Search

Your search keyword '"F. O’Donovan"' showing total 37 results
Start Over Author "F. O’Donovan"
37 results on '"F. O’Donovan"'

1. Ireland’s national school system in the time of the Great Famine: an overview

Author

Patrick F. O’Donovan

Subjects
National education, Economic growth, History and Philosophy of Science, Salient, Political science, Famine, School system, Education
Abstract

This article traces the functioning of the Commissioners of National Education, outlining salient aspects of their activities in the national school system during Ireland’s Great Famine of the 1840...

Published
2021

2. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Author

Marshall, Christian R. Howrigan, Daniel P. Merico, Daniele and Thiruvahindrapuram, Bhooma Wu, Wenting Greer, Douglas S. and Antaki, Danny Shetty, Aniket Holmans, Peter A. Pinto, Dalila and Gujral, Madhusudan Brandler, William M. Malhotra, Dheeraj and Wang, Zhouzhi Fajarado, Karin V. Fuentes Maile, Michelle S. and Ripke, Stephan Agartz, Ingrid Albus, Margot Alexander, Madeline Amin, Farooq Atkins, Joshua Bacanu, Silviu A. and Belliveau, Jr., Richard A. Bergen, Sarah E. Ertalan, Marcelo and Bevilacqua, Elizabeth Bigdeli, Tim B. Black, Donald W. and Bruggeman, Richard Buccola, Nancy G. Buckner, Randy L. and Bulik-Sullivan, Brendan Byerley, William Cahn, Wiepke Cai, Guiqing Cairns, Murray J. Campion, Dominique Cantor, Rita M. and Carr, Vaughan J. Carrera, Noa Catts, Stanley V. and Chambert, Kimberley D. Cheng, Wei Cloninger, C. Robert and Cohen, David Cormican, Paul Craddock, Nick Crespo-Facorro, Benedicto Crowley, James J. Curtis, David Davidson, Michael and Davis, Kenneth L. Degenhardt, Franziska Del Favero, Jurgen and DeLisi, Lynn E. Dikeos, Dimitris Dinan, Timothy and Djurovic, Srdjan Donohoe, Gary Drapeau, Elodie Duan, Jubao and Dudbridge, Frank Eichhammer, Peter Eriksson, Johan and Escott-Price, Valentina Essioux, Laurent Fanous, Ayman H. and Farh, Kai-How Farrell, Martilias S. Frank, Josef Franke, Lude Freedman, Robert Freimer, Nelson B. Friedman, Joseph I. and Forstner, Andreas J. Fromer, Menachem Genovese, Giulio and Georgieva, Lyudmila Gershon, Elliot S. Giegling, Ina and Giusti-Rodriguez, Paola Godard, Stephanie Goldstein, Jacqueline I. Gratten, Jacob de Haan, Lieuwe Hamshere, Marian L. and Hansen, Mark Hansen, Thomas Haroutunian, Vahram Hartmann, Annette M. Henskens, Frans A. Herms, Stefan Hirschhorn, Joel N. Hoffinann, Per Hofman, Andrea Huang, Hailiang Ikeda, Masashi Joa, Inge Kahler, Anna K. Kahn, Rene S. and Kalaydjieva, Luba Karjalainen, Juha Kavanagh, David Keller, Matthew C. Kelly, Brian J. Kennedy, James L. Kim, Yunjung and Knowles, James A. Konte, Bettina Laurent, Claudine Lee, Phil Lee, S. Hong Legge, Sophie E. Lerer, Bernard Levy, Deborah L. Liang, Kung-Yee Lieberman, Jeffrey Lonnqvist, Jouko Loughland, Carmel M. Magnusson, Patrik K. E. Maher, Brion S. Maier, Wolfgang Mallet, Jacques Mattheisen, Manuel and Mattingsdal, Morten McCarley, Robert W. McDonald, Colm and McIntosh, Andrew M. Meier, Sandra Meijer, Carin J. Melle, Ingrid Mesholam-Gately, Raquelle I. Metspalu, Andres Michie, Patricia T. Milani, Lili Milanova, Vihra Mokrab, Younes and Morris, Derek W. Muller-Myhsok, Bertram Murphy, Kieran C. and Murray, Robin M. Myin-Germeys, Inez Nenadic, Igor Nertney, Deborah A. Nestadt, Gerald Nicodemus, Kristin K. Nisenbaum, Laura Nordin, Annelie O'Callaghan, Eadbhard O'Dushlaine, Colm Oh, Sang-Yun Olincy, Ann Olsen, Line O'Neill, F. Anthony Van Os, Jim Pantelis, Christos Papadimitriou, George N. Parkhomenko, Elena Pato, Michele T. Paunio, Tiina and Perkins, Diana O. Pers, Tune H. Pietilainen, Olli Pimm, Jonathan Pocklington, Andrew J. Powell, John Price, Alkes and Pulver, Ann E. Purcell, Shaun M. Quested, Digby and Rasmussen, Henrik B. Reichenberg, Abraham Reimers, Mark A. and Richards, Alexander L. Roffman, Joshua L. Roussos, Panos and Ruderfer, Douglas M. Salomaa, Veikko Sanders, Alan R. and Savitz, Adam Schall, Ulrich Schulze, Thomas G. Schwab, Sibylle G. Scolnick, Edward M. Scott, Rodney J. Seidman, Larry J. Shi, Jianxin Silverman, Jeremy M. Smoller, Jordan W. Soderman, Erik Spencer, Chris C. A. Stahl, Eli A. and Strengman, Eric Strohmaier, Jana Stroup, T. Scott Suvisaari, Jaana Svrakic, Dragan M. Szatkiewicz, Jin P. Thirumalai, Srinivas Tooney, Paul A. Veijola, Juha Visscher, Peter M. and Waddington, John Walsh, Dermot Webb, Bradley T. Weiser, Mark Wildenauer, Dieter B. Williams, Nigel M. Williams, Stephanie Witt, Stephanie H. Wolen, Aaron R. Wormley, Brandon K. Wray, Naomi R. Wu, Jing Qin Zai, Clement C. and Adolfsson, Rolf Andreassen, Ole A. Blackwood, Douglas H. R. and Bramon, Elvira Buxbaum, Joseph D. Cichon, Sven Collier, David A. Corvin, Aiden Daly, Mark J. Darvasi, Ariel and Domenici, Enrico Esko, Tonu Gejman, Pablo V. Gill, Michael and Gurling, Hugh Hultman, Christina M. Iwata, Nakao and Jablensky, Assen V. Jonsson, Erik G. Kendler, Kenneth S. and Kirov, George Knight, Jo Levinson, Douglas F. Li, Qingqin S. and McCarroll, Steven A. McQuillin, Andrew Moran, Jennifer L. and Mowry, Bryan J. Nothen, Markus M. Ophoff, Roel A. Owen, Michael J. Palotie, Aarno Pato, Carlos N. Petryshen, Tracey L. Posthuma, Danielle Rietschel, Marcella Riley, Brien P. and Rujescu, Dan Sklar, Pamela St Clair, David Walters, James T. R. Werge, Thomas Siillivan, Patrick F. O'Donovan, Michael C. Scherer, Stephen W. Neale, Benjamin M. Sebat, Jonathan CNV Schizophrenia Working Grp Psychosis Endophenotypes

Abstract

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 x 10(-15)), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 x 10(-6)). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 x 10(-11)) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 x 10(-5)). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.

Published
2017

4. Biological insights from 108 schizophrenia-associated genetic loci

Author

Ripke, Stephan Neale, Benjamin M. Corvin, Aiden Walters, James T. R. Farh, Kai-How Holmans, Peter A. Lee, Phil and Bulik-Sullivan, Brendan Collier, David A. Huang, Hailiang and Pers, Tune H. Agartz, Ingrid Agerbo, Esben Albus, Margot and Alexander, Madeline Amin, Farooq Bacanu, Silviu A. Begemann, Martin Belliveau, Jr., Richard A. Bene, Judit Bergen, Sarah E. Bevilacqua, Elizabeth Bigdeli, Tim B. Black, Donald W. and Bruggeman, Richard Buccola, Nancy G. Buckner, Randy L. and Byerley, William Cahn, Wiepke Cai, Guiqing Campion, Dominique Cantor, Rita M. Carr, Vaughan J. Carrera, Noa and Catts, Stanley V. Chambert, Kimberly D. Chan, Raymond C. K. and Chen, Ronald Y. L. Chen, Eric Y. H. Cheng, Wei Cheung, Eric F. C. Chong, Siow Ann Cloninger, C. Robert Cohen, David and Cohen, Nadine Cormican, Paul Craddock, Nick Crowley, James J. Curtis, David Davidson, Michael Davis, Kenneth L. and Degenhardt, Franziska Del Favero, Jurgen Demontis, Ditte and Dikeos, Dimitris Dinan, Timothy Djurovic, Srdjan Donohoe, Gary Drapeau, Elodie Duan, Jubao Dudbridge, Frank and Durmishi, Naser Eichhammer, Peter Eriksson, Johan and Escott-Price, Valentina Essioux, Laurent Fanous, Ayman H. and Farrell, Martilias S. Frank, Josef Franke, Lude Freedman, Robert Freimer, Nelson B. Friedl, Marion Friedman, Joseph I. and Fromer, Menachem Genovese, Giulio Georgieva, Lyudmila and Giegling, Ina Giusti-Rodriguez, Paola Godard, Stephanie and Goldstein, Jacqueline I. Golimbet, Vera Gopal, Srihari and Gratten, Jacob de Haan, Lieuwe Hammer, Christian Hamshere, Marian L. Hansen, Mark Hansen, Thomas Haroutunian, Vahram and Hartmann, Annette M. Henskens, Frans A. Herms, Stefan and Hirschhorn, Joel N. Hoffmann, Per Hofman, Andrea Hollegaard, Mads V. Hougaard, David M. Ikeda, Masashi Joa, Inge and Julia, Antonio Kahn, Rene S. Kalaydjieva, Luba and Karachanak-Yankova, Sena Karjalainen, Juha Kavanagh, David and Keller, Matthew C. Kennedy, James L. Khrunin, Andrey Kim, Yunjung Klovins, Janis Knowles, James A. Konte, Bettina and Kucinskas, Vaidutis Kucinskiene, Zita Ausrele Kuzelova-Ptackova, Hana Kahler, Anna K. Laurent, Claudine Keong, Jimmy Lee Chee and Lee, S. Hong Legge, Sophie E. Lerer, Bernard Li, Miaoxin and Li, Tao Liang, Kung-Yee Lieberman, Jeffrey Limborska, Svetlana Loughland, Carmel M. Lubinski, Jan Lonnqvist, Jouko and Macek, Jr., Milan Magnusson, Patrik K. E. Maher, Brion S. and Maier, Wolfgang Mallet, Jacques Marsal, Sara Mattheisen, Manuel Mattingsdal, Morten McCarley, Robert W. McDonald, Colm McIntosh, Andrew M. Meier, Sandra Meijer, Carin J. and Melegh, Bela Melle, Ingrid Mesholam-Gately, Raquelle I. and Metspalu, Andres Michie, Patricia T. Milani, Lili Milanova, Vihra Mokrab, Younes Morris, Derek W. Mors, Ole Murphy, Kieran C. Murray, Robin M. Myin-Germeys, Inez and Mueller-Myhsok, Bertram Nelis, Mari Nenadic, Igor Nertney, Deborah A. Nestadt, Gerald Nicodemus, Kristin K. and Nikitina-Zake, Liene Nisenbaum, Laura Nordin, Annelie and O'Callaghan, Eadbhard O'Dushlaine, Colm O'Neill, F. Anthony and Oh, Sang-Yun Olincy, Ann Olsen, Line Van Os, Jim and Pantelis, Christos Papadimitriou, George N. Papiol, Sergi and Parkhomenko, Elena Pato, Michele T. Paunio, Tiina and Pejovic-Milovancevic, Milica Perkins, Diana O. Pietilainen, Olli and Pimm, Jonathan Pocklington, Andrew J. Powell, John and Price, Alkes Pulver, Ann E. Purcell, Shaun M. Quested, Digby and Rasmussen, Henrik B. Reichenberg, Abraham Reimers, Mark A. and Richards, Alexander L. Roffman, Joshua L. Roussos, Panos and Ruderfer, Douglas M. Salomaa, Veikko Sanders, Alan R. and Schall, Ulrich Schubert, Christian R. Schulze, Thomas G. and Schwab, Sibylle G. Scolnick, Edward M. Scott, Rodney J. and Seidman, Larry J. Shi, Jianxin Sigurdsson, Engilbert and Silagadze, Teimuraz Silverman, Jeremy M. Sim, Kang and Slominsky, Petr Smoller, Jordan W. So, Hon-Cheong Spencer, Chris C. A. Stahl, Eli A. Stefansson, Hreinn Steinberg, Stacy Stogmann, Elisabeth Straub, Richard E. Strengman, Eric and Strohmaier, Jana Stroup, T. Scott Subramaniam, Mythily and Suvisaari, Jaana Svrakic, Dragan M. Szatkiewicz, Jin P. and Soderman, Erik Thirumalai, Srinivas Toncheva, Draga Tosato, Sarah Veijola, Juha Waddington, John Walsh, Dermot Wang, Dai Wang, Qiang Webb, Bradley T. Weiser, Mark and Wildenauer, Dieter B. Williams, Nigel M. Williams, Stephanie and Witt, Stephanie H. Wolen, Aaron R. Wong, Emily H. M. and Wormley, Brandon K. Xi, Hualin Simon Zai, Clement C. Zheng, Xuebin Zimprich, Fritz Wray, Naomi R. Stefansson, Kari and Visscher, Peter M. Adolfsson, Rolf Andreassen, Ole A. and Blackwood, Douglas H. R. Bramon, Elvira Buxbaum, Joseph D. and Borglum, Anders D. Cichon, Sven Darvasi, Ariel Domenici, Enrico Ehrenreich, Hannelore Esko, Tonu Gejman, Pablo V. and Gill, Michael Gurling, Hugh Hultman, Christina M. Iwata, Nakao Jablensky, Assen V. Jonsson, Erik G. Kendler, Kenneth S. Kirov, George Knight, Jo Lencz, Todd Levinson, Douglas F. Li, Qingqin S. Liu, Jianjun Malhotra, Anil K. and McCarroll, Steven A. McQuillin, Andrew Moran, Jennifer L. and Mortensen, Preben B. Mowry, Bryan J. Noethen, Markus M. and Ophoff, Roel A. Owen, Michael J. Palotie, Aarno Pato, Carlos N. Petryshen, Tracey L. Posthuma, Danielle Rietschel, Marcella Riley, Brien P. Rujescu, Dan Sham, Pak C. and Sklar, Pamela St Clair, David Weinberger, Daniel R. and Wendland, Jens R. Werge, Thomas Daly, Mark J. Sullivan, Patrick F. O'Donovan, Michael C. Psychiat Genomics Consortium and Psychosis Endophenotypes Int Conso Wellcome Trust Case-Control Consor

Abstract

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

Published
2014

5. MON-P066: Malnutrition and Body Composition Predicts Poor Quality of Life and Reduced Survival in Ambulatory Oncology Patients Receiving Chemotherapy: A Cross Sectional Study of 820 Patients

Author

Derek G. Power, Louise E. Daly, E. Ni Bhuachalla, F. O'Donovan, Aoife M. Ryan, Peter MacEneaney, and S. Cushen

Subjects
Pediatrics, medicine.medical_specialty, Chemotherapy, Nutrition and Dietetics, Cross-sectional study, business.industry, medicine.medical_treatment, Critical Care and Intensive Care Medicine, medicine.disease, Poor quality, Malnutrition, Ambulatory, medicine, Oncology patients, Intensive care medicine, business
Published
2016

7. ChemInform Abstract: The Structure of Fullerene Compounds

Author

A. D. Darwish, A. G. Avent, M. F. Meidine, Harold W. Kroto, Ana M. Benito, P. B. Hitchcock, Paul R. Birkett, Kosmas Prassides, I. W. Locke, and B. F. O'donovan

Subjects
Fullerene, Computational chemistry, Chemistry, General Medicine
Published
2010

8. Royal Academy of Medicine in Ireland Section of Biological Sciences Proceedings of Winter Meeting at Earlsfort Terrace, University College Dublin, 4th January 1991

Author

D. Phelan, Angela M. Carragher, P. S. Collier, James A. Houghton, F. Finian Martin, D. P. Nicholls, D. Cottell, C. H. Homer, John Feely, Roger Anwyl, B. Mokhtar, L. Penney, D. C. Moriarty, F. Ryan, M. Reilly, Noreen Gleeson, R. Gonsalves, E. O’Leary, G. Fitzpatrick, R. P. Barrett, J. Mahon, C. McCaul, Patrick J. Gaffney, S. F. Craig, John Bannigan, J. R. P. Gibbons, B. J. Chambers, P. S. Gascoine, Maura Grealy, J. Bourke, D. Doherty, James Bernard Walsh, Catherine A. Martin, M. Kelly, P. O’Keane, T. P. Crotty, G. D. Baxter, J.P.H. Fee, B. L. Sheppard, N. McDonald, S. C. Sharma, E. McGuinness, C. Doolan, M. B. Lambert, W. J. Hall, Marie Jordan, L. Keegan, M. O’Brien, John Kelly, D. O’Mahony, Aidan Bradford, A. J. McShane, D. Mannion, R.S.J. Clarke, W. P. Blunnie, W. P. Abram, J. M. Allen, P. M. Tymkewycz, J. A. McGuigan, Michael J. Rowan, Anne-Marie Nugent, John Bonnar, T. Grimm, C. Longstaff, J. A. Parmo, C. Boyle, Elinor Arbuthnott, J. M. O’Donnell, J. Quigley, J. Ravey, F. O’Donovan, Brian E. Leonard, A. J. Bell, Deirdre Cooney, L. J. Creighton-Kempsford, Elizabeth F. Hall, K. Prasanna, F. Kirby, K. McGrath, D. Coakley, J. B. Pring, A. A. M. Omara, M. S. McKinney, John W. Dundee, C. M. McMillan, C. M. Cooney, A. K. Keenan, Anne Burke-Gaffney, R. Chan, K. Mulpeter, Lucy A. Norris, E. McKone, P. B. Deasy, and N. W. Klein

Subjects
geography, geography.geographical_feature_category, Terrace (geology), business.industry, Section (archaeology), Medicine, General Medicine, business, Biological sciences, Archaeology
Published
1991

9. Per-urethral transvesical first-trimester amniocentesis

Author

Hervé Fernandez, M. Le Lorc'h, J.C. Pons, F O'Donovan, F. Olivennes, Jacqueline Selva, René Frydman, and E. Borghi

Subjects
medicine.medical_specialty, Amniotic fluid, Urinary Bladder, Prenatal diagnosis, Urethra, Pregnancy, medicine, Humans, Urinary bladder, medicine.diagnostic_test, Obstetrics, business.industry, Obstetrics and Gynecology, medicine.disease, Surgery, Pregnancy Trimester, First, medicine.anatomical_structure, Reproductive Medicine, Amniocentesis, Gestation, Amenorrhea, Female, medicine.symptom, business
Abstract

Early amniocentesis (before 13 weeks' gestation) using a per-urethral transvesical route is studied. Eight samples were obtained in eight patients scheduled for elective termination of pregnancy. The volume of amniotic fluid averaged 12.5 +/- 7.8 ml. Culture was successful in all samples. In one case, culture was achieved with only 2 ml of amniotic fluid. The amniotic fluid can be easily obtained via the per-urethral transvesical route. We conclude that early per-urethral amniocentesis before 13 weeks amenorrhea may be an alternative to the transabdominal route. A clinical trial should be carried out in order to evaluate both techniques.

Published
1993

10. [Criteria of recovery from caudal anesthesia in children]

Author

S, Saint-Raymond, F, O'Donovan, and C, Ecoffey

Subjects
Analgesia, Epidural, Pain, Postoperative, Ambulatory Surgical Procedures, Child, Preschool, Anesthesia Recovery Period, Nitrous Oxide, Humans, Infant, Anesthesia, Inhalation, Child, Halothane, Bupivacaine
Abstract

The authors evaluated the return of sensory, motor, and sympathetic nervous system function following caudal block in children. Twenty children, ASA PS I, aged 5 +/- 4 yr (mean +/- SD), weighing 22 +/- 9 kg, scheduled for lower abdominal and urologic surgical procedures were studied. Anaesthesia was induced and maintained by halothane, N2O and oxygen. A caudal block was performed with 1 ml/kg of 0.25% bupivacaine. Analgesia assessed by Broadman's score was efficient in 18 out of the 20 children during the first 4 hours after the block. Upper level of cutaneous analgesia was T10 +/- 2 after the block. Two hours after the caudal injection an incomplete motor blockade was found in 14 of 20 children, and at 4 hours no block was found in any child. Heart rate was significantly increased in the upright position (122 +/- 12 to 131 +/- 26 bpm at 2 hours, and 110 +/- 21 to 118 +/- 28 bpm at 4 hours), whereas arterial blood pressure was unchanged in the upright position.

Published
1990

11. Phosphine-catalysed cycloaddition of buta-2,3-dienoates and but-2-ynoates to [60]fullerene

Author

Peter B. Hitchcock, Mohamed F. Meidine, Harold W. Kroto, David R. M. Walton, Bryan F. O’Donovan, and Roger Taylor

Subjects
Fullerene, Chemistry, Metals and Alloys, General Chemistry, Medicinal chemistry, Catalysis, Cycloaddition, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, Materials Chemistry, Ceramics and Composites, Organic chemistry, Phosphine
Abstract

In the presence of phosphine catalysts, ethyl buta-2,3-dienoate and ethyl but-2-ynoate undergo [3 + 2] as opposed to [2 + 2] dipolar cycloaddition to [60]fullerene.

Published
1997

14. Use of Fresh or Frozen Cow Faeces Instead of Sheep Rumen Liquor to Provide Mocroorganisms for in Vitro Digestiblity Assays of Forages

Author

A Fall, S Akhter, M K Theodorou, F O'Donovan, and E Owen

Subjects
Rumen, Animal science, General Medicine, Biology, Feces, In vitro
Abstract

Current techniques for in vitro digestion of forages depend on the use of rumen fistulated animals to supply microbial suspensions in rumen liquor. The objective of the present study is to develop a noninvasive alternative to rumen liquor as a source of micro-organisms in the two-stage, in vitro digestion technique of Tilley and Terry (1963).EL Shaer, Omed, Chamberlain and Axford (1987) showed a high correlation between digestibility in vitro determined using micro-organisms from rumen liquor and from freshly-voided sheep faeces. The disadvantages of using sheep faeces are (a) the need for fresh faeces, (b) the small quantities voided at any given time and (c) the difficulty of enticing sheep to defaecate at a specific time.Cow faeces as a source of micro-organisms was investigated in the present study because of the ease of collecting a large quantity of freshly-voided faeces at a given time. Another objective of the present study was to investigate whether faeces could be frozen and stored for future use as a source of micro-organisms for the in vitro digestibility assay. A further objective was to investigate whether rumen liquor could be frozen and stored for future use.

Published
1994

16. Pituitary Hypogonadism with Adrenal Androgen Deficiency: The Effect of Chorionic Gonadotropin on 17-Ketosteroid Excretion*

Author

Timothy F. O'donovan and Laurence H. Kyle

Subjects
medicine.medical_specialty, Pituitary gland, medicine.drug_class, business.industry, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Disease, Androgen, medicine.disease, Biochemistry, Endocrinology, medicine.anatomical_structure, Internal medicine, Androgen deficiency, medicine, Endocrine system, Gonadotropin, Luteinizing hormone, business, Rectal Polyp
Abstract

PATIENTS with unusual combinations of congenital anomalies and endocrinologic disease are always of interest, especially if the disorder is of such a type as to increase our knowledge of the interaction of endocrine systems. The case presented here showed an illuminating clinical picture in this respect. More important, however, was the fact that the endocrine defect was of such a nature as to allow the test of the hypothesis that adrenal androgen production is under the control of the luteinizing hormone. Of further significance was the occurrence, during therapy with chorionic gonadotropin, of changes indicative of estrin secretion. CASE REPORT A 19-year-old colored female was admitted to the Surgical Service of Georgetown University Hospital for removal of a rectal polyp. Because of apparent hypogenitalism she was transferred to the Medical Service for further study. Past history: Birth by spontaneous delivery was said to have been uneventful, and early development was normal. During childhood the pati...

Published
1950

17. [Ambulatory monitoring and telephone transmission of uterine activity. Preliminary study on the evaluation of the TOKOS system]

Author

J C, Pons, C, Chave, J L, Benifla, P, Diochin, F, O'Donovan, and E, Papiernik

Subjects
Adult, Uterine Contraction, Evaluation Studies as Topic, Pregnancy, Reference Values, Modems, Humans, Female, Monitoring, Physiologic, Telephone
Abstract

The authors compare 100 tracings of uterine contractions, recorded using a mobile monitoring apparatus with telephone output TOKOS System), with 100 tracings recorded using static equipment. The TOKOS system is useful in diagnosis of uterine contraction, being equivalent to the reference system. The TOKOS system is superior to the reference system in that it allows the intensity of the contractions to be evaluated. The TOKOS system is an original approach to maternal perception of uterine activity. Overall, 28% of contractions are identified by the patient. The authors conclude that the tracings produced by the TOKOS system are more reliable than maternal perception of uterine contractions.

Published
1988

19. The structure of fullerene compounds

Author

Peter B. Hitchcock, Robert A. Taylor, I. W. Locke, M. F. Meidine, Harold W. Kroto, Paul R. Birkett, D. R. M. Walton, Anthony G. Avent, M. van Wijnkoop, Ana M. Benito, Adam D. Darwish, B. F. O'donovan, and Kosmas Prassides

Subjects
chemistry.chemical_classification, Fullerene chemistry, Fullerene, Double bond, Organic Chemistry, Halogenation, Combinatorial chemistry, Medicinal chemistry, Cycloaddition, Analytical Chemistry, Inorganic Chemistry, Electrophilic substitution, chemistry.chemical_compound, chemistry, Spectroscopy, Alkyl, Phosphine
Abstract

This account reviews fullerene chemistry research at Sussex. C 60 Ph 2 and C 60 Ph 4 have been isolated as minor products from the reaction of C 60 Cl 6 with C 6 H 6 and FeCl 3 . [70]Fullerene reacts with ICl in C 6 H 6 producing a single isomer of C 70 Cl 10 in high yield. C 70 Ph 8 , which has a [5,6] cage double bond that can be selectively functionalized, or C 70 Ph 10 are produced by the electrophilic substitution of C 70 Cl 10 into C 6 H 6 in the presence of FeCl 3 . C 70 Ph 9 OH is isolated as a minor component of foregoing reaction mixtures. Autoxidation of C 70 Ph 8 yields the bislactone, C 70 Ph 8 O 4 , which has an eleven atom ring in the surface of the cage, Cycloaddition to the [5,6] double bond of C 70 Ph 8 with anthracene, C 14 H 10 , in C 6 H 6 produces C 70 Ph 8 (C 14 H 10 ). Two new methanofullerenes, C 60 (CBr 2 ), and C 60 (CHCN), are produced by treating [60]fullerene in C 6 H 6 with either CH 2 BrCN or CHBr 2 in the presence of LDA. Reaction of [60]fullerene with alkyl buta-2,3-dienoates in the presence of a phosphine results in [3 + 2] cycloadditions which produce alkyl 3′H-1,2-([1′,2′]cyclopenta)[60]fullerene-5′-carboxylates. [60]Fullerene reacts with Pt(cod) 2 , producing an insoluble precipitate of PtC 60 , further reaction with the bidentate ligand, Ph 2 P(CH 2 ) n PPh 2 ) [ n = 2 or 3] in PhMe yields the low solubility complexes Pt( η 2 -C 60 )[Ph 2 P(CH 2 ) n PPh 2 )] ( n = 2 or 3). Mixing of C 6 H 6 solutions of [60]fullerene with P 4 or vapour-solid reaction of [60]fullerene with P 4 results in the formation of the intercalate C 60 (P 4 ) 2 ; there is no evidence for significant charge-transfer between the donor (P 4 ) and acceptor (C 60 ) molecules.

21. Prehospital Sudden Death: Need for Immediate Effective Resuscitation

Author

Philippe Meyer, F. O'donovan, Jean Marie Caussanel, and Olivier Lamour

Subjects
Resuscitation, medicine.medical_specialty, business.industry, medicine.medical_treatment, Sudden death, Coronary circulation, medicine.anatomical_structure, Acute care, Internal Medicine, medicine, Cardiopulmonary resuscitation, Young adult, Intensive care medicine, business, Clinical death, Cardiac asystole
Abstract

To the Editor .—In a recent article, Raymond and co-workers 1 reported a study of nontraumatic sudden death in young adults occurring outside of the hospital. It must be noted that all patients in this study were managed at the scene by nonphysicians who performed cardiopulmonary resuscitation (CPR). The mean time between cardiac arrest and therapeutic management in the emergency room was 40 minutes. Among 83 patients, 75% were admitted to the hospital with clinical evidence of death or noneffective cardiac rhythm and, in spite of aggressive resuscitation by acute care physicians in the emergency room, could not be revived. It is not surprising that no positive result could be obtained after such a long time without effective coronary circulation in 25 patients reaching the hospital with cardiac asystole. We do agree with the authors that the most predominant prognostic factor is not the initial rhythm observed at the scene

Published
1989

22. Simulation and the Monte Carlo Method

Author

Reuven Y. Rubinstein and Thomas M. F. O'Donovan

Subjects
Statistics and Probability, General Immunology and Microbiology, Computer science, Applied Mathematics, Monte Carlo method, General Medicine, Statistical physics, General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology
Published
1983

25. Preventing and countering the interference of tobacco industry: Recommendations from the Joint Action on Tobacco Control 2.

Author

Solimini R, Ollila H, Gallus S, Havermans A, Talhout R, Kilibarda B, Vasic M, Fernández E, Carnicer-Pont D, Lopez AM, Pérez-Sacristán EM, Cselko Z, Mulcahy M, and O'Donovan-Sadat F

Abstract

Competing Interests: The authors have each completed and submitted an ICMJE form for Disclosure of Potential Conflicts of Interest and none was reported.

Published
2024
Full Text
View/download PDF

26. The Joint Action on Tobacco Control: A cooperation project for strengthening tobacco control in Europe.

Author

Straarup MS, O'Donovan F, Lambrou A, Weber C, Gebetsberger-Hartleitner I, Solimini R, Labarbe B, Lange CC, Stærmose S, Staal YCM, Havermans A, Fernandez E, Carnicer-Pont D, Tigova O, and Ollila H

Abstract

Competing Interests: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none was reported.

Published
2022
Full Text
View/download PDF

27. Omega-3 index and blood pressure responses to eating foods naturally enriched with omega-3 polyunsaturated fatty acids: a randomized controlled trial.

Author

Stanton AV, James K, Brennan MM, O'Donovan F, Buskandar F, Shortall K, El-Sayed T, Kennedy J, Hayes H, Fahey AG, Pender N, Thom SAM, Moran N, Williams DJ, and Dolan E

Subjects
Adolescent, Adult, Double-Blind Method, Energy Intake, Fatty Acids, Omega-3 administration & dosage, Female, Humans, Male, Middle Aged, Seafood analysis, Young Adult, Blood Pressure, Diet, Eating physiology, Eggs analysis, Fatty Acids, Omega-3 analysis, Food, Fortified, Meat analysis
Abstract

Diets low in seafood omega-3 polyunsaturated fatty acids (PUFAs) are very prevalent. Such diets have recently been ranked as the sixth most important dietary risk factor-1.5 million deaths and 33 million disability-adjusted life-years worldwide are attributable to this deficiency. Wild oily fish stocks are insufficient to feed the world's population, and levels of eicosapentaenoic acid and docosahexaenoic acid (DHA) in farmed fish have more than halved in the last 20 years. Here we report on a double-blinded, controlled trial, where 161 healthy normotensive adults were randomly allocated to eat at least three portions/week of omega-3-PUFA enriched (or control) chicken-meat, and to eat at least three omega-3-PUFA enriched (or control) eggs/week, for 6 months. We show that regular consumption of omega-3-PUFA enriched chicken-meat and eggs significantly increased the primary outcome, the red cell omega-3 index (mean difference [98.75% confidence interval] from the group that ate both control foods, 1.7% [0.7, 2.6]). Numbers of subjects with a very high-risk omega-3 index (index < 4%) were more than halved amongst the group that ate both enriched foods. Furthermore, eating the enriched foods resulted in clinically relevant reductions in diastolic blood pressure (- 3.1 mmHg [- 5.8, - 0.3]). We conclude that chicken-meat and eggs, naturally enriched with algae-sourced omega-3-PUFAs, may serve as alternative dietary sources of these essential micronutrients. Unlike many lifestyle interventions, long-term population health benefits do not depend on willingness of individuals to make long-lasting difficult dietary changes, but on the availability of a range of commonly eaten, relatively inexpensive, omega-3-PUFA enriched foods.

Published
2020
Full Text
View/download PDF

28. Anesthesia for sickle cell disease and congenital myopathy in combination.

Author

Fanning R, O'Donnell B, Lynch B, Stephens M, and O'Donovan F

Subjects
Anesthesia, General adverse effects, Arthrogryposis complications, Child, Preschool, Circumcision, Male, Clubfoot complications, Exchange Transfusion, Whole Blood, Humans, Male, Neuromuscular Junction Diseases congenital, Orthopedic Procedures, Perioperative Care, Tourniquets, Anemia, Sickle Cell complications, Anesthesia, Conduction methods, Arthrogryposis surgery, Clubfoot surgery, Neuromuscular Junction Diseases complications
Abstract

We report on the perioperative management of anesthesia and analgesia in a child with sickle cell disease and a congenital myopathy, presenting for corrective orthopedic surgery. The case illustrates two valuable points of interest: the many benefits of regional anesthesia in complex medical cases and the successful use of tourniquets in children with sickle cell disease.

Published
2006
Full Text
View/download PDF

29. Hereditary coproporphyria: case report of an acute crisis.

Author

McDonnell C and O'Donovan F

Subjects
Adolescent, Calcium Channel Blockers adverse effects, Coproporphyria, Hereditary chemically induced, Coproporphyria, Hereditary therapy, Female, Humans, Nifedipine adverse effects, Coproporphyria, Hereditary physiopathology
Published
2005

30. Clonidine at induction reduces shivering after general anaesthesia.

Author

Buggy D, Higgins P, Moran C, O'Donovan F, and McCarroll M

Subjects
Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Adrenergic alpha-Agonists pharmacology, Anesthesia, General adverse effects, Clonidine pharmacology, Shivering drug effects
Abstract

Purpose: Postanaesthetic shivering occurs in 5-65% of patients. In addition to causing discomfort, it is associated with deleterious consequences. Our objective was to investigate the effect of 150 micrograms clonidine, at induction of anaesthesia, on perioperative core and peripheral temperature, incidence of postanaesthetic shivering and patients' perception of cold., Methods: Sixty ASA 1 or 2 patients scheduled for elective orthopaedic limb surgery were randomly allocated to group 1, who received 150 micrograms clonidine iv, or group 2, who received a saline bolus iv, before induction. In all patients, anaesthesia was induced with fentanyl and propofol and maintained by spontaneous respiration (via a laryngeal mask airway) of oxygen, nitrous oxide and enflurane. Core (nasopharyngeal) and peripheral (dorsal hand) temperatures were recorded at induction and 15-min intervals. Nurses, unaware of the treatment groups, recorded visible shivering in the recovery room. When cognitive function returned, patients were asked to grade their perception of cold on a 10 cm linear analogue scale, higher scores indicating heat discomfort., Results: While core temperature decreased and peripheral temperature increased in both groups, there was no difference between the groups at any time. However, there was a lower incidence of shivering in the clonidine group (20% vs 66.7%, P < 0.001). Patients receiving clonidine felt warmer; thermal comfort score (median interquartile range) 5.9 (5.0-7.2) vs 5.0 (4.5-6.0), P < 0.05)., Conclusion: Clonidine 150 g iv at induction of anaesthesia reduces the incidence of shivering and patients' subjective perception of cold on emergence from general anaesthesia.

Published
1997
Full Text
View/download PDF

31. Prevention of spinal anesthesia-induced hypotension in the elderly: comparison between preanesthetic administration of crystalloids, colloids, and no prehydration.

Author

Buggy D, Higgins P, Moran C, O'Brien D, O'Donovan F, and McCarroll M

Subjects
Aged, Aged, 80 and over, Blood Pressure, Crystalloid Solutions, Double-Blind Method, Ephedrine therapeutic use, Female, Humans, Hypotension drug therapy, Hypotension etiology, Isotonic Solutions therapeutic use, Male, Middle Aged, Polygeline administration & dosage, Ringer's Lactate, Anesthesia, Spinal adverse effects, Colloids administration & dosage, Hypotension prevention & control, Plasma Substitutes administration & dosage, Preoperative Care
Abstract

The practice of routinely prehydrating patients by infusing a crystalloid or colloid solution (up to 1.0 L/70 kg) for prevention of spinal anesthesia-induced hypotension has been challenged recently, after several reports of failure to demonstrate its efficacy in young women. We compared the incidence and frequency of hypotension and vasopressor therapy after spinal anesthesia and no prehydration with crystalloid and colloid prehydration in elderly patients. Eighty-five ASA grade I or II patients (aged 60-89 yr) for elective total hip replacement were randomized to receive 500 mL crystalloid solution (Hartmanns, n = 29), 500 mL colloid (Haemaccel, n = 28), or no prehydration (n = 28) over 10 min prior to spinal anesthesia. Hypotension was defined as a 30% decrease from baseline systolic blood pressure (BP) or systolic < 90 mm Hg, and was treated with ephedrine 3-mg boluses. Although absolute systolic BP readings were significantly higher in the colloid group between 6 and 30 min (P < 0.05), the incidence of hypotension was not significantly different between the groups. The incidence of ephedrine use, incidence of nausea/vomiting, and median total dose of ephedrine were similar in all groups. We conclude that, in elderly patients undergoing elective procedures, withholding prehydration is not associated with any greater degree of hypotension or need for vasopressor therapy compared with crystalloid or colloid prehydration.

Published
1997
Full Text
View/download PDF

32. Emergency sleeve lobectomy after blunt chest trauma in a child.

Author

McCarthy JF, Claffey LP, O'Donovan F, Guiney EJ, and Luke DA

Subjects
Accidents, Traffic, Adult, Humans, Male, Pneumonectomy methods, Respiration, Artificial, Thoracic Injuries therapy, Wounds, Nonpenetrating therapy, Bronchi injuries, Bronchi surgery, Lung surgery, Lung Injury, Thoracic Injuries surgery, Wounds, Nonpenetrating surgery
Abstract

The clinical features and successful management of a patient with right main bronchus disruption after blunt chest trauma are described. The presentation was one of bilateral tension pneumothoraces. A high index of suspicion, coupled with appropriate airway management at presentation, was vital for the successful treatment of this patient. Surgical resection using a sleeve lobectomy, an operation rarely used in trauma patients, was highly effective in this patient, and the technique is described in this report.

Published
1996
Full Text
View/download PDF

33. Per-urethral transvesical first-trimester amniocentesis.

Author

Frydman R, Pons JC, Borghi E, Selva J, Olivennes F, O'Donovan F, Fernandez H, and Le Lorc'h M

Subjects
Female, Humans, Pregnancy, Pregnancy Trimester, First, Urethra, Urinary Bladder, Amniocentesis methods
Abstract

Early amniocentesis (before 13 weeks' gestation) using a per-urethral transvesical route is studied. Eight samples were obtained in eight patients scheduled for elective termination of pregnancy. The volume of amniotic fluid averaged 12.5 +/- 7.8 ml. Culture was successful in all samples. In one case, culture was achieved with only 2 ml of amniotic fluid. The amniotic fluid can be easily obtained via the per-urethral transvesical route. We conclude that early per-urethral amniocentesis before 13 weeks amenorrhea may be an alternative to the transabdominal route. A clinical trial should be carried out in order to evaluate both techniques.

Published
1993
Full Text
View/download PDF

34. [Criteria of recovery from caudal anesthesia in children].

Author

Saint-Raymond S, O'Donovan F, and Ecoffey C

Subjects
Child, Child, Preschool, Halothane, Humans, Infant, Nitrous Oxide, Ambulatory Surgical Procedures, Analgesia, Epidural, Anesthesia Recovery Period, Anesthesia, Inhalation, Bupivacaine, Pain, Postoperative prevention & control
Abstract

The authors evaluated the return of sensory, motor, and sympathetic nervous system function following caudal block in children. Twenty children, ASA PS I, aged 5 +/- 4 yr (mean +/- SD), weighing 22 +/- 9 kg, scheduled for lower abdominal and urologic surgical procedures were studied. Anaesthesia was induced and maintained by halothane, N2O and oxygen. A caudal block was performed with 1 ml/kg of 0.25% bupivacaine. Analgesia assessed by Broadman's score was efficient in 18 out of the 20 children during the first 4 hours after the block. Upper level of cutaneous analgesia was T10 +/- 2 after the block. Two hours after the caudal injection an incomplete motor blockade was found in 14 of 20 children, and at 4 hours no block was found in any child. Heart rate was significantly increased in the upright position (122 +/- 12 to 131 +/- 26 bpm at 2 hours, and 110 +/- 21 to 118 +/- 28 bpm at 4 hours), whereas arterial blood pressure was unchanged in the upright position.

Published
1990

35. [Sports and pregnancy. A review of the literature].

Author

Fierobe T, Pons JC, Edouard D, O'Donovan F, and Papiernik E

Subjects
Female, Fetus physiology, Humans, Pregnancy Outcome, Pregnancy physiology, Sports
Abstract

A review of the literature concerning sport during pregnancy is presented. The mother's heart rate, arterial blood pressure, systolic ejection fraction and cardiac output undergo the same changes during exercise in the pregnant and non-pregnant patient. The increase in the fetal heart rate during maternal physical exercise does not adversely affect the fetal outcome. The uterine blood flow is diminished during exercise. The respiratory rate increases equally in pregnant and non-pregnant women. The maternal response to effort is also modified by weight gain during pregnancy, by changes in the musculo-skeletal system, and by maternal temperature control during exercise. Weight gain, uterine contractility, duration of pregnancy, labour and neo-natal conditions are not altered by sport during pregnancy. Contra-indications to sport during pregnancy include threatened premature labour, and conditions associated with an increased risk of prematurity. A previous history of fetal growth retardation, acute fetal distress, or the presence of diabetes or arterial hypertension is a contra-indication to sport during pregnancy. The advice which should be given to a pregnant woman wishing to continue her sporting activities during pregnancy is outlined.

Published
1990

37. [Ambulatory monitoring and telephone transmission of uterine activity. Preliminary study on the evaluation of the TOKOS system].

Author

Pons JC, Chave C, Benifla JL, Diochin P, O'Donovan F, and Papiernik E

Subjects
Adult, Evaluation Studies as Topic, Female, Humans, Monitoring, Physiologic instrumentation, Pregnancy, Reference Values, Modems, Monitoring, Physiologic methods, Telephone, Uterine Contraction
Abstract

The authors compare 100 tracings of uterine contractions, recorded using a mobile monitoring apparatus with telephone output TOKOS System), with 100 tracings recorded using static equipment. The TOKOS system is useful in diagnosis of uterine contraction, being equivalent to the reference system. The TOKOS system is superior to the reference system in that it allows the intensity of the contractions to be evaluated. The TOKOS system is an original approach to maternal perception of uterine activity. Overall, 28% of contractions are identified by the patient. The authors conclude that the tracings produced by the TOKOS system are more reliable than maternal perception of uterine contractions.

Published
1988

Catalog

Books, media, physical & digital resources
See catalog results