21 results on '"F. Ressico"'
Search Results
2. Subduction hides high-pressure sources of energy that may feed the deep subsurface biosphere
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I. Daniel, Donato Giovannelli, Francesca Piccoli, F. Ressico, A. Vitale Brovarone, Dimitri A. Sverjensky, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Vitale Brovarone, A., Sverjensky, D.A., Piccoli, F., Ressico, F., Giovannelli, D., Daniel, I., and Sverjensky, D. A.
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0301 basic medicine ,Chemical Phenomena ,Earth science ,General Physics and Astronomy ,02 engineering and technology ,Hydrogen Sulfide ,Organic Chemicals ,lcsh:Science ,Abiotic component ,Minerals ,Multidisciplinary ,Subduction ,Biosphere ,Deep energy, Subduction, Serpentinization ,Carbon cycle ,021001 nanoscience & nanotechnology ,Thermodynamics ,Organic Chemical ,0210 nano-technology ,Methane ,Geology ,Geological Phenomena ,Science ,Secologanin Tryptamine Alkaloid ,Volcanic Eruptions ,Geodynamics ,Article ,General Biochemistry, Genetics and Molecular Biology ,Mantle (geology) ,03 medical and health sciences ,Ammonia ,550 Earth sciences & geology ,Mineral ,Forearc ,Ecosystem ,Mechanical Phenomena ,Tectonics ,General Chemistry ,Volcanic Eruption ,Secologanin Tryptamine Alkaloids ,Organic Chemistry Phenomena ,Geochemistry ,030104 developmental biology ,[SDU]Sciences of the Universe [physics] ,lcsh:Q ,Hydrogen - Abstract
Geological sources of H2 and abiotic CH4 have had a critical role in the evolution of our planet and the development of life and sustainability of the deep subsurface biosphere. Yet the origins of these sources are largely unconstrained. Hydration of mantle rocks, or serpentinization, is widely recognized to produce H2 and favour the abiotic genesis of CH4 in shallow settings. However, deeper sources of H2 and abiotic CH4 are missing from current models, which mainly invoke more oxidized fluids at convergent margins. Here we combine data from exhumed subduction zone high-pressure rocks and thermodynamic modelling to show that deep serpentinization (40–80 km) generates significant amounts of H2 and abiotic CH4, as well as H2S and NH3. Our results suggest that subduction, worldwide, hosts large sources of deep H2 and abiotic CH4, potentially providing energy to the overlying subsurface biosphere in the forearc regions of convergent margins., Geological sources of H2 and abiotic CH4 have had a critical role in the evolution of life and sustainability of the deep subsurface biosphere, yet the origins of these sources remain largely unconstrained. Here the authors show that deep serpentinization (40–80 km) during subduction generates significant amounts of H2 and abiotic CH4, potentially providing energy to the overlying subsurface biosphere.
- Published
- 2020
3. Alexithymia, empathy, emotion identification and social inference in anorexia nervosa: A case-control study
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Anna Palazzolo, Massimiliano Mazzarino, Roberta Siliquini, Carla Gramaglia, Eleonora Gambaro, Fabrizio Bert, Patrizia Zeppegno, and F. Ressico
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Adult ,Male ,Alexithymia ,050103 clinical psychology ,animal structures ,Psychotherapist ,media_common.quotation_subject ,Emotions ,Personal distress ,Inference ,Empathy ,Emotion identification ,Interpersonal communication ,03 medical and health sciences ,Social inference ,0302 clinical medicine ,medicine ,Humans ,0501 psychology and cognitive sciences ,Affective Symptoms ,Reactivity (psychology) ,Anorexia nervosa, Alexithymia, Empathy, Emotion identification, Social inference ,media_common ,05 social sciences ,Anorexia nervosa ,Awareness ,Middle Aged ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,Expression (architecture) ,Anorexia nervosa (differential diagnoses) ,Case-Control Studies ,Female ,Psychology ,Clinical psychology - Abstract
Alexithymia, difficulties in facial emotion recognition, poor socio-relational skills are typical of anorexia nervosa (AN). We assessed patients with AN and healthy controls (HCs) with mixed stimuli: questionnaires (Toronto Alexithymia Scale-TAS, Interpersonal Reactivity Index-IRI), photographs (Facial Emotion Identification Test-FEIT) and dynamic images (The Awareness of Social Inference Test-TASIT). TAS and IRI Personal Distress (PD) were higher in AN than HCs. Few or no differences emerged at the FEIT and TASIT, respectively. Larger effect sizes were found for the TAS results. Despite higher levels of alexithymia, patients with AN seem to properly acknowledge others' emotions while being inhibited in the expression of their own.
- Published
- 2016
4. Perinatal and Neonatal Outcomes of Lithium-Treated and Untreated Bipolar Women During Pregnancy: A Review of Present Literature
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Eugenio Torre, Valentina Dalo, I. Coppola, F. Ressico, C. Gramaglia, M.C. Rizza, and P. Zeppegno
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Pharmacology ,Psychiatry and Mental health ,Pregnancy ,Pediatrics ,medicine.medical_specialty ,Lithium (medication) ,Neonatal outcomes ,business.industry ,medicine ,Pharmacology (medical) ,medicine.disease ,business ,medicine.drug - Published
- 2013
5. An Observational Study of Venlafaxine and CYP2D6 in Clinical Practice
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Carla Gramaglia, Eugenio Torre, Valentina Dalo, F. Ressico, Matteo Vidali, Roberta Rolla, Silvia Meola, Paola Pollarolo, Patrizia Zeppegno, Pierluigi Prosperini, and Giorgio Bellomo
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Adult ,Male ,CYP2D6 ,medicine.medical_specialty ,Venlafaxine ,digestive system ,General Biochemistry, Genetics and Molecular Biology ,Therapeutic index ,Internal medicine ,medicine ,Humans ,Practice Patterns, Physicians' ,skin and connective tissue diseases ,Adverse effect ,Genotyping ,Aged ,Depressive Disorder, Major ,business.industry ,Venlafaxine Hydrochloride ,Middle Aged ,Cyclohexanols ,medicine.disease ,Phenotype ,Cytochrome P-450 CYP2D6 ,Clinical Global Impression ,Major depressive disorder ,Female ,Reuptake inhibitor ,business ,medicine.drug - Abstract
BACKGROUND: Venlafaxine (V) is a serotonin-norepinephrine selective reuptake inhibitor, mainly metabolized by cytochrome P4502D6 (CYP2D6). CYP2D6 polymorphisms result in a variety of phenotypes: poor (PMs), intermediate (IMs), extensive (EMs), and ultrarapid metabolizers (UMs). PMs usually show poor tolerance to drugs metabolized by CYP2D6, while UMs need greater doses. The aim of this study was to evaluate the impact of CYP2D6 genotype on V dosage, therapeutic response, and side effects in a clinical outpatient setting. METHODS: 47 patients with Major Depressive Disorder, treated with V 75 - 300 mg/day, underwent CYP2D6 genotyping using the INFINITI-CYP2D6 assay. Duration of treatment and clinical outcome (Clinical Global Impression [CGI] effectiveness index) were assessed. RESULTS: CGI assessment was performed after 6 weeks, 6 months, and 1 year of treatment with a V median dose of 150 mg/day. CYP2D6 genotyping resulted in 1 PM, 3 IMs, 42 EMs, and 1 UM. The UM took the greatest V dose (375 mg) without side effects; IMs/PMs took moderate/high doses of V (150 - 300 mg) without adverse effects; EMs displayed high response variability. CONCLUSIONS: PM/IM patients responded to V differently than expected according to genotype. However, the UM patient responded to a dosage higher than the usual therapeutic range and without developing side effects, suggesting an association between CYP2D6 gene duplication and the therapeutic efficacy of venlafaxine. The CYP2D6 genotyping may thus provide clinicians with a potential explanation for those patients requiring greater doses of CYP2D6 substrates in order to obtain the same therapeutic efficacy.
- Published
- 2014
6. Early onset frontotemporal dementia with psychiatric presentation due to the C9ORF72 hexanucleotide repeat expansion: A case report
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Miryam Carecchio, Patrizia Zeppegno, M.C. Rizza, Roberto Cantello, Emanuela Terazzi, Nunzia Chieppa, F. Ressico, Carla Gramaglia, and Sandra D'Alfonso
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medicine.medical_specialty ,Neurology ,Clinical Neurology ,Neurological examination ,Case Report ,Behavioural variant ,C9orf72 ,mental disorders ,medicine ,Dementia ,Humans ,Family history ,Psychiatry ,DNA Repeat Expansion ,medicine.diagnostic_test ,C9orf72 Protein ,business.industry ,C9Orf72 ,Frontotemporal dementia ,Psychiatric presentation ,nutritional and metabolic diseases ,Proteins ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,nervous system diseases ,Positron-Emission Tomography ,Mutation ,Female ,Neurology (clinical) ,Trinucleotide repeat expansion ,business - Abstract
Background Frontotemporal dementia (FTD) may present with psychiatric symptoms, usually together with neurological ones and in cases with a family history of dementia. We describe the case of an FTD behavioural variant with a psychiatric presentation and a normal neurological examination, due to a C9Orf72 gene mutation. Case presentation The patient was a 57 years-old Caucasian woman with a recent onset of bizarre behaviours and mystic delusions. She had a negative clinical history for previous psychiatric disorders and treatments and this was her first admission to a Psychiatry Ward. A careful assessment was performed including, beyond psychiatric evaluation, the following: blood sampling, neurological examination (including electroencephalogram, electroencephalogram with zygomatic electrodes, Positron Emission Tomography, Cerebrospinal Fluid Analysis), carotid artery Doppler ultrasound, brain Magnetic Resonance Imaging – angio Magnetic Resonance Imaging. Blood sampling for the genetic assessment of mutations associated to primary dementias was performed as well: the genes investigated were FUS, C9Orf72, PSEN-1, PSEN-2. Conclusions Serological tests were negative, neurological examination was normal, instrumental examinations showed theta waves in the posterior temporal areas bilaterally and frontotemporal cortical atrophy bilaterally. The genetic assessment of mutations associated revealed she carried a GGGGCC hexanucleotide repeat expansion (at least 80 repeats) in C9Orf72 intron 1. Patients carrying the C9Orf72 mutation are likely to receive a psychiatric diagnosis (mainly mood disorder or schizophrenia) prior to correct diagnosis; this may be particularly problematic for those patients with no neurological signs to orientate diagnosis. Understanding the manner in which such FTD variant may present as a psychiatric syndrome, with a negative neurological examination, is essential to provide the best treatment for patients, as soon as possible, especially when the behavioural anomalies interfere with their care.
- Published
- 2014
7. EPA-0757 – Predictors of suicidal behaviours: analysis of four years of emergency room psychiatric consultation
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F. Ressico, G.C. Avanzi, Luigi Mario Castello, Carla Gramaglia, I. Coppola, and Patrizia Zeppegno
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Psychiatry and Mental health ,medicine.medical_specialty ,Multivariate analysis ,Psychiatric consultation ,business.industry ,Statistical significance ,Medicine ,Suicide mortality rate ,Odds ratio ,business ,Psychiatry ,Logistic regression ,Confidence interval - Abstract
Purpose The annual global suicide mortality rate is 16 per 100,000 and suicide attempts are 20 times more frequent. We aimed at comparing patients referring to the emergency room (ER) for self-inflicted injury vs those needing psychiatric consultation for other reasons, in order to assess possible predictors of self-injury. Methods Determinants of ER psychiatric consultations were studied prospectively during the period 2008–2011 at the ‘Maggiore’ Hospital in Novara. A multivariate analysis was performed using a logistic regression in order to assess the potential predictors of self-injury behaviors. Results are expressed as Odds Ratio (OR) with 95% Confidence Intervals (95%CI). Statistical significance was set at p≤0.05. Results In a sample of 1888 psychiatric consultations, 280 (14.8%) were due to self-inflicted injuries . Female gender (OR: 1.51; p=0.005) was found to positively correlate with attempted suicides, whereas unemployment (OR: 0.68; p=0.013) and being in the colder months of the year (OR: 0.75; p=0.043) were found to be negative correlated. A positive trend without statistical significance was observed for foreign nationality, being not married and living with parents/own family vs a negative trend was found for history of psychiatric disorders. Conclusions In accordance with other studies, we observed the female gender positively correlates with attempted suicides and sunlight may act as a trigger. In contrast with literature, individuals with a permanent job would be at higher risk of self-injury behaviours, whereas having a history of psychiatric disorders and being under the care of a psychiatrist might be a protective predictor.
- Published
- 2014
8. EPA-0777 – Alexithymia, facial emotion identification and social inference in ed patients: a case-control study
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S. Gili, M.C. Rizza, F. Ressico, Patrizia Zeppegno, A. Feggi, P. Prosperini, Eleonora Gambaro, and Carla Gramaglia
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medicine.medical_specialty ,medicine.diagnostic_test ,Beck Depression Inventory ,medicine.disease ,Emotional dysregulation ,Eating Disorder Inventory ,Psychiatry and Mental health ,Toronto Alexithymia Scale ,Eating disorders ,Alexithymia ,medicine ,Temperament and Character Inventory ,Binge Eating Scale ,Psychiatry ,Psychology ,Clinical psychology - Abstract
Introduction Alexythimia, reduced cognitive empathy and emotion awareness and understanding are present among individuals with Eating Disorders (EDs). Facial expression is a reliable marker of emotion and an important source of social information. Thus, the ability to judge facial expression is essential for successful interpersonal interactions. Objectives To evaluate alexythimia, facial emotion identification and social inference abilities in a sample of ED patients, compared to a sample of patients with another psychiatric diagnosis and a group of healthy controls, matched by gender and age. Aims To describe a specific pattern of emotional dysregulation in ED patients. Methods ED patients and the Psychiatric Control Group are recruited at the Institute of Psychiatry in Novara, while healthy controls are recruited on a community basis. All patients and controls are females, aged 18–65. All patients are undergoing the Structured Clinical Interview for DSM-IV -Patient version (SCID-I-P), healthy controls are administered the Structured Clinical Interview for DSM-IV – Non Patient version (SCID-I-NP). All subjects are undergoing the following: SCID-II, Eating Disorder Inventory − 3 (EDI-3), Binge Eating Scale (BES), Beck Depression Inventory (BDI), Symptom Checklist − 90 (SCL-90), Facial Emotion Identification Test (FEIT), The Awareness of Social Inference Test (TASIT), Temperament and Character Inventory (TCI), Rosenberg Self-Esteem Scale (RSES), Interpersonal Reactivity Index (IRI), Toronto Alexithymia Scale (TAS-20). Results The recruitment and analysis of the samples are ongoing. The ED sample is expected to show greater alexythimia and a poorer performance at FEIT and TASIT, compared to the control samples. Conclusions Clinical implications will be discussed.
- Published
- 2014
9. 1688 – Suicidal behaviours and occupational status: a preliminary analysis of emergency room psychiatric consultation
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C. Gramaglia, I. Coppola, F. Ressico, and P. Zeppegno
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medicine.medical_specialty ,business.industry ,Public health ,Occupational prestige ,Qualitative property ,Test (assessment) ,Preliminary analysis ,Psychiatry and Mental health ,Exact test ,Psychiatric consultation ,medicine ,Accommodation status ,Psychiatry ,business ,Clinical psychology - Abstract
Introduction Suicidal behaviours are major public health concerns, associated with many risk factors that vary with sociodemographical features. Objectives To compare the differences between patients visiting the emergency room (ER) for self-inflicted injury vs those needing psychiatric consultation for other reasons, as far as their occupational and accommodation status are concerned. Aims To evaluate the influence of the economic scenery on suicidal behaviours. Methods Determinants of ER psychiatric consultations were studied prospectively from 2008 to 2011 at the “Maggiore” Hospital in Novara. Comparison of qualitative data was performed by means of the x 2 test, or the Fisher’s Exact test in case of expected frequencies less than 5. All tests were two-sided and a P value less than 0.05 was considered as statistically significant. Results In a sample of 1888 psychiatric consultations, 281 (14.9%) were due to self-inflicted injuries. The preliminary analysis of socio-demographical features showed that self-harm behaviours are significantly more frequent among employed vs unemployed or disabled subjects (20.1% vs 13.2%; p=0.0005) and among those living in their immediate or own family vs those living alone or in therapeutic facilities (17.0% vs 13.0% vs 8.4%; p=0.012). Conclusions In contrast to current literature, our study shows that individuals living in more favourable conditions are at greater risk of attempting suicide. These results might be associated to the current Italian economic scenery, and to emerging difficulties as far as keeping an income to adequately maintain a family are concerned.
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- 2013
10. Venlafaxine and CYP2D6 in clinical practice: An observational study
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G. Bellomo, A. Parafioriti, P. Prosperini, V. Dalò, Roberta Rolla, F. Ressico, Eugenio Torre, and Patrizia Zeppegno
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Treatment response ,medicine.medical_specialty ,CYP2D6 ,business.industry ,Venlafaxine ,medicine.disease ,Clinical Practice ,Psychiatry and Mental health ,Internal medicine ,Medicine ,Observational study ,Bipolar disorder ,business ,Adverse effect ,Psychiatry ,Active metabolite ,medicine.drug - Abstract
IntroductionVenlafaxine is a serotonin-norepinephrine inhibitor, mainly metabolized by CYP2D6 to its active metabolite ODV. Depending on CYP2D6 activity, patients may be identified as Poor, Intermediate, Extensive or Ultrarapid Metabolizers. There is some evidence that a PM phenotype is associated with poor tolerance more often than an EM; while a UM patient would only respond to a greater dose of Venlafaxine1.ObjectivesTo evaluate the impact of CYP2D6 phenotype on the efficacy of Venlafaxine XR in depressed patients.MethodsThis observational study evaluated 27 Caucasian adult patients (F = 18, M = 9), satisfying DSM-IV criteria for Major Depressive, Bipolar Disorder or Personality Disorder receiving treatment with Venlafaxine 75–300 mg/die.CYP2D6 alleles were evaluated with INFINITI CYP2D6 assay, which employs AutoGenomics proprietary film-based microarray technology.ResultsMost patients were identified as EMs, 4 as PMs, while only one was identified as UM. The only statistically significant difference between Extensive and Poor Metabolizers was, in contrast with current literature, the need of a greater mean dose of Venlafaxine in the second group (225 mg/die vs 159.38 mg/die, t student: p = 0.01).Likewise, in contrast with literature, the UM patient was responsive to average doses of Venlafaxine.On the contrary, we found no statistically significant differences as far as efficacy, adverse events or duration of treatment are concerned.ConclusionsIn our sample, CYP2D6 metabolizer status does not seem to affect treatment response nor adverse events related to Venlafaxine.
- Published
- 2011
11. P02-16 - E.R. Admissions of Immigrants Presenting with Psychiatric Symptoms: a Retrospective Study in Eastern Piedmont
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M. Probo, Eugenio Torre, L. Lavatelli, A. Parafioriti, M. Antona, Patrizia Zeppegno, and F. Ressico
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medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Immigration ,Retrospective cohort study ,medicine.disease ,Mental health ,Substance abuse ,Psychiatry and Mental health ,Psychiatric history ,Intervention (counseling) ,Culturally sensitive ,Marital status ,Medicine ,business ,Psychiatry ,media_common - Abstract
ObjectivesThe immigrant population in Italy is currently increasing, particularly, foreigners in East Piedmont raised by 16,8 % last year. We aim to compare immigrant and Italian patients’ Emergency Room (ER) admissions due to psychiatric symptoms.ResultsOf the 658 admissions we observed, 13.1 % of ER contacts concerned immigrants mostly coming from Russia, Albania, Morocco and Romania, consistently with migration streams in East Piedmont. Compared to the Italians, immigrant patients were younger (35.70; SD = 10.56 versus 44.78; SD = 16.57) and more frequently admitted for alcohol and substance abuse/withdrawal. Italians had a higher probability of having a psychiatric history including previous hospitalizations and contacts with Mental Health Services (OR = 2.60; CI 95 %: 1.64-4.12). The presence of social/relational problems associated with admission was significantly lower among the Italians (OR = 0.55; CI 95 %: 0.35-0.88).ConclusionsPreliminary data suggest that ER utilisation by immigrants may represent their main way to primary health care. Monitoring ER contacts may provide relevant information for the development of culturally sensitive Mental Health Services.MethodsWe considered Italian and immigrant patients with psychiatric symptoms who were admitted to the ER Department of Novara during a period of 13 months. We compared sociodemographic (gender, age, education, occupational history, marital status, living circumstances) clinical-anamnestic (history of psychiatric illness, presentation symptoms, previous contacts with Substance Abuse/Mental Health Services, social/relational problems) and admission (type of admission, intervention and discharge) characteristics of the two groups (Italians versus immigrants).
- Published
- 2010
12. P03-365 - Venlafaxine and CYP2D6 in Clinical Practice: Work in Progress
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Eugenio Torre, P. Prosperini, V. Dalò, Patrizia Zeppegno, F. Ressico, M. Vidali, Roberta Rolla, A. Parafioriti, and G. Bellomo
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CYP2D6 ,medicine.medical_specialty ,business.industry ,Adjustment disorders ,Venlafaxine ,medicine.disease ,Substance abuse ,Psychiatry and Mental health ,Concomitant ,Internal medicine ,medicine ,medicine.symptom ,Major depressive episode ,Psychiatry ,business ,Pharmacogenetic Test ,Pharmacogenetics ,medicine.drug - Abstract
ObjectiveVenlafaxine (V) is a SNRI metabolized primarily by the highly polymorphic cytochrome P4502D6 enzyme (CYP2D6) in O-desmethylvenlafaxine (ODV), the main active metabolite. Four CYP2D6 metabolizer phenotypes have been identified: poor (PM), intermediate (IM), extensive (EM) and ultrarapid (UM). Approximately 5-10% Caucasians are PMs; in these individuals metabolism of substrate is decreased and adverse clinical effects may be expected. The effectiveness of pharmacogenetic tests is controversial because the association between plasma levels of V/ODV and side effects is not attested.We discuss the association between CYP2D6-genotype and Venlafaxine clinical effects.MethodsWe will recruit Caucasian patients aged 18 to 65, eligible for Venlafaxine treatment, satisfying DSM-IV criteria for major depressive episode, dysthymia or depressive adjustment disorder. Exclusion criteria will be: pregnancy, acute suicidality, alcohol/substance abuse, concomitant/prior antidepressive treatment in the previous 3 months. We will assess patients’ age, gender, DSM-IV diagnosis, Venlafaxine dose, concomitant pharmacological treatment, BMI, BP, tobacco use, liver and kidney functionality. Clinical response and side effects will be monitored using CGI, HAM-D and SIDE at T0 (onset), T1 (1 week later) and T2 (6 weeks later).The patients will be analyzed for the presence of 16 CYP2D6-genotype variants by INFINITITTM CYP2D6 assay which utilizes AutoGenomics proprietary film-based microarray technology.ResultsWe expect to find out a correlation between CYP2D6-genotype, Venlafaxine dose and clinical response to treatment.ConclusionsWe will investigate whether a pharmacogenetic test prior to treatment can be useful in clinical practice to detect a proper Venlafaxine dosage or to switch to a different drug.
- Published
- 2010
13. Suicide attempts and emergency room psychiatric consultation
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Fabrizio Bert, Carla Gramaglia, Eugenio Torre, Roberta Siliquini, Luigi Mario Castello, I. Coppola, Gian Carlo Avanzi, Patrizia Zeppegno, F. Ressico, and Maria Rosaria Gualano
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Population ,Poison control ,Suicide, Attempted ,Psychiatric Department, Hospital ,Suicide prevention ,Occupational safety and health ,Risk Factors ,Injury prevention ,Psychiatric symptoms ,medicine ,Suicide attempt ,Humans ,Sex Distribution ,Psychiatry ,education ,Referral and Consultation ,education.field_of_study ,business.industry ,Public health ,Mental Disorders ,Human factors and ergonomics ,Emergency room ,Middle Aged ,Patient Acceptance of Health Care ,Hospitalization ,Psychiatry and Mental health ,Italy ,Socioeconomic Factors ,Multivariate Analysis ,Female ,Seasons ,business ,Emergency Service, Hospital ,Referral ,Research Article - Abstract
Background Suicidal behaviours are major public health concerns worldwide. They are associated with risk factors that vary with age and gender, occur in combination, and may change over time. The aim of our study was to investigate how frequently patients visiting a hospital emergency room (ER) require a psychiatric consultation for attempted suicide, and to outline the characteristics of this population. Methods Determinants of emergency room visits for psychiatric reasons were studied prospectively from 2008 to 2011 at the “Maggiore” Hospital in Novara. Results 280 out of 1888 patients requiring psychiatric consultation were referred to the ER because of suicide attempt. Suicide attempters were more often female. The rate of suicide attempters among Italian people was 14.2%, compared to 19.5% in foreigners. Subjects living with parents or own family and those having a permanent job had a higher frequency of suicide attempt. Suicide attempts were more frequent among patients with a history of psychiatric disorders; nonetheless, suicide attempts were more common among those who had not previously been hospitalized in a psychiatric ward or were not under the care of a psychiatrist. The multivariate analysis found that female gender was a risk factor for suicide attempt, while being in the colder months of the year and, surprisingly, unemployment were protective factors. Conclusions A better understanding of patients referring to the ER due to attempted suicide may allow the identification of at-risk subjects and the implementation of targeted treatment approaches.
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14. Synthesising 30 years of clinical experience and scientific insight on affective temperaments in psychiatric disorders: State of the art.
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Favaretto E, Bedani F, Brancati GE, De Berardis D, Giovannini S, Scarcella L, Martiadis V, Martini A, Pampaloni I, Perugi G, Pessina E, Raffone F, Ressico F, and Cattaneo CI
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- Humans, Mental Disorders psychology, Affect, Bipolar Disorder psychology, Temperament, Mood Disorders psychology
- Abstract
The concept of affective temperament has been extensively discussed throughout the history of psychopathology and represents a cornerstone in the study of mood disorders. This review aims to trace the evolution of the concept of affective temperaments (ATs) from Kraepelin's seminal work to the present day. In the 1980s, Akiskal redefined Kraepelin's concept of affective temperaments (ATs) by integrating the five recognized ATs into the broader framework of the soft bipolar spectrum. This conceptualization viewed ATs as non-pathological predispositions underlying psychiatric disorders, particularly mood disorders. Epidemiological and clinical studies have validated the existence of the five ATs. Furthermore, evidence suggests that ATs may serve as precursors to various psychiatric disorders and influence clinical dimensions such as disease course, psychopathology, and treatment adherence. Additionally, ATs appear to play a significant role in moderating phenomena such as suicide risk and stress coping. Incorporating an evaluation of temperamental bases of disorders into the multidimensional psychiatric diagnostic process could enhance treatment optimization and prognosis estimation., Competing Interests: Declaration of competing interest All authors declare no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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15. The shocking attitude toward electroconvulsive therapy in Italy.
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Cattaneo CI, Ressico F, Fornaro M, Fazzari G, and Perugi G
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- Attitude, Humans, Italy, Surveys and Questionnaires, Electroconvulsive Therapy
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- 2022
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16. Subduction hides high-pressure sources of energy that may feed the deep subsurface biosphere.
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Vitale Brovarone A, Sverjensky DA, Piccoli F, Ressico F, Giovannelli D, and Daniel I
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- Ammonia chemistry, Chemical Phenomena, Geological Phenomena, Hydrogen Sulfide chemistry, Mechanical Phenomena, Organic Chemistry Phenomena, Secologanin Tryptamine Alkaloids chemistry, Volcanic Eruptions, Ecosystem, Hydrogen chemistry, Methane chemistry, Minerals chemistry, Organic Chemicals chemistry, Thermodynamics
- Abstract
Geological sources of H
2 and abiotic CH4 have had a critical role in the evolution of our planet and the development of life and sustainability of the deep subsurface biosphere. Yet the origins of these sources are largely unconstrained. Hydration of mantle rocks, or serpentinization, is widely recognized to produce H2 and favour the abiotic genesis of CH4 in shallow settings. However, deeper sources of H2 and abiotic CH4 are missing from current models, which mainly invoke more oxidized fluids at convergent margins. Here we combine data from exhumed subduction zone high-pressure rocks and thermodynamic modelling to show that deep serpentinization (40-80 km) generates significant amounts of H2 and abiotic CH4 , as well as H2 S and NH3 . Our results suggest that subduction, worldwide, hosts large sources of deep H2 and abiotic CH4 , potentially providing energy to the overlying subsurface biosphere in the forearc regions of convergent margins.- Published
- 2020
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17. Sudden valproate-induced hyperammonemia managed with L-carnitine in a medically healthy bipolar patient: Essential review of the literature and case report.
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Cattaneo CI, Ressico F, Valsesia R, D'Innella P, Ballabio M, and Fornaro M
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- Adult, Humans, Hyperammonemia chemically induced, Male, Treatment Outcome, Antimanic Agents adverse effects, Bipolar Disorder drug therapy, Carnitine administration & dosage, Hyperammonemia drug therapy, Substance-Related Disorders drug therapy, Valproic Acid adverse effects
- Abstract
Rationale: Valproic Acid is a commonly used psychiatric drug primarily used as a mood stabilizer. Mild hyperammonemia is a Valproic Acid common adverse effect. This report presents an example of treated hyperammonemia on Valproic acid therapy managed with L-carnitine administration in BD patients characterized by sudden vulnerability., Patient Concerns: We report the case of a 29-year-old man suffering from bipolar disorder (BD) and substance use disorder who exhibited sudden altered mental status upon admittance to the inpatient unit. The patient was started on Valproic acid with no improvement., Diagnoses: The patient had remarkably high ammonia levels (594 μg/dL) without hepatic insufficiency, likely due to his valproate treatment., Interventions: The patient was administered lactulose, intravenous hydration, and i.v. levocarnitine supplementation 4.5 g/day., Outcomes: The administration leads to reduction of ammonia levels to 99 μg/dL within 12 hours upon initiation of carnitine therapy and progressive restore of his mental status within 24 hours., Lessons: Resolution of hyperammonemia caused by Valproic acid therapy may be enhanced with the administration of L-carnitine. An interesting aspect of this case was how rapidly the patient responded to the carnitine therapy.
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- 2017
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18. Alexithymia, empathy, emotion identification and social inference in anorexia nervosa: A case-control study.
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Gramaglia C, Ressico F, Gambaro E, Palazzolo A, Mazzarino M, Bert F, Siliquini R, and Zeppegno P
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- Adult, Affective Symptoms psychology, Anorexia Nervosa psychology, Awareness, Case-Control Studies, Female, Humans, Male, Middle Aged, Affective Symptoms complications, Anorexia Nervosa complications, Emotions, Empathy
- Abstract
Alexithymia, difficulties in facial emotion recognition, poor socio-relational skills are typical of anorexia nervosa (AN). We assessed patients with AN and healthy controls (HCs) with mixed stimuli: questionnaires (Toronto Alexithymia Scale-TAS, Interpersonal Reactivity Index-IRI), photographs (Facial Emotion Identification Test-FEIT) and dynamic images (The Awareness of Social Inference Test-TASIT). TAS and IRI Personal Distress (PD) were higher in AN than HCs. Few or no differences emerged at the FEIT and TASIT, respectively. Larger effect sizes were found for the TAS results. Despite higher levels of alexithymia, patients with AN seem to properly acknowledge others' emotions while being inhibited in the expression of their own., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
19. Suicide attempts and emergency room psychiatric consultation.
- Author
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Zeppegno P, Gramaglia C, Castello LM, Bert F, Gualano MR, Ressico F, Coppola I, Avanzi GC, Siliquini R, and Torre E
- Subjects
- Adult, Female, Hospitalization statistics & numerical data, Humans, Italy epidemiology, Male, Mental Disorders epidemiology, Mental Disorders psychology, Mental Disorders therapy, Middle Aged, Multivariate Analysis, Referral and Consultation statistics & numerical data, Risk Factors, Seasons, Sex Distribution, Socioeconomic Factors, Suicide, Attempted psychology, Time Factors, Emergency Service, Hospital statistics & numerical data, Patient Acceptance of Health Care statistics & numerical data, Psychiatric Department, Hospital statistics & numerical data, Suicide, Attempted statistics & numerical data
- Abstract
Background: Suicidal behaviours are major public health concerns worldwide. They are associated with risk factors that vary with age and gender, occur in combination, and may change over time. The aim of our study was to investigate how frequently patients visiting a hospital emergency room (ER) require a psychiatric consultation for attempted suicide, and to outline the characteristics of this population., Methods: Determinants of emergency room visits for psychiatric reasons were studied prospectively from 2008 to 2011 at the "Maggiore" Hospital in Novara., Results: 280 out of 1888 patients requiring psychiatric consultation were referred to the ER because of suicide attempt. Suicide attempters were more often female. The rate of suicide attempters among Italian people was 14.2%, compared to 19.5% in foreigners. Subjects living with parents or own family and those having a permanent job had a higher frequency of suicide attempt. Suicide attempts were more frequent among patients with a history of psychiatric disorders; nonetheless, suicide attempts were more common among those who had not previously been hospitalized in a psychiatric ward or were not under the care of a psychiatrist. The multivariate analysis found that female gender was a risk factor for suicide attempt, while being in the colder months of the year and, surprisingly, unemployment were protective factors., Conclusions: A better understanding of patients referring to the ER due to attempted suicide may allow the identification of at-risk subjects and the implementation of targeted treatment approaches.
- Published
- 2015
- Full Text
- View/download PDF
20. Early onset frontotemporal dementia with psychiatric presentation due to the C9ORF72 hexanucleotide repeat expansion: a case report.
- Author
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Gramaglia C, Cantello R, Terazzi E, Carecchio M, D'Alfonso S, Chieppa N, Ressico F, Rizza MC, and Zeppegno P
- Subjects
- C9orf72 Protein, Female, Frontotemporal Dementia genetics, Humans, Magnetic Resonance Imaging methods, Middle Aged, Mutation, Positron-Emission Tomography methods, DNA Repeat Expansion, Frontotemporal Dementia diagnosis, Proteins genetics
- Abstract
Background: Frontotemporal dementia (FTD) may present with psychiatric symptoms, usually together with neurological ones and in cases with a family history of dementia. We describe the case of an FTD behavioural variant with a psychiatric presentation and a normal neurological examination, due to a C9Orf72 gene mutation., Case Presentation: The patient was a 57 years-old Caucasian woman with a recent onset of bizarre behaviours and mystic delusions. She had a negative clinical history for previous psychiatric disorders and treatments and this was her first admission to a Psychiatry Ward. A careful assessment was performed including, beyond psychiatric evaluation, the following: blood sampling, neurological examination (including electroencephalogram, electroencephalogram with zygomatic electrodes, Positron Emission Tomography, Cerebrospinal Fluid Analysis), carotid artery Doppler ultrasound, brain Magnetic Resonance Imaging - angio Magnetic Resonance Imaging. Blood sampling for the genetic assessment of mutations associated to primary dementias was performed as well: the genes investigated were FUS, C9Orf72, PSEN-1, PSEN-2., Conclusions: Serological tests were negative, neurological examination was normal, instrumental examinations showed theta waves in the posterior temporal areas bilaterally and frontotemporal cortical atrophy bilaterally. The genetic assessment of mutations associated revealed she carried a GGGGCC hexanucleotide repeat expansion (at least 80 repeats) in C9Orf72 intron 1. Patients carrying the C9Orf72 mutation are likely to receive a psychiatric diagnosis (mainly mood disorder or schizophrenia) prior to correct diagnosis; this may be particularly problematic for those patients with no neurological signs to orientate diagnosis. Understanding the manner in which such FTD variant may present as a psychiatric syndrome, with a negative neurological examination, is essential to provide the best treatment for patients, as soon as possible, especially when the behavioural anomalies interfere with their care.
- Published
- 2014
- Full Text
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21. An observational study of Venlafaxine and CYP2D6 in clinical practice.
- Author
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Rolla R, Gramaglia C, Dalò V, Ressico F, Prosperini P, Vidali M, Meola S, Pollarolo P, Bellomo G, Torre E, and Zeppegno P
- Subjects
- Adult, Aged, Depressive Disorder, Major drug therapy, Depressive Disorder, Major genetics, Female, Humans, Male, Middle Aged, Phenotype, Venlafaxine Hydrochloride, Cyclohexanols therapeutic use, Cytochrome P-450 CYP2D6 genetics, Practice Patterns, Physicians'
- Abstract
Background: Venlafaxine (V) is a serotonin-norepinephrine selective reuptake inhibitor, mainly metabolized by cytochrome P4502D6 (CYP2D6). CYP2D6 polymorphisms result in a variety of phenotypes: poor (PMs), intermediate (IMs), extensive (EMs), and ultrarapid metabolizers (UMs). PMs usually show poor tolerance to drugs metabolized by CYP2D6, while UMs need greater doses. The aim of this study was to evaluate the impact of CYP2D6 genotype on V dosage, therapeutic response, and side effects in a clinical outpatient setting., Methods: 47 patients with Major Depressive Disorder, treated with V 75 - 300 mg/day, underwent CYP2D6 genotyping using the INFINITI-CYP2D6 assay. Duration of treatment and clinical outcome (Clinical Global Impression [CGI] effectiveness index) were assessed., Results: CGI assessment was performed after 6 weeks, 6 months, and 1 year of treatment with a V median dose of 150 mg/day. CYP2D6 genotyping resulted in 1 PM, 3 IMs, 42 EMs, and 1 UM. The UM took the greatest V dose (375 mg) without side effects; IMs/PMs took moderate/high doses of V (150 - 300 mg) without adverse effects; EMs displayed high response variability., Conclusions: PM/IM patients responded to V differently than expected according to genotype. However, the UM patient responded to a dosage higher than the usual therapeutic range and without developing side effects, suggesting an association between CYP2D6 gene duplication and the therapeutic efficacy of venlafaxine. The CYP2D6 genotyping may thus provide clinicians with a potential explanation for those patients requiring greater doses of CYP2D6 substrates in order to obtain the same therapeutic efficacy.
- Published
- 2014
- Full Text
- View/download PDF
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