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1. Seventh Annual Meeting of the European Association for the Study of Diabetes

Author

Bo Hellman, G. C. Palmieri, N. Mihalache, P. Siltanen, G. Bagnariol, W. K. Waldhäusl, M. Javicoli, U. Klör, F.A. Van Assche, M. Rathery, O. Melogli, D. Fedele, E. F. Pfeiffer, G. K. Rastogi, M. Bretán, R. R. de Mowbray, Poul Ebbe Nielsen, A. E. Lambert, Aa. Prange Hansen, Guido Tamburrano, J. C. Sodovez, B. Riveline, J. Canivet, Bartelt Km, S. Efendic, Franco Camanni, J. P. Bali, J. R. Claude, C. Rouiller, B. Schulz, M. Hinz, E. Eschwege, M. M. Mariani, M. Vigas, L. Kammerer, G. Enzi, M. Prud'homme, F. Massi-Benedetti, P. P. Foà, A. Ghidoni, I. M. Burr, L. Niklas, L. Nye, Sotirios Raptis, U. Brinck, B. Meyer, Hamish W. Sutherland, H. Laube, W. R. Drucker, B. Lesobre, H. J. Quabbe, M. A. Page, Åke Lernmark, Raimundo Goberna, M. Muggio, A. van't Laar, R. F. Murphy, Jens F. Rehfeld, Rolf Luft, C. E. Østerby, H. Karmann, K. E. Schröder, Ch. Thum, K. A. Munday, N. Mosora, Y. Kanazawa, D. P. Cameron, C. V. Tompkins, R. E. Levett, P. H. Sönksen, Domenico Andreani, R. D. M. Scott, P. J. Reeds, R. Fellin, A. Loubatières, M. J. Smith, J. Samsel, H. Iwatsuka, A. J. Valleron, S. Persson, K. Pyörälä, Victor Conard, J. M. Warnet, P. Polosa, R. Sparthe, A. Gordon, Y. Abdel Rahman, E. Fusco, Felix P. N. Schennetten, M. C. Srivastava, K. Johansen, D. Wübbens, F. Dauchy, Keith D. Buchanan, J. Marco, W. Teller, W. Poser, J. D. N. Nabarro, M. Rousselet, A. Hasselblatt, G. Rothenbuchner, H. Ørskov, G. M. Molinatti, J. Schönborn, A. Vitelli, A. M. McCarroll, Inge Bert Täljedal, M. Amherdt, R. Knussman, F. A. Gries, L. Orci, Beyer J, F. Jallet, J. Schlichtkrull, Z. Skrabalo, J. Vincze, W. Korp, Schöffling K, Ev. Kriedstein, E. B. Möller, J. Landon, S. Frezzato, H. Wingstrand, F. Massara, G. E. Rosselin, G. J. A. I. Snodgrass, H. L. Fehm, D. Michaelis, S. Le Guilcher, K. Seyer-Hansen, C. Kruger, D. M. Kipnis, J. Mirouze, María L. Villanueva, O. Oelz, P. J. Lefèbvre, V. Duma, Per Westermark, E. Giangrandi, M. R. Turner, H. Bibergeil, G. R. Brisson, J. Birk, T. Mincu, I. M. Baroja, M. R. P. Hall, G. Wick, Patricia Metzger, Werner Oppermann, E. Jutzi, Guido Pozza, P. Jacquet, A. Kopf, J Ostman, N. Conte, R. Fuchs, Theodore Ehrenreich, I. Mincu, Barbara Rudas, A. S. Luyckx, A. E. Renold, A. Schirmann, U. Klemens, R. E. Haist, V. Nuteanu, L. Papoz, R. Spaethe, G. Tohobroutsky, W. Hildmann, V. Gligore, B. Morell, G. Tchobroutsky, Willy Malaisse, J. Sterne, G. Löffler, N. S. Track, E. B. Marliss, EskoA. Nikkilä, C. R. C. Heard, Tr. Baciu, F. Fallucca, E. Krug, J. Trap-Jensen, Isabel Valverde, Rafael A. Camerini-Davalos, S. Klahr, L. Stimmler, C. Rosak, M. Motocou, K. W. Taylor, H. Otto, O. Wieland, K. Lundbak, Th. Koschinsky, R. Assan, E. Cerasi, M. Toeller, S. Triggs, W. Stauffacher, Haupt E, R. J. Dash, C. Scandellari, E. R. Froesch, F. J. Woodroffe, L. Balant, M. Verry, M. Lunetta, A. Tiengo, D. G. Parry, L. Weiss, M. Kikuchi, Uwe Panten, G. C. Viberti, B. Blondel, J. D. Teale, J. C. Dunbar, N. S. Bricker, C. E. Ruth, M. K. Sinha, W. Braun, M.R. Taskinen, D. H. Williamson, U. Loos, O. Steingaszner, Giovanni Federspil, L. Herberg, S. Georgescu, R. Fussgänger, J. Hewitt, A. L. Bergström, S. Levin Nielsen, H. Schatz, E. Lehtovirta, Jurgen Steinke, I. Lozano, F. Sodovez-Goffaux, D. R. Langslow, E. Speich, I. Neumann, G. Menzinger, A. Tinant, S. Munkgaard Rasmussen, Janove Sehlin, C. Dumitrescu, N. Katsilambros, A. Tognetti, Ligia Simionesco, C. Oliver, C. E. Mogensen, A. E. Pappalettera, P. Vague, K. Sträub, L. Motta, J. Vague, A. Orsetti, Mme A. Serre, B. M. Freeman, A. Trisotto, R. Korec, M. Diaz-Fierros, F. Stadil, S. Campeanu, J. Sabin, H. P. T. Ammon, P. Mialhe, F. Legros, C. Rogister, R. Schröder, V. Maier, Risto Pelkonen, F. Scaroina, M. Parvulescu, and K. E. Schenk

Subjects
medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Association (object-oriented programming), Family medicine, Ophthalmology, Diabetes mellitus, Internal Medicine, medicine, Human physiology, business, medicine.disease
Published
1972
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2. A follow-up on functional parameters of blood stored in ACD at +4 degrees C

Author

F, Scaroina, M C, Amprimo, F, Zola, L, Cavallari, L, Milanesio, G, Bonetti, E, Rabino Massa, and G, Ricco

Subjects
2,3-Diphosphoglycerate, Cold Temperature, Erythrocytes, Glucose, Time Factors, Blood Preservation, Humans, Diphosphoglyceric Acids, Citric Acid
Abstract

The main functional parameters of blood stored at +4 degrees C in ACD, according to the common transfusional practice, have been carefully followed in the course of 40 days. The expected depletion of DPG takes place within 10 days, but apparently, no increase of the Hb affinity towards oxygen is observed in this period (or later), because pH lowering acts in the opposite direction during the same time. However, the intrinsic increased affinity of Hb is promptly revealed if the "actual" pHs are corrected at the standard value of 7.4, and/or are extrapolated at this pH from Bohr effect.

Published
1989

3. [Treatment of hyperlipemia with tibric acid (TA)]

Author

L, De Rosa, E, Giangrandi, N, Murante, and F, Scaroina

Subjects
Adult, Cholesterol, Piperidines, Humans, Hyperlipidemias, Clofibrate, Lipoproteins, VLDL, Middle Aged, Triglycerides
Published
1978

4. Hb-CO in normal adults and newborns

Author

F, Scaroina, L, Cavallari, M C, Amprimo, G, Scano, E, Rabino-Massa, C, Fabris, and G, Ricco

Subjects
Adult, Aging, Carboxyhemoglobin, Infant, Newborn, Humans
Published
1987

10. Further studies on functional differences between adult and neonatal blood

Author

C, Fabris, E, Rabino-Massa, F, Scaroina, L, Cavallari, M C, Amprimo, F, Zola, C, Oneglia, and G, Ricco

Subjects
Adult, Male, Oxygen, Hemoglobins, Reference Values, Oxyhemoglobins, Infant, Newborn, Humans, Female, Hydrogen-Ion Concentration, Blood Physiological Phenomena, Fetal Blood, Veins
Published
1987

12. [Findings on proteinuria in selected diabetic patients. Relation to microangiopathy and its prognostic significance]

Author

F, Scaroina, P, Martino, and M, Gai

Subjects
Adult, Diabetes Complications, Male, Proteinuria, Adolescent, Hypertension, Humans, Kidney Failure, Chronic, Female, Middle Aged, Diabetic Angiopathies, Aged
Abstract

Urinary protein is usually above normal in diabetics, even when the disease is of recent onset. Values tend to move further away from physiological levels as the condition persists. Electrophoresis reveals a selective glomerular form, even in many subjects with a quantitatively normal picture and free of signs of micro- and macroangiopathy, as these are commonly defined, whereas non-selective glomerular proteinuria is observed in patients with micro- or macroangiopathic lesions, such as marked changes in renal clearance, intense proteinuria, hypertension, chronic renal failure. It is suggested that careful evaluation of urinary proteins can be usefully associated with examination of the fundus to obtain early warning of microangiopathic lesions in the two target organs, i.e. the kidneys and retinae.

Published
1981

13. [Insulinemia in subjects older than 80 years]

Author

P G, De Filippi, F, Scaroina, and A, Vitelli

Subjects
Adult, Blood Glucose, Adolescent, Arteriosclerosis, Age Factors, Glucose Tolerance Test, Antigen-Antibody Reactions, Photometry, Diabetes Mellitus, Humans, Insulin, Female, Antigens, Aged
Published
1974

14. Molecular characterization and functional studies on Hb Kempsey, beta 99 (G-1) Asp----Asn, a high-oxygen affinity variant.

Author

Ricco G, Scaroina F, Amprimo MC, Gottardi E, Parziale A, Alfarano A, and Camaschella C

Subjects
Aged, Amino Acid Sequence, Base Sequence, DNA Mutational Analysis, Female, Heterozygote, Humans, Male, Molecular Sequence Data, Oxyhemoglobins metabolism, Polycythemia blood, Polycythemia genetics, Protein Structure, Tertiary, Hemoglobins, Abnormal metabolism, Oxygen metabolism
Abstract

Background: Hb Kempsey (beta 99 Asp----Asn) is a high-oxygen affinity hemoglobin, never before reported in Italy, associated with secondary erythrocytosis. It has been found in the heterozygous state in two subjects from the same family originating from the Verona area in Northern Italy., Methods: The abnormal hemoglobin was studied both at the protein and at the DNA level. The amino acid substitution was identified by fingerprinting and amino acid analysis. The nucleotide replacement was investigated by means of polymerase chain reaction (PCR) of the beta gene and direct sequencing. Oxygen affinity and other functional parameters were assessed on whole blood and on the separate hemoglobin fractions., Results: These studies allowed us to establish the molecular substitution GAT (Asp)----AAT (Asn) at codon 99. Functional studies revealed a left-shifted and biphasic dissociation curve of the proposita, with a very low p50. The two carriers of this hemoglobinopathy have different degrees of polyglobulia, since iron deficiency in one of them reduces total and abnormal Hb., Conclusions: The compensatory mechanisms for tissue hypoxia are discussed with the conclusion that erythrocytosis has to be preserved in these patients to maintain adequate tissue oxygenation.

Published
1992

15. Further studies on oxygen loading in blood from anemic patients.

Author

Rabino Massa E, Scaroina F, Cavallari L, Amprimo MC, Zola F, Bonetti G, and Ricco G

Subjects
2,3-Diphosphoglycerate, Carbon Dioxide blood, Diphosphoglyceric Acids blood, Female, Humans, Hydrogen-Ion Concentration, Male, Regression Analysis, Sex Factors, Anemia blood, Hemoglobins analysis, Oxygen blood
Abstract

Functional parameters of the whole blood oxygen loading from 66 anemic subjects, compared with those from 66 normal adult of both sexes display the following behaviour: a) Adult males and females differ for p50 values, which are higher in females because of their lower Hb level. This difference is already well known and appears to be statistically significant. b) The same difference is amplified in anemic subjects, where also pH lowering contributes to the right-shift of p50. c) The inverse relationship between p50 and DPG values differs if analysed at the actual pHs, at pH corrected at 7.4, or extrapolated from Bohr effect. In fact, the three relative plots do not parallel, and their most significant intersects drop around 0.8-0.9 value of DPG, and 26-27 torr of p50, i.e. within normal limits.

Published
1990

16. [Treatment of hyperlipemia with tibric acid (TA)].

Author

De Rosa L, Giangrandi E, Murante N, and Scaroina F

Subjects
Adult, Cholesterol blood, Clofibrate administration & dosage, Humans, Lipoproteins, VLDL blood, Middle Aged, Piperidines pharmacology, Triglycerides blood, Hyperlipidemias drug therapy, Piperidines therapeutic use
Published
1978

18. Further studies on functional differences between adult and neonatal blood.

Author

Fabris C, Rabino-Massa E, Scaroina F, Cavallari L, Amprimo MC, Zola F, Oneglia C, and Ricco G

Subjects
Adult, Female, Hemoglobins analysis, Humans, Hydrogen-Ion Concentration, Infant, Newborn, Male, Oxygen blood, Oxyhemoglobins metabolism, Reference Values, Veins, Blood Physiological Phenomena, Fetal Blood physiology
Published
1987

20. Functional properties of the unstable Hb-Torino: alpha 43 (CD-1) Phe-Val.

Author

Ricco G, Scaroina F, Burzio P, Bertello PD, Vietti-Ramus G, Gallione S, Gurioli L, and Montinaro E

Subjects
Anemia, Hemolytic genetics, Heterozygote, Humans, Hydrogen-Ion Concentration, Oxyhemoglobins metabolism, Anemia, Hemolytic blood, Hemoglobins, Abnormal analysis
Published
1985

22. A follow-up on functional parameters of blood stored in ACD at +4 degrees C.

Author

Scaroina F, Amprimo MC, Zola F, Cavallari L, Milanesio L, Bonetti G, Rabino Massa E, and Ricco G

Subjects
2,3-Diphosphoglycerate, Cold Temperature, Erythrocytes drug effects, Glucose pharmacology, Humans, Time Factors, Blood Preservation, Citric Acid, Diphosphoglyceric Acids analysis, Erythrocytes analysis, Glucose analogs & derivatives
Abstract

The main functional parameters of blood stored at +4 degrees C in ACD, according to the common transfusional practice, have been carefully followed in the course of 40 days. The expected depletion of DPG takes place within 10 days, but apparently, no increase of the Hb affinity towards oxygen is observed in this period (or later), because pH lowering acts in the opposite direction during the same time. However, the intrinsic increased affinity of Hb is promptly revealed if the "actual" pHs are corrected at the standard value of 7.4, and/or are extrapolated at this pH from Bohr effect.

Published
1989

23. Hb-CO in normal adults and newborns.

Author

Scaroina F, Cavallari L, Amprimo MC, Scano G, Rabino-Massa E, Fabris C, and Ricco G

Subjects
Adult, Humans, Infant, Newborn, Aging blood, Carboxyhemoglobin metabolism
Published
1987

25. [Findings on proteinuria in selected diabetic patients. Relation to microangiopathy and its prognostic significance].

Author

Scaroina F, Martino P, and Gai M

Subjects
Adolescent, Adult, Aged, Female, Humans, Hypertension etiology, Kidney Failure, Chronic etiology, Male, Middle Aged, Diabetes Complications, Diabetic Angiopathies complications, Proteinuria etiology
Abstract

Urinary protein is usually above normal in diabetics, even when the disease is of recent onset. Values tend to move further away from physiological levels as the condition persists. Electrophoresis reveals a selective glomerular form, even in many subjects with a quantitatively normal picture and free of signs of micro- and macroangiopathy, as these are commonly defined, whereas non-selective glomerular proteinuria is observed in patients with micro- or macroangiopathic lesions, such as marked changes in renal clearance, intense proteinuria, hypertension, chronic renal failure. It is suggested that careful evaluation of urinary proteins can be usefully associated with examination of the fundus to obtain early warning of microangiopathic lesions in the two target organs, i.e. the kidneys and retinae.

Published
1981

27. [Insulinemia in subjects older than 80 years].

Author

De Filippi PG, Scaroina F, and Vitelli A

Subjects
Adolescent, Adult, Age Factors, Aged, Antigen-Antibody Reactions, Antigens, Arteriosclerosis immunology, Blood Glucose, Diabetes Mellitus immunology, Female, Glucose Tolerance Test, Humans, Insulin immunology, Photometry, Insulin blood
Published
1974

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