35 results on '"F. Fedhila"'
Search Results
2. Tumeur pédiatrique de la sphère génitale révélée par un saignement vaginal : quel est votre diagnostic ?
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Monia Khemiri, Sihem Barsoui, H. Louati, Maroua Jlassi, Samar Rhayem, Sofien Ghorbel, F. Fedhila, and A. Charieg
- Subjects
03 medical and health sciences ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,030232 urology & nephrology ,Medicine ,Surgery ,business - Published
- 2016
3. Carcinome à cellules claires du rein et sarcome d’Ewing pelvien : une association rare chez l’enfant en rapport avec la translocation TFE3 Xp11.2
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Monia Khemiri, S. Barsaoui, Samar Rhayem, Ibtissem Bellagha, F. Fedhila Ben Ayed, L. Ben Hassine, R. Doghri, and K. Mrad
- Subjects
Kidney ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,030232 urology & nephrology ,Urology ,Wilms' tumor ,medicine.disease ,Nephrectomy ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Renal cell carcinoma ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Adjuvant therapy ,medicine ,Carcinoma ,Sarcoma ,business - Abstract
Renal cell carcinoma is a rare pediatric malignant tumor of the kidney. Unlike Wilms tumor, the efficacy of chemotherapy and radiation therapy in pediatric renal cell carcinoma remains uncertain. Surgery is the best treatment and prognosis is favorable when the tumor is localized and completely eradicated. We report an exceptional observation in a 7-year-old girl with renal cell carcinoma who had been treated 20 months previously for Ewing sarcoma with chemotherapy and radiotherapy. The renal tumor was revealed by abdominal pain without hematuria. She underwent a radical nephrectomy, and histopathology concluded in renal carcinoma associated with translocation Xp 11.2 grade 3 of Furhrman pT3a N1. No adjuvant therapy was given. After 3 years of follow-up, there is no evidence of local or metastatic recurrence. This observation is significant given the very young age of this patient, the occurrence after Ewing sarcoma with a short disease-free interval. It seems that translocation renal cell carcinoma is associated with previous exposure to chemotherapy, particularly topoisomerase II inhibitors or alkylating agents.
- Published
- 2016
4. Burkitt lymphoma in a child with Bloom syndrome
- Author
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Hazem Zribi, M. Chaabouni, S. Barsaoui, M. Jelassi, Ibtissem Bellagha, Samar Rhayem, F. Fedhila-Ben Ayed, W. Douira-Khomsi, and Monia Khemiri
- Subjects
Male ,0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,03 medical and health sciences ,Fatal Outcome ,0302 clinical medicine ,Chromosome instability ,Humans ,Medicine ,Neoplasm ,Bloom syndrome ,Chemotherapy ,business.industry ,Standard treatment ,medicine.disease ,Burkitt Lymphoma ,Lymphoma ,030104 developmental biology ,Child, Preschool ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Immunology ,Facial telangiectasia ,business ,Bloom Syndrome ,Rare disease - Abstract
Summary Background Bloom syndrome is a rare disease characterized by chromosomal instability and increased risk of developing lymphoma. Observation We report on a case of Bloom syndrome in a 5-year-old boy with Burkitt lymphoma. The diagnosis was suspected by growth retardation, repeated respiratory infections, facial telangiectasia, and a low immunoglobulin level, then confirmed cytogenetically by sister chromatid exchanges. Chemotherapy was poorly tolerated, which required reducing the doses. Unfortunately, it was not sufficient to control the neoplasm and the patient died 14 months after diagnosis. Conclusions Cancers in Bloom syndrome are a challenge since the potentially life-threatening side effects of the chemotherapy may require modifications in standard treatment such as dose reduction, which can compromise the tumor prognosis.
- Published
- 2016
5. Myélinolyse centropontique chez un enfant sous chimiothérapie
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M. Mahmoud, W. Douira-Khomsi, S. Barsaoui, F. Fedhila, L. Lahmar, L. Ben Hassine, and Ibtissem Bellagha
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Pediatrics, Perinatology and Child Health - Published
- 2013
6. Recurrence, remnants and tumor progression in nephroblastoma: How far is surgery involved?
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F. Fedhila, A. Charieg, Riadh Jouini, I. Chibani, S. Rhayem, M. Marzouki, Faouzi Nouira, and S. Jlidi
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Oncology ,medicine.medical_specialty ,Tumor progression ,business.industry ,Urology ,Internal medicine ,medicine ,business ,Surgery - Published
- 2017
7. [Secondary TFE3-associated renal cell carcinoma in a child treated for Ewing sarcoma]
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F, Fedhila Ben Ayed, S, Rhayem, R, Doghri, L, Ben Hassine, M, Khemiri, K, Mrad, I, Bellagha, and S, Barsaoui
- Subjects
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ,Humans ,Bone Neoplasms ,Female ,Neoplasms, Second Primary ,Sarcoma, Ewing ,Child ,Carcinoma, Renal Cell ,Kidney Neoplasms ,Translocation, Genetic - Abstract
Renal cell carcinoma is a rare pediatric malignant tumor of the kidney. Unlike Wilms tumor, the efficacy of chemotherapy and radiation therapy in pediatric renal cell carcinoma remains uncertain. Surgery is the best treatment and prognosis is favorable when the tumor is localized and completely eradicated. We report an exceptional observation in a 7-year-old girl with renal cell carcinoma who had been treated 20 months previously for Ewing sarcoma with chemotherapy and radiotherapy. The renal tumor was revealed by abdominal pain without hematuria. She underwent a radical nephrectomy, and histopathology concluded in renal carcinoma associated with translocation Xp 11.2 grade 3 of Furhrman pT3a N1. No adjuvant therapy was given. After 3 years of follow-up, there is no evidence of local or metastatic recurrence. This observation is significant given the very young age of this patient, the occurrence after Ewing sarcoma with a short disease-free interval. It seems that translocation renal cell carcinoma is associated with previous exposure to chemotherapy, particularly topoisomerase II inhibitors or alkylating agents.
- Published
- 2015
8. P-187 – Papillomavirus Humain et vaccination: que savent les adolescents? Tumeurs rétropéritonéales et extension intra-vasculaire à propos de 14 cas pédiatriques
- Author
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I. Dziri, F. Fedhila, M. Jelassi, S. Barsaoui, W. Bennour, Monia Khemiri, S. Rhayem, Ibtissem Bellagha, and W. Douira
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
9. P-198 – Lymphome de burkitt: profil epidemiologique et évolutif a propos de 51 cas
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Ibtissem Bellagha, F. Fedhila, S. Barsaoui, W. Douira, F. Mezghani, S. Rhayem, A. Ben Mansour, and Monia Khemiri
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Pediatrics, Perinatology and Child Health - Published
- 2015
10. [High T2 signal intensity of the brainstem in a child undergoing chemotherapy]
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W, Douira-Khomsi, M, Mahmoud, F, Fedhila, L, Ben Hassine, L, Lahmar, S, Barsaoui, and I, Bellagha
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Contrast Media ,Gadolinium ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Magnetic Resonance Imaging ,Sensitivity and Specificity ,Dyspnea ,Predictive Value of Tests ,Child, Preschool ,Antineoplastic Combined Chemotherapy Protocols ,Myelinolysis, Central Pontine ,Humans ,Muscle Hypotonia ,Confusion ,Hyponatremia - Published
- 2013
11. [Centropontine myelinosis in a child undergoing chemotherapy]
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W, Douira-Khomsi, M, Mahmoud, F, Fedhila, L, Ben Hassine, L, Lahmar, S, Barsaoui, and I, Bellagha
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Predictive Value of Tests ,Child, Preschool ,Antineoplastic Combined Chemotherapy Protocols ,Myelinolysis, Central Pontine ,Contrast Media ,Humans ,Muscle Hypotonia ,Gadolinium ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Confusion ,Magnetic Resonance Imaging ,Sensitivity and Specificity ,Hyponatremia - Published
- 2013
12. Hypersignal T2 du tronc cérébral chez un enfant sous chimiothérapie
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F. Fedhila, W. Douira-Khomsi, Sihem Barsaoui, M. Mahmoud, L. Ben Hassine, Ibtissem Bellagha, and L. Lahmar
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2013
13. [Value of procalcitonin measurement in maternal fetal infection]
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Olfa, Bouyahia, N, Ncibi, F, Fedhila, N, Amdouni, J, Ben Aissa, T, Messoud, Samir, Boukthir, and Azza, Sammoud El Gharbi
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Calcitonin ,Male ,Calcitonin Gene-Related Peptide ,Infant, Newborn ,Bacterial Infections ,Sensitivity and Specificity ,Infant, Newborn, Diseases ,Infectious Disease Transmission, Vertical ,C-Reactive Protein ,Predictive Value of Tests ,Pregnancy ,Humans ,Female ,Prospective Studies ,Pregnancy Complications, Infectious ,Protein Precursors - Abstract
Materno foetal infection (MFI) remains one of the major causes of neonatal morbidity and mortality. Early detection of neonatal sepsis can be difficult, because the first signs of the disease may be unspecific and similar to symptoms of other non-infectious processes.We aimed to investigate the role of procalcitonin (PCT) in the diagnosis of fetal infection (MFI), and to compare it with those of the C-reactive protein (CRP).We have conducted a prospective study during 20 months: which concerned 25 newborns suspected of MFI and admitted before 12 hours of life. All newborn had anamnestic and/or physical signs of possible infection. MFI was confirmed in newborns with positive bacterial analysis. CRP and PCT were determined in the sera at H12, H24, H36 and H48. Newborns were divided into: patients with recognized MFI (group 1), patients with possible MFI (group2) and non infected newborns (group 3):The specificity of PCT was 80% versus 27% for the CRP. Negative predictive value of PCT was 85% versus 66% for the CRP. The mean values, at H12, H24, H36 and H48, of PCT for newborn who had MFI were statistically grater than those for no infused group (p0.05). No statistical difference was observed concerning CRP values.PCT may a useful tool in early diagnosing of MFI; it has better specificity and negative predictive value than CRP.
- Published
- 2009
14. P-195 – Rétinoblastome: Étude Tunisienne à propos pe 38 cas
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F. Fedhila, A. Chebbi, S. Barsaoui, F. Mezghani, A. Ben Mansour, Monia Khemiri, S. Jenhani, S. Rhayem, and H. Bouguila
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
15. P-186 – Papillomavirus Humain et vaccination: que savent les adolescents? Déficit immunitaire et cancer
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A. Ben Mansour, S. Rhayem, Monia Khemiri, S. Barsaoui, F. Fedhila, N. Kloula, Hazem Zribi, and F. Mezghani
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
16. P-191 – Papillomavirus Humain et vaccination: que savent les adolescents? Tumeurs thoraciques primaires à propos d'une série pédiatrique de 30 cas
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L. Ben Hassine, F. Fedhila, S. Jenhani, S. Barsaoui, Z. Ellafi, Monia Khemiri, Ibtissem Bellagha, and S. Rhayem
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Pediatrics, Perinatology and Child Health - Published
- 2015
17. P-188 – Papillomavirus Humain et vaccination: que savent les adolescents? Profil évolutif et facteurs pronostiques des néphroblastomes: À propos de 75 cas pédiatriques
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S. Rhayem, S. Barsaoui, R. Doghri, Ibtissem Bellagha, I. Dziri, K. Mrad, Monia Khemiri, M. Jelassi, Hela Louati, and F. Fedhila
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Pediatrics, Perinatology and Child Health - Published
- 2015
18. P202 - Le néphroblastome : étude tunisienne unicentrique à propos de 32 cas
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F. Oubich, Beji Chaouachi, K. Ben Romdhane, S. Barsaoui, F. Fedhila Ben Ayed, L. Dkhil, Ibtissem Bellagha, Mourad Hamzaoui, and F. Kilani
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
Objectifs Etudier a travers une serie de 32 nephrolastomes suivis a l’unite d’oncologie de l’Hopital d’enfants de Tunis, les caracteristiques epidemiologiques et cliniques de cette tumeur ainsi que les resultats therapeutiques. Patients et Methodes Il s’agit d’une etude prospective ayant collige 32 cas de nephroblastome entre le 1 er avril 2005 et le 31 decembre 2009. Le diagnostic de nephroblastome a ete retenu sur l’examen anatomopthologique de la piece operatoire. Le protocole therapeutique utili se est celui du groupe franco-africain d’oncologie pediatrique. Resultats Il existe une predominance feminine (sex ratio : 0,36). L’âge moyen de nos patients est de 3 ans et demi. Le bilan d’extension a objective des metastases chez 6 patients. Il existait dans notre serie une predominance des stades I (63 %). L’histologie etait intermediaire dans 80 % des cas, a haut risque dans 20 % des cas. Apres un recul moyen de 15mois, l’evolution a ete favorable dans 80 % des cas. Les rechutes sont survenues dans 3 cas. On a recense dans cette serie 6 deces (20 %). Conclusion Notre serie se distingue par la predominance des stades I, le pourcentage assez important d’histologie a haut risque et un faible nombre des perdus de vue. Nous soulignons la faisabilite des protocoles Europeens dans notre unite.
- Published
- 2010
19. Impact of Music Therapy on Quality of Life in Children with Cancer.
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Fedhila F, Hannachi MW, Jbebli E, Selmi I, Rhayem S, Magouri I, Bellali H, and Khemiri M
- Abstract
Background: Music therapy (MT) is a non-pharmacological treatment increasingly used to reduce stress and anxiety in hospitalized children affected by cancers. The aim of this study was to evaluate the impact of MT on quality of life in children with cancer and determine its effect on cardiorespiratory rates., Methods: We conducted a quasi-experimental study between 1 April and 31 August 2021 at Bechir Hamza children's Hospital in Tunis, including children treated for cancer. The child or parent completed the PedsQL Module Cancer French version 3.0 questionnaires before and after four weekly music therapy sessions. The child's respiratory and heart rates were measured before and after each session., Results: We included 20 children whose mean age was 7 ± 4.5 years. The median value of the total questionnaire score increased from 57 [46; 70] to 72 [67; 85] ( p < 10
-3 ) noting a significant reduction in pain ( p = 0.02), nausea ( p = 0.009), and anxiety related to medical procedures ( p = 0.009) and worry about the future ( p = 0.005). We highlighted a significant decrease in respiratory and heart rate after MT ( p < 0.05)., Conclusions: MT has positive impact on quality of life in children with cancer and reduces stress by lowering their cardiorespiratory rates.- Published
- 2023
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20. Correction: Periosteal preservation: a new technique in resection of bone high-grade malignant tumors in children-about eleven cases.
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Smida M, Ammar A, Fedhila F, Douira W, and Sassi S
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- 2023
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21. Periosteal preservation: a new technique in resection of bone high-grade malignant tumors in children-about eleven cases.
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Smida M, Ammar A, Fedhila F, Douira W, and Sassi S
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- Bone Transplantation methods, Child, Humans, Humerus pathology, Humerus surgery, Polymethyl Methacrylate, Retrospective Studies, Treatment Outcome, Bone Neoplasms pathology, Osteosarcoma pathology, Osteosarcoma surgery
- Abstract
Objective: The purpose of this study was to describe a surgical technique of bone resection with periosteal preservation and reconstruction in patients with high-grade bone malignant tumors and to determine its effect on local recurrences, and time and quality of bone union in bone autografting reconstruction., Patients and Methods: We retrospectively reviewed 11 cases of high-grade malignant bone tumors in children aged 4 to 16 years, who were treated with chemotherapy and tumor resection while preserving partially the adjacent periosteum. Tumors were located in the lower limb in eight cases; three tumors were in the humerus. The mean length of the bone defect after resection was 15.8 cm (range, 6-34.5 cm). Reconstruction was provided by non-vascularized autograft in eight cases (lower limb) and polymethyl methacrylate spacer in three cases (upper limb). Patients were followed up for a mean of 71 months., Results: At the last follow-up, no patients had local recurrence. Three patients were dead because of metastasis. Bone union was good in time and quality in all children who had bone autografting. In cases of PMMA reconstruction, there was periosteal bone formation around the spacer. According to the MSTS functional score, patients with lower limb localizations had a mean score of 27.75 points and patients with upper limb localizations had a score of 24/30., Conclusion: Preservation of the periosteum in bone resection for malignant tumors could be a good adjuvant alternative for bone reconstruction, without increasing the risk of local recurrence. However, patients must be carefully selected., (© 2022. The Author(s).)
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- 2022
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22. [Chemotherapy-induced febrile neutropenia in a Tunisian Department of Pediatric Oncology].
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Fedhila F, Ahmed SB, Jbebli E, Mezghani F, Haddad S, Rhayem S, and Khemiri M
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- Aminoglycosides therapeutic use, Anti-Bacterial Agents, Cephalosporins therapeutic use, Child, Child, Preschool, Humans, Prospective Studies, Antineoplastic Agents adverse effects, Chemotherapy-Induced Febrile Neutropenia complications, Chemotherapy-Induced Febrile Neutropenia drug therapy, Neoplasms drug therapy, Neoplasms pathology
- Abstract
Chemotherapy-induced neutropenia (FN) is the most common infectious complication in pediatric oncology. To our knowledge, no pediatric research has been published in Tunisia. The purpose of our study was to describe the features of FN among Tunisian children and to investigate factors correlated with FN. We conducted a prospective study of children with chemotherapy-induced FN at the Department of Pediatric Medicine A of the Tunis Children´s Hospital from July 2019 to December 2019. We recorded 50 episodes of FN in 32 patients whose mean age was 5.3 years (3 months-16 years). We included 26 patients with solid tumors (81%) and six patients with hemopathies (18.7%). The mean time between last treatment and fever onset was 10.67 days. Bacteriological investigation was contributory in 18% of cases and mainly showed gram positive cocci. Therapeutic protocol including 1
st line empirical antibiotic therapy (3rd generation cephalosporin with aminoglycoside) was effective in 62% of cases. Mortality rate of patients with FN was 2%. The statistical study did not reveal any factor of correlation with late-onset neutropenia. In conclusion, our results are consistent with literature data on bacteriological documentation and mortality. Our 1st line treatment option based on 3rd generation cephalosporin associated with aminoglycoside was effective in 2/3 of the cases. In the future, oral antibiotics may be considered in patients at low risk for infection., Competing Interests: Les auteurs ne déclarent aucun conflit d´intérêts., (Copyright: Faten Fedhila et al.)- Published
- 2022
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23. The development of an international childhood cancer hospital register database in 13 African countries. A project of the French African Pediatric Oncology Group (GFAOP).
- Author
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Mallon B, Kaboré R, Couitchere L, Akonde FB, Lukamba R, Dackono TA, Narison MLR, Khattab M, Pondy A, Fedhila Ben Ayed F, Budiongo A, Guedenon K, Oberlin O, and Patte C
- Subjects
- Cancer Care Facilities, Child, Female, Hospitals, Humans, Male, Medical Oncology, Kidney Neoplasms, Neoplasms epidemiology, Neoplasms therapy, Wilms Tumor pathology
- Abstract
Background and Aim: The establishment of an international hospital-based register (HBR) for the French African Pediatric Oncology Group (GFAOP) was a necessary step in the group's clinical research program. With help from the Sanofi Espoir Foundation's "My Child Matters" program, the GFAOP resolved to develop an international HBR network to collect quality data on children attending the Pediatric Oncology Units (POUs)., Methods: All children entering POUs from January 2016 to December 2018 were registered using an online questionnaire. Data collection included information on diagnosis, disease stage, demographics, socioeconomic status, and outcome. An intensive training program was developed to improve both data quality and quantity., Results: Among the 3348 children registered, 3230 had a suspected cancer, 681 were not confirmed. A diagnosis was confirmed on radiological, clinical, or histological examination for 2549 children including Burkitt lymphoma (516: 20%)-the most frequent diagnosis, Wilms' tumor (459: 18%), retinoblastoma (357: 14%), and acute lymphoblastic leukemia (345: 13%). Of these, 2187 children were treated. Early deaths, abandonment, economic difficulties, and lack of equipment were some of the reasons offered to explain the numbers of undiagnosed and untreated children. Vital status is known for 1994 children: 1187 died and 807 were alive, 551 of these with a follow-up > 12 months., Conclusion: This work has provided reliable data on children attending the POUs, especially clarifying reasons and occasions for care rupture. The data will help to identify material, human resources, and staff training needs, to evaluate progress, and to encourage consideration of pediatric cancer in national cancer plans., (© 2021 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.)
- Published
- 2022
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24. Case Report: FOXP3 Mutation in a Patient Presenting With ALPS.
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Rais A, Mekki N, Fedhila F, Alosaimi MF, Ben Khaled M, Zameli A, Agrebi N, Sellami MK, Geha R, Ben-Mustapha I, and Barbouche MR
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- Autoimmune Lymphoproliferative Syndrome diagnosis, Autoimmune Lymphoproliferative Syndrome immunology, Child, Humans, Male, Mutation, Autoimmune Lymphoproliferative Syndrome genetics, Forkhead Transcription Factors genetics
- Abstract
ALPS and IPEX are two well-characterized inborn errors of immunity with immune dysregulation, considered as two master models of monogenic auto-immune diseases. Thus, with autoimmunity as their primary clinical manifestation, these two entities may show clinical overlap. Traditionally, immunological biomarkers are used to establish an accurate differential diagnosis. Herein, we describe a patient who presented with clinical features and biomarkers fulfilling the diagnostic criteria of ALPS. Severe apoptotic defect was also shown in the patient's cell lines and PHA-activated peripheral blood lymphocytes. Sanger sequencing of the FAS gene did not reveal any causal mutation. NGS screening revealed a novel deleterious variant located in the N terminal repressor domain of FOXP3 but no mutations in the FAS pathway-related genes. TEMRA cells (terminally differentiated effector memory cells re-expressing CD45RA) and PD1 expression were increased arguing in favor of T-cell exhaustion, which could be induced by unrestrained activation of T effector cells because of Treg deficiency. Moreover, defective FOXP3 observed in the patient could intrinsically induce increased proliferation and resistance to apoptosis in T effector cells. This observation expands the spectrum of FOXP3 deficiency and underscores the role of NGS in detecting mutations that induce overlapping phenotypes among inborn errors of immunity with immune dysregulation. In addition, these findings suggest a potential link between FOXP3 and FAS pathways., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Rais, Mekki, Fedhila, Alosaimi, Ben Khaled, Zameli, Agrebi, Sellami, Geha, Ben-Mustapha and Barbouche.)
- Published
- 2021
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25. Scurvy still exists in children: A case report.
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Ben Ahmed S, Mezghani F, Rhayem S, Fedhila F, and Hadded S
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- Ascorbic Acid therapeutic use, Child, Child, Preschool, Humans, Male, Radiography, Arthritis, Autistic Disorder, Scurvy complications, Scurvy diagnosis
- Abstract
Scurvy is one of the oldest diseases known to mankind. Although rare lately, the clinical suspicion arises in front of a precarious situation or deficient nutrition and food restriction secondary to a psychiatric condition, even in patients with non-specific complaints. We report the observation of a 6 -year- old boy, followed for autism since the age of 3 years and who was admitted for limping, hemorrhagic syndrome, arthritis and weakness. The diagnosis of child abuse was initially suspected but clinical and radiological abnormalities seen were characteristic of scurvy. Vitamin C level was undetectable. The child had an unbalanced diet.A favorable outcome was rapidly obtained following supplementation. Scurvy is rare, but it should be mentioned among children with psychiatric disorders, presenting with musculoskeletal manifestations or hemorrhagic syndrome. It is essential to prevent it by systematic dietary supplementation of vitamin C in children with eating difficulties.
- Published
- 2021
26. Pediatric Noncerebral Thromboembolism: Etiological Assessment and Outcome.
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Mezghani F, Kazdaghli K, Fedhila F, Rhayem S, Jbebli E, Hadded S, Douira W, Toumi N, and Khemiri M
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- Adolescent, Age of Onset, Anticoagulants therapeutic use, Central Venous Catheters adverse effects, Central Venous Catheters statistics & numerical data, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Infant, Infant, Newborn, Male, Neoplasms complications, Neoplasms epidemiology, Neoplasms therapy, Patient Admission statistics & numerical data, Prognosis, Retrospective Studies, Thromboembolism epidemiology, Thromboembolism therapy, Thromboembolism diagnosis, Thromboembolism etiology
- Abstract
Objective: To report clinical presentation and etiologic investigation findings during pediatric noncerebral thromboembolism., Methods: Retrospective study of cases of vascular non cerebral thromboses admitted in Medicine infantile A Department of the Children's Hospital of Tunis over 08 years., Results: We confirmed 14 cases of non cerebral vascular thromboses. So that these accidents constitute 0,26 ‰ of the overall etiologies of hospitalizations in the Department. The mean age of our patients was 56±41 months [25 days-12 1/2 years]. The sex ratio was 1.8. The vascular incident was venous in 2/3 of cases. The clinical presentation was mainly painful swelling in four cases, abrupt dyspnea and hematemesis in three cases each and the incident was locally asymptomatic in four cases. Thromboses locations included deep vein thrombosis of limbs (n=6), vena cava thrombosis (n=1), portal thrombosis (n=4) and pulmonary embolism (n=3). The promoting factors identified were: tumors in seven cases, thrombophilias and catheterization in four cases each, trauma, surgery and Behçet disease in one case each. Eleven patients received anticoagulant treatment including unfractioned heparin in three cases and low molecular weight heparin in the other cases. No one died while four patients developed sequelae., Conclusion: Vascular thromboses are rare in children. They are mostly venous and diagnosed in ill children especially those having central venous catheters. Outcome of pediatric thromboembolism depends on efficient anticoagulation therapy which is well tolerated by children.
- Published
- 2019
27. Autoimmune lymphoproliferative syndrome caused by homozygous FAS mutations with normal or residual protein expression.
- Author
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Agrebi N, Sfaihi Ben-Mansour L, Medhaffar M, Hadiji S, Fedhila F, Ben-Ali M, Mekki N, Hachicha M, Barsaoui S, Barbouche MR, and Ben-Mustapha I
- Subjects
- Autoimmune Lymphoproliferative Syndrome diagnosis, Humans, Immunophenotyping, Lymphocyte Count, Pedigree, T-Lymphocyte Subsets immunology, T-Lymphocyte Subsets metabolism, Autoimmune Lymphoproliferative Syndrome etiology, Autoimmune Lymphoproliferative Syndrome metabolism, Autoimmunity genetics, Genetic Predisposition to Disease, Homozygote, Mutation, fas Receptor genetics, fas Receptor metabolism
- Published
- 2017
- Full Text
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28. Soft Tissue Myoepithelial Carcinoma in a Child: Case Report.
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Fedhila Ben Ayed F, Douira Khomsi W, Rhayem S, Doghri R, Khemiri M, and Barsaoui S
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- Antineoplastic Agents therapeutic use, Disease Progression, Humans, Infant, Leg pathology, Male, Myoepithelioma drug therapy, Neoplasm Metastasis, Neoplasm Recurrence, Local, Soft Tissue Neoplasms drug therapy, Myoepithelioma pathology, Soft Tissue Neoplasms pathology
- Abstract
Background: Myoepithelial carcinoma was only recently recognized to occur primarily in soft tissue. Only a small number has been reported in children., Observation: We report a rare case of myoepithelial carcinoma of the leg in a 4-month-old boy with a good response to chemotherapy initially. However, he presented secondarily during chemotherapy a local and metastatic progression., Conclusions: The rarity of the tumor and unusual age of discovery have prompted us to report this case. Our case suggests that this disease can have an aggressive behavior. This is why we advise a rapid and correct diagnosis followed by an aggressive treatment.
- Published
- 2016
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29. Prognostic factors in children with extracranial malignant germ cell tumors: a monocentric pediatric Tunisian study.
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Fedhila F, Rhayem S, Hafsi H, Douira W, Doghri R, Khemiri M, Mrad K, Bellagha I, Zouari B, and Barsaoui S
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- Adolescent, Child, Child, Preschool, Disease-Free Survival, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Kaplan-Meier Estimate, Male, Multivariate Analysis, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasms, Germ Cell and Embryonal epidemiology, Neoplasms, Germ Cell and Embryonal surgery, Prognosis, Retrospective Studies, Survival Rate, Tunisia epidemiology, Neoplasms, Germ Cell and Embryonal pathology, Salvage Therapy methods
- Abstract
Background Extracranial Germ cell tumors (GCT) are a rare and a heterogeneous group of pediatric cancers but highly curable. Aim We aimed to review management, outcome and prognostic factors that influence overall survival (OS) in a pediatric Tunisian oncologic unit. Methods We retrospectively evaluated between January 1998 and December 2012, 33 patients affected by extracranial germ cell tumors and treated according to TGM95 protocol established by the SFOPin a pediatric Tunisian oncologic unit. Results Patients had a mean age of 57 months (ranges: 1 day-13 years). There were 19 girls and 14 boys. Primary sites included 12 sacrococcygeal, 11 ovarian, 6 testicular, 3retro peritoneal and 1 mediastinal site. After a mean follow up of 26.1 months (ranges: 0-96 months), OSat 2 years and 5 years were respectively 82% and 75%. Event-free survival were respectively 79% at 2 years and 74% at 5 years. Various prognostic factors have been studied according to Kaplan-Meier. Univariate analyses identified significant factors which influence strongly OS: the stage (p=0.04), the completeness of surgery (p<0.001) and the relapse (p = 0, 0001). A multivariate study showed that only the quality of resection and the clinical stage remained strong significant prognostic factors (p=0,021) for 5-year OS. Conclusion Disease stage, completeness of surgery and relapse have been established as the most powerful prognostic parameter in our analysis. The improvement of survival of patients affected by extracranial germ cell tumors in Tunisia is a real achievement mainly due to the success of salvage treatments.
- Published
- 2016
30. Burkitt lymphoma in a child with Bloom syndrome.
- Author
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Fedhila-Ben Ayed F, Douira-Khomsi W, Rhayem S, Jelassi M, Zribi H, Chaabouni M, Khemiri M, Bellagha I, and Barsaoui S
- Subjects
- Burkitt Lymphoma diagnosis, Burkitt Lymphoma therapy, Child, Preschool, Fatal Outcome, Humans, Male, Bloom Syndrome complications, Burkitt Lymphoma etiology
- Abstract
Background: Bloom syndrome is a rare disease characterized by chromosomal instability and increased risk of developing lymphoma., Observation: We report on a case of Bloom syndrome in a 5-year-old boy with Burkitt lymphoma. The diagnosis was suspected by growth retardation, repeated respiratory infections, facial telangiectasia, and a low immunoglobulin level, then confirmed cytogenetically by sister chromatid exchanges. Chemotherapy was poorly tolerated, which required reducing the doses. Unfortunately, it was not sufficient to control the neoplasm and the patient died 14 months after diagnosis., Conclusions: Cancers in Bloom syndrome are a challenge since the potentially life-threatening side effects of the chemotherapy may require modifications in standard treatment such as dose reduction, which can compromise the tumor prognosis., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
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- 2016
- Full Text
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31. [Secondary TFE3-associated renal cell carcinoma in a child treated for Ewing sarcoma].
- Author
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Fedhila Ben Ayed F, Rhayem S, Doghri R, Ben Hassine L, Khemiri M, Mrad K, Bellagha I, and Barsaoui S
- Subjects
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors genetics, Child, Female, Humans, Translocation, Genetic, Bone Neoplasms therapy, Carcinoma, Renal Cell diagnosis, Carcinoma, Renal Cell genetics, Carcinoma, Renal Cell therapy, Kidney Neoplasms diagnosis, Kidney Neoplasms genetics, Kidney Neoplasms therapy, Neoplasms, Second Primary diagnosis, Neoplasms, Second Primary genetics, Neoplasms, Second Primary therapy, Sarcoma, Ewing therapy
- Abstract
Renal cell carcinoma is a rare pediatric malignant tumor of the kidney. Unlike Wilms tumor, the efficacy of chemotherapy and radiation therapy in pediatric renal cell carcinoma remains uncertain. Surgery is the best treatment and prognosis is favorable when the tumor is localized and completely eradicated. We report an exceptional observation in a 7-year-old girl with renal cell carcinoma who had been treated 20 months previously for Ewing sarcoma with chemotherapy and radiotherapy. The renal tumor was revealed by abdominal pain without hematuria. She underwent a radical nephrectomy, and histopathology concluded in renal carcinoma associated with translocation Xp 11.2 grade 3 of Furhrman pT3a N1. No adjuvant therapy was given. After 3 years of follow-up, there is no evidence of local or metastatic recurrence. This observation is significant given the very young age of this patient, the occurrence after Ewing sarcoma with a short disease-free interval. It seems that translocation renal cell carcinoma is associated with previous exposure to chemotherapy, particularly topoisomerase II inhibitors or alkylating agents., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
32. Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents.
- Author
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Bodo S, Colas C, Buhard O, Collura A, Tinat J, Lavoine N, Guilloux A, Chalastanis A, Lafitte P, Coulet F, Buisine MP, Ilencikova D, Ruiz-Ponte C, Kinzel M, Grandjouan S, Brems H, Lejeune S, Blanché H, Wang Q, Caron O, Cabaret O, Svrcek M, Vidaud D, Parfait B, Verloes A, Knappe UJ, Soubrier F, Mortemousque I, Leis A, Auclair-Perrossier J, Frébourg T, Fléjou JF, Entz-Werle N, Leclerc J, Malka D, Cohen-Haguenauer O, Goldberg Y, Gerdes AM, Fedhila F, Mathieu-Dramard M, Hamelin R, Wafaa B, Gauthier-Villars M, Bourdeaut F, Sheridan E, Vasen H, Brugières L, Wimmer K, Muleris M, and Duval A
- Subjects
- Adaptor Proteins, Signal Transducing genetics, Adenosine Triphosphatases genetics, Adult, Brain Neoplasms drug therapy, Brain Neoplasms genetics, Brain Neoplasms metabolism, Brain Neoplasms pathology, Caco-2 Cells, Case-Control Studies, Colorectal Neoplasms drug therapy, Colorectal Neoplasms genetics, Colorectal Neoplasms metabolism, Colorectal Neoplasms pathology, Colorectal Neoplasms, Hereditary Nonpolyposis drug therapy, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Colorectal Neoplasms, Hereditary Nonpolyposis metabolism, Colorectal Neoplasms, Hereditary Nonpolyposis pathology, DNA Mutational Analysis, DNA Repair Enzymes genetics, DNA-Binding Proteins genetics, Female, Genetic Predisposition to Disease, HCT116 Cells, Heredity, Humans, Lymphocytes metabolism, Male, Methylation, Mismatch Repair Endonuclease PMS2, Multiplex Polymerase Chain Reaction, MutL Protein Homolog 1, MutS Homolog 2 Protein genetics, Neoplastic Syndromes, Hereditary drug therapy, Neoplastic Syndromes, Hereditary genetics, Neoplastic Syndromes, Hereditary metabolism, Neoplastic Syndromes, Hereditary pathology, Nuclear Proteins genetics, Phenotype, Predictive Value of Tests, Reproducibility of Results, Transfection, Young Adult, Antineoplastic Agents, Alkylating therapeutic use, Biomarkers, Tumor genetics, Brain Neoplasms diagnosis, Colorectal Neoplasms diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, Drug Resistance, Neoplasm, Genetic Testing methods, Germ-Line Mutation, Lymphocytes drug effects, Microsatellite Instability, Neoplastic Syndromes, Hereditary diagnosis
- Abstract
Background & Aims: Patients with bi-allelic germline mutations in mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2) develop a rare but severe variant of Lynch syndrome called constitutional MMR deficiency (CMMRD). This syndrome is characterized by early-onset colorectal cancers, lymphomas or leukemias, and brain tumors. There is no satisfactory method for diagnosis of CMMRD because screens for mutations in MMR genes are noninformative for 30% of patients. MMR-deficient cancer cells are resistant to genotoxic agents and have microsatellite instability (MSI), due to accumulation of errors in repetitive DNA sequences. We investigated whether these features could be used to identify patients with CMMRD., Methods: We examined MSI by PCR analysis and tolerance to methylating or thiopurine agents (functional characteristics of MMR-deficient tumor cells) in lymphoblastoid cells (LCs) from 3 patients with CMMRD and 5 individuals with MMR-proficient LCs (controls). Using these assays, we defined experimental parameters that allowed discrimination of a series of 14 patients with CMMRD from 52 controls (training set). We then used the same parameters to assess 23 patients with clinical but not genetic features of CMMRD., Results: In the training set, we identified parameters, based on MSI and LC tolerance to methylation, that detected patients with CMMRD vs controls with 100% sensitivity and 100% specificity. Among 23 patients suspected of having CMMRD, 6 had MSI and LC tolerance to methylation (CMMRD highly probable), 15 had neither MSI nor LC tolerance to methylation (unlikely to have CMMRD), and 2 were considered doubtful for CMMRD based on having only 1 of the 2 features., Conclusion: The presence of MSI and tolerance to methylation in LCs identified patients with CMMRD with 100% sensitivity and specificity. These features could be used in diagnosis of patients., (Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
33. [High T2 signal intensity of the brainstem in a child undergoing chemotherapy].
- Author
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Douira-Khomsi W, Mahmoud M, Fedhila F, Ben Hassine L, Lahmar L, Barsaoui S, and Bellagha I
- Subjects
- Child, Preschool, Confusion etiology, Contrast Media, Dyspnea etiology, Gadolinium, Humans, Muscle Hypotonia etiology, Predictive Value of Tests, Sensitivity and Specificity, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hyponatremia complications, Magnetic Resonance Imaging methods, Myelinolysis, Central Pontine etiology, Myelinolysis, Central Pontine pathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
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- 2013
- Full Text
- View/download PDF
34. [Centropontine myelinosis in a child undergoing chemotherapy].
- Author
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Douira-Khomsi W, Mahmoud M, Fedhila F, Ben Hassine L, Lahmar L, Barsaoui S, and Bellagha I
- Subjects
- Child, Preschool, Confusion etiology, Contrast Media, Gadolinium, Humans, Muscle Hypotonia etiology, Predictive Value of Tests, Sensitivity and Specificity, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hyponatremia complications, Magnetic Resonance Imaging, Myelinolysis, Central Pontine etiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
- Published
- 2013
- Full Text
- View/download PDF
35. [Value of procalcitonin measurement in maternal fetal infection].
- Author
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Bouyahia O, Ncibi N, Fedhila F, Amdouni N, Ben Aissa J, Messoud T, Boukthir S, and Sammoud El Gharbi A
- Subjects
- Bacterial Infections transmission, C-Reactive Protein analysis, Calcitonin Gene-Related Peptide, Female, Humans, Infant, Newborn, Male, Predictive Value of Tests, Pregnancy, Prospective Studies, Sensitivity and Specificity, Calcitonin blood, Infant, Newborn, Diseases diagnosis, Infectious Disease Transmission, Vertical, Pregnancy Complications, Infectious blood, Protein Precursors blood
- Abstract
Background: Materno foetal infection (MFI) remains one of the major causes of neonatal morbidity and mortality. Early detection of neonatal sepsis can be difficult, because the first signs of the disease may be unspecific and similar to symptoms of other non-infectious processes., Aim: We aimed to investigate the role of procalcitonin (PCT) in the diagnosis of fetal infection (MFI), and to compare it with those of the C-reactive protein (CRP)., Methods: We have conducted a prospective study during 20 months: which concerned 25 newborns suspected of MFI and admitted before 12 hours of life. All newborn had anamnestic and/or physical signs of possible infection. MFI was confirmed in newborns with positive bacterial analysis. CRP and PCT were determined in the sera at H12, H24, H36 and H48. Newborns were divided into: patients with recognized MFI (group 1), patients with possible MFI (group2) and non infected newborns (group 3):, Results: The specificity of PCT was 80% versus 27% for the CRP. Negative predictive value of PCT was 85% versus 66% for the CRP. The mean values, at H12, H24, H36 and H48, of PCT for newborn who had MFI were statistically grater than those for no infused group (p<0.05). No statistical difference was observed concerning CRP values., Conclusions: PCT may a useful tool in early diagnosing of MFI; it has better specificity and negative predictive value than CRP.
- Published
- 2009
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