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1. Marital status and long-term cardiovascular risk in general population—RIFLE project (Italy).

Author

Rabiaza, Andry, Puddu, Paolo E., Menotti, Alessandro, Humbert, Xavier, Menotti, A., Farchi, G., Alessandrini, P., Ambrosio, G. B., Angelico, F., Antonini, R., Attili, F. A., Avellone, G., Bittolo-Bon, G., Bucci, A., Buzzelli, G. B., DePretis, G., Dobrilla, G., Dormi, A., Farinaro, E., and Ferrario, M.

Abstract

Background: The impact of marital status on cardiovascular disease (CVD) remains controversial in the general population. Aim: The present investigation sought to delineate the association between marital status and long-term major non-fatal and fatal CVD, along with all-cause mortality within the scope of the RIFLE project (Risk Factors and Life Expectancy). Methods: We examined the incidences of CVD, including cerebrovascular accidents and coronary heart disease (CHD), as well as all-cause mortality. In total, 47,167 individuals (46% female, average age 50 ± 9 years) were included in the analysis. Marital status at inception was categorized into married (inclusive of married or cohabitating) versus unmarried cohorts (including widowed, separated, divorced, or single individuals). Results: Compared to their married counterparts, unmarried subjects demonstrated a heightened risk for CVD in both females and males. Throughout a median follow-up span of 7.4 years (interquartile range from 6 to 9 years), married participants, adjusting for standard risk factors, exhibited reduced mortality rates attributed to CHD [hazard ratio (HR) 0.54 (95% confidence interval (CI) 0.33–0.86)) and all causes (HR 0.75 (95% CI 0.62–0.91)] within the aggregate population; this reduction persisted for both CHD-specific [HR 0.39 (95% CI 0.51–0.90)]and all-cause mortality [HR 0.68 (95% CI 0.51–0.90)], independent of traditional risk factors in women. No associations were evident between matrimonial status and any measured outcomes in males. Conclusions: Within primary care settings, marital status should be considered a potential correlate of long-term CHD and overall mortality risks, especially among women. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging

Author

Scafato, E., Farchi, G., Galluzzo, L., Gandin, C., Capurso, A., Panza, F., Solfrizzi, V., Lepore, V., Livrea, P., Motta, L., Carnazzo, G., Motta, M., Bentivegna, P., Bonaiuto, S., Cruciani, G., Postacchini, D., Inzitari, D., Amaducci, L., Di Carlo, A., Baldereschi, M., Gandolfo, C., Conti, M., Canal, N., Franceschi, M., Scarlato, G., Candelise, L., Scapini, E., Rengo, F., Abete, P., Cacciatore, F., Enzi, G., Battistin, L., Sergi, G., Crepaldi, G., Maggi, S., Minicucci, N., Noale, M., Grigoletto, F., Perissinotto, E., Carbonin, P., Solfrizzi, Vincenzo, Scafato, Emanuele, Lozupone, Madia, Seripa, Davide, Giannini, Michele, Sardone, Rodolfo, Bonfiglio, Caterina, Abbrescia, Daniela I., Galluzzo, Lucia, Gandin, Claudia, Baldereschi, Marzia, Di Carlo, Antonio, Inzitari, Domenico, Daniele, Antonio, Sabbà, Carlo, Logroscino, Giancarlo, and Panza, Francesco

Published
2017
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4. Associations between cardiac arrhythmia, incident disability in activities of daily living and physical performance: The ilsa study

Author

Noale, M., Veronese, N., Smith, L., Ungar, A., Fumagalli, S., Maggi, S., Scafato, E., Farchi, G., Galluzzo, L., Gandin, C., Capurso, A., Panza, F., Solfrizzi, V., Lepore, V., Livrea, P., Motta, L., Car-Nazzo, G., Motta, M., Bentivegna, P., Bonaiuto, S., Cruciani, G., Postacchini, D., Inzitari, D., Amaducci, L., Di Carlo, A., Baldereschi, M., Gandolfo, C., Conti, M., Canal, N., Franceschi, M., Scarlato, G., Candelise, L., Scapini, E., Rengo, F., Abete, P., Cacciatore, F., Enzi, G., Battistin, L., Sergi, G., Crepaldi, G., Minicuci, N., Grigoletto, F., Perissinotto, E., Carbonin, P., Noale, M., Veronese, N., Smith, L., Ungar, A., Fumagalli, S., Maggi, S., Scafato, E., Farchi, G., Galluzzo, L., Gandin, C., Capurso, A., Panza, F., Solfrizzi, V., Lepore, V., Livrea, P., Motta, L., Car-Nazzo, G., Motta, M., Bentivegna, P., Bonaiuto, S., Cruciani, G., Postacchini, D., Inzitari, D., Amaducci, L., Di Carlo, A., Baldereschi, M., Gandolfo, C., Conti, M., Canal, N., Franceschi, M., Scarlato, G., Candelise, L., Scapini, E., Rengo, F., Abete, P., Cacciatore, F., Enzi, G., Battistin, L., Sergi, G., Crepaldi, G., Minicuci, N., Grigoletto, F., Perissinotto, E., and Carbonin, P.

Subjects
Disability, Physical activity, Atrial fibrillation, Cardiac arrhythmia, not known, Physical performance
Abstract

Background Cardiac arrhythmias are common conditions in older people. Unfortunately, there is limited literature on associations between cardiac arrhythmias and physical performance or disability. We therefore aimed to prospectively investigate associations between cardiac arrhythmias and changes in disability and physical performance during 8 years of follow-up, using data from the Italian Longitudinal Study on Aging (ILSA). Methods Cardiac arrhythmias diagnosis was posed through a screening phase, confirmed by a physician. The onset of disability in activities of daily living (ADL) and the changes in several physical performance tests during follow-up were considered as outcomes. Fully-adjusted and propensity-score Cox Proportional Hazard models and mixed models were used for exploring associations between cardiac arrhythmia and the outcomes of interest. Results The prevalence of cardiac arrhythmia at baseline was 23.3%. People reporting cardiac arrhythmia at the baseline were significantly older, more frequently male, smokers and reported a higher presence of all medical conditions investigated (hypertension, heart failure, angina, myocardial infarction, diabetes, stroke), but no difference in dementia, Parkinsonism, cognitive or mood disorder. Cardiac arrhythmia at baseline was significantly associated with the incidence of disability in ADL (HR = 1.23; 95%: CI: 1.01-1.50; P = 0.0478 in propensity score analyses; HR = 1.28; 95% CI: 1.01-1.61; P = 0.0401 in fully adjusted models). Cardiac arrhythmia at baseline was also associated with a significant worsening in balance test (P = 0.0436). Conclusions The presence of cardiac arrhythmia at baseline was associated with a significant higher risk of disability and of worsening in some physical performance tests, particularly those relating to balance. Screening and frequently assessing physical performance in older people affected by cardiac arrhythmia can be important to prevent a loss of physical performance, with further, potential, complications of medical management. © 2020 JGC All rights reserved

Published
2020

7. Relationship between eating patterns meeting recommendations and subsequent mortality in 20 years

Author

Farchi, G., Fidanza, F., Grossi, P., Lancia, A., Mariotti, S., and Menotti, A.

Subjects
Diseases -- Causes and theories of causation, Diet in disease -- Research, Men -- Food and nutrition, Mortality -- Research, Food habits -- Health aspects
Abstract

Proper nutrition has been known to significantly increase the cure rate and decrease the risk of various diseases, including coronary heart disease, cerebrovascular disease, diabetes and various types of cancer. Nutritionists have come up with dietary recommendations to guide people on the proper kinds and amounts of food to eat. However, further study is needed to assess the impact of dietary recommendations on mortality.

Published
1995

9. Is diet an independent risk factor for mortality? 20 year mortality in the Italian rural cohorts of the Seven Countries Study

Author

Farchi, G., Fidanza, F., Mariotti, S., and Menotti, A.

Subjects
Heart diseases -- Case studies, Diet -- Health aspects, Mortality -- Risk factors
Abstract

A survey conducted on 1,563 men, aged between 45 and 62, to analyze the factors affecting heart disease and understand the effect of diet on mortality, revealed that various dietary schedules carried varying survival probabilities. Optimum diet schemes with a low mortality figure allowed more than 2,800 kilocalories per day.

Published
1994

11. Incidence of dementia: evidence for an effect modification by gender. The ILSA Study

Author

Noale M., Limongi F, Zambon S, Crepaldi G. Maggi S, Scafato E, Farchi G, Galluzzo L, Gandin C, Capurso A, Panza F, Solfrizzi V, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Perissinotto E, Carbonin P, Crepaldi G, Maggi S, Carnazzo, G, Inzitari D, Amaducci L, Di Carlo A, Baldereschi M, Gandolfo C, Conti M, Canal N, Franceschi M, Scarlato G, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Minicuci N, Noale M, Grigoletto F, Perissinotto E., Noale, M., Limongi, F, Zambon, S, Crepaldi G., Maggi S, Scafato, E, Farchi, G, Galluzzo, L, Gandin, C, Capurso, A, Panza, F, Solfrizzi, V, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Perissinotto, E, Carbonin, P, Crepaldi, G, Maggi, S, Inzitari, D, Amaducci, L, Di Carlo, A, Baldereschi, M, Gandolfo, C, Conti, M, Canal, N, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Minicuci, N, Noale, M, Grigoletto, F, and Perissinotto, E.

Subjects
Male, Longitudinal study, medicine.medical_specialty, Lower risk, Body Mass Index, Sex Factors, Risk Factors, medicine, Humans, Dementia, Longitudinal Studies, Family history, Psychiatry, Aged, Proportional Hazards Models, Aged, 80 and over, Depression, Proportional hazards model, business.industry, Incidence, Incidence (epidemiology), Age Factors, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Educational Status, Population study, Female, Geriatrics and Gerontology, business, Gerontology, Demography, Cohort study
Abstract

Background:Gender differences for incidence of dementia among elderly people have been usually investigated considering gender as a predictor and not as a stratification variable.Methods:Analyses were based on data collected by the Italian Longitudinal Study on Aging (ILSA), which enrolled 5,632 participants aged 65–84 years between 1992 and 2000. During a median follow-up of 7.8 years, there were 194 cases of incident dementia in the participants with complete data. Cox proportional hazard models for competing risks, stratified by sex, were defined to determine risk factors in relation to developing dementia.Results:The incidence rate of dementia increased from 5.57/1,000 person-years at 65–69 years of age to 30.06/1,000 person-years at 80–84 years. Cox proportional hazard models for competing risks of incidence of dementia and death revealed that, among men, significant risk factors were heart failure, Parkinson's disease, family history of dementia, mild depressive symptomatology and age, while triglycerides were associated with a lower risk of developing dementia. Significant risk factors in women were age, both mild and severe depressive symptomatology, glycemia ≥109 mg/dL, and a BMI < 24.1 kg/m2. Even as little as three years of schooling was found to be a significant protective factor against the incidence of dementia only for women.Conclusions:Our results suggest that there is an effect modification by gender in our study population in relation to the association between low education level, lipid profile, BMI, and glycemia and dementia.

Published
2013
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12. Frailty syndrome and the risk of vascular dementia: The Italian Longitudinal Study on Aging

Author

Solfrizzi V, Scafato E, Frisardi V, Seripa D, Logroscino G, Maggi S, Imbimbo BP, Galluzzo L, Baldereschi M, Gandin C, Di Carlo A, Inzitari D, Crepaldi G, Pilotto A, Panza F, Farchi G, Capurso A, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Amaducci L, Gandolfo C, Conti M, Franceschi M, Scarlato G, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Minicucci N, Noale M, Grigoletto F, Perissinotto E, Carbonin P., Solfrizzi, V, Scafato, E, Frisardi, V, Seripa, D, Logroscino, G, Maggi, S, Imbimbo, Bp, Galluzzo, L, Baldereschi, M, Gandin, C, Di Carlo, A, Inzitari, D, Crepaldi, G, Pilotto, A, Panza, F, Farchi, G, Capurso, A, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Amaducci, L, Gandolfo, C, Conti, M, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Minicucci, N, Noale, M, Grigoletto, F, Perissinotto, E, and Carbonin, P.

Subjects
Male, Gerontology, Aging, Longitudinal study, medicine.medical_specialty, Epidemiology, Alzheimer's disease, Cerebrovascular disease, Cognition, Dementia, Frailty, Vascular dementia, Aged, Aged, 80 and over, Dementia, Vascular, Female, Humans, Incidence, Italy, Syndrome, Frail Elderly, Frailty syndrome, Cellular and Molecular Neuroscience, Developmental Neuroscience, Vascular, 80 and over, medicine, Risk factor, Proportional hazards model, business.industry, Health Policy, Hazard ratio, medicine.disease, Confidence interval, Surgery, Psychiatry and Mental health, Neurology (clinical), Geriatrics and Gerontology, business
Abstract

Background Frailty is a clinical syndrome generally associated with a greater risk for adverse outcomes such as falls, disability, institutionalization, and death. Cognition and dementia have already been considered as components of frailty, but the role of frailty as a possible determinant of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) has been poorly investigated. We estimated the predictive role of frailty syndrome on incident dementia and its subtypes in a nondemented, Italian, older population. Methods We evaluated 2581 individuals recruited from the Italian Longitudinal Study on Aging sample population consisting of 5632 subjects aged 65 to 84 years and with a 3.9-year median follow-up. A phenotype of frailty according to a modified measurement of Cardiovascular Health Study criteria was operationalized. Dementia, AD, and VaD were classified using current published criteria. Results Over a 3.5-year follow-up, 65 of 2581 (2.5%) older subjects, 16 among 252 frail individuals (6.3%), of which 9 were affected by VaD (3.6%), developed overall dementia. In a proportional hazards model, frailty syndrome was associated with a significantly increased risk of overall dementia (adjusted hazard ratio: 1.85; 95% confidence interval: 1.01–3.40) and, in particular, VaD (adjusted hazard ratio: 2.68; 95% confidence interval: 1.16–7.17). The risk of AD or other types of dementia did not significantly change in frail individuals in comparison with subjects without frailty syndrome. Conclusion In our large population-based sample, frailty syndrome was a short-term predictor of overall dementia and VaD.

Published
2012
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13. Daily Function as Predictor of Dementia in Cognitive Impairment, No Dementia (CIND) and Mild Cognitive Impairment (MCI): An 8-Year Follow-Up in the ILSA Study

Author

Di Carlo, Antonio, Baldereschi, Marzia, Lamassa, Maria, Bovis, Francesca, Inzitari, Marco, Solfrizzi, Vincenzo, Panza, Francesco, Galluzzo, Lucia, Scafato, Emanuele, Inzitari, Domenico, Malara, Alba, Scafato, E., Farchi, G., Galluzzo, L., Gandin, C., Capurso, A., Panza, F., Solfrizzi, V., Lepore, V., Livrea, P., Motta, L., Carnazzo, G., Motta, M., Bentivegna, P., Bonaiuto, S., Cruciani, G., Fini, F., Vesprini, A., Postacchini, D., Inzitari, D., Amaducci, L., Di Carlo, A., Baldereschi, M., Ghetti, A., Vergassola, R., Gandolfo, C., Conti, M., Canal, N., Franceschi, M., Scarlato, G., Candelise, L., Scarpini, E., Rengo, F., Abete, P., Cacciatore, F., Covelluzzi, F., Enzi, G., Battistin, L., Sergi, G., Crepaldi, G., Bressan, M., Bortolan, G., Maggi, S., Minicuci, N., Noale, M., Grigoletto, F., Perissinotto, E., Carbonin, P., Di Carlo, Antonio, Baldereschi, Marzia, Lamassa, Maria, Bovis, Francesca, Inzitari, Marco, Solfrizzi, Vincenzo, Panza, Francesco, Galluzzo, Lucia, Scafato, E., Inzitari, Domenico, Malara, Alba, Farchi, G., Galluzzo, L., Gandin, C., Capurso, A., Panza, F., Solfrizzi, V., Lepore, V., Livrea, P., Motta, L., Carnazzo, G., Motta, M., Bentivegna, P., Bonaiuto, S., Cruciani, G., Fini, F., Vesprini, A., Postacchini, D., Inzitari, D., Amaducci, L., Di Carlo, A., Baldereschi, M., Ghetti, A., Vergassola, R., Gandolfo, C., Conti, M., Canal, N., Franceschi, M., Scarlato, G., Candelise, L., Scarpini, E., Rengo, F., Abete, P., Cacciatore, F., Covelluzzi, F., Enzi, G., Battistin, L., Sergi, G., Crepaldi, G., Bressan, M., Bortolan, G., Maggi, S., Minicuci, N., Noale, M., Grigoletto, F., Perissinotto, E., and Carbonin, P.

Subjects
Male, Gerontology, Longitudinal study, Time Factors, Activities of daily living, Psychological intervention, Neuropsychological Tests, Community Health Planning, Cohort Studies, 03 medical and health sciences, Motor performance, Longitudinal studie, 0302 clinical medicine, Predictive Value of Tests, Activities of Daily Living, mental disorders, 80 and over, medicine, Instrumental activities of daily living, Humans, Dementia, Cognitive Dysfunction, 030212 general & internal medicine, Mild cognitive impairment (MCI), Longitudinal studies, Mild cognitive impairment, Age Factors, Aged, Aged, 80 and over, Disease Progression, Female, Italy, Mental Status and Dementia Tests, Proportional Hazards Models, Cognitive impairment, Proportional hazards model, General Neuroscience, Incidence (epidemiology), General Medicine, medicine.disease, Clinical Psychology, Psychiatry and Mental Health, Geriatrics and Gerontology, Psychology, human activities, 030217 neurology & neurosurgery
Abstract

ACKGROUND: Preclinical cognitive changes may predict an increased risk of dementia, allowing selection of subgroups as possible targets for preventive or therapeutic interventions. OBJECTIVE: To evaluate the predictive effect of daily functioning and motor performance (MP) on the progression to dementia in normal cognition, cognitive impairment, no dementia (CIND), and mild cognitive impairment (MCI). METHODS: The Italian Longitudinal Study on Aging is a large population-based survey on age-related diseases of the cardiovascular and nervous systems. After the baseline assessment, to detect prevalent cases of cognitive impairment and dementia, participants were re-examined at 4-year and 8-year follow-ups. Functional independence was evaluated using the Index of Activities of Daily Living (ADL) and the Instrumental Activities of Daily Living (IADL) Scale. A six-test battery was used to assess MP. RESULTS: Overall, 2,386 individuals were included, for a total of 16,545 person-years. Eight-year incidence of dementia (per 1,000 person-years) was 12.69 in total sample, 9.86 in subjects with normal cognition at baseline, 22.99 in CIND, and 21.43 in MCI. Progression to dementia was significantly higher with increasing baseline ADL and IADL impairment, and with a worse MP. In Cox regression analyses controlled for demographics and major age-related conditions, increased IADL impairment was the stronger predictor of progression to dementia (p

Published
2016

14. Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging

Author

Solfrizzi V, Scafato E, Frisardi V, Seripa D, Logroscino G, Kehoe PG, Imbimbo BP, Baldereschi M, Crepaldi G, Di Carlo A, Galluzzo L, Gandin C, Inzitari D, Maggi S, Pilotto A, Panza F, Farchi G, Capurso A, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Amaducci L, Gandolfo C, Conti M, Canal N, Franceschi M, Scarlato G, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Minicucci N, Noale M, Grigoletto F, Perissinotto E., Solfrizzi, V, Scafato, E, Frisardi, V, Seripa, D, Logroscino, G, Kehoe, Pg, Imbimbo, Bp, Baldereschi, M, Crepaldi, G, Di Carlo, A, Galluzzo, L, Gandin, C, Inzitari, D, Maggi, S, Pilotto, A, Panza, F, Farchi, G, Capurso, A, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Amaducci, L, Gandolfo, C, Conti, M, Canal, N, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Minicucci, N, Noale, M, Grigoletto, F, and Perissinotto, E.

Subjects
Male, Aging, medicine.medical_specialty, Population, Angiotensin-Converting Enzyme Inhibitors, Statistics, Nonparametric, Article, Risk Factors, Internal medicine, Activities of Daily Living, 80 and over, medicine, Humans, Dementia, Nonparametric, Cognitive Dysfunction, Longitudinal Studies, Enalapril, education, Vascular dementia, Antihypertensive drugs, Aged, Proportional Hazards Models, Aged, 80 and over, education.field_of_study, Chi-Square Distribution, business.industry, Incidence, Statistics, Hazard ratio, Lisinopril, Mild cognitive impairment, Captopril, General Medicine, Angiotensin-converting enzyme inhibitors, Female, Hypertension, Italy, medicine.disease, Blood pressure, Endocrinology, Geriatrics and Gerontology, business, medicine.drug
Abstract

Midlife elevated blood pressure and hypertension contribute to the development of Alzheimer's disease (AD) and overall dementia. We sought to estimate whether angiotensin-converting enzyme inhibitors (ACE-Is) reduced the risk of developing mild cognitive impairment (MCI) in cognitively normal individuals. In the Italian Longitudinal Study on Aging, we evaluated 1,445 cognitively normal individuals treated for hypertension but without congestive heart failure from a population-based sample from eight Italian municipalities with a 3.5-year follow-up. MCI was diagnosed with current clinical criteria. Dementia, AD, and vascular dementia were diagnosed based on DSM-IIIR criteria, NINCDS–ADRDA criteria, and ICD-10 codes. Among 873 hypertension-treated cognitively normal subjects, there was no significant association between continuous exposure to all ACE-Is and risk of incident MCI compared with other antihypertensive drugs [hazard ratio (HR), 0.45, 95% confidence interval (CI), 0.16–1.28]. Captopril exposure alone did not significantly modify the risk of incident MCI (HR, 1.80, 95% CI, 0.39–8.37). However, the enalapril sub-group alone (HR, 0.17, 95% CI, 0.04 –0.84) or combined with the lisinopril sub-group (HR, 0.27, 95% CI, 0.08–0.96), another ACE-I structurally related to enalapril and with similar potency, were associated with a reduced risk of incident MCI. Study duration exposure to ACE-Is as a “class” was not associated with incident MCI in older hypertensive adults. However, within-class differences linked to different chemical structures and/or drug potencies may exist, with a possible effect of the enalapril and lisinopril sub-groups in reducing the risk of incident MCI.

Published
2011
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15. Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging.

Author

Solfrizzi, Vincenzo, Scafato, Emanuele, Lozupone, Madia, Seripa, Davide, Giannini, Michele, Sardone, Rodolfo, Bonfiglio, Caterina, Abbrescia, Daniela I., Galluzzo, Lucia, Gandin, Claudia, Baldereschi, Marzia, Di Carlo, Antonio, Inzitari, Domenico, Daniele, Antonio, Sabbã , Carlo, Logroscino, Giancarlo, Panza, Francesco, Scafato, E., Farchi, G., Galluzzo, L., Gandin, C., Capurso, A., Panza, F., Solfrizzi, V., Lepore, V., Livrea, P., Motta, Ljanka, Carnazzo, G., Motta, M., Bentivegna, P., Bonaiuto, S., Cruciani, G., Postacchini, D., Inzitari, D., Amaducci, L., Di Carlo, A., Baldereschi, M., Gandolfo, C., Conti, M., Canal, N., Franceschi, M., Scarlato, G., Candelise, L., Scapini, E., Rengo, F., Abete, P., Cacciatore, F., Enzi, G., Battistin, L., Sergi, G., Crepaldi, G., Maggi, S., Minicucci, N., Noale, M., Grigoletto, F., Perissinotto, E., Carbonin, P., Daniele, Antonio (ORCID:0000-0003-1641-5852), Solfrizzi, Vincenzo, Scafato, Emanuele, Lozupone, Madia, Seripa, Davide, Giannini, Michele, Sardone, Rodolfo, Bonfiglio, Caterina, Abbrescia, Daniela I., Galluzzo, Lucia, Gandin, Claudia, Baldereschi, Marzia, Di Carlo, Antonio, Inzitari, Domenico, Daniele, Antonio, Sabbã , Carlo, Logroscino, Giancarlo, Panza, Francesco, Scafato, E., Farchi, G., Galluzzo, L., Gandin, C., Capurso, A., Panza, F., Solfrizzi, V., Lepore, V., Livrea, P., Motta, Ljanka, Carnazzo, G., Motta, M., Bentivegna, P., Bonaiuto, S., Cruciani, G., Postacchini, D., Inzitari, D., Amaducci, L., Di Carlo, A., Baldereschi, M., Gandolfo, C., Conti, M., Canal, N., Franceschi, M., Scarlato, G., Candelise, L., Scapini, E., Rengo, F., Abete, P., Cacciatore, F., Enzi, G., Battistin, L., Sergi, G., Crepaldi, G., Maggi, S., Minicucci, N., Noale, M., Grigoletto, F., Perissinotto, E., Carbonin, P., and Daniele, Antonio (ORCID:0000-0003-1641-5852)

Abstract

Objective Cognitive frailty is a condition recently defined by operationalized criteria describing the simultaneous presence of physical frailty and mild cognitive impairment (MCI). Two subtypes for this clinical construct have been proposed: “potentially reversible” cognitive frailty (physical frailty plus MCI) and “reversible” cognitive frailty (physical frailty plus pre-MCI subjective cognitive decline). Here the prevalence of a potentially reversible cognitive frailty model was estimated. It was also evaluated if introducing a diagnosis of MCI in older subjects with physical frailty could have an additive role on the risk of dementia, disability, and all-cause mortality in comparison with frailty state or MCI condition alone, with analyses separately performed for inflammatory state. Methods In 2,373 individuals from the population-based Italian Longitudinal Study on Aging with a 3.5-year-follow-up, we operationally categorized older individuals without dementia into four groups: non-frail/non-MCI, non-frail/MCI, frail/non-MCI, and frail/MCI. Results The prevalence of potentially reversible cognitive frailty was 1%, increasing with age and more represented in women than in men, and all groups were associated with significant increased incident rate ratios of dementia, disability, and mortality. A significant difference in rates of disability has been found between the MCI and non-MCI groups (contrasts of adjusted predictions: 0.461; 95% confidence interval: 0.187–0.735) in frail individuals with high inflammatory states (fibrinogen >339 mg/dL). Conclusion In older individuals without dementia and with elevated inflammation, a potentially reversible cognitive frailty model could have a significant additional predictive effect on the risk of disability than the single conditions of frailty or MCI.

Published
2017

19. Hippocampal atrophy in people with memory deficits: results from the population-based IPREA study

Author

Ferrarini L, van Lew B, Reiber JH, Gandin C, Galluzzo L, Scafato E, FrisoniGB, Milles J, Pievani M, IPREA Working Group: Scafato E, Farchi G, Giampaoli S, Mariotti S, Ghirini S, Martire S, Di Pasquale L, Maggi S, Crepaldi G, Enzi G, Gallina P, Inzitari D, Baldereschi M, Di Carlo A, Frisoni GB, Galluzzi S, Gandolfo C, Conti M, Postacchini D, Cruciani G, Giuli C, Capurso A, Solfrizzi V, Panza F, Rengo F, ABETE, PASQUALE, Motta M, Negrini R, Forti P, Tabanelli P, Cocchi A, Zuccal G, Cacciatore F, Calabrese C, Sica G, Estraneo A, Foundation SM, Consoli D, Naso F, Torcasio G, Valentia V, Mecocci P, Rinaldi P, Serafini V, Senin U., Ferrarini, L, van Lew, B, Reiber, Jh, Gandin, C, Galluzzo, L, Scafato, E, Frisonigb, Milles, J, Pievani, M, IPREA Working Group: Scafato, E, Farchi, G, Giampaoli, S, Mariotti, S, Ghirini, S, Martire, S, Di Pasquale, L, Maggi, S, Crepaldi, G, Enzi, G, Gallina, P, Inzitari, D, Baldereschi, M, Di Carlo, A, Frisoni, Gb, Galluzzi, S, Gandolfo, C, Conti, M, Postacchini, D, Cruciani, G, Giuli, C, Capurso, A, Solfrizzi, V, Panza, F, Rengo, F, Abete, Pasquale, Motta, M, Negrini, R, Forti, P, Tabanelli, P, Cocchi, A, Zuccal, G, Cacciatore, F, Calabrese, C, Sica, G, Estraneo, A, Foundation, Sm, Consoli, D, Naso, F, Torcasio, G, Valentia, V, Mecocci, P, Rinaldi, P, Serafini, V, and Senin, U.

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Population, Not Otherwise Specified, Hippocampus, Audiology, Hippocampal formation, medicine.disease, population-based, memory, Psychiatry and Mental health, Clinical Psychology, Atrophy, hippocampal atrophy, medicine, Dementia, Memory impairment, Geriatrics and Gerontology, Alzheimer's disease, business, education, Gerontology, MRI
Abstract

Background:Clinical studies have shown that hippocampal atrophy is present before dementia in people with memory deficits and can predict dementia development. The question remains whether this association holds in the general population. This is of interest for the possible use of hippocampal atrophy to screen population for preventive interventions. The aim of this study was to assess hippocampal volume and shape abnormalities in elderly adults with memory deficits in a cross-sectional population-based study.Methods:We included individuals participating in the Italian Project on the Epidemiology of Alzheimer Disease (IPREA) study: 75 cognitively normal individuals (HC), 31 individuals with memory deficits (MEM), and 31 individuals with memory deficits not otherwise specified (MEMnos). Hippocampal volumes and shape were extracted through manual tracing and the growing and adaptive meshes (GAMEs) shape-modeling algorithm. We investigated between-group differences in hippocampal volume and shape, and correlations with memory deficits.Results:In MEM participants, hippocampal volumes were significantly smaller than in HC and were mildly associated with worse memory scores. Memory-associated shape changes mapped to the anterior hippocampus. Shape-based analysis detected no significant difference between MEM and HC, while MEMnos showed shape changes in the posterior hippocampus compared with HC and MEM groups.Conclusions:These findings support the discriminant validity of hippocampal volumetry as a biomarker of memory impairment in the general population. The detection of shape changes in MEMnos but not in MEM participants suggests that shape-based biomarkers might lack sensitivity to detect Alzheimer's-like pathology in the general population.

Published
2014

20. Prevalence of diabetes and depressive symptomatology and their effect on mortality risk in elderly Italians: The Italian Longitudinal Study on Aging

Author

Limongi F, Noale M, Crepaldi G, Maggi S, ILSA Working Group: Scafato E, Farchi G, Galluzzo L, Gandin C, Capurso A, Panza F, Solfrizzi V, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Inzitari D, Amaducci L, Di Carlo A, Baldereschi M, Gandolfo C, Conti M, Canal N, Franceschi M, Scarlato G, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Minicuci N, Grigoletto F, Perissinotto E, Carbonin P., Limongi, F, Noale, M, Crepaldi, G, Maggi, S, ILSA Working Group: Scafato, E, Farchi, G, Galluzzo, L, Gandin, C, Capurso, A, Panza, F, Solfrizzi, V, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Inzitari, D, Amaducci, L, Di Carlo, A, Baldereschi, M, Gandolfo, C, Conti, M, Canal, N, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Minicuci, N, Grigoletto, F, Perissinotto, E, and Carbonin, P.

Published
2014

21. Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging

Author

Solfrizzi, Vincenzo, primary, Scafato, Emanuele, additional, Lozupone, Madia, additional, Seripa, Davide, additional, Giannini, Michele, additional, Sardone, Rodolfo, additional, Bonfiglio, Caterina, additional, Abbrescia, Daniela I., additional, Galluzzo, Lucia, additional, Gandin, Claudia, additional, Baldereschi, Marzia, additional, Di Carlo, Antonio, additional, Inzitari, Domenico, additional, Daniele, Antonio, additional, Sabbà, Carlo, additional, Logroscino, Giancarlo, additional, Panza, Francesco, additional, Scafato, E., additional, Farchi, G., additional, Galluzzo, L., additional, Gandin, C., additional, Capurso, A., additional, Panza, F., additional, Solfrizzi, V., additional, Lepore, V., additional, Livrea, P., additional, Motta, L., additional, Carnazzo, G., additional, Motta, M., additional, Bentivegna, P., additional, Bonaiuto, S., additional, Cruciani, G., additional, Postacchini, D., additional, Inzitari, D., additional, Amaducci, L., additional, Di Carlo, A., additional, Baldereschi, M., additional, Gandolfo, C., additional, Conti, M., additional, Canal, N., additional, Franceschi, M., additional, Scarlato, G., additional, Candelise, L., additional, Scapini, E., additional, Rengo, F., additional, Abete, P., additional, Cacciatore, F., additional, Enzi, G., additional, Battistin, L., additional, Sergi, G., additional, Crepaldi, G., additional, Maggi, S., additional, Minicucci, N., additional, Noale, M., additional, Grigoletto, F., additional, Perissinotto, E., additional, and Carbonin, P., additional

Published
2017
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22. Vascular factors predict polyneuropathy in a non-diabetic elderly population

Author

Baldereschi M, Inzitari M, Di Carlo A, Bovis F, Maggi S, Capurso A, Solfrizzi V, Panza F, Scafato E, Inzitari D, Amaducci L, Farchi G, Galluzzo L, Gandin C, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Gandolfo C, Conti M, Franceschi M, Scarlato G, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Crepaldi G, Minicucci N, Noale M, Grigoletto F, Perissinotto E, Carbonin P., Baldereschi, M, Inzitari, M, Di Carlo, A, Bovis, F, Maggi, S, Capurso, A, Solfrizzi, V, Panza, F, Scafato, E, Inzitari, D, Amaducci, L, Farchi, G, Galluzzo, L, Gandin, C, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Gandolfo, C, Conti, M, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Crepaldi, G, Minicucci, N, Noale, M, Grigoletto, F, Perissinotto, E, and Carbonin, P.

Subjects
Male, medicine.medical_specialty, Aging, Community-Based Participatory Research, Epidemiology, Dermatology, Comorbidity, Cohort Studies, Polyneuropathies, Predictive Value of Tests, Risk Factors, Internal medicine, Diabetes mellitus, Polyneuropathy, medicine, 80 and over, Diabetes Mellitus, Humans, Vascular Diseases, Aged, Proportional Hazards Models, Peripheral neuropathies, Aged, 80 and over, Univariate analysis, Proportional hazards model, business.industry, Incidence (epidemiology), Medicine (all), Incidence, General Medicine, medicine.disease, Surgery, Italy, Psychiatry and Mental Health, Relative risk, Multivariate Analysis, Female, Neurology (clinical), business, Non-diabetic polyneuropathy, 2708, Cohort study
Abstract

We prospectively examined whether vascularfactors are related to an increased incidence of ChronicIdiopathic Distal Symmetric Neuropathy (CI-DSN) in anon-diabetic elderly population. In 8 Italian municipalities,2,512 men and women without both diabetes and CI-DSNat baseline are examined. Potential effect of vascular fac-tors was estimated by regressing new onset CI-DSN on theoccurrence of several vascular diseases and risk factors.Multivariate relative risks of CI-DSN were estimated byCox proportional hazards models. After 3.8 (±2.4) years offollow-up, we documented 51 incident CI-DSN cases. Atunivariate analysis, age, comorbidity, waist circumference,leg length, peripheral artery disease, and coronary heartdisease proved to increase the risk of developing CI-DSN.By multivariate analyses, only age (RR=1.08; 95 % CI,1.02–1.14), leg length (RR=1.05; 95 % CI, 1.01–1.1) andperipheral artery disease (RR=2.75; 95 % CI, 1.15–6.56)proved significant predictors of CI-DSN. Separate analysesby gender show that age is an independent predictor of CI-DSN both in men and in women, while PAD predicts thedisease only in men, together with body height. Incidenceof CI-DSN is higher in individuals carrying vascular con-ditions. In men, the presence at baseline of peripheralartery disease is associated with a threefold increase in therisk of developing CI-DSN. The incidence of neuropathy innon-diabetic individuals is associated with potentiallymodifiable vascular factors.

Published
2012

23. An index to measure the association between dietary patterns and coronary heart disease risk factors: findings from two Italian studies

Author

Massari, M., Freeman, K. M., Seccareccia, F., Menotti, A., Farchi, G., Research Group of the RIFLE Project, and De Santis, A.

Subjects
Adult, Blood Glucose, Male, Coronary disease, Cross-sectional studies, Food habits, Italy, Risk factors, medicine.medical_specialty, Index (economics), Alcohol Drinking, Epidemiology, Cross-sectional study, Blood Pressure, Coronary Disease, Body Mass Index, Risk Factors, Environmental health, Internal medicine, Linear regression, medicine, Humans, Rifle, Exercise, business.industry, Smoking, Confounding, Public Health, Environmental and Occupational Health, Feeding Behavior, Middle Aged, Cholesterol, Blood pressure, Endocrinology, Multivariate Analysis, Linear Models, Life expectancy, Female, business, Body mass index
Abstract

To examine the association between established coronary heart disease (CHD) risk factors and eating patterns by creating a dietary index utilizing a limited amount of food frequency questionnaire data on specified indicator foods.Selected data from the Italian Risk Factors and Life Expectancy (RIFLE) project collected between 1978-1979 and 1983-1984 on 7665 men and women, aged 20-59 years, were used to compute a dietary index summarizing the relative proportion of fatty to non-fatty foods. The association between this index and systolic and diastolic blood pressure (SBP, DBP), body mass index, total serum cholesterol (TC), and blood glucose, controlling for potential confounders was then tested using multiple linear regression.Among men, a positive association was found between the index and all five CHD risk factors (P0.01). Among women, the associations were weaker, becoming statistically significant only for TC and glucose.Our food index was able to detect relationships between diet and traditional CHD risk factors. A tool such as this, which requires only a limited number of key indicator food items, might enhance the use of existing food frequency questionnaires and also streamline the process of collecting new dietary information.

Published
2004
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24. Alcohol consumption and metabolic syndrome in the elderly: results from the Italian longitudinal study on aging

Author

Buja, A, Scafato, E, Sergi, G, Maggi, S, Suhad, Ma, Rausa, G, Coin, A, Baldi, I, Manzato, E, Galluzzo, L, Enzi, G, Perissinotto, E, Crepaldi, G, Minicuci, N, Noale, M, Grigoletto, F, Enzi, Battistin, L, Inzitari, D, DI CARLO, A, Baldereschi, M, Farchi, G, Gandin, C, Capurso, A, Panza, F, Solfrizzi, V, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Gandolfo, Carlo, Conti, M, Canal, N, Franceschi, M, Candelise, L, Scapini, E, Rengo, F, Abete, P, Cacciatore, F, Carbonin, Gp, Buja, A, Scafato, E, Sergi, G, Maggi, S, Suhad, Ma, Rausa, G, Coin, A, Baldi, I, Manzato, E, Galluzzo, L, Enzi, G, Perissinotto, E, ILSA Working Group: Crepaldi, G, Minicuci, N, Noale, M, Grigoletto, F, Enzi, Battistin, L, Inzitari, D, Di Carlo, A, Baldereschi, M, Farchi, G, Gandin, C, Capurso, A, Panza, F, Solfrizzi, V, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Gandolfo, C, Conti, M, Canal, N, Franceschi, M, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, and Carbonin, G. P.

Abstract

Background/Objectives: Although there is plenty of evidence of the association between metabolic syndrome (MS) and cardiovascular disease, the relationship between alcohol consumption and MS is still questioned. The few publications with respect to the elderly seem to indicate that alcohol consumption is unassociated with MS. The aim of this study was to assess the association between alcohol consumption and the prevalence and incidence of MS, as well as its components in a large sample of Italian elderly people. Subjects/Methods: This is a multicenter study on a population-based sample of Italian people aged 65–84 years. The Italian Longitudinal Study on Aging (ILSA) included a prevalence phase in 1992 and an incidence phase from 1995 to 1996. The median length of follow-up was 3.5 years. In the present study, the analysis included 1321 men grouped into five alcohol consumption classes: abstainers, and those consuming p12, 13–24, 25–47 or X48 g of alcohol in a day. Among the 1122 women considered, the last two of the above five categories were pooled together (424 g/day). MS was defined according to ATP III criteria. All statistical analyses were stratified by gender. Results: Adjusted odds ratios showed that categorized alcohol consumption was not significantly associated with the prevalence and incidence of MS when compared with abstainers in either gender. For the MS incidence survey, three of five components (systolic pressure, glycemia and waist circumference) proved to be significantly and harmfully affected by alcohol consumption in males, whereas no such significant association emerged in females. Conclusions: These results suggest that alcohol can modify an individual’s metabolic condition and that, even among the elderly, men might be more sensitive to the effects of alcohol than women.

Published
2010

25. Prevalence of aging-associated cognitive decline in an Italian elderly population: Results from cross-sectional phase of Italian Project on Epidemiology of Alzheimer's disease (IPREA)

Author

Scafato E, Gandin C, Galluzzo L, Ghirini S, Cacciatore F, Capurso A, Solfrizzi V, Panza F, Cocchi A, Consoli D, Enzi G, Frisoni G, B, Gandolfo C, Giampaoli S, Inzitari D, Maggi S, Crepaldi G, Mariotti S, Mecocci P, Motta M, Negrini R, Postacchini D, Rengo F, Farchi G, Martire S, Gallina P, Baldereschi M, Di Carlo A, Conti M, Galluzzi S, Cruciani G, Giuli C, ABETE, PASQUALE, Forti P, Tabanelli P, Zuccalà G, Calabrese C, Sica G, Estraneo A, Naso F, Torcasio G, Rinaldi P, Serafini V, Senin U., Scafato, E, Gandin, C, Galluzzo, L, Ghirini, S, Cacciatore, F, Capurso, A, Solfrizzi, V, Panza, F, Cocchi, A, Consoli, D, Enzi, G, Frisoni, G, B, Gandolfo, C, Giampaoli, S, Inzitari, D, Maggi, S, Crepaldi, G, Mariotti, S, Mecocci, P, Motta, M, Negrini, R, Postacchini, D, Rengo, F, Farchi, G, Martire, S, Gallina, P, Baldereschi, M, Di Carlo, A, Conti, M, Galluzzi, S, Cruciani, G, Giuli, C, Abete, Pasquale, Forti, P, Tabanelli, P, Zuccalà, G, Calabrese, C, Sica, G, Estraneo, A, Naso, F, Torcasio, G, Rinaldi, P, Serafini, V, and Senin, U.

Abstract

Background and aims: The prevalence of the preclinical phase of dementia varies greatly, according to the diagnostic criteria and assessment procedures applied. The purpose of this study was to estimate the prevalence of cognitive impairment according to the Aging-Associated Cognitive Decline (AACD) diagnostic criteria in an Italian elderly population. Methods: In a multicenter community-based prospective study, 4785 Italian subjects aged 65-84 years, randomly selected from the registries of 12 Italian municipalities, were assessed by personal and informant interviews, physical and neurological examinations and an extensive neuropsychological battery. Results: Of these older subjects, 274 (9.2%) fulfilled all the AACD criteria, whereas 561 (18.8%) fulfilled only 3 of them (AACD-3). When the two groups diagnosed according to AACD criteria (AACD and AACD- 3) were merged, the prevalence was 28.0% (28.3% for men, 27.6% for women). Two other groups of subjects were also identified: a) Subjects with Objective evidence of Cognitive Decline without cognitive complaints (OCD), 508 (17.0%), i.e., subjects with documented neuropsychological deficits, although neither subjects nor informants reported cognitive complaints; and b) Subjects with Cognitive Complaints without objective demonstrable cognitive deficits (CC), 44 (1.5%), i.e., subjects and/or informants reported cognitive complaints without evidence of neuropsychological deficits. Thus, taking into account the additional OCD group, a total of 1343 persons with cognitive impairment without dementia (45.0%) was identified. Conclusions: On the basis of our results, we estimate that 45% of our population-based Italian sample aged 65-84 years had some kind of cognitive deficits without dementia.

Published
2010

26. Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing

Author

Solfrizzi, V, Scafato, E, Capurso, C, D'Introno, A, Colacicco, Am, Frisardi, V, Vendemiale, G, Baldereschi, M, Crepaldi, G, DI CARLO, A, Galluzzo, L, Gandin, C, Inzitari, D, Maggi, S, Capurso, A, Panza, F, Farchi, G, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Amaducci, L, Gandolfo, Carlo, Conti, M, Canal, N, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, P, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Minicucci, N, Noale, M, Grigoletto, F, Perissinotto, E, Carbonin, P., Solfrizzi, V, Scafato, E, Capurso, C, D'Introno, A, Colacicco, Am, Frisardi, V, Vendemiale, G, Baldereschi, M, Crepaldi, G, Di Carlo, A, Galluzzo, L, Gandin, C, Inzitari, D, Maggi, S, Capurso, A, Panza, F, Italian Longitudinal Study on Ageing Working Group: Farchi, G, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Amaducci, L, Gandolfo, C, Conti, M, Canal, N, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Minicucci, N, Noale, M, Grigoletto, F, Perissinotto, E, and Carbonin, P.

Abstract

Objective The authors investigated the relationship of metabolic syndrome (MetS) and its individual components with incident dementia in a prospective population-based study with a 3.5-year follow-up. Methods A total of 2097 participants from a sample of 5632 subjects (65e84 years old) from the Italian Longitudinal Study on Ageing were evaluated. MetS was defined according to the Third Adults Treatment Panel of the National Cholesterol Education Program criteria. Dementia, Alzheimer disease (AD) and vascular dementia (VaD) were classified using current published criteria. Results MetS subjects (N¼918) compared with those without MetS (N¼1179) had an increased risk for VaD (1.63% vs 0.85%, adjusted hazard ratio (HR) 3.71, 95% CI 1.40 to 9.83). After excluding 338 subjects with baseline undernutrition, MetS subjects compared with those without MetS had an elevated risk of VaD (adjusted HR, 3.82; 95% CI 1.32 to 11.06). Moreover, those with MetS and high inflammation had a still further higher risk of VaD (multivariate adjusted HR, 9.55; 95% CI 1.17 to 78.17) compared with those without MetS and high inflammation. On the other hand, those with MetS and low inflammation compared with those without MetS and low inflammation did not exhibit a significant increased risk of VaD (adjusted HR, 3.31, 95% CI 0.91 to 12.14). Finally, a synergistic MetS effect versus its individual component effects was verified on the risk of VaD. Conclusion In our population, MetS subjects had an elevated risk of VaD that increased after excluding patients with baseline undernutrition and selecting MetS subjects with high inflammation.

Published
2010

27. Alcohol consumption and cardiovascular risk factors in older lifelong wine drinkers: the Italian Longitudinal Study on Aging

Author

Perissinotto E, Buja A, Maggi S, Enzi G, Manzato E, Scafato E, Mastrangelo G, Frigo AC, Coin A, Crepaldi G, Sergi G, Farchi G, Galluzzo L, Gandin C, Di Carlo A, Baldereschi M, Minicucci N, Noale M, Capurso A, Panza F, Solfrizzi V, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Inzitari D, Amaducci L, Gandolfo C, Conti M, Canal N, Franceschi M, Scarlato G, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Battistin L, Grigoletto F, Carbonin P., Perissinotto, E, Buja, A, Maggi, S, Enzi, G, Manzato, E, Scafato, E, Mastrangelo, G, Frigo, Ac, Coin, A, Crepaldi, G, Sergi, G, Farchi, G, Galluzzo, L, Gandin, C, Di Carlo, A, Baldereschi, M, Minicucci, N, Noale, M, Capurso, A, Panza, F, Solfrizzi, V, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Inzitari, D, Amaducci, L, Gandolfo, C, Conti, M, Canal, N, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Battistin, L, Grigoletto, F, and Carbonin, P.

Abstract

Background and aims: A protective effect of moderate alcohol consumption on the cardiovascular system has consistently been reported, but limited evidence has been produced on the association of alcohol with metabolic factors in the elderly. The aim of this study was to investigate the association between different levels of current alcohol consumption and cardiovascular risk factors in a representative sample of elderly Italian men, mainly wine drinkers. Methods and results: This is a cross-sectional multi-centre study on a population-based sample of Italian men aged 65e84 years, drawn from the Italian Longitudinal Study on Aging (ILSA) cohort. The analyses included 1896 men. Almost all the drinkers (98%) drank wine as a lifelong habit. Adjusted ORs for risk levels for cardiovascular factors (BMI, waist circumference, fibrinogen, a2 protein, white blood cells, HDL cholesterol, Apo A-I, total cholesterol, Apo B-I, triglycerides, LDL, glycated hemoglobin, insulin, fasting plasma glucose, HOMA IR, systolic and diastolic blood pressure) were estimated, comparing drinkers with teetotalers using multivariate logistic regression models. We found alcohol consumption in older age associated with healthier hematological values of fibrinogen, HDL cholesterol, Apo A-I lipoprotein and insulin, but it was also associated with a worse hematological picture of total, LDL cholesterol levels, and systolic pressure. Conclusion: Our results indicated in elderly moderate wine drinkers a noticeably safe metabolic, inflammatory and glycemic profile that might balance higher blood pressure, leading to a net benefit. These findings however need to be placed in relation to the known adverse social and health effects of heavy drinking.

Published
2010

28. Diabetes as a risk factor for cognitive decline in older patients

Author

Maggi S, Limongi F, Noale M, Romanato G, Tonin P, Rozzini R, Scafato E, Crepaldi G, ILSA Study Group, Minicuci N, Grigoletto F, Perissinotto E, Inzitari D, Di Carlo A, Baldereschi M, Farchi G, Galluzzo L, Gandin C, Capurso A, Panza F, Solfrizzi V, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Gandolfo C, Canal N, Franceschi M, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Carbonin P., Maggi, S, Limongi, F, Noale, M, Romanato, G, Tonin, P, Rozzini, R, Scafato, E, Crepaldi, G, ILSA Study, Group, Minicuci, N, Grigoletto, F, Perissinotto, E, Inzitari, D, Di Carlo, A, Baldereschi, M, Farchi, G, Galluzzo, L, Gandin, C, Capurso, A, Panza, F, Solfrizzi, V, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Gandolfo, C, Canal, N, Franceschi, M, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, and Carbonin, P.

Abstract

Aims: To assess the role of type 2 diabetes as a risk factor for cognitive decline among elderly people. Methods: Analyses were carried out on data from the Italian Longitudinal Study on Aging, a study on 5,632 subjects aged 65–84 years, with baseline in 1992 and follow-ups in 1996 and 2000. Results: At baseline, diabetic women had significantly worse scores on all cognitive tests compared to nondiabetic women, but did not show worsening over time, whereas men with diabetes did not show worse scores on cognitive tests at baseline compared to nondiabetic males; however, diabetes in men was associated with a risk of cognitive decline over time, particularly in attention. Higher levels of HbA 1c were associated with poorer performance on memory tests at follow-up in both sexes. Conclusion: The impact of diabetes on cognitive status might differ in older men and women, probably because of a survival effect, with a higher mortality at a younger age among diabetic men. The metabolic and cardiovascular abnormalities associated with diabetes might be responsible for the cognitive decline, at different rates and ages, in men and women. The routine assessment of diabetes complications in the elderly should include cognitive evaluation in both sexes.

Published
2009

29. Physical disability and depressive symptomatology in an elderly population: a complex relationship. The Italian Longitudinal Study on Aging (ILSA)

Author

Dalle Carbonare L, Maggi S, Noale M, Giannini S, Rozzini R, Lo Cascio V, Crepaldi G, ILSA Working Group, Minicuci N, Grigoletto F, Perissinotto E, Inzitari D, Di Carlo A, Baldereschi M, Scafato E, Farchi G, Galluzzo L, Gandin C, Capurso A, Panza F, Solfrizzi V, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Gandolfo C, Conti M, Canal N, Franceschi M, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Carbonin P., Dalle Carbonare, L, Maggi, S, Noale, M, Giannini, S, Rozzini, R, Lo Cascio, V, Crepaldi, G, ILSA Working, Group, Minicuci, N, Grigoletto, F, Perissinotto, E, Inzitari, D, Di Carlo, A, Baldereschi, M, Scafato, E, Farchi, G, Galluzzo, L, Gandin, C, Capurso, A, Panza, F, Solfrizzi, V, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Gandolfo, C, Conti, M, Canal, N, Franceschi, M, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, and Carbonin, P.

Abstract

Objectives: Depressive symptoms (DS) are very frequent in elderly individuals and are associated with negative outcomes. This study was undertaken to evaluate whether DS predict physical disability in this population. Methods: A prospective, community-based cohort study, this work included 5,632 individuals aged 65–84 years, who were recruited from the demographic registries of eight Italian municipalities in 1992. The complete data of 3,256 subjects were collected and analyzed. DS were assessed using the Geriatric Depression Scale with a score 10/30 indicating DS. All traditional risk factors for disability established by questionnaires and physical examinations were assessed at baseline. The outcomes were self-reported disability on the activities of daily living (ADL) test and the performance-based physical function assessment (Physical Performance Tests, PPT). The contribution of the predictive variables to the outcomes evaluated after a mean follow-up of 3.5 0.4 years was assessed using hierarchical logistic nested models. Results: Baseline DS was associated with higher rates of ADL disability (odds ratio [OR] 1.73, 95% confidence interval [CI] 1.12–2.66) and PPT disability (OR 1.83, 95% CI 1.17–2.85) in men and with ADL disability (OR 1.81, 95% CI 1.28 –2.55) in women. The independent predictors of PPT disability in women were arthritis (OR 2.13, 95% CI 1.28 –3.53) and age (OR 1.09; 95% CI 1.03–1.15). Conclusions: This study provides evidence that older persons who report DS are at higher risk of subsequent physical decline. In women, arthritis is a more powerful predictor of preclinical disability, as measured by PPT.

Published
2009

30. Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging

Author

Panza F, D'Introno A, Colacicco AM, Capurso C, Del Parigi A, Caselli RJ, Todarello O, Pellicani V, Santamato A, Scapicchio P, Maggi S, Scafato E, Gandin C, Capurso A, Solfrizzi V, Italian Longitudinal Study on Aging Working Group, Farchi G, Galluzzo L, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Inzitari D, Amaducci L, Di Carlo A, Baldereschi M, Gandolfo C, Conti M, Canal N, Franceschi M, Scarlato G, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Crepaldi G, Minicucci N, Noale M, Grigoletto F, Perissinotto E, Carbonin P., Panza, F, D'Introno, A, Colacicco, Am, Capurso, C, Del Parigi, A, Caselli, Rj, Todarello, O, Pellicani, V, Santamato, A, Scapicchio, P, Maggi, S, Scafato, E, Gandin, C, Capurso, A, Solfrizzi, V, Italian Longitudinal Study on Aging Working, Group, Farchi, G, Galluzzo, L, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Inzitari, D, Amaducci, L, Di Carlo, A, Baldereschi, M, Gandolfo, C, Conti, M, Canal, N, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Crepaldi, G, Minicucci, N, Noale, M, Grigoletto, F, Perissinotto, E, and Carbonin, P.

Abstract

Aims: We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. Methods: A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85–1.84, 2 = 1.30, p ! 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI. Conclusion: In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI.

Published
2008

31. Prevalence of Aging-Associated Cognitive Decline - AACD in an Italian elderly population: results from the cross sectional phase of the Italian PRoject on the Epidemiology of Alzheimer's disease (I.PR.E.A.)

Author

Scafato, E, Gandin, C, Galluzzo, L, Ghirini, S, Cacciatore, F, Capurso, A, Solfrizzi, V, Panza, F, Cocchi, A, Consoli, D, Enzi, G, Frisoni, Gb, Gandolfo, Carlo, Giampaoli, S, Inzitari, D, Maggi, S, Crepaldi, G, Mariotti, S, Mecocci, P, Motta, M, Negrini, R, Postacchini, D, Rengo, F, and Farchi, G.

Published
2010

32. Physical disability and depressive symptomatology in an elderly population: a complex relationship. The Italian Longitudinal Study on Aging (ILSA)

Author

DALLE CARBONARE LD, Maggi, S, Noale, M, Giannini, S, Rozzini, R, LO CASCIO, V, Crepaldi, G, AND ILSA WORKING GROUP CREPALDI, G, Minicuci, N, Grigoletto, F, Perissinotto, E, Inzitari, D, DI CARLO, A, Baldereschi, M, Scafato, E, Farchi, G, Galluzzo, L, Gandin, C, Capurso, A, Panza, F, Solfrizzi, V, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Gandolfo, Carlo, Conti, M, Canal, N, Franceschi, M, Candelise, L, Scapini, E, Rengo, F, Abete, P, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, and Carbonin, P.

Published
2009

33. Role of body mass index in the prediction of all cause mortality in over 62000 men and women. The Italian RIFLE Pooling Project

Author

SECCARECCIA F, LANTI M, MENOTTI A, SCANGA M, THE RIFLE RESEARCH GROUP, FARCHI G, CONTI S, MARENCO G, FALCHERO M, FERRARIO M, CESANA GC, TENCONI MT, MUSSI A, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G., DEVOTI, Gabriele, Seccareccia, F, Lanti, M, Menotti, A, Scanga, M, THE RIFLE RESEARCH, Group, Farchi, G, Conti, S, Marenco, G, Falchero, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Mussi, A, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G.

Published
1998

34. Electrocardiographic Minnesota Code findings predicting short-term mortality in asymptomatic subjects. The Italian RIFLE Pooling Project (Risk Factors and Life Expectancy)

Author

MENOTTI A, SECCARECCIA F, THE RIFLE RESEARCH GROUP, LANTI M, FARCHI G, CONTI S, DIMA F, SCANGA M, MARENCO G, FALCHERO M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDATO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Menotti, A, Seccareccia, F, THE RIFLE RESEARCH, Group, Lanti, M, Farchi, G, Conti, S, Dima, F, Scanga, M, Marenco, G, Falchero, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addato, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1997

35. Syndrome X: prevalence in a large population-based study

Author

LIU J, TREVISAN M, MENOTTI A, THE RIFLE RESEARCH GROUP, LANTI M, FARCHI G, CONTI S, SECCARECCIA F, DIMA F, SCANGA M, MARENCO G, FALCHERO M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Liu, J, Trevisan, M, Menotti, A, THE RIFLE RESEARCH, Group, Lanti, M, Farchi, G, Conti, S, Seccareccia, F, Dima, F, Scanga, M, Marenco, G, Falchero, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1997

39. Mean levels and distributions of some cardiovascular risk factors in Italy in the 1970's and the 1980's. The Italian RIFLE Pooling Project. Risk Factors and Life Expectancy

Author

MENOTTI A, SECCARECCIA F, LANTI M, THE RIFLE PROJECT RESEARCH GROUP, FARCHI G, CONTI S, DIMA F, SCANGA M, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, MUSSI A, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Menotti, A, Seccareccia, F, Lanti, M, THE RIFLE PROJECT RESEARCH, Group, Farchi, G, Conti, S, Dima, F, Scanga, M, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Mussi, A, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1995

40. The prediction of coronary heart disease mortality as a function of major risk factors in over 30000 men in the Italian RIFLE Pooling Project. A comparison with the MRFIT primary screenees

Author

MENOTTI A, FARCHI G, SECCARECCIA F, THE RIFLE RESEARCH GROUP, CONTI S, GIAMPAOLI S, LANTI M, MARIOTTI S, SCANGA M, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Menotti, A, Farchi, G, Seccareccia, F, THE RIFLE RESEARCH, Group, Conti, S, Giampaoli, S, Lanti, M, Mariotti, S, Scanga, M, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1994

41. Presentation of the RIFLE Project Risk Factors and Life Expectancy

Author

THE RIFLE RESEARCH GROUP, MENOTTI A, FARCHI G, CONTI S, GIAMPAOLI S, LANTI M, MARIOTTI S, SCANGA M, SECCARECCIA F, SPAGNOLO A, VERDECCHIA A, DI CARLO G, DIMA F, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, TASSO S, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDATO S, DESCOVICH GC, DORMI A, BARBARA L, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, THE RIFLE RESEARCH, Group, Menotti, A, Farchi, G, Conti, S, Giampaoli, S, Lanti, M, Mariotti, S, Scanga, M, Seccareccia, F, Spagnolo, A, Verdecchia, A, DI CARLO, G, Dima, F, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, Tasso, S, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addato, S, Descovich, Gc, Dormi, A, Barbara, L, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1993

44. Helical CT angiography in gastrointestinal bleeding of obscure origin

Author

A P Garribba, A Greco, G. C. Ettorre, Farchi G, G. Francioso, and Fracella Mr

Subjects
Adult, Male, Gastrointestinal bleeding, medicine.medical_specialty, Contrast Media, Jejunum, medicine.artery, medicine, Image Processing, Computer-Assisted, Humans, Radiology, Nuclear Medicine and imaging, Angiodysplasia, Aged, medicine.diagnostic_test, business.industry, Vascular disease, Abdominal aorta, Angiography, General Medicine, Middle Aged, medicine.disease, Extravasation, Contrast medium, medicine.anatomical_structure, Female, Radiology, business, Gastrointestinal Hemorrhage, Tomography, X-Ray Computed, Extravasation of Diagnostic and Therapeutic Materials
Abstract

The aim of the study was to verify the usefulness of helical CT angiography for diagnosis of gastrointestinal hemorrhage of obscure origin.Eighteen consecutive patients underwent catheterization of the abdominal aorta followed by helical CT angiography before and after intraarterial injections of a contrast medium. Helical CT angiography revealed the site of hemorrhage as an extravasation of contrast medium resulting in a hyperdense area in the intestinal lumen. All patients then underwent conventional angiography that was selective for the 13 patients in whom helical CT angiography was positive and standard for the remaining five patients with negative helical CT angiograms.Helical CT angiography revealed the site of hemorrhage in 13 (72%) of 18 patients. Diagnosis of bleeding site was confirmed, and the cause was established at surgery in 11 of these 13 patients. The site of bleeding for the remaining two patients was confirmed by angiography as angiodysplasia of the jejunum (n = 1) and of the colon (n = 1). Of the five patients with negative helical CT angiograms, location of bleeding was revealed by conventional angiography in two patients; one of the remaining three patients underwent exploratory laparotomy; and bleeding ceased in the remaining two patients, who were treated without surgery. Conventional angiography was negative for two of the 13 patients in whom helical CT angiography was positive.Despite our limited experience, helical CT angiography proved to be an easier and faster technique than conventional angiography for localizing gastrointestinal bleeding of obscure origin and useful as a guide for subsequent selective conventional angiography.

Published
1997

46. L’impatto del consumo di alcol sulla salute degli italiani: Consumi, Prevalenze, Frazioni e Mortalità Attribuibili e Prevenibili, Strategie di Intervento, Italia 1985-1994

Author

Commissione mista del gruppo epidemiologico della societa' italiana di alcologia, Corrao, G, Zambon, A, Rubbiati, L, Bagnardi, V, Torchio, P, Addolorato, G, Aricò, S, La Vecchia, C, Braga, C, Caputo, F, Farchi, G, Taggi, F, Magliocchetti, N, Noventa, A, Salvagnini, M, Stefanini, Gf, Sabbadini, Ll, and Camporese, R

Subjects
NO
Published
1995

49. PRESENTATION OF THE RIFLE PROJECT RISK-FACTORS AND LIFE EXPECTANCY

Author

Menotti, A., Farchi, G., Conti, S., Giampaoli, S., Lanti, M., Mariotti, S., Scanga, M., Seccareccia, F., Spagnolo, A., Verdecchia, A., Dicarlo, G., Dima, F., Marenco, G., Falchero, M., Ideo, G., Caspani, B., Podda, M., Zuin, M., Ferrario, M., Cesana, Gc, Devito, G., Sega, R., Tenconi, Mt, Laddomada, Ms, Devoti, G., Dobrilla, G., Depetris, G., Angelini, Gp, Okolicsanyi, L., Toso, S., Nassuato, G., Passera, D., Ambrosio, Gb, Tasso, S., Bittolobon, G., Moro, E., Alessandrini, P., Soldan, S., Feruglio, Ga, Vanuzzo, D., Pilotto, L., Carulli, N., Loria, P., Dilengite, M., Bozzoli, M., Salvioli, Gf, Lugli, R., Gaddi, A., Sangiorgi, Z., Daddato, S., Minardi, A., Descovich, Gc, Dormi, A., Barbara, L., Festi, D., Alvisi, V., Balhous, W., Buzzelli, Gp, Giusti, A., Giacchi, M., Fatighenti, D., Giotti, M., Laurenzi, M., Ricci, G., Bucci, A., Antonini, R., Pacioni, F., Angelico, F., Delben, M., Lalloni, L., Azzarri, L., Ricci, P., Attili, Fa, Desantis, A., Urbinati, Gc, Fazio, S., Pannozzo, F., Sotis, Gl, Righetti, Gm, Mancini, M., Farinaro, E., Panico, S., Trevisan, M., Krogh, V., Jossa, F., Celentano, E., Rocco Galasso, Albano, O., Palasciano, G., Misciagna, G., Guerra, V., Muntoni, S., Pintus, P., Podda, E., Stabilini, M., Frulio, T., Brotzu, G., Pulina, S., Trudu, A., Sanna, A., Baule, Gm, Avellone, G., and Digarbo, V.

Subjects
RISK FACTORS, LIFE EXPECTANCY, MORTALITY, PREDICTION
Published
1993

50. CIND and MCI in the Italian elderly

Author

Di Carlo, A., primary, Lamassa, M., additional, Baldereschi, M., additional, Inzitari, M., additional, Scafato, E., additional, Farchi, G., additional, and Inzitari, D., additional

Published
2007
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