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Background Transcatheter Aortic Valve Implantation (TAVI) is a recommended therapy for patients with severe aortic stenosis in surgically high or intermediate-risk patients but during follow-up, the rate of death and re-hospitalization for cardiovascular causes remains high. Purpose The objective of this study was to evaluate left ventricular global systolic longitudinal deformation before TAVI as predictors of prognosis after. Methods 146 patients treated by TAVI between 2015 and 2016 at Nancy Hospital and in 2016 at Reims Hospital were included. The parameters studied were the global longitudinal strain (GLS), the endocardial and epicardial strain, the basal and apical regional strain, and the post systolic index (PSI). The main endpoint was cardiovascular mortality. The secondary criteria were the occurrence of a cardiovascular hospitalization and the occurrence of one or the other. Results Despite a left ventricular ejection fraction conserved at 58.8 ± 10.6%, the GLS was impaired at −16.4 ± 4.1%. The cardiovascular death rate was 9.6% (14 patients). The GLS before TAVI was predictive of cardiovascular mortality for endocardial, medial and epicardial strain with thresholds of −17%, −15% and −13% respectively with Sensitivity (Se) 64% and Specificity (Sp) 70% (P = 0.01), Se 63% Sp 70% (P = 0.006), and Se 64% Sp 70%(P = 0.008) respectively. The rate of rehospitalization for cardiovascular cause was 16.4% (24 patients). PSI was also a factor of poor prognosis for cardiovascular hospitalizations with a threshold of 10, clinically relevant and usable (P = 0.029). Conclusion Left ventricular longitudinal deformation parameters are decreased in patients with severe aortic stenosis despite a conserved LVEF. They seem to have a prognostic value for the cardiovascular mortality rate and occurrence of cardiovascular re-hospitalization after TAVI. They may have an interest in defining the delay of the beginning of treatment and follow-up to maintain after TAVI.