Search

Your search keyword '"FARAONE MENNELLA, MARIA ROSARIA"' showing total 370 results
Start Over Author "FARAONE MENNELLA, MARIA ROSARIA"

Refine your results

more »

more »

more »

more »
370 results on '"FARAONE MENNELLA, MARIA ROSARIA"'

17. A Glycosyltransferase from Sulfolobus solfataricus MT-4 Exhibits Poly(ADP-ribose) Glycohydrolase Activity

Author

DE MAIO, ANNA, PORZIO, ELENA, D'ANGELO, ROSA, CONFALONE, ELENA, NATALE, EMILIANA, FARAONE MENNELLA, MARIA ROSARIA, D, Rotondo, Sergio, Bianchi, Anna Rita, Raucci, Raffaele, DE MAIO, Anna, Porzio, Elena, D, D'Angelo, Rosa, Rotondo, Sergio, Bianchi, Anna Rita, Confalone, Elena, Raucci, Raffaele, Natale, Emiliana, and FARAONE MENNELLA, MARIA ROSARIA

Subjects
PARG, PARG, Sulfolobus solfataricus MT-4, PCR, biology, Biochemistry, Chemistry, ved/biology, Glycosyltransferase, Sulfolobus solfataricus, ved/biology.organism_classification_rank.species, biology.protein, Poly(ADP-ribose) glycohydrolase activity, Molecular Biology
Published
2015

22. Role of Cytoplasmic poly-ADP-ribosylation in Octopus vulgaris brain

Author

DE MAIO, ANNA, NATALE, EMILIANA, BIANCHI, ANNA RITA, DI COSMO, ANNA, FARAONE MENNELLA, MARIA ROSARIA, Poirer G.G., DE MAIO, Anna, Natale, Emiliana, Bianchi, ANNA RITA, DI COSMO, Anna, and FARAONE MENNELLA, MARIA ROSARIA

Subjects
vPARP, Octopus, Central Nervous System
Published
2013

23. An approach to nutrigenomics through epigenomics and lipidomics:comparing lymphocyte PARP levels/hyperactivation and erythrocyte membrane lipid composition with life style and clinical profiles of patients undergoing endoscopic surveillance

Author

Annarita Bianchi, Eugenio Barberis, Simona Ruggiero, Carla Ferreri, DE MAIO, ANNA, FARAONE MENNELLA, MARIA ROSARIA, FORMISANO, CESARE, GALLORO, GIUSEPPE, International Journal of Molecular Medicine, Bianchi, ANNA RITA, Eugenio, Barberi, Simona, Ruggiero, Formisano, Cesare, Galloro, Giuseppe, Carla, Ferreri, DE MAIO, Anna, and FARAONE MENNELLA, MARIA ROSARIA

Published
2013

24. Vault-poly-ADP-ribose polymerase in the Octopus vulgaris brain: A regulatory factor of actin polymerization dynamic

Author

DE MAIO, ANNA, NATALE, EMILIANA, DI COSMO, ANNA, FARAONE MENNELLA, MARIA ROSARIA, DE MAIO, ANA PAULA, Rotondo, S, DE MAIO, Anna, Natale, Emiliana, Rotondo, S, DI COSMO, Anna, FARAONE MENNELLA, MARIA ROSARIA, and DE MAIO, ANA PAULA

Subjects
Octopu, Brain, Oct-actin, Poly-ADP-ribose, vPARP
Abstract

Our previous behavioural, biochemical and immunohistochemical analyses conducted in selected regions (supra/sub oesophageal masses) of the Octopus vulgaris brain detected a cytoplasmic poly-ADP-ribose polymerase (more than 90% of total enzyme activity). The protein was identified as the vault-free form of vault-poly-ADP-ribose polymerase. The present research extends and integrates the biochemical characterization of poly-ADP-ribosylation system, namely, reaction product, i.e., poly-ADP-ribose, and acceptor proteins, in the O. vulgaris brain. Immunochemical analyses evidenced that the sole poly-ADP-ribose acceptor was the octopus cytoskeleton 50-kDa actin. It was present in both free, endogenously poly-ADP-ribosylated form (70. kDa) and in complex with V-poly-ADP-ribose polymerase and poly-ADP-ribose (260. kDa). The components of this complex, alkali and high salt sensitive, were purified and characterized. The kind and the length of poly-ADP-ribose corresponded to linear chains of 30-35 ADP-ribose units, in accordance with the features of the polymer synthesized by the known vault-poly-ADP-ribose polymerase. In vitro experiments showed that V-poly-ADP-ribose polymerase activity of brain cytoplasmic fraction containing endogenous actin increased upon the addition of commercial actin and was highly reduced by ATP. Anti-actin immunoblot of the mixture in the presence and absence of ATP showed that the poly-ADP-ribosylation of octopus actin is a dynamic process balanced by the ATP-dependent polymerization of the cytoskeleton protein, a fundamental mechanism for synaptic plasticity. © 2013 Elsevier Inc.

Published
2013

27. Is PARP2 involved in synaptic plasticity in L.stagnalis?

Author

Topo E., De Lisa M., Mistrtta C., Maurelli S., Winlow W., Syied N. I., DE MAIO, ANNA, FARAONE MENNELLA, MARIA ROSARIA, DI COSMO, ANNA, Faraone Mennella M.R., Topo, E., De Lisa, M., DE MAIO, Anna, Mistrtta, C., Maurelli, S., FARAONE MENNELLA, MARIA ROSARIA, Winlow, W., Syied, N. I., and DI COSMO, Anna

Subjects
monoADPribosio, PARP, ADP-ribosilazione
Abstract

Son state trattate tematiche riguardanti lo studio di vari aspetti dell reazione di ADP-ribosilazione in vari sistemi biologici.

Published
2011

29. A POSSIBLE ROLE OF POLY-ADPR METABOLISM IN SK-Mel28 CELLS TREATED WITH NBD-PEPTIDE

Author

MISTRETTA, CARMELA, FARAONE MENNELLA, MARIA ROSARIA, DE MAIO, ANNA, Natale E., Gentilcore G., Ascierto P. A., Faraone Mennella M. R., Mistretta, Carmela, Natale, E., Gentilcore, G., Ascierto, P. A., FARAONE MENNELLA, MARIA ROSARIA, and DE MAIO, Anna

Subjects
PARP, mono-ADPR, ADP-ribosilazione
Abstract

abstr. L11

Published
2011

30. ADP-RIBOSYLATION IN THE ARCHAEON S. solfataricus

Author

PORZIO, ELENA, FARAONE MENNELLA, MARIA ROSARIA, Mandrich L., Manco G., Corda D., Nicolaus B., Romano I., Faraone Mennella M. R., Porzio, Elena, Mandrich, L., Manco, G., Corda, D., Nicolaus, B., Romano, I., and FARAONE MENNELLA, MARIA ROSARIA

Subjects
PARP, mono-ADPR, ADP-ribosilazione
Abstract

abstr P11

Published
2011

34. Identificazione di nuove molecole coinvolte nei fenomeni di apprendimento di Lymnaea stagnalis

Author

Topo E., De Lisa E., DE MAIO, ANNA, FARAONE MENNELLA, MARIA ROSARIA, Willow W., Syed N. I., DI COSMO, ANNA, UZI, Topo, E., De Lisa, E., DE MAIO, Anna, FARAONE MENNELLA, MARIA ROSARIA, Willow, W., Syed, N. I., and DI COSMO, Anna

Subjects
apprendimento, SNC, Lymnaea stagnali, PARP
Abstract

I risultati ottenuti dimostrano, per la prima volta, una localizzazione citoplasmatica della PARP e suggeriscono la presenza dell'isoforma PARP2 nel SNC di L.stagnalis

Published
2011

36. Poly(ADP-ribosyl)ation of proteins is involved in the regulation of the cytoscheletal proteins in the central nervous system of Octopus vulgaris?

Author

DI COSMO, ANNA, DE MAIO, ANNA, Natale E., De Lisa E., FARAONE MENNELLA, MARIA ROSARIA, DI COSMO, Anna, DE MAIO, Anna, Natale, E., De Lisa, E., and FARAONE MENNELLA, MARIA ROSARIA

Subjects
CNS, PARP, Octopus vulgari
Abstract

The main results will be discussed in the light of a possible regulatory role played by PARP on actin polymerization/depolymerization in Octopus CNS

Published
2010

37. A DING Protein from S.solfataricus

Author

DE MAIO, ANNA, FARAONE MENNELLA, MARIA ROSARIA, Porzio, E, Mistretta, C, The Biochemical Society, London, DE MAIO, Anna, Porzio, E, Mistretta, C, and FARAONE MENNELLA, MARIA ROSARIA

Subjects
sulfolobus ding protein parp
Published
2010

40. PAR turnover in A375 melanoma cells treated with NBD peptide

Author

MISTRETTA, CARMELA, FARAONE MENNELLA, MARIA ROSARIA, Natale, E., Gentilcore, G., Ascierto, P., De Maio, A., Mistretta, Carmela, Natale, E., Gentilcore, G., Ascierto, P., FARAONE MENNELLA, MARIA ROSARIA, and De Maio, A.

Published
2010

42. The ADP-ribosylation of S. solfataricus Sso7 modulates protein/DNA interactions in vitro

Author

S. , Castellano, FARINA, BENEDETTA, FARAONE MENNELLA, MARIA ROSARIA, S., Castellano, Farina, Benedetta, and FARAONE MENNELLA, MARIA ROSARIA

Subjects
(ADP-ribosyl)ation, archaeon, Sso7, DNA-binding protein, Sulfolobu
Abstract

The 7 kDa Sso7 is a basic protein particularly abundant in Sulfolobus solfataricus and is involved in 28 DNA assembly. This protein undergoes in vitro ADP-ribosylation by an endogenous poly(ADP-ribose) 29 polymerase-like enzyme. The circular dichroism spectrum of purified ADP-ribosylated Sso7 shows 30 that this modification stabilizes the prevalent protein b-conformation, as suggested by shifting of 31 negative ellipticity minimum to 220 nm. Moreover, a short ADP-ribose chain (up to 6-mers) bound 32 to Sso7 is able to reduce drastically the thermoprotective and DNA condensing ability of the protein, 33 suggesting a possible regulatory role of ADP-ribosylation in sulfolobal DNA organization. 34 _ 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. 35

Published
2009

43. Detecting clinical activity in systemic lupus erythematosus with an archaeal poly(ADP-ribose) polymerase-like thermozyme: a pivotal study. PMID: 19530912 [PubMed - as supplied by publisher]

Author

FARAONE MENNELLA, MARIA ROSARIA, SCARPA, RAFFAELE, PELUSO, ROSARIO, FARINA, BENEDETTA, Petrella, A, Manguso, F, FARAONE MENNELLA, MARIA ROSARIA, Scarpa, Raffaele, Petrella, A, Manguso, F, Peluso, Rosario, and Farina, Benedetta

Subjects
lupu, sulfolobu, PARP
Abstract

The clinical usefulness of an immunotest was evaluated by using purified poly(adenosine diphosphate (ADP)-ribose) polymerase from Sulfolobus solfataricus (PARPSso) as an antigen to detect the presence of abnormal anti-PARP antibodies in the sera of patients with systemic lupus erythematosus (SLE) at different clinical stages. Sera from 44 patients with SLE, subgrouped on the basis of disease activity (16 with inactive disease, 28 with active disease) were analysed with a new immunotest to detect anti-PARP antibodies, and with an immunofluorescent (IIF) assay for antinuclear antibodies (ANA) detection. ANA detection by IIF revealed that sera of healthy subjects were negative, whereas sera from patients with SLE were positive in all cases (13 positive at 1:80, 15 at 1:160, 15 at 1:320, 1 at 1:640, v/v). Anti-PARP activity was higher in ANApositive patients than in controls (p = 0.005). Within the group of SLE sera, disease and anti-PARP activity was increased more significantly in patients with active than in those with inactive disease (p < 0.001 and p = 0.001, respectively). Correlation between anti-PARP and disease activity in SLE patients was statistically significant (p < 0.001). PARPSso seems to be suitable for detecting anti-PARP antibodies and could play a role as a serological marker of disease activity in patients with SLE.

Published
2009

46. PolyADP)ribosylation and cold tolerance in Cistus incanus L. plants

Author

MISTRETTA, CARMELA, ARENA, CARMEN, FARAONE MENNELLA, MARIA ROSARIA, DE MAIO, ANNA, Natale E., Comitato organizzatore, Mistretta, Carmela, Natale, Emiliana, Arena, Carmen, FARAONE MENNELLA, MARIA ROSARIA, DE MAIO, Anna, G. Mita, and Natale, E.

Subjects
cold, Mediterranean maquis, photochemistry, oxidative stress, Cold stress, PARP, Mediterranean environment, photochemistry
Published
2009

48. Nemo binding domain peptide could induce apoptosis in several melanoma cell lines

Author

DE MAIO, ANNA, MISTRETTA, CARMELA, FARAONE MENNELLA, MARIA ROSARIA, Capone, M., Natale, E., Gentilcore, G., Gravina, C., Di Martino, S., Simeone, E., Daponte, A., Caraco', C., Palmieri, G., Ascierto, P. A., DE MAIO, Anna, Capone, M., Natale, E., Gentilcore, G., Gravina, C., Mistretta, Carmela, Di Martino, S., Simeone, E., Daponte, A., Caraco', C., Palmieri, G., FARAONE MENNELLA, MARIA ROSARIA, and Ascierto, P. A.

Subjects
melanoma, cancer, PARP
Published
2009

49. NEMO-binding domain peptide inhibits proliferation of human melanoma cells

Author

IANARO, ANGELA, IALENTI, ARMANDO, M. Tersigni, Belardo G, Di Martino S, Napolitano M, Palmieri G, Sini M, DE MAIO, ANNA, Ombra M, Gentilcore G, Capone M, Ascierto M, Satriano RA, Farina B, FARAONE MENNELLA, MARIA ROSARIA, Ascierto PA, Ianaro, A, Tersigni, M, Belardo, G, Martino, Sd, Napolitano, M, Palmieri, G, Sini, M., DE MAIO, Anna, Ombra, M, Gentilcore, G, Capone, M, Ascierto, M, Satriano, Ra, Farina, B, FARAONE MENNELLA, MARIA ROSARIA, Ascierto, Pa, Ialenti, A., Ianaro, Angela, M., Tersigni, Di Martino, S, Sini, M, and Ialenti, Armando

Subjects
NEMO, melanoma
Abstract

Melanoma is the most aggressive form of skin cancer, it originates from melanocytes and its incidence has increased in the last decade. Recent advances in the understanding of the underlying biology of the progression of melanoma have identified key signalling pathways that are important in promoting melanoma tumourigenesis, thus providing dynamic targets for therapy. One such important target identified in melanoma tumour progression is the Nuclear Factor-kB (NF-kB) pathway. In vitro studies have shown that NF-kB binding is constitutively elevated in human melanoma cultures compared to normal elanocytes. It has been found that a short cell-permeable peptide spanning the IKK-beta NBD, named NBD peptide, disrupted the association of NEMO with IKKs in vitro and blocked TNFalpha-induced NF-kB activation in vivo. In the present study we investigated the effect of the NBD peptide on NF-kB activity and survival of A375 human melanoma cells. We found that NBD peptide is able to inhibit the proliferation of A375 cells, which present constitutively elevated NF-kB levels. Inhibition of cell proliferation by NBD peptide was associated with direct inhibition of constitutive NF-kB DNA-binding activity and induction of apoptosis by activation of caspase-3 as confirmed by the cleavage and consequently inactivation of poly (ADP ribose) polymerase (PARP-1) known as the best marker of this process.

Published
2009

50. PARP1 as apoptosis marker in A375 melanoma cells treated with NEMO binding domain peptide

Author

DE MAIO, ANNA, NATALE, EMILIANA, MISTRETTA, CARMELA, IANARO, ANGELA, FARAONE MENNELLA, MARIA ROSARIA, De Martino S., Napolitano M., Gentilcore G., Capone M., Tersigni M. R., Ascierto M. L., Ciccariello L., Palmieri G., Ialenti A., Ascierto P. A., Farina B., Di Girolamo M, DE MAIO, Anna, Natale, Emiliana, Mistretta, Carmela, De Martino, S., Napolitano, M., Ianaro, Angela, Gentilcore, G., Capone, M., Tersigni, M. R., Ascierto, M. L., Ciccariello, L., Palmieri, G., Ialenti, A., Ascierto, P. A., Farina, B., and FARAONE MENNELLA, MARIA ROSARIA

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results