63 results on '"F. DELFINO"'
Search Results
2. Current and Emerging Uses of Statins in Clinical Therapeutics: A Review
- Author
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Anthony P. Schwab, Meghan F. Johnson, Hollie I. Swanson, Spencer F. Delfino, Joshua T. Olinger, Jonathan Tokonjay Davies, Chad E. Feinberg, and Veronica L. Nappi
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Drug ,medicine.medical_specialty ,Evidence-based practice ,Statin ,autoimmune and chronic inflammatory diseases ,medicine.drug_class ,media_common.quotation_subject ,Pharmacy ,Disease ,Review ,030204 cardiovascular system & hematology ,Biochemistry ,statins ,03 medical and health sciences ,0302 clinical medicine ,medicine ,cancer ,cardiovascular diseases ,Intensive care medicine ,Adverse effect ,media_common ,low-density lipoprotein cholesterol ,business.industry ,Cancer ,nutritional and metabolic diseases ,atherosclerotic cardiovascular disease ,medicine.disease ,030220 oncology & carcinogenesis ,Informatics ,adverse effects ,lipids (amino acids, peptides, and proteins) ,business ,Biomedical engineering - Abstract
Statins, a class of cholesterol-lowering medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, are commonly administered to treat atherosclerotic cardiovascular disease. Statin use may expand considerably given its potential for treating an array of cholesterol-independent diseases. However, the lack of conclusive evidence supporting these emerging therapeutic uses of statins brings to the fore a number of unanswered questions including uncertainties regarding patient-to-patient variability in response to statins, the most appropriate statin to be used for the desired effect, and the efficacy of statins in treating cholesterol-independent diseases. In this review, the adverse effects, costs, and drug–drug and drug–food interactions associated with statin use are presented. Furthermore, we discuss the pleiotropic effects associated with statins with regard to the onset and progression of autoimmune and inflammatory diseases, cancer, neurodegenerative disorders, strokes, bacterial infections, and human immunodeficiency virus. Understanding these issues will improve the prognosis of patients who are administered statins and potentially expand our ability to treat a wide variety of diseases.
- Published
- 2016
3. Patient Perceptions of Cholesterol Medications
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Spencer F. Delfino, Stephanie Rose, Anthony P. Schwab, Meghan F. Johnson, Jonathan Tokonjay Davies, Kevin Real, Joshua T. Olinger, Veronica L. Nappi, and Chad E. Feinberg
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medicine.medical_specialty ,chemistry.chemical_compound ,Patient perceptions ,chemistry ,business.industry ,Cholesterol ,Internal medicine ,Genetics ,Medicine ,business ,Molecular Biology ,Biochemistry ,Biotechnology - Published
- 2018
4. Identification and management of an electrical storage system for application in photovoltaic installations
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F. Delfino, G. Ferro, R. Minciardi, M. Robba, and M. Rossi
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Engineering ,Optimization problem ,model predictive control ,020209 energy ,microgrids ,02 engineering and technology ,Storage model ,Industrial and Manufacturing Engineering ,Real-time Control System ,Artificial Intelligence ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,electrical storage ,identification ,optimization ,Computer Science Applications1707 Computer Vision and Pattern Recognition ,Control and Systems Engineering ,business.industry ,Photovoltaic system ,Control engineering ,Grid ,Model predictive control ,Computer data storage ,Microgrid ,business - Abstract
The aim of this paper is to propose a MPC (Model Predictive Control)-based hierarchical architecture for microgrids characterized by photovoltaics and storage systems. The first part of the work is focused on the storage model's identification during the charge and discharge phases with the aim of defining appropriate constraints to be inserted in the decision model. In the higher level, an optimization problem is developed and solved under a MPC scheme. The lower level, implemented on a PLC, receives references from the higher level and applies simple heuristics rules for real time control, on the basis of weather forecasts and data measured in real time. The developed algorithms have been applied to a real case study: a portion of the Savona Campus (University of Genoa) polygeneration microgrid that includes a photovoltaic field, an electric storage system, a load, and a connection with the electric grid.
- Published
- 2017
5. ALDOSTERONE INDUCES CYP11B2 GENE EXPRESSION VIA GPER-1 ACTIVATION IN HUMAN ADRENOCORTICAL CELL (HAC15) AND STRIPS FROM ALDOSTERONE PRODUCING ADENOMA
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G.P. Rossi, Maria Piazza, Brasilina Caroccia, T.M. Seccia, and F. Delfino
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Adrenocortical cell ,medicine.medical_specialty ,Aldosterone ,Physiology ,business.industry ,Aldosterone producing adenoma ,Cyp11b2 gene ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,Internal Medicine ,medicine ,Cardiology and Cardiovascular Medicine ,business ,GPER - Published
- 2018
6. GRID-Based Power Measurement in Digital Wireless Communication Systems
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F. Delfino, Luigi Battaglia, Leopoldo Angrisani, Angrisani, Leopoldo, Battaglia, L, and Delfino, F.
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Computer science ,business.industry ,Context (language use) ,Digital radio ,computer.software_genre ,Grid ,Software ,Computer engineering ,Grid computing ,Electronic engineering ,Key (cryptography) ,Wireless ,Electrical and Electronic Engineering ,business ,Instrumentation ,computer - Abstract
The combined use of multitaper estimation and wavelet thresholding has proved to be a very powerful digital- signal-processing algorithm in achieving the true power spectrum of signals that are peculiar to digital wireless communication systems and in ultimately carrying out accurate and repeatable power measurements. Nevertheless, the induced computational burden is too heavy. This paper mainly shows that GRID, which is currently one of the key technologies in deploying global-scale computing infrastructures, can make the aforementioned algorithm enforceable in a real-time context. A GRID computing-based approach for power measurement in digital wireless communication systems is proposed, which allows high levels of accuracy and repeatability in a significantly reduced measurement time. After a concise outline of the measurement algorithm, all of the adopted hardware and software strategies are described in detail. Major results concerning performance assessment and actual measurements are also given and discussed.
- Published
- 2007
7. List of contributors
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A. Allais, K. Allweins, F.A. Amoroso, R. Bago, Stephanie Bätjer, Antonella Battaglini, J.-L. Bessède, S. Bracco, S. Brisset, C.E. Bruzek, M. Campos, F. Delfino, D. Dickson, C. Espanet, C.M. Feng, R.C. Furtado, G. Ghatikar, F. Gillon, M. Hassanzadeh, C. Jagu, S. Kiliccote, N. Lallouet, J. Liang, F. Maltini, F.P.G. Márquez, E. Marzahn, R. Metz, R. Minder, P. Monjean, S. Mouty, F. Pampararo, J.M.P. Pérez, M.A. Piette, B. Robyns, and Wenlu Wang
- Published
- 2015
8. A field based inverse algorithm for the identification of the lightning return stroke
- Author
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A. ANDREOTTI, F. DELFINO F, U. DE MARTINIS, R. PROCOPIO, VEROLINO, LUIGI, Andreotti, Amedeo, F., Delfino, U., DE MARTINIS, R., Procopio, L., Verolino, A., Andreotti, F., DELFINO F, and Verolino, Luigi
- Published
- 2000
9. A new FEM approach for field and torque simulation of electrostatic microactuators
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F. Delfino and M. Rossi
- Subjects
Coupling ,Electromagnetic field ,Engineering ,Rotor (electric) ,business.industry ,Mechanical Engineering ,Finite element method ,law.invention ,Electrostatic motor ,law ,Control theory ,Electrostatic generator ,Electronic engineering ,Torque ,Electrical and Electronic Engineering ,Perfect conductor ,business - Abstract
A novel finite-element method (FEM) floating-conductor formulation for the numerical electromagnetic analysis of electrostatic microactuators is presented and discussed in this paper. It is based on the assumption that the moving part of the microdevice can be modeled as a perfect conductor and leads to a considerable reduction of the mesh size, as the region occupied by the moving part does not need to be discretized at all. It is also shown that the developed formulation can be easily coupled with the well-known method of equivalent charges for the computation of the driving torque acting upon the rotor of the microdevice. This coupling is performed directly in terms of variables involved in the solution process of the final algebraic system and it allows acquiring torque information without any postprocessing operation. The proposed approach has been applied to the analysis of an electrostatic micromotor with radial field. When compared to simulations obtained with a commercial FEM electromagnetic code using a classical high-permittivity formulation, this method proves to be accurate and exhibits an overall reduction of preprocessing, processing and postprocessing time.
- Published
- 2002
10. Lightning return stroke current radiation in presence of a conducting ground: Validity assessment of simplified approaches
- Author
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F. Delfino, R. Procopio, M. Rossi, F. Rachidi, NUCCI, CARLO ALBERTO, F. Delfino, R. Procopio, M. Rossi, F. Rachidi, and C. A. Nucci
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SOMMERFELD INTEGRALS ,LIGHTNING ,LIGHTNING ELECTROMAGNETIC FIELD CALCULATION - Abstract
In this paper, the developed formulation, which we shall call the ‘‘reference’’ one, is used to assess the validity of the most popular simplified approach for the calculation of the lightning electromagnetic field over a conducting earth, namely, the Cooray-Rubinstein (CR) approximation. This formula provides a simple method to evaluate the radial component of the electric field which is the component most affected by the finite ground conductivity and which plays an important role within the Agrawal et al. (1980) field-to-transmission line-coupling model. Several configurations are examined, with different values for the ground conductivity and different field observation points. A thorough analysis of all the simulated field components is carried out and comparisons are also made with the ‘‘ideal’’ field, namely, the field that would be present under the assumption of perfectly conducting ground. It is shown that for channel base current typical of subsequent strokes and for very low conductivities, the CR formula exhibits some deviations from the reference one but it still represents a conservative estimation of the radial field component, since it behaves as un upper bound for the exact curve. The developed algorithm is characterized by fast performances in terms of CPU time, lending itself to be used for several applications, including a coupling code for lightning induced overvoltages calculations.
- Published
- 2008
11. GRID-based approach for power measurement in digital wireless communication systems
- Author
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Luigi Battaglia, F. Delfino, Leopoldo Angrisani, Angrisani, Leopoldo, L., Battaglia, and F., Delfino
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Signal processing ,business.industry ,Computer science ,Wavelet transform ,Spectral density ,Context (language use) ,computer.software_genre ,Power (physics) ,Software ,Grid computing ,Multitaper ,Electronic engineering ,business ,computer - Abstract
The combined use of multitaper estimation and wavelet thresholding has proved very attractive for achieving the true power spectrum of signals peculiar to digital wireless communication systems, and thus carrying out accurate and repeatable power measurements. Nevertheless, the computational burden induced is too heavy. The paper presents a GRID computing based approach to make the aforementioned digital signal-processing algorithms enforceable in a real-time context. All adopted software strategies are explained in detail along with major results concerning performance assessment and actual measurements.
- Published
- 2006
12. Stage-Specific Nuclear Expression of NF- B in Mammalian Testis
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F. Delfino
- Subjects
Endocrinology ,General Medicine ,Molecular Biology - Published
- 1998
13. IMPIEGO DI UNA PIATTAFORMA GRID PER LA MISURAZIONE DI POTENZA NEI SISTEMI DI COMUNICAZIONE DIGITALE WIRELESS
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ANGRISANI, LEOPOLDO, L. BATTAGLIA, F. DELFINO, Angrisani, Leopoldo, L., Battaglia, and F., Delfino
- Published
- 2005
14. Lightning current identification over a conducting ground plane
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VEROLINO, LUIGI, F. DELFINO, R. PROCOPIO, M. ROSSI, Delfino, F., Procopio, R., Rossi, M., Verolino, Luigi, F., Delfino, R., Procopio, and M., Rossi
- Subjects
Geochemistry and Petrology ,Geophysics ,Atmospheric Science ,Computers in Earth Sciences ,Computer Networks and Communications ,Instrumentation - Published
- 2003
15. Evaluation of antifungal activity of extracts of Punica granatum L. on Malassezia pachydermatis
- Author
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F Delfino, BM Damiani, LS Matsumoto, RM Silva, and EC Mello-Peixoto
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Pharmacology ,Antifungal ,medicine.drug_class ,Organic Chemistry ,Pharmaceutical Science ,Biology ,biology.organism_classification ,Malassezia pachydermatis ,Analytical Chemistry ,Microbiology ,Complementary and alternative medicine ,Punica ,Drug Discovery ,medicine ,Molecular Medicine - Published
- 2013
16. Lightning current identification in presence of a lossy ground
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F. DELFINO, R. PROCOPIO, M. ROSSI, L. VEROLINO, ANDREOTTI, AMEDEO, A., Andreotti, F., Delfino, R., Procopio, M., Rossi, Verolino, Luigi, Andreotti, Amedeo, and L., Verolino
- Published
- 2002
17. UNARCHITETTURA SOFTWARE GENERALE PER LA TRASFORMAZIONE DI FLUSSI DIGITALI
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FADINI, BRUNO, IANNELLO, GIULIO, L. VOLLERO, F. DELFINO, Fadini, Bruno, Iannello, Giulio, L., Vollero, and F., Delfino
- Published
- 2002
18. Lightning current identification in presence of a lossy round
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F. DELFINO, R. PROCOPIO, M. ROSSI, A. ANDREOTTI, VEROLINO, LUIGI, F., Delfino, R., Procopio, M., Rossi, A., Andreotti, and Verolino, Luigi
- Published
- 2002
19. THE CLUSTERS FILE SYSTEM: INTEGRATION OF HIGH PERFORMANCE COMMUNICATION AND I/O IN CLUSTERS
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IANNELLO, GIULIO, R. CRISTALDI, F. DELFINO, Iannello, Giulio, R., Cristaldi, and F., Delfino
- Published
- 2002
20. An identification procedure for lightming return strokes
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ANDREOTTI, AMEDEO, F. DELFINO, P. GIRDINIO, L. VEROLINO, Andreotti, Amedeo, F., Delfino, P., Girdinio, and L., Verolino
- Published
- 2001
21. Ricostruzione della corrente di ritorno associata a fulminazioni nuvola-terreno mediante misure di campo elettromagnetico
- Author
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ANDREOTTI, AMEDEO, F. Delfino, U. De Martinis, R. Procopio, L. Verolino, A., Andreotti, F., Delfino, U., DE MARTINIS, R., Procopio, Verolino, Luigi, Andreotti, Amedeo, U., De Martini, and L., Verolino
- Published
- 2001
22. A new method to identify return stroke characteristics
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ANDREOTTI, AMEDEO, U. DE MARTINIS, L. VEROLINO, F. DELFINO, P. GIRDINIO, DE MARTINIS, Umberto, Andreotti, A., Verolino, L., Delfino, F., Girdinio, P., A., Andreotti, U., DE MARTINIS, F., Delfino, P., Girdinio, Verolino, Luigi, Andreotti, Amedeo, and L., Verolino
- Published
- 2001
23. An inverse procedure for the reconstruction of the height-dependent attenuation function for lightning return strokes
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A. ANDREOTTI, U. DE MARTINIS, F. DELFINO, R. PROCOPIO, VEROLINO, LUIGI, Andreotti, Amedeo, U., DE MARTINIS, L., Verolino, F., Delfino, R., Procopio, A., Andreotti, and Verolino, Luigi
- Published
- 2000
24. Harry Potter and the quest for knowledge
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Caviglia F. & Delfino M.
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literature ,teaching methods ,models of schooling ,Harry Potter ,teacher education - Published
- 2009
25. Placental lesions in a case of DiGeorge sequence
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F Delfino, M. Gualco, M F Pantarotto, and Ezio Fulcheri
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Embryology ,Cord ,Placenta ,Umbilical Arteries ,DiGeorge syndrome ,DiGeorge Syndrome ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Sequence (medicine) ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Calcinosis ,General Medicine ,Anatomy ,medicine.disease ,Thrombosis ,Hypoplasia ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Amniocentesis ,Female ,business ,Calcification ,Artery - Abstract
This work describes some placental alterations found in a partial form of DiGeorge sequence, namely, hypoplasia of a cord artery with internal calcification of an extensive endoluminal thrombosis, and widespread calcification of microthrombi in the arteries of the second and third order villous branches. Hypoplasia of a cord artery is a relatively rare event, and is also associated with malformations of the gastroenteric and cardiovascular system, as sometimes described in the DiGeorge sequence. Interesting placental alterations are reported and their likely physiopathologic basis and pathogenic correlation discussed in order to give a better and more comprehensive picture of the DiGeorge sequence in which the correlated placental alterations are not sufficiently known.
- Published
- 2003
26. THE STATISTICAL ANALYSIS OF ACTIVE CONTROL EQUIVALENCE STUDIES
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Armando Garsd and Susana F. Delfino
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Applied mathematics ,Statistical analysis ,General Medicine ,Active control ,Equivalence (measure theory) ,Mathematics - Published
- 1997
27. A new method for the solution of convolution-type dual integral-equation systems occurring in engineering electromagnetics.
- Author
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F. Delfino, R. Procopio, and M. Rossi
- Abstract
Abstract A general method for the solution of dual integral-equation systems is discussed in the context of applications in engineering electromagnetics. The approach follows a formulation based on a Fourier-series expansion of the unknown function and a successive expansion in a Neumann series of the Fourier-series coefficients. It is characterized by better convergence properties than classical numerical techniques usually adopted to solve the same class of problems and low computational costs. The efficiency and the performance of the proposed method are illustrated using the example of a typical electrostatic problem: the evaluation of the charge distribution of a hollow conducting cylinder, starting from the knowledge of the potential on the surface. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
28. [Systemic lupus erythematosus: study of 48 patients with emphasis on renal involvement]
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M de L, Boas, E E, Nakayama, M F, Carvalho, J F, Delfino Filho, S L, Neiva, F, Habermann, R J, Franco, V A, Soares, and D B, de Almeida
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Adult ,Male ,Adolescent ,Middle Aged ,Kidney ,Prognosis ,Lupus Nephritis ,Creatinine ,Humans ,Lupus Erythematosus, Systemic ,Prednisone ,Female ,Child ,Cyclophosphamide ,Retrospective Studies - Published
- 1988
29. Diabetes in pregnancy. An epidemiologic study by Department of Obstetrics and Gynaecology of Sassari University from 1974 to 1983
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G, Piras, P L, Cherchi, F, Delfino, D, Caburlotto, L, Sanna, and V, Riggio
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Adult ,Adolescent ,Italy ,Pregnancy ,Infant Mortality ,Infant, Newborn ,Pregnancy in Diabetics ,Birth Weight ,Humans ,Female ,Middle Aged ,Fetal Death - Abstract
We examined 102 pregnancies in 59 diabetic women by Department of Gynaecology and Obstetrics of Sassari University from 1974 to 1983, we evaluated pregnancy and labor proceeding, perinative morbidity and mortality. Our issues show a perinative mortality high yet (14.8%), not always comparable to severity of maternal diabetes, that's mainly due to insufficient number of controls undertaken from patients for their por medical education. Recently diabetic pregnant women have getting used to routine controls of metabolic balance, pregnancy evolution and fetal well-being through biochemical and biophysic monitoring; that allows to obtain an improvement of perinative mortality.
- Published
- 1985
30. A MATHEMATICAL MODEL TO CONTROL A SIX STAND HOT STRIP FINISHING MILL
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F. Belgrano, G. Chighizola, F. Delfino, V. Giori, and V. Neglia
- Published
- 1980
31. Evaluation of the field coupling to a line of finite length - a comparison between the dual integral equation approach and the moment method
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Amedeo Andreotti, Luigi Verolino, Paola Girdinio, Renato Procopio, Federico Delfino, A., Andreotti, F., Delfino, P., Girdinio, R., Procopio, Verolino, Luigi, Andreotti, Amedeo, and L., Verolino
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Electromagnetic field ,Physics and Astronomy (miscellaneous) ,Field (physics) ,Mathematical analysis ,Linear system ,Transmission line modeling ,Fredholm integral equation ,Integral equation ,Electronic, Optical and Magnetic Materials ,Moment (mathematics) ,symbols.namesake ,Algebraic equation ,Line (geometry) ,symbols ,Electromagnetic compatibility ,Electrical and Electronic Engineering ,Mathematics - Abstract
In this paper, it is shown that the problem of the electromagnetic field coupling to a line of finite length can be put into "a standard form" of dual integral equations. A general method for solving such dual integral equations is presented and discussed. It basically consists of a transformation of the first kind Fredholm equation into a linear system of algebraic equations by means of a suitable Neumann expansion of the unknown function. This procedure, carried out in the frequency domain, has allowed evaluating the current induced on the line, which has also been computed with the classical method of moment in order to have a validation of the procedure itself.
- Published
- 2002
32. An identification procedure for lightning return strokes
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Federico Delfino, Paola Girdinio, Amedeo Andreotti, Luigi Verolino, Andreotti, A., Delfino, F., Girdinio, P., Verolino, Luigi, A., Andreotti, F., Delfino, and P., Giurdinio
- Subjects
Engineering ,Computer simulation ,business.industry ,Acoustics ,Condensed Matter Physics ,Lightning ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Exponential function ,Identification (information) ,Transmission line ,Electric field ,Electronic engineering ,Waveform ,Electrical and Electronic Engineering ,business ,Biotechnology ,Communication channel - Abstract
In this paper an inverse procedure for the identification and the reconstruction of the waveform of the lightning return stroke current is presented. It is based on the acquisition of the vertical component of the electric field radiated by the discharge channel at different locations on the ground and it does not require any information about the channel base current. The approach has been validated by means of the numerical simulation of the classical Transmission Line, Modified Transmission Line Linear and Modified Transmission Line Exponential engineering models, showing good accuracy in all cases.
- Published
- 2001
33. An algorithm for the exact evaluation of the underground lightning electromagnetic fields
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Federico Delfino, Farhad Rachidi, Mansueto Rossi, Renato Procopio, Ca. Nucci, F. Delfino, R. Procopio, F. Rachidi, and C.A. Nucci
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Electromagnetic field ,Engineering ,business.industry ,Computer Networks and Communications ,Computation ,Numerical analysis ,Modeling ,Condensed Matter Physics ,Integral equation ,Upper and lower bounds ,Atomic and Molecular Physics, and Optics ,Lightning ,Electromagnetic propagation in absorbing media ,Electrical and Electronic Engineering ,Exact solutions in general relativity ,Ground conductivity ,Improper integral ,LIGHTNING-INDUCED TRANSIENTS ,business ,Algorithm - Abstract
The number of power installations lying underground has been increasing in the last few years, and such devices are very sensitive to the effect of the lightning electromagnetic fields, due to the massive presence of power electronics. As a consequence, the scientific community has devoted much effort in the direction of a more accurate modeling of underground lightning fields and their coupling to cables. The exact expressions of the underground lightning fields have been derived by Sommerfeld decades ago. However, their numerical evaluation has always been a hard task because of the presence of slowly converging improper integrals. In the past, some approximate formulas have been derived, which have been included in field-to-transmission line coupling models to estimate the effect of lightning on buried cables. In this paper, an efficient algorithm for the evaluation of the Sommerfeld expression for underground fields is presented, and its mathematical features are discussed. The numerical treatment of the Sommerfeld integrals is based on a proper subdivision of the integration domain, the application of the Romberg technique, and the definition of a suitable upper bound for the error due to the integral truncation. The remarkable efficiency in terms of CPU time of the developed algorithm makes it possible to use it directly in field-to-buried cable coupling simulation codes. Finally, the developed algorithm is used to test the validity of the Cooray's simplified formula for the computation of underground horizontal electric field. It is shown that predictions of the Cooray's formula are in good agreement with exact solutions for large values of ground conductivity (0.01 S/m). However, for poor conductivities (0.001 S/m or so) Cooray's expression yields less satisfactory results, especially for the late time response.
- Published
- 2007
34. Comparison of different approaches for the evaluation of lightning-induced overvoltages in light-rail DC traction power systems
- Author
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Delfino, F., Procopio, R., Rossi, M., Nucci, C. A., Rachidi, F., Borghetti, A., Paolone, M., C. MAZZETTI, T. KAWAMURA, S. YOKOYAMA, M. ISHII, T. SHINDO, T. KAWAMURA, S. YOKOYAMA, M. ISHII, T. SHINDO, F. Delfino, R. Procopio, M. Rossi, A. Borghetti, C.A. Nucci, M. Paolone, and F. Rachidi
- Subjects
ELECTROMAGNETIC TRANSIENT PROPAGATION ,LIGHT RAIL TRANSPORTATION SYSTEM ,OVERVOLTAGE PROTECTION ,ELECTROMAGNETIC COUPLING - Abstract
This paper deals with the evaluation of lightning-induced overvoltages in a typical light-rail DC traction overhead power line. In particular, results provided by a new ad-hoc full-wave formulation are compared with those obtained by classical field-excited transmission line (TL) methods and by the general purpose NEC code based on the Method of Moment. Advantages and disadvantages of the methods are illustrated and discussed. It is shown that the full-wave formulation can be used in a circuit simulator in conjunction with a detailed representation of the light rail feeding system.
- Published
- 2006
35. Evaluation of underground lightning electromagnetic fields
- Author
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Delfino, F., Procopio, R., Rossi, M., Rachidi, F., Nucci, C.A., J. CATRYSSE, F. Delfino, R. Procopio, M. Rossi, F. Rachidi, and C. A. Nucci
- Subjects
ELECTROMAGNETIC FIELDS ,LIGHTNING ,LIGHTNING INDUCED TRANSIENTS - Published
- 2006
36. HF electromagnetic field coupling to a transmission line of finite length over a perfectly conducting ground
- Author
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Andreotti, A., Delfino, Federico, Procopio, Renato, Rossi, Mansueto, Verolino, L., A., Andreotti, F., Delfino, R., Procopio, M., Rossi, Verolino, Luigi, R., Rocopio, Andreotti, Amedeo, and L., Verolino
- Published
- 2002
37. A field-based inverse algorithm for the identification of different height lightning return strokes
- Author
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Amedeo Andreotti, Delfino, F., Girdinio, P., Verolino, L., Andreotti, Amedeo, F., Delfino, P., Girdinio, L., Verolino, Andreotti, A., Delfino, F., Girdinio, P., and Verolino, Luigi
- Published
- 2001
38. Cardiogenic shock in the context of acute coronary syndromes in Latin America ("LATIN Shock").
- Author
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Castillo Costa Y, Delfino F, Mauro V, D Imperio H, Adamowski M, Cortez Sandoval MA, Pow Chon Long F, Macín SM, Burgos Acosta J, Chacón-Díaz M, and Soldán Patiño CP
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Intra-Aortic Balloon Pumping statistics & numerical data, Intra-Aortic Balloon Pumping methods, Latin America epidemiology, Prospective Studies, ST Elevation Myocardial Infarction epidemiology, ST Elevation Myocardial Infarction therapy, ST Elevation Myocardial Infarction diagnosis, ST Elevation Myocardial Infarction complications, ST Elevation Myocardial Infarction mortality, Acute Coronary Syndrome epidemiology, Acute Coronary Syndrome complications, Acute Coronary Syndrome therapy, Acute Coronary Syndrome diagnosis, Hospital Mortality trends, Registries statistics & numerical data, Shock, Cardiogenic epidemiology, Shock, Cardiogenic etiology, Shock, Cardiogenic therapy
- Abstract
Cardiogenic shock (CS) is a serious complication of heart attack and constitutes one of its main causes of death. To date, there is no data on its treatment and evolution in Latin America., Objectives: To know the clinical characteristics, treatment strategies, evolution and in-hospital mortality of CS in Latin America., Materials and Methods: This is a prospective, multicenter registry of patients hospitalized with CS in the context of acute coronary syndromes (ACS) with and without ST segment elevation for 24 months., Results: 41 Latin American centers participated incorporating patients during the period between October 2021 and September 2023. 278 patients were included. Age: 66 (59-75) years, 70.1 % men. 74.8 % of the cases correspond to ACS with ST elevation, 14.4 % to ACS without ST elevation, 5.7 % to right ventricular infarction and 5.1 % to mechanical complications. CS was present from admission in 60 % of cases. Revascularization: 81.3 %, inotropic use: 97.8 %, ARM: 52.5 %, Swan Ganz: 17 %, intra-aortic balloon pump: 22.2 %. Overall in-hospital mortality was 52.7 %, with no differences between ACS with or without ST., Conclusions: Morbidity and mortality is very high despite the high reperfusion used., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
39. ARGEN SHOCK: Mortality related to the use of Swan Ganz and to the hemodynamic pattern found in patients with AMICS.
- Author
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Costa YC, Delfino F, Mauro V, Charask A, Fairman E, Macín SM, Perea J, D'Imperio H, Fernández A, and Barrero C
- Subjects
- Humans, Treatment Outcome, Shock, Cardiogenic therapy, Hemodynamics, Myocardial Infarction diagnosis, Cardiovascular Agents
- Abstract
The Swan Ganz Catheter (SGC) allows us to diagnose different types of cardiogenic shock (CS)., Objectives: 1) Determine the frequency of use of SGC, 2) Analyze the clinical characteristics and mortality according to its use and 3) Analyze the prevalence, clinical characteristics and mortality according to the type of Shock., Methods: The 114 patients (p) from the ARGEN SHOCK registry were analyzed. A "classic" pattern was defined as PCP > 15 mm Hg, CI < 2.2 L/min/ m2, SVR > 1,200 dynes × sec × cm-5. A "vasoplegic/mixed" pattern was defined when p did not meet the classic definition. CS due to right ventricle (RV) was excluded., Results: SGC was used in 35 % (n:37). There were no differences in clinical characteristics according to SGC use, but those with SGC were more likely to receive dobutamine, levosimendan, and intra aortic balloon pump (IABP). Mortality was similar (59.4 % vs 61.3 %). The pattern was "classic" in 70.2 %. There were no differences in clinical characteristics according to the type of pattern or the drugs used. Mortality was 54 % in patients with the classic pattern and 73 % with the mixed/vasoplegic pattern, but the difference did not reach statistical significance (p:0.23)., Conclusions: SGC is used in one third of patients with CS. Its use does not imply differences in the drugs used or in mortality. Most patients have a classic hemodynamic pattern. There are no differences in mortality or in the type of vasoactive agents used according to the CS pattern found., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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40. [ARGEN-IAM-ST Registry: older adults with infarction: Are they all the same?]
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Castillo Costa Y, Delfino F, Palacio S, Charask A, Mauro V, Macín S, Zapata G, D Imperio H, Thierer J, and Gagliardi J
- Subjects
- Humans, Female, Aged, Male, Middle Aged, Age Factors, Aged, 80 and over, Myocardial Infarction mortality, Myocardial Infarction epidemiology, Myocardial Infarction therapy, ST Elevation Myocardial Infarction mortality, ST Elevation Myocardial Infarction epidemiology, ST Elevation Myocardial Infarction therapy, Argentina epidemiology, Registries, Hospital Mortality
- Abstract
Introduction: Currently the patient is defined as an older adult (OA) when the age is at least 60 years. Given the long life expectancy, it is interesting to evaluate whether all OAs with acute myocardial infarction (AMI) are equal. The objectives were to know the prevalence of OA in AMI and within them, that of those ≥75 years of age and to analyze characteristics, reperfusion treatments and in-hospital mortality according to whether they are < or ≥ 75 years of age., Methods: OA patients admitted to the National Registry of Infarction with ST segment elevation (ARGENIAM-ST) were analyzed. They were divided into group 1: 60-74 years old and group 2: ≥ 75 years old and compared with each other., Results: 3626 AM, 75.9% from Group 1, the rest from Group 2. In group 2 there were more women, hypertensive and with a history of coronary arteries. There was a similar percentage of diabetes and dyslipidemia, but fewer of smokers. In Group 2, less reperfusion treatment was used (although more primary angioplasty), with similar door-to-balloon time. Patients in Group 2 received fewer medications of proven efficacy and in the hospital course, they had more bleeding (although not major), more heart failure and more mortality: 18.3% vs. 9.4%, p<0.001. Age ≥75 years was an independent predictor of mortality., Conclusions: one in four patients with AMI is over 75 years old; they receive less reperfusion, have more heart failure, bleeding and twice the mortality rate than patients between 60 and 74 years.
- Published
- 2024
41. Clinical characteristics and evolution of patients with cardiogenic shock in Argentina in the context of an acute myocardial infarction with ST segment elevation. Data from the nationwide ARGEN-IAM-ST Registry.
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Castillo Costa Y, Delfino F, Mauro V, D'Imperio H, Barrero C, Charask A, Zoni R, Macín S, Perna E, and Gagliardi J
- Subjects
- Humans, Female, Shock, Cardiogenic epidemiology, Shock, Cardiogenic etiology, Shock, Cardiogenic therapy, Argentina epidemiology, Registries, Treatment Outcome, Myocardial Infarction epidemiology, Myocardial Infarction therapy, ST Elevation Myocardial Infarction epidemiology, ST Elevation Myocardial Infarction therapy, Heart Arrest complications
- Abstract
Cardiogenic Shock is one of the main causes of death in ST segment Elevation Myocardial Infarction. To know the clinical characteristics, in-hospital evolution and mortality of patients with Cardiogenic Shock. Patients enrolled in the ARGEN-IAM-ST Registry were analyzed. Predictors of Cardiogenic Shock and death during hospital stay were established. A total of 6122 patients were admitted between 2015 and 2022. Cardiogenic Shock was present in 10.75% of cases. Patients with CS were older (64.5 vs 60 years), more females (41% vs 36%), with more antecedents of infarction and a higher prevalence of anterior location of infarction and multivessel disease. They were also less revascularized (88.5% vs 91.5%) and had a higher incidence of failed angioplasty (15.7% vs 2.7%). They also evidenced a higher occurrence of mechanical complications (6.8% vs 0.4%), ischemic recurrence (7.4% vs 3.4%) and cardiac arrest on admission (44.8% vs 2.6%). All the differences described showed statistical significance with P < 0.05. Overall mortality was 58% in contrast to 2.77% in patients without Cardiogenic Shock (P < 0.001). Only age, DBT, and early cardiac arrest were independent predictors of shock on admission whereas age, female gender, cardiac arrest on admission and failed angioplasty were independent predictors of death. One out of 10 patients with ST Elevation Myocardial Infarction presented cardiogenic shock. Its clinical characteristics were similar to those described more than 20 years ago. Despite a high use of reperfusion strategy cardiogenic shock continues to have a very high mortality Argentina., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2023
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42. Allogeneic CD20-targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B-cell lymphoma models.
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Nishimoto KP, Barca T, Azameera A, Makkouk A, Romero JM, Bai L, Brodey MM, Kennedy-Wilde J, Shao H, Papaioannou S, Doan A, Masri C, Hoang NT, Tessman H, Ramanathan VD, Giner-Rubio A, Delfino F, Sharma K, Bray K, Hoopes M, Satpayev D, Sengupta R, Herrman M, Abbot SE, Aftab BT, An Z, Panuganti S, and Hayes SM
- Abstract
Objectives: Autologous chimeric antigen receptor (CAR) αβ T-cell therapies have demonstrated remarkable antitumor efficacy in patients with haematological malignancies; however, not all eligible cancer patients receive clinical benefit. Emerging strategies to improve patient access and clinical responses include using premanufactured products from healthy donors and alternative cytotoxic effectors possessing intrinsic tumoricidal activity as sources of CAR cell therapies. γδ T cells, which combine innate and adaptive mechanisms to recognise and kill malignant cells, are an attractive candidate platform for allogeneic CAR T-cell therapy. Here, we evaluated the manufacturability and functionality of allogeneic peripheral blood-derived CAR
+ Vδ1 γδ T cells expressing a second-generation CAR targeting the B-cell-restricted CD20 antigen., Methods: Donor-derived Vδ1 γδ T cells from peripheral blood were ex vivo -activated, expanded and engineered to express a novel anti-CD20 CAR. In vitro and in vivo assays were used to evaluate CAR-dependent and CAR-independent antitumor activities of CD20 CAR+ Vδ1 γδ T cells against B-cell tumors., Results: Anti-CD20 CAR+ Vδ1 γδ T cells exhibited innate and adaptive antitumor activities, such as in vitro tumor cell killing and proinflammatory cytokine production, in addition to in vivo tumor growth inhibition of B-cell lymphoma xenografts in immunodeficient mice. Furthermore, CD20 CAR+ Vδ1 γδ T cells did not induce xenogeneic graft-versus-host disease in immunodeficient mice., Conclusion: These preclinical data support the clinical evaluation of ADI-001, an allogeneic CD20 CAR+ Vδ1 γδ T cell, and a phase 1 study has been initiated in patients with B-cell malignancies (NCT04735471)., Competing Interests: KPN, TB, AA, AM, JMR, LB, MMB, JK‐W, HS, SP, AD, CM, NTH, HT, VDR, AG‐R, M Hoopes, DS, RS, M Herrman, SEA, BTA, ZA, SP and SMH are, or were, employees of Adicet Bio, Inc., and FD, KS and KB are employees of Regeneron Pharmaceuticals, Inc., (© 2022 Adicet Bio Inc. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.)- Published
- 2022
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43. Development of Novel Glucocorticoids for Use in Antibody-Drug Conjugates for the Treatment of Inflammatory Diseases.
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Han A, Olsen O, D'Souza C, Shan J, Zhao F, Yanolatos J, Hovhannisyan Z, Haxhinasto S, Delfino F, and Olson W
- Subjects
- Animals, Budesonide metabolism, Budesonide pharmacokinetics, Cathepsin B metabolism, Glucocorticoids chemical synthesis, Glucocorticoids metabolism, Glucocorticoids pharmacokinetics, Humans, Immunoconjugates chemistry, Immunoconjugates immunology, Immunoconjugates metabolism, Inflammation chemically induced, Inflammation immunology, Lipopolysaccharides, Male, Mice, Inbred C57BL, Molecular Docking Simulation, Molecular Structure, Receptors, Glucocorticoid metabolism, Receptors, Prolactin immunology, Structure-Activity Relationship, Mice, Budesonide analogs & derivatives, Budesonide therapeutic use, Glucocorticoids therapeutic use, Immunoconjugates therapeutic use, Inflammation drug therapy
- Abstract
Glucocorticoids (GCs) are widely used to treat a variety of autoimmune and inflammatory diseases; however, systemic delivery of GCs is associated with side effects that affect essentially every organ system, reflecting the nearly ubiquitous expression of the glucocorticoid receptor (GR). Targeted delivery of GCs to diseased tissues using antibody-glucocorticoid conjugates (GC-ADCs) offers a therapeutic alternative to overcome these adverse effects. Herein, we describe novel classes of GCs that exhibited greater potency than dexamethasone and budesonide, a 100-fold selectivity toward the GR over other nuclear receptors, and no in vitro safety liability in pharmacology assays (hERG, AMES) and that demonstrated a substantial reduction in tumor necrosis factor-α (TNF-α) release in mice challenged with lipopolysaccharide (LPS). The site-specific conjugated GC-ADCs via cathepsin-cleavable linkers were highly stable in plasma and specifically released GCs in antigen-positive cells, suggesting that these novel GCs can serve as ADC payloads to treat autoimmune and inflammatory diseases.
- Published
- 2021
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44. Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning.
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Haber L, Olson K, Kelly MP, Crawford A, DiLillo DJ, Tavaré R, Ullman E, Mao S, Canova L, Sineshchekova O, Finney J, Pawashe A, Patel S, McKay R, Rizvi S, Damko E, Chiu D, Vazzana K, Ram P, Mohrs K, D'Orvilliers A, Xiao J, Makonnen S, Hickey C, Arnold C, Giurleo J, Chen YP, Thwaites C, Dudgeon D, Bray K, Rafique A, Huang T, Delfino F, Hermann A, Kirshner JR, Retter MW, Babb R, MacDonald D, Chen G, Olson WC, Thurston G, Davis S, Lin JC, and Smith E
- Abstract
T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumor cells. The promising preclinical and clinical efficacy of TSAxCD3 antibodies is often accompanied by toxicities such as cytokine release syndrome due to T-cell activation. How the efficacy and toxicity profile of the TSAxCD3 bispecific antibodies depends on the binding affinity to CD3 remains unclear. Here, we evaluate bispecific antibodies that were engineered to have a range of CD3 affinities, while retaining the same binding affinity for the selected tumor antigen. These agents were tested for their ability to kill tumor cells in vitro, and their biodistribution, serum half-life, and anti-tumor activity in vivo. Remarkably, by altering the binding affinity for CD3 alone, we can generate bispecific antibodies that maintain potent killing of TSA + tumor cells but display differential patterns of cytokine release, pharmacokinetics, and biodistribution. Therefore, tuning CD3 affinity is a promising method to improve the therapeutic index of T-cell-engaging bispecific antibodies., (© 2021. The Author(s).)
- Published
- 2021
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45. A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells.
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DiLillo DJ, Olson K, Mohrs K, Meagher TC, Bray K, Sineshchekova O, Startz T, Kuhnert J, Retter MW, Godin S, Sharma P, Delfino F, Lin J, Smith E, Thurston G, and Kirshner JR
- Subjects
- Animals, B-Cell Maturation Antigen, Humans, Immunotherapy, Adoptive, Mice, T-Lymphocytes, Antibodies, Bispecific therapeutic use, Multiple Myeloma drug therapy
- Abstract
CD3-engaging bispecific antibodies (bsAbs) and chimeric antigen receptor (CAR) T cells are potent therapeutic approaches for redirecting patient T cells to recognize and kill tumors. Here we describe a fully human bsAb (REGN5458) that binds to B-cell maturation antigen (BCMA) and CD3, and compare its antitumor activities vs those of anti-BCMA CAR T cells to identify differences in efficacy and mechanism of action. In vitro, BCMAxCD3 bsAb efficiently induced polyclonal T-cell killing of primary human plasma cells and multiple myeloma (MM) cell lines expressing a range of BCMA cell surface densities. In vivo, BCMAxCD3 bsAb suppressed the growth of human MM tumors in murine xenogeneic models and showed potent combinatorial efficacy with programmed cell death protein 1 blockade. BCMAxCD3 bsAb administration to cynomolgus monkeys was well tolerated, resulting in the depletion of BCMA+ cells and mild inflammatory responses characterized by transient increases in C-reactive protein and serum cytokines. The antitumor efficacy of BCMAxCD3 bsAb was compared with BCMA-specific CAR T cells containing a BCMA-binding single-chain variable fragment derived from REGN5458. Both BCMAxCD3 bsAb and anti-BCMA CAR T cells showed similar targeted cytotoxicity of MM cell lines and primary MM cells in vitro. In head-to-head in vivo studies, BCMAxCD3 bsAb rapidly cleared established systemic MM tumors, whereas CAR T cells cleared tumors with slower kinetics. Thus, using the same BCMA-binding domain, these results suggest that BCMAxCD3 bsAb rapidly exerts its therapeutic effects by engaging T cells already in place at the tumor site, whereas anti-BCMA CAR T cells require time to traffic to the tumor site, activate, and numerically expand before exerting antitumor effects., (© 2021 by The American Society of Hematology.)
- Published
- 2021
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46. Diabetes as a Predictor of In-Hospital and One-Year Outcomes After Decompensated Heart Failure.
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Fairman E, Delfino F, Mauro V, Charask A, Castillo Costa Y, Rafaelli A, Rojo L, Rodríguez Rowain V, Cáceres L, and Barrero C
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- Age Factors, Aged, 80 and over, Female, Hospitals, Humans, Male, Prognosis, Diabetes Mellitus mortality, Heart Failure mortality
- Abstract
Diabetes and heart failure are closely interdependent, but its significance in decompensated heart failure (DHF) is not uniformly accepted., Objective: To compare mortality between diabetics and nondiabetics with DHF., Methods and Results: In-hospital and 1-year mortality of 1004 consecutive patients with DHF: 25.6% diabetics; median age was 81, 53% male. Diabetics were younger, more often male, with higher prevalence of ischemic etiology and reduced ejection fraction. Congestion was the most prevalent finding in both groups. In hospital mortality was 6.3% vs 6.6 % in nondiabetics and diabetics respectively and 1-year mortality was 35.77% in nondiabetics and 29.3% in diabetics. There were no significant differences in mortality at univariate and multivariate analyses. We applied a propensity score restricted to 378 patients, 189 (50%) diabetics and 189 (50%) and no significant differences were found., Conclusion: Diabetes had no impact on prognosis in DHF. Advanced age may played a major role in outcomes i thus making less relevant the presence of diabetes., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2021
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47. In silico design, building and gas adsorption of nano-porous graphene scaffolds.
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Bellucci L, Delfino F, and Tozzini V
- Abstract
Graphene-based nano-porous materials (GNM) are potentially useful for all those applications needing a large specific surface area (SSA), typical of the bidimensional graphene, yet realized in the bulk dimensionality. Such applications include for instance gas storage and sorting, catalysis and electrochemical energy storage. While a reasonable control of the structure is achieved in micro-porous materials by using nano-micro particles as templates, the controlled production or even characterization of GNMs with porosity strictly at the nano-scale still raises issues. These are usually produced using dispersion of nano-flakes as precursors resulting in little control on the final structure, which in turn reflects in problems in the structural model building for computer simulations. In this work, we describe a strategy to build models for these materials with predetermined structural properties (SSA, density, porosity), which exploits molecular dynamics simulations, Monte Carlo methods and machine learning algorithms. Our strategy is inspired by the real synthesis process: starting from randomly distributed flakes, we include defects, perforation, structure deformation and edge saturation on the fly, and, after structural refinement, we obtain realistic models, with given structural features. We find relationships between the structural characteristics and size distributions of the starting flake suspension and the final structure, which can give indications for more efficient synthesis routes. We subsequently give a full characterization of the models versus H
2 adsorption, from which we extract quantitative relationship between the structural parameters and the gravimetric density. Our results quantitatively clarify the role of surfaces and edges relative amount in determining the H2 adsorption, and suggest strategies to overcome the inherent physical limitations of these materials as adsorbers. We implemented the model building and analysis procedures in software tools, freely available upon request.- Published
- 2021
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48. Antibody drug conjugates of cleavable amino-benzoyl-maytansinoids.
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Nittoli T, Delfino F, Kelly M, Carosso S, Markotan T, Kunz A, Chen Z, Mao S, Shan J, Navarro E, Zhao F, Makonnen S, Hickey C, Spink J, Olson W, Kirshner JR, Thurston G, and Papadopoulos N
- Subjects
- Animals, Cell Line, Cell Line, Tumor, Cell Survival drug effects, Female, Humans, Immunoconjugates chemistry, Immunoconjugates pharmacology, Immunoconjugates therapeutic use, Maytansine metabolism, Mice, SCID, Neoplasms drug therapy, Neoplasms pathology, Structure-Activity Relationship, Transplantation, Heterologous, Tubulin Modulators metabolism, Immunoconjugates metabolism, Maytansine chemistry, Tubulin Modulators chemistry
- Abstract
ADCs based on the natural product maytansine have been successfully employed clinically. In a previous report, ADCs based on hydrophilic non-cell permeable maytansinoids was presented. The authors in this report further explore the maytansine scaffold to develop tubulin inhibitors capable of cell permeation. The research resulted in amino-benzoyl-maytansinoid payloads that were further elaborated with linkers for conjugating to antibodies. This approach was applied to MUC16 tumor targeting antibodies for ovarian cancers. A positive control ADC was evaluated alongside the amino-benzoyl-maytansinoid ADC and the efficacy observed was equivalent while the isotype control ADCs had no effect., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
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49. Flexibility Services Based on OpenADR Protocol for DSO Level.
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Guerrero Alonso JI, Personal E, García S, Parejo A, Rossi M, García A, Delfino F, Pérez R, and León C
- Abstract
Nowadays, Distribution System Operators are increasing the digitalization of their smart grids, making it possible to measure and manage their state at any time. However, with the massive eruption of change-distributed generation (e.g., renewable resources, electric vehicles), the grid operation have become more complex, requiring specific technologies to balance it. In this sense, the demand-side management is one of its techniques; the demand response is a promising approach for providing Flexibility Services (FSs) and complying with the regulatory directives of the energy market. As a solution, this paper proposes the use of the OpenADR (Open Automated Demand Response) standard protocol in combination with a Decentralized Permissioned Market Place (DPMP) based on Blockchain. On one hand, OpenADR hierarchical architecture based on distributed nodes provides communication between stakeholders, adding monitoring and management services. Further, this architecture is compatible with an aggregator schema that guarantees the compliance with the strictest regulatory framework (i.e., European market). On the other hand, DPMP is included at different levels of this architecture, providing a global solution to Flexibility Service Providers (FSP) that can be adapted depending on the regulation of a specific country. As a proof of concept, this paper shows the result of a real experimental case, which implements a Capacity Bidding Program where the OpenADR protocol is used as a communication method to control and monitor energy consumption. In parallel, the proposed DPMP based on Blockchain makes it possible to manage the incentives of FSs, enabling the integration of local and global markets.
- Published
- 2020
- Full Text
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50. Use of traffic crash as a risk assessment scale in hospitalized seniors: a perspective observational study.
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Guasconi M, Pisaroni N, Bertuol M, Scazzariello M, Delfino F, Bolzoni M, Grossi CF, Beretta M, Marchetti A, Boselli A, Sarli L, and Artioli G
- Subjects
- Aged, Humans, Prospective Studies, Reproducibility of Results, Accidental Falls statistics & numerical data, Accidents, Traffic statistics & numerical data, Hospitalization statistics & numerical data, Risk Assessment methods
- Abstract
Background and Aim: According to the World Health Organization (WHO), falls represent the second main cause of accidental and involuntary deaths worldwide, which led to define them as one of the "four giants of the geriatrician" that particularly affect the elderly aged ≥ 65 years. The study's aim is to evaluate whether the Traffic Crash scale is valid in identifying patients at risk of falling by comparing it to the Conley scale currently used., Methods: Prospective observational study evaluating the fall risk using TC on a sample of patients aged ≥ 65 years, hospitalized in General Medicine Ward and Gastroenterology, after informed consent and favorable opinion of the AVEN Ethics Committee. The results are compared with those obtained from the Conley scale, and with those obtained from the indications of the Business Operating Instruction. The method of administration occurred concurrently and distinctly on the same patient by two researchers in order to demonstrate the scale inter-rater reliability., Results: The final sample was made up of 88 patients. Data shows that 46 out of 55 patients (84%) are medium / high risk for both scales. According to the indications of the Company Operating Instruction, the entire sample is at risk. The inter-rater reliability was confirmed with Cohen's K which is equal to p = 1., Conclusions: The TC scale is comparable to Conley scale, for the fall risk identification but specifically the stratification is low-medium-high. Therefore, in future, this will make it possible to implement personalized prevention interventions in care planning.
- Published
- 2020
- Full Text
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