1. Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report.
- Author
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Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernández LÁ, Lora JM, Kaufman HL, Quintana FJ, Geiger R, F Lesser C, Lynch JP, Hava DL, Cornish VW, Lee GK, DiAndreth B, Fero M, Srivastava R, De Coster T, Roybal KT, Rackham OJL, Kiani S, Zhu I, Hernandez-Lopez RA, Guo T, and Chen WCW
- Subjects
- Animals, Cell- and Tissue-Based Therapy methods, Cell- and Tissue-Based Therapy trends, Gene Targeting methods, Gene Targeting trends, Genetic Engineering methods, Genetic Therapy methods, Humans, Killer Cells, Natural immunology, Machine Learning trends, Synthetic Biology methods, T-Lymphocytes immunology, Congresses as Topic trends, Genetic Engineering trends, Genetic Therapy trends, Research Report, Synthetic Biology trends
- Abstract
Synthetic biology has the potential to transform cell- and gene-based therapies for a variety of diseases. Sophisticated tools are now available for both eukaryotic and prokaryotic cells to engineer cells to selectively achieve therapeutic effects in response to one or more disease-related signals, thus sparing healthy tissue from potentially cytotoxic effects. This report summarizes the Keystone eSymposium "Synthetic Biology: At the Crossroads of Genetic Engineering and Human Therapeutics," which took place on May 3 and 4, 2021. Given that several therapies engineered using synthetic biology have entered clinical trials, there was a clear need for a synthetic biology symposium that emphasizes the therapeutic applications of synthetic biology as opposed to the technical aspects. Presenters discussed the use of synthetic biology to improve T cell, gene, and viral therapies, to engineer probiotics, and to expand upon existing modalities and functions of cell-based therapies., (© 2021 New York Academy of Sciences.)
- Published
- 2021
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