1. Red-Cell Auto-Antibodies Mimicking Anti-FybSpecificity
- Author
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M. A. M. Overbeeke, C. P. Engelfriet, M. B. Van't Veer, I. van Leeuwen, F.J.L.M. Haas, and M. Smelt
- Subjects
Erythrocytes ,Transfusion reaction ,Coombs test ,Antibody Specificity ,medicine ,Humans ,Autoantibodies ,A determinant ,medicine.diagnostic_test ,biology ,Red Cell ,Chemistry ,Autoantibody ,Transfusion Reaction ,Hematology ,General Medicine ,Middle Aged ,Molecular biology ,Coombs Test ,Red blood cell ,medicine.anatomical_structure ,Blood Grouping and Crossmatching ,Immunology ,Blood Group Antigens ,biology.protein ,Female ,Anemia, Hemolytic, Autoimmune ,Antibody ,Duffy Blood-Group System - Abstract
An antibody is described, produced by an Fy(a+b-) woman that at first reacted with her own cells, preferentially with Fy(b+) cells but not with Fy(a-b-) cells. Later, pure anti-Fyb specificity occurred. Elution and absorption studies revealed that the antibody recognized a determinant absent from Fy(a-b-) cells but present on Fy(a+b-) and Fy(a-b+) cells, much more strongly, however, on the latter, and that it was an autoantibody.
- Published
- 1984
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