1. International HTA Experience with Targeted Therapy Approvals for Lung Cancer
- Author
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F Maraiki, Joshua Byrnes, Haitham Tuffaha, and M Hider
- Subjects
Oncology ,medicine.medical_specialty ,Cost effectiveness ,medicine.medical_treatment ,education ,MEDLINE ,Targeted therapy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Environmental health ,Medicine ,Pharmacology (medical) ,Original Research Article ,030212 general & internal medicine ,Limited evidence ,Lung cancer ,Pharmacology ,Health economics ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Health technology ,medicine.disease ,030220 oncology & carcinogenesis ,Listing (finance) ,business - Abstract
Objectives The aim of this study was to compare the listing success rates and time incurred to listing of recently approved lung cancer medications across Australia, Canada and England. Methods A comparison between the three countries was performed with respect to the listing status, time incurred for listing and differences in recommendations made for cost effectiveness. Major uncertainties and limitations that compromise health technology assessment (HTA) recommendations were identified. Results The listing success rate was found to be low across all three countries (33% Canada, 17% England and 8% Australia). Across the HTA agencies’ reviews, comparators were either dissimilar or altered for effectiveness and/or economic analysis. Overall, limited evidence was found for all indications, and uncertainties were identified due to indirect analyses (70%) and survival extrapolation (100%). Although most of the indications were concluded to be not cost effective, some were subsequently listed (47%) at a reduced price and/or with a specific access programme. Conclusions This study demonstrated a low listing success rate for novel lung therapies internationally within different HTA jurisdictions. Major uncertainties that are resistant to available solutions seem to be common across different countries; thus, international solutions would be beneficial
- Published
- 2018