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16 results on '"F. J. van de Vaart"'

1. Particulate matter determination in LVPs produced in Dutch hospital pharmacies. Part 2: Overview of the results

Author

F A, Boom, J, Van der Veen, P, Verbrugge, F J, Van de Vaart, A C, Paalman, and T, Vos

Subjects
Pharmacies, Solutions, Pharmaceutical Solutions, Infusions, Parenteral, Particle Size, Drug Contamination, Pharmacy Service, Hospital, Netherlands
Abstract

The Laboratory of Dutch Pharmacists determines LVP particulate matter contamination of LVPs produced in Dutch hospital pharmacies. The investigated LVPs must conform to the NVZA/LNA criteria, which prescribes eight samples and sets limits for particlesor = 2 microns,or = 5 microns,or = 10 microns, andor = 25 microns for both mean and mean + 2x standard deviation. LVPs produced in 500 mL glass containers or plastic containers mostly met the NVZA/LNA criteria, but LVPs produced in 100 mL glass containers showed higher levels of particulate matter contamination. The composition of the LVP significantly affected the extent of particulate matter contamination, but the effect was relatively small when compared to the influence of the type of container. LVPs produced in Dutch hospital pharmacies and LVPs obtained from pharmaceutical industries showed comparable amounts of particulate matter contamination.

Published
2000

2. Particulate matter determination in LVPs produced in Dutch hospital pharmacies, Part 1: Particle-counting accuracy

Author

J, Van der Veen, P, Verbrugge, F J, Van de Vaart, and F A, Boom

Subjects
Quality Control, Solutions, Latex, Suspensions, Calibration, Reproducibility of Results, Sterilization, Infusions, Parenteral, Particle Size, Drug Contamination, Pharmacy Service, Hospital, Therapeutic Irrigation, Netherlands
Abstract

Reproducible particle counting using the light-obscuration technique is often troublesome because no absolute standard is available. Therefore, at the Laboratory of Dutch Pharmacists the "calibration-in-time" method was developed. This method enables checking of the amount of particles counted from a diluted latex suspension as a function of time. A particularity of the method is the one-step dilution procedure. The calibration-in-time method is compared with the particle-counting accuracy test according to the USP788. Advantages and disadvantages of both methods are discussed.

Published
1997

3. The analysis of creams; a critical review

Author

A. W. M. Indemans, A. Hulshoff, and F. J. Van De Vaart

Subjects
Pharmacology, medicine.medical_specialty, business.industry, Family medicine, digestive, oral, and skin physiology, food and beverages, Medicine, Pharmacology (medical), Pharmacy, skin and connective tissue diseases, business
Abstract

Qualitative and quantitative procedures for the analysis of creams of the oil-in-water type are reviewed and discussed, with special attention to the clean-up methods. It is concluded that systematic investigations have hardly been reported, except for creams containing corticosteroids.

Published
1980

4. The application of chromatography to the analysis of pharmaceutical creams

Author

A. Hulshoff, O. A. Lake, A. W. M. Indemans, and F. J. Van De Vaart

Subjects
Chromatography, organic chemicals, Chloramphenicol, Organic Chemistry, Clinical Biochemistry, Reversed-phase chromatography, Biochemistry, High-performance liquid chromatography, Thin-layer chromatography, Analytical Chemistry, chemistry.chemical_compound, chemistry, medicine, Stilbestrol, Gas chromatography, Salicylic acid, medicine.drug, Benzoic acid
Abstract

The application of GLC, HPLC and TLC to the analysis of pharmaceutical creams is discussed with special attention to sample clean-up. The results of the determination of hydrocortisone acetate, salicylic acid, benzoic acid, diethyl stilbestrol, chloramphenicol, diphenhydramine HCl, tretinoin and some cream base components by reversed phase HPLC are given.

Published
1982

5. Analysis of creams

Author

A. Hulshoff, A. W. M. Indemans, and F. J. Van De Vaart

Subjects
Pharmacology, Perchlorates, Aqueous solution, Chromatography, Organic base, Tetrabutylammonium hydroxide, Halide, Ointments, Quaternary Ammonium Compounds, Acetic acid, chemistry.chemical_compound, Pharmaceutical Preparations, chemistry, Potentiometry, Solvents, Pharmacology (medical), Titration, Perchloric acid, Salicylic acid
Abstract

The possibilities for the determination of active components in creams by acid-base titrations in non-aqueous solvents were investigated. Interference by cream-base components with the titration of weak organic bases and their halides with perchloric acid in acetic acid, and with the titration of weak acids with tetrabutylammonium hydroxide in N,N-dimethylformamide were studied. It appeared to be possible to determine alkaloid halides, salicylic acid, hexachlorophene and methyl salicylate without previous clean-up of the cream samples.

Published
1982

6. Abstracts of papers Pharmaceutical and biomedical analysis meeting

Author

R. Both-Miedema, E. H. J. M. Jansen, H. A. Claessens, P. J. M. Hendriks, M. T. Ackermans, R. W. Sparidans, F. M. Everaerts, G. de Groot, R. Koops, K. L. Wubs, J. de Jong, S. F. Cheung, P. A. Maessen, H. M. Pinedo, W. J. F. van der Vijgh, J. den Hartigh, R. Langebroek, P. Vermeij, L. Doom, F. X. R. van Leeuwen, C. E. M. Heeremans, R. A. M. van der Hoeven, W. M. A. Niessen, U. R. Tjaden, J. van der Greef, J. Hempenius, B. Staal, H. J. Jeuring, C. K. Mensink, J. H. G. Jonkman, H. Hindriks, F. Maris, A. Pasters, M. de Smet, D. Massart, P. S. L. Janssen, R. L. A. E. Hamelinck, P. A. T. A. Melgers, J. W. van Nispen, M. J. M. van Zeeland, M. H. J. M. van de Ven, J. Vink, H. Lambrechts, G. Pattyn, A. T. Van Oosterom, E. A. de Bruijn, O. R. Leeuwenkamp, R. Barto, H. Greuter, P. Lips, J. C. Netelenbos, F. A. Maris, R. J. M. Vervoort, M. B. Vrieling, E. J. M. Reinerink, R. H. van den Berg, E. Roets, L. Aerden, I. Hoogmartens, S. V. Rose, J. P. Crombeen, L. G. D. Lammerts van Bueren, H. Rosing, F. Elferink, F. J. van de Vaart, A. C. Schoots, P. H. J. M. De Vries, T. P. E. M. Verheggen, O. M. Steijger, E. Hoksbergen, R. A. Baumann, J. J. M. Holthuis, U. A. Th. Brinkman, B. Takkenberg, H. E. van Ingen, M. Ackermans, E. Endert, UR Tjaden, HJEM Reeuwijk, A. T. van Oosterom, C. van de Water, N. Haagsma, W. A. van den Ham, A. H. Piersma, L. A. van Ginkel, R. W. Stephany, J. C. M. Farla, H. J. van Rossum, R. van Gijn, J. H. Beijnen, J. J. M. de Clippeleir, S. Horenblas, W. J. M. Underberg, O. van Tellingen, J. H. Beilnen, H. R. van der Woude, W. J. Nooven, K. van Twillert, P. W. M. Zeijlmans, M. Olling, H. G. J. M. Derks, Weng Naidong, Th. Cachet, J. Hoogmartens, J. Wieling, P. M. J. Coencgracht, D. A. Doornbos, and G. Windhorst

Subjects
Pharmacology, medicine.medical_specialty, Medical education, business.industry, Political science, Public health, medicine, Pharmacology (medical), Pharmacy, business
Published
1989

7. Analysis of creams

Author

A. W. M. Indemans, F. J. Van De Vaart, and A. Hulshoff

Subjects
Pharmacology, Chromatography, Chemistry, Pharmacology (medical), Quantitative determination, Uv spectrophotometry
Published
1980

8. Boekbesprekingen

Author

J. R. B. J. Brouwers, A. C. Van Loenen, L. O. M. J. Smithuis, J. H. G. Jonkman, F. J. Van De Vaart, P. J. J. De Meijer, and J. W. Weyland

Subjects
Pharmacology, Pharmacology (medical)
Published
1981

9. Analysis of creams

Author

A. W. M. Indemans, F. J. Van De Vaart, A. Hulshoff, and O. A. Lake

Subjects
Pharmacology, Solvent, chemistry.chemical_compound, Chromatography, Column chromatography, chemistry, Ionic strength, Phase (matter), Emulsion, Pharmacology (medical), Methanol, Sorbic acid, High-performance liquid chromatography
Abstract

The possibilities of applying reversed-phase high performance liquid chromatography to the analysis of o/w emulsion type creams without preceding sample clean-up were investigated. The chromatographic behaviour of cream base components and active compounds in reversed phase systems consisting of methanol-water mixtures as the mobile phase and a chemically bonded octadecyl stationary phase, was studied. A number of active compounds and the preservative (sorbic acid) could be determined--often in one chromatographic run--without complications, by simply dissolving the sample in a suitable solvent mixture and injecting an aliquot of the solution into the chromatograph. Separation was achieved by the proper choice of methanol content, pH and ionic strength of the eluent. The compounds were detected by UV absorption. Some of the lipophilic cream base components could easily be determined in the same manner, with methanol as the eluent and with refraction index detection. The developed procedure was applied to the analysis of a number of creams. Some of the results are presented as examples, demonstrating the suitability of the method for quality control purposes.

Published
1983

10. Abstracts of papers

Author

W. E. Roorda, M. A. de Vries, C. Kosho, J. A. Bouwstra, H. E. Junginger, H. E. Boddé, C. Kleinjan, W. C. de Bruyn, W. T. Daems, T. Kranenburg, L. M. J. van Driel, R. Roosjen, H. F. L. Gulot, T. de Vringer, J. G. H. Joosten, H. Jousma, J. Bouwstra, G. Gooris, G. S. Gooris, H. L. G. M. Tiemessen, H. E. Junsinger, J. Verhoeven, J. J. H. U. de Groot, R. J. Schaeffer, L. J. C. Peschier, G. S. M. J. E. Duchateau, J. Zuldema, F. W. H. M. Merkus, F. A. J. M. Pieters, D. Dekker, L. van Blools, D. J. A. Crommelin, W. Jiskoot, J. C. A. Offringa, R. Plekkenpol, P. A. M. Peeters, A. C. M. Claessens, P. W. J. T. Leufkens, W. M. C. Eling, F. G. J. Poelma, J. J. Tukker, D. J. A. Cromnelin, G. Storm, L. van Bloois, M. Brouwer, H. Talsma, M. A. Blankenstein, J. W. R. Nortier, A. Bakri, J. Wilting, L. H. H. Janssen, P. J. A. Crommelin, A. M. Mathieu, M. van Ooteghem, A. Ludwig, D. D. Breimer, A. G. de Boer, C. H. Kleinbloesem, P. van Brummelen, M. Danhof, J. Urquhart, G. K. Bolhuis, H. V. van Kamp, J. H. Proost, C. F. Lerk, A. H. de Boer, H. Vromans, P. de Haan, A. J. M. Schoonen, G. W. de Vries-Nijboer, E. H. Bosch, K. D. Kussendrager, H. K. F. van Saene, H. F. Mahieu, J. J. M. van Saene, L. Baaijens, E. Middelbeek, R. van Rooy, M. J. C. Vissers, L. Baaljens, A. P. Sam, Y. Boer, D. Janknegt, H. L. M. Cox, P. J. J. de Meijer, P. H. A. M. Kloeg, C. K. Mensink, F. J. van de Vaart, W. Roggen, F. A. Boom, A. C. A. Paalman, Th. Vos, J. J. de Gier, A. Takken-Hillebrecht, J. A. L. van Lakwijk-Najoan, H. G. M. Leufkens, and A. H. P. Paes

Subjects
Pharmacology, Pharmacology (medical)
Published
1986

11. Abstracts of papers

Author

W. J. van Oort, B. Kerkhofs, A. van Dijk, O. A. G. J. van der Houwen, A. Hulshoff, A. W. M. Indemans, J. C. Reijenga, A. Gaykema, F. E. P. Mikkers, O. R. Leeuwenkamp, H. Jousma, E. J. van der Mark, A. Bult, W. van Iersel, B. F. H. Drenth, R. T. Ghijsen, R. A. de Zeeuw, J. J. M. Holthuis, A. W. Sijstermans, F. M. G. M. Römkens, E. B. C. M. Weller, H. M. Pinedo, J. G. McVie, P. M. Barends, M. H. Smits, J. S. Blauw, J. den Hartigh, R. J. Driebergen, J. E. M. A. Schijns, W. J. M. Underberg, O. A. Lake, H. Lingeman, U. K. Underberg-Chitoe, J. Wilting, T. Jagersma, J. C. Hoogvliet, F. Elferink, A. C. J. Hermans-Lokkerbol, W. P. van Bennekom, C. E. Werkhoven-Goewie, C. de Ruiter, U. A. Th. Brinkman, R. W. Frei, G. de Vries, J. F. van de Calseyde, J. van der Veeken, Th. P. E. M. Verheggen, F. M. Everaerts, W. J. F. van der Vijgh, H. B. J. van der Lee, G. J. Postma, Tom B. Vree, Chiel A. Hekster, Marijn M. J. Oosterbaan, Emiel F. S. Termond, A. C. Schoots, C. A. Cramers, H. Poppe, F. J. van de Vaart, H. A. Claessens, M. van Thiel, P. Westra, J. J. M. Labout, and A. P. Bruins

Subjects
Pharmacology, Pharmacology (medical)
Published
1982

12. Separation of some fatty ointment excipients by gradient elution HPTLC

Author

F. J. Van De Vaart

Subjects
Pharmacology, Chromatography, Chemistry, Gradient elution, Pharmacology (medical)
Abstract

A very simple gradient elutionTlc system for the separation of some common fatty excipients of rather varying polarities in one run is presented. WhenHptlc precoated plates are used, run times are as short as 10 minutes. The system is useful as a simple quality control for fatty excipients, ointment bases and complete ointments. Een eenvoudig dunnelaag-chromatografisch systeem met gradient-elutie voor de bepaling van enkele veel gebruikte vette hulpstoffen wordt beschreven. MetHptlc precoated plates kunnen Stoffen van uiteenlopende polariteit in een gang, binnen 10 minuten, worden gescheiden. Het systeem is bruikbaar voor eenvoudige kwaliteitscontrole van vette excipienten, zalfbases en zalven.

Published
1981

13. Abstracts of papers Pharmaceutical and biomedical analysis meeting

Author

A. U. Bandhoe, A. C. A. Paalman, W. J. M. Underberg, J. H. Beijnen, O. Bekers, M. Otagiri, A. Bult, Gert Beuman, Jacques van der Heijden, Jenny Janss, P. R. J. Ceelen, G. G. L. M. Feenstra-Bielders, D. J. Groeneveld, D. de Boer, M. J. A. Rutten, E. G. de Jong, R. A. A. Maes, J. M. van Rossum, G. de Groot, R. Kopps, T. J. F. Savelkoul, P. van Vloten, E. G. de Jonag, R. van Ooyen, J. Kiffers, I. F. I. de Kroon, P. N. J. Langendijk, P. N. F. C. de Goede, M. De Smet, C. Musch, A. Peeters, L. Buydens, D. L. Massart, K. De Turck, Th. Cachet, J. Hoogmartens, M. Delrue, P. Lannoo, B. F. H. Drenth, F. J. Beckeringh, J. Bosman, K. G. Feitsma, A. van Nijhuisvan Dam, R. J. Driebergen, J. A. van Gorp, K. Ensing, A. Farlam, G. J. de Jong, R. W. Frel, U. A. Th. Brinkman, T. K. Gerding, V. J. M. van de Grampel, N. R. Niemeijer, R. A. de Zeeuw, P. G. Tepper, A. S. Horn, J. J. Halvax, G. Wiese, W. P. van Bennekom, Rik Hindriks, Lutgarde Buydens, Anne Peeters, Marina de Smet, Luc Massart, Aric Blokland, Jan Vink, S. Keizers, W. M. A. Niessen, E. R. Verhey, G. F. LaVos, U. R. Tjaden, J. van der Greef, J. A. Ooms, G. S. J. Haak, G. Grooten, G. Pattyn, P. Sandra, F. David, A. T. van Oosterom, E. A. de Bruijn, A. V. Pouwelse, D. de Jong, N. G. F. M. Lammers, J. H. M. van den Berg, I. Quintens, E. Roets, H. J. E. M. Reeuwijk, H. Lingeman, H. J. Keizer, H. Rosing, F. Elferink, F. J. van de Vaart, P. H. A. M. Kloeg, André Sauter, D. S. Stegehuis, N. J. Reinhoud, O. M. Steijger, J. J. L. Hilhorst, J. J. M. Holthuis, U. K. Underberg-Chitoe, P. L. Meenhorst, G. Van den Mooter, R. Hauchecorne, C. Vinckier, A. van der Horst, H. J. M. Martens, F. A. L. van der Horst, M. H. Post, L. A. van Ginkel, P. W. Zoontjes, H. van Blitterswijk, R. W. Stephany, R. van Gijn, C. H. Bakker, C. H. W. Koks, S. Rodenhuis, M. A. J. van Opstal, F. A. L. van den Horst, P. Krabbenborg, O. van Tellingen, H. R. v. d. Woude, C. J. T. van Beers, W. J. Nooyen, F. J. Varossieau, G. Los, J. D. Nagel, J. G. McVie, R. N. Veen, J. T. Op 't Land, D. E. M. M. Vendrig, J. Teeuwsen, F. C. A. M. Verlaar, T. J. H. M. Trum, J. P. de Kleijn, R. Vervoort, M. Vrieling, F. Maris, H. Hindriks, A. Walhagen, L. -E. Edholm, C. E. M. Heeremans, and R. A. M. van der Hoeven

Subjects
Pharmacology, Pharmacology (medical)
Published
1989

14. Analysis of creams

Author

A. Hulshoff, F. J. Van De Vaart, and A. W. M. Indemans

Subjects
Pharmacology, Chromatography, Chemistry, Cream base, Thin-layer chromatography, Standard procedure, Excipients, chemistry.chemical_compound, Column chromatography, Gradient elution, Emulsions, Pharmacology (medical), Chromatography, Thin Layer, Diethyl ether
Abstract

A standard procedure, consisting of two TLC systems, for the qualitative control of creams is presented. All common cream excipients, except those of very high polarity, are separated in a simple gradient elution system, using diethyl ether as the eluent in a chromatographic chamber saturated with n-pentane. The very polar cream base components are separated using n-butanol-glacial acetic acid-water (20 + 2 + 5) as the eluent. The chromatographic behaviour of common cream excipients as well as three FNA cream bases and four commercial cream bases is discussed.

Published
1983

15. Analysis of creams. IV. Application of high performance liquid chromatography. Part I

Author

O A, Lake, A, Hulshoff, F J, Van De Vaart, and A W, Indemans

Subjects
Ointments, Adrenal Cortex Hormones, Chromatography, High Pressure Liquid
Abstract

The possibilities of applying reversed-phase high performance liquid chromatography to the analysis of o/w emulsion type creams without preceding sample clean-up were investigated. The chromatographic behaviour of cream base components and active compounds in reversed phase systems consisting of methanol-water mixtures as the mobile phase and a chemically bonded octadecyl stationary phase, was studied. A number of active compounds and the preservative (sorbic acid) could be determined--often in one chromatographic run--without complications, by simply dissolving the sample in a suitable solvent mixture and injecting an aliquot of the solution into the chromatograph. Separation was achieved by the proper choice of methanol content, pH and ionic strength of the eluent. The compounds were detected by UV absorption. Some of the lipophilic cream base components could easily be determined in the same manner, with methanol as the eluent and with refraction index detection. The developed procedure was applied to the analysis of a number of creams. Some of the results are presented as examples, demonstrating the suitability of the method for quality control purposes.

Published
1983

16. Analysis of creams. V. Application of thin layer chromatography. Part II

Author

F. J. Van De Vaart, A. Hulshoff, and A. W. M. Indemans

Subjects
Pharmacology, Excipients, Qualitative analysis, Chromatography, Chemistry, Adrenal Cortex Hormones, Cream base, Reagent, Extraction (chemistry), Pharmacology (medical), Emulsions, Chromatography, Thin Layer, Standard procedure
Abstract

A standard TLC procedure was tested for its applicability in the qualitative analysis of several creams. It was found that in creams of known composition the presence of almost all of the active cream components as well as the excipients can be confirmed. An additional eluent, spray reagent, or a liquid extraction clean-up step sometimes appeared to be necessary. If the cream base composition is not known, a 'fingerprint' of the various types of excipients is obtained with the described procedure.

Published
1983

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