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Eosinophilic granulomatosis with polyangiitis, formerly called Churg-Strauss syndrome, is characterized by asthma, peripheral blood eosinophilia and eosinophilic tissue infiltration, extravascular granulomas, and vasculitis of multiple organ systems. It is a rare vasculitis with incidence of 1 to 3 cases in 1 million people / year and discrete female predominance (1,2:1). In this study, we report the case of a 47-year-old male patient who presented an ascending paresthesia, intense pain and petechiae in the lower limbs. He had a history of late-onset asthma and important eosinophilia. Computed Tomography (CT) of the face revealed pansinusopathy and chest CT showed nodular opacities in ground glass, as well as opacities with peripheral distribution. Skin biopsy showed medium-sized vasculitis. Therefore, the diagnosis of eosinophilic granulomatosis with polyangiitis was confirmed and a proposed treatment with glucocorticoids and analgesics was administered. Although rare, eosinophilic granulomatosis with polyangiitis should be suspected in all patients with severe refractory asthma, as well as in patients with unexplained neuropathy and eosinophilia. Early diagnosis and treatment are closely related to improvement in quality of life and overall reduction of morbidity and mortality. [ABSTRACT FROM AUTHOR]