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2 results on '"FACTOR (IGF)-BINDING PROTEINS"'

1. Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells

Subjects
des(1-3)-IGF-1, FACTOR-BINDING-PROTEIN, mRNA, CENTRAL-NERVOUS-SYSTEM, SELECTIVE AFFINITY, myelin proteins, survival, IGF-I, CEREBROSPINAL-FLUID, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, FACTOR (IGF)-BINDING PROTEINS, GROWTH-FACTOR-I, HUMAN NEUROBLASTOMA-CELLS, O2A cells, GENE-EXPRESSION
Abstract

Insulin-like growth factor 1 (IGF-1) is a growth and survival factor for oligodendrocyte lineage cells and promotes myelination. We demonstrate that IGF-binding protein 6 (IGFBP-6) is expressed and localized to the Golgi complex in rat oligodendrocyte precursor (O2A) cells. IGFBP-6 mRNA showed a developmentally regulated expression pattern, displaying a transient decrease during early development, and enhanced levels upon cell maturation. IGFBP-6 mRNA expression could be reduced by addition of basic fibroblast growth factor and progesterone while estrogen increased IGFBP-6 mRNA. IGF-1, platelet-derived growth factor, and insulin had no effect. When added exogenously, IGFBP-6 reduced O2A cell survival in the absence of IGF-1 and inhibited IGF-1-stimulated survival in a partially IGF-1-dependent and partially IGF-1-independent fashion. In addition, IGFBP-6 reduced the IGF-stimulated expression of two myelin proteins, CNPase and MAG. Taken together, the data show that IGFBP-6 is a new negative effector of oligodendrocyte survival and differentiation. (C) 2003 Wiley-Liss, Inc.

Published
2003

2. Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells

Author

Kuhl, NM, Hoekstra, D, De Vries, H, De Keyser, J, Gerontology, and Nanotechnology and Biophysics in Medicine (NANOBIOMED)

Subjects
FACTOR-BINDING-PROTEIN, mRNA, Cell Differentation/physiology, Insulin-Like-Growth-Factor-Binding Protein, SELECTIVE AFFINITY, myelin proteins, survival, Myelin-Assoc. Glycoprotein/antagonists, CEREBROSPINAL-FLUID, 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagon, GROWTH-FACTOR-I, HUMAN NEUROBLASTOMA-CELLS, Animals, O2A cells, Cell survival/physiology, GENE-EXPRESSION, des(1-3)-IGF-1, Cultured, 6/biosynthesis/genetics/physiology, CENTRAL-NERVOUS-SYSTEM, Developmental/physiology, IGF-I, Gene Expression Regulation, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, FACTOR (IGF)-BINDING PROTEINS, inhibitors/biosynthesis, CELLS, Growth Inhibitors/biosynthesis/genetics/physiology
Abstract

Insulin-like growth factor 1 (IGF-1) is a growth and survival factor for oligodendrocyte lineage cells and promotes myelination. We demonstrate that IGF-binding protein 6 (IGFBP-6) is expressed and localized to the Golgi complex in rat oligodendrocyte precursor (O2A) cells. IGFBP-6 mRNA showed a developmentally regulated expression pattern, displaying a transient decrease during early development, and enhanced levels upon cell maturation. IGFBP-6 mRNA expression could be reduced by addition of basic fibroblast growth factor and progesterone while estrogen increased IGFBP-6 mRNA. IGF-1, platelet-derived growth factor, and insulin had no effect. When added exogenously, IGFBP-6 reduced O2A cell survival in the absence of IGF-1 and inhibited IGF-1-stimulated survival in a partially IGF-1-dependent and partially IGF-1-independent fashion. In addition, IGFBP-6 reduced the IGF-stimulated expression of two myelin proteins, CNPase and MAG. Taken together, the data show that IGFBP-6 is a new negative effector of oligodendrocyte survival and differentiation. Copyright 2003 Wiley-Liss, Inc.

Published
2003

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