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2. Development of $$^{100}\hbox {Mo}$$ 100 Mo -containing scintillating bolometers for a high-sensitivity neutrinoless double-beta decay search

Author

E. Armengaud, C. Augier, A. S. Barabash, J. W. Beeman, T. B. Bekker, F. Bellini, A. Benoît, L. Bergé, T. Bergmann, J. Billard, R. S. Boiko, A. Broniatowski, V. Brudanin, P. Camus, S. Capelli, L. Cardani, N. Casali, A. Cazes, M. Chapellier, F. Charlieux, D. M. Chernyak, M. de Combarieu, N. Coron, F. A. Danevich, I. Dafinei, M. De Jesus, L. Devoyon, S. Di Domizio, L. Dumoulin, K. Eitel, C. Enss, F. Ferroni, A. Fleischmann, N. Foerster, J. Gascon, L. Gastaldo, L. Gironi, A. Giuliani, V. D. Grigorieva, M. Gros, L. Hehn, S. Hervé, V. Humbert, N. V. Ivannikova, I. M. Ivanov, Y. Jin, A. Juillard, M. Kleifges, V. V. Kobychev, S. I. Konovalov, F. Koskas, V. Kozlov, H. Kraus, V. A. Kudryavtsev, M. Laubenstein, H. Le Sueur, M. Loidl, P. Magnier, E. P. Makarov, M. Mancuso, P. de Marcillac, S. Marnieros, C. Marrache-Kikuchi, S. Nagorny, X-F. Navick, M. O. Nikolaichuk, C. Nones, V. Novati, E. Olivieri, L. Pagnanini, P. Pari, L. Pattavina, M. Pavan, B. Paul, Y. Penichot, G. Pessina, G. Piperno, S. Pirro, O. Plantevin, D. V. Poda, E. Queguiner, T. Redon, M. Rodrigues, S. Rozov, C. Rusconi, V. Sanglard, K. Schäffner, S. Scorza, V. N. Shlegel, B. Siebenborn, O. Strazzer, D. Tcherniakhovski, C. Tomei, V. I. Tretyak, V. I. Umatov, L. Vagneron, Ya. V. Vasiliev, M. Velázquez, M. Vignati, M. Weber, E. Yakushev, and A. S. Zolotarova

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract This paper reports on the development of a technology involving $$^{100}\hbox {Mo}$$ 100 Mo -enriched scintillating bolometers, compatible with the goals of CUPID, a proposed next-generation bolometric experiment to search for neutrinoless double-beta decay. Large mass ( $$\sim 1~\hbox {kg}$$ ∼ 1 kg ), high optical quality, radiopure $$^{100}\hbox {Mo}$$ 100 Mo -containing zinc and lithium molybdate crystals have been produced and used to develop high performance single detector modules based on 0.2–0.4 kg scintillating bolometers. In particular, the energy resolution of the lithium molybdate detectors near the Q-value of the double-beta transition of $$^{100}\hbox {Mo}$$ 100 Mo (3034 keV) is 4–6 keV FWHM. The rejection of the $$\alpha $$ α -induced dominant background above 2.6 MeV is better than $$8\sigma $$ 8 σ . Less than $$10~\upmu \hbox {Bq/kg}$$ 10 μ Bq/kg activity of $$^{232}\hbox {Th}\, (^{228}\hbox {Th})$$ 232 Th ( 228 Th ) and $$^{226}\hbox {Ra}$$ 226 Ra in the crystals is ensured by boule recrystallization. The potential of $$^{100}\hbox {Mo}$$ 100 Mo -enriched scintillating bolometers to perform high sensitivity double-beta decay searches has been demonstrated with only $$10~\hbox {kg}\times \hbox {d}$$ 10 kg × d exposure: the two neutrino double-beta decay half-life of $$^{100}\hbox {Mo}$$ 100 Mo has been measured with the up-to-date highest accuracy as $$T_{1/2}$$ T 1 / 2 = [6.90 ± 0.15(stat.) ± 0.37(syst.)] $$\times ~10^{18}~\hbox {years}$$ × 10 18 years . Both crystallization and detector technologies favor lithium molybdate, which has been selected for the ongoing construction of the CUPID-0/Mo demonstrator, containing several kg of $$^{100}\hbox {Mo}$$ 100 Mo .

Published
2017
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7. Lesiones oclusivas ateromatosas crónicas de la aorta y de los miembros inferiores

Author

F. Koskas and Y. Georg

Abstract

Las lesiones oclusivas ateromatosas cronicas de la aorta y de los miembros inferiores son una localizacion frecuente de la enfermedad ateromatosa, que es un trastorno sistemico. Constituyen el reflejo de una afeccion polivascular general que puede comprometer el pronostico vital debido a sus localizaciones coronarias y cerebrales. Las lesiones oclusivas aorticas y de los miembros inferiores pueden mantenerse durante mucho tiempo asintomaticas gracias a distintos mecanismos de suplencia, pero cuando se vuelven sintomaticas, pueden comprometer los pronosticos funcional y tisular de los miembros inferiores y de la pelvis. En este contexto, el tratamiento vascular ha experimentado los mayores progresos en los ultimos anos, no solo en cuanto al tratamiento medico y las tecnicas de revascularizacion, sino tambien en la clarificacion de las indicaciones terapeuticas. El ateroma se comprende mejor como una enfermedad sistemica. Estas lesiones oclusivas requieren un tratamiento medico que, en la actualidad, tiene varias dianas y pueden requerir un procedimiento de revascularizacion. Para establecer las indicaciones terapeuticas, se requiere una exploracion de calidad, que comienza con la ecografia y en la que las exploraciones con contraste yodado son el elemento central. El arsenal terapeutico disponible es muy amplio y sus progresos tecnologicos son constantes. Las tecnicas quirurgicas de revascularizacion se han vuelto mas seguras en paralelo al desarrollo de las tecnicas endovasculares. La asociacion del tratamiento medico y de los tratamientos quirurgicos convencionales y/o endovasculares permite responder a las expectativas de un mayor numero de pacientes.

Published
2013
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9. Pie diabético

Author

G. Ha Van, A. Hartemann, F. Gautier, J. Haddad, Y. Bensimon, W. Ponseau, J. Baillot, E. Fourniols, F. Koskas, and A. Grimaldi

Published
2012
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10. Pied diabétique

Author

G. Ha Van, A. Hartemann-Heurtier, F. Gautier, J. Haddad, Y. Bensimon, W. Ponseau, J. Baillot, E. Fourniols, F. Koskas, and A. Grimaldi

Published
2011
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11. Aspect réglementaire d’une production hospitalière d’endoprothèses sur mesure

Author

R. Farinotti, J.-D. Singland, J.-M. Kaiser, F. Koskas, C. Fargeot, and J. Molina

Subjects
Pharmacology (medical)
Abstract

Resume Introduction Le traitement des anevrismes de l’aorte abdominale par endoprotheses vasculaires sur mesure (EVSM) est developpe a la Pitie-Salpetriere depuis plus de dix ans et a permis de traiter plus de 400 patients. Cependant, le statut reglementaire de ces EVSM confectionnees a l’hopital n’est pas aussi simple a definir que celui des implants industriels. Objectif Evaluer les conditions de production de ces EVSM, et leur conformite avec le contexte reglementaire, afin d’envisager un remboursement. Methode Recherche documentaire avec analyse des textes, puis recueil des avis aupres des organismes notifies. Resultats Pour l’Agence francaise de securite sanitaire des produits de sante (Afssaps), le marquage CE de ces dispositif medical implantable (DMI) n’est pas une necessite, le dispositif etant assimile a une preparation de type magistral. En revanche, selon la Haute Autorite de sante (HAS), l’inscription sur la liste des produits et prestations remboursables (LPPR) est tributaire du statut de dispositif medical et requiert donc le marquage CE pour un aval sur la procedure. Mais chaque EVSM etant unique, seul le procede de fabrication peut etre certifie. Discussion–conclusion Apres ces demarches, l’environnement reglementaire de ces DMI a ete clarifie. Toutefois, la prise en charge financiere de ces DMI innovants n’est pas resolue faute de reconnaissance appropriee. Actuellement, ces EVSM sont prises en charge par le budget du service clinique et non remboursees en sus des groupe homogene de sejour (GHS). Cette situation met en evidence la difficulte de developper des dispositifs de type « orphelin » ou innovants en dehors de l’industrie pharmaceutique.

Published
2010
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13. Radiopure ZnMoO4 scintillating bolometers for the LUMINEU double-beta experiment

Author

D. V. Poda, E. Armengaud, Q. Arnaud, C. Augier, A. S. Barabash, A. Benoît, L. Bergé, R. S. Boiko, T. Bergmann, J. Blümer, A. Broniatowski, V. Brudanin, P. Camus, A. Cazes, B. Censier, M. Chapellier, F. Charlieux, D. M. Chernyak, N. Coron, P. Coulter, G. A. Cox, F. A. Danevich, T. de Boissière, R. Decourt, M. De Jesus, L. Devoyon, A.-A. Drillien, L. Dumoulin, K. Eitel, C. Enss, D. Filosofov, A. Fleischmann, N. Fourches, J. Gascon, L. Gastaldo, G. Gerbier, A. Giuliani, M. Gros, L. Hehn, S. Henry, S. Hervé, G. Heuermann, V. Humbert, I. M. Ivanov, A. Juillard, C. Kéfélian, M. Kleifges, H. Kluck, V. V. Kobychev, F. Koskas, V. Kozlov, H. Kraus, V. A. Kudryavtsev, H. Le Sueur, M. Loidl, P. Magnier, E. P. Makarov, M. Mancuso, P. de Marcillac, S. Marnieros, C. Marrache-Kikuchi, A. Menshikov, S. G. Nasonov, X-F. Navick, C. Nones, E. Olivieri, P. Pari, B. Paul, Y. Penichot, G. Pessina, M. C. Piro, O. Plantevin, T. Redon, M. Robinson, M. Rodrigues, S. Rozov, V. Sanglard, B. Schmidt, V. N. Shlegel, B. Siebenborn, O. Strazzer, D. Tcherniakhovski, M. Tenconi, L. Torres, V. I. Tretyak, L. Vagneron, Ya. V. Vasiliev, M. Velazquez, O. Viraphong, R. J. Walker, M. Weber, E. Yakushev, X. Zhang, V. N. Zhdankov, John L. Orrell, Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institute of Theoretical and Experimental Physics [Moscow] (ITEP), National Research Center 'Kurchatov Institute' (NRC KI), Hélium : du fondamental aux applications (NEEL - HELFA), Institut Néel (NEEL), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Kiev Institute for Nuclear Research (KINR), Ukrainian Academy of Sciences, Karlsruhe Institute of Technology (KIT), Institut für Experimentelle Kernphysik [Karlsruhe] (EKP), Karlsruher Institut für Technologie (KIT), Dzhelepov Laboratory of Nuclear Problems [Dubna] (DLNP), Joint Institute for Nuclear Research (JINR), Cryogénie (NEEL - Cryo), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), University of Oxford, Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), CSNSM PS1, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Kirchhoff Institute for Physics, Universität Heidelberg [Heidelberg] = Heidelberg University, Department of Physics [Oxford], Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Nikolaev Institute of Inorganic Chemistry [Novosibirsk] (NIC), Siberian Branch of the Russian Academy of Sciences (SB RAS), University of Sheffield [Sheffield], Laboratoire National Henri Becquerel (LNHB), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institute for Anthropomatics (KIT), Laboratoire de Cryogénie (LC), Service de physique de l'état condensé (SPEC - UMR3680), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Istituto Nazionale di Fisica Nucleare (INFN), CML Ltd., Project CUPID-Mo (CUORE Upgrade with Particle Identification in Molybdenum), ANR-12-BS05-0004,LUMINEU,Expérience souterraine avec détecteurs luminescents de molybdate de zinc pour l'étude de la masse et la nature des neutrinos(2012), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Hélium : du fondamental aux applications (HELFA), Cryogénie (Cryo), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford], Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Universität Heidelberg [Heidelberg], Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
radiopurity, Zinc molybdate, scintillating bolometer, EDELWEISS, Scintillator, radiopure zinc molybdate (ZnMoO4), [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Crystal, chemistry.chemical_compound, neutrino, Double beta decay, 0103 physical sciences, crystal scintillator, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Directional solidification, Physics, Scintillation, 010308 nuclear & particles physics, Radiochemistry, double-beta decay, crystal boule, advanced directional solidification method, purification technique, chemistry, high purity Ge wafer, Neutrino
Abstract

International audience; The results of R&D of radiopure zinc molybdate (ZnMoO4) based scintillating bolometers for the LUMINEU (Luminescent Underground Molybdenum Investigation for NEUtrino mass and nature) double-beta decay experiment are presented. A dedicated two-stage molybdenum purification technique (sublimation in vacuum and recrystallization from aqueous solutions) and an advanced directional solidification method (the low-thermal-gradient Czochralski technique) were utilized to produce high optical quality large mass (∼1 kg) ZnMoO4 crystal boules and first 100Mo (99.5%) enriched Zn100MoO4 crystal scintillator (mass of ∼0.2 kg). Scintillating bolometers based on ZnMoO4 (≈ 0.33 kg) and Zn100MoO4 (≈ 0.06 kg) scintillation elements and high purity Ge wafers were tested in the EDELWEISS set-up at the Modane Underground Laboratory (France). Long term low temperature tests demonstrate excellent detectors’ performance and effectiveness of the purification and solidification procedures for the achievement of high radiopurity of the material, in particular with a bulk activity of 228Th and 226Ra below 4 µBq/kg. The adopted protocol was used to produce for the first time a large volume Zn100MoO4 crystal scintillator (mass of ∼1.4 kg, 100Mo enrichment is 99.5%) to search for neutrinoless double-beta decay of 100Mo in the framework of the LUMINEU project.

Published
2015
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14. Takayasu Arteritis and Pregnancy

Author

C, Comarmond, T, Mirault, L, Biard, J, Nizard, M, Lambert, B, Wechsler, E, Hachulla, L, Chiche, F, Koskas, J, Gaudric, P, Cluzel, E, Messas, M, Resche-Rigon, J C, Piette, P, Cacoub, and D, Saadoun

Subjects
Adult, Venous Thrombosis, Fetal Growth Retardation, Cesarean Section, Pregnancy Complications, Cardiovascular, Smoking, Pregnancy Outcome, Hypertension, Pregnancy-Induced, Severity of Illness Index, Takayasu Arteritis, Abortion, Spontaneous, Cohort Studies, Young Adult, Pre-Eclampsia, Pregnancy, Multivariate Analysis, Odds Ratio, Humans, Premature Birth, Female, Retrospective Studies
Abstract

To assess the relationship between Takayasu arteritis (TAK) and pregnancy outcome.This study included 240 pregnancies in 96 patients fulfilling the American College of Rheumatology 1990 criteria for the classification of TAK and/or the 1994 Chapel Hill Consensus Conference nomenclature/criteria for vasculitis. We analyzed obstetric and maternal outcomes in women who were pregnant before and/or at the same time as or after TAK diagnosis. We assessed factors associated with complicated pregnancy.One hundred forty-two pregnancies occurred in 52 patients before TAK diagnosis (median age at pregnancy 26 years [interquartile range 23-30 years]), and 98 pregnancies occurred in 52 patients concomitant with or after TAK diagnosis (median age at pregnancy 28 years [interquartile range 26-31 years]). Pregnancies concomitant with or after TAK diagnosis had a 13-fold higher rate of obstetric complications compared to pregnancies before TAK diagnosis (odds ratio 13 [95% confidence interval 5-33], P0.0001). TAK was associated with a 40% frequency of obstetric complications, including preeclampsia/eclampsia (24 pregnancies [24%]), premature delivery (8 pregnancies [8%]), and intrauterine fetal growth restriction or death (5 pregnancies [5%]). Maternal complications of TAK occurred during 39% of pregnancies and included mainly new-onset or worsening hypertension (26 pregnancies [27%]). In multivariate analysis, smoking (odds ratio 6.15 [95% confidence interval 1.31-28.8]) and disease activity of TAK (a National Institutes of Health score of1) (odds ratio 28.7 [95% confidence interval 7.89-104.7]) were independently associated with obstetric and maternal complications.TAK negatively affects pregnancy outcomes. Disease activity increases the risk of obstetric and maternal complications, mainly due to arterial hypertension.

Published
2015

15. Development and underground test of radiopure ZnMoO4 scintillating bolometers for the LUMINEU 0 nu 2 beta project

Author

J. Gascon, R. J. Walker, O. Plantevin, A. A. Drillien, V.N. Shlegel, M. Gros, S. Marnieros, K. Eitel, V. Kozlov, Christian Enss, M. Kleifges, B. Paul, T. de Boissière, C. Nones, C. Augier, L. Hehn, E. Olivieri, E. Yakushev, P. Coulter, C. Kéfélian, V. Humbert, G. Gerbier, M. Rodrigues, M. Chapellier, N. Foerster, A. Giuliani, S. Scorza, V. B. Brudanin, G. Heuermann, T. Redon, F. Koskas, L. Dumoulin, P. de Marcillac, Claire A. Marrache-Kikuchi, P. Magnier, S. Hervé, N. Fourches, L. Vagneron, H. Kraus, V.N. Zhdankov, A. Menshikov, M.-C. Piro, Max Robinson, Y. Penichot, X-F. Navick, Matias Velázquez, I.M. Ivanov, V. V. Kobychev, P. Pari, A. Broniatowski, R. Decourt, A. Cazes, D. Filosofov, A. Fleischmann, Oudomsack Viraphong, O. Strazzer, Denis Tcherniakhovski, G. Pessina, D. Gray, L. Gastaldo, Noël Coron, M. Loidl, Ph. Camus, L. Bergé, Alain Benoit, E.P. Makarov, V. A. Kudryavtsev, D.M. Chernyak, S. Henry, E. Armengaud, L. Devoyon, B. Schmidt, F.A. Danevich, Ya.V. Vasiliev, J. Blümer, M. Mancuso, R.S. Boiko, M. De Jesus, M. Tenconi, S. V. Rozov, Marc Weber, D.V. Poda, V.I. Tretyak, H. Kluck, T. Bergmann, Q. Arnaud, H. Le Sueur, X. Zhang, V. Sanglard, B. Siebenborn, A. Juillard, S.G. Nasonov, F. Charlieux, L. Torres, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Hélium : du fondamental aux applications (HELFA), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Kiev Institute for Nuclear Research (KINR), Ukrainian Academy of Sciences, Karlsruhe Institute of Technology (KIT), Dzhelepov Laboratory of Nuclear Problems [Dubna] (DLNP), Joint Institute for Nuclear Research (JINR), Cryogénie (Cryo), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford], Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Karlsruher Institut für Technologie (KIT), Kirchhoff Institute for Physics, Universität Heidelberg [Heidelberg], Nikolaev Institute of Inorganic Chemistry [Novosibirsk] (NIC), Siberian Branch of the Russian Academy of Sciences (SB RAS), University of Sheffield [Sheffield], Laboratoire National Henri Becquerel (LNHB), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Service de physique de l'état condensé (SPEC - UMR3680), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Istituto Nazionale di Fisica Nucleare (INFN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Université de Bordeaux (UB), CML Ltd, ANR-12-BS05-0004,LUMINEU,Expérience souterraine avec détecteurs luminescents de molybdate de zinc pour l'étude de la masse et la nature des neutrinos(2012), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Hélium : du fondamental aux applications (NEEL - HELFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Cryogénie (NEEL - Cryo), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), University of Oxford, Universität Heidelberg [Heidelberg] = Heidelberg University, Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), HELFA - Hélium : du fondamental aux applications, Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), CSNSM PS1, Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Laboratory of Particle Physics (JINR-DUBNA), Joint Institute for Nuclear Research, Cryo - Cryogénie, Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Institut Rayonnement Matière de Saclay (IRAMIS), Istituto Nazionale di Fisica Nucleare [Milano] (INFN), Joint Institute for Nuclear Research - Dubna, ANR-12-BS05-004,LUMINEU,Luminescent Underground Molybdenum Investigation for NEUtrino mass and nature, Armengaud, E, Arnaud, Q, Augier, C, Benoit, A, Berge, L, Boiko, R, Bergmann, T, Blumer, J, Broniatowski, A, Brudanin, V, Camus, P, Cazes, A, Chapellier, M, Charlieux, F, Chernyak, D, Coron, N, Coulter, P, Danevich, F, De Boissiere, T, Decourt, R, Jesus, M, Devoyon, L, Drillien, A, Dumoulin, L, Eitel, K, Enss, C, Filosofov, D, Fleischmann, A, Foerster, N, Fourches, N, Gascon, J, Gastaldo, L, Gerbier, G, Giuliani, A, Gray, D, Gros, M, Hehn, L, Henry, S, Herve, S, Heuermann, G, Humbert, V, Ivanov, I, Juillard, A, Kefelian, C, Kleifges, M, Kluck, H, Kobychev, V, Koskas, F, Kozlov, V, Kraus, H, Kudryavtsev, V, Sueur, H, Loidl, M, Magnier, P, Makarov, E, Mancuso, M, De Marcillac, P, Marnieros, S, Marrache-Kikuchi, C, Menshikov, A, Nasonov, S, Navick, X, Nones, C, Olivieri, E, Pari, P, Paul, B, Penichot, Y, Pessina, G, Piro, M, Plantevin, O, Poda, D, Redon, T, Robinson, M, Rodrigues, M, Rozov, S, Sanglard, V, Schmidt, B, Scorza, S, Shlegel, V, Siebenborn, B, Strazzer, O, Tcherniakhovski, D, Tenconi, M, Torres, L, Tretyak, V, Vagneron, L, Vasiliev, Y, Velazquez, M, Viraphong, O, Walker, R, Weber, M, Yakushev, E, Zhang, X, and Zhdankov, V

Subjects
gas and liquid scintillators), Zinc molybdate, Cryogenic detector, EDELWEISS, Scintillator, 01 natural sciences, Nuclear physics, CRYSTAL SCINTILLATORS, chemistry.chemical_compound, Double beta decay, 0103 physical sciences, Dilution refrigerator, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], 010306 general physics, Instrumentation, GRADIENT CZOCHRALSKI TECHNIQUE, Mathematical Physics, Physics, TUNGSTATES, 010308 nuclear & particles physics, Hybrid detector, DOUBLE-BETA-DECAY, Hybrid detectors, Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators), Double-beta decay detectors, Double-beta decay detector, DARK-MATTER SEARCH, scintillation and light emission processes (solid, RADIOACTIVE CONTAMINATION, Cryogenic detectors, chemistry, Scintillators, LUMINESCENCE, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], PARTICLE PHYSICS, GROWTH, SINGLE-CRYSTALS, Neutrino, Isotopes of thorium, Radioactive decay
Abstract

International audience; The LUMINEU (Luminescent Underground Molybdenum Investigation for NEUtrino mass and nature) project envisages a high-sensitivity search for neutrinoless double beta (0 nu 2 beta) decay of Mo-100 with the help of scintillating bolometers based on zinc molybdate (ZnMoO4) crystals. One of the crucial points for the successful performance of this experiment is the development of a protocol for producing high quality large mass ZnMoO4 crystal scintillators with extremely high internal radiopurity. Here we report a significant progress in the development of large volume ZnMoO4 crystalline boules (with mass up to 1 kg) from deeply purified materials. We present and discuss the results achieved with two ZnMoO4 samples (with mass of about 0.3 kg each): one is a precursor of the LUMINEU project, while the other one was produced in the framework of LUMINEU with an improved purification / crystallization procedure. The two crystals were measured deep underground as scintillating bolometers in the EDELWEISS dilution refrigerator at the Laboratoire Souterrain de Modane (France) protected by a rock overburden corresponding to 4800 m w.e. The results indicate that both tested crystals are highly radiopure. However, the advanced LUMINEU sample shows a clear improvement with respect to the precursor, exhibiting only a trace internal contamination related with Po-210 at the level of 1 mBq/kg, while the activity of Ra-226 and Th-228 is below 0.005 mBq/kg. This demonstrates that the LUMINEU purification and crystal-growth procedures are very efficient and leads to radiopurity levels which exceedingly satisfy not only the LUMINEU goals but also the requirements of a next-generation 0 nu 2 beta experiment.

Published
2015
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16. Les malformations vasculaires à développement intramusculaire : un diagnostic différentiel rare de myosite focale

Author

Christian Pagnoux, Patrick Cherin, O. Dubourg, F. Koskas, and A. Froissart

Subjects
Gynecology, medicine.medical_specialty, business.industry, Focal myositis, Diagnostico diferencial, Gastroenterology, Internal Medicine, Medicine, business
Abstract

Resume Introduction. – Les myosites focales constituent une entite pathologique originale et rare, caracterisee par une inflammation localisee d'un muscle squelettique et se traduisant cliniquement par une tumefaction douloureuse des tissus mous. Le diagnostic de certitude necessite un examen histologique en raison de l'aspect clinique peu specifique et des nombreux diagnostics differentiels. Exegese. – Nous rapportons le cas d'un homme de 27 ans qui avait consulte pour une symptomatologie evocatrice de myosite focale. Les resultats des examens d'imagerie (IRM, echographie) etaient compatibles avec ce diagnostic mais suggeraient egalement l'existence d'une composante vasculaire au sein de cette tumefaction. Seule la biopsie musculaire chirurgicale a finalement permis le diagnostic de malformation vasculaire benigne a developpement intramusculaire. Conclusion. – Ces malformations vasculaires forment un groupe histologique heterogene et leur expression clinique est extremement variable. Les formes a developpement purement intramusculaire peuvent etre trompeuses, et mimer une myosite focale. Il est essentiel d'en evoquer le diagnostic avant tout geste biopsique a l'aveugle, compte tenu du risque hemorragique.

Published
2006
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18. Percutaneous transluminal angioplasty in severe diabetic foot ischemia: outcomes and prognostic factors

Author

A. Hartemann-Heurtier, Philippe Cluzel, André Grimaldi, Sophie Jacqueminet, JL Golmard, R Izzillo, G. Ha Van, and F Koskas

Subjects
Male, endocrine system, medicine.medical_specialty, Percutaneous, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Ischemia, urologic and male genital diseases, Endocrinology, Angioplasty, Diabetes mellitus, otorhinolaryngologic diseases, Internal Medicine, medicine, Humans, Angioplasty, Balloon, Coronary, Foot Ulcer, Aged, Wound Healing, Univariate analysis, business.industry, Vascular disease, Patient Selection, Smoking, Angiography, General Medicine, Prognosis, medicine.disease, Diabetic foot, Diabetic Foot, Surgery, body regions, Diabetes Mellitus, Type 1, Treatment Outcome, surgical procedures, operative, Diabetic foot ulcer, Diabetes Mellitus, Type 2, Female, business
Abstract

Summary Objectives To evaluate the outcomes of severe ischemic diabetic foot ulcers for which percutaneous transluminal angioplasty (PTA) was considered as the first-line vascular procedure. Factors associated with successful PTA were sought. Research design and methods In 32 consecutive diabetic patients with foot ulcers and severe limb ischemia, PTA was performed if feasible; if not, primary bypass grafting was done when feasible. All patients were followed until healing or for at least one year. Patients with worsening ulcers after PTA underwent bypass grafting. Clinical and angiographic factors influencing outcomes after PTA were sought by univariate and multivariate analysis. Results PTA was done in 25 of the 32 (78%) patients, and considered clinically successful in 13 (52%). After 1 year, the healing rate was 70% and the limb salvage rate 90%. Successful PTA was significantly associated with a higher post-PTA transcutaneous oxygen pressure (P = 0.03) and presence of at least one patent pedal vessel (P = 0.03) in the univariate analysis; only a patent pedal vessel was significant in the multivariate analysis. Conclusion Primary PTA in diabetic patients with severe ischemic foot ulcers provides similar outcomes to usual results obtained in severe ischemia in absence of diabetes. The presence of one patent pedal vessel on arteriography before PTA is the best prognostic factor.

Published
2005
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19. Status of LUMINEU program to search for neutrinoless double beta decay of 100Mo with cryogenic ZnMoO4 scintillating bolometers

Author

F. Koskas, L. Torres, Claire A. Marrache-Kikuchi, A. A. Drillien, C. Nones, L. Devoyon, G. Pessina, B. Paul, X-F. Navick, Christian Enss, D.V. Poda, D. Gray, I.M. Ivanov, Matias Velázquez, V. Humbert, O. Strazzer, Loredana Gastaldo, A. Juillard, Achim Fleischmann, Luc Bergé, P. Magnier, M. Tenconi, Ya.V. Vasiliev, M. Gros, F.A. Danevich, Oudomsack Viraphong, Y. Penichot, E. Olivieri, D. M. Chernyak, O. Plantevin, E. P. Makarov, Vl.I. Tretyak, V.N. Shlegel, R. S. Boiko, M. Chapellier, S. Hervé, P. de Marcillac, S. Marnieros, A. Giuliani, T. Redon, L. Dumoulin, M. Mancuso, Martin Loidl, V.V. Kobychev, N. Coron, Matias Rodrigues, Kiev Institute for Nuclear Research (KINR), Ukrainian Academy of Sciences, Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Kirchhoff Institut für Physik, Universität Heidelberg [Heidelberg] = Heidelberg University, Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Nikolaev Institute of Inorganic Chemistry [Novosibirsk] (NIC), Siberian Branch of the Russian Academy of Sciences (SB RAS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire National Henri Becquerel (LNHB), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Istituto Nazionale di Fisica Nucleare (INFN), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1] (INFN), Istituto Nazionale di Fisica Nucleare, Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Osvaldo Civitarese, Ivan Stekl and Jouni Suhonen, ANR-12-BS05-0004,LUMINEU,Expérience souterraine avec détecteurs luminescents de molybdate de zinc pour l'étude de la masse et la nature des neutrinos(2012), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg], Università dell’Insubria, Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Istituto Nazionale di Fisica Nucleare [Milano] (INFN), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics::Instrumentation and Detectors, MEASURING INSTRUMENTS, 01 natural sciences, Particle identification, MOLYBDENUM 100, law.invention, Crystal, chemistry.chemical_compound, law, ELEMENTS, ANTICOINCIDENCE, REFRACTORY METAL COMPOUNDS, DOUBLE BETA DECAY, SIGNAL CONDITIONERS, Physics, TRANSITION ELEMENT COMPOUNDS, BOLOMETERS, EVEN-EVEN NUCLEI, TEMPERATURE GRADIENTS, ZINC COMPOUNDS, NUCLEAR DECAY, METALS, Neutrino, PARTICLE IDENTIFICATION, TRANSITION ELEMENTS, INTERMEDIATE MASS NUCLEI, PARTICLE DISCRIMINATION, Radioactive decay, REFRACTORY METALS, Zinc molybdate, PULSE CIRCUITS, PULSE SHAPERS, ENERGY RESOLUTION, MOLYBDATES, Scintillator, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear physics, MOLYBDENUM COMPOUNDS, MOLYBDENUM ISOTOPES, Double beta decay, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, BETA DECAY, STABLE ISOTOPES, NUCLEI, 010308 nuclear & particles physics, Bolometer, ELECTRONIC CIRCUITS, BETA-MINUS DECAY, CRYSTALS, OXYGEN COMPOUNDS, PHOSPHORS, chemistry, RESOLUTION, ISOTOPES, DECAY
Abstract

ISBN: 978-0-7354-1333-7; International audience; The LUMINEU program aims at performing a pilot experiment on 0ν2β decay of 100 Mo using radiopure ZnMoO4 crystals enriched in 100 Mo operated as cryogenic scintillating bolometers. Large volume ZnMoO4 crystal scintillators (∼ 0.3 kg) were developed and tested showing high performance in terms of radiopurity, energy resolution and α/β particle discrimination capability. Zinc molybdate crystal scintillators enriched in 100 Mo were grown for the first time by the low-thermal-gradient Czochralski technique with a high crystal yield and an acceptable level of enriched molybdenum irrecoverable losses. A background level of ∼ 0.5 counts/(yr keV ton) in the region of interest can be reached in a large detector array thanks to the excellent detectors radiopurity and particle discrimination capability, suppression of randomly coinciding events by pulse-shape analysis, and anticoincidence cut. These results pave the way to future sensitive searches based on the LUMINEU technology, capable of approaching and exploring the inverted hierarchy region of the neutrino mass pattern.

Published
2015
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20. Th1 and Th17 cytokines drive inflammation in Takayasu arteritis

Author

D, Saadoun, M, Garrido, C, Comarmond, A C, Desbois, F, Domont, L, Savey, B, Terrier, G, Geri, M, Rosenzwajg, D, Klatzmann, P, Fourret, P, Cluzel, L, Chiche, J, Gaudric, F, Koskas, and P, Cacoub

Subjects
Adult, Male, Adolescent, Giant Cell Arteritis, Interleukin-23, Severity of Illness Index, Interferon-gamma, Young Adult, Humans, Glucocorticoids, Aged, Aged, 80 and over, Inflammation, Interleukin-6, Tumor Necrosis Factor-alpha, Behcet Syndrome, Interleukin-17, Receptors, Interleukin-1, Middle Aged, Th1 Cells, Takayasu Arteritis, Case-Control Studies, Cytokines, Interleukin-2, Th17 Cells, Female
Abstract

Takayasu arteritis (TAK) is a large-vessel vasculitis that induces damage to the aorta and its branches. Glucocorticoids remain the gold standard of therapy for TAK. The nature of the T cells driving vascular inflammation and the effects of glucocorticoids on the systemic components of TAK are not understood. The aim of this study was to analyze T cell homeostasis and cytokine production in peripheral blood and inflammatory lesions of the aorta in patients with TAK.T cell homeostasis and cytokine production in peripheral blood and inflammatory lesions of the aorta were analyzed using Luminex analysis, flow cytometry, and immunohistochemical analysis. The study included 41 patients fulfilling the American College of Rheumatology 1990 criteria for the classification of TAK (17 patients with active TAK and 24 patients with disease in remission), 30 patients with giant cell arteritis and 39 patients with Behçet's disease (disease controls), and 20 age- and sex-matched healthy control subjects.We observed a marked increase in the expression of Th1 and Th17 cells, which correlated with TAK disease activity. The addition of serum from patients with active TAK to sorted CD4+ T cells from healthy donors in culture medium induced significant production of interferon-γ (IFNγ) and interleukin-17A (IL-17A). We demonstrated the presence of IFNγ-, IL-6-, and IL-17A-producing T cells in vascular inflammatory infiltrates in patients with TAK. Corticosteroid therapy was associated with decreased levels of circulating Th1 cytokines in corticosteroid-treated patients with TAK compared with steroid-free patients with TAK (for IL-2, mean ± SD 5,079 ± 5,300 versus 7,359 ± 3,197 pg/ml; for IFNγ, 2,592 ± 3,072 versus 8,393 ± 3,392 pg/ml; for tumor necrosis factor α, 847 ± 724 versus 1,491 ± 392 pg/ml). However, glucocorticoids had essentially no effect on the frequency of Th17 cytokines (IL-1 receptor, IL-17, and IL-23).The Th17 and Th1 pathways contribute to the systemic and vascular manifestations of TAK. Glucocorticoid treatment suppresses Th1 cytokines but spares Th17 cytokines in patients with TAK.

Published
2014

21. [Fibromuscular dysplasia]

Author

A C, Desbois, F, Koskas, and P, Cacoub

Subjects
Fibromuscular Dysplasia, Humans, Algorithms
Abstract

Fibromuscular dysplasia is a segmentary, non-atherosclerotic, non-inflammatory vascular disease that may result in stenosis, occlusion, aneurysms or dissection of medium arteries. Renal involvement is the most frequent location, described in 60-100% of patients. Renal stenosis can be asymptomatic or complicated with arterial hypertension or less frequently with renal insufficiency. Carotid and vertebral involvements are less frequent (10-35%). Surgical management of fibromuscular dysplasia is now less common because of the better efficacy of percutaneous transluminal angioplasty. Thus, histologic characteristics are no longer relevant prognostic criteria. Clinical features and outcome vary according to angiographic presentation (focal or multifocal disease), with an increased recovery rate of hypertension with focal lesions. In the presence of renal fibromuscular dysplasia, only symptomatic patients are revascularized (recent or resistant hypertension) or patients with asymmetric renal size or impaired renal function. Transluminal angioplasty is the first-line treatment except for patients with complex lesions or stenosis associated with aneurysm.

Published
2014

23. Lesiones ateromatosas oclusivas crónicas de la aorta y de los miembros inferiores

Author

É. Kieffer and F. Koskas

Abstract

Las lesiones oclusivas de la aorta y de los miembros inferiores son frecuentes en el curso de la aterosclerosis. Pueden permanecer asintomaticas durante mucho tiempo debido a diferentes mecanismos de suplencia. Usualmente se trata de una afeccion multivascular. Es en este campo en el que se han producido los mayores progresos de la terapeutica vascular en los ultimos anos. Las tecnicas quirurgicas de revascularizacion son ahora mucho mas seguras. Se han desarrollado nuevas tecnicas de revascularizacion intravascular, las cuales no compiten con las tecnicas quirurgicas sino que se les suman, permitiendo ampliar las indicaciones a un numero mas importante de pacientes [1] .

Published
2000
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24. Accelerated durability testing of metallic stents used as components for made-to-measure aortic endografts

Author

J. Molina, F. Koskas, J.-D. Singland, and B. Pain

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Biomedical Engineering, Measure (physics), Stent, Bioengineering, General Medicine, Computer Science Applications, Surgery, Human-Computer Interaction, Medicine, Durability testing, business, Biomedical engineering
Published
2008
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25. Anévrysme de l'aorte thoracique et spondylodiscite révélant une brucellose

Author

M Lévy-Soussan, H Blain, R. Laraki, J.C. Piette, Le Thi Huong Du-Boutin, P. Godeau, and F Koskas

Subjects
Spondylodiscitis, medicine.medical_specialty, biology, business.industry, Gastroenterology, Brucellosis, medicine.disease, biology.organism_classification, Surgery, Aortic aneurysm, Aneurysm, Internal Medicine, medicine, Discitis, Endocarditis, business, Spondylitis, Brucella melitensis
Abstract

Brucellosis, which decreased during the eighties in France, remains a public health problem in many Mediterranean countries. We report the case of a 65-year old patient native of Morocco, of thoracic aorta aneurysm and lumbar spondylodiscitis due to Brucella melitensis, revealed by haemoptysis and lumbar pains, with a favourable outcome after aortic graft resection, spinal plaster immobilization and specific lengthy antibiotic treatment. This case report is characterized by the absence of endocarditis or infectious focus near the aneurysm. Diagnosis of aneurysm and spondilitis due to Brucella melitensis is based on imaging and bacteriological and serological examination. Because of a clinical and biological intolerance for rifampicin and cotrimoxazole, this patient received ofloxacin-doxycyclin-streptomycin. We discuss antibiotic recommendations and stress the interest of the early diagnosis of complicated forms of brucellosis for a better prognosis.

Published
1997
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27. Quel Bazar !…

Author

E.-A. Hang-Korng, V. Zeller, P. Jacquenod, F. Koskas, A. Delcourt, J.-P. Brouland, N. Molinier, and J.-M. Ziza

Subjects
Gastroenterology, Internal Medicine
Published
2005
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28. Purification of molybdenum oxide, growth and characterization of medium size zinc molybdate crystals for the LUMINEU program

Author

V.Ya. Degoda, Christian Enss, Matias Velázquez, S.G. Nasonov, E. Olivieri, L. Gastaldo, M. Chapellier, V. V. Kobychev, P. Magnier, T. Redon, X. F. Navick, Oudomsack Viraphong, V.N. Shlegel, L. Devoyon, V.N. Zhdankov, O. Strazzer, S. Hervé, A. A. Drillien, Matias Rodrigues, S. Marnieros, Ya.P. Kogut, L. Torres, I.M. Ivanov, Y. Penichot, M. Gros, O. Plantevin, L. Dumoulin, G. Pessina, Rodolphe Decourt, Noël Coron, B. Paul, A. Giuliani, E. P. Makarov, Andreas Fleischmann, F. Koskas, Claire A. Marrache-Kikuchi, M. Tenconi, Laurent Bergé, Martin Loidl, R. S. Boiko, F.A. Danevich, Ya.V. Vasiliev, D. M. Chernyak, P. de Marcillac, M. Mancuso, C. Nones, D.V. Poda, and V.I. Tretyak

Subjects
Aqueous solution, Recrystallization (geology), Physics - Instrumentation and Detectors, Zinc molybdate, Physics, QC1-999, Inorganic chemistry, chemistry.chemical_element, FOS: Physical sciences, Crystal growth, Zinc, Instrumentation and Detectors (physics.ins-det), chemistry.chemical_compound, Physics and Astronomy (all), chemistry, Molybdenum, Sublimation (phase transition), Nuclear Experiment (nucl-ex), Luminescence, Nuclear Experiment
Abstract

The LUMINEU program aims at performing a pilot experiment on neutrinoless double beta decay of 100Mo using radiopure ZnMoO4 crystals operated as scintillating bolometers. Growth of high quality radiopure crystals is a complex task, since there are no commercially available molybdenum compounds with the required levels of purity and radioactive contamination. This paper discusses approaches to purify molybdenum and synthesize compound for high quality radiopure ZnMoO4 crystal growth. A combination of a double sublimation (with addition of zinc molybdate) with subsequent recrystallization in aqueous solutions (using zinc molybdate as a collector) was used. Zinc molybdate crystals up to 1.5 kg were grown by the low-thermal-gradient Czochralski technique, their optical, luminescent, diamagnetic, thermal and bolometric properties were tested., Comment: Contribution to Proc. of Int. Workshop on Radiopure Scintillators RPSCINT 2013, 17-20 September 2013, Kyiv, Ukraine; to be published in EPJ Web of Conferences; expected to be online in January 2014; 6 pages, 6 figures, and 3 tables

Published
2013
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29. Prise en charge des sténoses carotidiennes chez le coronarien

Author

F. Koskas

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Coronaropathie et carotidopathie atheromateuses ont une forte coprevalence. Pour etudier leur impact mutuel sur les resultats, un groupe de 2566 endarteriectomies carotidiennes (EC) effectuees de 2000 a 2012 a ete observe et retrospectivement clive en 1015 C+ selon la presence d’antecedents, de symptomes ou de signes coronaires et 1551 C– en l’absence de ceux-ci. Le contexte neurologique, la coronaropathie, les comorbidites, les gestes coronaires, les gestes associes et surtout les resultats ont ete compares dans les deux groupes. Le taux cumule de mortalite et morbidite neurologique postoperatoire (TCMM) etait de 1,7 % dans C+ contre 1,9 % dans C– pour les EC sans geste coronaire associe, de 1,9 % contre 1,2 % pour les EC isolees, de 2,5 % contre 4,5 % pour les EC avec geste coronaire prealable et de 6,1 % pour les 82 malades operes de facon combinee d’une EC et d’un pontage coronaire. Le taux actuariel moyen annuel d’evenement cardiovasculaire etait de 14,2 % dans C+ contre 7,5 % dans C–. En conclusion, la charge morbide de la carotidopathie chez le coronarien est assez faible si l’on utilise l’EC comme methode exclusive de revascularisation et dans un centre d’expertise. Le pronostic de ces polyarteriels carotidiens et coronariens est domine a court terme par les comorbidites, notamment aortiques. A long terme, ce pronostic est ecrase par la coronaropathie.

Published
2016
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30. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author

H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. D'Angelo, N. Baumann, S. Yorifuji, H. P. Endtz, M. A. Cassatella, R. A. C. Hughes, V. Golzi, A. Bittencourt, A. Ferreira, M. Sanson, C. Alper, M. Vermeulen, M. A. A. van Walderveen, E. Alexiou, C. H. Lucas, M. Fiorelli, Y. N. Debbink, R. Gil, S. Congia, T. Banerjee, J. M. Bouchard, A. N. Pinto, A. Ceballos-Baumann, G. Grollier, P. I. M. Schmitz, M. D. Catata, N. Lahat, N. S. Rao, P. Papathanasopoulos, J. Valls-Solé, D. Claus, G. Schroter, A. Castro, C. Videbaek, R. Martinez Dreke, A. D. Platts, M. Hermesl, A. C. PeÇanha-Martins, M. Cardoso Silva, P. Masnou, M. J. A. Tanner, Ch. Confavreux, B. Mishu, H. Rasmussen, L. Valenciano, Carlo Pozzilli, S. W. Li, V. Salzman, Y. Vashtang, Massimo Franceschi, M. Severo, G. Deuschl, S. Setien, G. Mariani, A. Protti, J. Castillo, M. J. B. Taphoorn, M. Frontali, I. Milonas, D. Decoq, J. A. Navarro, S. Castellvi-Pel, C. Ertikin, M. Urtasun, Y. Lajat, B. E. Kendall, E. Verdu, B. Gueguen, E. Boisen, R. Couderc, A Danek, JM Stevens, F. Nicoli, L. Feltri, M. L. Vazquez-Andre, J. A. Morgan-Hughes, L. D'Angelo, F. Y. Liew, L. F. Pascual, J. Patrignani Ochoa, Vittorio Martinelli, J. Cophignon, L. Zhang, S. Martin, J. F. Meder, H. C. Buschmann, L. Bertin, J. van Gijn, A. Barreiro, A. Cools, C. Leon, A. Berod, E. A. Anllo, E. Zanette, L. Petrov, R. Barona, B. Gallicchio, P. J. Cozzone, N. Diederich, G. Cancel, L. Schelosky, P. Orizaola, K. Yulug, S. Ozer, Valeria A. Sansone, B. Guiraud-Chaumeil, K. Voigt, P. Labauge, M. Eoli, J. Zhu, J. Aguirre, M. Ferrarini, B. Zyluk, E. Planas, A. Cadilha, C. Tortorella, H. Bismuth, C. E. Counsell, A. Laun, A. Ferlini, Rio J. Montalban, N. Biary, L. Becker, M. Fardeau, M. Poloni, V. M. S. de Bruin, C. Fornada, J. Barros, E. Ganzmann, E. Touze, D. Wallach, J. Peila, H. Fujimura, M. T. Iba-Zizen, G. Macchi, C. Villoslada, R. Gouider, Ph. Rondepierre, P. Grummich, P. Chiodi, C. Conte, M. Michels, P. Annunziata, G. Semana, C. Sommer, J. Vajsar, D. Zekin, J. Kulisevsky, David G. Munoz, B. Jacotot, M. Magoni, A. Luxen, T. Garcia-Silva, S. Di Cesare, Christophe Tzourio, M. Gomori, I. Picomell, L. Santoro, F. Villa, Giovanni Pennisi, T. Ribalta, J. M. Molto, L. Marzorati, P. Loiseau, F. Gemignani, A. Gironell, J. Wissel, A. Prusinski, F. Cailloux, P. Villanueva-Hemandez, P. Cozzone, T. Del Ser, J. Sans-Sabrafen, M. Zappia, P. W. A. Willems, G. Tchernia, D. Gardeur, R. Bauer, F. Palomo, H. Metz, S. Lamoureux, C. Chastang, I. Reinhard, A. Goldfarb, S. Harder, Jordi Río, C. Ozkara, E. Tekinsoy, P. Vontobell, J. De Recondo, M. Rabasa, L. Lacomblez, F. Boon, Dgt Thomas, V. Palma, Renato Mantegazza, A. Dervis, M. Nueckel, B. YalÇinerner, I. Duran, G. Dalla Volta, A. Zubimendi, J. Pinheiro, A. Marbini, Xavier Montalban, H. Wekerle, X. Pereira Monteino, F. Crespo, F. Koskas, N. Battistini, C. Ruiz, H. Offner, J. de Pommery, P. Kanovsky, J. Y. Barnett, J. Pardo, G. Tomei, R. Rene, H. M. Lokhorst, P. Thajeb, H. Bilgin, D. McGehee, R. Fahsold, L. Morgante, Katie Sidle, C. Delwaide, M. N. Diaye, P. H. Rice, A. Creange, C. Sabev, K. Stephan, K. WeilBenborn, G. Magnani, L. Grymonprez, F. Cardellach, M. Kaps, N. G. Meco, F. Vega, V. Bonifati, A. Desomer, M. Baldy-Moulinier, G. Kvale, F. J. Authier, B. Yegen, T. Ho, J. M. Rozet, E. A. Cabanis, L. Bruce, L. Ambrosoli, M. A. Petrella, M. Hernandez, P. Timmings, H. B. van der Worp, F. Mahieux, A. Urbano-Marquez, D. A. Krendel, A. A. Garcia, R. Divari, R. Michalowicz, M. R. Piedmonte, M. Bondavalli, M. Zanca, P. F. Ippel, Onofre Combarros, B. Tavitian, E. Hirsch, I. Anastasopoulos, A. Roses, A. Köhler, P. Vienna, V. Timmerman, P. Sergi, F. Cornelio, A. Di Pasquale, R. Verleger, S. Castellvirel, J. Proano, B. van Moll, F. Rubio, W. Hacke, I. Lavenu, L. Zetta, M. W. Tas, N. Bittmann, M. Bonamini, O. R. Hommes, V. Dousset, N. Afsar, S. Belal, R. R. Myers, J. Goes, Giuseppe Vita, E. Clementi, V. G. Karepov, M. Jueptner, A Vincent, P. Emmrich, Th. Heb, A. Caballo, J. Gallego, T. Mokrusch, C. Perla, L. Gebuhrer, O. 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Larumbe-Lobalde, G. de la Sierra, J. C. Alvarez-Cermeno, R. J. Seitz, P. L. Oey, L. Ptacek, A. M. J. Paans, A. Wirrwar, A. Schmied, J. Uilchez, H. Tounsi, D. Hipola, V. Avoledo, Y. Hirata, P. Vermersch, T. M. Aisonobe, J. Valls-SoIè, H. Staunton, J. Dichgans, R. Karabudak, I. Dones, G. Porta, E. Janssens, Maria Martinez, J. M. Fernandez-Real, R. Villagra, Y. Yoshino, C. Kabus, K. Schimrigk, I. Girard-Buttaz, F. Piccoli, F. Aichner, P. Zuchegna, S. M. Al Deeb, F. Bono, N. Busquets, A. Jobert, Patrizia Ciscato, M. Martin, L. Polman, S. Darbra, V. Le Cam-Duchez, F. Baldissera, B. Baykan-Kurt, D. Guez, M. Bratoeva, H. Matsui, M. Mila, H. Perron, L. Bjorge, G. Husby, Steven T. DeKosky, D. R. Cornblath, J. M. Gabriel, J. J. Poza, Y. Wu, A. Toscano, R. P. Kleyweg, J. Kuhnen, S. O. Confort-Gouny, A. Barcelo, A. M. Conti, C. Fiol, C. Steichen-Wiehn, J. Rodes, M. Cavenaile, C. Vedeler, M. Drlicek, C. Argentino, M. L. Peris, A. Cervello, A. Z. GinaÏ, S. Yancheva, D. Passingham, S. Aoba, D. L. 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Henderson, R. Massa, A. Cruz Martinez, U. Liska, F. Hecht, Ernst Holler, V. S. de Bruin, B. B. Sheitman, S. M. Bentzen, C. Bayindir, F. Pallesta, P. E. Roland, J. Parrilla, P. Zunker, L. F. Burchinskaya, G. Mellino, S. Ben Ayed, D. Bonneau, P. Nowacki, M. Goncalves, P. Riederer, N. Mavroudakis, J. Togores, L. Rozewicz, S. Robeck, Y. Perez Gilabert, L. Rampello, A. Rogopoulos, S. Martinez, F. Schildermans, C. Radder, P. B. Hedlund, J. Cambier, M. Aabed, G. D. Jackson, P. Gasparini, P. Santacruz, J. Vandevivere, H. Dural, A. Mantel, W. Dorndorf, N. Ediboglu, A. Lofgren, J. Bogousslavsky, P. Thierauf, L. Goullard, R. Maserati, B. Moering, M. Ryba, J. Serra, G. G. Govan, A. Pascual-Leone, S. Schaeffer, M. R. Rosenfeld, A. P. Correia, K. Ray Chaudhuri, L. Campbell, R. Spreafico, B. Genetet, A. M. Tantot, R. A. G. Hughes, J. A. Vidal, G. Erkol, J. Y. Delattre, B. Yaqub, B. K. Hecht, E. Mayayo, Ph. Scheltens, J. Corral, M. Calaf, L. Henderson, C. Y. Li, U. Bogdahn, R. Sanchez-Roy, M. 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Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg

Subjects
Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published
1994
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32. Ischemic Stroke due to Spontaneous Extracranial Vertebral Giant Aneurysm

Author

F. Koskas, G. Rancurel, E. Martin-Delassalle, M. Catala, and E. Kieffer

Subjects
medicine.medical_specialty, business.industry, Vertebral artery, medicine.disease, nervous system diseases, body regions, Aneurysm, Hematoma, Neurology, Spinal cord compression, Internal medicine, medicine.artery, Ischemic stroke, cardiovascular system, medicine, Cardiology, cardiovascular diseases, Neurology (clinical), Radiology, Arteritis, Vertebrobasilar insufficiency, Cardiology and Cardiovascular Medicine, business, Stroke
Abstract

Spontaneous extracranial vertebral aneurysms are very rare, presenting with varying clinical features such as laterocervical mass, cervicobrachial neuralgia, spinal cord compression or vertebrobasilar ischemic events. These aneurysms may be due to arteritis, parietal dissecting hematoma or atherosclerosis. We report a case of spontaneous atherosclerotic extracranial vertebral aneurysm characterized by vertebrobasilar transient ischemic attacks and stroke.

Published
1993
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33. [New ultra rapid test for detection of bacteria]

Author

P, Goldschmidt, T, Balloy, S, Degorge, D, Benallaoua, L, Batellier, F, Koskas, E, Borsali, and C, Chaumeil

Subjects
DNA, Bacterial, Time Factors, Bacteria, Humans, Real-Time Polymerase Chain Reaction
Abstract

Bacteriological testing is aimed to reduce the risk of transmission of infections. However, the detection of Bacteria by culture requires from 18hours to 14 days and may produce erroneous results for fastidious species. The goal of this work was to design and validate a new tool for bacterial testing.The test is based on the fast real-time PCR (frt PCR). The DNA extracted from samples containing internal controls are introduced into four tubes containing primers and probes for the frt PCR. The cycling program consists in 1×at 95°C for 10min and 45×(15s at 95°C, 8s) at 52°C and 10s at 72°C.The frt PCR detects 0,01 CFU/μl of Bacteria and identifies eight Genera without interferences from the environment or from fungi and with no need for melting curve analysis or additional sequencing.The frt PCR detects and quantifies Bacteria identifying and assessing the load of Staphylococci, Streptococci, Haemophilus, Pseudomonas, Enterobacteria, Acinetobacter, Propionibacteriacae and Corynebacteria.Cultures require at least 24hours but the new frt PCR reduces the time to 90minutes. Larger series of samples are necessary to confirm the usefulness of this new test for routine bacterial sterility controls.

Published
2009

34. Utilisation per et postopératoire d'une héparine de bas poids moléculaire en chirurgie vasculaire périphérique

Author

Pierre Viars, F. Koskas, S. Combe, Charles Marc Samama, Edouard Kieffer, M.P. Bridel, and S. Mouren

Subjects
Prothrombin time, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.drug_class, Anticoagulant, General Medicine, Thrombin time, Vascular surgery, medicine.disease, Thrombosis, Surgery, Anesthesiology and Pain Medicine, Blood vessel prosthesis, Anesthesia, medicine, business, Blood coagulation test, Partial thromboplastin time
Abstract

A pilot study has been conducted in ten consecutive patients undergoing femoro-popliteal reconstruction or distal vascular surgery under epidural anaesthesia. Immediately before arterial cross-clamping, enoxaparin (E) (75 anti-Xa IU.kg-1) was injected intravenously (i.v.). During surgery, washing of the saphenous or polytetrafluoroethylene (PTFE) graft has been performed using enoxaparin. Enoxaparin (75 anti-Xa IU.kg-1) was administered subcutaneously (S.C.) 8 hours after the i.v. injection, and then every 12 hours during 10 days. The patency of the vascular reconstruction and the side-effects of E administration were evaluated clinically before and during surgery, then by a daily clinical examination. Echo-Doppler and/or arteriography were also performed preoperatively and on the 10th postoperative day. Haematocrit, platelet count, activated partial thromboplastin time, prothrombin time, thrombin time, fibrinogen and anti-Xa activity were assessed. None of the patients developed venous or arterial thrombosis and all the by-pass grafts remained patient. Only one minor surgical bleeding occurred on the first post operative day, despite anti-Xa levels in the expected range. One patient developed minor haematomas at the injection site. No bleeding was observed. Further randomized studies comparing LMWH and UH are required in order to substantiate these preliminary clinical and biological findings.

Published
1990
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36. Mise en évidence des problèmes d’interfaces générés par la séparation du lien IHE-délivrance

Author

L. Goffinet, L. Boissy, J.-M. Etienne, Julia Gouvitsos, Elisabeth Durieux-Roussel, R. Beretti, A. Kihal, Laurent Barat, J. Leorza, I. Brisset, Caroline Izard, M. Poggi, M. Ventron, V. David, D. Bernard, Christine Clapasson, F. Koskas, M.-B. Montel, V. Ferrera-Tourenc, Isabelle Dettori, and B. Peres

Subjects
Biochemistry (medical), Clinical Biochemistry, Hematology
Abstract

Introduction Une organisation transfusionnelle associant 3 entites differentes, etablissement de soin (ES), site de delivrance (SDEL, qu’il soit ou non EFS) et laboratoire de biologie medicale (LBM) genere une augmentation des interfaces pour la gestion des identites, l’harmonisation de la connaissance des dossiers, la gestion des RAI positives et epreuve de compatibilite au laboratoire, la maitrise des delais et l’anticipation des besoins transfusionnels. Les analyses de risques demontrent que les etapes de rupture entre structures ou systemes d’information sont critiques. Dans ce type d’organisation la securisation de la delivrance necessite une integration des resultats d’immuno-hematologie (IH) informatises (format ERA) associee au rendu papier (CR). Methode Les anomalies rencontrees sont enregistrees informatiquement. La codification permet de distinguer : – absence de resultat IH en base ERA au moment du besoin transfusionnel (AM 121) ; – discordance d’identite entre prescription PSL et CR (AM 122) ; – discordance entre CR et fichier ERA (AM 123) ; – absence de transmission de CR (AM 124) ; – CR non conforme (incomplet, illisible, non signe par biologiste) (AM 125) ; – resultat discordant avec historique (AM 12). Resultat Sept des 13 sites sont concernes pour un total de 49 ES et de 12210 prescriptions de PSL entre septembre et decembre 2014. Au total 4,2 % des prescriptions font l’objet d’anomalies reparties dans le Tableau 1 . Conclusion La regularisation des anomalies genere soit une saisie manuelle (AM 121), soit un delai necessaire a la regularisation de la NC ou a l’envoi de prelevement de controle.

Published
2015
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37. [Evolution of the treatment of chronic post-traumatic aneurysms of the descending thoracic aorta: 30 years experience]

Author

E, Kieffer, L, Chiche, G, de Warnier Wailly, F, Lefevre, F, Koskas, and P, Cluzel

Subjects
Adult, Aged, 80 and over, Male, Postoperative Complications, Accidents, Humans, Female, Middle Aged, Aged, Aortic Aneurysm, Blood Vessel Prosthesis, Follow-Up Studies
Abstract

The authors present the early and late results of a series of 40 patients treated for chronic post-traumatic aneurysms of the descending thoracic aorta from 1975 to 2005. With the exception of a patient who died of an intra-pleural rupture before surgery, the patients were treated by aortotomy and prosthetic graft (N=17), aortotomy and direct suture (N=17) or endoprosthesis (N=5). The use of distal aortic perfusion in 22 patients enabled 17 direct sutures (77.3%) thanks to extensive mobilisation of the aortic arch. Endoprostheses have been used since 1997 in high surgical risk patients with severe comorbid conditions. There were no deaths, one transient paraparesia after simple aortic clamping, one reoperation for a haemothorax and four cases of dysphonia due to paralysis of the recurrent laryngeal nerve. Thirty-five patients (90%) were followed up for an average of 119.7 +/- 16.4 months. There were no clinical complications and the late morphological results were good in all cases with the exception of one type 1 endoprosthetic leak. The treatment of chronic post-traumatic aneurysms of the descending thoracic aorta gives excellent early and late results, justifying wide operative indications. The wish to avoid use of a prosthesis in young patients with a long life expectancy should give preference to conventional surgical techniques which, providing distal aortic perfusion is employed, allow direct suture of three quarters of cases. Endovascular treatment is reserved only for "poor surgical risks".

Published
2006

38. [How bizarre!...]

Author

E-A, Hang-Korng, V, Zeller, P, Jacquenod, F, Koskas, A, Delcourt, J-P, Brouland, N, Molinier, and J-M, Ziza

Subjects
Antibiotics, Antineoplastic, Doxorubicin, Hemangiosarcoma, Humans, Middle Aged, Tomography, X-Ray Computed, Aortography, Vascular Neoplasms, Aged
Published
2005

39. [Intramuscular vascular malformations as a differential diagnosis of focal myositis]

Author

A, Froissart, C, Pagnoux, F, Koskas, O, Dubourg, and P, Chérin

Subjects
Adult, Diagnosis, Differential, Male, Myositis, Biopsy, Blood Vessels, Humans, Muscle, Skeletal, Magnetic Resonance Imaging
Abstract

Focal myositis constitutes an original and rare pathological entity, characterized by a localized inflammation within skeletal muscle, presenting as a soft tissue painful tumefaction. Diagnosis requires histological confirmation because of its non-specific clinical feature and the numerous differential diagnoses.We report a 27 year-old man who presented with suggestive symptoms of focal myositis. MR imaging and echography were compatible with this diagnosis but also demonstrated the existence of a vascular component within the tumefaction. The diagnosis of a benign vascular malformation with intramuscular development was made by a surgically guided biopsy.Vascular malformations are histologically heterogeneous with extremely variable clinical expressions. When they develop within skeletal muscle, they may mimic focal myositis. Hence, their diagnosis has to be evoked before performing muscle biopsy, because of the potential hemorrhagic risk.

Published
2005

40. [Treatment for carotid stenosis: surgery, the reference]

Author

Jean Baptiste, Ricco, T, Lemonnier, F, Koskas, and C, Marchand

Subjects
Blood Vessel Prosthesis Implantation, Endarterectomy, Carotid, Recurrence, Angioplasty, Embolism, Humans, Carotid Stenosis
Abstract

THE CONTROVERSY: The indications for carotid revascularisation are clearly codified, but the surgical treatment is debatable. The angioplasty initially proposed for non-atheromatous stenosis or for high surgical risk patients is used by some as first-line therapy, although no benefit/risk ratio in its favour has been demonstrated. ARE THERE ANY BENEFITS WITH SURGICAL TREATMENT?: The efficacy of surgery in the treatment of atheromatous carotid stenosis has been demonstrated. The interest of angioplasty The advantages expected with carotid angioplasty are the absence of cervical incision and cervical nerve lesions, together with a reduction in the duration of hospitalisation and costs. Nevertheless, there are risks inherent to the femoral puncture and endovascular propagation from the femoral to the carotid artery. Till now, the published studies have not concluded in the superiority or equivalence of angioplasty versus surgery. FOR CERTAIN SUB-GROUPS: It has not been demonstrated but it is possible that a sub-group of high-risk patients could benefit from carotid angioplasty. There are no arguments for recommending angioplasty in the treatment of carotid re-stenosis following endarterectomy or for post-radiation stenosis. ANTI-EMBOLIC TREATMENT SHOULD BE FORESEEN: Carotid angioplasty is associated with embolus, the frequency of which is 8-fold greater than that observed after endarterectomy. The systematic use of cerebral protection is therefore recommended. TODAY: The treatment of reference of carotid stenosis remains endarterectomy conducted by vascular surgeons.

Published
2004

42. [Aortic dissections: recent endovascular therapeutic advances and current indications]

Author

F, Koskas, Ph, Cluzel, and E, Kieffer

Subjects
Aortic Dissection, Risk Factors, Humans, Aneurysm, Ruptured, Prognosis, Aortic Aneurysm, Blood Vessel Prosthesis
Abstract

Dissection is one of the most serious diseases of the aorta if only because of its potential for rupture, but also for other complications which may be fatal. Replacement with a prosthesis remains the treatment of reference as an emergency for proximal dissection and as an elective procedure for selected cases of distal dissection with complications. Despite steady progress in ancillary management (distal perfusion, circulatory arrest, cardiac, neurological and visceral protection) the operation remains a very invasive procedure. Aortic endoprostheses represent the therapeutic innovation of the decade for the treatment of aortic aneurysms and their use could be extended to dissections, at least for the most distal forms and to patients at very high surgical risk.

Published
2003

43. Outcome of severe diabetic foot ulcers after standardised management in a specialised unit

Author

A, Hartemann-Heurtier, G, Ha Van, J P, Danan, F, Koskas, S, Jacqueminet, J L, Golmard, and A, Grimaldi

Subjects
Adult, Aged, 80 and over, Male, Wound Healing, Diabetic Retinopathy, Time Factors, Middle Aged, Amputation, Surgical, Diabetic Foot, Diabetes Mellitus, Type 1, Treatment Outcome, Diabetes Mellitus, Type 2, Recurrence, Humans, Diabetic Nephropathies, Female, France, Hospital Units, Algorithms, Aged
Abstract

The primary objective was to evaluate the efficacy in terms of limb salvage and healing time of standardised multidisciplinary management for high-grade diabetic foot ulcers. The secondary objective was to retrospectively identify the factors that influenced time to healing.Over a 2-year period, 157 patients with diabetic foot ulcers were managed in our specialised unit using a standard treatment strategy; 118 were followed until healing or for at least 7 months (range, 7-29) after hospital discharge and form the basis for this study. Predetermined criteria were used to diagnose and manage the lesions. The number of major amputations and the time to healing were the main outcome measures. Univariable and multivariable analyses were done retrospectively to look for factors associated with time to healing.The limb salvage rate was 97.5% and the healing rate was 50% after 10 months and 70% after 16 months. Factors significantly associated with healing time were arterial disease without bypass surgery (p0.001) and renal replacement therapy (p0.05). Osteomyelitis, as managed in this study, did not increase the healing time (p0.6).In high-grade diabetic foot ulcers, standardised conservative management with second-line bone-sparing surgery, if needed, yields an acceptable limb salvage rate. With combined medical and surgical treatment, osteomyelitis is not a poor prognosis factor.

Published
2003

44. Aortoiliac Occlusive Disease with Claudication

Author

F. Koskas

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.drug_class, Occlusive disease, Aortoiliac occlusive disease, Thigh, medicine.disease, Magnetic resonance angiography, Duplex scanning, medicine.anatomical_structure, Sexual dysfunction, Internal medicine, medicine, Cardiology, medicine.symptom, Claudication, business, Antihypertensive drug
Abstract

A 63-year-old hypertensive heavy smoker presented in 1990 with a 24-month history of pain in the left calf and thigh occurring after walking 200 m at a “normal” pace. During the last 3 months, his claudication decreased to 100 m following the introduction of a beta-blocker antihypertensive drug. Pain ceased almost immediately after stopping walking and appeared again after the same stereotyped interval. There was no sexual dysfunction. Systemic enquiry was unremarkable.

Published
2003
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45. [Exploration of the origin of supra-aortic arterial trunk: can MR angiography with gadolinium injection replace digital angiography?]

Author

B, Randoux, B, Marro, N, Sourour, F, Koskas, D, Dormont, and C, Marsault

Subjects
Aged, 80 and over, Male, Angiography, Subclavian Artery, Arterial Occlusive Diseases, Gadolinium, Middle Aged, Vertebrobasilar Insufficiency, Humans, Carotid Stenosis, Female, Brachiocephalic Trunk, Magnetic Resonance Angiography, Aged
Abstract

Ostial stenosis of the craniocervical vessels are frequently associated with carotid stenosis. Consequently, exploration of the aortic arch is necessary prior to carotid endarterectomy. Contrast-enhanced MR angiography (gRMA) could replace digital substraction angiography (DSA). The goal of this work was to evaluate gRMA for the detection of ostial stenosis of the craniocervical vessels. Twenty two patients with carotid stenosis50% on sonography examination prospectively underwent gRMA and DSA. We analyzed the overall quality of each gRMA and the degree of ostial stenosis of the craniocervical vessels (innominate, left carotid, subclavian and vertebral arteries). Thirteen gRMA examination was considered as good quality and 8 as adequate for diagnosis. There was significant correlation between gRMA and DSA for degree of stenosis (k = 0.82, p0.0001). gRMA tends to overestimate degree of ostial stenosis, especially for vertebral arteries. We conclude that gRMA is a promising tool but cannot yet be used as a stand-alone procedure for the evaluation of ostial stenosis of the craniocervical vessels.

Published
2002

47. Purification of molybdenum, growth and characterization of medium volume ZnMoO4crystals for the LUMINEU program

Author

E. P. Makarov, V.N. Shlegel, V.Ya. Degoda, V.N. Zhdankov, L. Devoyon, G. Pessina, E. Olivieri, A. A. Drillien, C. Nones, Matias Velázquez, Matias Rodrigues, O. Plantevin, S.G. Nasonov, Oudomsack Viraphong, T. Redon, P. de Marcillac, M. Tenconi, F.A. Danevich, Martin Loidl, V.V. Kobychev, P. Magnier, Noël Coron, Rodolphe Decourt, M. Chapellier, V. Humbert, Y. Penichot, I.M. Ivanov, B. Paul, Loredana Gastaldo, X-F. Navick, O. Strazzer, M. Mancuso, M. Gros, S. Hervé, R. S. Boiko, Achim Fleischmann, A. Giuliani, Christian Enss, Luc Bergé, Ya.P. Kogut, S. Marnieros, F. Koskas, Claire A. Marrache-Kikuchi, D. V. Poda, Ya.V. Vasiliev, D. M. Chernyak, V. I. Tretyak, L. Dumoulin, and L. Torres

Subjects
gas and liquid scintillators), Materials science, Zinc molybdate, Radiochemistry, Refractory metals, Hybrid detectors, chemistry.chemical_element, Crystal growth, Zinc, Scintillator, scintillation and light emission processes (solid, chemistry.chemical_compound, Cryogenic detectors, Photoemission, Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators), chemistry, Molybdenum, Scintillators, Sublimation (phase transition), Luminescence, Instrumentation, Mathematical Physics
Abstract

The LUMINEU program aims at performing a pilot experiment on neutrinoless double beta decay of 100Mo using radiopure ZnMoO4 crystals operated as cryogenic scintillating bolometers. Growth of high quality radiopure crystals is a complex task, since there are no commercial molybdenum compounds available with the required level of purity and radioactive contamination. This paper discusses approaches to purify molybdenum and synthesize compounds for high quality radiopure ZnMoO4 crystal growth. A combination of a double sublimation (with addition of zinc molybdate) with subsequent recrystallization in aqueous solutions (using zinc molybdate as a collector) was used. Zinc molybdate crystals up to 1.5 kg were grown by the low-thermal-gradient Czochralski technique; their optical, luminescent, diamagnetic, thermal and bolometric properties were tested.

Published
2014
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50. [Endovascular treatment of aorto-iliac aneurysms. Made-to-measure endoprotheses increase the feasibility]

Author

F, Koskas, P, Cluzel, M, Bertrand, G, Godet, M H, Fléron, G, Boccara, M H, Fiévet, A, Liou, and E, Kieffer

Subjects
Iliac Aneurysm, Humans, Stents, Prosthesis Design, Stainless Steel, Aortic Aneurysm, Abdominal, Retrospective Studies
Abstract

The authors describe their experience of tailoring endoprostheses for endovascular treatment of aorto-iliac aneurysms with components available on the market. Between January 1996 and December 1999, 188 aorto-iliac aneurysms were treated by tailor-made endoprostheses using self-expanding Z stents made of stainless steel compiled with polyester ligatures and covered with standard commercially available polyester prostheses. These endoprostheses were implanted with an 18 to 24 Fr (usually 20 Fr) introducer and positioned by a surgical approach. This method allows construction of tubular, bifurcated, digressive or occlusive endoprostheses associated with an extra-anatomical bypass graft. It increased the number of endovascular procedures for aorto-iliac aneurysms in the authors' department. This number has been further increased by using endoprostheses with an uncovered proximal or distal stent for cases with particularly short or angled necks and by using hybrid endoprostheses with one or more extremities without a stent, allowing surgical suture of the anastomosis. The authors' results show that tailoring endoprostheses considerably increased the feasibility of endovascular treatment of aorto-iliac aneurysms, even in unselected patients whilst providing an effectiveness and safety to justify the continuation of this experience.

Published
2000

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