Author: "F Campi" - Searchworks@Jio Institute Digital Library Search Results

167 results on '"F Campi"'

1. A criticality assessment through user's routines in FLUKA

Author: F. Vanoni, E. Padovani, A. Porta, F. Campi, and R. Chebac
Subjects: Nuclear engineering. Atomic power, TK9001-9401
Abstract: In the present paper, a method to obtain the keff value using the FLUKA code is described. It took advantage of the chance to write user defined routines in the standard code. A new algorithm was implemented and tested on the simulation of a research nuclear reactor. Results pertaining to the estimation of keff and neutron fluence are in good agreement with the MCNP's ones.
Published: 2023
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2. Meningoencephalitis and intraventricular devices: when intravenous therapy is not enough

Author: L. Martini, D. De Rose, A. Santisi, C. Maddaloni, F. Pugnaloni, M. Calì, M.P. Ronchetti, F. Campi, A. Dotta, and C. Auriti
Subjects: Obstetrics and Gynecology
Published: 2023

3. Neurophysiological studies in infants with Vein of Galen aneurismatic malformation (VGAM): Bambino Gesù Children Hospital experience in the last two years

Author: M. Calì, S. Pro, P.G. Amante, S. Ronci, F. Pugnaloni, F. Calzolari, N. Chukhlantseva, L. Martini, C. Maddaloni, D.U. De Rose, M. Conti, P. De Liso, F. Campi, A. Dotta, and C. Gandolfo
Subjects: Obstetrics and Gynecology
Published: 2023

4. Genetic insight in vein of Galen aneurysmal malformation

Author: S. Ronci, F. Campi, D. Longo, P. Giliberti, E. Pisaneschi, S. Lozzi, S. Caoci, F. Pugnaloni, M. Calì, A. Di Pede, I. Capolupo, R. Vicario, M.C. Digilio, A. Novelli, A. Dotta, C. Gandolfo, and P. Bagolan
Subjects: Obstetrics and Gynecology
Published: 2023

5. Neurodevelopmental outcomes of infants with Vein of Galen aneurismatic malformation

Author: F. Pugnaloni, F. Campi, L. Raho, S. Ronci, M. Calì, I. Bersani, I. Savarese, F. Monaco, J. Rechichi, A. Romiti, F. Savignoni, C. De Marchis, A. Braguglia, C. Gandolfo, and A. Dotta
Subjects: Obstetrics and Gynecology
Published: 2023

6. Administering 25-hydroxyvitamin D3 in vitamin D-deficient young type 1A diabetic patients reduces reactivity against islet autoantigens

Author: Francesco Vierucci, Giovanni Federico, M De Donno, Giuseppe Saggese, Emioli Randazzo, Fabrizio Scatena, Marco Bugliani, B. Marchi, Chantal Mathieu, F. Campi, Piero Marchetti, and Daniele Focosi
Subjects: Male, medicine.medical_specialty, Adolescent, Interferon-g, Type 1A diabetes mellitus, Vitamin D, 25-Hydroxyvitamin D, ELISpot, Interferon-g, ELISpot, 25-Hydroxyvitamin D, Critical Care and Intensive Care Medicine, Autoantigens, Peripheral blood mononuclear cell, vitamin D deficiency, Interferon-gamma, chemistry.chemical_compound, Insulin-Secreting Cells, Internal medicine, medicine, Vitamin D and neurology, Humans, Vitamin D, Child, Calcifediol, Proinsulin, geography, Nutrition and Dietetics, geography.geographical_feature_category, C-Peptide, Glutamate Decarboxylase, C-peptide, business.industry, ELISPOT, Vitamin D Deficiency, Islet, medicine.disease, Diabetes Mellitus, Type 1, Type 1A diabetes mellitus, Endocrinology, chemistry, Leukocytes, Mononuclear, Female, business
Abstract: We investigated whether improving 25-hydroxyvitamin D status in young type 1A diabetic patients reduces reactivity of peripheral blood mononuclear cells against islet autoantigens and associates with beta-cell functional changes.Eight patients with 25-hydroxyvitamin D deficiency (20 ng/ml), out of 15 consecutive young type 1A diabetic subjects received 25-hydroxyvitamin D3 to achieve and maintain levels above 50 ng/ml for up to one year. Peripheral blood mononuclear cell reactivity (Interferon-γ spots) against beta-cell autoantigens (glutamic acid decarboxylase 65-kD isoform, proinsulin and tyrosine phosphatase-like protein IA-2) and C-peptide during mixed meal were assessed before and after 25-hydroxyvitamin D3 replenishment.Target 25-hydroxyvitamin D blood levels were safely reached and maintained. Peripheral blood mononuclear cell reactivity against glutamic acid decarboxylase 65-kD isoform (3.8 ± 4.0 vs. 45 ± 16) and proinsulin (3.5 ± 3.2 vs. 75 ± 51) decreased significantly (p 0.001 and p 0.02) upon 25-hydroxyvitamin D3 replenishment, which was correlated with 25-hydroxyvitamin D concentrations. C-peptide values remained stable after one year of treatment.Safely restored and maintained 25-hydroxyvitamin D levels associated with reduced peripheral blood mononuclear cell reactivity against beta-cell autoantigens with no significant decrease of beta-cell function in this cohort of patients.
Published: 2014

7. Pitcher Aging Affects Throwing Shoulder Biomechanics and Proprioception: The Italian Experience

Author: PEGREFFI, FRANCESCO, VITTORI, LEYDI NATALIA, FOSCHI, ELIA, MAIETTA LATESSA, PASQUALINO, PORCELLINI, GIUSEPPE, TENTONI, CLAUDIO, P. Paladini, F. Campi, A. Pellegrini, Meeusen, R., Duchateau, J., Roelands, B., Klass, M., De Geus, B., Baudry, S., Tsolakidis, E., F. Pegreffi, L. Vittori, E. Foschi, P. Latessa Maietta, P. Paladini, F. Campi, A. Pellegrini, G. Porcellini, and C. Tentoni
Subjects: education, Biomechanic, Baseball, Proprioception, human activities
Abstract: Introduction: Baseball is a sport increasingly practiced in Italy. The pitcher is at risk from repetitive stress on the dominant upper arm. Because of this, pitchers train far more on the dominant arm leading to asymptomatic biomechanical changes. The purpose of this study was to compare shoulder intra/extra rotational power and shoulder motor skill in young and senior athletes. Methods: Twenty right-hand healthy pitchers playing for at least four years were recruited : Group A (12±2yrs) and Group B (24±1yrs). Subjects with a history of shoulder dislocation, shoulder surgery or structural injuries to the shoulder complex were excluded from the study. Isokinetic tests (IT) were performed to evaluate intra/extra rotational power, and shoulder motor skill test (SMST) to evaluate proprioception. Results: Performing IT, we have found in both groups a significant higher external rotation compared to internal rotation in the throwing shoulder (TS), while in the contralateral shoulder (CS) the balance was preserved ( p
Published: 2012

8. The Dream Digital Signal Processor: Architecture, programming model and application mapping

Author: C. Mucci, F. Campi, L. Ciccarelli, PIZZOTTI, MATTEO, L. Vanzolini, M. Innocenti, ROSSI, DAVIDE, PERUGINI, LUCA, DE MARCO, TOMMASO, N. VOROS A. ROSTI M. HUEBNER, C. Mucci, D. Rossi, F. Campi, L. Ciccarelli, M. Pizzotti, L. Perugini, L. Vanzolini, T. De Marco, and M. Innocenti
Subjects: RECONFIGURABLE, PICOGA, MIX-GRAIN, GRIFFY-C, DATAPATH
Abstract: This chapter provides an overview of the DREAM digital signal processor. It discusses the programming model and the tool chain used to implement algorithm on the proposed architecture. It finally provides an application mapping example showing quantitative results.
Published: 2009

9. Treatment of clavicle fractures

Author: P, Paladini, A, Pellegrini, G, Merolla, F, Campi, and G, Porcellini
Subjects: Review
Abstract: Summary Clavicle fractures are very common injuries in adults (2–5%) and children (10–15%) (1) and represent the 44–66% of all shoulder fractures (2). Despite the high frequency the choice of proper treatment is still a challenge for the orthopedic surgeon. With this review we wants to focus the attention on the basic epidemiology, anatomy, classification, evaluation and management of surgical treatments in relationship with the gravity of injuries. Both conservative and surgical management are possible, and surgeons must choose the most appropriate management modality according to the biologic age, functional demands, and type of lesion. We performed a review of the English literature thought PubMed to produce an evidence-based review of current concept and management of clavicle fracture. We finished taking a comparison with our survey in order to underline our direct experience.
Published: 2012

10. Can capsular stretching change the scapulo-humeral coordination in baseball pitchers?

Author: Andrea Giovanni Cutti, Giuseppe Porcellini, F. Campi, Pietro Tonino, Paolo Paladini, Ilaria Parel, and Andrea Pellegrini
Subjects: Orthodontics, business.industry, Rehabilitation, Biophysics, Asymptomatic, Trunk, Sagittal plane, medicine.anatomical_structure, Scapula, medicine, Orthopedics and Sports Medicine, Humerus, medicine.symptom, business, Electromagnetic tracking, Range of motion, Throwing
Abstract: Main topics:Analysis of clinicalmovement data; Outcome after clinical intervention Introduction: Injury in the throwing shoulder of baseball pitchers andoverhead throwingathletes is common. Previous studies assessed scapular kinematics using electromagnetic tracking devices, demonstrating that patients with impingement have a reproducible pattern of shoulder dyskinesia [1]. In addition, they showeda correlationbetweenposterior shoulder tightness and forward scapular posture and confirmed that baseball players have more forward scapular posture of the dominant arm [2]. Possibly, capsular stretching programs might help restoring a normal scapulo-humeral coordinate. The aim of this study was to test this hypothesis by studying the scapular kinematics before and after a four weeks posterior stretching protocol in asymptomatic baseball pitchers. Patients/materials and methods: Eleven asymptomatic collegiate baseball pitchers were involved in the study. Pitchers were randomly separated in two groups: groupA (6 pitchers) underwent four weeks of a regimented therapy protocol; group B (5 pitchers) didnot received any treatment. Eachpitcherwas testedon two separate days: at the first day of the study (S1) and after four weeks (S2). The ISEO protocol was used to collect the kinematics of trunk, scapula and humerus [3] of both the throwing side (TS) and the contralateral (CS). The scapulo-humeral coordination (SHC) during humerus elevation in the sagittal (FlexExtension – FE) and scapular (AbAdduction – AA) plane was collected and then analyzed by means of coordinationplots, considering a commonhumeral Range of Motion (ROM) from 10◦ to 110◦, divided in steps of 5◦. SHC’s patterns of each subject were compared to age stratified reference bands (RB) computed from healthy subjects [4]. In order to verify if biologicalmodifications occurred, for each subject, firstly, the SHC’s pattern of TS and CS were compared to the age stratified reference bands (RB); secondly, the scapula ROM variations of TS between S1 and S2 were computed and compared to the Smallest Detectable Difference (SDD) of ISEO [5]. Results: The comparison of the SHC patterns with RBs showed that both TS (in S1 and S2) and CS of all subjects are within the correspondent reference bands, except one subject from group B, that presented alterations at TS only in S1. From the comparison of scapula ROM variations (S1–S2) with SDD values, group B showed that significant variations occurred only for one subject in MELA ROM during FE and AA and PA during AA. On the contrary 4 out of 6 pitchers that received the therapy showed clear signed of SHC alterations. Specifically, 4 subjects (67%) had variations in MELA during FE and 3 (50%) inMELAduringAA, and 1 subject in PAduring both FE and AA. These changes were towards the RB mean patterns, proving an improvement of the SHCs of TSs after the physical therapy. It is important to notice that variations in the subjects of group A occurred for both movements (FE and AA), strengthening the conclusion that the variation was real. Discussion and conclusions: This study highlights how posterior capsular stretching protocol can favour the maintenance of the SHC in asymptomatic baseball pitchers. Being a randomly and blinded study all pitchers of group A underwent the physical therapy protocol even if in S1 they had not presented an altered SHC compared to reference bands. The preliminary result of the study can indicate that, in order to prevent the pathologic cascade linked to these sports activities, this physical training protocol might become integral part of thenormal daily exercises of baseball pitchers and over-head athletes.
Published: 2015

11. A Case-Study on Multimedia Applications for the XiRisc Reconfigurable Processor

Author: C. Mucci, M. Bocchi, P. Gagliardi, L. Ciccarelli, A. Lodi, M. Toma, and F. Campi
Subjects: Flexibility (engineering), Reduced instruction set computing, Multimedia, business.industry, Computer science, Quality of service, Energy consumption, Application software, computer.software_genre, Computer architecture, Embedded system, business, Encoder, computer, Digital signal processing
Abstract: Embedded real-time multimedia applications pose several challenges in order to satisfy increasing quality of service (QoS) and energy consumption constraints, that are hardly matched by the capabilities of general-purpose standard processors. Reconfigurable processors, coupling the flexibility of software-programmable devices with the computational efficiency of application specific architectures, represent an appealing trade-off for next generation devices in the digital signal processing application domain. In this paper, we present a benchmarking application for the XiRisc reconfigurable processor, based on a public release of the MPEG-2 video encoder. The introduction of the reconfigurable logic gives a 5/spl times/ performance improvement and a 66% energy saving.
Published: 2006

12. XiSystem: a XiRisc-based SoC with a reconfigurable io module

Author: A. Cappelli, A. Lodi, M. Bocchi, C. Mucci, M. Innocenti, C. De Bartolomeis, L. Ciccarelli, R. Giansante, A. Deledda, F. Campi, M. Toma, and R. Guerrieri
Published: 2005

13. Radon data from different laboratoriesAn Italian Intercomparison

Author: F CAMPI, M CARESANA, M FERRARINI, L GARLATI, M PALERMO, R RUSCONI, L SALVATORI, and L VERDI
Published: 2005

14. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author: S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. Nauck, A Ekbom-Schnell, G Deferrari, Riccardo Schiaffini, S. Pampanelli, Khan Aka., David Hopkins, Maija Wessman, M Kamarinos, Noh J-H., O Ebisui, K McCarroll, Jeppe Sturis, Peter Nowotny, N Gorbenko, Åke Sjöholm, David G. Maggs, A E Halseth, B Cresci, A A Ortiz-Gress, A Korakovouni, O Matejkova, C E Mogensen, C J Lin, Ramon Gomis, H Seaman, C Granier, Yang C-H., F Assah, O Sanchez, Fausto Machicao, Peter G. Morris, Alberto Ortiz, A Giardinelli, D Bracaglia, A Gonzalo, S Pavlatos, Andreas Lechner, F Canovic, L Sjolind, Allan Vaag, Birgitte Bruun Nielsen, David A. Ziegler, Vito Lampasona, R Gershoni-Baruch, A. Dei Cas, H Renz, E Mena, Matthew Waltham, Kim D-M., H Levanen, D D Mick, Valentina Alexandrovna Peterkova, E Meskhishvili, Sarah Nutland, R Bustani, John R. Lindsay, M Christoforidou, A Abicht, E Harno, K Cyganek, A Fitchet, S Neelotpol, P Nikishin, P Serradas, J Hinrichsen, M Halvorson, M Chovatia, B Voet, Jinny Willis, E Parretti, M Haslbeck, M Wellard, L Teng, Julio Wainstein, J S Fischer, K. Lalic, D Roggenland, I Gich, R Anwar, Maurizio Cassader, D Serota, X J Li, R J Schotzinger, Vilmundur Gudnason, Björn Zethelius, S A Wootton, W Andrzejewski, R Rezsohazy, R Gao, T Klimentova, T Mazurek, I Bruckner, C Dohrmann, R E James, G daSilva Xavier, Kim S-Y., A Dorca, Stuart J. Pocock, Terri J. Allen, I Giovos, P B Parab, N H Andersen, P Fotinakis, Miriam Cnop, H Lee, Norbert Tennagels, Omorodola I. Abatan, F Ailett, I. Lager, D Manzella, H Hut, Larry A. Distiller, G Lip, Lim S-K., Rong Zhang, T Tsuno, Steen Knudsen, M. Bajardi, Manuel Benito, Dai Sugimoto, Melvin J. Prince, D W Dunstan, D Rankins, K A Majali, G Ozansoy, Isabella Russo, S Uçak, G Annuzzi, R Talar-Wojnarowska, K Lange, S Neugebauer-Baba, Campbell H. Thompson, Eric Renard, P. D. Mountjoy, Z Morrison, Elizabeth A. Davis, Franco Cavallo, C Corvaja, R Antuña, Craig John Currie, H Linnebjerg, He Y-L., A J Palmer, Mariola R. Chacón, H Malinska, M. Jones, R Lichnovská, K Mandes, Paolo Tessari, T Mokhort, A Laina, H. L. Y. Chan, I Schmidt, R Banks, Richard G. IJzerman, L Ksinantova, G Setti, H Vaudry, A Gallo, V Spallone, Chen J-W., Thomas Danne, A Chong, M Hallschmid, S Aczel, S Hulme, N Islam, M Hosoi, P M Ternan, P Di Bartolo, N Bishara, T Shibasaki, Martin A. Osterhoff, Im S-S., M Jecht, T Hamaguchi, S Mattera, K Ways, Elizabeth Northam, U Rajala, Reinhard W. Holl, L Yang, S Panaiotopoulos, K Horvath, R Kluge, Thora B. Bodvarsdottir, Y Dong, Irene Alemanno, C McDougall, Reimar W. Thomsen, M Campbell, W Rabl, John Öhrvik, Yuichiro Yamada, Paola Ungaro, W Benzer, Mike Sampson, Roberto Trevisan, R G Radu, Aas A-M., P E Lobo, Ricardo Scott, S M Son, Josephine M. Forbes, T A Hillier, K L Wyne, Louis L. Nguyen, J Farmer, M H Tan, Kwon H-S., J Yang, L Sandvik, Franco Folli, A K Jenum, M Nguyen, W Pratipanawatr, A L Frederiksen, Rebecca Smith, Lee H-J., A Schäfer, C Manuelli, G S Denver, T Vukovich, B Maceira, K Matsumoto, K. Chokkalingam, Nurcan Üçeyler, P Modi, Timothy M. Morgan, S Mertens, B M Singh, Michaela Riedl, K Iso, C Cucurullo, G. F. Bottazzo, M Calvani, K Hur, J Wetzels, Kazuhiro Takahashi, Y Aso, H Stammer, M G Masding, Fitsum Guebre-Egziabher, J L González-Sánchez, L Armstrong, Alberto Maran, Peter G.F. Swift, S S Popovic, J Starczynski, E Vitacolonna, Luigi Laviola, R W Gelling, Marina Cardellini, D Barilla, Rosa de Diego Martínez, W H Landschulz, Anne Mette Rosenfalck, R K Wong, Kevin E. Schneider, K Peros, Giuseppe Nanni, F Zhang, I Rákóczi, T Iburi, M Nakhjavani, X Q Zhang, S Tournis, Per Lav Madsen, Graham A. Hitman, A. Tura, K Laubner, N D Kostic, Lawrence M. Dolan, R. Sinha Roy, J A Wagner, J. Tuomilehto, J Hauptman, M Abdel-Ghany, D Lacombe, Toralph Ruge, Johannes A Maassen, Triantafyllos Didangelos, K Sasaki, I Argüelles, Klaus Levin, C Popow, Emanuel Christ, R Chetty, L Baillet-Blanco, Jo-Ann Salmon, T Mine, James L. Trevaskis, I Franke, J Gorski, E A Andrianova, A Dayan, A Caballero, Aleksandra Gilis-Januszewska, M Yasujima, Z Kasalová, C.D.A. Stehouwer, F. K. Gorus, G A Nichols, A Glowania, David P. Strachan, P Fredlund, N. F. da Silva, P Reboldi, M Sausbier, K H Groenier, G Stuccio, N Guttman, K R Ahmed, A D Ristic, T Kapellen, J Coutcher, Aldo V. Greco, Oswald Wagner, A Zagayko, Maria Alevizaki, B B Zhang, W F Ferris, Jenny Fredriksson, Lois Jovanovic, J Hänninen, R De Giglio, Kazuo Yagui, O Potterat, P Hamliton, R E Scranton, B Mankovsky, A Stylianou, B Fellström, Abdel-Wahab Yha., M Kitagawa, Katherine L. Baldock, F R Johnson, F Baigts, S D'Addato, F J Sanz, A Mistry, S D Wise, T Pratipanawatr, U R Fölsch, James R.C. Parkinson, Claudia Sommer, C Park, F E Griffiths, M L Martí, R Demirtunc, S Taniguchi, J Lundkvist, T Siegmund, Juan Sztajzel, C Dienesch, F Baumgartner, L Scalone, T M Mckolanis, K Otake, Ullrik Pedersen-Bjergaard, T M Vriesendorp, Michael B. Wheeler, Henry Schmitt, Peter Hovind, S Lange, Stephane Roze, L. Van Gaal, B Klaproth, Anthony E. Civitarese, D Eckland, A Dagar, D F Hopkins, Kari Stefansson, C Gonzalez-Yanes, B Meyboom-de Jong, D. J. Betteridge, K Buhling, M Crepaldi, Ana M. Wägner, L Renna, L Volpe, R McBride, V Corbo, E O Brennesvik, R P Hayes, R Abdollahnia, G Viviani, C F Liew, Francisco Pérez-Bravo, Jeffrey Baron, Brian M. Frier, H H Samira, D Szentendrei, K. J. Schjoedt, W K Waldhäusl, D Gniuli, D Zou, G Tschank, V Urbančič, A L Nolan, Albertini J-P., J Malcomson, M Larbig, C Cheyssac, K Aurich, C M Kesson, S Heller, Maija E. Miettinen, R F Luco, Adrian J. Cameron, Luigi Mattiello, Z. Metelko, X E Zhang, M Parramón, I. G. 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Jensen, A D'Avanzo, J Monaghan, K P Yeo, Guivarch P-H., B Bauduceau, D Weghuber, P Tatti, J Ybarra, S Gwozdziewiczová, E Gasparini, B Saltin, Charlotte Granhall, Howard Leventhal, R Marin, M Tumiati, Cicero Afg., L Csémy, B Berger, S Mikros, D Dall'Asta, M Shahmanesh, Y G Vasiljev, F Potthoff, H S Randeva, G De Berardis, J O Logan, K Warncke, P Uitterlinden, E Rehring, K Gilmore, K Shankhdhar, V V Bojko, M Vahatalo, E A Korolyova, D Wiemann, P G Lankisch, D Hendrie, F Galtier, M Rybarczyk, Gisela Dahlquist, N N Rudovich, G Stein, A Liebl, F Tan, A Westerlund, S Gronemann, I Franklin, Jonathan A. Prince, Peter Arner, E Skliros, T. Sparre, M Vigas, Maddalena Trombetta, L. Bjerre Knudsen, A C Sima, I Dubroca, Alastair Gray, I Weets, R Ferraresi, Schauer Ujw., E. Leinonen, S Corazza, Jonathan Levy, P K Prakash, R Guzder, S. Barnhill, John Blangero, J Herreros, G. de Vries, Cheng Ptw., A Macías-Batista, K. 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Hansen, T Watanabe, Gang Hu, Malik Rja., T Kennedy-Martin, Ulla M Smidt, J.M. Dekker, A A Fisher, H Liu, R E Pratley, B Sun, C Fledelius, J F Raposo, R Langham, Ahn S-Y., B R Waterhouse, Shaoping Deng, W Ricart, S V Melnichenko, Henrike Sell, M. Tomalino, N Takeda, Paola Massucco, A Harlan, W Henrich, C D Byrne, R Junik, Khalid Hussain, D Pop Gorceva, Torben Hansen, C Ritterath, K Ogawa, D V Phan, Bradley S Metcalf, Robb E. Moses, Juan P. Frias, Hitoshi Ishii, C Brisard, P Wolkow, H H Maurer, Ingo Rustenbeck, Juris J. Meier, Octavian Savu, S D Lin, V B Bregovski, A Fox, S Cicala, M. Koenen, L Vignati, O de Divitiis, Constantin Ionescu-Tirgoviste, Kilian Rittig, J Song, Riccardo Candido, F Cohen-Boulakia, U Shankhdhar, P Jahan, Antonio Tiengo, E Liepinsh, C Álvarez, Sigurd Lenzen, James E. 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Tryfinopoulou, K, Melidonis, A, Nikolopoulou, C, Harley, K, Ryder, R, De, P, Vannieuwenhoven, F, Rossing, K, Oliver, N, Goldschmeding, R, Jacobsen, P, Tan, F, Liew, S, Mukherjee, J, Lim, P, Fröjdö, S, Sjölind, L, Parkkonen, M, Mäkinen, V, Tikellis, C, Nieuwenhoven, F, Macisaac, R, Tsalamandris, C, Mcneil, K, Panaiotopoulos, S, Smith, T, Ho, M, Matthews, P, Jerums, G, Hut, H, Van Den Meiracker, A, Nakhjavani, M, Behjati, J, Esteghamati, A, Esfahanian, F, Aghamohamadzadeh, N, Abbasi, M, Kohnert, K, Zander, E, Krabbe, S, Stehouwer, C, Schalkwijk, C, Krarup Hansen, T, Teppo, A, Ebeling, P, Abdella, N, Mojiminiyi, O, Al Dahi, W, Al Mohammedi, H, Al Jebely, S, Neugebauer baba, S, Baba, T, Ohashi, H, Nakajima, S, Hesselmann, C, Watanabe, T, Nargis, M, Zaid, R, Voronko, O, Tchugunova, L, Vikulova, O, Nosikov, V, Liu, L, Zheng, T, Li, M, Zhang, R, Xiang, K, Hadjadj, S, Jeunemaitre, X, Vervoort, G, Veldman, B, Berden, J, Wetzels, J, Singh, B, Holland, M, Baskar, V, Oh, J, Seo, J, Choi, K, Baik, S, Choi, D, Kim, N, Matsumoto, S, Suetsugu, M, Matsutomo, R, Pisarczyk wiza, D, Banaszak, A, Wysocki, H, Usui, H, Shikata, K, Okada, S, Ogawa, D, Yozai, K, Kido, Y, Nagase, R, Ohga, S, Tone, A, Sasaki, M, Wada, J, Unno, Y, Horiuchi, S, Mclennan, S, Kamarinos, M, Waltham, M, Dy, V, Yue, D, Zdychova, J, Komers, R, Cresci, B, Giannini, S, Manuelli, C, Giunti, S, Pinach, S, Ianni Palarchio, A, Arnaldi, L, Vittone, F, Camussi, G, Cavallo Perin, P, Gruden, G, Marshall, S, Jones, S, White, K, Brizzi, M, Dentelli, P, Rosso, A, Calvi, C, Gambino, R, Cassader, M, Salvidio, G, Deferrari, G, Pegoraro, L, Pagano, G, Cavallo perin, P, Oates, R, Ellery, C, Beebe, D, Coutcher, J, Qian, Y, Lowe, V, Appleton, T, Raunig, D, O'Neil, S, Mylari, B, Amazonas, R, Fujita, A, Doi, A, Matsuno, S, Okamoto, K, Matsumoto, E, Furuta, H, Nishi, M, Tsuno, T, Taniguchi, H, Bessho, H, Wasén, E, Isoaho, R, Mattila, K, Vahlberg, T, Kivelä, S, Irjala, K, Rigalleau, V, Lasseur, C, Perlemoine, C, Barthes, N, Raffaitin, C, Chauveau, P, Combe, C, Baillet blanco, L, Beauvieux, M, Gin, H, Heinrich, S, Steiner, T, Ott, U, Holdass, H, Fellström, B, Jardine, A, Staffler, B, Logan, J, Gimpelewicz, C, Stanciu, C, Pena, C, Serafinceanu, C, González posada, J, Hernández, D, Pérez tamajó, L, Ló, A, Herná Alarcó, M, Meneses, M, Barsotti, M, Rizzo, G, Schmauss, S, Havrdova, T, Saudek, F, Boucek, P, Adamec, M, Invitti, C, Gilardini, L, Parati, G, Mazzilli, G, Pontiggia, B, Sartorio, A, Lutgers, H, Groenier, K, Zasadzinska, G, Saryusz wolska, M, Kurktschiev, D, Majdrakova, I, Varbanova, T, Todorova, B, Bajo martinez, A, Bernal, E, Sanchez, O, Ugalde canitrot, A, Sanchez largo, E, Coca robinot, D, Fabregate, R, Calbacho, M, Marquez, J, Saban ruiz, J, Penesova, A, Cizmarova, E, Blazicek, P, De Jongh, R, Serné, E, Ijzerman, R, De Vries, G, Andersen, N, Knudsen, S, Helleberg, K, Mogensen, C, Waluś, M, Idzior waluś, B, Sztefko, K, Cieślik, G, Fedak, D, Wozniakiewicz, E, Lin, S, Guo, M, Lin, C, Liu, X, Francisco, M, Rodriguez rosas, H, Peiró martinez, I, Macías batista, A, Harte, A, Rodriguez cuenca, S, Valsamakis, G, Chetty, R, Anderson, L, Roca, P, Matyka, K, Lasalle, J, Hershon, K, Berman, L, Gibson, E, Gillen, D, Maroni, J, Simmons, D, Hiukka, A, Forder, P, Leinonen, E, Hilden, H, Fruchart, J, Keech, A, Farnier, M, Freeman, M, Macdonell, G, Perevozskaya, I, Mitchel, Y, Gumbiner, B, Didangelos, T, Athyros, V, Mikhailidis, D, Papageorgiou, A, Bouloukos, V, Pehlivanidis, A, Symeonidis, A, Elisaf, M, Mckenney, J, Insull, W, Lewin, A, Maccubbin, D, Kush, D, Schuster, H, Barter, P, Stender, S, Bonnet, J, Morrell, J, Watkins, C, Kallend, D, Stalenhoef, A, Ballantyne, C, Murin, J, Tonstad, S, Rose, H, Wilpshaar, W, Jenkins, A, Karschimkus, C, Dragicevic, G, Rowley, K, Wolthers, T, Best, J, Voet, B, Murdoch, S, Marcovina, S, Brunzell, J, Caparevic, Z, Kostic, N, Ilic, S, Sartore, G, Piarulli, F, Cantaro, S, Reitano, R, Fiore, C, Marin, R, Bassan, S, Manzato, E, Fedele, D, Solini, A, Santini, E, Thornalley, P, Babaei jadidi, R, Karachalias, N, Kupich, C, Ahmed, N, Fowler, A, Baker, A, Starczynski, J, O'Hare, P, Szepietowska, B, Szelachowska, M, Puch, U, Glebocka, A, Quinn, D, Mcternan, C, Bonser, R, Idzior walus, B, Woźniakiewicz, E, Dimitriou, K, Apostolou, O, Kontela, E, Devangelio, E, Gould, E, Serri, O, Roussin, A, Buithieu, J, Mamputu, J, Renier, G, Giordanetti, S, De Amici, E, Poggi, G, Turpini, C, Fratino, P, Garzaniti, A, Banu, I, Paries, J, Roman, G, Negrean, M, Bala, C, Nita, C, Kistorp, C, Gustafsson, F, Chong, A, Lip, G, Galatius, S, Ari, N, Sahilli, M, Ceylan isık, A, Ozansoy, G, Karasu yilmaz, C, Matteucci, E, Rosada, J, Pallini, M, Evangelista, I, Cassetti, G, Giusti, C, Giampietro, O, Capaldo, B, Galderisi, M, Cicala, S, Turco, A, Imbroinise, A, Nosso, G, D'Errico, A, De Divitiis, O, Klimontov, V, Korolyova, E, Jeltova, L, Bondar, I, Tarkun, I, Arslan, B, Canturk, Z, Tarkun, P, Agacdiken, A, Komsuoglu, B, Méneveau, N, Pierre justin, E, Alsayed, M, Sabbah, R, Paulin, S, Marcu, S, Tauveron, I, Zimmermann, C, Schiele, F, Seronde, M, Vautrin, P, Lusson, J, Thieblot, P, Bernard, Y, Mistry, A, Pye, M, Peovska, I, Maksimovic Pavlovic, J, Vavlukis, M, Pop Gorceva, D, Bosevski, M, Scognamiglio, R, Negut, C, De Kreutzenberg, S, Madonna, R, De Caterina, R, Willerson, J, Geng, Y, Vahsen, S, Ledwig, D, Ramrath, S, Frantz, S, Schmidt, I, Calvillo, L, Dienesch, C, Elbing, I, Bischoff, H, Ertl, G, Bauersachs, J, Davydov, A, Mkrtum'Yan, A, Baranova, L, Ikeda, Y, Suehiro, T, Osaki, F, Ota, K, Arii, K, Kumon, Y, Hashimoto, K, Doney, A, Morris, A, Palmer, C, Byun, S, Doo, H, Pagnin, E, Calo, L, Fadini, G, Kubaszek, A, Chai, S, Chai, Q, Rasmussen, L, Ledet, T, Wogensen, L, Lengyel, C, Varró, A, Virág, L, Magyar, J, Bíró, T, Jost, N, Skoumal, R, Nánási, P, Tóth, M, Horkay, F, Papp, J, Zacharopoulou, O, Athanaselis, S, Tsokos, N, Doupis, J, Psallas, M, Cokkinos, D, Pavlatos, S, Liatis, S, Akhobadze, T, Dzneladze, L, Samarguliani, I, Taskiran, M, Rasmussen, V, Jensen, G, Fisher, A, Petrovsky, N, Srikusalanukul, W, Budge, M, Trifunovic zamaklar, D, Zivkovic, M, Jelic, V, Vukomanovic, G, Ristic, A, Seferovic, P, Costa, J, Duarte, S, Manley, S, Sailesh, S, Venkataraman, A, Haider, Y, Groza, I, Oprean, M, Ardelean, A, Morosanu, A, Darkow, T, Vanderplas, A, Mamas, M, Mcelduff, P, Burns, J, Edwards, R, Fitchet, A, Young, R, Gibson, J, Lichiardopol, R, Niculescu, N, Totora, A, Pencea, C, Tomescu, I, Cinteza, M, Manicardi, V, Coscelli, C, Navazio, A, Catellani, E, Michelini, M, Dall'Asta, D, Guberti, A, Piazza, A, Gasparini, E, Pantaleoni, M, Guiducci, U, Manari, A, Sejil, S, Janand delenne, B, Avierinos, J, Habib, G, Labastie, N, Vague, P, Lassmann vague, V, Luźniak, P, Tatoń, J, Wojciechowska Luźniak, A, Zairis, M, Lyras, A, Patsourakos, N, Tsirimbis, V, Foussas, S, Lupón, J, Urrutia, A, Herreros, J, González, B, Coll, R, Altimir, S, Prats, M, Valle, V, Abreu padí, C, Rábago, G, Ivanova, L, Brasacchio, D, Harno, E, Keenan, A, Li, H, Lu, Z, Ke, L, Liu, H, Jeong, I, Chae, M, Choi, M, Yoo, H, Kim, C, Yun, M, Na, M, Kang, Y, Kong, O, Son, S, Kim, I, Tanaka, N, Hosoi, M, Matsuyama, Y, Fukumoto, M, Yamakita, T, Yoshioka, K, Ishii, T, Sato, T, Fujii, S, Aoki, T, Shibata, T, Mizutani, N, Suzuki, J, Fowelin, J, Samuelsson, P, Brandrup wogsen, G, Okumura, K, Tokmakova, A, Staroverova, D, Antcieferov, M, Shutichina, I, Kuntchevich, G, Vriesendorp, T, Morélis, Q, Legemate, D, Schaper, F, Mainas, E, Gkioulmpasanis, I, Panagiotou, I, Vassilikos, G, Skorda, L, Sidira, M, Christoforidou, M, Alaveras, A, Artikis, V, Evdemon, E, Lechleitner, M, Koch, T, Ebenbichler, C, Sturm, W, Moretti, L, Moruzzo, D, Boldrini, E, Pandolfo, C, Kameyama, M, Iwasa, R, Cho, M, Nam, J, Huh, K, Kaplar, M, Paragh, G, Erdei, A, Csongradi, E, Garai, I, Varga, J, Galuska, L, Udvardy, M, Higa, M, Kaneko, Y, Hiroi, N, Koziarska, D, Nowacki, P, Majkowska, L, Luzniak, P, Wojciechowska luźniak, A, Tushuizen, M, Nieuwland, R, Snoeck, D, Sturk, A, Diamant, M, Aguiar, L, Bahia, L, Villela, N, Laflor, C, Conde, C, Bottino, D, Dorigo, D, Bouskela, E, Pu, S, Luo, Z, Lam, K, Dan, Q, Xu, A, Shen, J, Cheng, K, Xu, J, Thamer, C, Stefan, N, Haap, M, Heller, E, Tschritter, O, De Prado, A, Ortiz, A, Ybarra, J, Gich, I, Pou, J, Ehren, M, Roggenland, D, Reinsen, B, Klein, H, Rittig, K, Stock, J, Kocher, B, Balletshofer, B, Shon, H, Chung, D, Nakatani, Y, Matsuhisa, M, Kaneto, H, Hatazaki, M, Yoshiuchi, K, Katakami, N, Kawamori, D, Ohtoshi, K, Sakamoto, K, Matsuoka, T, Ozawa, K, Ogawa, S, Hori, M, Yamasaki, Y, Zitouni, K, Harry, D, Nourooz zadeh, J, Earle, K, Olesen, P, Franco, L, Corvaja, C, Semplicini, A, Ceylan işık, A, Arı, N, Rösen, P, Lee, I, Park, K, Jung, E, Shin, D, Jo, S, Obuobie, K, Prakash, P, Hanna, F, Lazarus, J, Varadhan, L, Gurushankar, J, James, D, Sheikh, S, Gaede, P, Zou, D, Vilarrasa, N, Perez maraver, M, Mena, E, Perez, D, Setti, G, Buckingham, R, Urbančič, V, Stefanovska, A, Bernjak, A, Ažman juvan, K, Kocijančič, A, Glowania, A, Filters, T, Fosmark, D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
Subjects: 0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published: 2004

15. Thermodynamically distinct high and low affinity states of the A(1) adenosine receptor induced by G protein coupling and guanine nucleotide ligation states of G proteins

Author: A, Lorenzen, L, Guerra, F, Campi, H, Lang, U, Schwabe, and P A, Borea
Subjects: Receptors, Purinergic P1, Brain, In Vitro Techniques, Ligands, Guanosine Diphosphate, Guanine Nucleotides, Rats, Prosencephalon, Purinergic P1 Receptor Antagonists, GTP-Binding Proteins, Xanthines, Papers, Purinergic P1 Receptor Agonists, Animals, Thermodynamics
Abstract: The influence of the receptor-G protein coupling state and the guanine nucleotide ligation state of the G protein on the binding mechanism of A(1) adenosine receptor ligands has been investigated in [(3)H]-1,3-dipropyl-8-cyclopentylxanthine ([(3)H]-DPCPX) binding studies in rat brain membranes. Thermodynamic parameters of binding of A(1) adenosine receptor ligands of different intrinsic activities were determined in the absence or presence of GDP and compared to the binding mechanism after receptor-G protein uncoupling. In agreement with previous studies, it was found that xanthine and non-xanthine antagonists showed an enthalpy- or enthalpy- and entropy-driven binding mechanism under all conditions. In contrast to antagonists, the binding mechanism of agonists was strongly affected by the G protein coupling state or the absence or presence of guanine nucleotides. Binding of full and partial agonists to the high-affinity state of the A(1) receptor was entropy-driven in the absence of GDP, and a good correlation between intrinsic activities and the contribution of entropy was observed. In the absence of GDP, binding of full and partial agonists and antagonists to the high affinity state of the receptor was thermodynamically discriminated. In contrast, no such discrimination was found in the presence of GDP. The binding mechanism of agonists to the low-affinity state of the receptor was identical to that of antagonists only after uncoupling of the receptor from G proteins by pretreatment with N-ethylmaleimide or guanosine-5'-(gamma-thio)-triphosphate (GTPgammaS). These results indicate the existence of two thermodynamically distinct high- and low-affinity states of the A(1) adenosine receptor.
Published: 2000

16. Endocrine-disrupting agents on healthy human tissues

Author: G, Paganetto, F, Campi, K, Varani, A, Piffanelli, G, Giovannini, and P A, Borea
Subjects: Male, Estradiol, Receptors, Retinoic Acid, Uterus, Phthalic Acids, Prostate, Tretinoin, Metribolone, Tritium, Binding, Competitive, Receptors, Estrogen, Pregnenediones, Receptors, Androgen, Culture Techniques, Androgen Receptor Antagonists, Humans, Environmental Pollutants, Female, Receptors, Progesterone, Testosterone Congeners
Abstract: A vast number of substances have been suggested as possibly contributing to perturbation of the endocrine system. Several have been tested with different approaches ranging from yeast expression system of human oestrogenic receptors to human breast cancer cells assays. Surprisingly, no inhibition-binding experiments to steroid receptors on healthy human tissue have been performed so far. Our study provides inhibition binding experiments to oestrogens, progesterone, testosterone and retinoic acid receptors in prostate and uterine human tissue of organochlorine pesticides, phthalate esters, oestrogenic constituents derived from plants and phenol derivates. Affinities of significant extent of phthalates on oestrogenic, progestinic and androgenic receptors have not been detected. As for retinoic acid receptors, mono(2-ethylexyl)phthalate provokes a notable reduction of the binding of the tritiated retinoic acid, phtalic acid ethyl-n-butyl ester and 4-octylphenol show an affinity comparable to that of isoflavonoid genistein, whereas 4-nonylphenol reduces the binding of retinoic acid in prostate.
Published: 2000

17. Hemiarthroplasty of the shoulder. Clinical experience in 18 cases treated by the Neer monoblock prosthesis

Author: G, Porcellini, F, Campi, G, Baccarani, and R, Galassi
Subjects: Male, Shoulder Joint, Joint Prosthesis, Humans, Female, Middle Aged, Prosthesis Design, Aged
Abstract: The authors report the results of 18 hemiarthroplasties of the shoulder performed between 1990 and 1994 using the Neer II monoblock prosthesis, emphasizing the technical and surgical problems encountered. The patients treated numbered 13 for traumatic pathology (acute fractures: 7; sequelae of fracture of the proximal epiphysis of the humerus: 6), and 5 for degenerative lesions (arthrosis: 3; rheumatoid arthritis: 2). An evaluation of the results was based on the Constant method and isokinetic testing. Results based on follow-up obtained after 2 to 6 years were satisfactory in 83% of the cases.
Published: 1999

18. Conservative surgical approach versus non-surgical management for diabetic neuropathic foot ulcers: a randomized trial

Author: A, Piaggesi, E, Schipani, F, Campi, M, Romanelli, F, Baccetti, C, Arvia, and R, Navalesi
Subjects: Wound Healing, Diabetes Mellitus, Type 1, Time Factors, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Foot, Patient Satisfaction, Recurrence, Humans, Middle Aged, Patient Acceptance of Health Care, Diabetic Foot, Aged
Abstract: To test the efficacy of surgical treatment of non-infected neuropathic foot ulcers compared to conventional non-surgical management, a group of diabetic outpatients attending our diabetic foot clinic were studied. All patients who came to the clinic for the first time from January to December 1995 inclusive with an uncomplicated neuropathic ulcer were randomized into two groups. Group A received conservative treatment, consisting of relief of weight-bearing, regular dressings; group B underwent surgical excision, eventual debridement or removal of bone segments underlying the lesion and surgical closure. Healing rate, healing time, prevalence of infection, relapse during a 6-month period following intervention and subjective discomfort were assessed. Twenty-four ulcers in 21 patients were treated in group A (17 Type 2 DM/3 Type 1 DM, age 63.24 +/- 13.46 yr, duration of diabetes 18.2 +/- 8.41 yr, HbA1c 9.5 +/- 3.8%) and 22 ulcers in 21 patients in group B (19 Type 2 DM/2 Type 1 DM, age 65.53 +/- 9.87yr, duration of diabetes 16.84 +/- 10.61 yr; HbA1c 8.9 +/- 2.2%). Healing rate was lower (79.2% = 19/24 ulcers) in group A than in group B (95.5% = 21/22 ulcers; p0.05), and healing time was longer (128.9 +/- 86.60 days vs 46.73 +/- 38.94 days; p0.001). Infective complications occurred significantly more often in group A patients (3/24, 12.5% vs 1/22, 4.5%; p0.05), as did relapses of ulcerations (8 vs 3; p0.01). There were only two minor perioperative complications in group B patients. Patients reported a higher degree of satisfaction in group B (p0.01) as well as lower discomfort (p0.05) and restrictions (p0.05). Thus surgical treatment of neuropathic foot ulcers in diabetic patients proved to be an effective approach compared to conventional treatment in terms of healing time, complications, and relapses, and can be safely performed in an outpatient setting.
Published: 1998

19. Inhibition of endosomal acidification in normal cells mimics the derangements of cellular insulin and insulin-receptor metabolism observed in non-insulin-dependent diabetes mellitus

Author: F. Campi, R. Maggiorelli, E. Merola, P Cecchetti, A.M. Ciccarone, L. Benzi, A. Nardone, G. Di Cianni, and R. Navalesi
Subjects: medicine.medical_specialty, Receptor complex, Time Factors, endocrine system diseases, Endosome, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Endosomes, Biology, Monocytes, Cohort Studies, Iodine Radioisotopes, Endocrinology, Reference Values, Internal medicine, Diabetes mellitus, medicine, Humans, Insulin, Monensin, Receptor, Pancreatic hormone, Chromatography, High Pressure Liquid, Ionophores, nutritional and metabolic diseases, Middle Aged, medicine.disease, Endocytosis, Receptor, Insulin, Insulin receptor, Endocytic vesicle, Diabetes Mellitus, Type 2, biology.protein, Protein Binding
Abstract: Dissociation of the insulin-insulin receptor complex plays a crucial role in the processing of both insulin and the insulin receptor, and the acidification of endocytic vesicles may be the mechanism by which internalized insulin is dissociated from its receptor and properly sorted and processed. Internalized insulin-insulin receptor complexes are abnormally processed in cells from patients with non-insulin-dependent diabetes mellitus (NIDDM). Accordingly, to further investigate the mechanisms of the derangements observed in NIDDM cells, we examined the effects of the ionophore monensin, which inhibits endosomal acidification, on the cellular processing of insulin and insulin receptor in monocytes from control subjects (n = 12) and NIDDM patients (n = 14). This study confirms that monocytes from NIDDM patients, compared with cells from normal controls, had reduced binding (P.01), internalization (P.01), and degradation (P.01) of insulin. In addition, the release of intracellular radioactivity was slower (P.01), and recycling of the insulin receptor was inhibited (P.01). Moreover, these defects were associated with a significant (P.01) decrease of dissociation of the internalized insulin-insulin receptor complex. In cells from normal controls, incubation with monensin decreased insulin binding (P.01), but not insulin internalization. High-performance liquid chromatography (HPLC) analysis of intracellular radioactivity showed that after monensin intracellular intact insulin significantly increased (P.01), thus suggesting a decrease of intracellular insulin degradation. Moreover, insulin receptor recycling was completely disrupted. All of these derangements were associated with a significant decrease (P.01) of dissociation of insulin-insulin receptor complexes. On the contrary, in diabetic monocytes, monensin had no significant additional effect on NIDDM-linked alterations. Comparison of the results obtained in cells from NIDDM patients to those found in monensin-treated normal cells demonstrates that NIDDM and monensin gave rise to a superimposable impairment of dissociation of the intracellular insulin-insulin receptor complex, associated with similar abnormal sorting and processing of insulin and its receptor. The only defect present in NIDDM cells but not in monensin-treated cells is the decrease of insulin internalization, which thus seems independent of the action of monensin on the processing of internalized insulin-insulin receptor complex. These results suggest that the impairment of dissociation of the insulin-insulin receptor complex may play a crucial role in the subsequent altered processing of insulin and insulin receptor. Moreover, they raise the question as to a possible similar alteration of the same intracellular mechanism by NIDDM and monensin, and point out that the derangements found in cells from NIDDM patients could be localized within the endosomal apparatus and consist mainly of a defective acidification of its interior.
Published: 1997

20. Isokinetic testing to evaluate patients submitted to surgery for the treatment of surgical lesion of the rotator cuff

Author: G, Porcellini, G, Baccarani, F, Campi, and R, Galassi
Subjects: Male, Rupture, Time Factors, Middle Aged, Aged, Female, Follow-Up Studies, Humans, Isometric Contraction, Rotator Cuff, Shoulder Impingement Syndrome, Muscle Contraction, Rotator Cuff Injuries
Abstract: A total of 100 cases surgically treated for rupture of the extra-rotator cuff were evaluated by isokinetic testing. Results were evaluated after a period of time ranging from 1 to 4 years, based on the Constant system, defining the type of lesion of the cuff based on the Snyder classification system, and measuring strength postsurgery using isokinetic testing after 3 and 6 months, and 1 year. Isokinetic testing made it possible to accurately evaluate which patients are capable of obtaining better recovery, and how much time is required for physiotherapy for postoperative rehabilitation, also allowing for correction on an individual basis of any muscular imbalance.
Published: 1996

21. Calcific tendinitis of the rotator cuff with trochiteal osteolysis. A rare clinical radiologic complication

Author: G, Porcellini, F, Campi, and M, Battaglino
Subjects: Adult, Radiography, Rotator Cuff, Shoulder Impingement Syndrome, Calcinosis, Female, Humans, Middle Aged, Osteolysis, Tendinopathy
Abstract: Among cases of calcific tendinitis that are unresponsive to any type of non-surgical treatment, the authors report 3 cases, out of a total of 32 submitted to surgery, that presented with an osteolytic cavity filled with calcium salts in the insertional region of the supraspinous tendon. These patients presented with pain that they had been experiencing for an average of 4 years, with acute recurrent episodes. When this pathology can be determined radiographically, early surgery is recommended, considering that any type of non-surgical treatment is destined to fail.
Published: 1996

22. [Rotator cuff rupture in the shoulder impingement syndrome. Echography and arthrography: 2 diagnostic methods compared]

Author: G, Porcellini, F, Campi, F, de Nicolò, S, Vottari, C, Valbonesi, and E, Arcangeli
Subjects: Aged, 80 and over, Male, Rupture, Rupture, Spontaneous, Aged, Arthrography, Evaluation Studies as Topic, Female, Humans, Joint Diseases, Middle Aged, Pain, Rotator Cuff, Shoulder Joint, Syndrome, Ultrasonography, Spontaneous, 80 and over
Abstract: After briefly reviewing the shoulder impingement syndrome, the authors investigate the role of two diagnostic imaging methods, i.e., ultrasonography (US) and arthrography, in demonstrating the typical features of this condition. Over a 15 months' period, 190 patients suffering from shoulder pain were examined with arthrography; 50 of them subsequently underwent acromion plastic surgery and rotator cuff stitching. This study was aimed at comparing US and arthrographic results, applying classifiable criteria to make the most accurate diagnosis of rotator cuff tears. The lack of visibility of the rotator cuff at US was the major and clearest sign of tear (100% of cases). The association between cuff thinning and hypo/hyperechoic damaged focal areas was another major sign (in 76.19% of complete tears and in 14.28% of incomplete tears). Hyperechoic focal areas alone proved to be a false-positive finding in 5 cases, while in 11 of 19 cases normal US patterns were a false-negative finding; in 3 cases other conditions were diagnosed. To conclude, the value of US is emphasized in the screening of the painful shoulder and the use of arthrography is suggested when both clinical tests and US fail to yield enough information for a diagnosis to be made.
Published: 1994

23. Tears of the rotator cuff associated with neurologic disorders: a description of two cases

Author: G, Porcellini, F, Campi, and E, Brunetti
Subjects: Aged, 80 and over, Diagnosis, Differential, Aged, Brachial Plexus Neuritis, Humans, Male, Rupture, Rotator Cuff Injuries, Diagnosis, Differential, 80 and over
Abstract: Based on their clinical experience with the two cases described, the authors analyze the association between surgically treatable tear of the rotator cuff and neurologic pathology. A semeiologic sign is emphasized, which may be of help in differential diagnosis involving isolated lesion of the rotator cuff. Furthermore, after a review of the literature, the authors express doubts as to the type of surgical treatment to be carried out.
Published: 1994

24. Poster Session III, July 15th 2010 —- Abstracts Upper limb functional evaluation on baseball pitchers through a portable 3D tracking system based on inertial sensors

Author: AG Cutti, P Garofalo, F. Campi, Andrea Pellegrini, P Palladini, Pietro Tonino, and G Porcellini
Subjects: musculoskeletal diseases, Engineering, medicine.medical_specialty, Kinematics, Population, Baseball, Session (web analytics), Physical medicine and rehabilitation, Scapula, Inertial measurement unit, Injury prevention, medicine, Pitching, education, Engineering(all), Simulation, Functional evaluation, education.field_of_study, business.industry, Work (physics), General Medicine, Inertial, medicine.anatomical_structure, Upper limb, business
Abstract: Introduction During baseball pitching, the shoulder is constantly exposed to micro-traumatic stress and shoulder injury can potentially end a career. Recently, an upper limb functional evaluation protocol based on MTx (Xsens Technologies B.V., the Netherlands) was developed by INAIL Prostheses Centre (Italy). The aim of this work was to apply the protocol on baseball pitchers, looking for indications to prevent possible shoulder injuries. Methods Three baseball pitchers participated in the study. All the pitchers signed informed consent. The scapulo-humeral rhythm (SHR) and the humero-thoracic external rotation (EXT) were evaluated before and after 60 pitches. The same evaluations were repeated 24 hours later. For each subject, the ROM and pattern of SHR and EXT during each session of measurement (S1, S2, S3) were compared to each other. Results Subject 1 presented consistent ROM in all the degrees of freedom and movements examined, indicating no particular shoulder alterations due to the pitching. Subject 2 presented alterations occurring between S1 and S2, and an improvement in the SHR after 24 hours. Subject 3 showed an improvement between S2 and S3 but evident compensation strategies were maintained after 24 hours. Conclusions Larger population of pitchers are required to confirm the capability of the system to discriminate among different alterations and/or injuries occurring in the players. Moreover, the measurement of the real-time pitching can augment the information about the behavior of the shoulder during training, in terms of performance, repeatability of the movement and injury prevention.
Published: 2010

25. D-3 Upper Limb Functional Evaluation on Baseball Pitchers Through a Portable 3D Tracking System Based on Inertial Sensors

Author: Pietro Garofalo, Andrea Pellegrini, Pietro Tonino, F. Campi, Paolo Paladini, Ilaria Parel, Andrea Giovanni Cutti, and Giuseppe Porcellini
Subjects: Functional evaluation, medicine.anatomical_structure, Computer science, Inertial measurement unit, 3d tracking, Rehabilitation, Biomedical Engineering, Biophysics, medicine, Upper limb, Orthopedics and Sports Medicine, Simulation
Published: 2010

26. Increased Plasma Manganese Superoxide Dismutase (MnSOD) Levels in Neonates with Severe IRDS

Author: F Campi, Paola Papoff, L Ligi, Marcello Orzalesi, F Cerroni, P Colarizi, F Ficuccilli, F Laurenti, A Manna, and G Seganti
Subjects: medicine.medical_specialty, Endocrinology, Chemistry, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Manganese Superoxide Dismutase
Published: 1998

27. PP-30

Author: Napoleone Prandini, R. Reverberi, G. Massini, Leo Massari, Luciano Feggi, F. Campi, A. Schiavi, and L. Lodi
Subjects: medicine.diagnostic_test, business.industry, medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Nuclear medicine, business, Scintigraphy
Published: 1997

28. Towards XUV-pump XUV-probe experiments with attosecond pulses at the Lund Laser Centre.

Author: S Maclot, H Coudert-Alteirac, F Campi, P Rudawski, L Rading, B Manschwetus, C M Heyl, M Miranda, B Farkas, F Brizuela, B Kim, A L'Huillier, and P Johnsson
Published: 2015
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29. Gli organi nel mondo antico: I secolo a.C. - III d.C

Author: CASTALDO, DANIELA, F. Campi (a cura di), and Castaldo, Daniela
Subjects: Organo, hydraulis
Published: 2016

30. The MORPHEUS Heterogeneous Dynamically Reconfigurable Platform

Author: Michael Huebner, Sami Yehia, Rolf Ernst, Philippe Bonnot, Philippe Millet, Wolfram Putzke-Roeming, Fabio Campi, Davide Rossi, Arnaud Grasset, Alberto Rosti, Henning Sahlbach, Nikolaos S. Voros, A. Grasset, P. Millet, P. Bonnot, S. Yehia, W. Putzke-Roeming, F. Campi, A. Rosti, M. Huebner, N. S. Voro, and D. Rossi
Subjects: Computer science, 02 engineering and technology, 01 natural sciences, System-on-Chip, Theoretical Computer Science, Reconfigurable architecture, 0103 physical sciences, Memory architecture, 0202 electrical engineering, electronic engineering, information engineering, Reference architecture, Embedded system, 010302 applied physics, business.industry, Reconfigurable computing, 020202 computer hardware & architecture, Data flow diagram, Dynamic reconfiguration, Applications architecture, Data architecture, Granularity, business, Space-based architecture, Software, Information Systems
Abstract: Reconfigurable computing offers a wide range of low cost and efficient solutions for embedded systems. The proper choice of the reconfigurable device, the granularity of its processing elements and its memory architecture highly depend on the type of application and their data flow. Existing solutions either offer fine grain FPGAs, which rely on a hardware synthesis flow and offer the maximum degree of flexibility, or coarser grain solutions, which are usually more suitable for a particular type of data flow and applications. In this paper, we present the MORPHEUS architecture, a versatile reconfigurable heterogeneous System-on-Chip targeting streaming applications. The presented architecture exploits different reconfigurable technologies at several computation granularities that efficiently address the different applications needs. In order to efficiently exploit the presented architecture, we implemented a complete software solution to map C applications to the reconfigurable architecture. In this paper, we describe the complete toolset and provide concrete use cases of the architecture.
Published: 2010

31. Design space exploration of an open-source, IP-reusable, scalable floating-point engine for embedded applications

Author: Fabio Campi, Tapani Ahonen, J. Kylliainen, Fabio Garzia, Claudio Brunelli, Jari Nurmi, Claudio Mucci, Davide Rossi, C. Brunelli, F. Campi, C. Mucci, D. Rossi, T. Ahonen, J. Kylliäinen, F. Garzia, and J. Nurmi
Subjects: Coprocessor, Floating point, business.industry, Design space exploration, Computer science, FLOATING POINT, FPU, Parallel computing, COPROCESSOR, Logic synthesis, Hardware and Architecture, Embedded system, VHDL, Datapath, Stratix, Hardware_ARITHMETICANDLOGICSTRUCTURES, business, Field-programmable gate array, EMBEDDED, computer, Software, computer.programming_language
Abstract: This paper describes an open-source and highly scalable floating-point unit (FPU) for embedded systems. Our FPU is fast and efficient, due to the high parallelism of its architecture: the functional units inside the datapath can operate in parallel and independently from each other. A comparison between different versions of the FPU has been made to highlight how performance scales accordingly. Logic synthesis results show that our FPU requires 105 Kgates and runs at 400 MHz on a low-power 90 nm std-cells low-power technology, and requires 20 K Logic Elements running at 67 MHz of an Altera Stratix FPGA. The proposed FPU is supported by a software tool suite which compiles programs written using the C/C++ language. A set of DSP and 3D graphics algorithms have been benchmarked, showing that using our FPU the amount of clock cycles required to perform each algorithm is one order of magnitude smaller than what is required by its corresponding software implementation.
Published: 2008

32. Application Space Exploration of a Heterogeneous Run-Time Configurable Digital Signal Processor

Author: Roberto Guerrieri, Davide Rossi, Henning Sahlbach, Fabio Campi, W. Putzke-Roming, Claudio Mucci, Sean Whitty, Simone Spolzino, Luca Vanzolini, Rolf Ernst, D. Rossi, C. Mucci, F. Campi, S. Spolzino, L. Vanzolini, H. Sahlbach, S. Whitty, R. Ernst, W. Putzke-Röming, and R. Guerrieri
Subjects: Digital signal processor, Signal processing, BINARIZATION CGRA, business.industry, Computer science, Dynamic frequency scaling, Control reconfiguration, Image processing, Reconfigurable computing, Space exploration, ADVANCED ENCRYPTION STANDARD (AES), CMOS, Hardware and Architecture, Embedded system, DIGITAL SIGNAL PROCESSOR (DSP), APPLICATION-SPECIFIC SIGNAL PROCESSORS (ASSP), Electrical and Electronic Engineering, business, CYCLIC REDUNDANCY CHECK (CRC), Software, Computer hardware, Efficient energy use
Abstract: This paper describes the application space exploration of a heterogeneous digital signal processor with dynamic reconfiguration capabilities. The device is built around three reconfigurable engines featuring different flavours and computation granularities that make it suitable for a wide range of signal processing application domains such as video coding, image processing, telecommunications, and cryptography. Performance of signal processing applications is evaluated from measurements performed on a CMOS 90 nm prototype. In order to characterize the application space of the processor, performance is compared with state-of-the-art devices, taking programmability, computational capabilities, and energy efficiency as the main metrics. The device exploits performance and energy efficiency significantly more than general purpose processors, while still maintaining a user-friendly programming approach that mainly relies on software-oriented languages. The device is able to achieve 1.2 to 15 GOPS with an energy efficiency from 2 to 50 GOPS/W when running the selected applications.
Published: 2013

33. A Heterogeneous Digital Signal Processor for Dynamically Reconﬁgurable Computing

Author: ROSSI, DAVIDE, CAMPI, FABIO, GUERRIERI, ROBERTO, S. Spolzino, S. Pucillo, D. Rossi, F. Campi, S. Spolzino, S. Pucillo, and R. Guerrieri
Subjects: LOCALLY SYNCHRONOUS, DIGITAL SIGNAL PROCESSORS, GLOBALLY ASYNCHRONOUS, NETWORK-ON-CHIP, RECONFIGURABLE ARCHITECTURES
Abstract: This paper describes a System on Chip implementation of a reconﬁgurable digital signal processor. The device is suitable for execution of a wide range of applications exploiting a balanced mix of heterogeneous reconﬁgurable fabrics merged together by a ﬂexible and efﬁcient communication infrastructure based on a 64-bit Network On Chip. The SoC combines a ﬁne grain embedded FPGA, a mid grain conﬁgurable processor and a coarse grain reconﬁgurable array. An ARM processor featuring a resident operating system is the SoC supervisor, managing communication, synchronization and reconﬁguration mechanisms. This computational model enables the programmer to manage the high level synchronization and global data of complex signal processing applications through the ARM processor, while allocating most critical computational kernels to the most suitable reconﬁgurable engines. The SoC has been fabricated in 90-nm technology, the die area being 110mm2
Published: 2010

34. RTL-to-layout implementation of an embedded coarse grained architecture for dynamically reconfigurable computing in systems-on-chip

Author: Ralf Konig, Fabio Campi, E. Schuler, M. Juttner, Moritz Neukirchner, D. Picard, Michael Hübner, A. Deledda, Roberto Guerrieri, Jürgen Becker, M. Dreschmann, A. Pasini, Davide Rossi, STMicroelectronics [Agrate Brianza] (ST-AGRATE), Institut für Technik der Informationsverarbeitung (ITIV), Karlsruher Institut für Technologie (KIT), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (UMR 3192) (Lab-STICC), Université européenne de Bretagne - European University of Brittany (UEB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Chemnitz University of Technology / Technische Universität Chemnitz, PACT XPP Technologies, Advanced Research Center on Electronic Systems for Information and Communication Technologies E. De Castro [Bologna] (ARCES), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), IEEE Press, F. Campi, R. Konig, M. Dreschmann, M. Neukirchner, D. Picard, M. Juttner, E. Schuler, A. Deledda, D. Rossi, A. Pasini, M. Hubner, J. Becker, and R. Guerrieri
Subjects: business.industry, Computer science, 020208 electrical & electronic engineering, Design flow, 02 engineering and technology, Integrated circuit layout, Reconfigurable computing, [SPI.TRON]Engineering Sciences [physics]/Electronics, 020202 computer hardware & architecture, ARM architecture, IEEE, Application-specific integrated circuit, Embedded system, Dynamic demand, Scalability, Hardware_INTEGRATEDCIRCUITS, 0202 electrical engineering, electronic engineering, information engineering, [INFO.INFO-ES]Computer Science [cs]/Embedded Systems, System on a chip, business
Abstract: International audience; This paper describes the RTL-to-Layout implementation of the PACT XPP-III Coarse-Grained Reconfigurable Architecture (CGRA). The implementation activity was strictly based on a hierarchical approach in order to exploit performance optimization at all levels, as well as guarantee maximum scalability and provide a portfolio of IP-blocks that could be reused to build different configurations and embodiments of the same CGRA template. The final result can be seamlessly introduced in any SoC design flow as embedded accelerator. It is designed in STMicroelectronics 90nm GP technology, occupies 42.5 mm2, delivers 13 16-bit GOPS (0.8 GOPS/mW, 10 MOPS/mW) and has a measured max frequency of 150 MHZ, requiring a measured 13 mW/MHz dynamic power, 93 mW static. A silicon prototype was also produced embedding XPP-III in a complex system-on-chip including an ARM processor as system controller as well as different ASIC blocks.
Published: 2009

35. A multi-core signal processor for heterogeneous reconfigurable computing

Author: Sean Whitty, A. Deledda, Jürgen Becker, S. Guyetant, Fabio Campi, Rolf Ernst, Davide Rossi, Wolfram Putzke-Roeming, Michael Hübner, S. Chevobbe, S. Pucillo, Claudio Mucci, Matthias Kühnle, D. Rossi, F. Campi, A. Deledda, C. Mucci, S. Pucillo, S. Whitty, R. Ernst, S. Chevobbe, S. Guyetant, M. Kühnle, M. Hübner, J. Becker, and W. Putzke-Roeming
Subjects: Multi-core processor, Digital signal processor, DIGITAL SIGNAL PROCESSORS, MULTICORE SYSTEM ON CHIP, Computer science, Reconfigurable computing, Computation, heterogeneous architecture, Kernel (image processing), Computer architecture, System on a chip, User interface, Field-programmable gate array
Abstract: Reconfigurable computing holds the promise of delivering ASIC-like performance while preserving run-time flexibility of processors. In many application domains, the use of FPGAs is limited by area, power, and timing overheads. Coarse-grained reconfigurable architectures offer higher computation density, but at the price of rather being domain specific. Programmability is also a major issue related to all of the described solutions. This paper describes a heterogeneous multi-core system-on-chip that exploits different flavours of reconfigurable computing, merged together in a high parallel on-chip and off-chip interconnect utilized for both data and configuration. The aim of this work is to deliver a single monolithic engine that capitalizes on the strong points of different reconfigurable fabrics, while providing a friendly programming interface. The user is ultimately able to manage a broad spectrum of different applications, exploiting the most efficient means of computation through utilization of each kernel, while retaining a software-oriented development environment as much as possible.
Published: 2009

36. A reconfigurable heterogeneous multiprocessor System on Chip

Author: BOCCHI, MASSIMO, DE DOMINICIS, MARIO, MUCCI, CLAUDIO, DELEDDA, ANTONIO, CAPPELLI, ANDREA, LODI, ANDREA, CAMPI, FABIO, CICCARELLI, LUCA, TOMA, MARIO, GUERRIERI, ROBERTO, C. De Bartolomeis, M. Innocenti, M. Bocchi, M. De Dominici, C. Mucci, A. Deledda, C. De Bartolomei, A. Cappelli, M. Innocenti, A. Lodi, F. Campi, L. Ciccarelli, M. Toma, and R. Guerrieri
Published: 2006

37. A C-based Programming Enviroment for a heterogeneous reconfigurable system

Author: MUCCI, CLAUDIO, BOCCHI, MASSIMO, CAPPELLI, ANDREA, LODI, ANDREA, TOMA, MARIO, CAMPI, FABIO, GUERRIERI, ROBERTO, P. gagliardi, M. Innocenti, R. Giansante, C. Mucci, M. Bocchi, P. gagliardi, A. Cappelli, M. Innocenti, R. Giansante, A. Lodi, M. Toma, F. Campi, and R. Guerrieri
Published: 2006

38. Baseband analog front-end and digital back-end for reconfigurable multi-standard terminals

Author: A Baschirotto, Mario Toma, Piero Malcovati, Rinaldo Castello, G. Cesura, R. Lodi, Roberto Guerrieri, Fabio Campi, L. Lavagno, A. Baschirotto, R. Castello, F. campi, G. Cesura, M. Toma, R. Guerrieri, A. Lodi, L. Lavagno, P. Malcovati, Baschirotto, A, Castello, R, Campi, F, Cesura, G, Toma, M, Guerrieri, R, Lodi, R, Lavagno, L, and Malcovati, P
Subjects: reconfigurable multi-standard terminal, Engineering, cellular radio, code division multiple acce, QoS, E-GPRS, analogue circuit, law.invention, Bluetooth, Analog front-end, IEEE 802.11, GSM, law, digital back-end, mobile handset, telecommunication standard, UMTS, Electrical and Electronic Engineering, wireless LAN, business.industry, Wireless network, reconfigurable building block, IEEE 802.11g, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, baseband analog front-end, power consumption, voice communication, IEEE 802.11b, digital circuit, Computer Science Applications, IEEE 802.11a, WLAN, Handover, 3G mobile communication, EDGE, WCDMA, mobile terminal, quality of service, Enhanced Data Rates for GSM Evolution, multi-mode cellular handset, business, data communication, UMTS frequency bands, Computer network
Abstract: Multimedia applications are driving wireless network operators to add high-speed data services such as Edge (E-GPRS), WCDMA (UMTS) and WLAN (IEEE 802.11a,b,g) to the existing network. This creates the need for multi-mode cellular handsets that support a wide range of communication standards, each with a different RF freguency, signal bandwidth, modulation scheme, etc. This in turn generates several design challenges for the analog and digital building blocks of the physical layer. In addition to the above-mentioned protocols, mobile devices often include Bluetooth, GPS, FM-radio and TV services that can work concurrently with data and voice communication. Multi-mode, multi-band, and multi-standard mobile terminals must satisfy all these different reguirements. Sharing and/or switching transceiver building blocks in these handsets is mandatory in order to extend battery life and/or to reduce cost. Only adaptive circuits that are able to reconfigure themselves within the handover time can meet the design reguirements of a single receiver or transmitter covering all the different standards while ensuring seamless inter-interoperability. This paper presents analog and digital base-band circuits that are able to support GSM (with Edge), WCDMA (UMTS), WLAN and Bluetooth using reconfigurable building blocks. The blocks can trade off power consumption for performance on the fly, depending on the standard to be supported and the reguired QoS (Quality of Service) level. © 2006 IEEE.
Published: 2006

39. Design and implementation of a reconfigurable heterogeneous multiprocessor SoC

Author: Massimo Bocchi, Claudio Mucci, Fabio Campi, M. De Dominicis, Mario Toma, A. Deledda, Andrea Lodi, Roberto Guerrieri, M. Bocchi, M. De Dominici, C. Mucci, A. Deledda, F. Campi, A. Lodi, M. Toma, and R. Guerrieri
Subjects: Signal processing, Reduced instruction set computing, Computer architecture, Coupling (computer programming), Computer science, Clock rate, Multiprocessing, System on a chip, Reconfigurable computing, Energy (signal processing)
Abstract: This paper introduces a novel heterogeneous shared memory multiprocessor architecture based on a reconfigurable processor and a standard RISC processor. The work aims at increasing further the computational density of a reconfigurable device by the integration of the reconfigurable hardware into a heterogeneous multi-core architecture. Though a RISC processor has a lower inner computational density than a reconfigurable processor, this work demonstrates that coupling a reconfigurable core to a RISC core leads to a computational density increase by a factor of up to 1.7times on signal processing applications. Moreover, this approach also achieves up to 37% energy savings on the same applications. The multi-core SoC architecture was implemented in 0.13mum technology, achieving a 166MHz clock frequency with an average 340mW power consumption
Published: 2006

40. Vascular lesions in pathological shoulder conditions

Author: GARGIULO, MAURO, FAGGIOLI, GIANLUCA, STELLA, ANDREA, M. Bessone, F. Maioli, G. PORCELLINI F. CAMPI P. PALADINI, M. Gargiulo, M. Bessone, F. Maioli, G.L. Faggioli, and A. Stella
Published: 2005

41. A FPGA Implementation of An Open-Source Floating-Point Computation System

Author: Fabio Garzia, Jari Nurmi, C. Mucci, Davide Rossi, Claudio Brunelli, Fabio Campi, C. Brunelli, F. Garzia, J. Nurmi C. Mucci, F. Campi, and D. Rossi
Subjects: Floating point, Reduced instruction set computing, Computer science, business.industry, floaing point unit, open source, Logic synthesis, Application-specific integrated circuit, Embedded system, system-on-chip, VHDL, System on a chip, Hardware_ARITHMETICANDLOGICSTRUCTURES, Field-programmable gate array, business, computer, Massively parallel, computer.programming_language
Abstract: FPGAs are commonly used to provide a fast way to system prototyping. Thanks to their ever increasing amount of logic elements, their massively parallel architectures, and their dedicated computational elements they offer the possibility to implement entire complex systems like SoCs, reaching computational performances comparable to ASIC logic or embedded processors in a broad range of applications. This paper presents the implementation on a FPGA board of an open source, technology independent, VHDL model of a floating-point computation environment for SoCs, composed of a RISC microprocessor system closely coupled to a floating-point unit. The FPU features a full hardware handling of normalization and denormalization hazards. A benchmark suite of DSP algorithms written in C language has been run on the proposed platform.
Published: 2005

42. XiSystem: a XiRisc-based SoC with Reconfigurable IO module

Author: Mario Toma, C. De Bartolomeis, Roberto Giansante, Massimo Bocchi, Claudio Mucci, M. Innocenti, Roberto Guerrieri, Andrea Cappelli, Fabio Campi, Luca Ciccarelli, A. Deledda, Andrea Lodi, IEEE INTERNATIONAL SOLID-STATE CIRCUITS CONFERENCE (ISSCC 2005), A. Cappelli, A. Lodi, M. Bocchi, C. Mucci, M. Innocenti, C. De Bartolomei, L. Ciccarelli, R. Giansante, A. Deledda, F. Campi, M. Toma, and R. Guerrieri
Subjects: Digital signal processor, Engineering, Reduced instruction set computing, business.industry, Energy consumption, Integrated circuit, law.invention, CMOS, law, Embedded system, System on a chip, Electrical and Electronic Engineering, business, Field-programmable gate array, Digital signal processing
Abstract: In the nanometer era, the increase in nonrecurring engineering costs is a challenge for SoCs that can be faced through a standardization process. Hardware specialization of a standard platform to a given application can be achieved by exploiting reconfigurable technology. This paper presents a XiSystem SoC, which integrates two different field-programmable devices to provide application-specific computing blocks and IOs. A XiRisc reconfigurable processor is exploited to achieve more than one order of magnitude speed-up and energy consumption reduction vis-a/spl grave/-vis a DSP-like processor, while an eFPGA is integrated in the system in order to make it flexible enough to support various IO ports and protocols. The reconfigurable IO device is also utilized for pre/post data processing and implementation of some standard computational blocks.
Published: 2005

43. A XiRisc-based SoC for Embedded DSP for Embedded DSP Applications

Author: BOCCHI, MASSIMO, MUCCI, CLAUDIO, CAMPI, FABIO, LODI, ANDREA, TOMA, MARIO, CANEGALLO, ROBERTO, GUERRIERI, ROBERTO, C. De Bartolomeis, IEEE CUSTOM INTEGRATED CIRCUITS CONFERENCE (CICC), M. Bocchi, C. De Bartolomei, C. Mucci, F. Campi, A. Lodi, M. Toma, R. Canegallo, and R. Guerrieri
Published: 2004

44. Probe set selection for targeted spatial transcriptomics.

Author: Kuemmerle LB, Luecken MD, Firsova AB, Barros de Andrade E Sousa L, Straßer L, Mekki II, Campi F, Heumos L, Shulman M, Beliaeva V, Hediyeh-Zadeh S, Schaar AC, Mahbubani KT, Sountoulidis A, Balassa T, Kovacs F, Horvath P, Piraud M, Ertürk A, Samakovlis C, and Theis FJ
Abstract: Targeted spatial transcriptomic methods capture the topology of cell types and states in tissues at single-cell and subcellular resolution by measuring the expression of a predefined set of genes. The selection of an optimal set of probed genes is crucial for capturing the spatial signals present in a tissue. This requires selecting the most informative, yet minimal, set of genes to profile (gene set selection) for which it is possible to build probes (probe design). However, current selections often rely on marker genes, precluding them from detecting continuous spatial signals or new states. We present Spapros, an end-to-end probe set selection pipeline that optimizes both gene set specificity for cell type identification and within-cell type expression variation to resolve spatially distinct populations while considering prior knowledge as well as probe design and expression constraints. We evaluated Spapros and show that it outperforms other selection approaches in both cell type recovery and recovering expression variation beyond cell types. Furthermore, we used Spapros to design a single-cell resolution in situ hybridization on tissues (SCRINSHOT) experiment of adult lung tissue to demonstrate how probes selected with Spapros identify cell types of interest and detect spatial variation even within cell types., Competing Interests: Competing interests F.J.T. consults for Immunai Inc., CytoReason Ltd, Cellarity and BioTuring Inc., and has an ownership interest in Dermagnostix GmbH and Cellarity. M.D.L. contracted for the Chan Zuckerberg Initiative and received speaker fees from Pfizer and Janssen Pharmaceuticals. P.H., F.K. and T.B. acknowledge support from TKP2021-EGA09, Horizon-BIALYMPH, -SYMMETRY, -SWEEPICS, -Fair-CHARM and OTKA-SNN 139455., (© 2024. The Author(s).)
Published: 2024
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45. Mid-infrared optical parametric chirped-pulse amplifier at 50 W and 38 fs pumped by a high-power Yb-InnoSlab platform.

Author: Buss JH, Starosielec S, Schulz M, Riedel R, Campi F, Lehmann CS, Witte S, and Kraus PM
Abstract: High-power Yb:InnoSlab lasers are proliferating into multiple modern application areas of laser physics ranging from plasma physics and nanolithography to driving optical parametric amplifiers for high-harmonic generation and attosecond science. Here, we present, the layout, design and first results of an optical parametric chirped-pulse amplifier system pumped by a kW-level average power Yb-InnoSlab laser. We describe the layout and concepts of the pump lasers, with particular attention to the specific design principles required for our application. In the current configuration, the pump laser delivers up to 933 W, 18.7 mJ, 1.2 ps pulses at 50 kHz repetition rate. In a first attempt this has generated above 70 W average power at 2 μm via parametric amplification. Chirped-mirror compression resulted in mJ-level pulses at 50 W and 38-fs pulse duration (5.7 cycles at 2 μm).
Published: 2024
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46. Coagulation profiles and percentiles in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia: A step toward more accurate transfusion thresholds.

Author: De Rose DU, Maddaloni C, Ronci S, Bersani I, Martini L, Caoci S, Savarese I, Di Pede A, Campi F, Di Felice G, Berti P, Porzio O, Luciani M, and Dotta A
Subjects: Humans, Infant, Newborn, Retrospective Studies, Male, Female, Blood Coagulation, Prognosis, Follow-Up Studies, Blood Coagulation Tests methods, Hypoxia-Ischemia, Brain therapy, Hypoxia-Ischemia, Brain blood, Hypothermia, Induced methods, Blood Transfusion methods
Abstract: Background: In the literature, there are no studies about the transfusion threshold for neonates with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). In order to facilitate accurate interpretation of coagulation results in these neonates, we aimed to generate specific reference intervals in this specific population., Methods: This retrospective study included all HIE neonates admitted from 2014 to 2022 to undergo TH. All infants during TH underwent blood exams, including the coagulation profile. Our primary outcome was to assess the estimates of the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles for each parameter on admission (before transfusion). By the receiver operating characteristic (ROC) analysis, the area under the ROC curve (AUC) and the best cut-off point were used to evaluate the ability of the prothrombin time expressed as international normalized ratio (PT-INR) to predict the risk of any bleeding., Results: A total of 143 infants were included in this study. On admission, the median fibrinogen value was 205 mg/dL, prothrombin time 18.6 seconds, PT-INR 1.50, activated partial thromboplastin time 38.3 seconds, thrombin time 18.6 seconds, antithrombin 57.0%. The optimal cut-off of PT-INR in predicting the risk of any bleeding was greater than 1.84 (AUC .623, p = .024)., Conclusion: For the first time, we proposed the percentiles of coagulation parameters in our cohort of neonates with HIE. Furthermore, we found that a PT-INR greater than 1.84 can significantly predict the risk of any bleeding. Further studies are needed to determine if a restrictive versus a liberal transfusion approach can be equally safer for these high-risk infants., (© 2024 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.)
Published: 2024
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47. Enhancing the efficiency of high-order harmonics with two-color non-collinear wave mixing in silica.

Author: Roscam Abbing SDC, Kuzkova N, van der Linden R, Campi F, de Keijzer B, Morice C, Zhang ZY, van der Geest MLS, and Kraus PM
Abstract: The emission of high-order harmonics from solids under intense laser-pulse irradiation is revolutionizing our understanding of strong-field solid-light interactions, while simultaneously opening avenues towards novel, all-solid, coherent, short-wavelength table-top sources with tailored emission profiles and nanoscale light-field control. To date, broadband spectra in solids have been generated well into the extreme-ultraviolet (XUV), but the comparatively low conversion efficiency in the XUV range achieved under optimal conditions still lags behind gas-based high-harmonic generation (HHG) sources. Here, we demonstrate that two-color high-order harmonic wave mixing in a fused silica solid is more efficient than solid HHG driven by a single color. This finding has significant implications for compact XUV sources where gas-based HHG is not feasible, as solid XUV wave mixing surpasses solid-HHG in performance. Moreover, our results enable utilizing solid high-order harmonic wave mixing as a probe of structure or material dynamics of the generating solid, which will enable reducing measurement times compared to the less efficient regular solid HHG. The emission intensity scaling that follows perturbative optical wave mixing, combined with the angular separation of the emitted frequencies, makes our approach a decisive step for all-solid coherent XUV sources and for studying light-engineered materials., (© 2024. The Author(s).)
Published: 2024
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48. Lutetium-177 Therapy in Italy: Environmental Impact Assessment in Anticipation of Its Widespread Use in Prostate Cancer Treatment.

Author: Brusa A, Campi F, Cavatorta C, Porta AA, and Viganò S
Abstract: Abstract: This article addresses the evolving state of lutetium-177 radiopharmaceutical therapies in Italy, focusing on the importance of the definition of patient management practices regarding the approved treatments based on [177Lu]Lu-DOTATATE for neuroendocrine tumors and [177Lu]Lu-PSMA-617 for metastatic castration-resistant prostate cancer. Italian medical facilities are facing new challenges with the increase in the demand for such therapies while transitioning from restrictive hospitalization requirements to more flexible outpatient options. Therefore, four management strategies are described here, varying from immediate discharge after the administration to 24-h hospitalization, and their environmental and radiation safety implications are evaluated through simple models aimed at assessing the effective doses on the local population and wastewater purification plant workers. Results show that, while higher effective doses may be caused by an immediate discharge-based modality, they remain within acceptable limits, particularly when dealing with a smaller number of patients. Prolonged hospitalizations guarantee superior radiation safety levels but might not be sustainable with the expected increase in patient volumes in the future., (Copyright © 2024 Health Physics Society.)
Published: 2024
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49. MRI scan with the "feed and wrap" technique and with an optimized anesthesia protocol: a retrospective analysis of a single-center experience.

Author: Moltoni G, Lucignani G, Sgrò S, Guarnera A, Rossi Espagnet MC, Dellepiane F, Carducci C, Liberi S, Iacoella E, Evangelisti G, Contini A, Campi F, Savarese I, Gandolfo C, and Longo D
Abstract: Introduction: MRI examinations in the pediatric population require acquiring motionless images in the safest possible manner. At our institute, we have developed a protocol called "Good Practice" aimed at avoiding anesthesia in newborns and infants through the use of the "feed and wrap" technique, as well as preventing hospitalization for older children requiring anesthesia with an optimized sedation protocol. We evaluated this protocol in terms of patient safety, imaging quality, and parental satisfaction., Materials and Methods: Patient data were collected retrospectively. In the feed and wrap group, image quality and the necessity of repeating the examination were evaluated. In the optimized anesthesiologic protocol group, various parameters were analyzed to assess the safety of the protocol. Parental satisfaction was determined through a questionnaire., Results: A total of 132 patients were included, with 82 undergoing the feed and wrap technique and 50 receiving the optimized anesthesiologic protocol. In the feed and wrap group, images were classified as follows: 4.87% poor, 18.29% sufficient, 37.80% good, and 39.92% excellent. In only 2 cases a new MRI examination was required. In the optimized anesthesiologic protocol group, no adverse effects were observed, and no post-anesthesia hospitalizations were needed. 100% of parents of babies examined with the feed and wrap technique rated it as excellent. Furthermore, 85.6% of parents considered the optimized anesthesiologic protocol excellent, and 13.6% rated it as good., Conclusion: At our institute, the feed and wrap technique proved to be effective in obtaining high-quality images. Anesthesia using propofol showed no adverse effects and proved to be successful in avoiding hospitalization. Parents expressed relief at the avoidance of anesthesia and hospitalization for their children., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Moltoni, Lucignani, Sgrò, Guarnera, Rossi Espagnet, Dellepiane, Carducci, Liberi, Iacoella, Evangelisti, Contini, Campi, Savarese, Gandolfo and Longo.)
Published: 2024
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50. Role of Brain Elastography in the Neonatal Setting: State of the Art of Ultrasonographic Techniques and Future Perspectives.

Author: Piersigilli F, Campi F, Savarese I, Iacona G, Auriti C, Dotta A, Braguglia A, Garcovich M, and Bersani I
Abstract: Magnetic resonance imaging is currently used in the neonatal setting for assessing features of the neonatal brain. However, its utilization is constrained by logistic, technical, or clinical challenges. Brain elastography is a new research technique which enhances the diagnostic capability of traditional imaging, and can be paired with both ultrasonography and magnetic resonance imaging. In particular, brain elastography adds objective and quantitative information to traditional imaging by detecting differences in tissue elasticity/stiffness, which may represent a surrogate marker of the physiologic and pathologic features of the neonatal brain. To date, very limited experience exists about the use of brain elastography specifically in the neonatal setting. The aim of the present review was to describe the most recent information about the feasibility and diagnostic accuracy of brain ultrasound elastography (USE) in neonates, and to provide information about the possible future applications and perspectives of brain elastography.
Published: 2024
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