renal function and ear, nose, throat involvement in anti-neutrophil cytoplasmic antibody-associated vasculitis: prospective data from the European Vasculitis Society clinical trials

Author

Rahmattulla, Chinar, de Lind van Wijngaarden, Robert A. F., Berden, Annelies E., Hauer, Herbert A., Flomann, Oliver, Jayne, David R. W., Gaskin, Gill, Rasmussen, Niels, Noël, Laure-Hélène, Ferrario, Franco, Waldherr, Rüdiger, Wolterbeek, Ron, Göçeroğlu, Arda, Pusey, Charles D., Hagen, E. Christiaan, Bruijn, Jan A., and Bajema, Ingeborg M.

Published
2015
Full Text
View/download PDF

24. Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy

Author

Verzola, Daniela, Gandolfo, Maria Teresa, Gaetani, Gianfranco, Ferraris, Annamaria, Mangerini, Rosa, Ferrario, Franco, Villaggio, Barbara, Gianiorio, Fabio, Tosetti, Fanny, Weiss, Ursula, Traverso, Paolo, Mji, Mariano, Deferrari, Giacomo, and Garibotto, Giacomo

Subjects
Aging -- Influence, Type 2 diabetes -- Complications and side effects, Diabetic nephropathies -- Complications and side effects, Biological sciences
Abstract

We examined the hypothesis that senescence represents a proximate mechanism by which the kidney is damaged in type 2 diabetic nephropathy (DN). As a first step, we studied whether the senescence-associated [beta]-galactosidase (SA-[beta]-Gal) and the cell cycle inhibitor [p16.sup.INK4A] are induced in renal biopsies from patients with type 2 DN. SA-[beta]-Gal staining was approximately threefold higher (P < 0.05) than in controls in the tubular compartment of diabetic kidneys and correlated directly with body mass index and blood glucose. [P16.sup.INK4A] expression was significantly increased in tubules (P < 0.005) and in podocytes (P = 0.04). Nuclear [p16.sup.INK4A] in glomeruli was associated with proteinuria (P < 0.002), while tubular [p16.sup.INK4A] was directly associated with body mass index, LDL cholesterol, and HbAlc (P < 0.001-0.05). In a parallel set of experiments, proximal tubule cells passaged under high glucose presented a limited life span and an approximately twofold increase in SA-[beta]-Gal and [p16.sup.INK4A] protein. Mean telomere lengths decreased ~20% as an effect of replicative senescence. In addition, mean telomere decreased further by ~30% in cells cultivated under high glucose. Our results show that the kidney with type 2 diabetic nephropathy displays an accelerated senescent phenotype in defined renal cell types, mainly tubule cells and, to a lesser extent, podocytes. A similar senescent pattern was observed when proximal tubule cell cultures where incubated under high-glucose media. These changes are associated with shortening tubular telomere length in vitro. These findings indicate that diabetes may boost common pathways involving kidney cell senescence, thus reinforcing the role of the metabolic syndrome on biological aging of tissues. tubular cells; telomeres; [p16.sup.INK4A]; senescence-associated [beta]-galactosidase

Published
2008

25. Erratum to: Risk factors for progression in children and young adults with IgA nephropathy: an analysis of 261 cases from the VALIGA European cohort

Author

Coppo, Rosanna, Lofaro, Danilo, Camilla, Roberta R., Bellur, Shubha, Cattran, Daniel, Cook, H. Terence, Roberts, Ian S. D., Peruzzi, Licia, Amore, Alessandro, Emma, Francesco, Fuiano, Laura, Berg, Ulla, Topaloglu, Rezan, Bilginer, Yelda, Gesualdo, Loreto, Polci, Rosaria, Mizerska-Wasiak, Malgorzata, Caliskan, Yasar, Lundberg, Sigrid, Cancarini, Giovanni, Geddes, Colin, Wetzels, Jack, Wiecek, Andrzej, Durlik, Magdalena, Cusinato, Stefano, Rollino, Cristiana, Maggio, Milena, Praga, Manuel, Smerud, Hilde K., Tesar, Vladimir, Maixnerova, Dita, Barratt, Jonathan, Papalia, Teresa, Bonofiglio, Renzo, Mazzucco, Gianna, Giannakakis, Costantinos, Soderberg, Magnus, Orhan, Diclehan, Di Palma, Anna Maria, Maldyk, Jadwiga, Ozluk, Yasemin, Sudelin, Birgitta, Tardanico, Regina, Kipgen, David, Steenbergen, Eric, Karkoszka, Henryk, Perkowska-Ptasinska, Agnieszka, Ferrario, Franco, Gutierrez, Eduardo, and Honsova, Eva

Published
2017
Full Text
View/download PDF

30. Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis

Author

Bertsias, George K, Tektonidou, Maria, Amoura, Zahir, Aringer, Martin, Bajema, Ingeborg, Berden, Jo H M, Boletis, John, Cervera, Ricard, Dörner, Thomas, Doria, Andrea, Ferrario, Franco, Floege, Jürgen, Houssiau, Frederic A, Ioannidis, John P A, Isenberg, David A, Kallenberg, Cees G M, Lightstone, Liz, Marks, Stephen D, Martini, Alberto, Moroni, Gabriela, Neumann, Irmgard, Praga, Manuel, Schneider, Matthias, Starra, Argyre, Tesar, Vladimir, Vasconcelos, Carlos, van Vollenhoven, Ronald F, Zakharova, Helena, Haubitz, Marion, Gordon, Caroline, Jayne, David, and Boumpas, Dimitrios T

Published
2012
Full Text
View/download PDF

31. Developments in the Histopathological Classification of ANCA-Associated Glomerulonephritis

Author

van Daalen, Emma E., primary, Wester Trejo, Maria A.C., additional, Göçeroğlu, Arda, additional, Ferrario, Franco, additional, Joh, Kensuke, additional, Noël, Laure-Hélène, additional, Ogawa, Yayoi, additional, Wilhelmus, Suzanne, additional, Ball, Miriam J., additional, Honsova, Eva, additional, Hruskova, Zdenka, additional, Kain, Renate, additional, Kimura, Tomoyoshi, additional, Kollar, Marek, additional, Kronbichler, Andreas, additional, Lindhard, Kristine, additional, Puéchal, Xavier, additional, Salvatore, Steven, additional, Szpirt, Wladimir, additional, Takizawa, Hideki, additional, Tesar, Vladimir, additional, Berden, Annelies E., additional, Dekkers, Olaf M., additional, Hagen, E. Christiaan, additional, Oosting, Jan, additional, Rahmattulla, Chinar, additional, Wolterbeek, Ron, additional, Bos, Willem Jan, additional, Bruijn, Jan A., additional, and Bajema, Ingeborg M., additional

Published
2020
Full Text
View/download PDF

35. Pathologic Classification of Diabetic Nephropathy

Author

Tervaert, Thijs W. Cohen, Mooyaart, Antien L., Amann, Kerstin, Cohen, Arthur H., Cook, H. Terence, Drachenberg, Cinthia B., Ferrario, Franco, Fogo, Agnes B., Haas, Mark, de Heer, Emile, Joh, Kensuke, Noël, Laure H., Radhakrishnan, Jai, Seshan, Surya V., Bajema, Ingeborg M., and Bruijn, Jan A.

Published
2010
Full Text
View/download PDF

37. Clinical and Histologic Determinants of Renal Outcome in ANCA-Associated Vasculitis: A Prospective Analysis of 100 Patients with Severe Renal Involvement

Author

de Lind van Wijngaarden, Robert A.F., Hauer, Herbert A., Wolterbeek, Ron, Jayne, David R.W., Gaskin, Gill, Rasmussen, Niels, Noe[Combining Diaeresis]l, Laure-He[Combining Acute Accent]le[Combining Grave Accent]ne, Ferrario, Franco, Waldherr, Ru[Combining Diaeresis]diger, Hagen, E. Christiaan, Bruijn, Jan A., and Bajema, Ingeborg M.

Published
2006
Full Text
View/download PDF

45. The classification of glomerulonephritis in systemic lupus erythematosus revisited

Author

Weening, Jan J., D'agati, Vivette D., Schwartz, Melvin M., Seshan, Surya V., Alpers, Charles E., Appel, Gerald B., Balow, James E., Bruijn, J.A.N. A., Cook, Terence, Ferrario, Franco, Fogo, Agnes B., Ginzler, Ellen M., Hebert, Lee, Hill, Gary, Hill, Prue, Jennette, J. Charles, Kong, Norella C., Lesavre, Philippe, Lockshin, Michael, Looi, Lai-Meng, Makino, Hirofumi, Moura, Luiz A., Nagata, Michio, and ON Behalf of the International Society of Nephrology and Renal Pathology Society Working Group on the Classification Oflupus Nephritis

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results