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1. Post-coronavirus disease 2019 polyneuropathy with significant response to immunoglobulin therapy: a case report

Author

A. Saleh, R. Jung, S. Tonner, F. Hornof, and M. Strittmatter

Subjects
COVID-19, Neuropathy, Post-COVID-19 syndrome, Case report, Medicine
Abstract

Abstract Background The symptoms of coronavirus disease 2019, caused by the novel severe acute respiratory syndrome coronavirus 2, were originally assumed to be mainly respiratory. With increasing knowledge, however, it turned out that the spectrum of complaints varies broadly with age and concomitant diseases. While many neurological symptoms were reported in the context of the disease, ranging from permanent fatigue to recurrent headaches and concentration disturbance, treatment approaches are still in development. This case discusses a possible treatment approach with immunoglobulin therapy and its outcomes. Case presentation We present the case of a 56-year-old Caucasian female patient who, following coronavirus disease 2019, developed peripheral sensory and autonomic disturbances that fell within subacute demyelinating neuropathy. Because a significant improvement in symptoms as well as in the results of clinical and electrophysiological examination was reported after immunoglobulin therapy, long-term therapy does not appear to be necessary. Conclusion Given the significant subjective and objective improvement reported, this case provides additional evidence that immunoglobulin therapy can be considered in post-coronavirus disease 2019 syndrome.

Published
2021
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2. Post-coronavirus disease 2019 polyneuropathy with significant response to immunoglobulin therapy: a case report

Author

S Tonner, A Saleh, R Jung, F Hornof, and M Strittmatter

Subjects
Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Context (language use), Case Report, Disease, Polyneuropathies, Surgical oncology, Medicine, Humans, Respiratory system, Post-COVID-19 syndrome, business.industry, SARS-CoV-2, Immunization, Passive, COVID-19, General Medicine, Objective Improvement, Middle Aged, medicine.disease, Neuropathy, Concomitant, Female, business, Polyneuropathy
Abstract

Background The symptoms of coronavirus disease 2019, caused by the novel severe acute respiratory syndrome coronavirus 2, were originally assumed to be mainly respiratory. With increasing knowledge, however, it turned out that the spectrum of complaints varies broadly with age and concomitant diseases. While many neurological symptoms were reported in the context of the disease, ranging from permanent fatigue to recurrent headaches and concentration disturbance, treatment approaches are still in development. This case discusses a possible treatment approach with immunoglobulin therapy and its outcomes. Case presentation We present the case of a 56-year-old Caucasian female patient who, following coronavirus disease 2019, developed peripheral sensory and autonomic disturbances that fell within subacute demyelinating neuropathy. Because a significant improvement in symptoms as well as in the results of clinical and electrophysiological examination was reported after immunoglobulin therapy, long-term therapy does not appear to be necessary. Conclusion Given the significant subjective and objective improvement reported, this case provides additional evidence that immunoglobulin therapy can be considered in post-coronavirus disease 2019 syndrome.

Published
2021

3. Clinical Nephrology - Epidemiology II

Author

H. Agnes, P. Kalman, A. Jozsef, B. Henrik, I. Mucsi, K. Kamata, T. Sano, S. Naito, T. Okamoto, C. Okina, M. Kamata, J. Murano, K. Kobayashi, M. Uchida, T. Aoyama, Y. Takeuchi, Y. Nagaba, H. Sakamoto, C. Torino, V. Panuccio, A. Clementi, M. Garozzo, G. Bonanno, R. Boito, G. Natale, T. Cicchetti, A. Chippari, D. Logozzo, G. Alati, S. Cassani, A. Sellaro, G. D'arrigo, G. Tripepi, A. Roberta, M. Postorino, F. Mallamaci, C. Zoccali, E. Buonanno, S. Brancaccio, V. Fimiani, P. Napolitano, R. Spadola, L. Morrone, B. DI Iorio, D. Russo, A. Betriu, M. Martinez-Alonso, T. Vidal, J. Valdivielso, E. Fernandez, F. Bernadette, B. Jean-Baptiste, L. Frimat, N. D. Madala, G. P. Thusi, N. Sibisi, B. G. Mazibuko, A. G. H. Assounga, N.-C. Tsai, H.-H. Wang, Y.-C. Chen, C.-C. Hung, S.-J. Hwang, H.-C. Chen, P. Branco, T. Adragao, R. Birne, A. R. Martins, R. Vizinho, A. Gaspar, M. J. Grilo, J. D. Barata, D. Bonhorst, P. Adragao, J. S. Kim, J. W. Yang, M. K. Kim, S. O. Choi, B. G. Han, N. Nathalie, E. Sunny, G. Glorieux, B. Daniela, B. Fellype, L. Sophie, L. Horst D, M. Ziad, V. Raymond, M. Yanai, K. Okada, K. Takeuchi, K. Nitta, S. Takahashi, M. Morena, I. Jaussent, A. Halkovich, A.-M. Dupuy, A.-S. Bargnoux, L. Chenine, H. Leray-Moragues, K. Klouche, H. Vernhet, B. Canaud, J.-P. Cristol, A. Shutov, V. Serov, J. Kuznetsova, M. Menzorov, D. Serova, L. Petrescu, A. Zugravu, C. Capusa, S. Stancu, S. Cinca, C. Anghel, D. Timofte, L. Medrihan, D. Ionescu, G. Mircescu, T.-W. Hsu, K.-L. Kuo, S.-C. Hung, D.-C. Tarng, S. Lee, I. Kim, D. Lee, H. Rhee, S. Song, E. Seong, I. Kwak, M. Holzmann, C. Gardell, A. Jeppsson, U. Sartipy, Y. Solak, M. I. Yilmaz, K. Caglar, M. Saglam, H. Yaman, A. Sonmez, H. U. Unal, M. Gok, A. Gaipov, M. Kayrak, T. Eyileten, S. Turk, A. Vural, L. DI Lullo, F. Floccari, R. Rivera, A. Granata, A. D'amelio, F. Logias, G. Otranto, M. Malaguti, A. Santoboni, F. Fiorini, T. Connor, D. Oygar, D. Nitsch, D. Gale, R. Steenkamp, G. H. Neild, P. Maxwell, I. Louise Hogsbro, B. Redal-Baigorri, B. Sautenet, J. M. Halimi, A. Caille, P. Goupille, B. Giraudeau, Y. Oguz, M. Yenicesu, H. Cetinkaya, Y. Ishimoto, T. Ohki, M. Sugahara, T. Kanemitsu, M. Kobayashi, L. Uchida, N. Kotera, S. Tanaka, T. Sugimoto, N. Mise, N. Miyazaki, J. Matsumoto, I. Murata, G. Yoshida, K. Morishita, H. Ushikoshi, K. Nishigaki, S. Ogura, S. Minatoguchi, R. Harvey, A. Ala, D. Banerjee, C. Farmer, J. Irving, H. Hobbs, T. Wheeler, B. Klebe, P. Stevens, G. Selim, O. Stojceva-Taneva, L. Tozija, N. Stojcev, S. Gelev, P. Dzekova-Vidimliski, S. Pavleska, A. Sikole, A. R. Qureshi, M. Evans, M. Stendahl, K. G. Prutz, C. G. Elinder, K. Tamagaki, H. Kado, M. Nakata, T. Kitani, N. Ota, R. Ishida, E. Matsuoka, Y. Shiotsu, M. Ishida, Y. Mori, M. Christelle, N. Rognant, D. Evelyne, F. Sophie, J. Laurent, L. Maurice, R. Silverwood, M. Pierce, D. Kuh, C. Savage, C. Ferro, D. G. Moniek, M. De Goeij, H. Nynke, O. Gurbey, R. Joris, D. Friedo, P. Clayton, B. Grace, A. Cass, S. Mcdonald, V. Lorenzo, M. Martin Conde, A. Dusso, J. M. Valdivielso, D. P. Roggeri, G. Cannella, M. Cozzolino, S. Mazzaferro, P. Messa, D. Brancaccio, R. De Souza Faria, N. Fernandes, J. Lovisi, M. Moura Marta, M. Reboredo, B. Do Vale Pinheiro, M. Bastos, F. Hundt, S. Pabst, C. Hammerstingl, T. Gerhardt, D. Skowasch, R. Woitas, A. A. Lopes, L. F. Silva, C. M. Matos, M. S. Martins, F. A. Silva, G. B. Lopes, F. Pizzarelli, P. Dattolo, S. Michelassi, C. Rossi, S. Bandinelli, M. Mieth, R. Mass, L. Ferrucci, S. Parisi, S. Arduino, R. Attini, F. Fassio, M. Biolcati, A. Pagano, C. Bossotti, M. Ferraresi, P. Gaglioti, T. Todros, G. B. Piccoli, T. M. Salgado, B. Arguello, S. I. Benrimoj, F. Fernandez-Llimos, P. Bailey, C. Tomson, Y. Ben-Shlomo, A. Santoro, P. Rucci, M. Mandreoli, F. Caruso, M. Corradini, M. Flachi, D. Gibertoni, A. Rigotti, G. Russo, M. Fantini, H. S. Mahapatra, S. Choudhury, G. Buxi, N. Sharma, Y. Gupta, V. Sekhar, N. Yanagisawa, M. Ando, A. Ajisawa, K. Tsuchiya, O. Janusz, M. Mikolaj, M. Jacek, R. Boleslaw, S. Prakash, R. Coffin, J. Schold, D. Einstadter, S. Stark, D. Rodgers, M. Howard, A. Sehgal, S. Palmer, A. Tong, B. Manns, J. Craig, M. Ruospo, L. Gargano, G. Strippoli, M. Vecchio, M. Petruzzi, M. De Benedictis, F. Pellegrini, Y. Ohno, E. Ishimura, T. Naganuma, K. Kondo, W. Fukushima, K. Mui, M. Inaba, Y. Hirota, X. Sun, S. Jiang, H. Gu, Y. Chen, C. XI, X. Qiao, X. Chen, E. Daher, G. S. Junior, C. N. Jacinto, R. S. Pimentel, G. B. R. Aguiar, C. B. Lima, R. C. Borges, L. P. C. Mota, J. V. L. Melo, S. A. Melo, V. T. Canamary, M. Alves, S. M. H. A. Araujo, Y. K. Huang, K. Rogacev, B. Cremers, A. Zawada, S. Seiler, N. Binder, P. Ege, G. Grosse-Dunker, I. Heisel, F. Hornof, J. Jeken, N. Rebling, C. Ulrich, B. Scheller, M. Bohm, D. Fliser, G. H. Heine, B. Robinson, M. Wang, B. Bieber, R. Fluck, P. G. Kerr, B. Wikstrom, M. Krishnan, A. Nissenson, R. L. Pisoni, S. Mykleset, T. B. Osthus, B. Waldum, I. Os, J. Buttigieg, A. Cassar, J. Farrugia Agius, M. Hara, M. Yamato, K. Yasuda, and K. Sasaki

Subjects
Transplantation, medicine.medical_specialty, Acute coronary syndrome, business.industry, Red blood cell distribution width, medicine.disease, Sudden death, Uremia, Nephrology, Diabetes mellitus, Internal medicine, Heart failure, medicine, Cardiology, Endothelial dysfunction, business, Kidney disease
Published
2012
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4. General & clinical epidemiology CKD 1-5 (1)

Author

S. Seiler, B. Cremers, P. Ege, M. Fehrenz, F. Hornof, J. Jeken, S. Kersting, N. M. Rebling, C. Steimle, K. S. Rogacev, B. Scheller, M. Bohm, D. Fliser, G. H. Heine, E. V. T. Nagler, A. C. Webster, R. Vanholder, C. Zoccali, S. Chinnappa, A. Mooney, M. El Nahas, L.-B. Tan, G. Lucisano, F. Bova, P. Presta, C. Caglioti, A. Caglioti, G. Fuiano, A. Ikeda, T. Konta, S. Takasaki, Y. Mashima, I. Kubota, S. Nakamura, Y. Kokubo, H. Makino, H. Takata, T. Fujii, F. Yoshihara, T. Horio, Y. Kawano, M. Badulescu, C. Capusa, S. Stancu, V. Blaga, A. Ilyes, C. Anghel, G. Mircescu, V. Tolkacheva, S. Villevalde, E. Tyukhmenev, Z. Kobalava, Y. Shalyagin, M. Shvetsov, S. Nagaytseva, L. Lukshina, E. Shilov, M. Fusaro, G. Tripepi, G. Crepaldi, S. Maggi, A. D'Angelo, A. Naso, M. Plebani, N. Vajente, S. Giannini, L. Calo, D. Miozzo, R. Cristofaro, M. Gallieni, S. Feriozzi, J. Torras, M. Cibulla, K. Nicholls, G. Sunder-Plassmann, M. West, E. Pavlikova, V. Moiseev, C.-T. Yen, C.-H. Huang, M.-C. Wang, E. Daher, G. Silva Junior, A. P. Vieira, A. Couto Bem, A. Fiqueiredo Filho, A. Lopes Filho, A. Guedes, C. Eloy Costa, J. Holanda de Souza, A. Liborio, R. Daniel, D. Nitsch, L. Harper, null EUVAS Group, M. Little, S. M. R. Khatami, M. Mahmoodian, E. Zare, M. Pashang, F. Mc Carroll, B. Cooke, M. O'Kane, K. Moles, P. Garrett, J. Lindsay, T.-M. Yu, C.-H. Chen, M.-J. Wu, C.-H. Cheng, Y.-W. Chuang, K.-H. Shu, J. C. Cole, D. Oberdhan, R. Cheng, J. Urwongse, H. Krasa, F. Czerwiec, A. Chapman, R. Perrone, O. Moranne, C. Fafin, G. Favre, S. Mougel, A. Vido, B. Seitz, P. Dahan, L. Albano, V. Esnult, M. Rama, P. Gayathri, D. A. Leelavathi, P. A. Ravindra, V. Sundaram, P. R. Nageshwar, V. Piraina, R. Talarico, G. Esposito, A. Colombo, G. Mazza, E. Cirillo, S. Quattrone, B. Marron, N. Chen, H. Shi, X. Ma, J. Zhang, P. Mao, L. He, J. Yu, X. Ding, G. Jiang, Y. Gu, W. Zhang, N. Wang, C. Mei, Z. Ni, C. Tzanno, G. Stein, F. Nisihara, J. Rocha, P. Clesca, C. Uezima, H. Langham, M. Tomlin, E. Coyne, W. Hope, C. Bebb, C. Johnson, C. Byrne, Y. Li, H. Ren, W. Wang, X. Li, X. Chen, X. Wu, B. Canver, T. Colak, S. Can, H. Karakayali, V. Bansal, R. Davis, E. Litinas, D. Hoppensteadt, I. Thethi, and J. Fareed

Subjects
Transplantation, Nephrology
Published
2011
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5. CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography.

Author

Rogacev KS, Cremers B, Zawada AM, Seiler S, Binder N, Ege P, Große-Dunker G, Heisel I, Hornof F, Jeken J, Rebling NM, Ulrich C, Scheller B, Böhm M, Fliser D, and Heine GH

Subjects
Aged, Cohort Studies, Coronary Angiography, Female, GPI-Linked Proteins metabolism, Humans, Leukocyte Count, Male, Middle Aged, Predictive Value of Tests, Regression Analysis, Risk Factors, Cardiovascular Diseases immunology, Lipopolysaccharide Receptors metabolism, Monocytes metabolism, Receptors, IgG metabolism
Abstract

Objectives: The aim of this study was to analyze the yet ill-defined relationship of distinct human monocyte subsets with cardiovascular outcomes in a broad patient population at cardiovascular risk., Background: Monocytes, the most abundant immune cell type found in atherosclerotic plaques, are crucial promoters of atherogenesis. Three distinct human monocyte subsets exist: classical CD14++CD16-, intermediate CD14++CD16+, and nonclassical CD14+CD16++ monocytes. Immunomodulation of distinct monocyte subsets has recently been discussed as a new therapeutic avenue in atherosclerosis., Methods: Cardiovascular events in 951 subjects referred for elective coronary angiography were prospectively analyzed. Monocyte subset analysis was performed using flow cytometry, blinded to patients' clinical characteristics, and patients were categorized according to quartiles of total monocyte and monocyte subset counts. The primary endpoint was defined a priori as the first occurrence of cardiovascular death, acute myocardial infarction, or nonhemorrhagic stroke. Endpoint adjudication was done blinded to monocyte subset distribution., Results: During a mean follow-up period of 2.6 ± 1.0 years, 93 patients experienced the primary endpoint. In univariate Kaplan-Meier analysis, counts of total (p = 0.010), classical CD14++CD16- (p = 0.024), and intermediate CD14++CD16+ (p < 0.001) monocytes predicted the primary endpoint, whereas nonclassical monocytes did not (p = 0.158). After full adjustment for confounders, CD14++CD16+ monocytes remained the only monocyte subset independently related to cardiovascular events (fourth vs. first quartile: hazard ratio: 3.019; 95% confidence interval: 1.315 to 6.928; p = 0.009)., Conclusions: CD14++CD16+ monocytes independently predicted cardiovascular events in subjects referred for elective coronary angiography. Future studies will be needed to elucidate whether CD14++CD16+ monocytes may become a target cell population for new therapeutic strategies in atherosclerosis., (Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

Published
2012
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6. The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation.

Author

Seiler S, Cremers B, Rebling NM, Hornof F, Jeken J, Kersting S, Steimle C, Ege P, Fehrenz M, Rogacev KS, Scheller B, Böhm M, Fliser D, and Heine GH

Subjects
Atrial Fibrillation blood, Biomarkers metabolism, Coronary Artery Disease blood, Cross-Sectional Studies, Electrocardiography, Fibroblast Growth Factor-23, Glomerular Filtration Rate physiology, Humans, Hypertrophy, Left Ventricular blood, Hypertrophy, Left Ventricular etiology, Kidney Diseases complications, Kidney Diseases physiopathology, Male, Middle Aged, Natriuretic Peptide, Brain metabolism, Peptide Fragments metabolism, Ventricular Dysfunction, Left blood, Atrial Fibrillation etiology, Calcium Phosphates metabolism, Coronary Artery Disease etiology, Fibroblast Growth Factors metabolism, Ventricular Dysfunction, Left etiology
Abstract

Aims: High serum phosphate is linked to cardiovascular morbidity and mortality in the general population. Fibroblast growth factor 23 (FGF-23) is a critical phosphate regulating hormone, potentially reflecting phosphate load better than a single serum phosphate measurement. Recent pioneering echocardiographic studies associated FGF-23 with left-ventricular morphology. However, the association between FGF-23 and left-ventricular function is unknown, prompting us to investigate this relationship in our HOM SWEET HOMe study., Methods and Results: We studied the association between C-terminal FGF-23, coronary artery disease, and left-ventricular function in 885 subjects undergoing elective coronary angiography. Left-ventricular function was assessed with ventriculography. More, pro-brain natriuretic peptide (pro-BNP) plasma levels were measured. The presence of left-ventricular hypertrophy and atrial fibrillation was assessed by electrocardiography. Patients with an ejection fraction <40% had significantly higher FGF-23 levels compared with patients with the ejection fraction >40% (P< 0.001). In multivariable regression analysis, the observed relationship between FGF-23 and left-ventricular function remained significant after adjustment for estimated glomerular filtration rate, presence of left-ventricular hypertrophy, and other confounding variables. In accordance, FGF-23 significantly correlated with pro-BNP plasma levels (r = 0.31; P< 0.001). Prevalent atrial fibrillation was associated with elevated FGF-23 levels, while the presence of coronary artery disease was not., Conclusions: Fibroblast growth factor 23 levels are associated with left-ventricular function and atrial fibrillation even in the absence of renal function impairment. Of note, these cross-sectional data cannot prove causality; therefore, future studies will have to discern whether FGF-23 exerts a direct untoward effect on the myocardium, or rather represents an 'innocent bystander' which reflects a high phosphate burden.

Published
2011
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7. Monocyte heterogeneity in obesity and subclinical atherosclerosis.

Author

Rogacev KS, Ulrich C, Blömer L, Hornof F, Oster K, Ziegelin M, Cremers B, Grenner Y, Geisel J, Schlitt A, Köhler H, Fliser D, Girndt M, and Heine GH

Subjects
Abdominal Fat pathology, Adiposity physiology, Adult, Body Mass Index, Female, Humans, Male, Middle Aged, Receptors, IgG metabolism, Tunica Intima pathology, Tunica Media pathology, Atherosclerosis pathology, Carotid Artery Diseases pathology, Carotid Artery, Common pathology, Macrophages pathology, Monocytes pathology, Obesity pathology
Abstract

Aims: Monocytes and monocyte-derived macrophages have been recognised as the cellular hallmark of atherosclerosis decades ago. Recently, they have also been shown to play a pivotal role in obesity. Monocytes display immunophenotypic heterogeneity with functionally distinct subpopulations. We initiated the I LIKE HOMe study to examine monocyte heterogeneity in obesity and subclinical atherosclerosis., Methods and Results: We assessed carotid intima media thickness (IMT), body mass index (BMI), and other cardiovascular risk factors in 622 healthy volunteers. Using flow-cytometry, we differentiated monocytes into CD14(++)CD16(-) and CD16(+) cells, which we further subdivided into CD14(++)CD16(+) and CD14((+))CD16(+) cells. Body mass index was significantly correlated with carotid IMT. High CD16(+) monocyte counts were significantly associated with both higher BMI and increased carotid IMT. Adjustment for CD16(+) monocyte counts weakened the correlation between BMI and carotid IMT, suggesting that the increase in CD16(+) monocyte numbers in obesity may partly explain the association between obesity and IMT., Conclusion: Our results reveal a significant univariate association between CD16(+) monocytes and both obesity and subclinical atherosclerosis in low-risk individuals. They are in line with recent observations that CD16(+) monocytes show high endothelial affinity and a potent capacity to invade vascular lesions and to transform into pro-inflammatory cytokine producing macrophages.

Published
2010
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