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Purpose: To determine the predictors of all-cause mortality in patients with acute chest pain and negative troponin undergoing exercise echocardiography. Methods: A total of 1646 patients were referred to our chest pain unit for acute chest pain, nondiagnostic resting electrocardiograms and negative troponin I levels, and underwent exercise echocardiography within 24 hours of the chest pain episode. An abnormal exercise echocardiogram was defined as a peak wall motion score index (pWMSI) >1. The endpoint was all-cause mortality. Results: Mean age was 63.2±12.3 years, and 1068 patients were male. During an average follow-up of 2.35±1.50 years, 55 patients died. The 5-year mortality rate was 4.1% in patients with a normal exercise echocardiogram vs. 13.1% in those with abnormal results (p