1. The Statistical Significance of Mutation Frequencies
- Author
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U. Graf and F. F. Würgler
- Subjects
Statistics and Probability ,General Medicine ,Exact test ,symbols.namesake ,Sample size determination ,Region of interest ,Statistical significance ,Mutation (genetic algorithm) ,Statistics ,symbols ,Statistics, Probability and Uncertainty ,Mutation frequency ,After treatment ,Fisher's exact test ,Mathematics - Abstract
TRAUT has proposed a method for determining the statistical significance between a mutation frequency observed after treatment with a potential mutagen and a control frequency. The method is developed further by us for an easier practical use. A table for the minimal sample size in the region of interest for the sex-linked recessive lethal test in Drosophila melanogaster has been calculated. TRACT'S test is compared with FISHER'S exact test and the KASTENBAUM-BOWMAN test. TRAUT'S test turns out to be more sensitive than the other tests. This observation strongly supports TRAUT'S conclusion that his test should only be used if very accurate determinations of the spontaneous frequencies are available.
- Published
- 1982
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