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Abstract. The study was carried out in the patients with bulky masses in the liver. Acute hepatic failure was initiated by resection of the liver. In the patients with bulky masses in the liver, increased serum levels of the common cytokines were detected during postoperative period. The blood contents of IL-1β and IL-6 are directly dependent on the surgery-related factors (extent of resection, duration of hepatoduodenal ligation, blood loss volume), that may be employed for prediction of disease course and planning surgical treatment. Determination of a level IL-1β and IL-6 levels is a diagnostic index of liver damage, and it may be used for evaluation of the postresection hepatic failure.