232 results on '"F. O’Kelly"'
Search Results
2. Adapting lean methodology towards surgical tray rationalisation in inguinoscrotal day case surgery in the republic of Ireland
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E. Herlihy, B. Antao, A. Fawaz, J. McDermott, K. Patterson, G. Nason, and F. O'Kelly
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Urology ,Pediatrics, Perinatology and Child Health - Published
- 2023
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3. Comparison of open and robotic-assisted laparoscopic ureteral reimplantation in children with high grade (IV-V) vesicoureteral reflux: A multi-institutional comparative study
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S. Sforza, B.B. Marco, B. Haid, N. Baydilli, I. Donmez, A.F. Spinoit, I. Paraboschi, L. Masieri, L. Luksteinkellner, Y.I. Comez, R.J.M. Lammers, L.A. ‘t Hoen, F. O’kelly, E. Bindi, Y. Kibar, and M.S. Silay
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Urology - Published
- 2023
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4. Primary proximal hypospadias repair in in toilet-trained males is associated with a higher risk of post-operative complications and parental dissatisfaction
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F. O’Kelly, L.T. ’T Hoen, A.S. Spinoit, R.L. Lammers, B. Haid, B.B.M. Banuelos Marco, S.S. Sforza, E.B. Bindi, M.I.D. Donmez, N.B. Baydilli, and M.S. Silay
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Urology - Published
- 2023
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5. A systematic review of genitourinary injuries arising from rugby and football
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Min Joon Lee, Martin A. Koyle, Jin K. Kim, Lily Yuxi Ren, Gregory J. Nason, and F. O'Kelly
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Adult ,medicine.medical_specialty ,Urology ,Football ,030232 urology & nephrology ,Poison control ,Suicide prevention ,Occupational safety and health ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,030225 pediatrics ,Injury prevention ,medicine ,Humans ,Child ,business.industry ,Genitourinary system ,Incidence ,Incidence (epidemiology) ,Human factors and ergonomics ,Athletes ,Athletic Injuries ,Pediatrics, Perinatology and Child Health ,Emergency medicine ,business - Abstract
Summary Background Genitourinary injuries in athletes engaging in high-impact sports such as football and rugby may have catastrophic consequences, especially in individuals with pre-existing urologic concerns, such as a solitary kidney. Objective To summarize the current literature on football-related or rugby-related genitourinary organ injuries in both adult and pediatric populations in an effort to risk stratify the likelihood of these injuries. Methods An independent systematic literature search for records reporting football-related or rugby-related injuries was conducted by a certified librarian and reviewer in March 2019. The search electronic databases included Medline, EMBASE, Scopus, and Web of Science. All studies reporting football-related or rugby-related genitourinary injuries were included. Results Twenty-two records (11 research studies, 11 case reports) were identified. In the pediatric population, the reported football-related kidney injuries were 0.1–0.7% of all football-related injuries, 0.07–0.5% of all sports-related injuries, and 1.5–37.5% of all sports-related genitourinary injuries, with incidence ranging from 0.00000084 to 0.0000092 injuries per exposure (five studies). Pediatric football-related testicular injuries were reported to be 0.11% of all football injuries, 0–0.07% of all sports-related injuries, and 0–37.5% of all sports-related genitourinary injuries; injury per exposure was 0.0000092 (four studies). In adults, there was no proportion of genitourinary injuries that could be determined, and football-related kidney injury incidence was 0.000012 injuries per exposure (one study). No adult literature investigated testicular injuries. Eleven case reports were additionally identified. Review of the case reports suggests that patients with previously existing urologic abnormalities such as ureteropelvic junction obstruction may predispose an individual to kidney injuries. Conclusion There is little to suggest that those engaged in football or rugby have a significant risk of genitourinary injury; therefore, future guidelines should reflect this.
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- 2020
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6. Assessing the methodological and reporting quality of clinical systematic reviews and meta-analyses in paediatric urology: can practices on contemporary highest levels of evidence be built?
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I. Aditya, F. O'Kelly, Martin A. Koyle, Keara DeCotiis, and Luis H. Braga
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Research Report ,medicine.medical_specialty ,Download ,Urologists ,Urology ,media_common.quotation_subject ,030232 urology & nephrology ,Paediatric urology ,03 medical and health sciences ,0302 clinical medicine ,Meta-Analysis as Topic ,030225 pediatrics ,medicine ,Humans ,Quality (business) ,Child ,media_common ,Impact factor ,business.industry ,Evidence-based medicine ,Checklist ,Systematic review ,Family medicine ,Meta-analysis ,Pediatrics, Perinatology and Child Health ,Linear Models ,Construct (philosophy) ,business ,Systematic Reviews as Topic - Abstract
Summary Introduction Systematic reviews and meta-analyses provide a comprehensive summary of research studies and are used to assess clinical evidence, form policy and construct guidelines. This is pertinent to childhood surgery with issues of consent and condition prevalence. The aims of this study were to evaluate the methodological and reporting quality of these reviews and to identify how these reviews might guide clinical practice amongst those conditions most commonly encountered and managed by practicing paediatric urologists. Methods A systematic search of the English literature was performed to identify systematic reviews and meta-analyses focusing on clinical paediatric urology (1/1/1992-1/12/2018) to include common paediatric urological conditions managed by paediatric urology residents/fellows. To these reviews, Assessing the Methodological Quality of Systematic Reviews (AMSTAR)-2 and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) scores were applied. Univariate linear regression and descriptive statistical methods were performed. Results From an initial literature review of 1723 articles, 227 were included in the analysis. Inter-reviewer agreement was high amongst 3 independent reviewers (κ = 0.92). Eighty-four percent of systematic reviews and meta-analyses were published since 2009 following publication of the PRISMA guidelines. The overall impact factor was 3.38 (0.83–17.58), with adherence to AMSTAR-2 criteria 48.46% and PRISMA criteria 70.1%. From a methodological perspective, 15% of reviews were of moderate quality, 65% were of low quality and 20% reviews were of critically low quality, with none found to have good quality reporting. Conclusions Despite the continued increase of systematic reviews and meta-analyses in paediatric urology from which many guidelines are based, a significant number of reviews contain poor methodology and, to a lesser extent, poor reporting quality. Journals should consider having specific ‘a priori’ criteria based on checklists before publication of manuscripts to ensure the highest possible reporting quality. Download : Download high-res image (66KB) Download : Download full-size image Summary Figure . Methodological quality of existing paediatric urology peer-reviewed literature based on average AMSTAR-2 ratings of manuscripts
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- 2020
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7. External validation of a low fidelity dry-lab platform to enhance loupes surgical skills techniques for hypospadias repair
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V.P. Bhatia, J. Wolf, W.A. Farhat, B. Lewis, D.R. Gralnek, K.W. Eliceiri, and F. O'Kelly
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Urology ,Pediatrics, Perinatology and Child Health - Abstract
Hypospadias repair is an index pediatric urology procedure that requires trainee familiarity with surgical loupes. A previous low-fidelity, 6-step curriculum was proposed that deconstructed the most important steps of loupe surgery. We expanded on this curriculum with an intermediate-fidelity silicone hypospadias model and designed an abbreviated version of the 6-step curriculum to precede the hypospadias repair simulation.To assess the validity of our prior, low-fidelity conceptual model using the metric of improved performance on the intermediate-fidelity silicone hypospadias model.A silicone model was first prototyped with the design software Solidworks™, and then fabricated using a cast made of a mixture of silicone rubbers designed to function like skin and soft tissue (Mold Star 20T, Dragon skin FX-pro and Slacker). Casts were used to create the penile shaft model and the dorsal hooded foreskin model. The urethral plate was cast separately on a flat surface. The model was then assembled by hand. The model used for simulation included the penile shaft and urethral plate, while the dorsal-hooded foreskin was prepared to simulate the penile anatomy separately. Trainees were then divided into two groups. Group 1 practiced the low-fidelity curriculum (3 tasks) and then performed dissection of the urethral plate and suturing using the intermediate-fidelity hypospadias model. Group 2 practiced hypospadias repair prior to the low-fidelity curriculum. Both groups' models were scored by 3 blinded urologists. Trainees were then asked to complete a post simulation satisfaction survey. Data analysis was performed in IBM SPSS Statistics for Macintosh (Version 28.0 Armonk, NY: IBM Corp).Twenty-two candidates across Wisconsin, USA, and Dublin, Ireland participated in the study. This included 7 s-year residents, 9 third-year residents, 2 fourth-year residents, and 3 fifth-year residents. Both Groups 1 and 2 had a similar distribution of trainees (p = 0.60). Group 1 outperformed group 2 in all tasks (p 0.05, Table 1). Trainees reported that the platform was very useful (91%).Our curriculum showed improvement in trainee ability and comfort to perform hypospadias repair. Advantages of such a simulated curriculum include improving current resident training in microsurgery, improving surgical ergonomics for trainees prior to real-time experience, and decreasing the learning curve for trainees pursuing pediatric urology.An intermediate-fidelity hypospadias platform externally validates the conceptual model implemented in the low-fidelity loupes curriculum. This appears to lead to improvement in loupe surgical skills regardless of trainee level.
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- 2022
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8. Has urological run-through training had an impact on specialist trainee presentation and subsequent publication rates in peer-reviewed journals?
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C. O’Connell, G.J. Nason, and F. O’Kelly
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Urology - Published
- 2022
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9. Bringing Jewish Ritual circumcision (Brit Milah) Into the Operating Room: An Analysis of Surgical Outcomes and Satisfaction Across Families and Society of Pediatric Urology members
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Alexander B. Koven, David E. Levin, Ezriel Reichman, Jacob C. Langer, F. O'Kelly, Ali El-Ghazzaoui, Martin A. Koyle, Yisroel Goldstein, and Aubie Diamond
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Male ,medicine.medical_specialty ,Operating Rooms ,Attitude of Health Personnel ,Judaism ,Urology ,030232 urology & nephrology ,MEDLINE ,Personal Satisfaction ,Pediatrics ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Practice Patterns, Physicians' ,Ceremonial Behavior ,Societies, Medical ,Retrospective Studies ,Response rate (survey) ,business.industry ,Ritual circumcision ,Infant ,Perioperative ,Pediatric urology ,United States ,Caregiver satisfaction ,Circumcision, Male ,030220 oncology & carcinogenesis ,Family medicine ,Case-Control Studies ,Jews ,business ,Cultural competence - Abstract
Objective To assess caregiver satisfaction, procedural outcomes and practitioner opinion regarding a novel program designed for patients to undergo a deferred Jewish ritual circumcision (Brit Milah) in the operating room (OR), combined with other indicated surgical procedures. Methods All patients undergoing Brit Milah in the OR at our institution between 2013 and 2019 were included. Surveys were administered to assess caregiver satisfaction and Society for Pediatric Urology member practice patterns. A retrospective case-control series was completed to compare complication rates and operative times for procedures with and without Brit Milah. Results Forty-four intraoperative Brit Milah patients were identified. The mean procedure time for a distal hypospadias repair with Brit Milah was 66.0 minutes, compared to 62.4 minutes without (P = .57). No complications were attributable to the addition of Brit Milah. The caregiver survey had a 100% response rate. The modal response for satisfaction with the perioperative experience was 5 of 5 (ie, highly satisfied), with 100% of respondents very likely to recommend the program. 132 active Society for Pediatric Urology members responded to the survey (34.1% response rate) with 44% regularly allowing Brit Milah in the OR at their institution. 90.5% received positive caregiver feedback and 64% believe it is important to offer. Conclusion This novel program incorporating Brit Milah into the OR yields high caregiver satisfaction, no additional OR time or postoperative complications, and provides an opportunity to combine family-centered care with cultural competence.
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- 2020
10. Structured opioid-free protocol following outpatient hypospadias repair - A prospective SQUIRE 2.0-compliant quality improvement initiative
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Karen Milford, C. McDonnell, Martin A. Koyle, Martha Pokarowski, F. O'Kelly, and Keara DeCotiis
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Adult ,Male ,medicine.medical_specialty ,Quality management ,Urology ,Population ,030232 urology & nephrology ,Run chart ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Outpatients ,Medicine ,Humans ,Prospective Studies ,Medical prescription ,Practice Patterns, Physicians' ,Prospective cohort study ,education ,Child ,education.field_of_study ,Hypospadias ,Pain, Postoperative ,business.industry ,Infant ,medicine.disease ,Quality Improvement ,Analgesics, Opioid ,Telephone interview ,Opioid ,Pediatrics, Perinatology and Child Health ,Emergency medicine ,business ,medicine.drug - Abstract
Summary Background Prescription opioids have been extensively to manage postoperative pain in children. A growing body of evidence from the adult literature, suggests however, that healthcare providers may be prescribing far more opioids than required, with some studies demonstrating equivalent post-operative pain and clinical outcomes with their omission. Objective The objectives of this prospective study were to assess the current heterogeneity of practice in post-operative opioids prescription following day case hypospadias surgery, to establish a streamlined discharge protocol, and to reduce the use of post-operative opioid prescription by 30% within a 4 month period through the use of systemic forcing functions and education. Study design This prospective study was approved by the Quality Improvement (QI) sub-committee of the hospital's Research and Ethics Board (REB) and was compliant with the Standards for Quality Improvement Reporting Excellence (SQUIRE 2.0) guidelines. Recruited parents (n = 84) were contacted for telephone interview following a combined intervention of education and omission of post-operative opioids from the discharge prescription. A mixture of qualitative and quantitative techniques were employed including an initial process analysis to assess current opioid use, the creation of balancing measures, and the creation of Plan-Do-Study–Act cycles. Age, procedure, post-operative outcomes and opioid prescription data were recorded over a period of 6 months in 2019. Results Initial measures in our process analysis demonstrated significant institutional practice variation amongst our 84 post-intervention patients. Our process and fidelity measures confirmed 100% information provision. Following the point of intervention, there was a significant and sustained drop in opioid prescription, with an absolute reduction of 35%, and a relative reduction of 56%. There was no significant difference in patient age, pain scores, or outcomes pre- and post-intervention. Discussion We have shown in this study that a sustainable decrease in post-operative opioid prescriptions following hypospadias surgery is possible. We managed to achieve a relative reduction 56% which is comparable to other specialties, however, did it within a quality improvement framework to ensure fidelity and no adverse balancing measures. We also managed to reduce the number of doses prescribed in those receiving opioids post-intervention at week 9. Conclusion Our study demonstrates opioids can be safely omitted in hypospadias cohorts without any adverse clinical outcomes or balancing measures. We recommend that opioids be used extremely judiciously in this population in order to minimize exposure in children. Download : Download high-res image (162KB) Download : Download full-size image Summary Figure . Trends in opioid prescription and balancing measures pre- and post-implementation of a quality improvement program for opioids reduction with outpatient hypospadias repairs (ER: Emergency room).
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- 2020
11. A cross-sectional needs assessment and attitudes survey of paediatric urologists towards gaps and areas of perceived importance in adolescent transitional care
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F. O'Kelly, R. Subramaniam, B. Haid, A. Bujons, B. Burgu, A-F. Spinoit, R. Nijman, C. Radmayr, and M.S. Silay
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Urology - Published
- 2022
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12. Pathways and perceived barriers to paediatric urology subspecialisation: A study of incumbent attitudes and opinions
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F. O'Kelly, L. T' Hoen, B. Banuelos, R. Lammers, A. Radford, S. Sforza, M. Hiess, E. Bindi, A-F. Spinoit, M.S. Silay, and B. Haid
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Urology - Published
- 2022
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13. The hidden workload and cost of a rapid access prostate cancer clinic: Patients with no prostate cancer
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Dilly M. Little, F O’Kelly, Richard E. Power, GM Smyth, I Cheema, MP Broe, and M Matanhelia
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Oncology ,medicine.medical_specialty ,business.industry ,Urology ,Workload ,medicine.disease ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Rapid access ,Surgery ,030212 general & internal medicine ,business - Published
- 2018
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14. Newsworthiness vs scientific impact: are the most highly cited urology papers the most widely disseminated in the media?
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Stacy Loeb, Rustom P. Manecksha, Eabhann M. O'Connor, F. O’Kelly, and Gregory J. Nason
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medicine.medical_specialty ,business.industry ,Urology ,030232 urology & nephrology ,Scientific literature ,Evidence-based medicine ,Positive correlation ,Digital media ,03 medical and health sciences ,0302 clinical medicine ,Ranking ,Bibliometrics ,Citation analysis ,030220 oncology & carcinogenesis ,medicine ,Humans ,Social media ,Altmetrics ,Journal Impact Factor ,business - Abstract
Background Discordance exists between scientific impact and media attention. Altmetrics are non-traditional measures of impact which are composite scores that include social media and traditional media sharing of an article. Objective To assess whether a correlation exists between newsworthiness (Altmetric score) and the scientific impact markers such as citation analysis, impact factors and levels of evidence. Materials and Methods The top 5 most cited articles for the year 2014 and 2015 from the top 10 ranking urology journals (scientific impact group) were identified. The top 50 articles each in 2014 and 2015 were identified from Altmetric support based on media activity (media impact group). We determined the number of citations that these articles received in the scientific literature, and calculated correlations between citations with Altmetric scores. Results In the scientific impact group, the mean number of citations per article was 37.6, and the most highly cited articles were oncology guidelines. The mean Altmetric score in these articles was 14.8, There was a weak positive correlation between citations and Altmetric score (rs = 0.35, 95% CI 0.16-0.52, p
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- 2017
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15. Antibiotic resistance patterns of Escherichia coli urinary isolates and comparison with antibiotic consumption data over 10 years, 2005–2014
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P J Stapleton, Margaret M. Hannan, N Scanlon, R McWade, F. O’Kelly, Dara Lundon, and Maureen Lynch
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0301 basic medicine ,medicine.medical_specialty ,Time Factors ,medicine.drug_class ,030106 microbiology ,Antibiotics ,History, 21st Century ,Microbiology ,03 medical and health sciences ,Antibiotic resistance ,Internal medicine ,Escherichia coli ,medicine ,Humans ,Antimicrobial stewardship ,Escherichia coli Infections ,Retrospective Studies ,business.industry ,Drug Resistance, Microbial ,General Medicine ,bacterial infections and mycoses ,Trimethoprim ,Anti-Bacterial Agents ,Ciprofloxacin ,Nitrofurantoin ,Urinary Tract Infections ,Female ,Gentamicin ,business ,Empiric therapy ,medicine.drug - Abstract
Escherichia coli is a common cause of urinary tract infections (UTI). Reviews of antibiotic resistance of this organism can inform choice of empiric treatment of UTI and other infections and strategies for combating antimicrobial resistance. We reviewed laboratory and hospital pharmacy records to assess trends in non-susceptibility rates and the effect of antimicrobial stewardship interventions. A retrospective observational study of isolates of E. coli from MSU samples at a Dublin teaching hospital from inpatients and community, obtained from January 2005 to December 2014. Susceptibility to a panel of antibiotics was determined using the disc diffusion method, as well as extended-spectrum beta-lactamase (ESBL) production status. Trends in resistance were plotted graphically and analysed in a descriptive manner. Except for nitrofurantoin and gentamicin, non-susceptibility increased for all antimicrobials tested. Co-amoxiclav non-susceptibility reached 48% in hospital and 32.6% in the community by 2014. Piperacillin–tazobactam non-susceptibility increased from 6.8 to 23.8% in hospital and from
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- 2017
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16. Recruitment of New Consultants
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G J, Nason, F, O’Kelly, M F, Daly, and M K, O’Reilly
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Consultants ,Education, Medical, Graduate ,Humans ,Medicine ,Personnel Selection ,Ireland ,Specialization - Published
- 2019
17. Predictive value of PI-RADS classification in MRI-directed transrectal ultrasound guided prostate biopsy
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Lisa P. Lavelle, E. NiMhurchu, D. Mulvin, F. O'Kelly, G. Lennon, Colm J. McMahon, D. Galvin, Ian G. Murphy, Conor D. Collins, and D.M. Quinlan
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Male ,medicine.medical_specialty ,Prostate biopsy ,Biopsy ,030218 nuclear medicine & medical imaging ,Cohort Studies ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Predictive Value of Tests ,Prostate ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ultrasonography, Interventional ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Prostatic Neoplasms ,Reproducibility of Results ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Ultrasound-Guided Prostate Biopsy ,PI-RADS ,Radiology Information Systems ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Predictive value of tests ,Radiology ,business - Abstract
Aim To correlate the results of transrectal ultrasound (TRUS)-guided targeted prostate biopsies (performed in the setting of at least one previous negative biopsy) with the Prostate Imaging Reporting and Data System (PI-RADS). Material and methods Fifty-two patients (mean age 64 years, range 52–76 years), with previous negative prostate biopsy underwent magnetic resonance imaging (MRI)-directed TRUS-guided targeted and sectoral biopsy. A retrospective review of MRI examinations was carried out, blinded to biopsy results. PI-RADS scores (T2, diffusion-weighted imaging [DWI] and overall) were assigned on a per lesion basis, and localised to sextants. The scores were correlated with biopsy results, and the positive predictive values (PPV) of PIRADS scores for positive biopsies were calculated. Results Overall, biopsies were positive in 23/52 (44.2%) patients. Eighty-one areas were targeted in 52 patients. On a per lesion basis, there was significant correlation between positive targeted biopsy and both T2 and overall PI-RADS score (p
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- 2016
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18. Response to Editorial commentary: predatory publishing or a lack of peer-review transparency?-a contemporary analysis of indexed open and non-open access articles in pediatric urology
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F O'Kelly and M A Koyle
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Publishing ,business.industry ,Urology ,Internet privacy ,MEDLINE ,Paediatric urology ,Transparency (behavior) ,Predatory publishing ,Pediatrics, Perinatology and Child Health ,Medicine ,Humans ,business ,Child - Published
- 2018
19. Extramammary Paget ’s disease Of Glans Penis: A Rare Case Report
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M S, Inder, F, O’Kelly, M, Sheikh, K, O’Hare, M L, Barbara, and J A, Thornhill
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We present the case of an 83-year-old man with Extramammary Paget’s disease (EMPD) of the penis. He underwent a total penectomy and histopathology confirms the association of underlying invasive high grade urothelial carcinoma. Penile EMPD is rare and can be misinterpreted for benign skin conditions. A high index of suspicion is required for correct diagnosis and appropriate treatment.
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- 2018
20. Predatory publishing or a lack of peer review transparency?-a contemporary analysis of indexed open and non-open access articles in paediatric urology
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Martin A. Koyle, Nicolás Fernández, and F. O'Kelly
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Publishing ,medicine.medical_specialty ,Impact factor ,business.industry ,Abstracting and Indexing ,Urology ,030232 urology & nephrology ,MEDLINE ,Transparency (behavior) ,Pediatrics ,Access to Information ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Family medicine ,Pediatrics, Perinatology and Child Health ,Medicine ,Periodicals as Topic ,business ,Citation ,Publication ,Open access journal - Abstract
Summary Introduction The advent of open access publishing has allowed for unrestricted and rapid knowledge dissemination and can generate higher citation levels. However, the establishment of predatory journals exploits this model and may lead to publication of non-peer reviewed work. Objective The objective of this study was to compare the characteristics and trends of indexed publications in paediatric urology. The primary outcomes were to compare open access vs non-open access publishing. The secondary outcome was to assess whether any open access publications in this cohort could be classified as predatory based on journal data basing and external peer review policies. Methods PubMed, MEDLINE and Embase reviews were carried out for any publication using the terms ‘p(a)ediatric urology’ over a 5-year period (October 2012–2017). These publications were individually accessed, assessed for relevance and cross-checked using the ISI Web of Knowledge Journal Citation Report. Bibliometric data, journal type and access model were all individually assessed, ranked and compared using descriptive and non-parametric statistical methods. Results From an initial total of 4075 indexed publications, 2244 journal publications across 51 countries were included based on relevance, of which 611 were open access. Open access journals were significantly more likely to publish basic science/laboratory versus clinical publications (10.9% vs 3.3%). They were more likely have higher average citations/publication (17 vs. 8), but there was no difference between open and closed journal impact factors (3.1 vs. 2.7). The overall rate of open access, indexed publications that were not peer reviewed and/or included in open access databases was 6.5% Discussion The overall numbers of paediatric urological articles appearing on PubMed between 2012 and 2017 have increased by approximately 75%, while the number of open access articles has remained relatively static (25%). Researchers may prefer to publish in specific journals to disseminate results to a particular audience or fear in the current climate that an open access journal may not be considered legitimate, and possibly even predatory, thus having a negative impact on the data and the author's reputation. The impact factor status and route/method of publication may be less important. Conclusions Open access, peer reviewed publishing allows rapid international knowledge dissemination. The exact objective definition of what constitutes a predatory journal remains controversial. We have identified a time-stable prevalence of 6.5% open access publications that could meet proposed criteria for a ‘borderline/predatory journal’; however, this should not influence the decision to publish in open access journals. Summary Table . Top 10 journals publishing paediatric urological articles 2012–2017 Impact factor Eigen factor Journal name Open access option (yes/no) Included publications, 2012–2017 1.611 0.00443 Journal of Paediatric Urology Yes 581 2.309 0.02603 Urology Yes 292 5.157 0.05533 Journal of Urology Yes 242 1.082 0.0038 Canadian Urological Association Journal Yes 62 1.976 0.01754 Journal of Pediatric Surgery Yes 58 2.27 0.00987 Journal of Endourology Yes 38 1.739 0.00656 International Urology & Nephrology Yes 29 2.124 0.00269 Current Urology Reports Yes 26 2.172 0.00209 Frontiers in Pediatrics Yes 23 1.844 0.00602 International Journal of Urology Yes 21
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- 2018
21. Twitter expands the reach and engagement of a national scientific meeting: the Irish Society of Urology
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Gregory J. Nason, D. Bouchier-Hayes, F. O’Kelly, Rustom P. Manecksha, and David M. Quinlan
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Internet ,medicine.medical_specialty ,Blogging ,Information Dissemination ,business.industry ,Communication ,Interprofessional Relations ,Urology ,General Medicine ,Congresses as Topic ,Research Personnel ,language.human_language ,Irish ,Analytics ,Physicians ,language ,Humans ,Medicine ,Social media ,business ,Cyberspace ,Ireland ,Social Media ,Healthcare analytics - Abstract
Social media is the interaction among people in which they create, share or exchange information and ideas in virtual communities and web-based networks. This year, the Irish Society of Urology (ISU) expanded its involvement in social media with a preregistered Twitter hashtag (#ISU14) for the annual meeting. The aim of this study was to highlight the use of Twitter at an annual national meeting held in 2014. The Symplur healthcare analytics website was used to prospectively examine traffic related to the 2014 ISU Annual Meeting. This feature was used to generate statistics for the number of impressions, unique tweets (excluding retweets) and distinct contributors who used the indexing hashtag #ISU14. Individual tweets were assessed using the conference hashtag on the Twitter website. The total number of attendees at the conference was 119, and 99 individuals participated in Twitter using the conference hashtag (#ISU14). 31 % of attendees participated in tweeting at the conference. Over the course of the conference, a total of 798 unique tweets were generated, creating over 665,000 impressions in cyberspace. 590 (73.9 %) tweets were generated from attendees at the conference, while 26.1 % of tweets were from virtual followers. 702 (87.9 %) tweets were from urologists and 439 (55 %) tweets were of scientific nature. Tweet activity peaked during the guest lectures on both days. Twitter use at the ISU has been shown to facilitate interaction between delegates and allows users to follow as well as participate from afar.
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- 2015
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22. Conversion rates of abstracts to publications from the Irish Society of Urology Annual Meeting (2005–2011) – Questioning the scientific value of national urological meetings for smaller European nations
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Louise C. McLoughlin, GJ Nason, A Galbraith, DM Quinlan, S Bell, F. O’Kelly, and JA Thornhill
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medicine.medical_specialty ,Impact factor ,business.industry ,Urology ,MEDLINE ,Publication bias ,language.human_language ,Irish ,Value (economics) ,medicine ,language ,Surgery ,business - Abstract
Background: Large annual scientific meetings such as the American Urological Association (AUA) and the European Association of Urology (EUA) have abstract conversion rates into publication of 37%−48%. There are no data on the conversion rates from national meetings of smaller European countries. Our objective was to present the conversion rates and manuscript characteristics of the Irish Society of Urology (ISU) annual meeting over a seven-year period (2005–2011), and to demonstrate the value, viability and sustainability of such a meeting as a model for other small national research programmes. Methods: All abstracts presented at the ISU annual meeting between 2005 and 2011 were identified. The subsequent publication rate following the meetings was established for the corresponding studies based on a Medline scan. A range of characteristics associated with subsequent publication were analysed using the logistic regression of the dichotomous variable of publications vs. non-publication of each factor. Results: Overall, 46% of the 322 abstracts presented at the ISU meeting were followed by publication into Medline-indexed journals with a mean impact factor of 2.6. A total of 74% abstracts were published within two years. Oral presentations were more likely to be published than posters ( p < 0.0001), and prospective clinical research was more likely to be published in a journal with a higher impact factor than retrospective analyses ( p = 0.033); the mean time to publication was 16.7 months. Conclusions: Almost half the abstracts presented at the ISU were subsequently published in peer-reviewed journals, the majority within two years. This compares favourably with larger urological meetings, and provides an incentive to other smaller countries within Europe to continue with national research programmes.
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- 2015
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23. The emerging use of Twitter by urological journals
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Michael E. Kelly, Rustom P. Manecksha, Nigel Phelan, F. O’Kelly, Declan G. Murphy, Gregory J. Nason, and Nathan Lawrentschuk
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Impact factor ,business.industry ,Urology ,Medicine ,Social media ,business ,Citation ,Demography - Abstract
Objective To assess the emerging use of Twitter by urological journals. Methods A search of the Journal of Citation Reports 2012 was performed to identify urological journals. These journals were then searched on Twitter.com. Each journal website was accessed for links to social media (SoMe). The number of ‘tweets’, followers and age of profile was determined. To evaluate the content, over a 6-month period (November 2013 to April 2014), all tweets were scrutinised on the journals Twitter profiles. To assess SoMe influence, the Klout score of each journal was also calculated. Results In all, 33 urological journals were identified. Eight (24.2%) had Twitter profiles. The mean (range) number of tweets and followers was 557 (19–1809) and 1845 (82–3692), respectively. The mean (range) age of the twitter profiles was 952 (314–1758) days with an average 0.88 tweets/day. A Twitter profile was associated with a higher mean impact factor of the journal (mean [sd] 3.588 [3.05] vs 1.78 [0.99], P = 0.013). Over a 6-month period, November 2013 to April 2014, the median (range) number of tweets per profile was 82 (2–415) and the median (range) number of articles linked to tweets was 73 (0–336). Of these 710 articles, 152 were Level 1 evidence-based articles, 101 Level 2, 278 Level 3 and 179 Level 4. The median (range) Klout score was 47 (19–58). The Klout scores of major journals did not exactly mirror their impact factors. Conclusion SoMe is increasingly becoming an adjunct to traditional teaching methods, due to its convenient and user-friendly platform. Recently, many of the leading urological journals have used Twitter to highlight significant articles of interest to readers.
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- 2014
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24. Is citation index a good indicator of landmark papers in urology?
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F. O’Kelly, John A. Thornhill, and Louise C. McLoughlin
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Syllabus ,medicine.medical_specialty ,Landmark ,business.industry ,Urology ,Citation index ,medicine ,Surgery ,Citation ,business - Abstract
Objective: Knowledge of landmark papers in urology is essential both for the practise of evidence-based medicine and for trainees requiring a syllabus for the FRCS Urology examination. Citation index (CI) is seen as a direct measure of the quality of a scientific paper. The aim of this study was to compare papers with the highest CI in each urologic sub-speciality with the landmark papers in urology. Methods: Seventy-nine of the highest impact factor journals in urology, medicine and urologic sub-specialities were identified from the Journal of Citation Reports: Science edition 2012. Urology papers with the highest CI were identified from these journals using the database of the Science CI (1965–2012). Forty-four landmark papers in urology were then identified from textbooks, recommended reading lists for the FRCS Urology examination, and publications on landmark urology papers. High CI papers were then compared to landmark papers. Results: The top 10 cited papers in each urologic sub-speciality were identified. A total of 31.8% ( n = 14) landmark papers were among the top 10 cited papers. Urinary tract infection had the highest proportion of landmark papers in the top 10 cited articles. Kidney cancer papers had the highest mean CI while urinary tract trauma had the lowest. Conclusion: This study shows that CI alone is a poor indicator of landmark papers in urology. This paper gives a comprehensive overview both of landmark papers in urology and those with the highest CI, and may be used as an adjunct to the FRCS Urology syllabus.
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- 2014
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25. Paediatric orchidopexy: a need for dedicated paediatric surgical training among urologists?
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C. M. Akram, Michael E. Kelly, A. Aslam, Subhasis K. Giri, F. O’Kelly, Hugh D. Flood, M. J. Burke, and Gregory J. Nason
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Male ,Gynecology ,medicine.medical_specialty ,Paediatric surgery ,Attitude of Health Personnel ,business.industry ,Urology ,General surgery ,Age Factors ,Infant ,Mean age ,General Medicine ,Paediatric surgeon ,urologic and male genital diseases ,Pediatrics ,Surgical training ,Increased risk ,Orchiopexy ,Cryptorchidism ,medicine ,Humans ,Testicular tumours ,Stage (cooking) ,business ,Ireland - Abstract
Undescended testis (UDT) is one of the most common congenital abnormalities with a prevalence of about 1 % at the age of 1 year. UDT is associated with an increased risk of testicular tumours and infertility. The aim of this study was to assess who is carrying out paediatric orchidopexy in Ireland. A survey was distributed via Survey Monkey® to all Consultant Paediatric Surgeons and Urologists in Ireland. Twenty-seven (64.3 %) urologists and five (71.4 %) paediatric surgeons responded to our online survey. Of the urologists, 100 % reported formal training in paediatric orchidopexy. Eight (29.6 %) underwent a dedicated paediatric fellowship. 13 (48.1 %) currently perform paediatric orchidopexy. Nine (33 %) think it should be carried out by a urologist, whereas eight (29.6 %) think it should be carried out by paediatric surgeon. The mean age at which urologists think an orchidopexy for UDT should be performed by was 18 months (range 1–4 years). Approximately 400 orchidopexies are performed per year by the surveyed urologists. Of the paediatric surgeons, three (60 %) feel it should be carried out by a paediatric surgeon whereas two (40 %) feel it does not matter. All paediatric surgeons feel it should be performed by 1 year of age. Approximately 700 orchidopexies are performed per year by the surveyed paediatric surgeons. UDT is a concerning condition which requires intervention at an early stage. Dedicated training in core paediatric procedures is required to continue to meet this need for the future to prevent delayed orchidopexy and resultant increased risk of testicular tumours.
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- 2014
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26. The clinic-pathological characteristics of prostate cancer in an Irish subpopulation with a serum PSA less than 4.0ng/ml
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BB McGuire, Robert Flynn, Ted McDermott, Ronald Grainger, John A. Thornhill, and F. O’Kelly
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medicine.medical_specialty ,Prostatectomy ,business.industry ,Urology ,medicine.medical_treatment ,urologic and male genital diseases ,medicine.disease ,Prostate cancer ,Prostate-specific antigen ,medicine.anatomical_structure ,Prostate ,Cohort ,medicine ,Biomarker (medicine) ,Surgery ,Family history ,business ,Radical retropubic prostatectomy - Abstract
Background: Prostate specific antigen (PSA) has been used as a biomarker for prostate cancer for the last 20 years. Traditionally, a serum PSA Methods: A retrospective analysis was performed of all patients who underwent radical retropubic prostatectomy (RRP) in a tertiary referral unit over a 10-year period (2000–2010). Clinico-pathological characteristics were collated including those from trans-rectal ultrasound-guided (TRUS) prostate biopsies and radical prostatectomy specimens. Results: Between 2000 and 2010, 651 men underwent an RRP, with 43 (6.6%) having a serum PSA Conclusions: A PSA cut-off of 4 ng/ml has commonly been used in the detection of prostate cancer. Our study emphasizes that this cut-off is inappropriate and that no specific level of PSA can be used. Management decisions need to be individualized based on index of suspicion with concomitant counselling and rectal examination.
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- 2014
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27. Trends and attitudes towards paediatric circumcision in the South of Ireland
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Claire Brady, S. Elamin, F. O’Kelly, E. A. Kiely, and D. M. Fanning
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Attitude of Health Personnel ,Service delivery framework ,MEDLINE ,Surveys and Questionnaires ,Humans ,Medicine ,Child ,Physician's Role ,Response rate (survey) ,Potential impact ,business.industry ,Significant difference ,Infant, Newborn ,Infant ,Questionnaire ,General Medicine ,Middle Aged ,Surgical procedures ,Circumcision, Male ,Child, Preschool ,General Surgery ,Family medicine ,Female ,business ,Ireland ,Paediatric population - Abstract
Paediatric circumcision is one of the oldest surgical procedures performed worldwide. Traditionally performed by general surgeons, paediatric surgeons and urologists, there is a falling trend in the rate of paediatric circumcision being performed by adult and paediatric general surgeons. There is currently no corresponding contemporary data pertaining to trends and attitudes of general surgeons to paediatric circumcision in Ireland. The aim of this study was to assess the trends and attitudes of consultant general surgeons, and to assess its potential impact on the specialist delivery of paediatric urological care. A questionnaire was mailed to all practicing general surgeons in whom we identified as having a potential role in the management of paediatric circumcision. Data pertaining to population demographics within the south of Ireland were accessed through the Central Statistics Office. There was an 89 % response rate to the questionnaire survey. Seventy-seven percent of those under 50 were trained in adult circumcision compared with 100 % of those respondents over 50 years. There was a significant difference in paediatric circumcision with only 24 % those under 50 performing this procedure compared with 68 % above 50 years. Eighty-six percent respondents under 45 years (35 % over 45 years) felt that this procedure should be carried out by urology. In a region with an expanding paediatric population, it is crucial to maintain paediatric urological services. Given present trends and attitudes of newer appointed general surgeons, it is essential that further specialist appointments are made, and funding directed towards demand in order to keep pace.
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- 2014
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28. Predatory Publishing in Pediatric Urology
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F. O’Kelly and M.A. Koyle
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Publishing ,medicine.medical_specialty ,business.industry ,Urology ,030230 surgery ,Pediatric urology ,03 medical and health sciences ,0302 clinical medicine ,Predatory publishing ,Family medicine ,medicine ,Humans ,030212 general & internal medicine ,Child ,business - Published
- 2018
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29. Zero Ischemia Laparoscopic Partial Thulium Laser Nephrectomy
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Arun Z. Thomas, F. O’Kelly, Derek Hennessey, L.G. Smyth, Thomas H. Lynch, and Diarmaid Moran
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Adult ,Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Operative Time ,Renal function ,Kidney ,Nephrectomy ,chemistry.chemical_compound ,Ischemia ,Occlusion ,medicine ,Humans ,Prospective Studies ,Carcinoma, Renal Cell ,Aged ,Creatinine ,Warm Ischemia Time ,business.industry ,Perioperative ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,Surgery ,chemistry ,Hemostasis ,Female ,Laparoscopy ,Laser Therapy ,Tomography, X-Ray Computed ,business ,Follow-Up Studies ,Glomerular Filtration Rate ,Kidney disease - Abstract
Laser technology presents a promising alternative to achieve tumor excision and renal hemostasis with or without hilar occlusion, yet its use in partial nephrectomy has not been significantly evaluated. We prospectively evaluated the thulium:yttrium-aluminum-garnet laser in laparoscopic partial nephrectomy (LPN) in our institution over a 1-year period.We used the thulium laser with a wavelength of 2013 nm in the infrared spectrum. Data were recorded prospectively. Tumor size, preoperative aspects and dimensions used for an anatomical classification (PADUA) score, operative time, warm ischemia time (WIT), and perioperative and postoperative morbidity were recorded. Blood loss, preoperative and postoperative creatinine level, and estimated glomerular filtration rate (eGFR) were also collected.A total of 15 patients underwent consecutive LPN. The mean tumour diameter was 2.85 (1.5-4). The mean PADUA score was 6.8 (6-9). The mean total operative time was 168 minutes (128-306 min). Mean blood loss was 341 mL (0-800 mL). Date of discharge was 3.2 days postoperatively (2-8 days). The renal vessels were not clamped, resulting in a WIT of 0 minutes in all cases. There was no statistical significant increase in serum creatinine level or decrease in eGFR postoperatively. Histologically, the majority of lesions (13/15 patients) were renal-cell carcinoma stage pT1a. In all cases, base margins had negative results for tumor.The 2013-nm thulium laser system offers excellent hemostasis and precise resection capability of the renal cortex during LPN of small partially exophytic renal tumors. Our series showed excellent perioperative functional and pathologic outcomes, including minimal blood loss, zero ischemia, negative tumor margins, and preservation of renal function.
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- 2013
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30. Characteristics of modern Gleason 9/10 prostate adenocarcinoma: a single tertiary centre experience within the Republic of Ireland
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P. J. Kelly, M. F. O’brien, A. Brady, F. O’Kelly, S. Elamin, P. Aherne, J. White, A. Cahill, K. N. O’Regan, Nick Mayer, P. Sweeney, J. Buckley, and D. G. Power
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Male ,Biochemical recurrence ,medicine.medical_specialty ,Biopsy ,Urology ,Population ,Perineural invasion ,Adenocarcinoma ,urologic and male genital diseases ,Tertiary Care Centers ,Prostate cancer ,Prostate ,medicine ,Humans ,Neoplasm Metastasis ,education ,Aged ,Retrospective Studies ,Gynecology ,education.field_of_study ,Neoplasm Grading ,business.industry ,Incidence ,General surgery ,Prostatic Neoplasms ,Retrospective cohort study ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Cohort ,business ,Ireland - Abstract
The 2005 international society of urological pathology consensus statement on Gleason grading in prostate cancer revised Gleason scoring in clinical practice. The potential for grade migration with this refinement poses difficulties in interpreting historical series. We report the characteristics of a recent cohort of consecutive Gleason score 9 or 10 prostate cancers in our institution. The purpose of this study was to define the clinicopathologic variables and staging information for this high-risk population, and to identify whether traditional prostate staging techniques are adequate for this subcohort of men.A computational review of our pathology database was performed. Between May 2010 and September 2012, 1,295 consecutive biopsies were undertaken, 168 of which were high-grade tumours (12.97 %). This group were divided into two cohorts of which 84 (12.05 %) had a highest reported Gleason score of 9 (N = 79) or 10 (N = 5) and 84 were reported as Gleason 8. All biopsies were double-reported by pathologists with a special interest in uropathology.Men diagnosed with a Gleason pattern 5 tumour were statistically far more likely to have advanced disease on direct rectal examination of the prostate compared with Gleason sum 8 tumours (p0.001) and a positive first-degree family history of prostate cancer (p0.001). Overall, Gleason sum 9/10 prostate cancers were also found to be statistically more aggressive than Gleason sum 8 tumours on TRUS core biopsy analysis with significantly higher levels of perineural invasion (p0.0001) and extracapsular extension (p = 0.001) as well as a higher levels of tumour found within the core biopsy sample. Those men diagnosed with Gleason pattern 5 prostate cancer also had radiological indicators of increased tumour aggressiveness compared with Gleason sum 8 cancer with respect to bone (p = 0.0002) and visceral (p = 0.044) metastases at presentation.This series of Gleason score 9/10 prostate cancers serves to highlight the large disease burden, adverse pathologic features, and locally advanced nature of this aggressive subtype, which has previously been under-described in the literature, and differs from historical series in having a large high-grade cohort demonstrating high rates of metastatic disease. A history of prostate cancer amongst first-degree relatives was particularly prevalent in this population raising the issue of screening in a high-risk population. The high incidence of visceral metastatic disease at presentation supports upfront staging with CT thorax, abdomen, and pelvis in patients with Gleason 9 or 10 prostate cancers.
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- 2013
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31. Can delayed time to referral to a tertiary level urologist with an abnormal PSA level affect subsequent gleason grade in the opportunistically screened population?
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Arun Thomas, David Mulvin, David M. Quinlan, Denise Murray, F. O’Kelly, and D. Galvin
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PSA Velocity ,medicine.medical_specialty ,education.field_of_study ,medicine.diagnostic_test ,Referral ,business.industry ,Prostatectomy ,Urology ,medicine.medical_treatment ,Population ,Physical examination ,urologic and male genital diseases ,medicine.disease ,Asymptomatic ,Prostate cancer ,medicine.anatomical_structure ,Oncology ,Prostate ,Medicine ,medicine.symptom ,business ,education - Abstract
PURPOSE There is growing conflict in the literature describing the effect of delayed treatment on outcomes following radical prostatectomy. There is also evidence to suggest progression of low-risk prostate cancer to develop higher grades and volumes of prostate cancer during active surveillance. It is unknown as to what affect a delay in referral of those men with abnormal screened-PSA levels have on subsequent Gleason grade. METHODS We identified 350 men through our rapid access prostate clinic who underwent TRUS biopsy for abnormal age-related PSA and/or abnormal clinical examination. Clinicopathological findings were compared for those with positive versus negative TRUS biopsies, and for those with initial delays in referral ( 18 months). We used ANOVA and Student's t-tests amongst other statistical tools to examine significance of clinical findings. RESULTS Of the 350 men who underwent TRUS biopsy, those with a delay in referral of 12 months or more were significantly associated with higher PSA titers, clinically palpable disease and likelihood of diagnosis with prostate cancer. A delay of 18 months or more led to a significantly higher risk of being diagnosed with a leading grade 4 prostate cancer, which was further supported using PSA velocity as a diagnostic tool (change >0.4 ng/ml/year). CONCLUSION We recommend that repeated asymptomatic abnormal age-related PSA readings and/or abnormal clinical examination in the screened population be referred without delay to a urologist for further assessment, enrolment into an active surveillance program or definitive subsequent treatment. Prostate 73:1263–1269, 2013. © 2013 Wiley Periodicals, Inc.
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- 2013
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32. Emerging evidence for Gleason grade migration and distance impact in prostate cancer? An analysis of the rapid access prostate clinic in a tertiary referral center: St. Vincent’s University Hospital, Dublin (2009–2011)
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David Mulvin, H. Forristal, D. Murray, David M. Quinlan, Patrick Nicholson, F. O’Kelly, N. Swan, R. F. O’Carroll, P. Lee, D. Galvin, and A. Z. Thomas
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Adult ,Male ,medicine.medical_specialty ,Referral ,Gleason grade ,Health Services Accessibility ,Hospitals, University ,Tertiary Care Centers ,Prostate cancer ,Prostate ,medicine ,Rapid access ,Humans ,Prospective Studies ,Prospective cohort study ,Referral and Consultation ,Aged ,Gynecology ,business.industry ,General surgery ,Prostatic Neoplasms ,General Medicine ,Middle Aged ,University hospital ,medicine.disease ,Treatment Outcome ,ComputingMethodologies_PATTERNRECOGNITION ,medicine.anatomical_structure ,Referral center ,Neoplasm Grading ,business ,Ireland - Abstract
Recent evidence has suggested that the introduction of rapid access prostate cancer programs has led to a more streamlined pathway for patients, and was designed to ultimately reduce referral delays.To identify the initial impact of the introduction of the rapid access prostate clinic on Gleason grading within the prostate cancer cohort, as well as the impact of distance from a tertiary referral center on subsequent Gleason grading.A prospective database was maintained from those men attended the rapid access prostate clinic in St. Vincent's University Hospital. Data relating to demographics, biopsy results, retrospective PSA readings, and subsequent treatment pathways were all recorded and analyzed. Statistical significance was taken at p0.05.Prospective data from the rapid access prostate clinic illustrated similar results in patient demographics, Gleason grade and choice of treatment outcomes to other published institutions, however, for the first time demonstrate emerging evidence of the effect of the rapid access prostate clinic leading to a downward shift in Gleason grade over a 2-year period, as well as data showing an inverse correlation between leading Gleason grade and distance from our tertiary referral center.These results suggest that the introduction of the rapid access prostate clinic has initially begun to demonstrate an initial downgrading in Gleason scoring patterns. Our data also reflects a poorer Gleason score in those patients living further away from the rapid access prostate clinic. This may be in part attributed to a surge in referrals of those patients previously managed outside a tertiary institution, and suggests that patients should undergo prompt referral following suspicion for prostate cancer.
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- 2013
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33. A novel case of laparoscopic ureterolithotomy in a partial duplex ureteric collecting system: can open procedures still be justified in the minimally invasive era?
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A. Carroll, Stephen J. Skehan, J. Brennan, David Mulvin, F. O’Kelly, and Patrick Nicholson
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medicine.medical_specialty ,Ureteral Calculi ,business.industry ,fungi ,food and beverages ,General Medicine ,Middle Aged ,Collection system ,Duplex Kidney ,Surgery ,Duplex (building) ,medicine ,Humans ,Female ,Laparoscopy ,Stents ,Ureter ,business ,Escherichia coli Infections ,Laparoscopic ureterolithotomy ,Nephrostomy, Percutaneous ,Ureteral Obstruction - Abstract
Impacted ureteric stones can pose a treatment challenge due to the high level of failure of ESWL and endourological approaches. Laparoscopic ureterolithotomy can provide a safe and successful alternative to these and open, invasive procedures.Interval laparoscopic ureterolithtomy was carried out following placement of a percutaneous nephrostomy. This was performed through an trans-peritoneal approach with the ureterotomy closed by intracorporeal suturing and placement of a JJ stent without the need for an abdominal wound drain.Laparoscopic ureterolithotomy is a safe, minimally invasive method of managing large, impacted ureteric stones with minimal associated patient morbidity.
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- 2013
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34. The need for a post-operative thromboembolic event registry? A five-year retrospective tertiary institution study of venothromboembolic events within 30 days of major urological surgery
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F O’Kelly, D. B. Hennessey, AZ Thomas, R Grainger, IM Cullen, LG Smyth, T.E.D. McDermott, B Walsh, and TH Lynch
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medicine.medical_specialty ,business.industry ,Urology ,medicine ,Tertiary institution ,Surgery ,Post operative ,business ,Urological surgery ,Event (probability theory) ,Pelvic surgery - Abstract
Background: Recent evidence has suggested that the use of extended (≤ 28 ± seven days) post-operative low-molecular-weight heparin (LMWH) therapy following major abdominal/pelvic surgery can significantly reduce the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE). However, there is still significant discordance as to optimal LMWH duration among general and urological surgeons. There is marked variation over prescribing practices within urological surgery, and prospective studies have not reached a consensus. We aimed to determine if there was a significant prevalence of symptomatic thromboembolic events post-major urological surgery. Materials and methods: A five-year retrospective audit of major urological cases undertaken in our institution sought to examine the number of vascular complications encountered within 30 ± seven days of surgery by patients on standard thromboprophylactic therapy. Results: A total of 439 major surgical cases were carried out, of which 79% were oncological. Ninety-three per cent of patients had at least one cardiovascular disease risk factor. There was one post-operative clinically evident DVT (0.22%) and no PEs in this cohort. Conclusion: Our results suggest that symptomatic thromboembolic events post-major urological surgery may be infrequent. However, there is the need for a comprehensive multi-centre prospective study to examine for thromboembolic events post-discharge. As such, we must recommend careful patient selection in determining who would benefit from extended thromboprophylaxis.
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- 2013
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35. A Prospective Study of Total Glans Resurfacing for Localized Penile Cancer to Maximize Oncologic and Functional Outcomes in a Tertiary Referral Network
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Gregory J. Nason, Paul Sweeney, Ivor M. Cullen, Paul K. Hegarty, F. O’Kelly, Dara Lundon, and Peter E. Lonergan
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Male ,medicine.medical_specialty ,Visual Analog Scale ,Visual analogue scale ,Urology ,Penile Neoplasm ,030232 urology & nephrology ,Tertiary Care Centers ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,medicine ,Penile cancer ,Humans ,Prospective Studies ,Glans ,Prospective cohort study ,Penile Neoplasms ,Referral and Consultation ,Aged ,business.industry ,Cosmesis ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Surgery ,Survival Rate ,medicine.anatomical_structure ,Treatment Outcome ,Patient Satisfaction ,030220 oncology & carcinogenesis ,Neoplasm Recurrence, Local ,Sexual function ,business ,Follow-Up Studies ,Penis - Abstract
Penile cancer is a rare malignancy worldwide, representing only 1% of all cancers affecting men. There are little data outlining the comparative effectiveness of penile preservation techniques and to our knowledge no guidelines regarding their use currently exist. Outcomes data reporting is nonstandardized and followup is not measured consistently. The aim of this study was to analyze the outcomes of total glans resurfacing in terms of oncologic control, form and function in localized penile cancer.From 2013 to 2015, 19 prospectively enrolled patients underwent total glans resurfacing. Demographics, cosmesis, patient satisfaction and disease recurrence were assessed at followup to quantify oncologic and functional outcomes. At 3 months of followup patients completed the IIEF (International Index of Erectile Function) questionnaire detailing erectile and sexual function, and general satisfaction using a visual analog scale. All statistical analysis was performed with Prism® 6.No perioperative complications were experienced. Of the patients 94.7% had complete graft take with a median cosmesis score of 5 of 5 on the visual analog scale. There was 1 local and no regional nodal recurrence at a mean followup of 23 months. One-year progression-free and overall survival rates were 100% and the 1-year recurrence-free survival rate was 95%. Of the patients 81% reported an improved sex life postoperatively.Total glans resurfacing is a viable and acceptable option for glans preservation in patients with localized penile cancer. It demonstrates acceptable functional and oncologic outcomes. We believe that total glans resurfacing should be considered in all cases of localized penile cancer.
- Published
- 2016
36. Dynamic sentinel node biopsy for penile cancer: an initial experience in an Irish Hospital
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Martin O'Connell, F. O’Kelly, A Nic An Riogh, Peter E. Lonergan, D O'Sullivan, Paul K. Hegarty, and Dara Lundon
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Population ,030232 urology & nephrology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Penile Carcinoma ,medicine ,Penile cancer ,Humans ,education ,Lymph node ,Penile Neoplasms ,Aged ,education.field_of_study ,Groin ,business.industry ,Sentinel Lymph Node Biopsy ,General Medicine ,Sentinel node ,Middle Aged ,medicine.disease ,Hospitals ,Dissection ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Radiology ,business ,Ireland ,Gamma probe - Abstract
The presence of nodal metastases is the single most important prognostic factor in penile cancer. However, reliable assessment of nodal status in clinically node-negative (cN0) patients poses a challenge. Approximately 20% of these patients harbour occult nodal metastases. Currently available non-invasive radiological investigations are unreliable in excluding micrometastatic disease. Dynamic sentinel node biopsy (DSNB) is a minimally invasive procedure for assessing lymph node involvement. We report our initial experience with DSNB in assessing the status of regional lymph nodes in cN0 penile cancer patients. DSNB was performed in penile cancer patients with at least one cN0 groin. All patients undergoing DSNB at our institution were included. Lymphoscintigraphic images were obtained from all patients, after intradermal, peritumoral injection of a Technetium-99m nanocolloid. The sentinel nodes were defined as the nodes identified on lymphoscintigraphy, which were also radioactive intraoperatively using a gamma probe. In total, 18 groins from 11 patients underwent DSNB. Of these, 11 patients underwent bilateral DSNB and 4 had unilateral DSNB. The mean (range) age of patients at the time of presentation of their primary tumour was 63 (39–78) years. A mean of 1.2 nodes per groin was retrieved. One lymph node was positive in one patient, who subsequently underwent a bilateral inguinal lymph node dissection. Overall, the median (range) follow-up was 12.8 (2.7–31.3) months with no local or regional recurrences. Further cases and longer follow-up will define the accuracy of this technique in the Irish population.
- Published
- 2016
37. Characteristics of gram-negative urinary tract infections caused by extended spectrum beta lactamases: pivmecillinam as a treatment option within South Dublin, Ireland
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Siobhan Kavanagh, Jérôme P. Fennell, John A. Thornhill, Rustom P. Manecksha, and F. O’Kelly
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0301 basic medicine ,Male ,Veterinary medicine ,Antibiotic resistance ,General Practice ,Pilot Projects ,chemistry.chemical_compound ,0302 clinical medicine ,Medical microbiology ,Risk Factors ,Prevalence ,030212 general & internal medicine ,Prospective Studies ,Escherichia coli Infections ,Urinary tract infection ,Mean inhibitory concentration ,Hospitals ,Anti-Bacterial Agents ,Hospitalization ,Klebsiella pneumoniae ,Infectious Diseases ,Cohort ,Urinary Tract Infections ,Female ,medicine.drug ,Research Article ,medicine.medical_specialty ,Urinary system ,030106 microbiology ,Microbial Sensitivity Tests ,Amoxicillin-Potassium Clavulanate Combination ,Pivmecillinam ,beta-Lactamases ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Minimum inhibitory concentration ,Internal medicine ,Drug Resistance, Bacterial ,Gram-Negative Bacteria ,medicine ,Escherichia coli ,Humans ,lcsh:RC109-216 ,Extended-spectrum beta lactamase ,Mecillinam ,Aged ,business.industry ,Amdinocillin ,Amdinocillin Pivoxil ,Klebsiella Infections ,Nursing Homes ,Parasitology ,chemistry ,business ,Gram-Negative Bacterial Infections ,Ireland - Abstract
Background The prevalence of urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae is increasing and the therapeutic options are limited, especially in primary care. Recent indications have suggested pivmecillinam to be a suitable option. This pilot study aimed to assess the viability of pivmecillinam as a therapeutic option in a Dublin cohort of mixed community and healthcare origin . Methods A prospective measurement of mean and fractional inhibitory concentrations of antibiotic use in 95 patients diagnosed with UTI caused by ESBL-producing Enterobacteriaceae was carried out. 36 % patients were from general practice, 40 % were admitted to hospital within south Dublin, and 25 % samples arose from nursing homes. EUCAST breakpoints were used to determine if an isolate was sensitive or resistant to antibiotic agents. Results Sixty-nine percent of patients (N = 66) with urinary ESBL isolates were female. The mean age of females was 66 years compared with a mean age of 74 years for males. Thirty-six percent of isolates originated from primary care, hospital inpatients (26 %), and nursing homes (24 %). The vast majority of ESBL isolates were E. coli (80 %). The E tests for mecillinam and co-amoxiclav had concentration ranges from 0.16 mg/L up to 256 mg/L. The mean inhibitory concentration (MIC) of mecillinam ranged from 0.25 to 256 mg/L, while co-amoxiclav MICs ranged from 6 to 256 mg/L. The percentage of isolates resistant to mecillinam and co-amoxiclav was found to be 5.26 and 94.74 % respectively. Conclusions This is the first study exploring the use of pivmecillinam in an Irish cohort and has demonstrated that its use in conjunction with or without co-amoxiclav is an appropriate and useful treatment for urinary tract infections caused by ESBL-producing organisms.
- Published
- 2016
38. Patient reported functional outcomes following robotic-assisted (RARP), laparoscopic (LRP), and open radical prostatectomies (ORP)
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G. P. Smyth, Su White, E. Dunne, Gregory J. Nason, F. O’Kelly, and Richard E. Power
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Male ,medicine.medical_specialty ,Robotic assisted ,medicine.medical_treatment ,030232 urology & nephrology ,Urology ,Urinary incontinence ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Robotic Surgical Procedures ,medicine ,Humans ,Patient Reported Outcome Measures ,Prospective Studies ,Aged ,Retrospective Studies ,Prostatectomy ,business.industry ,Prostatic Neoplasms ,General Medicine ,Middle Aged ,medicine.disease ,Urinary function ,Erectile dysfunction ,Treatment Outcome ,030220 oncology & carcinogenesis ,Cohort ,International Prostate Symptom Score ,medicine.symptom ,business - Abstract
Radical prostatectomy for prostate cancer is associated with significant complications, such as urinary incontinence and erectile dysfunction. Debate remains regarding the influence of surgical technique on these important functional outcomes.The aim of this study was to compare the early functional outcomes following robotic-assisted (RARP), laparoscopic (LRP), and open radical prostatectomy (ORP) in a rapid access cohort.A retrospective review of a prospectively maintained database was performed between 2011 and 2014. Functional status was objectively assessed using the International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF-5), and a self-reported continence score.Two hundred and ninety-two patients underwent RP (85 RARP, 100 LRP, 107 ORP). The mean age was 61.3 years with a mean initial PSA was 6.2 ng/ml. There was no difference noted in urinary function between ORP, LRP, and RARP at 3 months (p = 0.894), 6 months (p = 0.244), 9 months (p = 0.068) or 12 months (p = 0.154). All men noted a deterioration in erectile function; however, there was no difference at 3 months (p = 0.922), 6 months (p = 0.723), 9 months (p = 0.101) or 12 months (p = 0.395), CONCLUSION: Equivalent good early functional outcomes are being achieved in patients undergoing RP irrespective of surgical approach. Longer follow-up in a prospective randomized fashion is required to fully assess the most appropriate surgical technique.
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- 2016
39. Extramammary Paget’s Disease
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Dara Lundon, F. O’Kelly, and Paul K. Hegarty
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medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Apocrine ,Disease ,Malignancy ,medicine.disease ,Dermatology ,Extramammary Paget's disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Seborrheic dermatitis ,medicine ,Penile cancer ,Disease process ,business - Abstract
Extramammary Paget’s disease (EMPD) is a rare intraepithelial malignancy that has only been a few hundred times in the literature with level 4 evidence. The precise incidence is unknown. However, little is known regarding optimal treatment and prognostic factors. Due to poor understanding of the condition, it can remain undiagnosed for a number of years prior to treatment, and with individual patient numbers remaining small across centers, it becomes difficult to build up a true understanding of the disease process.
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- 2016
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40. An 11-year analysis of the prevalent uropathogens and the changing pattern of Escherichia coli antibiotic resistance in 38,530 community urinary tract infections, Dublin 1999–2009
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F. O’Kelly, Ivor M. Cullen, John A. Thornhill, Rustom P. Manecksha, R. Grainger, Philip Murphy, Eddie McCullagh, Sarfraz Ahmad, Jérôme P. Fennell, T.E.D. McDermott, and Robert Flynn
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,medicine.drug_class ,Antibiotics ,Microbial Sensitivity Tests ,Drug resistance ,Amoxicillin-Potassium Clavulanate Combination ,Trimethoprim ,Microbiology ,Antibiotic resistance ,Ciprofloxacin ,Internal medicine ,Ampicillin ,Drug Resistance, Bacterial ,Escherichia coli ,Prevalence ,medicine ,Humans ,Child ,Escherichia coli Infections ,Retrospective Studies ,Cefuroxime ,business.industry ,Incidence ,General Medicine ,Anti-Bacterial Agents ,Community-Acquired Infections ,Nitrofurantoin ,Urinary Tract Infections ,Female ,Gentamicin ,Gentamicins ,business ,medicine.drug - Abstract
Knowledge of local antimicrobial resistance patterns is essential for evidence-based empirical antibiotic prescribing, and a cutoff point of 20 % has been suggested as the level of resistance at which an agent should no longer be used empirically. We sought to identify the changing incidence of causative uropathogens over an 11-year period. We also examined the trends in antibiotic resistance encountered in both the pooled urine samples and those where the causative organism was Escherichia coli. A retrospective analysis of the antimicrobial resistance within the positive community urine isolates over the 11-year period, 1999 to 2009, in a single Dublin teaching hospital was performed. In total 38,530 positive urine samples processed at our laboratory originated in the community of which 23,838 (56.7 %) had E. coli as the infecting organism. The prevalence of E. coli has been increasing in recent years in community UTIs with 70.4 % of UTIs in the community caused by E.coli in 2009. Ampicillin and trimethoprim were the least-active agents against E. coli with mean 11-year resistance rates of 60.8 and 31.5 %, respectively. Significant trends of increasing resistance over the 11-year period were identified for trimethoprim, co-amoxyclav, cefuroxime and gentamicin. Ciprofloxacin remains a reasonable empirical antibiotic choice in this community with an 11-year resistance rate of 10.6 %. Higher antibiotic resistance rates were identified in the male population and in children. Resistance rates to commonly prescribed antibiotics are increasing significantly. This data will enable evidence-based empirical prescribing which will ensure more effective treatment and lessen the emergence of resistant uropathogens in the community.
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- 2012
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41. Survival after incidental prostate cancer diagnosis at transurethral resection of prostate: 10-year outcomes
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R. Grainger, Robert Flynn, Sarfraz Ahmad, F. O’Kelly, Rustom P. Manecksha, Ted McDermott, Ivor M. Cullen, and J. A. Thornhill
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Male ,Oncology ,medicine.medical_specialty ,Antineoplastic Agents, Hormonal ,medicine.medical_treatment ,Disease ,Resection ,Prostate cancer ,Prostate ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,Watchful Waiting ,Aged ,Aged, 80 and over ,Prostatectomy ,Incidental Findings ,Radiotherapy ,business.industry ,Prostatic Neoplasms ,General Medicine ,Middle Aged ,medicine.disease ,Survival Analysis ,medicine.anatomical_structure ,Cohort ,Hormone therapy ,business ,Prostatism ,Watchful waiting - Abstract
The most appropriate management of incidental prostate cancers diagnosed at transurethral resection of prostate has been debated. It is important to determine the long-term outcomes to establish an appropriate management in patients with incidental prostate cancer. We aim to determine 10-year survival and to identify the factors of worse prognosis of incidental prostate cancers diagnosed at transurethral resection of prostate. A retrospective analysis of patients with pT1a–pT1b prostate cancers diagnosed between 1998 and 2003. Medical notes, PSA and pathology results were reviewed. Overall and cancer specific survival was calculated at mean 10-year follow-up. Sixty patients with incidental prostate cancer were identified (pT1a = 18, pT1b = 42). Fifty-one percents of the patients were managed on a watchful waiting strategy with overall 84% survival and 9.7% cancer specific mortality. Twenty patients (all with pT1b) received hormone therapy. Overall survival in this cohort was 50% with 20% cancer specific mortality. Nine patients received curative therapy (Radical prostatectomy = 4, Radiotherapy = 5). In this group, overall survival was 88% with no cancer specific mortality. Stage pT1a disease and preoperative low PSA were associated with favourable survival. However, for pT1b and/or high Gleason score (≥7), mortality was comparatively higher. Hence, patients with high Gleason score and/or pT1b disease should be considered for curative therapy. Additionally, active surveillance may have a role in selected men with incidental prostate cancer.
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- 2011
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42. The changing pattern of antimicrobial resistance within 42 033 Escherichia coli isolates from nosocomial, community and urology patient-specific urinary tract infections, Dublin, 1999-2009
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Jérôme P. Fennell, John A. Thornhill, Rustom P. Manecksha, Ronald Grainger, Robert Flynn, F. O’Kelly, Eddie McCullagh, Ted McDermott, Ivor M. Cullen, Sarfraz Ahmad, and Philip Murphy
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education.field_of_study ,medicine.medical_specialty ,business.industry ,Urology ,Population ,Drug resistance ,bacterial infections and mycoses ,Trimethoprim ,Ciprofloxacin ,Antibiotic resistance ,Nitrofurantoin ,Ampicillin ,medicine ,Gentamicin ,education ,business ,medicine.drug - Abstract
Study Type – Therapy (practice patterns cohort) Level of Evidence not applicable What's known on the subject? and What does the study add? Epidemiological and resistance patterns of bacterial pathogens in urinary tract infections show large inter-regional variability, and rates of bacterial resistance are continually changing due to different regional antibiotic treatment regime. In Ireland and the UK, trimethoprim or nitrofurantoin is usually recommended for empirical treatment of uncomplicated cystitis in the community whilst parenteral cephalosporins, aminoglycosides, quinolones and co-amoxyclav are reserved for complicated UTIs. Neither penicillins nor trimethoprim represent suitable empirical antimicrobial agents for UTI in this study population. The high rate of ciprofloxacin resistance in encountered is suggestive of an over-reliance on this agent in this population and with resistance rates approaching 30%, empirical use of quinolones for urology patients is inadvisable. E. coli UTIs have remained extremely sensitive to nitrofurantoin across all three patient sample groups in this population and the resistance rate has not changed significantly over the eleven-year study period. OBJECTIVE • To investigate the changing pattern of antimicrobial resistance in Escherichia coli urinary tract infection over an eleven year period, and to determine whether E. coli antibiotic resistance rates vary depending on whether the UTI represents a nosocomial, community acquired or urology patient specific infection. PATIENT AND METHODS • A retrospective analysis of the 42 033 E. coli urine isolates from the 11-year period 1999–2009 in a single Dublin teaching hospital was performed. • WHONETTM software was used to analyse the changing pattern of sensitivity and resistance of E. coli to commonly used antibiotics over the study period. • The origins of the urine samples were stratified into three groups: inpatients with nosocomial UTIs; urine originating from the emergency department and general practice (community UTIs); and UTIs in urology patients. RESULTS • Urinary tract infections in the urology patient population demonstrate higher antibiotic resistance rates than nosocomial or community UTIs. • There were significant trends of increasing resistance over the 11-year period for ampicillin, trimethoprim, gentamicin and ciprofloxacin, and significant differences in co-amoxyclav, gentamicin, nitrofurantion and ciprofloxacin resistance rates depending on the sample origin. • Ampicillin and trimethoprim were the least active agents against E. coli, with total 11-year resistance rates of 58.3 and 33.8%, respectively. • The overall gentamicin resistance rate was 3.4% and is climbing at a rate of 0.7% per year (P < 0.001). Within the urology patient population the resistance rate was 6.4%. • Ciprofloxacin resistance approaches 20% in the nosocomial UTI population and approaches 30% in the urology population; however, it remains a reasonable empirical antibiotic choice in this community, with an 11-year resistance rate of 10.6%. CONCLUSIONS • E. coli remains the commonest infecting uropathogen in the community and hospital setting with its incidence climbing from 50 to 60% of UTIs over the 11-year period. • Neither penicillins nor trimethoprim represent suitable empirical antimicrobials for UTI and ciprofloxacin resistance in this Dublin-based study renders it unsuitable empirical therapy for nosocomial UTIs and UTIs in the urology population. • The dramatic 11-year rate increase in gentamicin resistance is of paramount concern.
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- 2011
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43. Electroejaculatory Stimulation and Its Implications for Male Infertility in Spinal Cord Injury: A Short History Through Four Decades of Sperm Retrieval (1975-2010)
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F. O’Kelly, Ted McDermott, Robert Flynn, Ivor M. Cullen, Ronald Grainger, and Rustom P. Manecksha
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Male ,Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,Stimulation ,History, 20th Century ,medicine.disease ,Male infertility ,Reproductive Techniques ,Text mining ,Reproductive Medicine ,Semen ,Sperm Retrieval ,Humans ,Lymph Node Excision ,Medicine ,Ejaculation ,business ,Spinal cord injury ,Infertility, Male ,Spinal Cord Injuries ,Retrospective Studies - Published
- 2011
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44. Triple-vessel mesenteric ischaemia presenting with gastric ulceration
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J. K. Loh, N. Keeling, F O'Kelly, Kheng Tian Lim, W. Shields, Narayanasamy Ravi, and John V. Reynolds
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Chronic mesenteric ischaemia ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Ischemia ,Refractory ,Angioplasty ,Humans ,Medicine ,Stomach Ulcer ,Vascular Diseases ,cardiovascular diseases ,business.industry ,Angiography ,Conventional treatment ,General Medicine ,Middle Aged ,medicine.disease ,digestive system diseases ,Surgery ,Mesenteric ischaemia ,Mesenteric Ischemia ,Female ,Stents ,Coeliac trunk ,business - Abstract
We present an unusual presentation of chronic mesenteric ischaemia in a patient with recurrent gastric ulceration that highlights both the importance of recognition of ischaemia as a possible aetiology in those refractory to conventional treatment and the success of percutaneous transluminal mesenteric angioplasty in these cases.
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- 2011
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45. Historical bibliometric analysis of the top cited articles on vesicoureteral reflux 1950–2016, and incorporation of a novel impact index
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Andrew J. Kirsch, Jessica H. Hannick, A. Azuero, Anthony A. Caldamone, A. Puerto, Mandy Rickard, Martin A. Koyle, F. O'Kelly, and Nicolás Fernández
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Publishing ,Vesico-Ureteral Reflux ,medicine.medical_specialty ,Time Factors ,Impact factor ,business.industry ,Download ,Urology ,030232 urology & nephrology ,MEDLINE ,Science Citation Index ,Bibliometrics ,Pediatric urology ,03 medical and health sciences ,0302 clinical medicine ,Index (publishing) ,Family medicine ,Pediatrics, Perinatology and Child Health ,Humans ,Medicine ,030212 general & internal medicine ,Journal Impact Factor ,business ,Citation - Abstract
Summary Introduction and objectives Vesicoureteral reflux (VUR) has been one of the defining conditions unique to pediatric urology since its inception. The clinical implications of this disease process depend on intrinsic patient factors such as age, genetics, epigenetics, voiding habits, anatomic anomalies, and extrinsic factors such as the pathogenicity of infectious agents. Knowledge about its natural history, the implications of conservative and surgical management, and their associated outcomes have evolved dramatically over time. This study aimed to use bibliometric analyses to summarize the evolution of VUR management over time. In order to accomplish this, the most referenced articles for VUR since 1950 were identified, and a comprehensive analysis of their impact on the management and understanding of VUR was performed by creating a novel impact index. Methods A reference search was carried out for indexed citations through the portal ‘Science Citation Index’ in the subsection ‘Web of Science Core Collection’ using ‘vesicoureteral reflux’ as a MeSH term. References were analyzed and subcategorized according to various subtopics. A unique impact index was developed to adjust the number of publications for the time since publication, in order to define the impact of the paper amongst the most frequently cited papers. Articles were analyzed and data were tabulated according to the number of citations, country and institute of origin, journal of publication, impact factor, and first authorship. Results Citation counts ranged from 43 to 510, and the mean number of citations per publication was 101.43. The most discussed topic was ‘treatment’. The impact index showed that more recent publications have a higher impact. The author with the highest index impact had 271 citations in a period of 5 years. The top 150 articles were published across 23 countries, the majority being from the USA ( Summary fig. ). The most frequently cited institution had 12 publications. The journal with the highest publication referencing rate was the Journal of Urology. Conclusion The most cited articles were valuable sources of information to describe the historical evolution of the pathophysiology and management of VUR. After adjusting for time since publication, the most recent publications (i.e. those published after 1990) had a higher impact index. Combining traditional bibliometric analysis with this novel impact index may allow researchers to optimize future literature analyses, while also assisting clinicians in understanding best practices for patient management based on the available literature. Download : Download high-res image (194KB) Download : Download full-size image Summary fig . Distribution of the 150 most cited papers about VUR worldwide 1950–2016.
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- 2018
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46. Xanthogranulomatous pyelonephritis in a paediatric cohort (1963–2016): Outcomes from a large single-center series
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M.B. McDermott, F.M.J. Quinn, F. O'Kelly, and I. Stoica
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Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Databases, Factual ,Urology ,Urinary system ,medicine.medical_treatment ,030232 urology & nephrology ,Nephrectomy ,Risk Assessment ,Severity of Illness Index ,Cohort Studies ,03 medical and health sciences ,Rare Diseases ,Sex Factors ,0302 clinical medicine ,Recurrence ,Pathognomonic ,030225 pediatrics ,medicine ,Humans ,Child ,Abscess ,Pyelonephritis, Xanthogranulomatous ,Retrospective Studies ,Academic Medical Centers ,Past medical history ,business.industry ,Biopsy, Needle ,Age Factors ,Perioperative ,medicine.disease ,Immunohistochemistry ,Abdominal mass ,Surgery ,Treatment Outcome ,Child, Preschool ,Urinary Tract Infections ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,Differential diagnosis ,Tomography, X-Ray Computed ,business ,Ireland ,Follow-Up Studies - Abstract
Summary Background Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive granulomatous inflammation of the kidney. It was first described in 1916, and is thought to affect 6/1000 cases of pyelonephritis. Its manifestations are varied, and with a limited number of cases in the literature, the optimal diagnosis and management of XGP in the paediatric cohort is still unknown. Material and methods The medical records of children who were diagnosed and treated for XGP at the current unit during the period 1963–2016, inclusive, were retrospectively reviewed. Information pertaining to each patient was recorded, including: demographic data, past medical history, clinical and biochemical characteristics, diagnostic procedures, treatment methods, histopathologic diagnosis of the removed specimen, and outcome. Results A total of 66 children with a median age of 4.84 years (range 1.1–14.81), with an M:F ratio 1.35:1 underwent nephrectomy for XGP and had a median follow-up of 7.19 years (range 0.11–17.45). The most common presentations were systemic illness (62.1%), pain (60.6%), urinary tract infections (54.5%) and an abdominal mass (39.4%); pyrexia was present in 53%. Biochemical abnormalities included anaemia (86.3%), thrombocytosis (80.3%) and hypomagnesemia (65.1%). There was an 83.3% concordance between intraoperative cultures and positive mid-stream urines. Index kidneys were significantly larger than the contralateral side (mean 1.32 cm; P = 0.002). Staging of XGP demonstrated extension beyond the kidney in 79% of kidneys. Computed tomography (CT) was performed in 11 cases (Summary figure). Dimercaptosuccinic acid (DMSA) scan showed 0–10% function in 90.47% of cases. Surgical procedures included nephrectomy (n = 63) and partial nephrectomy (n = 3). Perioperative complications included colonic resections (n = 5) and abscess formation in 18%. Conclusions This is the largest series to date of XGP in a paediatric cohort. XGP should be included in the differential diagnosis of all children presenting with perirenal or psoas abscesses, renal masses and/or non-functioning kidneys with/or without associated urolithiasis. Clinical awareness and a high index of suspicion is required to achieve the correct pre-operative diagnosis and appropriate management. Download : Download high-res image (369KB) Download : Download full-size image Summary Figure . Pathognomonic CT feature of xanthogranulomatous pyelonephritis: ‘bear-paw’ sign.
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- 2018
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47. Gun Shot-101: an 8-year review of gunshot injuries in an Irish teaching hospital from a general surgical perspective
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P. N. Keeling, T. K. Gallagher, P. J. Smyth, F. O’Kelly, and K. T. Lim
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Adult ,Male ,Firearms ,medicine.medical_specialty ,Time Factors ,Adolescent ,Thoracic Injuries ,Exploratory laparotomy ,medicine.medical_treatment ,Poison control ,Abdominal Injuries ,Suicide prevention ,Occupational safety and health ,Young Adult ,Irish ,Risk Factors ,Injury prevention ,Craniocerebral Trauma ,Humans ,Medicine ,Hospitals, Teaching ,Demography ,Retrospective Studies ,business.industry ,General surgery ,Human factors and ergonomics ,Extremities ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Survival Analysis ,language.human_language ,Unemployment ,General Surgery ,language ,Female ,Wounds, Gunshot ,Medical emergency ,business ,Ireland - Abstract
Gun-related crime offences have increased in the Republic of Ireland steadily over the past number of years. Regional trauma units are witnessing unprecedented numbers of injuries in the Republic of Ireland with limited prior experience. Eight-year retrospective study analysing demographic data, management and outcome of firearm-related injuries. Patients who experience gunshot injuries in this region are statistically likely to be young, male and unemployed with a single shotgun injury to an extremity. Post-operative survival rates of 100% for those who undergo an exploratory laparotomy. Ireland has comparable survival outcomes to other international centres with similar patient demographics due to timely and appropriate operative intervention. These results serve to provide a template for further patient management.
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- 2010
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48. Efficacy of vacuum erectile devices (VEDs) after radical prostatectomy: the initial Irish experience of a dedicated VED clinic
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Subhasis K. Giri, Su White, G. P. Smyth, Gregory J. Nason, E. Dunne, M Twyford, F. O’Kelly, F McNamara, G C Durkan, and Richard E. Power
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Male ,medicine.medical_specialty ,Vacuum ,Urology ,medicine.medical_treatment ,Female sexual dysfunction ,030232 urology & nephrology ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Postoperative Complications ,Erectile Dysfunction ,Sexual medicine ,medicine ,Humans ,Retrospective Studies ,Prostatectomy ,030219 obstetrics & reproductive medicine ,business.industry ,Penile Erection ,Prostatic Neoplasms ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Surgery ,Sexual dysfunction ,Erectile dysfunction ,Treatment Outcome ,Patient Satisfaction ,Physical therapy ,medicine.symptom ,Peyronie's disease ,business - Abstract
Controversy exists regarding optimal penile rehabilitation program following radical prostatectomy (RP). Vacuum erectile devices (VEDs) have become an important component of penile rehabilitation protocols. The aim of this study was to assess the efficacy and patient satisfaction of a dedicated VED clinic. A voluntary telephone questionnaire was performed of all patients who attended a VED clinic to date in two university teaching hospitals. Patient demographics, histopathological characteristics and functional status (International Index of Erectile Function (IIEF) scores) were obtained from a retrospective review of a prospectively maintained database. Sixty-five men attended the dedicated VED clinic in the two university teaching hospitals. Forty-men (76.3%) men purchased a VED following the dedicated clinic. There was significant differences noted between the mean preoperative and the 3-month postoperative IIEF scores (22.08±3.16 vs 11.3±3.08, P=0.0001) and between the 3-month postoperative IIEF score and the post-VED use IIEF score (11.3±3.08 vs 16.74±2.62, P=0.0001). Despite VED use, there was a significant reduction in erectile function from presurgery status (22.08±3.16 vs 16.74±2.62, P=0.0001). All patients reported that the dedicated VED was helpful and would recommend it to other patients. Our study demonstrates that, despite a reduction in erectile function after RP, successful erections are attainable with a VED. There is potential and need for the development of a standard penile rehabilitation program and treatment of ED after RP internationally.
- Published
- 2015
49. Rates of self-reported 'burnout' and causative factors amongst urologists in Ireland and the UK: a comparative cross-sectional study
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Alex Reid, Mark Speakman, John A. Thornhill, Rustom P. Manecksha, F. O’Kelly, Kieran O’Flynn, David M. Quinlan, and Adrian D. Joyce
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Male ,medicine.medical_specialty ,Cross-sectional study ,Attitude of Health Personnel ,Urology ,030232 urology & nephrology ,Workload ,Burnout ,Job Satisfaction ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Irish ,Physicians ,Medicine ,Humans ,030212 general & internal medicine ,Hospitals, Teaching ,Burnout, Professional ,Response rate (survey) ,business.industry ,Incidence (epidemiology) ,Stressor ,Health Surveys ,language.human_language ,United Kingdom ,Cross-Sectional Studies ,Vocational education ,Family medicine ,Cohort ,language ,Female ,Self Report ,business ,Ireland ,Stress, Psychological - Abstract
Objectives To determine the incidence of ‘burnout’ among UK and Irish urological consultants and non-consultant hospital doctors (NCHDs). The second objective was to identify possible causative factors and to investigate the impact of various vocational stressors that urologists face in their day-to-day work and to establish whether these correlate with burnout. The third objective was to develop a new questionnaire to complement the Maslach Burnout Inventory (MBI), more specific to urologists as distinct from other surgical/medical specialties, and to use this in addition to the MBI to determine if there is a requirement to develop effective preventative measures for stress in the work place, and develop targeted remedial measures when individuals are affected by burnout. Subjects and methods A joint collaboration was carried out between the Irish Society of Urology (ISU) and the British Association of Urological Surgeons (BAUS). Anonymous voluntary questionnaires were sent to all current registered members of both governing bodies. The questionnaire comprised two parts: the first part encompassed sociodemographic data collection and identifying potential risk factors for burnout, and the second used the MBI to objectively assess for workplace burnout. To evaluate differences in burnout, 2 × 2 contingency tables and Fischer's exact probability tests were used. Results In all, 575 urologists responded to the online survey out of a total of 1380 invites, yielding a 42% response rate. All respondents were aged
- Published
- 2015
50. The effect of social media (#SoMe) on journal impact factor and parental awareness in paediatric urology
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M.J. Leveridge, Walid A. Farhat, Martin A. Koyle, Gregory J. Nason, Salvatore Cascio, Rustom P. Manecksha, F. O'Kelly, F.J. Quinn, and Michael Leonard
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Male ,Parents ,medicine.medical_specialty ,Pediatrics ,Download ,Urology ,030232 urology & nephrology ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Social media ,Child ,Publication ,Impact factor ,business.industry ,Awareness ,030220 oncology & carcinogenesis ,Family medicine ,Pediatrics, Perinatology and Child Health ,Cohort ,Female ,Health education ,The Internet ,Journal Impact Factor ,Periodicals as Topic ,business ,Citation ,Social Media - Abstract
Summary Background Social media (SoMe) comprises a number of internet-based applications that have the capability to disseminate multimodal media and allow for unprecedented inter-user connectivity. The role of Twitter has been studied in conferences and education; moreover, there is increasing evidence that patients are more likely to use social media for their own health education. Objective The aim of this study was to assess the impact of social media platforms on the impact factor of both urological and paediatric journals that publish on paediatric urology, and to assess parental awareness of social media in paediatric urology. Study design A filtered Journal of Citation Reports (JCR) search was performed for the period 2012–16 for journals that published articles on paediatric urology. Journals were ranked according to impact factor, and each individual journal website was accessed to assess for the presence of social media. Parents in paediatric urology clinics and non-paediatric urology patients also filled out a questionnaire to assess for awareness and attitudes to social media. All statistical analysis was performed using Prism 6 software (Prism 6, GraphPad Software, California, USA). Results Overall, there were 50 urological journals and 39 paediatric journals with a mean impact factor of 2.303 and 1.766, respectively. There was an overall average increase in impact factor across all urological journals between 2012 and 16. The presence of a Twitter feed was statistically significant for a rise in impact factor over the 4 years (P = 0.017). The cohort of parents was statistically more likely to have completed post-secondary education, to have and access to a social media profile, use it for health education, and use it to access journal/physician/hospital social media accounts. Discussion This study examined, for the first time, the role of social media in paediatric urology, and demonstrated that SoMe use is associated with a positive influence in impact factor, but also a parental appetite for it. Limitations included a non-externally validated questionnaire. There may also have been bias in larger journals that generate and maintain social media platforms such as Twitter, which may then in turn have an influence on impact factor. Conclusions Social media use within paediatric urology was associated with a higher impact factor, which remained significant after 4 years of analysis. Parents were more likely to use a wide variety of social media to search for conditions and physicians/healthcare providers; therefore, journals and institutions need to embrace and endorse SoMe as a potential source of important clinical information. Download : Download high-res image (60KB) Download : Download full-size image
- Published
- 2017
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