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Postoperative pain may lead to delayed mobilization, persisting pain, and psychosocial distress. There are no simple and reliable techniques for prediction of postoperative pain. This study was designed to evaluate if pain induced by venous cannulation or propofol injection can be used to predict postoperative pain.This prospective study included 180 patients scheduled for laparoscopic cholecystectomy. Pain intensity associated with peripheral venous cannulation and administration of propofol preoperatively and pain intensity, and use of opioid postoperatively was recorded.Patients scoring cannulation-induced pain intensity2.0 VAS units were given postoperative opioid more often (65% vs. 36%; P0.001), earlier (12 min vs. 90 min; P0.001), and in higher doses (4.8 mg vs. 0 mg; P0.001), and also reported higher levels of postoperative pain intensity (5.8 vs. 2.9 VAS units; P0.001). There were also significant (P0.01) correlations with postoperative pain intensity (rs = 0.24), time to opioid administration (rs = -0.26), and total dose of opioid (rs = 0.25). Propofol-induced pain intensity correlated significantly (P0.05) with postoperative pain intensity (rs = 0.19).Pain intensity associated with venous cannulation and propofol infusion can easily be evaluated at bedside before surgery without specific equipment or training. Patients scoring2.0 VAS units on venous cannulation were found to have 3.4 times higher risk of postoperative pain after laparoscopic cholecystectomy. Low pain intensity associated with venous cannulation and propofol infusion indicate lower risk of postoperative pain.