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1. The ASTRI Mini-Array of Cherenkov Telescopes at the Observatorio del Teide

Author: S., Scuderi, A., Giuliani, G., Pareschi, G., Tosti, O., Catalano, E., Amato, A., Antonelli L., J., Becerra Gonzáles, G., Bellassai, Bigongiari, B., Biondo, M., Böttcher, G., Bonanno, G., Bonnoli, P., Bruno, A., Bulgarelli, R., Canestrari, M., Capalbi, P., Caraveo, M., Cardillo, V., Conforti, G., Contino, M., Corpora, A., Costa, G., Cusumano, A., D'Aí, E., de Gouveia Dal Pino, R., Della Ceca, D., Escribano Rodriguez E. Falceta Gonçalves, C., Fermino, M., Fiori, V., Fioretti, M., Fiorini, S., Gallozzi, C., Gargano, S., Garozzo, S., Germani, A., Ghedina, F., Gianotti, S., Giarrusso, R., Gimenes, V., Giordano, A., Grillo, C., Grivel Gelly, D., Impiombato, F., Incardona, S., Incorvaia, S., Iovenitti, A., La Barbera, N., La Palombara, V., La Parola, A., Lamastra, L., Lessio, G., Leto, F., Lo Gerfo, M., Lodi, S., Lombardi, F., Longo, F., Lucarelli, C., Maccarone M., D., Marano, E., Martinetti, S., Mereghetti, A., Micciché, R., Millul, T., Mineo, D., Mollica, G., Morlino, A., Morselli, G., Naletto, G., Nicotra, A., Pagliaro, N., Parmiggiani, G., Piano, F., Pintore, E., Poretti, B., Olmi, G., Rodeghiero, G., Rodriguez Fernandez, P., Romano, G., Romeo, F., Russo, P., Sangiorgi, G., Saturni F., H., Schwarz J., Sciacca, G., Sironi, G., Sottile, A., Stamerra, G., Tagliaferri, V., Testa, G., Umana, M., Uslenghi, S., Vercellone, L., Zampieri, and R, Zanmar Sanchez
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The ASTRI Mini-Array (MA) is an INAF project to build and operate a facility to study astronomical sources emitting at very high-energy in the TeV spectral band. The ASTRI MA consists of a group of nine innovative Imaging Atmospheric Cherenkov telescopes. The telescopes will be installed at the Teide Astronomical Observatory of the Instituto de Astrofisica de Canarias (IAC) in Tenerife (Canary Islands, Spain) on the basis of a host agreement with INAF. Thanks to its expected overall performance, better than those of current Cherenkov telescopes' arrays for energies above \sim 5 TeV and up to 100 TeV and beyond, the ASTRI MA will represent an important instrument to perform deep observations of the Galactic and extra-Galactic sky at these energies., Comment: 19 pages, 22 figures
Published: 2022
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2. Extragalactic observatory science with the ASTRI mini-array at the Observatorio del Teide

Author: F.G. Saturni, C.H.E. Arcaro, B. Balmaverde, J. Becerra González, A. Caccianiga, M. Capalbi, A. Lamastra, S. Lombardi, F. Lucarelli, R. Alves Batista, L.A. Antonelli, E.M. de Gouveia Dal Pino, R. Della Ceca, J.G. Green, A. Pagliaro, C. Righi, F. Tavecchio, S. Vercellone, A. Wolter, E. Amato, C. Bigongiari, M. Böttcher, G. Brunetti, P. Bruno, A. Bulgarelli, M. Cardillo, V. Conforti, A. Costa, G. Cusumano, V. Fioretti, S. Germani, A. Ghedina, F. Gianotti, V. Giordano, A. Giuliani, F. Incardona, A. La Barbera, G. Leto, F. Longo, G. Morlino, B. Olmi, N. Parmiggiani, P. Romano, G. Romeo, A. Stamerra, G. Tagliaferri, V. Testa, G. Tosti, P.A. Caraveo, and G. Pareschi
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Space and Planetary Science, Gamma ray, FOS: Physical sciences, Cherenkov, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, ASTRI Mini Array, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov, Extragalactic, Gamma ray, ASTRI Mini Array, Extragalactic
Abstract: The ASTRI Mini-Array is a next-generation system of nine imaging atmospheric Cherenkov telescopes that is going to be built at the Observatorio del Teide site. After a first phase, in which the instrument will be operated as an experiment prioritizing a schedule of primary science cases, an observatory phase is foreseen in which other significant targets will be pointed. We focus on the observational feasibility of extragalactic sources and on astrophysical processes that best complement and expand the ASTRI Mini-Array core science, presenting the most relevant examples that are at reach of detection over long-term time scales and whose observation can provide breakthrough achievements in the very-high energy extragalactic science. Such examples cover a wide range of $\gamma$-ray emitters, including the study of AGN low states in the multi-TeV energy range, the possible detection of Seyfert galaxies with long exposures and the searches of dark matter lines above 10 TeV. Simulations of the presented objects show that the instrument performance will be competitive at multi-TeV energies with respect to current arrays of Cherenkov telescopes., Comment: 27 pages, 10 figures, 7 tables, published on JHEAp
Published: 2022

3. Sensitivity of the Cherenkov Telescope Array to TeV photon emission from the Large Magellanic Cloud

Author: A Acharyya, R Adam, A Aguasca-Cabot, I Agudo, A Aguirre-Santaella, J Alfaro, R Aloisio, R Alves Batista, E Amato, E O Angüner, C Aramo, C Arcaro, K Asano, J Aschersleben, H Ashkar, M Backes, A Baktash, C Balazs, M Balbo, J Ballet, A Bamba, A Baquero Larriva, V Barbosa Martins, U Barres de Almeida, J A Barrio, D Bastieri, P Batista, I Batkovic, J R Baxter, J Becerra González, J Becker Tjus, W Benbow, E Bernardini, M I Bernardos Martín, J Bernete Medrano, A Berti, B Bertucci, V Beshley, P Bhattacharjee, S Bhattacharyya, C Bigongiari, A Biland, E Bissaldi, F Bocchino, P Bordas, J Borkowski, E Bottacini, M Böttcher, F Bradascio, A M Brown, A Bulgarelli, L Burmistrov, S Caroff, A Carosi, E Carquín, S Casanova, E Cascone, F Cassol, M Cerruti, P Chadwick, S Chaty, A Chen, A Chiavassa, L Chytka, V Conforti, J Cortina, A Costa, H Costantini, G Cotter, S Crestan, P Cristofari, F D’Ammando, M Dalchenko, F Dazzi, A De Angelis, V De Caprio, E M de Gouveia Dal Pino, D De Martino, M de Naurois, V de Souza, M V del Valle, A G Delgado Giler, C Delgado, D della Volpe, D Depaoli, T Di Girolamo, A Di Piano, F Di Pierro, R Di Tria, L Di Venere, S Diebold, M Doro, D Dumora, V V Dwarkadas, C Eckner, K Egberts, G Emery, J Escudero, D Falceta-Goncalves, E Fedorova, S Fegan, Q Feng, D Ferenc, G Ferrand, E Fiandrini, M Filipovic, V Fioretti, L Foffano, G Fontaine, Y Fukui, D Gaggero, G Galanti, G Galaz, S Gallozzi, V Gammaldi, M Garczarczyk, C Gasbarra, D Gasparrini, A Ghalumyan, M Giarrusso, G Giavitto, N Giglietto, F Giordano, A Giuliani, J-F Glicenstein, P Goldoni, J Goulart Coelho, J Granot, D Green, J G Green, M-H Grondin, O Gueta, D Hadasch, P Hamal, T Hassan, K Hayashi, M Heller, S Hernández Cadena, N Hiroshima, B Hnatyk, R Hnatyk, W Hofmann, J Holder, M Holler, D Horan, P Horvath, M Hrabovsky, M Hütten, M Iarlori, T Inada, F Incardona, S Inoue, F Iocco, M Jamrozy, W Jin, I Jung-Richardt, J Juryšek, D Kantzas, V Karas, H Katagiri, D Kerszberg, J Knödlseder, N Komin, P Kornecki, K Kosack, G Kowal, H Kubo, A Lamastra, J Lapington, M Lemoine-Goumard, J-P Lenain, F Leone, G Leto, F Leuschner, E Lindfors, T Lohse, S Lombardi, F Longo, R López-Coto, A López-Oramas, S Loporchio, P L Luque-Escamilla, O Macias, P Majumdar, D Mandat, S Mangano, G Manicò, M Mariotti, P Marquez, G Marsella, J Martí, P Martin, M Martínez, D Mazin, S Menchiari, D M-A Meyer, D Miceli, M Miceli, J Michałowski, A Mitchell, R Moderski, L Mohrmann, M Molero, E Molina, T Montaruli, A Moralejo, D Morcuende, A Morselli, E Moulin, V Moya, R Mukherjee, K Munari, A Muraczewski, S Nagataki, T Nakamori, A Nayak, J Niemiec, M Nievas, M Nikołajuk, K Nishijima, K Noda, D Nosek, B Novosyadlyj, S Nozaki, M Ohishi, S Ohm, A Okumura, B Olmi, R A Ong, M Orienti, R Orito, M Orlandini, E Orlando, S Orlando, M Ostrowski, I Oya, A Pagliaro, M Palatka, F R Pantaleo, R Paoletti, J M Paredes, N Parmiggiani, B Patricelli, M Pech, M Pecimotika, M Persic, O Petruk, E Pierre, E Pietropaolo, G Pirola, M Pohl, E Prandini, C Priyadarshi, G Pühlhofer, M L Pumo, M Punch, F S Queiroz, A Quirrenbach, S Rainò, R Rando, S Razzaque, A Reimer, O Reimer, T Reposeur, M Ribó, T Richtler, J Rico, F Rieger, M Rigoselli, V Rizi, E Roache, G Rodriguez Fernandez, P Romano, G Romeo, J Rosado, A Rosales de Leon, B Rudak, C Rulten, I Sadeh, T Saito, M Sánchez-Conde, H Sano, A Santangelo, R Santos-Lima, S Sarkar, F G Saturni, A Scherer, P Schovanek, F Schussler, U Schwanke, O Sergijenko, M Servillat, H Siejkowski, C Siqueira, S Spencer, A Stamerra, S Stanič, C Steppa, T Stolarczyk, Y Suda, T Tavernier, M Teshima, L Tibaldo, D F Torres, N Tothill, M Vacula, B Vallage, P Vallania, C van Eldik, M Vázquez Acosta, M Vecchi, S Ventura, S Vercellone, A Viana, C F Vigorito, J Vink, V Vitale, V Vodeb, S Vorobiov, T Vuillaume, S J Wagner, R Walter, M White, A Wierzcholska, M Will, R Yamazaki, L Yang, T Yoshikoshi, M Zacharias, G Zaharijas, D Zavrtanik, M Zavrtanik, A A Zdziarski, V I Zhdanov, K Ziętara, M Živec, Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Cherenkov Telescope Array
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), photon, emission, acceleration, efficiency, Cherenkov Telescope Array, WIMP, diffusion, FOS: Physical sciences, Astronomy and Astrophysics, suppression, sensitivity, Navarro-Frenk-White profile, dark matter, photon, energy, flux, cosmic radiation, spectrum, energy, high, Space and Planetary Science, cloud, TeV, spectral, galaxy, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], nucleus, cosmic radiation
Abstract: A deep survey of the Large Magellanic Cloud at ~0.1-100TeV photon energies with the Cherenkov Telescope Array is planned. We assess the detection prospects based on a model for the emission of the galaxy, comprising the four known TeV emitters, mock populations of sources, and interstellar emission on galactic scales. We also assess the detectability of 30 Doradus and SN 1987A, and the constraints that can be derived on the nature of dark matter. The survey will allow for fine spectral studies of N157B, N132D, LMC P3, and 30 Doradus C, and half a dozen other sources should be revealed, mainly pulsar-powered objects. The remnant from SN 1987A could be detected if it produces cosmic-ray nuclei with a flat power-law spectrum at high energies, or with a steeper index 2.3-2.4 pending a flux increase by a factor >3-4 over ~2015-2035. Large-scale interstellar emission remains mostly out of reach of the survey if its >10GeV spectrum has a soft photon index ~2.7, but degree-scale 0.1-10TeV pion-decay emission could be detected if the cosmic-ray spectrum hardens above >100GeV. The 30 Doradus star-forming region is detectable if acceleration efficiency is on the order of 1-10% of the mechanical luminosity and diffusion is suppressed by two orders of magnitude within, Accepted for publication in MNRAS. Corresponding authors: Pierrick Martin, Maria Isabel Bernardos Martin, Fabio Iocco
Published: 2023

4. QUBIC VII: The feedhorn-switch system of the technological demonstrator

Author: F. Cavaliere, A. Mennella, M. Zannoni, P. Battaglia, E. S. Battistelli, D. Burke, G. D’Alessandro, P. de Bernardis, M. De Petris, C. Franceschet, L. Grandsire, J. -Ch. Hamilton, B. Maffei, E. Manzan, S. Marnieros, S. Masi, C. O’Sullivan, A. Passerini, F. Pezzotta, M. Piat, A. Tartari, S. A. Torchinsky, D. Viganò, F. Voisin, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, B. Bélier, A. Baù, S. Banfi, D. Bennett, L. Bergé, J. -Ph. Bernard, M. Bersanelli, M. -A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Buzi, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, M. Gómez Berisso, M. M. Gamboa Lerena, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, E. Pagana, A. Paiella, F. Pajot, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, C. Scóccola, A. Schillaci, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J. -P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, N. Vittorio, F. Wicek, M. Wright, and A. Zullo, Cavaliere, F, Mennella, A, Zannoni, M, Battaglia, P, Battistelli, E, De Bernardis, P, Burke, D, D'Alessandro, G, De Petris, M, Franceschet, C, Grandsire, L, Hamilton, J, Maffei, B, Manzan, B, Marnieros, S, Masi, S, O'Sullivan, C, Passerini, A, Pezzotta, F, Piat, M, Tartari, A, Torchinsky, S, Viganò, D, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Pastoriza, H, Pelosi, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), QUBIC, D’Alessandro, G, de Bernardis, P, Manzan, E, O’Sullivan, C, Pagana, E, Perbost, C, Perciballi, M, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Vittorio, N, Wicek, F, Wright, M, and Zullo, A
Subjects: CMBR polarisation, Physics - Instrumentation and Detectors, Manchester Cancer Research Centre, Settore FIS/05, ResearchInstitutes_Networks_Beacons/mcrc, FOS: Physical sciences, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), CMBR detectors, CMBR experiments, gravitational waves and CMBR polarization, FIS/05 - ASTRONOMIA E ASTROFISICA, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], CMBR experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), CMBR detector
Abstract: We present the design, manufacturing and performance of the horn-switch system developed for the technological demonstrator of QUBIC (the $Q$\&$U$ Bolometric Interferometer for Cosmology). This system is constituted of 64 back-to-back dual-band (150\,GHz and 220\,GHz) corrugated feed-horns interspersed with mechanical switches used to select desired baselines during the instrument self-calibration. We manufactured the horns in aluminum platelets milled by photo-chemical etching and mechanically tightened with screws. The switches are based on steel blades that open and close the wave-guide between the back-to-back horns and are operated by miniaturized electromagnets. We also show the current development status of the feedhorn-switch system for the QUBIC full instrument, based on an array of 400 horn-switch assemblies., 30 pages, 28 figures. Accepted for submission to JCAP
Published: 2022

5. Cherenkov Telescope Array : the World’s largest VHE gamma-ray observatory

Author: Roberta Zanin, H. Abdalla, H. Abe, S. Abe, A. Abusleme, F. Acero, A. Acharyya, V. Acin Portella, K. Ackley, R. Adam, C. Adams, S.S. Adhikari, I. Aguado Ruesga, I. Agudo, R. Aguilera, A. Aguirre Santaella, F. Aharonian, A. Alberdi, R. Alfaro, J. Alfaro, C. Alispach, R. Aloisio, R. Alves Batista, J.P. Amans, L. Amati, E. Amato, L. Ambrogi, G. Ambrosi, M. Ambrosio, R. Ammendola, J. Anderson, M. Anduze, E.O. Anguner, L.A. Antonelli, V. Antonuccio, P. Antoranz, R. Anutarawiramkul, J. Aragunde Gutierrez, C. Aramo, A. Araudo, M. Araya, A. Arbet Engels, C. Arcaro, V. Arendt, C. Armand, T. Armstrong, F. Arqueros, L. Arrabito, B. Arsioli, M. Artero, K. Asano, Y. Ascasibar, J. Aschersleben, M. Ashley, P. Attina, P. Aubert, C. B. Singh, D. Baack, A. Babic, M. Backes, V. Baena, S. Bajtlik, A. Baktash, C. Balazs, M. Balbo, O. Ballester, J. Ballet, B. Balmaverde, A. Bamba, R. Bandiera, A. Baquero Larriva, P. Barai, C. Barbier, V. Barbosa Martins, M. Barcelo, M. Barkov, M. Barnard, L. Baroncelli, U. Barres de Almeida, J.A. Barrio, D. Bastieri, P.I. Batista, I. Batkovic, C. Bauer, R. Bautista González, J. Baxter, U. Becciani, J. Becerra González, Y. Becherini, G. Beck, J. Becker Tjus, W. Bednarek, A. Belfiore, L. Bellizzi, R. Belmont, W. Benbow, D. Berge, E. Bernardini, M.I. Bernardos, K. Bernlöhr, A. Berti, M. Berton, B. Bertucci, V. Beshley, N. Bhatt, S. Bhattacharyya, W. Bhattacharyya, B. Y. Bi, G. Bicknell, N. Biederbeck, C. Bigongiari, A. Biland, R. Bird, E. Bissaldi, J. Biteau, M. Bitossi, O. Blanch, M. Blank, J. Blazek, J. Bobin, C. Boccato, F. Bocchino, C. Boehm, M. Bohacova, C. Boisson, J. Boix, J.P. Bolle, J. Bolmont, G. Bonanno, C. Bonavolontà, L. Bonneau Arbeletche, G. Bonnoli, P. Bordas, J. Borkowski, R. Bose, D. Bose, Z. Bosnjak, E. Bottacini, Markus Böttcher, M.T. Botticella, C. Boutonnet, F. Bouyjou, V. Bozhilov, E. Bozzo, L. Brahimi, C. Braiding, S. Brau Nogue, S. Breen, J. Bregeon, M. Breuhaus, A. Brill, W. Brisken, E. Brocato, A.M. Brown, K. Brügge, P. Brun, F. Brun, L. Brunetti, G. Brunetti, P. Bruno, A. Bruno, A. Bruzzese, N. Bucciantini, J. H. Buckley, R. Bühler, A. Bulgarelli, T. Bulik, M. Bünning, M. Bunse, M. Burton, A. Burtovoi, M. Buscemi, S. Buschjager, G. Busetto, J. Buss, K. Byrum, A. Caccianiga, F. Cadoux, A. Calanducci, C. Calderon, J. Calvo Tovar, R. A. Cameron, P. Campana, R. Canestrari, F. Cangemi, B. Cantlay, M. Capalbi, M. Capasso, M. Cappi, A. Caproni, R. Capuzzo Dolcetta, P. Caraveo, V. Cárdenas, L. Cardiel, M. Cardillo, C. Carlile, S. Caroff, R. Carosi, A. Carosi, E. Carquin, M. Carrere, J.M. Casandjian, S. Casanova, F. Cassol, F. Catalani, O. Catalano, D. Cauz, A. Ceccanti, C. Celestino Silva, K. Cerny, M. Cerruti, E. Chabanne, P. Chadwick, Y. Chai, P. Chambery, C. Champion, S. Chaty, A. Chen, K. Cheng, M. Chernyakova, G. Chiaro, A. Chiavassa, M. Chikawa, V.R. Chitnis, J. Chudoba, L. Chytka, S. Cikota, A. Circiello, P. Clark, M. Colak, E. Colombo, S. Colonges, A. Comastri, A. Compagnino, V. Conforti, E. Congiu, R. Coniglione, J. Conrad, F. Conte, J.L. Contreras, P. Coppi, R. Cornat, J. Coronado Blazquez, J. Cortina, A. Costa, H. Costantini, G. Cotter, B. Courty, S. Covino, S. Crestan, P. Cristofari, R. Crocker, J. Croston, K. Cubuk, O. Cuevas, X. Cui, G. Cusumano, S. Cutini, G. D'Amico, F. D'Ammando, P. D'Avanzo, P. Da Vela, M. Dadina, S. Dai, M. Dalchenko, M. Dall'Ora, M.K. Daniel, J. Dauguet, I. Davids, J. Davies, B. Dawson, A. De Angelis, A.E. de Araujo Carvalho, M. de Bony de Lavergne, G. De Cesare, F. de Frondat, I. de la Calle, E. de Gouveia Dal Pino, B. De Lotto, A. De Luca, D. De Martino, M. de Naurois, E. de Ona Wilhelmi, F. De Palma Persio, N. De Simone, V. de Souza Valle, E. Delagnes, G. Deleglise Reznicek, C. Delgado, A.G. Delgado Giler, J. Delgado Mengual Valle, Domenico Della Volpe, D. Depaoli, J. Devin, T. Di Girolamo, C. Di Giulio Pierro, L. Di Venere, C. Díaz, C. Dib, S. Diebold, S. Digel, A. Djannati Atai, J. Djuvsland, A. Dmytriiev, K. Docher, A. Domínguez, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, Rita Cassia dos Anjos, J.L. Dournaux, T. Downes, G. Drake, H. Drass, D. Dravins, C. Duangchan, A. Duara, G. Dubus, L. Ducci, C. Duffy, D. Dumora, K. Dundas Mora, A. Durkalec, V.V. Dwarkadas, J. Ebr, C. Eckner, J. Eder, E. Edy, K. Egberts, S. Einecke, C. Eleftheriadis, D. Elsässer, G. Emery, D. Emmanoulopoulos, J.P. Ernenwein, M. Errando, P. Escarate, J. Escudero, C. Espinoza, S. Ettori, A. Eungwanichayapant, P. Evans, C. Evoli, M. Fairbairn, D. Falceta Goncalves, A. Falcone, V. Fallah Ramazanı, R. Falomo, K. Farakos, G. Fasola, A. Fattorini, Y. Favre, R. Fedora, E. Fedorova, K. Feijen, Q. Feng, G. Ferrand, G. Ferrara, O. Ferreira, M. Fesquet, E. Fiandrini, A. Fiasson, M. Filipovic, D. Fink, J.P. Finley, V. Fioretti, D.F.G. Fiorillo, M. Fiorini, S. Flis, H. Flores, L. Foffano, C. Fohr, M.V. Fonseca, L. Font, G. Fontaine, O. Fornieri, P. Fortin, L. Fortson, N. Fouque, B. Fraga, A. Franceschini, F.J. Franco, L. Freixas Coromina, L. Fresnillo, D. Fugazza, Y. Fujita, S. Fukami, Y. Fukazawa, D. Fulla, S. Funk, A. Furniss, S. Gabici, D. Gaggero, G. Galanti, P. Galdemard, Y. A. Gallant, D. Galloway, S. Gallozzi, V. Gammaldi, R. Garcia, L. E. García-Muñoz, E. Garcia Lopez, F. Gargano, C. Gargano, S. Garozzo, D. Gascon, T. Gasparetto, D. Gasparrini, H. Gasparyan, M. Gaug, N. Geffroy, A. Gent, S. Germani, A. Ghalumyan, A. Ghedina, G. Ghirlanda, F. Gianotti, S. Giarrusso, M. Giarrusso, G. Giavitto, B. Giebels, N. Giglietto, V. Gika, F. Gillardo, R. Gimenes, F. Giordano, E. Giro, M. Giroletti, Andrea Giuliani, M. Gjaja, J.F. Glicenstein, P. Gliwny, H. Goksu, P. Goldoni, J.L. Gomez, M.M. Gonzalez, Juan Manuel Gonzalez, K.S. Gothe, D. Gotz Coelho, T. Grabarczyk, R. Graciani, P. Grandi, G. Grasseau, D. Grasso, D. Green, J. Green, T. Greenshaw, P. Grespan, A. Grillo, M.H. Grondin, J. Grube, V. Guarino, B. Guest, O. Gueta, M. Günduz, S. Gunji, G. Gyuk, J. Hackfeld, D. Hadasch, L. Hagge, A. Hahn, J.E. Hajlaoui, A. Halim, P. Hamal, W. Hanlon, Y. Harada, M.J. Hardcastle, M. Harvey Collado, T. Haubold, A. Haupt, M. Havelka, K. Hayashi, M. Hayashida, H. He, L. Heckmann, M. Heller, F. Henault, Gilles Henri, G. Hermann, S. Hernández Cadena, J. Herrera Llorente, O. Hervet, J. Hinton, A. Hiramatsu, K. Hirotani, B. Hnatyk, R. Hnatyk, J.K. Hoang, D. H.H. Hoffmann, C. Hoischen, J. Holder, M. Holler, B. Hona, D. Horan, Dieter Horns, P. Horvath, J. Houles, M. Hrabovsky, D. Hrupec, Y. Huang, J.‑M. Huet, G. Hughes, G. Hull, T.B. Humensky, M. Hütten, M. Iarlori, J.M. Illa, R. Imazawa, T. Inada, F. Incardona, A. Ingallinera, S. Inoue, T. Inoue, Y. Inoue, F. Iocco, K. Ioka, M. Ionica, S. Iovenitti, A. Iriarte, K. Ishio, W. Ishizaki, Y. Iwamura, J. Jacquemier, M. Jacquemont, M. Jamrozy, P. Janecek, F. Jankowsky, A. JardinBlicq, C. Jarnot, P. Jean Martínez, L. Jocou, N. Jordana, M. Josselin, I. JungRichardt, F.J.P.A. Junqueira, C. Juramy Gilles, P. Kaaret, L.H.S. Kadowaki, M. Kagaya, R. Kankanyan, D. Kantzas, V. Karas, A. Karastergiou, S. Karkar, J. Kasperek, H. Katagiri, J. Kataoka, K. Katarzynski, S. Katsuda, N. Kawanaka, D. Kazanas, D. Kerszberg, B. Khélifi, M.C. Kherlakian, T.P. Kian, D.B. Kieda, T. Kihm, S. Kim, S. Kisaka, R. Kissmann, R. Kleijwegt, G. Kluge, W. Kluźniak, J. Knapp, A. Kobakhidze, Y. Kobayashi, B. Koch, J. Kocot, K. Kohri, N. Komin, A. Kong, K. Kosack, F. Krack, M. Krause, F. Krennrich, H. Kubo, V. N. Kudryavtsev, S. Kunwar, J. Kushida, P. Kushwaha, Barbera Parola, G. La Rosa, R. Lahmann, A. Lamastra, M. Landoni, D. Landriu, R.G. Lang, J. Lapington, P. Laporte, P. Lason, J. Lasuik, J. Lazendic Galloway, T. Le Flour, P. Le Sidaner, S. Leach, S.H. Lee, W.H. Lee, S. Lee Oliveira, A. Lemiere, M. Lemoine Goumard, J.P. Lenain, F. Leone, V. Leray, G. Leto, F. Leuschner, R. Lindemann, E. Lindfors, L. Linhoff, I. Liodakis, A. Lipniacka, M. Lobo, Thomas Lohse, S. Lombardi, A. Lopez, M. Lopez, R. Lopez Coto, F. Louis, M. Louys, F. Lucarelli, H. Ludwig Boudi, P.L. Luque Escamilla, M.C. Maccarone, E. Mach, A.J. Maciejewski, J. Mackey, P. Maeght, C. Maggio, G. Maier, P. Majumdar, M. Makariev, M. Mallamaci, R. Malta Nunes de Almeida, D. Malyshev, D. Mandat, G. Maneva, M. Manganaro, P. Manigot, K. Mannheim, N. Maragos, D. Marano, M. Marconi, A. Marcowith, M. Marculewicz, B. Marcun, J. Marin, N. Marinello, P. Marinos, S. Markoff, P. Marquez, G. Marsella, J. M. Martin, P. G. Martin, M. Martinez, G. Martinez, O. Martinez, H. Martinez Huerta, C. Marty, R. Marx, N. Masetti, P. Massimino, H. Matsumoto, N. Matthews, G. Maurin, W. Max Moerbeck, N. Maxted, M.N. Mazziotta, S.M. Mazzola, J.D. Mbarubucyeye, L. Mc Comb, I. McHardy, S. McKeague, S. McMuldroch, E. Medina, D. Medina Miranda, A. Melandri, C. Melioli, D. Melkumyan, S. Menchiari, S. Mereghetti, G. Merino Arevalo, E. Mestre, J.L. Meunier, T. Meures, S. Micanovic, M. Miceli, M. Michailidis, J. Michalowski, T. Miener, I. Mievre, J. D. Miller, T. Mineo, M. Minev, J.M. Miranda, A. Mitchell, T. Mizuno, B. A. Mode, R. Moderski, L. Mohrmann, E. Molinari, T. Montaruli, I. Monteiro, C. Moore, A. Moralejo, D. Morcuende Parrilla, E. Moretti, K. Mori, P. Moriarty, K. Morik, P. Morris, A. Morselli, K. Mosshammer, R. Mukherjee, J. Muller, C. Mundell, J. Mundet, T. Murach, A. Muraczewski, H. Muraishi, I. Musella, A. Musumarra, A. Nagai, S. Nagataki, T. Naito, T. Nakamori, K. Nakashima, K. Nakayama, N. Nakhjiri, G. Naletto, D. Naumann, L. Nava, M.A. Nawaz, H. Ndiyavala, D. Neise, L. Nellen, R. Nemmen, N. Neyroud, K. Ngernphat, T. Nguyen Trung, L. Nicastro, L. Nickel, J. Niemiec, D. Nieto, C. Nigro, M. Nikołajuk, D. Ninci, K. Noda, Y. Nogami, S. Nolan, R. P. Norris, D. Nosek, M. Nöthe, V. Novotny, S. Nozaki, F. Nunio, P. O'Brien, K. Obara, Y. Ohira, M. Ohishi, S. Ohm, T. Oka, N. Okazaki, A. Okumura, C. Oliver, G. Olivera, B. Olmi, M. Orienti, R. Orito, M. Orlandini, E. Orlando, J.P. Osborne, M. Ostrowski, N. Otte, E. Ovcharov, E. Owen, I. Oya, A. Ozieblo, M. Padovani, A. Pagliaro, A. Paizis, M. Palatiello, M. Palatka, E. Palazzi, J.‑L. Panazol, D. Paneque, S. Panny, Francesca Romana Pantaleo, M. Panter, M. Paolillo, A. Papitto, A. Paravac, J.M. Paredes, G. Pareschi, N. Parmiggiani, R.D. Parsons, P. Paśko, S. R. Patel, B. Patricelli, L. Pavletic, S. Pavy, A. Peer, M. Pecimotika, M.G. Pellegriti, P. Peñil Del Campo, A. Pepato, S. Perard, C. Perennes, M. Peresano, A. Perez Aguilera, J. Perez Romero, M.A. Perez Torres, M. Persic, P. O. Petrucci, O. Petruk, B. Peyaud, K. Pfrang, E. Pian, P. Piatteli, E. Pietropaolo, R. Pillera, D. Pimentel, F. Pintore, C. Pio Garcia, G. Pirola, F. Piron, S. Pita, M. Pohl, V. Poireau, A. Pollo, M. Polo, C. Pongkitivanichkul, J. Porthault, J. Powell, D. Pozo, R.R. Prado, E. Prandini, J. Prast, K. Pressard, G. Principe, N. Produit, D. Prokhorov, H. Prokoph, H. Przybilski, E. Pueschel, G. Pühlhofer, I. Puljak, M.L. Pumo, M. Punch, F. Queiroz, J. Quinn, A. Quirrenbach, P.J. Rajda, R. Rando, S. Razzaque, S. Recchia, P. Reichherzer, O. Reimer, A. Reisenegger, Q. Remy, M. Renaud, T. Reposeur, B. Reville, J.M. Reymond, J. Reynolds, D. Ribeiro, M. Ribo, G. Richards, J. Rico, F. Rieger, L. Riitano, M. Riquelme, D. Riquelme, S. Rivoire, V. Rizi, E. Roache, M. Roche, J. Rodriguez, G. Rodriguez Fernandez, J.C. Rodriguez Ramirez, J.J. Rodriguez Vazquez, G. Rojas, P. Romano, G. Romeo Lobato, C. Romoli, M. Roncadelli, J. Rosado, A. Rosales de Leon, G. Rowell, A. Rugliancich, J.E. Ruiz del Mazo, C. Rulten, C. Russell, F. Russo Hatlen, S. Safi Harb, L. Saha, V. Sahakian, S. Sailer, T. Saito, N. Sakaki, S. Sakurai, G. Salina, H. Salzmann, D. Sanchez, H. Sandaker, A. Sandoval, P. Sangiorgi, M. Sanguillon, H. Sano, M. Santander, A. Santangelo, R. Santos Lima, A. Sanuy, L. Sapozhnikov, T. Saric, S. Sarkar, H. Sasaki, N. Sasaki, Y. Sato, F.G. Saturni, M. Sawada, J. Schaefer, A. Scherer, J. Scherpenberg, P. Schipani, B. Schleicher, J. Schmoll, M. Schneider, H. Schoorlemmer, P. Schovanek, F. Schussler, B. Schwab, U. Schwanke, J. Schwarz, E. Sciacca, S. Scuderi, M. Seglar Arroyo, I. Seitenzahl, D. Semikoz, O. Sergijenko, J.E. Serna Franco, Karol Seweryn, V. Sguera, A. Shalchi, R.Y. Shang, P. Sharma, L. Sidoli, J. Sieiro, H. Siejkowski, A. Sillanpaa, B.B. Singh, K.K. Singh, A. Sinha, C. Siqueira, J. Sitarek, P. Sizun, V. Sliusar, D. Sobczynska, R.W. Sobrinho, H. Sol, G. Sottile, H. Spackman, S. Spencer, G. Spengler, D. Spiga, W. Springer, A. Stamerra, S. Stanic, R. Starling, Ł. Stawarz, Stanislav Stefanik, C. Stegmann, A. Steiner, S. Steinmassl, C. Stella, R. Sternberger, M. Sterzel, C. Stevens, B. Stevenson, T. Stolarczyk, G. Stratta, U. Straumann, J. Striskovic, M. Strzys, R. Stuik, M. Suchenek, Y. Sunada, Tiina Suomijarvi, T. Suric, H. Suzuki, P. Swierk, T. Szepieniec, K. Tachihara, G. Tagliaferri, H. Tajima, N. Tajima, D. Tak, H. Takahashi, M. Takahashi, J. Takata, R. Takeishi, T. Tam, M. Tanaka, T. Tanaka, S. Tanaka, M. Tavani, F. Tavecchio, T. Tavernier, A. Russ Taylor, L.A. Tejedor, P. Temnikov, K. Terauchi, J.C. Terrazas, R. Terrier, T. Terzic, M. Teshima, D. Thibaut, F. Thocquenne, W. Tian, L. Tibaldo, A. Tiengo, M. Tluczykont, C.J. Todero Peixoto, K. Toma, L. Tomankova, J. Tomastik, M. Tornikoski, D.F. Torres, E. Torresi, G. Tosti, L. Tosti, N. Tothill, F. Toussenel, G. Tovmassian, C. Trichard, M. Trifoglio, A. Trois, S. Truzzi, A. Tsiahina, B. Turk, A. Tutone, Y. Uchiyama, P. Utayarat, L. Vaclavek, M. Vacula, V. Vagelli, F. Vagnetti, J.A. Valdivia, M. Valentino, A. Valio, B. Vallage, P. Vallania Quispe, A.M. van den Berg, W. van Driel, C. van Eldik, C. van Rensburg, Brian van Soelen, J. Vandenbroucke, G. Vasileiadis, V. Vassiliev, M. Vazquez Acosta, M. Vecchi, A. Vega, J. Veh, P. Veitch, C. Venter, S. Ventura, S. Vercellone, V. Verguilov, G. Verna, S. Vernetto, V. Verzi, G.P. Vettolani, C. Veyssiere, I. Viale, A. Viana, N. Viaux, J. Vignatti, C.F. Vigorito, J. Villanueva, V. Vitale, V. Vittorini, V. Vodeb, N. Vogel, V. Voisin, S. Vorobiov, M. Vrastil, T. Vuillaume, S.J. Wagner, P. Wagner, K. Wakazono, S.P. Wakely, M. Ward, D. Warren, J. Watson, M. Wechakama, P. Wegner, A. Weinstein, C. Weniger, F. Werner, H. Wetteskind, M. L. White, A. Wierzcholska, S. Wiesand, R. Wijers, M. Wilkinson, M. Will, J. Williams, T. J. Williamson, A. Wolter, Y.W. Wong, M. Wood, T. Yamamoto, H. Yamamoto, Y. Yamane, R. Yamazaki, S. Yanagita, L. Yang, S. Yoo, T. Yoshida, T. Yoshikoshi, P. Yu, A. Yusafzai, Michael Zacharias, B. Zaldivar, L. Zampieri, R. Zanin, R. Zanmar Sanchez, D. Zaric, M. Zavrtanik, D. Zavrtanik, Andrzej Zdziarski, A. Zech, H. Zechlin, A. Zenin, A. Zerwekh, K. Ziętara, A. Zink, J. Ziolkowski, M. Zivec, A. Zmija, Współautorami artykułu są członkowie CTA Observatory, CTA Consortium i LST Collaboration w liczbie 1139, Astronomy, Research unit Nuclear & Hadron Physics, and Research unit Astroparticle Physics
Subjects: Physics, Observatory, Gamma ray, Astronomy
Abstract: Very-high Energy (VHE) gamma-ray astroparticle physics is a relatively young field, and observations over the past decade have surprisingly revealed almost two hundred VHE emitters which appear to act as cosmic particle accelerators. These sources are an important component of the Universe, influencing the evolution of stars and galaxies. At the same time, they also act as a probe of physics in the most extreme environments known - such as in supernova explosions, and around or after the merging of black holes and neutron stars. However, the existing experiments have provided exciting glimpses, but often falling short of supplying the full answer. A deeper understanding of the TeV sky requires a significant improvement in sensitivity at TeV energies, a wider energy coverage from tens of GeV to hundreds of TeV and a much better angular and energy resolution with respect to the currently running facilities. The next generation gamma-ray observatory, the Cherenkov Telescope Array Observatory (CTAO), is the answer to this need. In this talk I will present this upcoming observatory from its design to the construction, and its potential science exploitation. CTAO will allow the entire astronomical community to explore a new discovery space that will likely lead to paradigm-changing breakthroughs. In particular, CTA has an unprecedented sensitivity to short (sub-minute) timescale phenomena, placing it as a key instrument in the future of multi-messenger and multi-wavelength time domain astronomy. I will conclude the talk presenting the first scientific results obtained by the LST-1, the prototype of one CTAO telescope type - the Large-Sized Telescope, that is currently under commission., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference (ICRC2021)
Published: 2022

6. Galactic Observatory Science with the ASTRI Mini-Array at the Observatorio del Teide

Author: A. D'Aì, E. Amato, A. Burtovoi, A.A. Compagnino, M. Fiori, A. Giuliani, N. La Palombara, A. Paizis, G. Piano, F.G. Saturni, A. Tutone, A. Belfiore, M. Cardillo, S. Crestan, G. Cusumano, M. Della Valle, M. Del Santo, A. La Barbera, V. La Parola, S. Lombardi, S. Mereghetti, G. Morlino, F. Pintore, P. Romano, S. Vercellone, A. Antonelli, C. Arcaro, C. Bigongiari, M. Böettcher, P. Bruno, A. Bulgarelli, V. Conforti, A. Costa, E. de Gouveia Dal Pino, V. Fioretti, S. Germani, A. Ghedina, F. Gianotti, V. Giordano, F. Incardona, G. Leto, F. Longo, A. López Oramas, F. Lucarelli, B. Olmi, A. Pagliaro, N. Parmiggiani, G. Romeo, A. Stamerra, V. Testa, G. Tosti, G. Umana, L. Zampieri, P. Caraveo, and G. Pareschi
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: The ASTRI (Astrofisica con Specchi a Tecnologia Replicante Italiana) Mini-Array will be composed of nine imaging atmospheric Cherenkov telescopes at the Observatorio del Teide site. The array will be best suited for astrophysical observations in the 0.3-200 TeV range with an angular resolution of few arc-minutes and an energy resolution of 10-15\%. A core-science programme in the first four years will be devoted to a limited number of key targets, addressing the most important open scientific questions in the very-high energy domain. At the same time, thanks to a wide field of view of about 10 degrees, ASTRI Mini-Array will observe many additional field sources, which will constitute the basis for the long-term observatory programme that will eventually cover all the accessible sky. In this paper, we review different astrophysical Galactic environments, e.g. pulsar wind nebulae, supernova remnants, and gamma-ray binaries, and show the results from a set of ASTRI Mini-Array simulations of some of these field sources made to highlight the expected performance of the array (even at large offset angles) and the important additional observatory science that will complement the core-science program., Comment: Accepted for publication in Journal of High-Energy Astrophysics
Published: 2022
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7. ASTRI Mini-Array Core Science at the Observatorio del Teide

Author: S. Vercellone, C. Bigongiari, A. Burtovoi, M. Cardillo, O. Catalano, A. Franceschini, S. Lombardi, L. Nava, F. Pintore, A. Stamerra, F. Tavecchio, L. Zampieri, R. Alves Batista, E. Amato, L.A. Antonelli, C. Arcaro, J. Becerra González, G. Bonnoli, M. Böttcher, G. Brunetti, A.A. Compagnino, S. Crestan, A. D'Aì, M. Fiori, G. Galanti, A. Giuliani, E.M. de Gouveia Dal Pino, J.G. Green, A. Lamastra, M. Landoni, F. Lucarelli, G. Morlino, B. Olmi, E. Peretti, G. Piano, G. Ponti, E. Poretti, P. Romano, F.G. Saturni, S. Scuderi, A. Tutone, G. Umana, J.A. Acosta-Pulido, P. Barai, A. Bonanno, G. Bonanno, P. Bruno, A. Bulgarelli, V. Conforti, A. Costa, G. Cusumano, M. Del Santo, M.V. del Valle, R. Della Ceca, D.A. Falceta-Gonçalves, V. Fioretti, S. Germani, R.J. García-López, A. Ghedina, F. Gianotti, V. Giordano, M. Kreter, F. Incardona, S. Iovenitti, A. La Barbera, N. La Palombara, V. La Parola, G. Leto, F. Longo, A. López-Oramas, M.C. Maccarone, S. Mereghetti, R. Millul, G. Naletto, A. Pagliaro, N. Parmiggiani, C. Righi, J.C. Rodríguez-Ramírez, G. Romeo, P. Sangiorgi, R. Santos de Lima, G. Tagliaferri, V. Testa, G. Tosti, M. Vázquez Acosta, N. Żywucka, P.A. Caraveo, and G. Pareschi
Subjects: ASTRI, Imaging atmospheric Cherenkov arrays, Very high-energy gamma ray astrophysics, Astroparticle, High Energy Astrophysical Phenomena (astro-ph.HE), Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: The ASTRI (Astrofisica con Specchi a Tecnologia Replicante Italiana) Project led by the Italian National Institute for Astrophysics (INAF) is developing and will deploy at the Observatorio del Teide a mini-array (ASTRI Mini-Array) composed of nine telescopes similar to the small-size dual-mirror Schwarzschild-Couder telescope (ASTRI-Horn) currently operating on the slopes of Mt. Etna in Sicily. The ASTRI Mini-Array will surpass the current Cherenkov telescope array differential sensitivity above a few tera-electronvolt (TeV), extending the energy band well above hundreds of TeV. This will allow us to explore a new window of the electromagnetic spectrum, by convolving the sensitivity performance with excellent angular and energy resolution figures. In this paper we describe the Core Science that we will address during the first four years of operation, providing examples of the breakthrough results that we will obtain when dealing with current open questions, such as the acceleration of cosmic rays, cosmology and fundamental physics and the new window, for the TeV energy band, of the time-domain astrophysics., Comment: Published in Journal of High Energy Astrophysics. 46 Figures, 7 Tables
Published: 2022
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8. QUBIC Experiment Toward the First Light

Author: G. D’Alessandro, E. S. Battistelli, P. de Bernardis, M. De Petris, M. M. Gamboa Lerena, L. Grandsire, J.-Ch. Hamilton, S. Marnieros, S. Masi, A. Mennella, L. Mousset, C. O’Sullivan, M. Piat, A. Tartari, S. A. Torchinsky, F. Voisin, M. Zannoni, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, S. Banfi, A. Baù, B. Bélier, D. Bennett, L. Bergé, J.-Ph. Bernard, M. Bersanelli, M.-A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Burke, D. Buzi, F. Cavaliere, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, C. Franceschet, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. Gómez Berisso, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, B. Maffei, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, A. Paiella, F. Pajot, A. Passerini, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Pezzotta, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, G. Presta, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, A. Schillaci, C. G. Scóccola, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J.-P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, D. Viganò, N. Vittorio, F. Wicek, M. Wright, A. Zullo, D’Alessandro, G, Battistelli, E, de Bernardis, P, De Petris, M, Gamboa Lerena, M, Grandsire, L, Hamilton, J, Marnieros, S, Masi, S, Mennella, A, Mousset, L, O’Sullivan, C, Piat, M, Tartari, A, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Presta, G, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Wicek, F, Wright, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), and QUBIC
Subjects: Instruments, mm-wave, Applications, astrophysics and cosmology, Settore FIS/05, Applications: astrophysics and cosmology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, FIS/05 - ASTRONOMIA E ASTROFISICA, FIS/01 - FISICA SPERIMENTALE, Settore FIS/05 - Astronomia e Astrofisica, Instruments: mm-wave, Instruments: mm-wave · Applications: astrophysics and cosmology, General Materials Science, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: International audience; The Q & U Bolometric Interferometer for Cosmology (QUBIC) is a cosmology experiment that aims to measure the B-mode polarization of the cosmic microwave background (CMB). Measurements of the primordial B-mode pattern of the CMB polarization are in fact among the most exciting goals in cosmology as it would allow testing of the inflationary paradigm. Many experiments are attempting to measure the B-modes, from the ground and the stratosphere, using imaging Stokes polarimeters. The QUBIC collaboration developed an innovative concept to measure CMB polarization using bolometric interferometry. This approach mixes the high sensitivity of bolometric detectors with the accurate control of systematics due to the interferometric layout of the instrument. We present the calibration results for the Technological Demonstrator, before its commissioning in the Argentinian observing site and preparation for first light.
Published: 2022

9. The QUBIC instrument for CMB polarization measurements

Author: A. Bottani, E. Jules, A. Zullo, Federico Nati, V. Gilles, A. Baù, L. Mousset, Giampaolo Pisano, C. Perbost, C. Oriol, Damien Rambaud, G. Amico, D. Buzi, Emory F. Bunn, M. Tomasi, L. H. Arnaldi, A. Etchegoyen, S. Azzoni, F. Wicek, Marco Bersanelli, Mark McCulloch, Alejandro Almela, Mario Zannoni, M. Perciballi, Peter A. R. Ade, A. Pelosi, Maria Salatino, D. Auguste, S. Scully, M. Gómez Berisso, F. Piacentini, Andrea Tartari, M. Platino, Martin Giard, P. Chanial, Jonathan Aumont, C. Scóccola, M.-A. Bigot-Sazy, Alessandro Paiella, Lucio Piccirillo, C. Kristukat, Federico Pezzotta, Carole Tucker, A. Passerini, Sophie Henrot-Versille, J.-Ch. Hamilton, Nicola Vittorio, M. De Leo, M. Tristram, J. G. Alberro, G. D' Alessandro, L. M. Mundo, Cristian Franceschet, Massimo Gervasi, B. Maffei, L. Grandsire, M. De Petris, K. Ganga, Francesco Cavaliere, S. Marnieros, S. Loucatos, Michel Piat, D. Fracchia, J. Bonaparte, Créidhe O'Sullivan, Laurent Bergé, N. Bleurvacq, A. Mattei, J. Bonis, Gianluca Polenta, L. Mele, J.-P. Bernard, W. Marty, E. Olivieri, H. Pastoriza, Peter Timbie, D. Harari, A. Mennella, D. L. Burke, F. Columbro, Steve Torchinsky, S. Melhuish, Bruce Rafael Mellado Garcia, L.P. Ferreyro, M. Stolpovskiy, Gustavo E. Romero, M. M. Gamboa Lerena, D. T. Hoang, R. Puddu, F. Incardona, D. Bennett, Alessandro Coppolecchia, M. González, S. Spinelli, T. Louis, C. Chapron, P. de Bernardis, P. Ringegni, Marcin Gradziel, François Pajot, A. Fasciszewski, G. Stankowiak, D. Viganò, Luca Lamagna, Alessandro Schillaci, R. Charlassier, L. Dumoulin, J.-P. Thermeau, Andrew May, G. de Gasperis, S. Banfi, Y. Giraud-Heraud, Silvia Masi, J. Kaplan, M. E. García Redondo, J.D. Murphy, B. Bélier, J.M. Salum, S. Dheilly, J. A. Murphy, M. Gaspard, L. A. Montier, Elia S. Battistelli, D. Gayer, F. Voisin, D. Prêle, Gregory S. Tucker, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Mele, L, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Battistelli, E, Ba, A, B lier, B, Bennett, D, Berge, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bleurvacq, N, Bonaparte, J, Bonis, J, Bottani, A, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Columbro, F, Coppolecchia, A, D'Alessandro, G, Bernardis, P, Gasperis, G, Leo, M, Petris, M, Dheilly, S, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Lerena, M, Ganga, K, Garcia, B, Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gomez Berisso, M, Gonzalez, M, Gradziel, M, Grandsire, L, Hamilton, J, Harari, D, Henrot-Versille, S, Hoang, D, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marnieros, S, Marty, W, Masi, S, Mattei, A, May, A, Mcculloch, M, Melhuish, S, Mennella, A, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, O'Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piat, M, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Pr le, D, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Salatino, M, Salum, J, Schillaci, A, Scoccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Torchinsky, S, Tristram, M, Tucker, G, Tucker, C, Vigan, D, Vittorio, N, Voisin, F, Wicek, F, Zannoni, M, and Zullo, A
Subjects: History, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], interferometer, Cosmic microwave background, Polarimetry, cosmic background radiation: polarization, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Cosmology, Education, law.invention, qubic, polarimetry, bolometric interferometry, cmb, b modes, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, bolometer, law, 0103 physical sciences, Astronomical interferometer, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, 010303 astronomy & astrophysics, detector: design, ComputingMilieux_MISCELLANEOUS, Physics, polarization, business.industry, Gravitational wave, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Polarization (waves), calibration, polarization: monitoring, Computer Science Applications, Bolometers, Cosmology, Interferometers, Inflation, Cosmic microwave background, Polarization, Interferometry, modulation, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], performance
Abstract: Measurements of cosmic microwave background (CMB) polarization may reveal the presence of a background of gravitational waves produced during cosmic inflation, providing thus a test of inflationary models. The Q&U Bolometric Interferometer for Cosmology (QUBIC) is an experiment designed to measure the CMB polarization. It is based on the novel concept of bolometric interferometry, which combines the sensitivity of bolometric detectors with the properties of beam synthesis and control of calibration offered by interferometers. To modulate and extract the input polarized signal of the CMB, QUBIC exploits Stokes polarimetry based on a rotating half-wave plate (HWP). In this work, we illustrate the design of the QUBIC instrument, focusing on the polarization modulation system, and we present preliminary results of beam calibrations and the performance of the HWP rotator at 300 K.
Published: 2021

10. The Monitoring, Logging, and Alarm system for the Cherenkov Telescope Array

Author: Stefano Germani, Pietro Bruno, Eva Sciacca, Alessandro Grillo, Kevin Munari, Igor Oya, Ugo Becciani, Mario Raciti, Alessandro Costa, and F. Incardona
Subjects: Downtime, ALARM, Data acquisition, Computer science, Interface (computing), Real-time computing, FOS: Physical sciences, Astrophysics - Instrumentation and Methods for Astrophysics, Cherenkov Telescope Array, Instrumentation and Methods for Astrophysics (astro-ph.IM), Predictive maintenance, Fault detection and isolation, System software
Abstract: We present the current development of the Monitoring, Logging and Alarm subsystems in the framework of the Array Control and Data Acquisition System (ACADA) for the Cherenkov Telescope Array (CTA). The Monitoring System (MON) is the subsystem responsible for monitoring and logging the overall array (at each of the CTA sites) through the acquisition of monitoring and logging information from the array elements. The MON allows us to perform a systematic approach to fault detection and diagnosis supporting corrective and predictive maintenance to minimize the downtime of the system. We present a unified tool for monitoring data items from the telescopes and other devices deployed at the CTA array sites. Data are immediately available for the operator interface and quick-look quality checks and stored for later detailed inspection. The Array Alarm System (AAS) is the subsystem that provides the service that gathers, filters, exposes, and persists alarms raised by both the ACADA processes and the array elements supervised by the ACADA system. It collects alarms from the telescopes, the array calibration, the environmental monitoring instruments and the ACADA systems. The AAS sub-system also creates new alarms based on the analysis and correlation of the system software logs and the status of the system hardware providing the filter mechanisms for all the alarms. Data from the alarm system are then sent to the operator via the human-machine interface.
Published: 2021

11. LOgging UnifieD for ASTRI Mini Array

Author: Giuseppe Tudisco, Stefano Germani, Joseph Schwarz, Pietro Bruno, Kevin Munari, F. Incardona, Fabio Vitello, Alessandro Grillo, Andrea Bulgarelli, Alessandro Costa, Eva Sciacca, and Gino Tosti
Subjects: Service (systems architecture), business.industry, Computer science, FOS: Physical sciences, computer.software_genre, Lidar, Software, Data acquisition, SCADA, Observatory, Gamma ray astrophysics, Operating system, Software system, Astrophysics - Instrumentation and Methods for Astrophysics, business, Instrumentation and Methods for Astrophysics (astro-ph.IM), computer
Abstract: The ASTRI (Astrofisica con Specchi a Tecnologia Replicante Italiana) Mini-Array (MA) project is an international collaboration led by the Italian National Institute for Astrophysics (INAF). ASTRI MA is composed of nine Cherenkov telescopes operating in the energy range 1-100 TeV, and it aims to study very high-energy gamma ray astrophysics and optical intensity interferometry of bright stars. ASTRI MA is currently under construction, and will be installed at the site of the Teide Observatory in Tenerife (Spain). The hardware and software system that is responsible of monitoring and controlling all the operations carried out at the ASTRI MA site is the Supervision Control and Data Acquisition (SCADA). The LOgging UnifieD (LOUD) subsystem is one of the main components of SCADA. It provides the service responsible for collecting, filtering, exposing and storing log events collected by all the array elements (telescopes, LIDAR, devices, etc.). In this paper, we present the LOUD architecture and the software stack explicitly designed for distributed computing environments exploiting Internet of Things technologies (IoT).
Published: 2021

12. Detection chain and electronic readout of the QUBIC instrument

Author: L. M. Mundo, S. Marnieros, D. Fracchia, A. Mattei, R. Puddu, S. Spinelli, A. Passerini, Federico Nati, V. Gilles, K. Ganga, B. García, Giuseppe D'Alessandro, F. Wicek, P. A. R. Ade, Diego Harari, J. Bonaparte, F. Pezzotta, Massimo Gervasi, F. Incardona, M. E. García Redondo, M. Platino, L. Grandsire, J. D. Murphy, Damien Rambaud, E. Jules, M. Wright, C. Kristukat, L. Dumoulin, E. Olivieri, B. Maffei, Alessandro Paiella, J. Bonis, J.-P. Thermeau, D. Prêle, H. Pastoriza, Michel Piat, M. Gómez Berisso, M. Perciballi, F. Piacentini, D. Burke, Mark McCulloch, A. Zullo, L. H. Arnaldi, Giampaolo Pisano, A. Baù, L.P. Ferreyro, C. Perbost, C. Duca, C. Franceschet, L. Mousset, J. A. Murphy, D. Viganò, Gustavo E. Romero, Martin Giard, Emory F. Bunn, Alessandro Schillaci, Gregory S. Tucker, P. Chanial, L. A. Montier, M.-A. Bigot-Sazy, Alejandro Almela, A. Etchegoyen, Marco Bersanelli, E. Rasztocky, M. Gaspard, Nicola Vittorio, Mario Zannoni, A. Pelosi, S. Azzoni, P. de Bernardis, T. D. Hoang, S. Banfi, W. Marty, A. Mennella, S. Scully, M. M. Gamboa Lerena, Elia S. Battistelli, Andrea Tartari, J.G. Alberro, D. Gayer, Alessandro Coppolecchia, C. Oriol, J.M. Salum, J. Aumont, D. Bennett, S. Loucatos, Silvia Masi, Marcin Gradziel, S. Dheilly, François Pajot, A.C. Cobos Cerutti, C. Chapron, A. Fasciszewski, J.-Ch. Hamilton, M. González, M. Tomasi, Créidhe O'Sullivan, Laurent Bergé, G. Amico, D. Buzi, A.D. Supanitsky, D. Auguste, Gianluca Polenta, Francesco Cavaliere, P. Ringegni, G. Stankowiak, Luca Lamagna, Steve Torchinsky, L. Mele, Andrew May, Peter Timbie, F. Columbro, F. Voisin, C. Tucker, J. Kaplan, B. Bélier, R. Charlassier, M. R. Hampel, G. de Gasperis, C. Scóccola, Lucio Piccirillo, Thibaut Louis, Sophie Henrot-Versille, D. Melo, J.-Ph. Bernard, M. Stolpovskiy, Y. Giraud-Héraud, M. De Leo, M. De Petris, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Zmuidzinas, Jonas, Gao, Jian-Rong, Stankowiak, G, Piat, M, Battistelli, E, D'Alessandro, G, de Bernardis, P, De Petris, M, González, M, Grandsire, L, Hamilton, J, Hoang, T, Masi, S, Marnieros, S, Mennella, A, Mousset, L, O'Sullivan, C, Prêle, D, Tartari, A, Thermeau, J, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Bélier, B, Baù, A, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, de Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Héraud, Y, Gómez Berisso, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Rasztocky, E, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stolpovskiy, M, Supanitsky, A, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Wicek, F, Wright, M, and Zullo, A
Subjects: QUBIC, Cosmic microwave background, 02 engineering and technology, CMB, SQUID, 7. Clean energy, Superconducting QUantum Interference Device, 030218 nuclear medicine & medical imaging, law.invention, TDM, FIS/05 - ASTRONOMIA E ASTROFISICA, 03 medical and health sciences, 020210 optoelectronics & photonics, 0302 clinical medicine, Optics, Application-specific integrated circuit, law, Cosmic Microwave Background, B-modes, 0202 electrical engineering, electronic engineering, information engineering, Noise-equivalent power, [PHYS]Physics [physics], Physics, TES, business.industry, Bolometer, Time constant, CMB instrumentation, bolometric interferometry, Transition Edge Sensor, Interferometry, Transition edge sensor, business
Abstract: International audience; The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10-16W= p √Hz
Published: 2020

13. Architectural design and prototype for the logging, monitoring, and alarm system for the ASTRI mini-array

Author: Federico Russo, Pietro Bruno, Eva Sciacca, Andrea Bulgarelli, Stefano Germani, Alessandro Grillo, Fulvio Gianotti, F. Incardona, Kevin Munari, Antonio Calanducci, Joseph Schwarz, Gino Tosti, Alessandro Costa, Vito Conforti, and Fabio Vitello
Subjects: Software, business.industry, Observatory, Computer science, Scale (chemistry), Big data, Logging, Scalability, Systems engineering, Systems architecture, Relevance (information retrieval), business
Abstract: Large volumes of monitoring and logging data result from the operation of a large scale astrophysical observatory. In the last few years several “Big Data” technologies have been developed to deal with such volumes of data especially in the Internet of Things (IoT) framework. We present the logging, monitoring and alarm system architecture for the ASTRI Mini-Array aimed at supporting the analysis of scientific data and improving the operational activities of the telescope facility . A prototype was designed and built considering the latest software tools and concepts coming from Big Data and IoT and a particular relevance has been given in satisfying quality requirements such as performance, scalability and availability.
Published: 2020

14. TES Bolometer Arrays for the QUBIC B-Mode CMB Experiment

Author: F. Piacentini, S. Loucatos, A. Zullo, C. Oriol, J.-Ch. Hamilton, Silvia Masi, Peter Timbie, F. Columbro, P. A. R. Ade, Francesco Cavaliere, S. Azzoni, M. Gómez Berisso, G. Amico, J. G. Alberro, D. Buzi, A. Bottani, A. Passerini, J. Bonis, Steve Torchinsky, V. Gilles, A. Pelosi, J. Aumont, Nicola Vittorio, B. Maffei, C. Chapron, Michel Piat, J. Bonaparte, Bruce Rafael Mellado Garcia, E. Olivieri, Alessandro Coppolecchia, Giampaolo Pisano, François Pajot, A. Fasciszewski, Luca Lamagna, Emory F. Bunn, Alejandro Almela, M. E. García Redondo, M. Platino, L. M. Mundo, W. Marty, R. Charlassier, J.-P. Thermeau, C. Kristukat, Federico Pezzotta, S. Marnieros, J. Kaplan, D. Fracchia, Andrea Tartari, A. Mattei, G. de Gasperis, M. De Leo, D. T. Hoang, Y. Giraud-Heraud, B. Bélier, P. Ringegni, M. De Petris, N. Bleurvacq, Massimo Gervasi, Cristian Franceschet, G. Stankowiak, E. Jules, Andrew May, Gustavo E. Romero, F. Incardona, Marcin Gradziel, J.M. Salum, S. Dheilly, L. Mele, P. de Bernardis, H. Pastoriza, D. Harari, F. Voisin, P. Battaglia, Alessandro Schillaci, S. Spinelli, L.P. Ferreyro, M. Gaspard, M. Tomasi, A. Etchegoyen, Marco Bersanelli, D. Viganò, Mario Zannoni, D. Prêle, S. Scully, A. Mennella, M. M. Gamboa Lerena, Créidhe O'Sullivan, Laurent Bergé, Gianluca Polenta, D. Bennett, J. D. Murphy, M. González, Alessandro Paiella, Damien Rambaud, F. Wicek, Mark McCulloch, Lucio Piccirillo, Thibaut Louis, Sophie Henrot-Versille, J.-Ph. Bernard, M. Stolpovskiy, D. Burke, C. Perbost, J. A. Murphy, P. Chanial, L. A. Montier, Roberto Puddu, Elia S. Battistelli, D. Gayer, S. Banfi, Gregory S. Tucker, L. Grandsire, Giuseppe D'Alessandro, Martin Giard, M.-A. Bigot-Sazy, Federico Nati, M. Perciballi, L. Dumoulin, L. H. Arnaldi, Simon J. Melhuish, A. Baù, L. Mousset, Maria Salatino, D. Auguste, C. Scóccola, Carole Tucker, K. Ganga, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Marnieros, S, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Battaglia, P, Battistelli, E, Bau, A, Belier, B, Bennett, D, Berge, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bleurvacq, N, Bonaparte, J, Bonis, J, Bottani, A, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Columbro, F, Coppolecchia, A, D'Alessandro, G, de Bernardis, P, De Gasperis, G, De Leo, M, De Petris, M, Dheilly, S, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, Garcia, B, Garcia Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gomez Berisso, M, Gonzalez, M, Gradziel, M, Grandsire, L, Hamilton, J, Harari, D, Henrot-Versille, S, Hoang, D, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Masi, S, Mattei, A, May, A, Mcculloch, M, Mele, L, Melhuish, S, Mennella, A, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, O'Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piat, M, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prele, D, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Salatino, M, Salum, J, Schillaci, A, Scoccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Torchinsky, S, Tucker, G, Tucker, C, Vigano, D, Vittorio, N, Voisin, F, Wicek, F, Zannoni, M, and Zullo, A
Subjects: Fabrication, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Cosmic microwave background, Cryogenic detector, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 010305 fluids & plasmas, law.invention, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, law, 0103 physical sciences, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, ComputingMilieux_MISCELLANEOUS, Physics, business.industry, Settore FIS/05, Transition edge sensors, Bolometer, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Polarization (waves), Atomic and Molecular Physics, and Optics, Interferometry, Cryogenic detectors, business
Abstract: International audience; QUBIC is a ground-based experiment aiming to measure the B-mode polarization of the cosmic microwave background. The developed instrument is an innovative two-frequency band bolometric interferometer that will operate at 300 mK with NbSi TES arrays. In this paper, we describe the fabrication process of the detectors.
Published: 2020

15. Calibration of QUBIC: The Q and U bolometric interferometer for cosmology

Author: D. Melo, Peter T. Timbie, G. Polenta, L. Mele, S. Loucatos, K. Ganga, Alejandro Almela, Luca Lamagna, W. Marty, Gustavo E. Romero, Giuseppe D'Alessandro, D. Burke, Emory F. Bunn, H. Pastoriza, D. Harari, L. Montier, E. Rasztocky, F. Piacentini, C. Duca, L.P. Ferreyro, L. M. Mundo, D. Prêle, Andrew May, C. Perbost, J.-Ph. Bernard, M. Stolpovskiy, P. de Bernardis, Francesco Cavaliere, J. A. Murphy, P. A. R. Ade, M. Platino, Federico Nati, Créidhe O'Sullivan, M. Wright, Cristian Franceschet, M. Gómez Berisso, M. Giard, M. Gaspard, P. Chanial, E. Olivieri, Alessandro Schillaci, D. Fracchia, C. Kristukat, Y. Giraud-Héraud, A. Baù, L. Mousset, J. Kaplan, C. Oriol, A. Mattei, F. Columbro, J. Bonaparte, M. E. García Redondo, B. Bélier, Nicola Vittorio, L. Grandsire, Silvia Masi, J. Bonis, C. Tucker, G. Amico, Federico Pezzotta, M. Piat, J.-P. Thermeau, F. Incardona, D. Buzi, A. Mennella, Marcin Gradziel, A.D. Supanitsky, J. D. Murphy, Gregory S. Tucker, E. Jules, A. Passerini, V. Gilles, J.M. Salum, S. Dheilly, M. Perciballi, M. M. Gamboa Lerena, F. Voisin, S. A. Torchinsky, Alessandro Paiella, Damien Rambaud, Bruno Maffei, J.G. Alberro, A.C. Cobos Cerutti, C. Chapron, L. Bergé, Mark McCulloch, S. Marnieros, S. Azzoni, D. Auguste, Giampaolo Pisano, F. Pajot, F. Wicek, R. Puddu, Elia S. Battistelli, D. Gayer, S. Banfi, L. H. Arnaldi, J. Aumont, Massimo Gervasi, M. De Leo, D. Bennett, A. Zullo, S. Spinelli, M. Tomasi, Lucio Piccirillo, C. Scóccola, M. De Petris, A. Etchegoyen, Thibaut Louis, Marco Bersanelli, Sophie Henrot-Versille, Mario Zannoni, M.-A. Bigot-Sazy, M. González, A. Pelosi, S. Scully, P. Ringegni, G. Stankowiak, J.-Ch. Hamilton, L. Dumoulin, A. Tartari, D. Viganò, R. Charlassier, M. R. Hampel, G. de Gasperis, Bruce Rafael Mellado Garcia, Alessandro Coppolecchia, A. Fasciszewski, Zmuidzinas, Jonas, Murphy, J, Burke, D, Gamboa Lerena, M, Hamilton, J, Mousset, L, De Petris, M, O'Sullivan, C, Torchinsky, S, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Bélier, B, Battistelli, E, Baù, A, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, D'Alessandro, G, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Grandsire, L, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Mennella, A, Montier, L, Mundo, L, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Voisin, F, Wicek, F, Wright, M, Zannoni, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), and Gao, Jian-Rong
Subjects: QUBIC, Instrumentation, interferometer, Cosmic microwave background, measurement methods, CDM, cosmic background radiation: polarization, 02 engineering and technology, Astrophysics::Cosmology and Extragalactic Astrophysics, CMB, 7. Clean energy, 01 natural sciences, Cosmology, law.invention, 010309 optics, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, bolometer, B-mode polarisation, law, 0103 physical sciences, Cosmic Microwave Background, Calibration, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], measure: spectral, detector: design, data-analysis, Physics, instrumentation, calibration, TES, business.industry, Instrument Data, Bolometer, transition edge sensor, Astrophysics::Instrumentation and Methods for Astrophysics, 021001 nanoscience & nanotechnology, sensitivity, Interferometry, B-mode, Transition edge sensor, 0210 nano-technology, business
Abstract: International audience; QUBIC (a Q and U Bolometric Interferometer for Cosmology) is a next generation cosmology experiment designed to detect the B-mode polarisation of the Cosmic Microwave Background (CMB). A B-mode detection is hard evidence of Inflation in the ΛCDM model. QUBIC aims to accomplish this by combining novel technologies to achieve the sensitivity required to detect the faint B-mode signal. QUBIC uses technologies such as a rotating half-wave plate, cryogenics, interferometric horns with self-calibration switches and transition edge sensor bolometers. A Technical Demonstrator (TD) is currently being calibrated in APC in Paris before observations in Argentina in 2021. As part of the calibration campaign, the spectral response of the TD is measured to test and validate QUBIC's spectro-imaging capability. This poster gives an overview of the methods used to measure the spectral response and a comparison of the instrument data with theoretical predictions and optical simulations.
Published: 2020

16. QUBIC: the Q \& U Bolometric Interferometer for Cosmology

Author: E. S. Battistelli, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, S. Banfi, P. Battaglia, A. Baù, B. Bélier, D. Bennett, L. Bergé, J.-Ph. Bernard, M. Bersanelli, M.-A. Bigot-Sazy, N. Bleurvacq, J. Bonaparte, J. Bonis, A. Bottani, E. Bunn, D. Burke, D. Buzi, A. Buzzelli, F. Cavaliere, P. Chanial, C. Chapron, R. Charlassier, F. Columbro, G. Coppi, A. Coppolecchia, G. D’Alessandro, P. de Bernardis, G. De Gasperis, M. De Leo, M. De Petris, S. Dheilly, A. Di Donato, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, C. Franceschet, M. M. Gamboa Lerena, K. Ganga, B. García, M. E. García Redondo, M. Gaspard, A. Gault, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. Gómez Berisso, M. González, M. Gradziel, L. Grandsire, J.-Ch. Hamilton, D. Harari, V. Haynes, S. Henrot-Versillé, D. T. Hoang, F. Incardona, E. Jules, J. Kaplan, A. Korotkov, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, R. Luterstein, B. Maffei, S. Marnieros, W. Marty, S. Masi, A. Mattei, A. May, M. McCulloch, M. C. Medina, L. Mele, S. Melhuish, A. Mennella, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, C. O’Sullivan, A. Paiella, F. Pajot, A. Passerini, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Pezzotta, F. Piacentini, M. Piat, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, P. Ringegni, G. E. Romero, M. Salatino, J. M. Salum, A. Schillaci, C. Scóccola, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, F. Suarez, A. Tartari, J.-P. Thermeau, P. Timbie, M. Tomasi, S. Torchinsky, M. Tristram, C. Tucker, G. Tucker, S. Vanneste, D. Viganò, N. Vittorio, F. Voisin, B. Watson, F. Wicek, M. Zannoni, A. Zullo, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), QUBIC, Battistelli, E, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Battaglia, P, Bau, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bleurvacq, N, Bonaparte, J, Bonis, J, Bottani, A, Bunn, E, Burke, D, Buzi, D, Buzzelli, A, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Columbro, F, Coppi, G, Coppolecchia, A, D’Alessandro, G, de Bernardis, P, De Gasperis, G, De Leo, M, De Petris, M, Dheilly, S, Di Donato, A, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Lerena, M, Ganga, K, García, B, Redondo, M, Gaspard, M, Gault, A, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Berisso, M, González, M, Gradziel, M, Grandsire, L, Hamilton, J, Harari, D, Haynes, V, Henrot-Versillé, S, Hoang, D, Incardona, F, Jules, E, Kaplan, J, Korotkov, A, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Luterstein, R, Maffei, B, Marnieros, S, Marty, W, Masi, S, Mattei, A, May, A, Mcculloch, M, Medina, M, Mele, L, Melhuish, S, Mennella, A, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, O’Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piat, M, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Salatino, M, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Suarez, F, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Torchinsky, S, Tristram, M, Tucker, C, Tucker, G, Vanneste, S, Viganò, D, Vittorio, N, Voisin, F, Watson, B, Wicek, F, Zannoni, M, Zullo, A, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Zmuidzinas, J, Gao, JR, De Bernardis, P, Dalessandro, G, Hoang, T, Osullivan, C, Prele, D, Belier, B, Berge, L, Cobos Cerutti, A, Duca, C, Gamboa Lerena, M, Garcia, B, Garcia Redondo, M, Gomez Berisso, M, Gonzalez, M, Hampel, M, Henrot-Versille, S, Melo, D, Olivicri, E, Rasztocky, E, Scoccola, C, Supanitsky, A, Vigano, D, Wright, M, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)
Subjects: cosmological model, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Ciencias Físicas, electormagnetics, cosmic background radiation: polarization, cosmic background radiation, Cosmic microwave background, cosmology, gravitational waves, polarization, bolometric interferometer, stokes polarimeter, transition-edge sensors, 01 natural sciences, Stokes polarimeter, purl.org/becyt/ford/1 [https], SPIE Proceeding, Polarization, propagation, ultraviolet, optical, site, General Materials Science, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Microwave measurement, Settore FIS/05, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Cosmology, physical optics, Optical interferometry, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Cosmic Microwave Background, Polarization, Cosmology, Experimental, Astrophysics - Instrumentation and Methods for Astrophysics, CIENCIAS NATURALES Y EXACTAS, signature, Manuscript format, Astrophysics - Cosmology and Nongalactic Astrophysics, Transition-edge sensors, Cosmology and Nongalactic Astrophysics (astro-ph.CO), detector: cryogenics, LaTeX, interferometer, FOS: Physical sciences, anisotropy, Astrophysics::Cosmology and Extragalactic Astrophysics, microwaves, Gravitational waves, FIS/05 - ASTRONOMIA E ASTROFISICA, bolometer, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], inflation, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Ultraviolet sources, Q measurement, beam propagation, Template, Bolometric interferometer, purl.org/becyt/ford/1.3 [https], Optical propagation, sensitivity, optics, Optical polarization, Astronomía, Instruments, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: The Q & U Bolometric Interferometer for Cosmology, QUBIC, is an innovative experiment designed to measure the polarization of the Cosmic Microwave Background and in particular the signature left therein by the inflationary expansion of the Universe. The expected signal is extremely faint, thus extreme sensitivity and systematic control are necessary in order to attempt this measurement. QUBIC addresses these requirements using an innovative approach combining the sensitivity of Transition Edge Sensor cryogenic bolometers, with the deep control of systematics characteristic of interferometers. This makes QUBIC unique with respect to others classical imagers experiments devoted to the CMB polarization. In this contribution we report a description of the QUBIC instrument including recent achievements and the demonstration of the bolometric interferometry performed in lab. QUBIC will be deployed at the observation site in Alto Chorrillos, in Argentina at the end of 2019., Accepted for publication in the Journal of Low Temperature Physics
Published: 2019

17. QUBIC: using NbSi TESs with a bolometric interferometer to characterize the polarisation of the CMB

Author: Alejandro Almela, L. H. Arnaldi, W. Marty, S. Loucatos, Andrea Tartari, A. Pelosi, J. Aumont, Massimo Gervasi, K. Ganga, Emory F. Bunn, L. Grandsire, Giuseppe D'Alessandro, L. M. Mundo, E. Jules, Victor Haynes, S. Marnieros, C. Chapron, L. Mele, M. Platino, C. Kristukat, D. Fracchia, M. C. Medina, F. Piacentini, A. Gault, D. Prêle, D. T. Hoang, Andrei Korotkov, A. Mattei, M. Gaspard, Damien Rambaud, P. A. R. Ade, Gustavo E. Romero, M. Tomasi, Federico Pezzotta, Y. Giraud-Heraud, S. Vanneste, S. Banfi, J. Bonaparte, A. Etchegoyen, Martin Giard, Marco Bersanelli, Elia S. Battistelli, J.-Ph. Bernard, M. Stolpovskiy, D. Gayer, P. de Bernardis, Marcin Gradziel, F. Wicek, J. Kaplan, M. Gómez Berisso, R. Charlassier, J.G. Alberro, Mark McCulloch, F. Incardona, Asdrúbal Enrique Bottani, Mario Zannoni, Peter Timbie, B. Bélier, V. Gilles, F. Columbro, Luca Lamagna, M. E. García Redondo, M.-A. Bigot-Sazy, A. Zullo, Giampaolo Pisano, S. Scully, Nicola Vittorio, N. Bleurvacq, J.M. Salum, S. Dheilly, Lucio Piccirillo, D. Burke, F. Suarez, A. Passerini, J. Bonis, G. de Gasperis, Maria Salatino, D. Auguste, R. Luterstein, Thibaut Louis, Sophie Henrot-Versille, J. D. Murphy, Gregory S. Tucker, C. Perbost, J. A. Murphy, B. Maffei, P. Chanial, L. A. Montier, Michel Piat, F. Voisin, Alessandro Schillaci, Alessandro Paiella, Roberto Puddu, E. Olivieri, C. Scóccola, Carole Tucker, Andrew May, Bruce Rafael Mellado Garcia, Alessandro Coppolecchia, H. Pastoriza, D. Harari, L. Dumoulin, G. Amico, J.-P. Thermeau, D. Buzi, François Pajot, C. Oriol, M. De Leo, L.P. Ferreyro, Cristian Franceschet, A. Fasciszewski, Alessandro Buzzelli, M. De Petris, S. Spinelli, J.-Ch. Hamilton, Federico Nati, B. Watson, Francesco Cavaliere, M. Perciballi, S. Azzoni, Silvia Masi, A. Di Donato, Créidhe O'Sullivan, Laurent Bergé, D. Viganò, Gabriele Coppi, Steve Torchinsky, Gianluca Polenta, Simon J. Melhuish, A. Baù, L. Mousset, P. Ringegni, G. Stankowiak, A. Mennella, M. M. Gamboa Lerena, D. Bennett, M. González, P. Battaglia, Piat, M, Bélier, B, Bergé, L, Bleurvacq, N, Chapron, C, Dheilly, S, Dumoulin, L, González, M, Grandsire, L, Hamilton, J, Henrot-Versillé, S, Hoang, D, Marnieros, S, Marty, W, Montier, L, Olivieri, E, Oriol, C, Perbost, C, Prêle, D, Rambaud, D, Salatino, M, Stankowiak, G, Thermeau, J, Torchinsky, S, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Battaglia, P, Battistelli, E, Baù, A, Bennett, D, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bottani, A, Bunn, E, Burke, D, Buzi, D, Buzzelli, A, Cavaliere, F, Chanial, P, Charlassier, R, Columbro, F, Coppi, G, Coppolecchia, A, D’Alessandro, G, de Bernardis, P, De Gasperis, G, De Leo, M, De Petris, M, Di Donato, A, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gault, A, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, Gradziel, M, Harari, D, Haynes, V, Incardona, F, Jules, E, Kaplan, J, Korotkov, A, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Luterstein, R, Maffei, B, Masi, S, Mattei, A, May, A, Mcculloch, M, Medina, M, Mele, L, Melhuish, S, Mennella, A, Mousset, L, Mundo, L, Murphy, J, Nati, F, O’Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Puddu, R, Ringegni, P, Romero, G, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stolpovskiy, M, Suarez, F, Tartari, A, Timbie, P, Tomasi, M, Tucker, C, Tucker, G, Vanneste, S, Viganò, D, Vittorio, N, Watson, B, Wicek, F, Zannoni, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), TESs, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Physics::Instrumentation and Detectors, Cosmic microwave background, FOS: Physical sciences, Integrated circuit, CMB, TDM, 01 natural sciences, Multiplexing, Cosmology, 010305 fluids & plasmas, law.invention, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, law, 0103 physical sciences, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], Physics, business.industry, Cosmology, Instrumentation, Polarization, Cosmic Microwave Background, Cryogenics, Bolometers, Detector, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Polarization (waves), Atomic and Molecular Physics, and Optics, Interferometry, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Instrumentation and Methods for Astrophysics, business, TES, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: QUBIC (Q \& U Bolometric Interferometer for Cosmology) is an international ground-based experiment dedicated in the measurement of the polarized fluctuations of the Cosmic Microwave Background (CMB). It is based on bolometric interferometry, an original detection technique which combine the immunity to systematic effects of an interferometer with the sensitivity of low temperature incoherent detectors. QUBIC will be deployed in Argentina, at the Alto Chorrillos mountain site near San Antonio de los Cobres, in the Salta province. The QUBIC detection chain consists in 2048 NbSi Transition Edge Sensors (TESs) cooled to 350mK.The voltage-biased TESs are read out with Time Domain Multiplexing based on Superconducting QUantum Interference Devices (SQUIDs) at 1 K and a novel SiGe Application-Specific Integrated Circuit (ASIC) at 60 K allowing to reach an unprecedented multiplexing (MUX) factor equal to 128. The QUBIC experiment is currently being characterized in the lab with a reduced number of detectors before upgrading to the full instrument. I will present the last results of this characterization phase with a focus on the detectors and readout system., Conference proceedings submitted to the Journal of Low Temperature Physics for LTD18
Published: 2019
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18. Preliminary scanning strategy analysis for the LSPE-STRIP instrument

Author: M. Tomasi, Marco Bersanelli, S. Realini, F. Incardona, Cristian Franceschet, Marco Benetti, A. Mennella, and Davide Maino
Subjects: 010504 meteorology & atmospheric sciences, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, Astrophysics::Instrumentation and Methods for Astrophysics, Northern Hemisphere, Astrophysics::Cosmology and Extragalactic Astrophysics, Polarization (waves), 01 natural sciences, law.invention, Azimuth, Telescope, Crab Nebula, Observatory, law, Sky, 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Geology, 0105 earth and related environmental sciences, Remote sensing, Earth's rotation, media_common
Abstract: We present a preliminary study of the sky scanning strategy for the LSPE-STRIP instrument, a ground-based telescope that will be installed at the Teide Observatory (Tenerife, Canary Islands) in early 2019 and will observe the polarized emission of about 25% of the sky in the Northern Hemisphere at 43 and 95 GHz. The same sky portion will be observed at 140, 220 and 240 GHz by LSPE-SWIPE, a stratospheric balloon scheduled for a long-duration flight around the North Pole during the Arctic winter of 2019/2020. The combination of data from the two instruments aims at constraining the tensor-to-scalar ratio down to r ~ 0.03. In our paper we discuss the main scanning strategy requirements (overlap with SWIPE coverage, sensitivity distribution, observation of calibration sources) and show how we obtain a trade-off by spinning the telescope around the azimuth axis with constant elevation and angular velocity. The combination of the telescope motion with the Earth rotation will guarantee the access to the large angular scales. We will observe periodically the Crab Nebula as well as the Perseus molecular cloud. The Crab is one of the best known polarized sources in the sky and it will be observed for calibration purposes. The second one is a source of Anomalous Microwave Emission that could be characterized both in intensity and polarization.
Published: 2018

19. Simulations and performance of the QUBIC optical beam combiner

Author: Emory F. Bunn, M.-A. Bigot-Sazy, Y. Giraud-Héraud, A. Zullo, Alessandro Buzzelli, M. Gómez Berisso, M. Giard, F. Voisin, J. Aumont, L. Mele, N. Bleurvacq, L. Dumoulin, L. Grandsire, Nicola Vittorio, Giuseppe D'Alessandro, P. Ringegni, F. Piacentini, Peter T. Timbie, P. Chanial, D. Viganò, M. C. Medina, Alessandro Schillaci, Créidhe O'Sullivan, Laurent Bergé, G. Polenta, Gabriele Coppi, Steve Torchinsky, P. Battaglia, L. Montier, X. Garrido, J.-P. Thermeau, Massimo Gervasi, V. Truongcanh, Rocco D'Agostino, M. Gaspard, R. Puddu, J. Bonaparte, Luca Lamagna, S. Spinelli, C. Chapron, G. de Gasperis, Victor Haynes, A. Etchegoyen, S. Loucatos, Gregory S. Tucker, L. M. Mundo, Marco Bersanelli, A. Lowitz, G. Bordier, E. Guerrard, Mario Zannoni, A. Pelosi, G. Amico, Vladimir V. Luković, D. Buzi, E. Olivieri, R. Luterstein, S. Scully, D. Prêle, H. Pastoriza, A. Mattei, J. Kaplan, F. Columbro, A. Gault, A. Passerini, F. Pajot, D. Harari, Silvia Masi, A. Di Donato, B. Watson, M. Stolpovskiy, Gustavo E. Romero, E. Bréelle, R. Charlassier, J. Bonis, Elia S. Battistelli, D. Gayer, M. De Leo, A. Tartari, Peter A. R. Ade, J. D. Murphy, B. Bélier, S. Banfi, Alessandro Paiella, P. de Bernardis, S. Vanneste, Andrew May, M. De Petris, G. Barbarán, Giampaolo Pisano, Francesco Cavaliere, Cristian Franceschet, D. T. Hoang, Matthieu Tristram, D. Burke, F. Incardona, F. Suarez, J. A. Murphy, C. Kristukat, Marcin Gradziel, F. Couchot, Bruce Rafael Mellado Garcia, A. Mennella, Alessandro Coppolecchia, M. M. Gamboa Lerena, Andrei Korotkov, A. Fasciszewski, D. Bennett, Damien Rambaud, M. González, Bruno Maffei, F. Wicek, Mark McCulloch, S. Marnieros, O. Perdereau, Maria Salatino, D. Auguste, J.-Ch. Hamilton, C. Perbost, C. Scóccola, Carole Tucker, Federico Pezzotta, M. Piat, E. Jules, Lucio Piccirillo, Thibaut Louis, Sophie Henrot-Versille, Simon J. Melhuish, A. Baù, J.-Ph. Bernard, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Zmuidzinas, Jonas, Gao, Jian-Rong, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Zmuidzinas, J, Gao, JR, Zullo, A, Wicek, F, Watson, B, Voisin, F, Vittorio, N, Viganò, D, Vanneste, S, Tucker, G, Tucker, C, Truongcanh, V, Tristram, M, Torchinsky, S, Timbie, P, Thermeau, J, Tartari, A, Suarez, F, Stolpovskiy, M, Spinelli, S, Scóccola, C, Schillaci, A, Salatino, M, Romero, G, Ringegni, P, Rambaud, D, Puddu, R, Prêle, D, Polenta, G, Pisano, G, Piccirillo, L, Piat, M, Piacentini, F, Pezzotta, F, Perdereau, O, Perbost, C, Pelosi, A, Pastoriza, H, Passerini, A, Pajot, F, Paiella, A, Olivieri, E, Murphy, J, Mundo, L, Montier, L, Melhuish, S, Medina, M, Mele, L, Mcculloch, M, May, A, Mattei, A, Masi, S, Marnieros, S, Maffei, B, Luterstein, R, Lukovic, V, Lowitz, A, Louis, T, Loucatos, S, Lamagna, L, Kristukat, C, Korotkov, A, Kaplan, J, Jules, E, Incardona, F, Hoang, D, Henrot-Versillé, S, Haynes, V, Harari, D, Grandsire, L, Gradziel, M, González, M, Gómez Berisso, M, Giraud-Héraud, Y, Giard, M, Gervasi, M, Gault, A, Gaspard, M, Garrido, X, García, B, Gamboa Lerena, M, Franceschet, C, Fasciszewski, A, Etchegoyen, A, Dumoulin, L, Di Donato, A, de Gasperis, G, de Bernardis, P, D’Alessandro, G, D'Agostino, R, Couchot, F, Coppolecchia, A, Coppi, G, Columbro, F, Charlassier, R, Chapron, C, Chanial, P, Cavaliere, F, Buzzelli, A, Buzi, D, Bunn, E, Bréelle, E, Bordier, G, Bonis, J, Bonaparte, J, Bleurvacq, N, Bigot-Sazy, M, Bersanelli, M, Bernard, J, Bergé, L, Bennett, D, Bélier, B, Baù, A, Battistelli, E, Battaglia, P, Barbarán, G, Banfi, S, Aumont, J, Auguste, D, Amico, G, Ade, P, Hamilton, J, Zannoni, M, Mennella, A, De Leo, M, De Petris, M, Scully, S, Guerrard, E, Gayer, D, Burke, D, and O'Sullivan, C
Subjects: cosmological model, higher-order, QUBIC, Cosmic microwave background, CMB, Interference (wave propagation), 01 natural sciences, 7. Clean energy, Cosmology, B-mode: primordial, law.invention, law, B-modes, Anisotropy, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Physics, Applied Mathematics, Astrophysics::Instrumentation and Methods for Astrophysics, Computer Science Applications1707 Computer Vision and Pattern Recognition, bolometric interferometry, Condensed Matter Physics, Physical optics, physical optics, Interferometry, Horn antenna, detector: performance, polarization: anisotropy, Astrophysics::High Energy Astrophysical Phenomena, interferometer, interference, Astrophysics::Cosmology and Extragalactic Astrophysics, model: optical, programming, 010309 optics, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, 0103 physical sciences, Electronic, Optical and Magnetic Materials, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Electrical and Electronic Engineering, Astrophysics::Galaxy Astrophysics, Millimeter, Submillimeter, Far-Infrared, Detectors, Instrumentation, Cosmic Microwave Background, Polarization, business.industry, Bolometer, gravitational radiation: primordial, optics, detector: sensitivity, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Electronic, Optical and Magnetic Materials, cosmic background radiation: anisotropy
Abstract: QUBIC, the Q & U Bolometric Interferometer for Cosmology, is a novel ground-based instrument that aims to measure the extremely faint B-mode polarisation anisotropy of the cosmic microwave background at intermediate angular scales (multipoles of = 30 − 200). Primordial B-modes are a key prediction of Inflation as they can only be produced by gravitational waves in the very early universe. To achieve this goal, QUBIC will use bolometric interferometry, a technique that combines the sensitivity of an imager with the immunity to systematic effects of an interferometer. It will directly observe the sky through an array of back-to-back entry horns whose beams will be superimposed using a cooled quasioptical beam combiner. Images of the resulting interference fringes will be formed on two focal planes, each tiled with transition-edge sensors, cooled down to 320 mK. A dichroic filter placed between the optical combiner and the focal planes will select two frequency bands (centred at 150 GHz and 220 GHz), one frequency per focal plane. Polarization modulation will be achieved using a cold stepped half-wave plate (HWP) and polariser in front of the sky-facing horns. The full QUBIC instrument is described elsewhere1,2,3,4; in this paper we will concentrate in particular on simulations of the optical combiner (an off-axis Gregorian imager) and the feedhorn array. We model the optical performance of both the QUBIC full module and a scaled-down technological demonstrator which will be used to validate the full instrument design. Optical modelling is carried out using full vector physical optics with a combination of commercial and in-house software. In the high-frequency channel we must be careful to consider the higher-order modes that can be transmitted by the horn array. The instrument window function is used as a measure of performance and we investigate the effect of, for example, alignment and manufacturing tolerances, truncation by optical components and off-axis aberrations. We also report on laboratory tests carried on the QUBIC technological demonstrator in advance of deployment to the observing site in Argentina.
Published: 2018

20. Performance of NbSi transition-edge sensors readout with a 128 MUX factor for the QUBIC experiment

Author: L. M. Mundo, M. Gómez Berisso, M. Giard, A. Tartari, Nicola Vittorio, A. Mattei, F. Columbro, R. Charlassier, L. Grandsire, A. Mennella, A. Pelosi, M. M. Gamboa Lerena, D. Bennett, Andrei Korotkov, M. González, F. Piacentini, D. Burke, C. Perbost, J. A. Murphy, P. Chanial, E. Olivieri, Damien Rambaud, B. Watson, Giampaolo Pisano, N. Bleurvacq, Maria Salatino, D. Auguste, H. Pastoriza, D. Harari, G. Barbarán, Bruno Maffei, F. Wicek, F. Couchot, L. Dumoulin, Peter A. R. Ade, J. Bonaparte, Giuseppe D'Alessandro, S. Loucatos, A. Gault, A. Lowitz, P. Battaglia, Mark McCulloch, S. Marnieros, P. Ringegni, A. Zullo, G. Amico, D. Viganò, S. Banfi, C. Scóccola, Carole Tucker, Créidhe O'Sullivan, Laurent Bergé, Andrew May, D. Buzi, M. C. Medina, L. Mele, J.-Ph. Bernard, M. Stolpovskiy, M. Piat, Emory F. Bunn, M.-A. Bigot-Sazy, F. Voisin, Bruce Rafael Mellado Garcia, C. Kristukat, O. Perdereau, S. Maestre, Y. Giraud-Héraud, J. D. Murphy, F. Incardona, Alessandro Coppolecchia, F. Suarez, Peter T. Timbie, C. Chapron, Alessandro Schillaci, Alessandro Paiella, W. Marty, G. Polenta, E. Bréelle, A. Fasciszewski, J. Aumont, R. Puddu, S. Spinelli, L. Montier, D. T. Hoang, Massimo Gervasi, Federico Pezzotta, F. Pajot, Elia S. Battistelli, D. Gayer, Simon J. Melhuish, V. Truongcanh, A. Baù, M. Gaspard, J.-P. Thermeau, Luca Lamagna, A. Etchegoyen, Marcin Gradziel, A. Buzzelli, Francesco Cavaliere, Lucio Piccirillo, Marco Bersanelli, J. Kaplan, Mario Zannoni, D. Prêle, Thibaut Louis, Sophie Henrot-Versille, A. Passerini, G. De Gasperis, B. Bélier, S. Scully, S. Vanneste, Victor Haynes, Gregory S. Tucker, M. De Leo, R. Luterstein, M. De Petris, Gustavo E. Romero, P. de Bernardis, J.-Ch. Hamilton, Rocco D'Agostino, E. Jules, Gabriele Coppi, Steve Torchinsky, Silvia Masi, A. Di Donato, X. Garrido, E. Guerrard, Vladimir V. Luković, G. Bordier, Cristian Franceschet, Matthieu Tristram, J. Bonis, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Zmuidzinas, J, Gao, JR, Salatino, M, Suarez, F, Bennett, D, Murphy, J, Ade, P, Thermeau, J, Zullo, A, Zannoni, M, Wicek, F, Watson, B, Vittorio, N, Viganò, D, Vanneste, S, Tucker, G, Tucker, C, Truongcanh, V, Tristam, M, Timbie, P, Tartari, A, Stolpovskiy, M, Spinelli, S, Scully, S, Scóccola, C, Schillaci, A, Romero, G, Ringegni, P, Puddu, R, Polenta, G, Pisano, G, Piccirillo, L, Piacentini, F, Pezzotta, F, Perdereau, O, Perbost, C, Pelosi, A, Pastoriza, H, Passerini, A, Pajot, F, Paiella, A, Olivieri, E, O'Sullivan, C, Mundo, L, Mennella, A, Melhuish, S, Mele, L, Medina, M, Mcculloch, M, May, A, Mattei, A, Masi, S, Maffei, B, Luterstein, R, Lukovic, V, Lowitz, A, Louis, T, Loucatos, S, Lamagna, L, Kristukat, C, Korotkov, A, Kaplan, J, Jules, E, Incardona, F, Haynes, V, Harari, D, Hamilton, J, Guerrard, E, Grandsire, L, Gradziel, M, González, M, Gómez Berisso, M, Giraud-Héraud, Y, Giard, M, Gervasi, M, Gayer, D, Gault, A, Gaspard, M, Garrido, X, García, B, Gamboa, M, Franceschet, C, Fasciszewski, A, Etchegoyen, A, Dumoulin, L, Di Donato, A, De Petris, M, De Leo, M, de Gasperis, G, de Bernardis, P, D’Alessandro, G, D'Agostino, R, Couchot, F, Coppolecchia, A, Coppi, G, Columbro, F, Charlassier, R, Chanial, P, Cavaliere, F, Buzzelli, A, Buzi, D, Burke, D, Bunn, E, Bréelle, E, Bordier, G, Bonis, J, Bonaparte, J, Bleurvacq, N, Bigot-Sazy, M, Bersanelli, M, Bernard, J, Bergé, L, Baù, A, Battistelli, E, Battaglia, P, Barbarán, G, Banfi, S, Aumont, J, Auguste, D, Amico, G, Voisin, F, Henrot-Versillé, S, Torchinsky, S, Rambaud, D, Prêle, D, Piat, M, Montier, L, Marty, W, Marnieros, S, Maestre, S, Hoang, D, Chapron, C, Bélier, B, Zmuidzinas, Jonas, Gao, Jian-Rong, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: the QUBIC experiment, Time-Domain Multiplexing, Integrated circuit, SiGe Application-Specific Integrated Circuit, 01 natural sciences, 7. Clean energy, Multiplexing, Multiplexer, law.invention, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, law, Transition-Edge Sensor, 0103 physical sciences, Cosmic Microwave Background, Astronomical interferometer, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, 010303 astronomy & astrophysics, Physics, business.industry, Bolometric Interferometry, Detector, Bolometer, Millimeter, Submillimeter, Far-Infrared, Detectors, Instrumentation, Cosmic Microwave Background, CMB instrumentation, SiGe ApplicationSpecific Integrated Circuit, Superconducting QUantum Interference Device, TimeDomain Multiplexing, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Applied Mathematics, Electrical and Electronic Engineering, Interferometry, Superconducting QUantum Interference Devices, Transition edge sensor, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: International audience; QUBIC (the Q and U Bolometric Interferometer for Cosmology) is a ground-based experiment which seeks to improve the current constraints on the amplitude of primordial gravitational waves. It exploits the unique technique, among Cosmic Microwave Background experiments, of bolometric interferometry, combining together the sensitivity of bolometric detectors with the control of systematic effects typical of interferometers. QUBIC will perform sky observations in polarization, in two frequency bands centered at 150 and 220 GHz, with two kilo-pixel focal plane arrays of NbSi Transition-Edge Sensors (TES) cooled down to 350 mK. A subset of the QUBIC instrument, the so called QUBIC Technological Demonstrator (TD), with a reduced number of detectors with respect to the full instrument, will be deployed and commissioned before the end of 2018. The voltage-biased TES are read out with Time Domain Multiplexing and an unprecedented multiplexing (MUX) factor equal to 128. This MUX factor is reached with two-stage multiplexing: a traditional one exploiting Superconducting QUantum Interference Devices (SQUIDs) at 1K and a novel SiGe Application-Specific Integrated Circuit (ASIC) at 60 K. The former provides a MUX factor of 32, while the latter provides a further 4. Each TES array is composed of 256 detectors and read out with four modules of 32 SQUIDs and two ASICs. A custom software synchronizes and manages the readout and detector operation, while the TES are sampled at 780 Hz (100kHz/128 MUX rate). In this work we present the experimental characterization of the QUBIC TES arrays and their multiplexing readout chain, including time constant, critical temperature, and noise properties.
Published: 2018

21. QUBIC: the Q and U bolometric interferometer for cosmology

Author: Y. Giraud-Héraud, E. Bréelle, P. A. R. Ade, A. Zullo, P. Ringegni, A. Mennella, M. M. Gamboa Lerena, D. Bennett, M. González, Emory F. Bunn, Francesco Cavaliere, R. Puddu, M. De Leo, L. Montier, M. Stolpovskiy, M. Gómez Berisso, M. Giard, C. Perbost, L. Grandsire, Peter T. Timbie, Cristian Franceschet, Matthieu Tristram, Gustavo E. Romero, E. Jules, Simon J. Melhuish, S. Spinelli, A. Baù, G. de Gasperis, J.-Ph. Bernard, G. Bordier, G. Polenta, M. De Petris, P. de Bernardis, A. Lowitz, Nicola Vittorio, E. Guerrard, P. Battaglia, M. Piat, Rocco D'Agostino, O. Perdereau, Lucio Piccirillo, Vladimir V. Luković, Bruce Rafael Mellado Garcia, F. Piacentini, J. Aumont, Massimo Gervasi, D. Prêle, Thibaut Louis, Alessandro Coppolecchia, Sophie Henrot-Versille, S. Loucatos, R. Charlassier, L. M. Mundo, L. Dumoulin, J. Kaplan, P. Chanial, J. D. Murphy, A. Fasciszewski, J. Bonaparte, C. Kristukat, S. Vanneste, Alessandro Paiella, Gabriele Coppi, Silvia Masi, A. Di Donato, Federico Pezzotta, L. Mele, B. Bélier, Steve Torchinsky, D. Viganò, Maria Salatino, D. Auguste, E. Olivieri, A. Mattei, J.-Ch. Hamilton, H. Pastoriza, D. Harari, F. Columbro, G. Amico, M.-A. Bigot-Sazy, A. Passerini, D. Buzi, C. Scóccola, Carole Tucker, G. Barbarán, C. Chapron, N. Bleurvacq, J. Bonis, F. Couchot, Andrei Korotkov, R. Luterstein, A. Tartari, V. Truongcanh, M. Gaspard, F. Voisin, F. Incardona, Damien Rambaud, A. Etchegoyen, B. Watson, Giampaolo Pisano, Marco Bersanelli, Bruno Maffei, Alessandro Schillaci, F. Wicek, Mario Zannoni, A. Pelosi, F. Suarez, A. Gault, Mark McCulloch, S. Marnieros, S. Scully, Créidhe O'Sullivan, Laurent Bergé, S. Banfi, D. Burke, J. A. Murphy, D. T. Hoang, Marcin Gradziel, Alessandro Buzzelli, J.-P. Thermeau, Victor Haynes, X. Garrido, Gregory S. Tucker, Giuseppe D'Alessandro, M. C. Medina, F. Pajot, Elia S. Battistelli, Luca Lamagna, D. Gayer, Andrew May, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Zmuidzinas J.,Gao J.-R., Ade, P, Zullo, A, Zannoni, M, Wicek, F, Watson, B, Voisin, F, Vittorio, N, Viganò, D, Vanneste, S, Tucker, G, Tucker, C, Truongcanh, V, Tristram, M, Torchinsky, S, Timbie, P, Thermeau, J, Tartari, A, Suarez, F, Stolpovskiy, M, Spinelli, S, Scully, S, Scóccola, C, Schillaci, A, Salatino, M, Romero, G, Ringegni, P, Rambaud, D, Puddu, R, Prêle, D, Polenta, G, Pisano, G, Piccirillo, L, Piat, M, Piacentini, F, Pezzotta, F, Perdereau, O, Perbost, C, Pelosi, A, Pastoriza, H, Passerini, A, Pajot, F, Paiella, A, Olivieri, E, Murphy, J, Mundo, L, Montier, L, Mennella, A, Melhuish, S, Mele, L, Medina, M, Mcculloch, M, May, A, Mattei, A, Masi, S, Marnieros, S, Maffei, B, Luterstein, R, Lukovic, V, Lowitz, A, Louis, T, Loucatos, S, Lamagna, L, Bennett, D, Kristukat, C, Korotkov, A, Kaplan, J, Jules, E, Incardona, F, Hoang, D, Harari, D, Hamilton, J, Guerrard, E, Grandsire, L, Gradziel, M, González, M, Gómez Berisso, M, Giraud-Héraud, Y, Giard, M, Gervasi, M, Gayer, D, Gault, A, Gaspard, M, Garrido, X, García, B, Gamboa Lerena, M, Franceschet, C, Fasciszewski, A, Etchegoyen, A, Henrot-Versillé, S, Haynes, V, Dumoulin, L, Di Donato, A, De Petris, M, De Leo, M, de Gasperis, G, de Bernardis, P, D’Alessandro, G, D'Agostino, R, Couchot, F, Coppolecchia, A, Coppi, G, Columbro, F, Charlassier, R, Chapron, C, Chanial, P, Cavaliere, F, Buzzelli, A, Buzi, D, Burke, D, Bunn, E, Bréelle, E, Bordier, G, Bonis, J, Bonaparte, J, Bleurvacq, N, Bigot-Sazy, M, Bersanelli, M, Bernard, J, Bergé, L, Bélier, B, Baù, A, Battistelli, E, Battaglia, P, Barbarán, G, Banfi, S, Aumont, J, Auguste, D, Amico, G, O'Sullivan, C, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Zmuidzinas, Jonas, Gao, Jian-Rong, Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: B-modes, bolometric interferometry, CMB, QUBIC, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Applied Mathematics, Electrical and Electronic Engineering, cosmic microwave background, Cosmic microwave background, Interference (wave propagation), 01 natural sciences, 7. Clean energy, law.invention, 010309 optics, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, law, 0103 physical sciences, Electronic, Optical and Magnetic Materials, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Millimeter, Submillimeter, Far-Infrared, Detectors, Instrumentation, Cosmic Microwave Background, Polarization, Physics, millimetre-wave, Gravitational wave, business.industry, Detector, Bolometer, Polarizer, interferometry, Interferometry, Dichroic filter, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: QUBIC, the Q & U Bolometric Interferometer for Cosmology, is a novel ground-based instrument that has been designed to measure the extremely faint B-mode polarisation anisotropy of the cosmic microwave background at intermediate angular scales (multipoles of 𝑙 = 30 − 200). Primordial B-modes are a key prediction of Inflation as they can only be produced by gravitational waves in the very early universe. To achieve this goal, QUBIC will use bolometric interferometry, a technique that combines the sensitivity of an imager with the systematic error control of an interferometer. It will directly observe the sky through an array of 400 back-to-back entry horns whose signals will be superimposed using a quasi-optical beam combiner. The resulting interference fringes will be imaged at 150 and 220 GHz on two focal planes, each tiled with NbSi Transition Edge Sensors, cooled to 320 mK and read out with time-domain multiplexing. A dichroic filter placed between the optical combiner and the focal planes will select the two frequency bands. A very large receiver cryostat will cool the optical and detector stages to 40 K, 4 K, 1 K and 320 mK using two pulse tube coolers, a novel 4He sorption cooler and a double-stage 3He/4He sorption cooler. Polarisation modulation and selection will be achieved using a cold stepped half-wave plate (HWP) and polariser, respectively, in front of the sky-facing horns. A key feature of QUBIC’s ability to control systematic effects is its ‘self-calibration’ mode where fringe patterns from individual equivalent baselines can be compared. When observing, however, all the horns will be open simultaneously and we will recover a synthetic image of the sky in the I, Q and U Stokes’ parameters. The synthesised beam pattern has a central peak of approximately 0.5 degrees in width, with secondary peaks further out that are damped by the 13-degree primary beam of the horns. This is Module 1 of QUBIC which will be installed in Argentina, near the city of San Antonio de los Cobres, at the Alto Chorrillos site (4869 m a.s.l.), Salta Province. Simulations have shown that this first module could constrain the tensor-to-scalar ratio down to σ(r) = 0.01 after a two-year survey. We aim to add further modules in the future to increase the angular sensitivity and resolution of the instrument. The QUBIC project is proceeding through a sequence of steps. After an initial successful characterisation of the detection chain, a technological demonstrator is being assembled to validate the full instrument design and to test it electrically, thermally and optically. The technical demonstrator is a scaled-down version of Module 1 in terms of the number of detectors, input horns and pulse tubes and a reduction in the diameter of the combiner mirrors and filters, but is otherwise similar. The demonstrator will be upgraded to the full module in 2019. In this paper we give an overview of the QUBIC project and instrument.
Published: 2018

22. Optical modelling and analysis of the Q and U bolometric interferometer for cosmology

Author: Mikhail Stolpovskiy, Emory F. Bunn, Federico Pezzotta, O. Rigaut, M.-A. Bigot-Sazy, A.-A. Drilien, J.D. Murphy, Simon J. Melhuish, Martin Gamboa, Laurence P. Sadwick, Alessandro Schillaci, A. Baù, N. Holtzer, Nathanaël Bleurvac, A. Mennella, F. Voisin, Beatriz García, X. Garrido, E. Guerrard, Giuseppe D' Alessandro, Vladimir V. Luković, R. Luterstein, D. Burke, D. Prêle, D. Bennett, Alberto Etchegoyen, C. Kristukat, Delphine Néel, Paolo de Bernardis, J. Bonaparte, Massimo Gervasi, Alessandro Paiella, L. Montier, M. González, P. Battaglia, Y. Giraud-Héraud, A. Zullo, Giampaolo Pisano, Maria Salatino, D. Auguste, E. Jules, M. Gaspard, Olivier Perdereau, D. Viganò, P. Ringegni, A. Gault, M. Gómez Berisso, F. Piacentini, Jean-Philippe Bernard, J. Kaplan, F. Incardona, Cristian Franceschet, Matthieu Tristram, D. T. Hoang, Lucio Piccirillo, Jonathan Aumont, François Couchot, B. Bélier, F. Suarez, E. Olivieri, P. Chanial, C. Scóccola, S. Banfi, Carole Tucker, Sophie Henrot-Versille, G. Amico, H. Pastoriza, Robert A. Watson, G. de Gasperis, Marcin Gradziel, Nicola Vittorio, D. Harari, D. Buzi, G. Bordier, G. Barbarán, J.-P. Thermeau, Victor Haynes, Créidhe O'Sullivan, Laurent Bergé, T. Louis, J. Bonis, V. Truongcanh, L. Grandsire, Marco De Petris, Peter T. Timbie, Andrei Korotkov, Marco Bersanelli, G. Polenta, Mario Zannoni, Damien Rambaud, Gustavo E. Romero, A. Pelosi, F. Wicek, Mark McCulloch, S. Scully, M. De Leo, L. Dumoulin, Francesco Cavaliere, Alessandro Buzzelli, A. Lowitz, C. Perbost, Alessandro Coppolecchia, François Pajot, A. Fasciszewski, Bruno Maffei, Martin Giard, Elia S. Battistelli, D. Gayer, Tianxin Yang, Gregory S. Tucker, M. C. Medina, A. Passerini, Jean Christophe Hamilton, A. Tartari, L. M. Mundo, Michel Piat, S. Marnieros, Eimante Kalinauskaite, A. Mattei, J. Lande, F. Columbro, R. Puddu, S. Spinelli, Andrew May, Luca Lamagna, E. Bréelle, J. Anthony Murphy, Rocco D'Agostino, S. Loucatos, Gabriele Coppi, Steve Torchinsky, Silvia Masi, A. Di Donato, C. Chapron, R. Charlassier, L. Mele, Sadwick L.P.,Yang T., Burke, D, Gayer, D, Kalinauskaite, E, O'Sullivan, C, Murphy, J, Scully, S, De Petris, M, De Leo, M, Mennella, A, Torchinsky, S, Zannoni, M, Amico, G, Auguste, D, Aumont, J, Banfi, S, Barbaran, G, Battaglia, P, Battistelli, E, Bau, A, Belier, B, Bennett, D, Berge, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bleurvac, N, Bonaparte, J, Bonis, J, Bordier, G, Breelle, E, Bunn, E, Buzi, D, Buzzelli, A, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Columbro, F, Coppi, G, Coppolecchia, A, Couchot, F, D'Alessandro, G, D'Agostino, R, De Bernardis, P, De Gasperis, G, Di Donato, A, Drilien, A, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Franceschet, C, Gamboa-Lerena, M, Garcia, B, Garrido, X, Gaspard, M, Gault, A, Gervasi, M, Giard, M, Giraud-Heraud, Y, Gomez Berisso, M, Gonzalez, M, Gradziel, M, Grandsire, L, Guerrard, E, Hamilton, J, Harari, D, Haynes, V, Henrot-Versille, S, Hoang, D, Holtzer, N, Incardona, F, Jules, E, Kaplan, J, Korotkov, A, Kristukat, C, Lamagna, L, Lande, J, Loucatos, S, Louis, T, Lowitz, A, Lukovic, V, Luterstein, R, Maffei, B, Marnieros, S, Masi, S, Mattei, A, May, A, Mcculloch, M, Medina, M, Mele, L, Melhuish, S, Mundo, L, Montier, L, Neel, D, Olivieri, E, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perdereau, O, Pezzotta, F, Piacentini, F, Piat, M, Piccirillo, L, Pisano, G, Polenta, G, Prele, D, Puddu, R, Rambaud, D, Rigaut, O, Ringegni, P, Romero, G, Salatino, M, Schillaci, A, Scoccola, C, Spinelli, S, Stolpovskiy, M, Suarez, F, Tartari, A, Thermeau, J, Timbie, P, Tristram, M, Truongcanh, V, Tucker, G, Tucker, C, Vigano, D, Vittorio, N, Voisin, F, Watson, B, Wicek, F, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: Cosmic microwave background, Astrophysics::Cosmology and Extragalactic Astrophysics, CMB, 01 natural sciences, 7. Clean energy, Radio spectrum, law.invention, Optics, law, 0103 physical sciences, B-modes, Electronic, Optical Modelling, Black-body radiation, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Optical and Magnetic Materials, Electrical and Electronic Engineering, 010306 general physics, 010303 astronomy & astrophysics, Polarisation, Physics, business.industry, Applied Mathematics, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, bolometric interferometry, Cosmology, Simulation, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Image plane, Redshift, Interferometry, B-mode, Millimeter, business
Abstract: International audience; Remnant radiation from the early universe, known as the Cosmic Microwave Background (CMB), has been redshifted and cooled, and today has a blackbody spectrum peaking at millimetre wavelengths. The QUBIC (Q&U Bolometric Interferometer for Cosmology) instrument is designed to map the very faint polaristion structure in the CMB. QUBIC is based on the novel concept of bolometric interferometry in conjunction with synthetic imaging. It will have a large array of input feedhorns, which creates a large number of interferometric baselines. The beam from each feedhorn is passed through an optical combiner, with an off-axis compensated Gregorian design, to allow the generation of the synthetic image. The optical-combiner will operate in two frequency bands (150 and 220 GHz with 25% and 18.2 % bandwidth respectively) while cryogenically cooled TES bolometers provide the sensitivity required at the image plane. The QUBIC Technical Demonstrator (TD), a proof of technology instrument that contains 64 input feed-horns, is currently being built and will be installed in the Alto Chorrillos region of Argentina. The plan is then for the full QUBIC instrument (400 feed-horns) to be deployed in Argentina and obtain cosmologically significant results. In this paper we will examine the output of the manufactered feed-horns in comparison to the nominal design. We will show the results of optical modelling that has been performed in anticipation of alignment and calibration of the TD in Paris, in particular testing the validity of real laboratory environments. We show the output of large calibrator sources (50 ° full width haf max Gaussian beams) and the importance of accurate mirror definitions when modelling large beams. Finally we describe the tolerance on errors of the position and orientation of mirrors in the optical combiner.
Published: 2018

23. Thermal architecture for the QUBIC cryogenic receiver

Author: R. Charlassier, G. de Gasperis, J. Kaplan, M. Piat, X. Garrido, J. Bonaparte, M.-A. Bigot-Sazy, B. Bélier, P. Battaglia, F. Piacentini, Alessandro Buzzelli, D. Burke, N. Bleurvacq, Andrei Korotkov, R. Puddu, F. Voisin, C. Perbost, E. Guerrard, J. A. Murphy, S. Loucatos, S. Spinelli, S. Vanneste, Damien Rambaud, Peter A. R. Ade, Gustavo E. Romero, P. Chanial, Peter T. Timbie, G. Polenta, A. Lowitz, Vladimir V. Luković, Andrew May, J.-Ch. Hamilton, B. Watson, Bruno Maffei, F. Wicek, Bruce Rafael Mellado Garcia, P. de Bernardis, F. Couchot, A. Gault, E. Olivieri, H. Pastoriza, D. Harari, L. Dumoulin, J.-Ph. Bernard, M. Stolpovskiy, Alessandro Coppolecchia, Mark McCulloch, S. Marnieros, A. Mennella, F. Incardona, G. Barbarán, Francesco Cavaliere, M. M. Gamboa Lerena, D. Viganò, F. Suarez, S. Banfi, E. Bréelle, A. Fasciszewski, G. Bordier, L. M. Mundo, D. Bennett, Y. Giraud-Héraud, Federico Pezzotta, A. Passerini, M. González, J. Bonis, J. Aumont, J.-P. Thermeau, Alessandro Schillaci, A. Tartari, A. Mattei, M. Gómez Berisso, E. Jules, L. Mele, M. Giard, L. Grandsire, Gabriele Coppi, Steve Torchinsky, F. Columbro, O. Perdereau, P. Ringegni, Simon J. Melhuish, Massimo Gervasi, A. Baù, Nicola Vittorio, Rocco D'Agostino, M. De Leo, Lucio Piccirillo, Thibaut Louis, D. Prêle, Sophie Henrot-Versille, Maria Salatino, D. Auguste, M. De Petris, R. Luterstein, C. Scóccola, Carole Tucker, Silvia Masi, A. Di Donato, Giampaolo Pisano, G. Amico, Cristian Franceschet, Matthieu Tristram, D. Buzi, Emory F. Bunn, Créidhe O'Sullivan, Laurent Bergé, V. Truongcanh, M. Gaspard, A. Etchegoyen, Marco Bersanelli, Mario Zannoni, A. Pelosi, S. Scully, J. D. Murphy, Alessandro Paiella, C. Kristukat, A. Zullo, Gregory S. Tucker, F. Pajot, Elia S. Battistelli, D. Gayer, Giuseppe D'Alessandro, M. C. Medina, C. Chapron, D. T. Hoang, Marcin Gradziel, Luca Lamagna, Victor Haynes, L. Montier, Zmuidzinas, Jonas, Gao, Jian-Rong, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Zmuidzinas, J, Gao, JR, Tristram, M, Passerini, A, Franceschet, C, Scully, S, Ade, P, Zullo, A, Zannoni, M, Wicek, F, Watson, B, Voisin, F, Vittorio, N, Viganò, D, Vanneste, S, Tucker, G, Tucker, C, Truongcanh, V, Torchinsky, S, Timbie, P, Tartari, A, Suarez, F, Stolpovskiy, M, Spinelli, S, Scóccola, C, Salatino, M, Romero, G, Ringegni, P, Rambaud, D, Puddu, R, Prêle, D, Polenta, G, Pisano, G, Piacentini, F, Pezzotta, F, Perdereau, O, Perbost, C, Pelosi, A, Pastoriza, H, Pajot, F, Paiella, A, Olivieri, E, O'Sullivan, C, Murphy, J, Mundo, L, Montier, L, Mennella, A, Mele, L, Medina, M, Mcculloch, M, Mattei, A, Marnieros, S, Maffei, B, Luterstein, R, Lukovic, V, Lowitz, A, Louis, T, Loucatos, S, Lamagna, L, Kristukat, C, Korotkov, A, Kaplan, J, Jules, E, Incardona, F, Hoang, D, Henrot-Versillé, S, Haynes, V, Harari, D, Hamilton, J, Guerrard, E, Grandsire, L, Gradziel, M, González, M, Gómez Berisso, M, Giraud-Héraud, Y, Giard, M, Gervasi, M, Gayer, D, Gault, A, Gaspard, M, Garrido, X, García, B, Gamboa Lerena, M, Fasciszewski, A, Etchegoyen, A, Dumoulin, L, Di Donato, A, De Petris, M, De Leo, M, de Gasperis, G, D'Agostino, R, Couchot, F, Coppolecchia, A, Bennett, D, Burke, D, Columbro, F, Charlassier, R, Chanial, P, Cavaliere, F, Buzzelli, A, Buzi, D, Bunn, E, Bréelle, E, Bordier, G, Bonis, J, Bonaparte, J, Bleurvacq, N, Bigot-Sazy, M, Bersanelli, M, Bernard, J, Bergé, L, Bélier, B, Baù, A, Battistelli, E, Battaglia, P, Barbarán, G, Banfi, S, Aumont, J, Auguste, D, Amico, G, Thermeau, J, Schillaci, A, Piccirillo, L, Piat, M, Melhuish, S, Masi, S, de Bernardis, P, D'Alessandro, G, Coppi, G, Chapron, C, May, A, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
Subjects: Cryostat, Physics - Instrumentation and Detectors, Cryogenics, Bolometric interferometry, QUBIC, interferometer, Cosmic microwave background, bolometric interferometry, cryogenics, experimental cosmology, heat switch, sorption cooler, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Applied Mathematics, Electrical and Electronic Engineering, FOS: Physical sciences, cosmic background radiation: polarization, 7. Clean energy, 01 natural sciences, law.invention, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, bolometer, law, 0103 physical sciences, Thermal, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Sorption cooler, 010306 general physics, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Heat switch, business.industry, Bolometer, Detector, Instrumentation and Detectors (physics.ins-det), Polarization (waves), Experimental cosmology, Interferometry, cryogenics: design, B-mode, Millimeter, Submillimeter, Far-Infrared, Detectors, Instrumentation, Cryogenics, Cosmic Microwave Background, business, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: International audience; QUBIC, the QU Bolometric Interferometer for Cosmology, is a novel forthcoming instrument to measure the B-mode polarization anisotropy of the Cosmic Microwave Background. The detection of the B-mode signal will be extremely challenging; QUBIC has been designed to address this with a novel approach, namely bolometric interferometry. The receiver cryostat is exceptionally large and cools complex optical and detector stages to 40 K, 4 K, 1 K and 350 mK using two pulse tube coolers, a novel 4He sorption cooler and a double-stage 3He/4He sorption cooler. We discuss the thermal and mechanical design of the cryostat, modelling and thermal analysis, and laboratory cryogenic testing.
Published: 2018

24. QUBIC - the Q&U Bolometric Interferometer for Cosmology: A novel way to look at the polarized Cosmic Microwave Background

Author: M. Piat, A. Passerini, M. W. Ng, J. Rodriguez Martino, A. Ghribi, Alessandro Buzzelli, M. Giard, N. Bleurvacq, F. Piacentini, S. Melhuish, L. Mele, P. Chanial, J.-Ch. Hamilton, Maria Salatino, R. Puddu, L. Grandsire, J. Lande, Peter T. Timbie, Jonathan Aumont, Carole Tucker, B. Watson, Bruno Maffei, Andrei Korotkov, Damien Rambaud, A. Zullo, O. Rigaut, C. Perbost, Massimo Gervasi, Mark McCulloch, S. Marnieros, A. Baù, A. Lowitz, Giampaolo Pisano, D. Néel, G. Bordier, M. De Petris, P. Battaglia, N. Krachmalnicoff, L. Montier, A. Mennella, D. Cammilleri, O. Perdereau, Michele De Leo, Créidhe O'Sullivan, Cristian Franceschet, F. Incardona, D. Bennett, Peter A. R. Ade, D. Buzi, Victor Haynes, F. Couchot, F. Suarez, G. S. Tucker, N. Vittori, M. Tristram, D. Harari, Lucio Piccirillo, B. Bélier, Jean Kaplan, Sophie Henrot-Versille, S. Loucatos, Luca Lamagna, L. Dumoulin, Alessandro Paiella, Bruce Rafael Mellado Garcia, Alessandro Coppolecchia, F. Columbro, A. Tartari, D. Viganò, J. Brossard, Rocco D'Agostino, Andrew May, F. Pajot, Elia S. Battistelli, D. Gayer, L. Bergé, Silvia Masi, D. Burke, Marcin Gradziel, N. Holtzer, Gabriele Coppi, Steve Torchinsky, Giuseppe D'Alessandro, M. C. Medina, C. Chapron, A. Etchegoyen, Marco Bersanelli, Mario Zannoni, A. Pelosi, S. Scully, G. de Gasperis, Bigot-Sazy, J.-Ph. Bernard, A. Gault, S. Banfi, Vladimir V. Luković, Francesco Cavaliere, E. Bunn, D. Prêle, A. Murphy, F. Voisin, M. Stolpovskiy, Gustavo E. Romero, F. Del Torto, Y. Giraud-Héraud, P. de Bernardis, A. Schillaci, T. Decourcelle, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Mennella, A, Ade, P, Aumont, J, Banfi, S, Incardona, F, Battaglia, P, Battistelli, E, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bleurvacq, N, Bordier, G, Brossard, J, Bunn, E, Burke, D, Buzi, D, Buzzelli, A, Cammilleri, D, Cavaliere, F, Chanial, P, Chapron, C, Columbro, F, Coppi, G, Coppolecchia, A, Couchot, F, D'Agostino, R, D'Alessandro, G, De Bernardis, P, De Gasperis, G, De Leo, M, De Petris, M, Decourcelle, T, Del Torto, F, Dumoulin, L, Etchegoyen, A, Franceschet, C, Garcia, B, Gault, A, Gayer, D, Gervasi, M, Ghribi, A, Giard, M, Giraud-Héraud, Y, Gradziel, M, Grandsire, L, Hamilton, J, Harari, D, Haynes, V, Henrot-Versillé, S, Holtzer, N, Kaplan, J, Korotkov, A, Krachmalnicoff, N, Lamagna, L, Lande, J, Loucatos, S, Lowitz, A, Lukovic, V, Maffei, B, Marnieros, S, Martino, J, Masi, S, May, A, Mcculloch, M, Medina, M, Mele, L, Melhuish, S, Montier, L, Murphy, A, Néel, D, Ng, M, O'Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pelosi, A, Perbost, C, Perdereau, O, Piacentini, F, Piat, M, Piccirillo, L, Pisano, G, Prêle, D, Puddu, R, Rambaud, D, Rigaut, O, Romero, G, Salatino, M, Schillaci, A, Scully, S, Stolpovskiy, M, Suarez, F, Tartari, A, Timbie, P, Torchinsky, S, Tristram, M, Tucker, C, Tucker, G, Viganò, D, Vittori, N, Voisin, F, Watson, B, Zannoni, M, and Zullo, A
Subjects: cosmological model, interferometer, Cosmic microwave background, Cosmic background radiation, FOS: Physical sciences, 02 engineering and technology, cosmic background radiation, 01 natural sciences, 7. Clean energy, Cosmology, law.invention, 010309 optics, FIS/05 - ASTRONOMIA E ASTROFISICA, bolometer, law, 0103 physical sciences, Astronomical interferometer, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics, Physics, polarization, Gravitational wave, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, gravitational radiation: primordial, Cosmic Microwave Background, Polarimetry, Interferometry, Bolometers, Astronomy, 021001 nanoscience & nanotechnology, Polarization (waves), sensitivity, calibration, Interferometry, duality, 0210 nano-technology, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: In this paper we describe QUBIC, an experiment that takes up the challenge posed by the detection of primordial gravitational waves with a novel approach, that combines the sensitivity of state-of-the art bolometric detectors with the systematic effects control typical of interferometers. The so-called "self-calibration" is a technique deeply rooted in the interferometric nature of the instrument and allows us to clean the measured data from instrumental effects. The first module of QUBIC is a dual band instrument (150 GHz and 220 GHz) that will be deployed in Argentina during the Fall 2018., Presented at the EPS Conference on High Energy Physics, Venice (Italy), 5-12 July 2017 Accepted for publication in conference proceedings
Published: 2017

25. Efficacy of etravirine combined with darunavir or other ritonavir-boosted protease inhibitors in HIV-1-infected patients: An observational study using pooled European cohort data

Author: J, Vingerhoets, V, Calvez, P, Flandre, A-G, Marcelin, F, Ceccherini-Silberstein, C-F, Perno, M, Mercedes Santoro, R, Bateson, M, Nelson, A, Cozzi-Lepri, J, Grarup, J, Lundgren, F, Incardona, R, Kaiser, A, Sonnerborg, B, Clotet, R, Paredes, H F, Günthard, B, Ledergerber, A, Hoogstoel, S, Nijs, L, Tambuyzer, L, Lavreys, and M, Opsomer
Subjects: Male, efficacy, HIV Infections, protease inhibitor, Meta-Analysis as Topic, Nitriles, Odds Ratio, Humans, darunavir/ritonavir, etravirine, Darunavir, Sulfonamides, Ritonavir, HIV-1, HIV Protease Inhibitors, Middle Aged, Viral Load, Settore MED/07 - Microbiologia e Microbiologia Clinica, United Kingdom, CD4 Lymphocyte Count, Pyridazines, Pyrimidines, Italy, Spain, Drug Therapy, Combination, Female, France, Switzerland
Abstract: This observational study in antiretroviral treatment-experienced, HIV-1-infected adults explored the efficacy of etravirine plus darunavir/ritonavir (DRV group; n = 999) vs. etravirine plus an alternative boosted protease inhibitor (other PI group; n = 116) using pooled European cohort data.Two international (EuroSIDA; EUResist Network) and five national (France, Italy, Spain, Switzerland and UK) cohorts provided data (collected in 2007-2012). Stratum-adjusted (for confounding factors) Mantel-Haenszel differences in virological responses (viral load50 HIV-1 RNA copies/mL) and odds ratios (ORs) with 95% confidence intervals (CIs) were derived.Baseline characteristics were balanced between groups except for previous use of antiretrovirals (≥ 10: 63% in the DRV group vs. 49% in the other PI group), including previous use of at least three PIs (64% vs. 53%, respectively) and mean number of PI resistance mutations (2.3 vs. 1.9, respectively). Week 24 responses were 73% vs. 75% (observed) and 49% vs. 43% (missing = failure), respectively. Week 48 responses were 75% vs. 73% and 32% vs. 30%, respectively. All 95% CIs around unadjusted and adjusted differences encompassed 0 (difference in responses) or 1 (ORs). While ORs by cohort indicated heterogeneity in response, for pooled data the difference between unadjusted and adjusted for cohort ORs was small.These data do not indicate a difference in response between the DRV and other PI groups, although caution should be applied given the small size of the other PI group and the lack of randomization. This suggests that the efficacy and virology results from DUET can be extrapolated to a regimen of etravirine with a boosted PI other than darunavir/ritonavir.
Published: 2015

26. EuResist: exploration of multiple modeling techniques for prediction of response to treatment

Author: Maurizio Zazzi, Ehud Aharoni, Andre Altmann, F. Baszó, Penny Bidgood, Gabór Borgulya, J. Denholm Prince, M. Fielder, C. Kent, T. Lengauer, T. Nepusz, H. Neuvirth, Y. Peres, A. Petroczi, M. Prosperi, L. Romano, M. Rosen Zvi, E. Schülter, T. Sing, A. Sönnerborg, R. Thompson, L. Zalány, F. Incardona, Ulivi G., ULIVI, Giovanni, Maurizio, Zazzi, Ehud, Aharoni, Andre, Altmann, F., Baszó, Penny, Bidgood, Gabór, Borgulya, J., Denholm Prince, M., Fielder, C., Kent, T., Lengauer, T., Nepusz, H., Neuvirth, Y., Pere, A., Petroczi, M., Prosperi, L., Romano, M., Rosen Zvi, E., Schülter, T., Sing, A., Sönnerborg, R., Thompson, Ulivi, Giovanni, L., Zalány, F., Incardona, and Ulivi, G.
Published: 2007

27. Endothelin-1 Induces Production of the Neutrophil Chemotactic Factor Interleukin-8 by Human Brain-Derived Endothelial Cells

Author: F.M. Hofman, P. Chen, R. Jeyaseelan, F. Incardona, M. Fisher, and R. Zidovetzki
Subjects: Immunology, Cell Biology, Hematology, Biochemistry
Abstract: Increased levels of endothelin-1 (Et-1), a potent vasoconstrictor, have been correlated with hypertension and neuronal damage in ischemic/reperfusion injury. The presence of polymorphonuclear cells (PMNs) in the brain has been shown to be directly responsible for this observed pathology. To address the question of whether Et-1 plays a role in this process, human brain-derived endothelial cells (CNS-ECs) were cultured with Et-1. The results demonstrate that Et-1 induces production of the neutrophil chemoattractant interleukin-8 (IL-8) twofold to threefold after 72 hours; mRNA was maximal after 1 hour of stimulation. Conditioned culture medium derived from Et-1–stimulated CNS-ECs induced a chemotactic response in the PMN migration assay. The inflammatory cytokines tumor necrosis factor- (TNF) and IL-1β functioned additively with Et-1 in increasing IL-8 production. In contrast, transforming growth factor-β (TGF-β), but not IL-10, completely abolished the effect of Et-1 on IL-8 production. However, Et-1 did not modulate intercellular adhesion molecule-1 (ICAM-1) expression. These data demonstrate that Et-1 may be a risk factor in ischemic/reperfusion injury by inducing increased levels of the neutrophil chemoattractant IL-8. © 1998 by The American Society of Hematology.
Published: 1998

28. How much are homologous peptides homologous?

Author: F. Incardona, Silvia Morante, Giancarlo Rossi, and Valerio Parisi
Subjects: Statistics and Probability, Statistics as Topic, Identity matrix, Peptide, Computational biology, Biology, General Biochemistry, Genetics and Molecular Biology, Homology (biology), Bacterial protein, Homologous chromosome, Humans, sort, Statistical analysis, chemistry.chemical_classification, Genetics, Mutation matrix, Bacteria, Models, Genetic, Sequence Homology, Amino Acid, General Immunology and Microbiology, Applied Mathematics, General Medicine, chemistry, Modeling and Simulation, Viruses, Peptides, General Agricultural and Biological Sciences, Algorithms
Abstract: A statistical analysis designed to deal with the problem of identifying homologous pairs of "short sequences of amino-acids" (= peptides) belonging to different proteins is presented. The conceptual novelty of the searching strategy proposed here lies in the fact that both the degree of homology of the two peptides of the pair (measured by a suitably defined affinity score) and the level of statistical significance of its occurrence are taken into account on equal footing. They are combined in a sort of "biological indicator", characterising each pair. Pairs for which the value of the biological indicator is larger than an appropriate threshold are taken as statistically significant and (putatively) biologically relevant. The method is employed in various test cases and proves to be reliable and efficient. In particular we have studied the cases in which the known existence of an auto-immune response has lead to the identification of homologous peptide pairs between human and viral or bacterial proteins. The detection efficiency of the algorithm in these cases turns out to be especially good when the most naïve affinity table, the Identity matrix, is employed to measure the similarity of amino acidic pairs. In contrast, when the 250-PAM mutation matrix is used, the detection efficiency goes to zero.
Published: 1995

29. Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species

Author: C. Legrand, Jean-Pierre Cazenave, Catherine Ravanat, Ludovic Drouet, J P Maffrand, F. Incardona, M. Freund, B. Boneu, Jean-Marc Herbert, Y. Cadroy, F. Dol, and Jacqueline Roussi
Subjects: Swine, Antithrombin III, Guinea Pigs, Zoology, Platelet Membrane Glycoproteins, Biology, medicine.disease_cause, Cross-reactivity, Thromboplastin, Mice, Dogs, Animal model, Species Specificity, biology.animal, medicine, Animals, Humans, Fibrinopeptide, Prothrombin fragment, Rats, Wistar, Animal species, Blood Coagulation, Fibrinolysis, Thrombosis, Hematology, General Medicine, Platelet Activation, Peptide Fragments, Rats, Biochemistry, Female, Prothrombin, Rabbits, Chickens, Biomarkers, Papio, Peptide Hydrolases, circulatory and respiratory physiology, Baboon
Abstract: The aim of the present study was to investigate the reactivity of immunoreagents developed for clinical applications in humans in different animal species (hen, mouse, rat, rabbit, guinea-pig, dog, pig, sheep, baboon). Prothrombin fragment 1 + 2, thrombin-antithrombin III complex and fibrinopeptide A were tested for coagulation, platelet factor 4 and beta-thromboglobulin for platelet activation, glycoprotein IIb-IIIa, glycoprotein Ib and P-selectin for platelet membrane glycoproteins, D-dimers for fibrinolysis, thrombomodulin for activation of endothelial cells and thrombospondin and von Willebrand factor for adhesive proteins. Prothrombin fragment 1 + 2, platelet factor 4, beta-thromboglobulin and D-dimers were revealed only in baboons. Fibrinopeptide A was well detected in baboons but weakly in mice, dogs, pigs and sheep. Whereas glycoprotein IIb-IIIa was revealed on guinea-pig, dog and sheep platelets and glycoprotein Ib on rabbit and dog platelets, P-selectin and thrombomodulin were never detected. Thrombospondin was revealed in hens, mice, rats, guinea-pigs, pigs, sheep and baboons and von Willebrand factor in mice, rats, guinea-pigs, dogs, pigs, sheep and baboons. Interestingly, thrombin-antithrombin III complex (TAT) was detected in all species tested except the hen. A time- and dose-dependent increase in TAT was observed when rats, dogs or pigs were infused with thromboplastin (4.5-450 microliters/kg/h), while administration of hirudin (1 mg/kg) abolished this TAT generation. Thus, the TAT immunoassay could provide a tool for the screening of antithrombotic drugs in a number of animal species. However, the possibility of using a wider panel of human immunoreagents would appear to be restricted to baboons which display good species cross-reactivity.
Published: 1995

30. HPLC Separations of Normal and Modified Nucleobases and Nucleosides on an Amino Silica Gel Column

Author: Thierry Douki, M.-F. Incardona, Jean Cadet, and Jean-Luc Ravanat
Subjects: chemistry.chemical_compound, Chromatography, Pyrimidine, chemistry, Silica gel, Nucleic acid, Molecular Medicine, Organic chemistry, Chemical modification, Pyrimidone, High-performance liquid chromatography, Nucleobase, Cyclobutane
Abstract: An amino substituted silica gel column was used for the normal phase HPLC separation of nucleic acid components, including free bases and the corresponding 2′-deoxyribo- and ribonucleosides. The chromatographic system was also found to be particularly convenient for the separation of various modified nucleosides, including oxidation products of 2′-deoxyguanosine and pyrimidine components, thymidine cyclobutane dimers, dinucleoside monophosphate photoproducts and pyrimidine (6-4) pyrimidone adducts.
Published: 1993

31. Three‐dimensional localization system for small magnetic dipoles

Author: S. N. Ernè, I. Modena, L. Narici, and F. Incardona
Subjects: Physics, Superconductivity, Computer simulation, Magnetometer, business.industry, Settore FIS/01 - Fisica Sperimentale, Physics::Medical Physics, Detector, Measure (physics), Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), law.invention, Magnetic field, Optics, Nuclear magnetic resonance, law, Position (vector), business, Instrumentation, Magnetic dipole
Abstract: We developed a system for localizing orthogonal triplets of small magnetic dipoles with an array of magnetometers. These triplets can be used to measure, in quasi‐real time, the position of an object. This system is particularly useful when used with superconducting biomagnetic multichannel detectors. We present here a complete numerical simulation of the system performances and the first experimental tests with a biomagnetic detector (an array of 37 superconducting magnetometers). This system can be operated at frequencies outside the range of interest for biomagnetic measurements (that is typically 10−2–103 Hz). It features an accuracy of ±0.3 cm driving the triplet at a field intensity ≊10−12 T. The speed of the algorithm allows for quasi‐real‐time operation (t ∼ 10−1 s).
Published: 1992

32. Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration

Author: J S, Yu, C J, Wheeler, P M, Zeltzer, H, Ying, D N, Finger, P K, Lee, W H, Yong, F, Incardona, R C, Thompson, M S, Riedinger, W, Zhang, R M, Prins, and K L, Black
Subjects: Adult, Cytotoxicity, Immunologic, Male, Brain Neoplasms, Immunotherapy, Active, Dendritic Cells, T-Lymphocytes, Helper-Inducer, Astrocytoma, Middle Aged, Cancer Vaccines, Immunotherapy, Adoptive, Lymphocytes, Tumor-Infiltrating, Antigens, Neoplasm, Humans, Female, Glioblastoma, Immunologic Memory, Aged, T-Lymphocytes, Cytotoxic
Abstract: In this Phase I trial, patients' peripheral blood dendritic cells were pulsed with peptides eluted from the surface of autologous glioma cells. Three biweekly intradermal vaccinations of peptide-pulsed dendritic cells were administered to seven patients with glioblastoma multiforme and two patients with anaplastic astrocytoma. Dendritic cell vaccination elicited systemic cytotoxicity in four of seven tested patients. Robust intratumoral cytotoxic and memory T-cell infiltration was detected in two of four patients who underwent reoperation after vaccination. This Phase I study demonstrated the feasibility, safety, and bioactivity of an autologous peptide-pulsed dendritic cell vaccine for patients with malignant glioma.
Published: 2001

33. DNA Modifications Due to Oxidative Damage

Author: M. Polverelli, Jean-Luc Ravanat, M. F. Incardona, S. Raoul, Jean Cadet, M. Berger, D. Molko, I. Girault, and Bénédicte Morin
Subjects: Purine, chemistry.chemical_compound, chemistry, Biochemistry, Pyrimidine, Guanine, Mutagenesis, DNA, Cytosine, Thymine, Nucleobase
Abstract: Modified purine and pyrimidine bases which constitute one of the major classes of oxidative DNA damage are likely to be involved in mutagenesis and carcinogenesis and possibly in aging. In the present survey, the currently available information on the structural aspects of oxidized DNA bases and their mechanism of formation are critically reviewed. A survey of the main approaches (HPLC separations associated with various spectroscopic detections, gas chromatography-mass spectrometry, postlabeling techniques, immunoassays…) involving either initial acid hydrolysis or enzymatic digestion of DNA which were recently developed for monitoring the formation of oxidative DNA base damage in cells, tissues and biological fluids is also presented. The measurement of the above compounds in biological fluids such as urine may be used for assessing oxidative damage to DNA [5]. Other important sources of oxidation processes are provided by physical agents (ionizing radiation, near-ultraviolet/visible light [6,7]). In the latter case, oxidation of DNA would require the presence of endogenous or exogenous photosensitizers including flavins and porphyrins. In this short survey emphasis has been placed on the oxidation reactions of the guanine moiety of DNA and model compounds as the result of one-electron processes and exposure to oxidizing agents including hydroxyl radicals and singlet oxygen. However, it should be mentioned that relevant information on oxidation reactions of adenine, cytosine and thymine, the other DNA bases is available [see for example, 6–10].
Published: 1997

34. Thrombospondin modulates human breast adenocarcinoma cell adhesion to human vascular endothelial cells

Author: F, Incardona, J M, Lewalle, V, Morandi, S, Lambert, Y, Legrand, J M, Foidart, and C, Legrand
Subjects: Membrane Glycoproteins, Cell Adhesion, Humans, Breast Neoplasms, Endothelium, Vascular, Adenocarcinoma, Thrombospondins, Cell Adhesion Molecules, Cells, Cultured
Abstract: Thrombospondin (TSP), a M(r) 450,000 cytoadhesive glycoprotein, has been shown to potentiate tumor cell metastasis in mice by a mechanism that involves the hemostatic system of the host. In this study, the potential involvement of TSP in the interaction of human mammary adenocarcinoma MCF-7 cells with human umbilical vein endothelial cells (HUVECs) in culture was investigated. Using an ELISA, preconfluent HUVECs synthesized 100-fold more TSP than did MCF-7 cells during 24 h of culture (20 versus 0.2 microgram/10(6) cells). Confocal microscopy localized TSP within intercellular junctions between aggregated MCF-7 cells in suspension. On adherent cells, TSP exhibited a patchy distribution both on the cell surface and in the cytosol. In HUVECs, TSP strongly stained the perinuclear space and was also found in association with cytoskeletal microfibrils. Flow cytometric analysis indicated the presence of a large number of unoccupied receptors for TSP on MCF-7 cells. Binding studies using [125I]TSP demonstrated the presence of 1.6 x 10(6) sites/cell with an apparent Kd of 28 nM. Attachment of radiolabeled MCF-7 cells to a TSP-coated substrate and to HUVEC monolayers was inhibited in the presence of a polyclonal antibody to TSP (10 micrograms/ml) or increasing concentrations (1-10 micrograms/ml) of soluble TSP. Neither nonimmune IgG nor the cell adhesion peptide Gly-Arg-Gly-Asp-Ser (100 micrograms/ml) inhibited these interactions. Inhibition was also observed with heparin (10 micrograms/ml), suggesting the participation of TSP heparin-binding domain(s) and heparin-like molecules. In the presence of an excess of soluble TSP or anti-TSP antibody, MCF-7 cells did not form aggregates in suspension and preformed aggregates were readily dissociated by the addition of soluble TSP. These results indicate that mammary adenocarcinoma cells use TSP to form aggregates and to attach to human endothelial cells. These interactions may have physiological implications during the hematogenous spread of tumor cells.
Published: 1995

35. Measurement of oxidized nucleobases and nucleosides in human urine by using a GC/MS assay in the selective ion monitoring mode

Author: A. E. Favier, M.-F. Incardona, Jean Cadet, and F. Bianchini
Subjects: Detection limit, Chromatography, Chemistry, medicine, Base excision repair, Urine, Gas chromatography–mass spectrometry, medicine.disease_cause, High-performance liquid chromatography, Oxidative stress, Nucleobase, Adduct
Abstract: Urinary excretion of oxidized bases and nucleosides has been suggested as a non-invasive biomarker of oxidative damage and repair. Oxidative adducts, resulting from a variety of reactive oxygen species. are in fact excreted in urine following repair. A method for the analysis of 5-hydroxyuracil (5-OHUra), 5-hydroxy-2’-deoxyuridine (5-OHdUrd). 5-hy- droxymethyluracil (5-HMUra). 5-hydroxymethyl-2’-deoayuridine (5-HMdUrd) in urine has been developed, based on GC/MS quantification. Stable isotopically labelled (M + 4) analogues, synthesized in our laboratory, are used as internal standards, assuring appropriate quantification in complex biological fluids. Urines are first purified by HPLC on a reverse phase column and fractions corresponding to the compounds of interest derivatized for GC/MS analysis. Two different derivatives for GC/MS determination, the trimethylsylyl (TMS) and the tert-butyldimethylsylyl (t-RDMS) derivatives. have been tested. Detection limit in the selective ion monitoring (SIM) mode is generally two-fold lomer with t-BDMS. Preliminary results on four healthy subjects show that the oxidized bases 5-OHUra and 5-HMUra are excreted in urine (approximately 0.7 nmol/kg/day), while the corresponding nucleosides are not detectable. The developed method could have important applications in the analysis of oxidative lesions in DNA exposed to oxidative stress or in DNA from biological samples.
Published: 1995

36. Measurement of oxidative base damage to DNA by using HPLC-32P-postlabelling and GC/MS-selective ion monitoring assays

Author: J, Cadet, M F, Incardona, F, Odin, D, Molko, J F, Mouret, M, Polverelli, H, Faure, V, Ducros, M, Tripier, and A, Favier
Subjects: Evaluation Studies as Topic, DNA, Reference Standards, Oxidation-Reduction, Phosphorus Radioisotopes, Sensitivity and Specificity, Chromatography, High Pressure Liquid, Gas Chromatography-Mass Spectrometry, DNA Damage, Environmental Monitoring
Abstract: A 32P-postlabelling assay has been developed for singling out specific oxidized base lesions. Emphasis was placed on the quantitative aspect and the accuracy of the assay, which require the use of calibration curves and microreactions, respectively. The method was successfully applied to the detection and the measurement of adenine N1-oxide and 5-hydroxymethyluracil in cells exposed to agents inducing oxidative stress including H2O2 and UV-A radiation. The sensitivity of the assay allows the detection of one lesion in 10(6) normal bases in 1 microgram of DNA. The GC/MS method when coupled to the selective ion monitoring (SIM) technique is about twenty times less sensitive, even for suitable substrates such as 5-hydroxymethyluracil and 5-hydroxyuracil, than the 32P-postlabelling assay. However, the former assay is much easier to apply, even though a derivatization step is necessary, and provides unambiguous structural information on the compound to be measured. Accurate quantitative measurements can be obtained when stable, isotopically labelled standards are available.
Published: 1993

37. Incorporating temporal dynamics of mutations to enhance the prediction capability of antiretroviral therapy's outcome for HIV-1.

Author: Di Teodoro G, Pirkl M, Incardona F, Vicenti I, Sönnerborg A, Kaiser R, Palagi L, Zazzi M, and Lengauer T
Subjects: Humans, Drug Resistance, Viral genetics, Viral Load, Anti-HIV Agents therapeutic use, Anti-HIV Agents pharmacology, Treatment Outcome, HIV-1 genetics, HIV Infections drug therapy, HIV Infections virology, Mutation
Abstract: Motivation: In predicting HIV therapy outcomes, a critical clinical question is whether using historical information can enhance predictive capabilities compared with current or latest available data analysis. This study analyses whether historical knowledge, which includes viral mutations detected in all genotypic tests before therapy, their temporal occurrence, and concomitant viral load measurements, can bring improvements. We introduce a method to weigh mutations, considering the previously enumerated factors and the reference mutation-drug Stanford resistance tables. We compare a model encompassing history (H) with one not using this information (NH)., Results: The H-model demonstrates superior discriminative ability, with a higher ROC-AUC score (76.34%) than the NH-model (74.98%). Wilcoxon test results confirm significant improvement of predictive accuracy for treatment outcomes through incorporating historical information. The increased performance of the H-model might be attributed to its consideration of latent HIV reservoirs, probably obtained when leveraging historical information. The findings emphasize the importance of temporal dynamics in acquiring mutations. However, our result also shows that prediction accuracy remains relatively high even when no historical information is available., Availability and Implementation: This analysis was conducted using the Euresist Integrated DataBase (EIDB). For further validation, we encourage reproducing this study with the latest release of the EIDB, which can be accessed upon request through the Euresist Network., (© The Author(s) 2024. Published by Oxford University Press.)
Published: 2024
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38. In-hospital mortality during the wild-type, alpha, delta, and omicron SARS-CoV-2 waves: a multinational cohort study in the EuCARE project.

Author: Hedberg P, Parczewski M, Serwin K, Marchetti G, Bai F, Ole Jensen BE, Pereira JPV, Drobniewski F, Reschreiter H, Naumovas D, Ceccherini-Silberstein F, Rubio Quintanares GH, Mwau M, Toscano C, König F, Pfeifer N, Zazzi M, Fanti I, Incardona F, Cozzi-Lepri A, Sönnerborg A, and Nauclér P
Abstract: Background: Investigating outcomes of hospitalised COVID-19 patients throughout the pandemic is crucial to understand the impact of different SARS-CoV-2 variants. We compared 28-day in-hospital mortality of Wild-type, Alpha, Delta, and Omicron variant infections. Whether the difference in risk by variant varied by age was also evaluated., Methods: We conducted a cohort study including patients ≥18 years, hospitalised between 2020 and 02-01 and 2022-10-15 with a SARS-CoV-2 positive test, from nine countries. Variant was classified based on sequenced viruses or from national public metadata. Mortality was compared using the cumulative incidence function and subdistribution hazard ratios (SHR) adjusted for age, sex, calendar time, and comorbidities. Results were shown age-stratified due to effect measure modification ( P < 0.0001 for interaction between age and variant)., Findings: We included 38,585 participants: 19,763 Wild-type, 6387 Alpha, 3640 Delta, and 8795 Omicron. The cumulative incidence of mortality decreased throughout the study period. Among participants ≥70 years, the adjusted SHR (95% confidence interval) for Delta vs. Omicron was 1.66 (1.29-2.13). This estimate was 1.66 (1.17-2.36) for Alpha vs. Omicron, and 1.34 (0.92-1.95) for Wild-type vs. Omicron. These were 1.21 (0.81-1.82), 1.21 (0.68-2.17), and 0.98 (0.53-1.82) among unvaccinated participants. When comparing Omicron sublineages, the aSHR for BA.1 was 1.92 (1.43-2.58) compared to BA.2 and 1.52 (1.11-2.08) compared to BA.5., Interpretation: The herein observed decrease in in-hospital mortality seems to reflect a combined effect of immunity from vaccinations and previous infections, although differences in virulence between SARS-CoV-2 variants may also have contributed., Funding: European Union's Horizon Europe Research and Innovation Programme., Competing Interests: Anders Sönnerborg received grants for institutions from Gilead Sciences and GSK and consulting fees and speaker's honoraria from AstraZeneca, Moderna, GSK, Gilead Sciences, and MSD, all out of the present work. Björn-Erik Ole Jensen received consulting fees and speaker's honoraria from GSK, ViiV Healthcare, Gilead Sciences, MSD, Pfizer, AstraZeneca, Janssen-Cilag, Fresenius Medical Care and Falk Foundation, as well as support for attending meetings and travel from Gilead Sciences, all out of the present work. Milosz Parczewski received honoraria for presentation from Gilead Sciences, Abbvie, MSD, Janssen-Cilag, Roche, GSK, Virology Education, and Pfizer. Maurizio Zazzi received grants for institutions from Gilead Sciences, MSD, Theratechnologies and ViiV Healthcare and consulting fees and speaker's honoraria from GSK, Gilead Sciences, MSD and ViiV Healthcare, all out of the present work. All other authors reported no conflicts of interest., (© 2024 The Author(s).)
Published: 2024
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39. SARS-CoV-2 trends in Italy, Germany and Portugal and school opening during the period of Omicron variant dominance: A quasi experimental study in the EuCARE project.

Author: Bellerba F, Bardeck N, Boehm M, D'Ecclesiis O, Raimondi S, Tomezzoli E, Miranda MS, Alves IM, Alves D, Abecasis A, Gabellone V, Gabrielli E, Vaglio G, Shamsara E, Pfeifer N, Mommo C, Incardona F, Kaiser R, and Gandini S
Subjects: Adult, Humans, Portugal epidemiology, Prospective Studies, SARS-CoV-2, Germany epidemiology, Italy epidemiology, Schools, COVID-19 epidemiology
Abstract: Objectives: We investigated the impact of school reopening on SARS-CoV-2 transmission in Italy, Germany, and Portugal in autumn 2022 when the Omicron variant was prevalent., Methods: A prospective international study was conducted using the case reproduction number (R c ) calculated with the time parametrization of Omicron. For Germany and Italy, staggered difference-in-differences analysis was employed to explore the causal relationship between school reopening and R c changes, accounting for varying reopening dates. In Portugal, interrupted time series analysis was used due to simultaneous school reopenings. Multivariable models were adopted to adjust for confounders., Results: In Italy and Germany, post-reopening R c estimates were significantly lower compared to those from regions/states that had not yet reopened at the same time points, both in the student population (overall average treatment effect for the treated subpopulation [O-ATT]: -0.80 [95% CI: -0.94;-0.66] for Italy; O-ATT-0.30 [95% CI: -0.36;-0.23] for Germany) and the adult population (O-ATT: -0.04 [95% CI: -0.07;-0.01] for Italy; O-ATT: -0.07 [95% CI: -0.11;-0.03] for Germany). In Portugal, there was a significant decreasing trend in R c following school reopenings compared to the pre-reopening period (sustained effect: -0.03 [95% CI: -0.04; -0.03] in students; -0.02 [95% CI: -0.03; -0.02] in adults)., Conclusions: We found no evidence of a causal relationship between school reopenings in autumn 2022 and Omicron SARS-CoV-2 transmission., Competing Interests: Declaration of competing interest The authors have no competing interests to declare., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Published: 2024
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40. The Role of Late Presenters in HIV-1 Transmission Clusters in Europe.

Author: Miranda MNS, Pimentel V, Gomes P, Martins MDRO, Seabra SG, Kaiser R, Böhm M, Seguin-Devaux C, Paredes R, Bobkova M, Zazzi M, Incardona F, Pingarilho M, and Abecasis AB
Subjects: Male, Humans, Adult, Female, Homosexuality, Male, Lipopolysaccharides, Cluster Analysis, Europe epidemiology, Phylogeny, HIV-1 genetics, HIV Infections, Sexual and Gender Minorities, HIV Seropositivity
Abstract: Background: Investigating the role of late presenters (LPs) in HIV-1 transmission is important, as they can contribute to the onward spread of HIV-1 virus before diagnosis, when they are not aware of their HIV status., Objective: To characterize individuals living with HIV-1 followed up in Europe infected with subtypes A, B, and G and to compare transmission clusters (TC) in LP vs. non-late presenter (NLP) populations., Methods: Information from a convenience sample of 2679 individuals living with HIV-1 was collected from the EuResist Integrated Database between 2008 and 2019. Maximum likelihood (ML) phylogenies were constructed using FastTree. Transmission clusters were identified using Cluster Picker. Statistical analyses were performed using R., Results: 2437 (91.0%) sequences were from subtype B, 168 (6.3%) from subtype A, and 74 (2.8%) from subtype G. The median age was 39 y/o (IQR: 31.0-47.0) and 85.2% of individuals were males. The main transmission route was via homosexual (MSM) contact (60.1%) and 85.0% originated from Western Europe. In total, 54.7% of individuals were classified as LPs and 41.7% of individuals were inside TCs. In subtype A, individuals in TCs were more frequently males and natives with a recent infection. For subtype B, individuals in TCs were more frequently individuals with MSM transmission route and with a recent infection. For subtype G, individuals in TCs were those with a recent infection. When analyzing cluster size, we found that LPs more frequently belonged to small clusters (<8 individuals), particularly dual clusters (2 individuals)., Conclusion: LP individuals are more present either outside or in small clusters, indicating a limited role of late presentation to HIV-1 transmission.
Published: 2023
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41. EuCARE-hospitalised study protocol: a cohort study of patients hospitalised with COVID-19 in the EuCARE project.

Author: Hedberg P, Varisco B, Bai F, Sönnerborg A, Naucler P, Pfeifer N, Cozzi-Lepri A, Ceccherini-Silberstein F, Naumovas D, Drobniewski F, Jensen BO, Toscano C, Parczewski M, Quintanares GHR, Mwau M, Pinto JA, Incardona F, Mommo C, and Marchetti G
Subjects: Adult, Aged, Humans, Cohort Studies, Multicenter Studies as Topic, Retrospective Studies, SARS-CoV-2, Treatment Outcome, COVID-19, Vaccines
Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), can lead to hospitalisation, particularly in elderly, immunocompromised, and non-vaccinated or partially vaccinated individuals. Although vaccination provides protection, the duration of this protection wanes over time. Additional doses can restore immunity, but the influence of viral variants, specific sequences, and vaccine-induced immune responses on disease severity remains unclear. Moreover, the efficacy of therapeutic interventions during hospitalisation requires further investigation. The study aims to analyse the clinical course of COVID-19 in hospitalised patients, taking into account SARS-CoV-2 variants, viral sequences, and the impact of different vaccines. The primary outcome is all-cause in-hospital mortality, while secondary outcomes include admission to intensive care unit and length of stay, duration of hospitalisation, and the level of respiratory support required., Methods: This ongoing multicentre study observes hospitalised adult patients with confirmed SARS-CoV-2 infection, utilising a combination of retrospective and prospective data collection. It aims to gather clinical and laboratory variables from around 35,000 patients, with potential for a larger sample size. Data analysis will involve biostatistical and machine-learning techniques. Selected patients will provide biological material. The study started on October 14, 2021 and is scheduled to end on October 13, 2026., Discussion: The analysis of a large sample of retrospective and prospective data about the acute phase of SARS CoV-2 infection in hospitalised patients, viral variants and vaccination in several European and non-European countries will help us to better understand risk factors for disease severity and the interplay between SARS CoV-2 variants, immune responses and vaccine efficacy. The main strengths of this study are the large sample size, the long study duration covering different waves of COVID-19 and the collection of biological samples that allows future research., Trial Registration: The trial has been registered on ClinicalTrials.gov. The unique identifier assigned to this trial is NCT05463380., (© 2023. BioMed Central Ltd., part of Springer Nature.)
Published: 2023
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42. EuCARE-POSTCOVID Study: a multicentre cohort study on long-term post-COVID-19 manifestations.

Author: Varisco B, Bai F, De Benedittis S, Tavelli A, Cozzi-Lepri A, Sala M, Miraglia FG, Santoro MM, Ceccherini-Silberstein F, Shimoni Y, Ravid S, Kozlovski T, König F, Pfeifer N, Shamsara E, Parczewski M, Monforte AD, Incardona F, Mommo C, and Marchetti G
Subjects: Female, Humans, Cohort Studies, Fatigue epidemiology, Fatigue etiology, Post-Acute COVID-19 Syndrome, Prospective Studies, Quality of Life, Retrospective Studies, Male, COVID-19 epidemiology, SARS-CoV-2
Abstract: Background: Post-COVID-19 condition refers to persistent or new onset symptoms occurring three months after acute COVID-19, which are unrelated to alternative diagnoses. Symptoms include fatigue, breathlessness, palpitations, pain, concentration difficulties ("brain fog"), sleep disorders, and anxiety/depression. The prevalence of post-COVID-19 condition ranges widely across studies, affecting 10-20% of patients and reaching 50-60% in certain cohorts, while the associated risk factors remain poorly understood., Methods: This multicentre cohort study, both retrospective and prospective, aims to assess the incidence and risk factors of post-COVID-19 condition in a cohort of recovered patients. Secondary objectives include evaluating the association between circulating SARS-CoV-2 variants and the risk of post-COVID-19 condition, as well as assessing long-term residual organ damage (lung, heart, central nervous system, peripheral nervous system) in relation to patient characteristics and virology (variant and viral load during the acute phase). Participants will include hospitalised and outpatient COVID-19 patients diagnosed between 01/03/2020 and 01/02/2025 from 8 participating centres. A control group will consist of hospitalised patients with respiratory infections other than COVID-19 during the same period. Patients will be followed up at the post-COVID-19 clinic of each centre at 2-3, 6-9, and 12-15 months after clinical recovery. Routine blood exams will be conducted, and patients will complete questionnaires to assess persisting symptoms, fatigue, dyspnoea, quality of life, disability, anxiety and depression, and post-traumatic stress disorders., Discussion: This study aims to understand post-COVID-19 syndrome's incidence and predictors by comparing pandemic waves, utilising retrospective and prospective data. Gender association, especially the potential higher prevalence in females, will be investigated. Symptom tracking via questionnaires and scales will monitor duration and evolution. Questionnaires will also collect data on vaccination, reinfections, and new health issues. Biological samples will enable future studies on post-COVID-19 sequelae mechanisms, including inflammation, immune dysregulation, and viral reservoirs., Trial Registration: This study has been registered with ClinicalTrials.gov under the identifier NCT05531773., (© 2023. BioMed Central Ltd., part of Springer Nature.)
Published: 2023
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43. Cohort Profile: A European Multidisciplinary Network for the Fight against HIV Drug Resistance (EuResist Network).

Author: Rossetti B, Incardona F, Di Teodoro G, Mommo C, Saladini F, Kaiser R, Sönnerborg A, Lengauer T, and Zazzi M
Abstract: The EuResist cohort was established in 2006 with the purpose of developing a clinical decision-support tool predicting the most effective antiretroviral therapy (ART) for persons living with HIV (PLWH), based on their clinical and virological data. Further to continuous extensive data collection from several European countries, the EuResist cohort later widened its activity to the more general area of antiretroviral treatment resistance with a focus on virus evolution. The EuResist cohort has retrospectively enrolled PLWH, both treatment-naïve and treatment-experienced, under clinical follow-up from 1998, in nine national cohorts across Europe and beyond, and this article is an overview of its achievement. A clinically oriented treatment-response prediction system was released and made available online in 2008. Clinical and virological data have been collected from more than one hundred thousand PLWH, allowing for a number of studies on the response to treatment, selection and spread of resistance-associated mutations and the circulation of viral subtypes. Drawing from its interdisciplinary vocation, EuResist will continue to investigate clinical response to antiretroviral treatment against HIV and monitor the development and circulation of HIV drug resistance in clinical settings, along with the development of novel drugs and the introduction of new treatment strategies. The support of artificial intelligence in these activities is essential.
Published: 2023
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44. Correction: European Cohorts of patients and schools to Advance Response to Epidemics (EuCARE): a cluster randomised interventional and observational study protocol to investigate the relationship between schools and SARS-CoV-2 infection.

Author: Raimondi S, Gandini S, Rubio Quintanares GH, Abecasis A, Lopalco PL, D'Ecclesiis O, Chiocca S, Tomezzoli E, Cutica I, Mazzoni D, Amparo N, Pingarilho M, Carmagnola D, Dellavia C, Zuccotti G, Ronchini C, Bellerba F, Dewald F, Kaiser R, and Incardona F
Published: 2023
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45. European Cohorts of patients and schools to Advance Response to Epidemics (EuCARE): a cluster randomised interventional and observational study protocol to investigate the relationship between schools and SARS-CoV-2 infection.

Author: Raimondi S, Gandini S, Rubio Quintanares GH, Abecasis A, Lopalco PL, D'Ecclesiis O, Chiocca S, Tomezzoli E, Cutica I, Mazzoni D, Amparo N, Pingarilho M, Carmagnola D, Dellavia C, Zuccotti G, Ronchini C, Bellerba F, Dewald F, Kaiser R, and Incardona F
Subjects: Child, Humans, SARS-CoV-2, Pandemics prevention & control, Disease Outbreaks, Schools, Randomized Controlled Trials as Topic, Multicenter Studies as Topic, Observational Studies as Topic, COVID-19 epidemiology, COVID-19 prevention & control
Abstract: Background: Contradictory results were reported on the role of school closure/reopening on the overall SARS-CoV-2 transmission rate, as well as on which kind and level of mitigation measures implemented in schools may be effective in limiting its diffusion. Some recent studies were reassuring, showing that opening did not increase the community spread, although teachers and families are worried about the high class density. On the other hand, distance learning was associated with a negative impact on learning, sociability and psychological health, especially in vulnerable children. As it becomes clear that the SARS-CoV-2 pandemic will last for a long time, there is a high need for studies and solutions to support safe schools opening based on scientific evidence of harms and benefits. The Lolli-Methode (LM) is a strategy for epidemiological surveillance and early intervention aiming at SARS-CoV-2 outbreaks' reduction in schools, relying on polymerase chain reaction analysis of saliva samples., Methods: In this cluster randomised trial protocol, we aim to determine whether the LM is useful to support schools opening and to reduce clusters and attack rates in schools, compared with the standard of care (SoC) surveillance by public health departments. This multicenter study will enrol 440 classes (around 8800 students, teachers and other personnel) from two countries, cluster randomised to LM or SoC. The samples from the pools will be collected and tested using PCR-based techniques. Test results will be combined with questionnaires filled in by children, parents, schoolteachers, and principals, concerning ongoing mitigation measures, their perceived psychological impact and other health and socio-economic information. An ancillary observational study will be carried out to study the prevalence of SARS-CoV-2 in schools, frequencies and size of clusters and attack rates, to compare the effectiveness of the different preventive measures adopted and to evaluate psychological issues in students and teachers in relation to the pandemic's containment measures., Discussion: By the end of this study, we will have defined and characterised the applicability of the LM for SARS-CoV-2 surveillance, as well as the impact of pandemic preventive measures on children and teachers. Trial registration International Standard Randomised Controlled Trial Number: NCT05396040, 27.05.2022., (© 2022. The Author(s).)
Published: 2023
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46. Analysis of mutational history of multidrug-resistant genotypes with a mutagenetic tree model.

Author: Pirkl M, Büch J, Devaux C, Böhm M, Sönnerborg A, Incardona F, Abecasis A, Vandamme AM, Zazzi M, Kaiser R, Lengauer T, and The EuResist Network Study Group
Subjects: Humans, Anti-HIV Agents pharmacology, Anti-HIV Agents therapeutic use, Genotype, Mutation, Reverse Transcriptase Inhibitors pharmacology, Reverse Transcriptase Inhibitors therapeutic use, Drug Resistance, Viral genetics, HIV Infections drug therapy, HIV-1 genetics
Abstract: Human immunodeficiency virus (HIV) can develop resistance to all antiretroviral drugs. Multidrug resistance, however, is a rare event in modern HIV treatment, but can be life-threatening, particular in patients with very long therapy histories and in areas with limited access to novel drugs. To understand the evolution of multidrug resistance, we analyzed the EuResist database to uncover the accumulation of mutations over time. We hypothesize that the accumulation of resistance mutations is not acquired simultaneously and randomly across viral genotypes but rather tends to follow a predetermined order. The knowledge of this order might help to elucidate potential mechanisms of multidrug resistance. Our evolutionary model shows an almost monotonic increase of resistance with each acquired mutation, including less well-known nucleoside reverse transcriptase (RT) inhibitor-related mutations like K223Q, L228H, and Q242H. Mutations within the integrase (IN) (T97A, E138A/K G140S, Q148H, N155H) indicate high probability of multidrug resistance. Hence, these IN mutations also tend to be observed together with mutations in the protease (PR) and RT. We followed up with an analysis of the mutation-specific error rates of our model given the data. We identified several mutations with unusual rates (PR: M41L, L33F, IN: G140S). This could imply the existence of previously unknown virus variants in the viral quasispecies. In conclusion, our bioinformatics model supports the analysis and understanding of multidrug resistance., (© 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.)
Published: 2023
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47. Molecular Epidemiology of HIV-1 in Eastern Europe and Russia.

Author: van de Klundert MAA, Antonova A, Di Teodoro G, Ceña Diez R, Chkhartishvili N, Heger E, Kuznetsova A, Lebedev A, Narayanan A, Ozhmegova E, Pronin A, Shemshura A, Tumanov A, Pfeifer N, Kaiser R, Saladini F, Zazzi M, Incardona F, Bobkova M, and Sönnerborg A
Subjects: Male, Humans, Drug Resistance, Viral genetics, Molecular Epidemiology, Homosexuality, Male, Reverse Transcriptase Inhibitors therapeutic use, Nucleosides therapeutic use, Phylogeny, Mutation, Europe, Eastern epidemiology, Protease Inhibitors therapeutic use, RNA-Directed DNA Polymerase genetics, Integrases genetics, Peptide Hydrolases genetics, HIV-1 genetics, Sexual and Gender Minorities, HIV Infections drug therapy, HIV Infections epidemiology, HIV Seropositivity
Abstract: The HIV epidemic in Eastern Europe and Russia is large and not well-controlled. To describe the more recent molecular epidemiology of HIV-1, transmitted drug resistance, and the relationship between the epidemics in this region, we sequenced the protease and reverse transcriptase genes of HIV-1 from 812 people living with HIV from Ukraine ( n = 191), Georgia ( n = 201), and Russia ( n = 420) before the initiation of antiretroviral therapy. In 190 Ukrainian patients, the integrase gene sequence was also determined. The most reported route of transmission was heterosexual contact, followed by intravenous drug use, and men having sex with men (MSM). Several pre-existing drug resistance mutations were found against non-nucleoside reverse transcriptase inhibitors (RTIs) ( n = 103), protease inhibitors ( n = 11), and nucleoside analogue RTIs ( n = 12), mostly polymorphic mutations or revertants. In the integrase gene, four strains with accessory integrase strand transfer inhibitor mutations were identified. Sub-subtype A6 caused most of the infections (713/812; 87.8%) in all three countries, including in MSM. In contrast to earlier studies, no clear clusters related to the route of transmission were identified, indicating that, within the region, the exchange of viruses among the different risk groups may occur more often than earlier reported.
Published: 2022
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48. Effectiveness of integrase strand transfer inhibitors in HIV-infected treatment-experienced individuals across Europe.

Author: Rossetti B, Fabbiani M, Di Carlo D, Incardona F, Abecasis A, Gomes P, Geretti AM, Seguin-Devaux C, Garcia F, Kaiser R, Modica S, Shallvari A, Sönnerborg A, and Zazzi M
Subjects: Drug Resistance, Viral, Europe, Heterocyclic Compounds, 3-Ring therapeutic use, Humans, Integrases therapeutic use, Oxazines therapeutic use, Viral Load, HIV Infections drug therapy, HIV Integrase genetics, HIV Integrase Inhibitors pharmacology, HIV Integrase Inhibitors therapeutic use
Abstract: Objectives: To explore the effectiveness and durability of integrase strand transfer inhibitor (INSTI)-based regimens in pre-treated subjects., Methods: Treatment-experienced individuals starting an INSTI-based regimen during 2012-2019 were selected from the INTEGRATE collaborative study. The time to virological failure [VF: one measurement of viral load (VL) ≥ 1000 copies/mL or two ≥ 50 copies/ml or one VL measurement ≥ 50 copies/mL followed by treatment change] and to INSTI discontinuation were evaluated., Results: Of 13 560 treatments analysed, 4284 were from INSTI-naïve, non-viraemic (IN-NV) individuals, 1465 were from INSTI-naïve, viraemic (IN-V) individuals, 6016 were from INSTI-experienced, non-viraemic (IE-NV) individuals and 1795 were from INSTI-experienced, viraemic (IE-V) individuals. Major INSTI drug resistance mutations (DRMs) were previously detected in 4/519 (0.8%) IN-NV, 3/394 (0.8%) IN-V, 7/1510 (0.5%) IE-NV and 25/935 (2.7%) IE-V individuals. The 1-year estimated probabilities of VF were 3.1% [95% confidence interval (CI): 2.5-3.8] in IN-NV, 18.4% (95% CI: 15.8-21.2) in IN-V, 4.2% (95% CI: 3.6-4.9) in IE-NV and 23.9% (95% CI: 20.9-26.9) in IE-V subjects. The 1-year estimated probabilities of INSTI discontinuation were 12.1% (95% CI: 11.1-13.0) in IN-NV, 19.6% (95% CI: 17.5-21.6) in IN-V, 10.8% (95% CI: 10.0-11.6) in IE-NV and 21.7% (95% CI: 19.7-23.5) in IE-V subjects., Conclusions: Both VF and INSTI discontinuation occur at substantial rates in viraemic subjects. Detection of DRMs in a proportion of INSTI-experienced individuals makes INSTI resistance testing mandatory after failure., (© 2022 British HIV Association.)
Published: 2022
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49. Early versus delayed antiretroviral therapy based on genotypic resistance test: Results from a large retrospective cohort study.

Author: Bavaro DF, De Vito A, Pasculli G, Bouba Y, Magnasco L, Pincino R, Saladini F, Lattanzio R, Corsini R, Arima S, Zazzi M, Incardona F, Rossetti B, Bezenchek A, Vanni B, and Di Biagio A
Subjects: Anti-Retroviral Agents pharmacology, Anti-Retroviral Agents therapeutic use, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Drug Resistance, Viral genetics, Female, Humans, Male, Retrospective Studies, Viral Load, Anti-HIV Agents pharmacology, Anti-HIV Agents therapeutic use, HIV Infections drug therapy, HIV-1 genetics
Abstract: Rapid start of antiretroviral therapy (ART) pending genotypic resistance test (GRT) has been recently proposed, but the effectiveness of this strategy is still debated. The rate of virological success (VS), defined as HIV-RNA < 50 copies/ml, with and without GRT was compared in drug-naïve individuals enrolled in the Italian ARCA cohort who started ART between 2015 and 2018. 521 individuals started ART: 397 without GRT (pre-GRT group) and 124 following GRT (post-GRT group). Overall, 398 (76%) were males and 30 (6%) were diagnosed with AIDS. In the pre-GRT group, baseline CD4+ cell counts were lower (p < 0.001), and viral load was higher (p < 0.001) than in the post-GRT group. The estimated probability of VS in pre-GRT versus post-GRT group was 72.54% (CI 95 : 67.78-76.60) versus 66.94% (CI 95 : 57.53-74.26) at Week 24 and 92.40% (CI 95 : 89.26-94.62) versus 92.92% (CI 95 : 86.35-96.33) at Week 48, respectively (p = 0.434). At Week 48, VS was less frequent among individuals with baseline CD4+ cell counts <200 versus >500 (90.33% vs. 97.33%), log viral load <5.00 versus >5.70 log 10 cps/ml (97.17% vs 78.16%; p < 0.001), and those treated with protease inhibitors or non-nucleoside reverse transcriptase inhibitors versus those treated with integrase strand transfer inhibitors (p < 0.001). The rate of VS does not seem to be affected by an early ART initiation pending GRT results, but it could be influenced by the composition of the ART regimen, as well as immuno-virological parameters., (© 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.)
Published: 2022
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50. Predictors of Virological Failure Among People Living with HIV Switching from an Effective First-Line Antiretroviral Regimen.

Author: Magnasco L, Pincino R, Pasculli G, Bouba Y, Saladini F, Bavaro DF, De Vito A, Lattanzio R, Corsini R, Zazzi M, Incardona F, Rossetti B, Bezenchek A, Borghi V, and Di Biagio A
Subjects: Adult, Anti-Retroviral Agents therapeutic use, Cohort Studies, Female, Humans, Male, Protease Inhibitors therapeutic use, Viral Load, Anti-HIV Agents therapeutic use, HIV Infections drug therapy
Abstract: Aim of this study was to assess the predictors of virological failure (VF) among patients living with HIV (PLWHIV) switching from an effective first-line antiretroviral therapy (ART) regimen, and to evaluate the emergence of resistance-associated mutations. All adult patients enrolled in the Antiviral Response Cohort Analysis cohort who started ART after 2010, with at least 6 months of virological suppression (VS) before ART switch and with an available genotypic resistance test (GRT) at baseline were included. Thirty-two patients out of the 607 PLWHIV included (5.3%) experienced VF after a median of 11 months from ART switch. Younger age (adjusted Hazard Ratio [aHR] 0.96, 95% confidence interval [CI] 0.92-0.99, p = .023), being male who have sex with male (aHR 0.15, 95% CI 0.03-0.69, p = .014), and longer time from VS to ART switch (aHR 0.97, 95% CI 0.95-1.00, p = .021) resulted protective toward VF, while receiving a first-line regimen containing a backbone other than ABC/3TC or TXF/FTC (aHR 3.61, 95% CI 1.00-13.1, p = .050) and a boosted protease inhibitor as anchor drug (aHR 3.34, 95% CI 1.20-9.28, p = .021) were associated with higher risk of VF. GRT at the moment of VF was available only for 13 patients (40.6%). ART switch in patients with stable control of HIV infection is a safe practice, even if particular attention should be paid in certain cases of patients switching from regimens containing low-performance backbones or protease inhibitors.
Published: 2022
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