1. Comparing calculated and experimental activity and dose values obtained from image-based quantification of 90Y SPECT/CT Data
- Author
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M. Diemling, A. Sohlberg, Alexander Haug, K. Lotter, H. Wiedner, and F.J. Maringer
- Subjects
Radiological and Ultrasound Technology ,Dose Calibrator ,Computer science ,Selective internal radiation therapy ,Biophysics ,Partial volume ,Collimator ,computer.software_genre ,Imaging phantom ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Voxel ,Dosimetry ,Radiology, Nuclear Medicine and imaging ,Correction for attenuation ,computer ,Biomedical engineering - Abstract
Purpose Selective internal radiation therapy (SIRT) is a treatment for various kinds of liver tumours by injecting 90 Y bearing microspheres into the liver vessels. To perform meaningful post-treatment dosimetry , quantitative imaging is performed. Methods This work uses a Monte-Carlo based reconstruction software with scatter and attenuation correction and collimator modelling that allows the quantification of 90 Y bremsstrahlung SPECT/CT data. A dataset comprising 17 patients and measurements on a Jaszczak phantom, a NEMA IEC Body phantom and an anthropomorphic liver phantom are analysed and activities and dose values are acquired. These measured values are compared with applied activities and pre-treatment calculations, allowing to assess the quality of the SPECT reconstruction. A detailed uncertainty budget is presented, including uncertainties of the dose calibrator, the count rate, non-included interactions and other factors. Results The applied method is validated by finding measurements repeatable within the given uncertainty, and it is shown the influence of various parameters on the reconstruction process is negligible. Furthermore, activities and doses measured in the phantoms show good agreement with calculated values, if they are corrected for partial volume effects . Conclusions The strict observation of metrological requirements and the creation of an uncertainty budget increase the reliability and traceability of this novel approach to 90Y dosimetry. It gives an example of successful voxel-based dosimetry based on quantitative 90Y SPECT/CT image data.
- Published
- 2021